@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NPT2C_HUMAN: (2015-12-08 )
MPSSLPGSQVPHPTLDAVDLVEKTLRNEGTSSSAPVLEEGDTDPWTLPQLKDTSQPWKELRVAGRLRRVAGSVLKACGLLGSLYFFICSLDVLSSAFQLLGSKVAGDIFKDNVVLSNPVAGLVIGVLVTALVQSSSTSSSIVVSMVAAKLLTVRVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATALLERLSELALGAASLTPRAQAPDILKVLTKPLTHLIVQLDSDMIMSSATGNATNSSLIKHWCGTTGQPTQENSSCGAFGPCTEKNSTAPADRLPCRHLFAGTELTDLAVGCILLAGSLLVLCGCLVLIVKLLNSVLRGRVAQVVRTVINADFPFPLGWLGGYLAVLAGAGLTFALQSSSVFTAAVVPLMGVGVISLDRAYPLLLGSNIGTTTTALLAALASPADRMLSALQVALIHFFFNLAGILLWYLVPALRLPIPLARHFGVVTARYRWVAGVYLLLGFLLLPLAAFGLSLAGGMELAAVGGPLVGLVLLVILVTVLQRRRPAWLPVRLRSWAWLPVWLHSLEPWDRLVTRCCPCNVCSPPKATTKEAYCYENPEILASQQL
Atome Classification :
(19 SA)
----------------------------------------.........10.---.......20......--..30.------...----------------....40....-------------....50........--------------60.---.......70------........80---------.......--.-----90........100....------------.-----..110.-......120..------------.....130.-----......140------.....--------....150...-.------..-------.160.......170......--------.180.-......190.......200-......-----.210.......220.......230----.........240.-..----....250.......260..-----------------....----.270----------------------........280.......290.......300.......310.--......320-....---....330----........340...--....350--.-.......360.......370..-------------------------------------.-....380....--.------------------------..------------390-....-------.-------..400.......------------------410....--...420.--......---430.-------.......--440......-.450.------...---...460--------........--.470---......---------------.480.......490------------------........---.500-------------------..---......510-.------......520......-.530.......540....------------...550-------------.......560-..-.....-570.......580-----------------------.....--..-..590........--------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------MPSSLPGSQVPH---PTL
D
A
V
D
L
V
E
K
T
L
RN--EGTSS------SAP----------------VLEEGDTDPW-------------TLPQLKDTSQ
P
W
K
E
--------------
L
R
V
---
A
G
R
L
R
R
V
A
G
------
S
V
L
K
A
C
G
L
L
G
---------
S
L
Y
F
F
I
C
--
S
-----
L
D
V
L
S
S
A
F
Q
L
L
G
S
K
V
A
G
------------
D
-----IFKDN
V
-
V
LSN
P
V
A
G
L
V
I
------------
G
V
L
V
T
A
L
V
Q-----SSSTS
S
S
--------
I
V
V
S
M
--------
V
A
A
K
L
L
T
V
R
V
-S------
V
P
-------
I
I
M
GVNVG
T
S
I
T
S
T
L
V
S
M
A
Q--------SG
D
R
D
-
E
F
Q
R
A
FSG
S
A
V
H
G
I
F
N
W
L
T
-
V
L
V
LLP-----L
E
S
A
T
A
L
L
E
R
L
S
E
L
A
LGAASLT------PRAQA
P
D
I
L
K
V
L
T
-
K
P
----
L
T
H
L
I
V
QLDSD
M
I
MSSATG-----------------NAT
N
----
S
S
L
-----------------------
I
K
H
W
CGTTGQPTQENSSCGAFGPCTEKNSTAPADRL
P
C
R
H
LF--AGT
E
L
T
D
L
--
A
V
G
C
---
I
L
L
A
G
S
-----
L
L
V
L
C
G
C
L
V
L
I
V
K
L
--
L
N
S
V
L
R
---
G
-
R
V
A
Q
V
V
R
T
V
INADFPF
P
L
G
W
L
G
-------------------------------------
