@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S22AC_HUMAN: (2015-12-09 )
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------......-...10........20..-----..---....30--..----------......40........50....-....60........70........80........90........100.......110.......120-.-.......130------...-.----...-.140...-----....150.......160.......170-...---.....-------.---180....--...190-----------------.-------------.---.----.-.-----...200.......-----------210----...--....220---....--------...----230.--..---....240..------.....250.-----------..-----------------------------.---.-----------..------260...-------------...---.270...-.-.--..280.......290.......300......-.310....-------------.-..320.....----..--330.......340......--------.350-...----....360---------------......-..----------------370------.-.----..--..---.-----------.------380--------------.....---------..390----........--.400.....--..--410...---...--.----420...-...--.430.......440...-------....-450-----.-......460......---.----470-....-...480.....--..-.490-...---------..-------...500.....-----------...510.......520.......530-......----------------------.540.......550.---------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
A
F
S
E
L
-
L
D
L
VGG
L
G
R
F
Q
V
L
Q
T
M
A
-----
L
M
---
V
S
I
M
W
L
--
C
T
----------
Q
S
M
L
E
N
F
S
AAVPSHRCWAPLLD-NST
A
Q
A
S
I
LGSLSP
E
A
L
L
A
I
SIPPGPNQR
P
H
Q
C
R
RFRQPQ
W
Q
L
LDPNATATSWSEADTEPCVDG
W
V
--Y-DR
S
I
F
T
S
T
I
-------
V
A
K
-
W
----
N
L
V
-CDS
H
A
L
K
-----
P
M
A
Q
S
I
Y
L
A
G
I
L
V
GAAACGPASDRF---G
R
R
---
L
V
L
T
W
-------
S
---
Y
L
Q
M
A
V
M--GT
A
A
A------------------F-------------A---P----A-
F
-----
P
V
Y
C
L
F
R
F
L
L
A
F
A
-----------
V
A
G
----
V
MM--NT
G
T
L
L
M
---
E
WTA--------ARA----R
P
L
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--
M
T
---
L
N
SLGFSFG------H
G
L
T
A
A
V
A
Y-----------GV-----------------------------
R
---
D
-----------
W
T
------
L
L
Q
L
V
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TTGRL
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W
R
V
AAINGK-GAVQDTL
T
-------------
P
-
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L
L
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A
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E
----LS--MGQP
P
A
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RMPG
L
R
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--------
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I
-
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-------
Q
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L
L
Q
--------------
M
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---------VDI------
P
A
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----
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N
TL-V
P
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LGLGGV-------GA
A
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-----
T
-
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L
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L
R
M
T
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Y-GT
V
P
V
-----------
L
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L
A
A
L
LLPETQSLPL
P
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T
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Q
D
V
Q
N
-
Q
A
V
K
K
A----------------------THGTL
G
N
S
V
L
KSTQF---------------------------------------------------------------
17
Fugue
92.63
16%
-114
- C2 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
S
S
Y
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T
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---
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A
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M
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---
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L
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--
T
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L
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T
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Y
T
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A
P
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A
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M
L
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-------
A
M
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W
-
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P
V
-----
C
W
V
L
L
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A
---
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----
A
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A
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W
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K
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A
H
F
H
N
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P
E
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L
E
-
E
L
E
A
L
W
----------------------
E
-----------------------------------------------------------------------------
23
Fugue
90.62
20%
-98
- C2 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
I
F
S
-
I
T
L
V