G
-
Y
L
A
V
L
AGA
G
L
T
--
F
------------------------
A
L------------QSS-S
V
F
T
-------
A
-------
A
V
V
P
L
M
G
V
G
V
I
S------------------LDRA
Y
P
L
--
L
LGSNI
G
--
T
T
T
T
A
L
---
L
A
-
A
-------LAS
P
A
D
R
--
M
L
S
A
L
Q
V
A
L
-
I
H
F
F
F
------
N
L
A
---
G
I
L
L
----------
W
Y
L
V
P
A
L
R--LPI
P
---
L
A
R
HFG---------------
V
V
T
A
R
Y
R
W
V
A
G
V
--------------------
Y
L
L
L
G
F
L
L
---
L
P
L
--------------------
A
A
---
F
G
L
S
LAG
G
M
-
E
------
L
AAVG
G
P
L
V
G
L
V
L
L
V
-
I
L
V
T
V
L
QRRRPA
W
L
P
V
R
L------------RS
W
A
W
L
-------------
P
V
W
L
H
SLE
P
W
-
D
R
-
L
V
T
RC-CPCNVCSPPKA-------------------------TTK
E
A
--YC-YEN-
P
E
I
LASQQL--------------------------------------------------------------------------------------------
14
Fugue
84.48
20%
-113
* C6 *
5AGA
1
DPOLQ_HUMAN
A:
[3-827]
-------------------------------DKLLLANWG
L
P
K
A
V
L
E
K
Y
H
S
F
---
G
V
K
K
M
F
E
W
Q
A
E
C
L
L
L
--
G
Q
V
L
E
G
K
N
L
V
Y
S
A
P
T
SAG
K
T
L
V
A
E
L
L
I
L
K
R
V
L
E
M
R
K
K
A
L
F
-------------
I
L
P
F
V
S
V
A
K
E
--
K
K
--------------
Y
Y
L
---
Q
S
L
F
Q
E
V
G
---------
I
K
V
D
G
Y
M
G
STSPSRHFS
S
L
D
I
A
V
C
--
T
-----
I
E
R
A
N
G
L
I
N
R
L
I
E
E
N
K
M
------------
D
LLG
M
V
V
V
D
E
L
H
-
M
L
G
D
S
H
R
G
Y
L
L
------------
E
L
L
L
T
K
I
C
Y
-----
I
T
R
K
S
A
S
CQADSNA
V
Q
I
V
G
M
S
A
TLPN
L
E
L
V
A
S
W
L
N
A
E
L
-
Y
H
T
DFRP
V
P
-------
L
L
E
S
V
K
V
G
N
S
I
Y
D
S
S
M
K
L
V
R
EFEPM
L
Q
V
K
G
D
E
D
-
H
V
V
S
L
C
Y
E
T
I
C
D
N
----
H
S
-
V
L
L
F
C
P
S
K
K
W
C
E
K
L
A
D
I
I
A
R
E
F
Y
N
L
H
H
Q
A
S
E
C
P
------
P
V
I
L
E
Q
K
E
L
L
E
V
M
-
D
Q
----
L
R
R
L
P
S
G
L
D
S
V
L
Q
K
T
V
P
W
G
V
A
F
H
H
AGLT
F
E
E
R
D
I
I
E
G
A
F
R
----
Q
G
L
-----------------------
I
R
V
L
A
A
T
S
T
L
S
S
G
V
N
L
P
A
R
R
V
I
I
R
T
P
I
F
G
G
R
P
L
D
I
L
T
Y
K
Q
M
V
G
R
A
G
R
K
G
V
D
T
--
V
G
E
S
---
I
L
I
C
K
N
-----
S
E
K
S
K
G
I
A
L
L
Q
G
S
L
K
P
V
R
S
C
L
Q
-----
R
G
E
E
V
T
G
S
M
I
R
A
I
L
E
I
I
V
G
G
V
A
-------------------------------------
S
T
S
Q
D
M
H
T
Y
A
A
C
T
--
F
------------------------
L
A
------------
A
S
M
-
G
A
I
E
-------
A
-------
C
V
M
W
L
L
E
N
E
F
I
Q
------------------
S
T
E
E
G
K
V
--
Y
H
P
T
H
L
G
--
S
A
T
L
S
S
SLS
P
A
-
D
-------
T
L
D
I
F
A
D
--
L
Q
R
A
M
K
G
F
V
-
L
E
N
D
L
------
H
I
L
---
Y
L
V
T
PMFEDWTTID
W
Y
R
F
F
C
L
W
E
K
L
P
T
S
---
M
K
R
V
A
E
---------------
L
V
G
V
E
E
G
F
L
A
R
C
V
K
GKVVARTERQHR
Q
M
A
I
H
K
R
F
F
T
S
L
V
L
---
L
D
L
I
S
EVP
L
R
E
I
N
Q
K
Y
GCN
R
G
Q
I
Q
S
---
L
Q
Q
S
A
A
V
Y
A
-
G
------
M
I
T
V
F
S
N
R
L
G
W
H
N
M
E
-
L
L
L
S
Q
F
Q
K
R
L
T
F
G
I
Q
R
E
L
CDLVRVSLLN
A
Q
R
A
R
V
L
Y
-------------
A
S
G
F
H
T
V
A
D
L
-
A
R
-
A
N
I
V
E
-
V
E
V
I
L
K
N
A
V
P
F
KSARKEAVEERRNMRT
I
W
V
T
GRKGL
T
E
R
E
A
A
A
L
I
-
V
E
E
-
A
R
M
I
L
Q
Q
D
L
--------------------------------------------------------------------------------------------
16
Fugue
69.46
14%
-102
* C5 *
4UFC
1
?
A:
[21-807]
DL
K
L
W
Y
SQPAQNWSE
A
L
P
I
G
NSR
L
G
A
M
V
YGGIE
R
E
E
L
Q
L
N
E
E
T
F
W
A
G
S
P
Y
N
N
NNP
N
A
V
H
V
L
P
V
V
R
K
L
I
F
E
--
G
R
N
K
E
------
A
Q
R
----------------
L
I
D
A
N
F
L
T
Q
Q
H
G
M
S
Y
L
T
L
G
S
L
Y
L
E
F
P
E
H
Q
N
G
S
G
F
Y
R
D
--------------
L
N
L
ENA
T
T
T
T
R
Y
Q
V
D
------
D
V
T
Y
T
R
T
T
F
A
---------
S
F
T
D
N
V
I
--
I
-----
M
H
I
K
A
S
K
A
N
A
L
N
F
T
I
A
--------------------
Y
N
C
P
L
-
V
H
K
V
N
V
Q
N
D
Q
L
------------
T
V
T
C
Q
G
K
E
Q
-----
E
G
L
K
A
A
L
--------
R
A
E
C
Q
--------
I
Q
V
K
T
N
G
T
L
R
-
P
------
A
G
-------
N
T
L
Q
I
N
E
G
T
E
A
T
L
Y
I
S
A
A
T
N
--------
Y
V
N
Y
Q
-
D
V
----
S
A
D
E
S
H
R
T
S
E
Y
L
K
-
R
A
M
Q
I
P
-----
Y
E
K
A
L
K
N
H
I
A
Y
Y
K
K
Q
F
D
R
V
R
L
T
L
P
AGKA
S
Q
L
E
T
P
K
R
I
E
N
F
G
-
N
G
ED
M
A
M
A
A
L
L
F
H
Y
G
R
Y
L
L
I
S
S
S
Q
P
-----------------
G
G
Q
P
----
A
N
L
QGIWNNSTHAPWDSKYTINI
N
T
E
M
N
Y
W
P
A
E
V
T
N
L
S
E
T
H
S
P
L
F
S
M
L
K
D
L
S
V
T
G
A
E
T
A
R
T
M
Y
D
C
R
G
W
--
V
A
H
H
N
T
D
L
WR
I
C
G
V
---
V
D
F
A
A
A
-----
G
M
W
P
S
G
G
A
W
L
A
Q
H
I
--
W
Q
H
Y
L
F
T
GN
K
-
E
F
L
K
E
Y
Y
P
I
L
K
G
T
A
Q
F
Y
M
D
F
L
V
EHPVYK
W
L
V
V
S
PSVSPEHGPITAGC
T
M
D
N
Q
I
A
F
D
A
L
H
N
-
T
L
L
A
S
Y
I
A
G
E
A
--
P
------------------------
S
F
------------
Q
D
S
-
L
K
Q
T
-------
L
-------
E
K
L
P
P
M
Q
I
G
K
H
N
QLQEWLEDIDNPKDEHRH
I
S
H
L
Y
G
L
--
Y
P
S
N
Q
I
S
PY
S
N
P
E
L
F
---
Q
A
-
A
-------
R
N
T
L
L
Q
R
GD
K
A
T
G
W
S
I
G
W
K
V
N
F
W
A
------
R
M
L
D--
G
N
H
A
----------
F
Q
I
I
K
N
M
I
--
Q
L
L
P
NDH
L
A
K
E
Y
P
NGRTYPNMLDAHPPF
Q
I
D
G
N
F
G
Y
T
A
G
V
--------------------
A
E
M
L
L
Q
S
H
---
D
G
A
--------------------
V
H
---
L
L
P
A
L
P
D
A
W
-
E
E
G
S
V
K
G
L
V
A
R
G
N
F
T
V
D
M
D
W
K
N
-
N
V
L
N
K
A
I
I
R
S
N
I
G
S
T
L
R
I
------------
R
S
Y
V
P
L
K
GKG
L
K
Q
V
N
GKEC
S
N
R
L
F
A
T
T
P
I
-
K
Q
P
L
V
A
K
G
-
V
S
A
Q
S
P
K
L
Q
K
V
-------------------------
Y
E
Y
D
I
--
E
T
-
K
A
G
-
K
T
Y
I
V
N
T
I
---------------------------------------------------------------------------------------------
22
Fugue
62.41
17%
-82
* C4 *
1NTH
1
MTMB1_METBA
A:
[2-458]
-------------------------------------------------
T
F
R
---
K
S
F
D
C
Y
D
F
Y
D
R
A
K
V
G
----------------------------------
E
K
C
T
Q
D
D
W
-------------
D
L
M
K
I
P
M
K
A
M
E
L
K
Q
K
Y
GLDFKGEFIPTD
K
D
M
---
M
E
K
L
F
K
A
G
F
------
E
M
L
L
E
C
G
I
Y
C
---------
T
D
T
H
R
I
V
K
Y
T
-----
E
D
E
I
W
D
A
I
N
N
V
Q
K
E
F
V
L
------------
G
-----
T
G
R
D
A
V
-
N
V
R
K
R
S
----
V
------------
G
D
K
A
K
P
I
V
Q
-----
G
G
P
T
G
S
P
--------
I
S
------------
E
D
V
F
M
P
V
H
M
-
S
------
Y
A
-------
L
E
K
E
V
D
T
I
V
N
G
V
M
T
S
V
R
G
K
S
--------
P
I
P
K
S
-
P
Y
E
V
L
A
A
K
T
E
T
R
L
I
K
N
A
C
A
-
M
-
A
G
R
P
-----
G
M
G
V
K
G
P
E
T
S
L
S
A
Q
G
N
I
S
A
D
C
T
------
G
G
M
T
C
T
D
--------------
S
H
E
V
S
Q
L
N
E
L
K
I
-----------------------
D
L
D
A
----
I
S
V
-----------------------
I
A
H
Y
K
G
N
S
D
I
I
M
D
E
Q
--------------------
M
P
I
F
G
G
Y
--
A
G
G
-
I
E
E
T
--
T
I
V
D
---
V
A
T
H
I
N
-----
A
V
L
M
S
S
A
S
----------------------------
W
H
L
D
G
P
V
H
I
R
W
-----------------------------------------------------------------------------------------------
G
-
S
T
N
T
-------
R
-------
E
T
L
M
I
A
G
W
A
C
A
T
------------------
I
S
E
F
T
D
I
--
L
S
G
N
Q
Y
Y
--
P
C
-------------------
A
G
P
C
T
E
--
M
C
-
L
L
E
A
S
A
-
Q
S
I
T
D
------
T
A
S
---
G
-------------------------------------------------------
R
-
E
I
L
S
G
V
--------------------
A
S
A
K
G
V
V
T
---
D
K
T
--------------------
T
G
---
M
E
A
R
M
M
G
E
V
-
A
------
R
A
T
A
G
V
E
I
S
E
V
N
V
I
L
-
D
K
L
V
S
L
Y
E
K
N
Y
A
S
A
P
A
G
-------------
K
T
F
Q
E
C
--------------
Y
D
V
K
T
V
T
P
-----------------------------------------------
T
E
E
Y
M
--
Q
V
-
Y
D
G
A
R
K
K
L
E
D
L
G
L
VF------------------------------------------------------------------------------------------
17
Fugue
61.11
15%
-94
- C6 -
4B28
-
DDDP_ROSDO
A:
[32-468]
----------------------------------------------------------
R
K
I
D
P
S
R
G
A
T
L
G
--
D
G
S
P
N
------
D
M
N
----------------
R
V
E
I
G
P
T
Q
L
A
-------------
F
A
E
W
H
T
A
R
L
D
L
P
D
L
--------------
A
A
M
---
R
R
F
R
H
R
R
L
T
------
D
H
V
V
A
R
G
Y
A
G
---------
L
L
M
F
D
P
L
--
N
-----
I
R
Y
A
T
D
S
T
N
M
----------------------------
Q
L
W
-
N
T
H
N
P
F
R
A
T
L
L
------------
C
A
D
G
Y
M
V
M
W
-----
D
Y
K
N
S
P
F
--------
L
S
E
F
N
-----------
P
L
V
R
E
Q
R
-
A
------
G
A
-------
D
L
F
Y
F
D
R
G
D
K
V
D
V
A
A
D
V
F
A
N
----------
E
V
R
-
I
L
L
R
D
H
A
P
G
L
R
R
L
A
V
D
K
V
M
-
L
H
G
L
R
A
-----
L
Q
A
-
Q
G
F
E
I
M
D
G
E
E
V
T
E
K
A
R
S
V
------
K
G
P
D
E
I
R
A
M
R
C
A
S
-
H
A
----
C
E
V
A
V
R
K
M
E
D
F
A
R
S
K
V
G
D
G
-----------------
V
T
C
--------------------------------------------
E
N
D
---
I
W
A
I
L
H
S
E
N
V
R
R
G
G
E
W
I
E
T
R
L
L
A
--
S
G
P
R
S
N
P
W
--
F
Q
E
C
GPR
V
C
Q
R
N
E
-----
I
I
S
F
D
T
D
L
V
------------------------------------
G
A
Y
G
----------------------------------------------------------------------------------------------------------------------------
I
C
------------------
T
D
I
S
R
S
W
--
W
I
G
D
Q
--------------------------
K
P
R
A
D
--
M
I
Y
A
M
Q
H
G
V
-
E
H
I
R
T
------
N
M
E
------------------
M
L
K
P
G
V
M
--
I
P
-
E
---
L
S
A
N
T
H
---------------
V
L
D
A
K
F
Q
K
Q
K
Y
G
--------------------
C
L
M
H
G
V
G
L
CDE
W
P
L
--------------------
V
A
---
Y
P
D
H
A
V
A
G
-----------
A
Y
D
Y
P
L
E
P
G
M
T
L
C
-
V
E
A
L
I
S
E
E
G
G
D
F
--
S
I
K
L
------------
E
D
Q
V
L
I
-------------
T
------
E
D
G
-
Y
E
-
N
L
T
K
------------------------------------------------
Y
P
F
-
D
P
A
L
M
G
-----------------------------------------------------------------------------------------------
23
Fugue
57.25
19%
-91
- C4 -
4KQA
2
FA20C_CAEEL
A:
[3-428]
---------------------------------------------
P
H
Q
P
I
P
----
P
S
L
G
E
K
D
L
--------------------
S
D
P
----------------
F
N
F
L
F
S
S
N
K
I
-------------
T
L
R
K
L
Y
D
L
T
K
N
V
D
---------------------
F
D
Q
L
R
Q
------------
N
E
C
K
K
N
I
---------
T
L
S
K
F
W
E
--
P
-----
E
D
---
D
N
W
E
R
F
Y
S
N
I
G
S
C-----------
S
-----
V
Y
S
D
D
Q
M
I
-----------------------------------------
D
N
--------
L
L
H
D
L
--------
N
T
S
P
I
K
H
V
H
I
M
D
------
G
T
-------
Q
V
-------
K
F
V
F
T
F
K
N
D
K
Q
--------
A
V
F
K
P
M
R
F
G
R
D
Y
E
S
D
P
N
H
F
Y
F
S
D
F
E
-
R
---
H
H
-----
A
E
I
A
T
F
H
L
D
R
V
---------
L
G
------
F
R
R
A
I
P
T
V
G
R
V
L
N
M
T
------
T
E
L
F
E
K
A
E
K
K
L
K
K
T
F
F
F
S
-----------------
P
A
---------------------------------
K
N
F
C
F
V
--------
S
R
C
D
Y
Y
--
C
D
T
T
H
A
----------------------------------------------
I
C
G
--------------
L
P
---
D
M
K
E
G
S
V
Q
V
F
L
P
D
E
S
A
V
P
R
K
H
N
R
S
-------------------------------------
P
-
Y
R
R
T
Y
S
K
K
N
Q
V
--
A
------------------------
E
W
------------
Q
S
S
M
N
Y
C
T
-------
D
-------
K
V
---------
K
------------------
T
K
R
Q
Y
A
H
-----------------------------------
G
R
R
--
L
L
D
L
V
D
I
H
I
-
L
D
Y
L
I
GNQDRH
H
F
E
---
S
F
N
V
----------
F
N
D
L
P
S
Y
A
--
I
H
L
D
---
H
G
R
A
F
G
---------------
R
S
D
F
D
D
D
D
I
------------------------------
I
---
L
P
L
--------------------
R
Q
CCI
L
R
P
S
T
F
Q
T
L
M
N
------
F
Y
S
T
P
K
S
L
T
K
A
L
H
E
S
-
L
------
S
K
D
P
A
H
------------------------------------
P
I
L
A
Y
K
H
Y
P
A
M
E
R
-
R
L
A
K
I
M
S
H
I
L
E
C
F
E
S
R
G
-------------------------
V
A
E
V
L
--
V
A
E
Y
N
N
-
P
D
---------------------------------------------------------------------------------------------------
21
Fugue
54.90
9%
-97
- C3 -
3NOW
-
?
A:
[138-923]
---------------------------------N
A
K
T
S
T
K
V
K
Q
M
M
D
L
T
F
D
L
A
---
T
P
I
D
K
R
R
A
A
A
N
N
L
V
V
L
-
A
K
E
Q
T
------
G
A
E
----------------
L
L
Y
K
D
H
C
I
A
K
-------------
V
A
S
L
T
K
V
E
K
D
Q
D
I
Y
--------------
V
N
M
---
V
H
L
V
A
A
L
C
E
NS
V
E
R
T
K
G
V
L
T
E
L
G
V
P
---------
W
F
M
R
V
L
D
--
Q
KHEN
C
V
S
T
A
Q
F
C
L
Q
T
I
L
N
A
L
S
G
LKNKPDSKPD
K
E
L
-----
C
T
R
N
N
R
-
E
I
D
T
L
L
T
C
L
V
Y
S
I
TDRTIS
G
A
A
R
D
G
V
I
E
L
I
T
R
N
VHYT
A
L
E
W
A
E
R
--------
L
V
E
I
R
--------
G
L
C
R
L
L
D
V
C
S
-
E
------
L
E
DYKYESA
M
D
I
T
G
S
S
S
T
I
A
S
V
C
L
A
R
I
Y
E
--------
N
M
Y
Y
D
-
E
A
K
A
R
F
T
D
Q
I
D
E
Y
I
K
D
K
L
L
A
P
D
M
E
S
K
-----
V
R
V
T
V
A
I
T
A
L
L
N
G
P
L
D
V
G
N
Q
V
V
------
A
R
E
G
I
L
Q
M
I
L
A
M
A
-
T
T
----
D
D
E
L
Q
Q
R
V
A
C
E
C
L
I
A
A
S
S
K
-----------------
K
D
K
A
K
A
L
C
E
Q
G
-----------------------
V
D
I
L
K
R
L
Y
H
S
K
N
D
G
I
R
V
R
A
L
V
G
L
C
K
L
G
S
Y
G
G
Q
D
A
A
I
R
P
F
G
D
G
--
A
A
L
K
L
A
E
A
--
C
R
R
F
---
L
I
K
P
G
K
DKD
I
R
R
W
A
A
D
G
L
A
Y
L
T
L
D
A
--
E
C
K
E
K
L
---
I
-
E
D
K
A
S
I
H
A
L
M
D
L
A
R
G
G
N
Q
S
C
L
Y
-------------------------------------
G
-
V
V
T
T
F
V
N
L
C
N
A
--
Y
EKQ
E
M
L
P
EMIELAKFAKQ
H
I
P
E
EH
E
L
------------
D
D
V
-
D
F
I
N
-------
K
-------
R
I
T
V
L
A
N
E
G
I
T
T
------------------
A
L
C
A
L
A
K
--
T
E
S
H
N
S
Q
--
E
L
I
A
R
V
---
L
N
-
A
-------
V
C
G
L
K
E
L
--
R
G
K
V
V
Q
E
G
G
-
V
K
A
L
L
------
R
M
A
L
EG
T
E
K
G
----------
K
R
H
A
T
Q
A
L
--
A
R
I
G
---
I
T
I
N
P
E
---------------
V
S
F
S
G
Q
R
S
L
D
V
I
--------------------
R
P
L
L
N
L
L
Q
QD-
C
T
A
--------------------
L
E
---
N
F
E
S
L
M
A
L
T
-
N
------
L
A
S
M
N
E
S
V
R
Q
R
I
I
K
E
Q
G
V
S
K
I
E
Y
Y
L
M
E
D
H
L
Y
L
T
R
------------
A
A
A
Q
C
L
-------------
C
N
L
V
M
S
E
D
V
I
-
K
M
-
F
E
G
N
N
-
D
R
V
K
F
L
A
L
L
C
E
-------------------------
D
E
D
E
E
--
T
A
-
T
A
C
-
A
G
A
L
A
I
I
T
S
V
S
V
K
C
C
E
K
I
L
A
IAS
W
L
D
I
L
H
T
L
I
A
NPS
P
A
V
Q
H
R
G
I
V
I
I
L
N
M
I
N
AG
E
E
I
A
K
K
L
F
E
T
D
I
M
E
L
L
S
G
L
GQLPDDTR
A
K
A
R
E
V
A
T
Q
C
L
A
A
A
E
R
Y
R
I
I
3
PsiBlast_PDB
47.16
25%
-138
- C7 -
4LDS
-
?
A:
[235-426]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
G
-------------------------------------
R
-
I
L
I
V
----
G
C
I
--
F
------------------------
A
I
F
Q
Q
F
I
GINAVIF
Y
S
S
-
S
I
F
A
KAGLGE
A
A
-------
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
VVDK-----
I
D
R
K
-
K
L
--
L
V
G
G
N
I
G
--
M
I
A
S
L
L
---
I
M
-
A
I
L
I
W
T
IG
I
A
S
S
A
W
I
--
I
I
V
C
L
S
L
F
I
-
V
--
F
F
------
G
I
S
W--
G
P
V
L
----------
W
V
M
L
P
E
L
-----
F
P
---
M
-
R
A
R
G
---------------
A
A
T
G
----
I
S
A
L
--------------------
V
L
N
I
G
T
L
I
---
V
S
L
--------------------
F
F
---
P
I
L
S
D
A
L
S
T
-
E
------
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
-
F
V
I
K
F
L
P
E
T
R
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
39.70
21%
-160
- C7 -
4J7C
-
KTRB_BACSU
I:
[64-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
W
I
D
-------------------------------------
A
-
L
F
T
A
A
S
A
T
T
V
T
GL
A
------------------------
V
V
------------
D
T
G
-
T
Q
F
T
-------
V
FGQTVIM
G
L
I
Q
I
G
G
L
G
F
M
T
------------------
F
A
V
L
I
V
M
--
I
L
--
K
I
G
--
L
K
E
R
M
L
---
V
Q
E
A
-------
L
N
Q
P
T
----
I
G
G
V
I
G
L
V
K
-
V
L
F
L
F
------
S
I
S
---
I
E
L
I
----------
A
A
L
I
L
S
I
R
--
L
-
V
P
----------------------------
Q
Y
G
W
S
S
G
L
--------------------
F
A
S
L
F
H
A
I
---
S
A
F
--------------------
N
N
---
A
G
F
S
L
W
P
D
N
-
L
------
M
S
Y
V
G
D
P
T
V
N
L
V
I
T
F
-
L
F
I
T
G
G
I
G
F
T
V
L
F
D
V
M
K
N
------------
R
R
F
K
T
F
-------------
S
L
H
T
K
L
M
L
T
G
-
T
L
-
M
L
N
A
I
-
A
M
L
T
V
F
I
L
E
Y
S
-------------------------
N
P
G
T
L
--
G
H
-
L
H
I
-
V
D
K
L
W
A
S
Y
F
--------------------------------------------------------------------------------------------
4
PsiBlast_PDB
34.78
29%
-50
- C7 -
4M58
-
?
A:
[95-184]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
F
G
D
G
G
I
--
L
------------------------
A
L
------------
G
A
N
-
S
F
N
M
-------
A
-------
F
I
A
P
F
V
G
Y
G
I
Y
R
------------------
L
M
L
S
L
K
L
N
K
V
L
S
S
A
I
G
--
G
Y
V
G
I
N
---
A
A
-
A
-------
L
A
---------
T
A
I
E
L
G
L
-
Q
P
L
L
F
------
H
T
A
---
N
G
T
P
----------
L
Y
F
P
Y
G
L
N
--
V
A
I
P
---
A
M
M
F
A
H
---------------
L
T
V
A
G
I
V
E
A
V
I
T
--------------------
G
L
V
V
Y
Y
L
Q
---
K
V
D
--------------------
E
E
---
N
I
L
H
K
F
S
Y
R
-
L
------
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
32.15
16%
117
- C6 -
1Z56
2
LIF1_YEAST
A:
[159-235]
--------------------------------------------------
A
D
---
K
L
Y
K
D
I
C
C
V
N
D
S
Y
R
N
IK
E
S
D
S
S
------
N
R
N
----------------
R
V
E
Q
L
A
R
E
R
E
-------------
L
L
D
K
L
L
E
T
R
D
E
R
T
R
--------------
A
M
M
---
V
T
L
L
N
E
K
K
K
------
K
I
R
E
L
H
E
I
L
R
---------
Q
N
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
31.61
35%
32
- C7 -
4RNG
-
?
A:
[10-66]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
I
I
A
G
--
A
I
T
T
S
A
---
L
I
-
P
-------
Q
A
L
K
I
Y
K
--
T
K
S
A
R
D
V
S
L
-
A
M
F
I
F
------
M
A
I
---
G
I
T
L
----------
W
F
F
Y
G
V
L
I
--
K
E
I
P
---
V
I
L
A
N
L
---------------
I
S
L
I
L
I
F
L
I
I
F
M
--------------------
K
I
R
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
30.91
18%
93
- C5 -
1DL0
-
TK1C_HADVE
A:
[1-37]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
C
T
G
A
D
R
P
C
-
A
A
-
C
C
P
-
C
-
C
P
G
T
S
C
K
A
E
---------------------------
S
N
G
V
S
--
Y
C
-
R
K
D
-
E
P
---------------------------------------------------------------------------------------------------
12
HHSearch
26.99
32%
90
* C7 *
2LOR
-
TM141_HUMAN
A:
[48-78]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
M
F
I
Q
R
K
F
P
Y
P
L
Q
W
S
--------------------------------------
L
-
L
V
A
V
V
A
G
S
V
V
S
--
Y
------------------------
G
V
------------
T
R
V
-
E
S
E
K
-------
C
-------
N
N
L
W
L
F
L
E
T
G
Q
L
------------------
P
K
D
R
S
T
D
--
Q
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
26.71
14%
164
- C6 -
1OJH
1
?
A:
[5-56]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
S
L
E
Q
Q
F
S
I
R
S
F
A
T
Q
V
Q
N
M-----
S
H
D
Q
A
K
D
F
L
V
K
L
Y
-
E
Q
M
---
V
V
R
E
A
T
Y
Q
E
L
L
K
H
Q
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
26.07
25%
2397
- C1 -
1DL0
-
TK1C_HADVE
A:
[12-19]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
C
P
C
C
P
-------------------------
G
T
S
C
K
--
A
E
-
S
N
G
-
V
S
Y
C
R
K
D
E
P
--------------------------------------------------------------------------------------------
13
HHSearch
24.28
16%
356
- C7 -
2L6W
-
PGFRB_HUMAN
A:
[19-37]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
T
I
I
S
L
I
I
-
L
I
M
L
W
Q
K
--
K
P
R
Y
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
21.11
21%
185
- C7 -
2OAR
-
MSCL_MYCTA
A:
[39-67]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------
L
-
A
V
A
V
V
I
G
T
A
F
T
--
A
------------------------
L
V
------------
T
K
---
F
T
D
-------
S
-------
I
I
T
P
L
I
N
R
I
G
V
N
------------------
A
Q
S
D
V
G
I
--
L
R
I
G
I
G
G
--
G
Q
T
I
D
L
---
N
V
-
L
-------
L
S
A
A
I
N
F
--
F
L
I
A
F
A
V
Y
F
-
L
V
V
L
P
------
Y
N
T
---
L
R
K
K
----------
G
E
V
E
Q
P
G
D
--
T
Q
V
V
---
L
L
T
E
I
R
---------------
D
L
L
A
Q
T
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
17.05
14%
3202
- C2 -
1M4F
-
A:
[8-14]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
C
C
G
C
C
H
-------------------------
R
S
K
C
G
--
M
C
-
C
K
T
------------------------------------------------------------------------------------------------------
7
HHSearch
16.62
31%
699
- C7 -
2LUG
-
A:
[9-21]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
P
V
-
V
H
F
F
K
------
N
I
V
---
T
P
R
T
----------
P
P
P
S
Q
G
K
G
--
R
G
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------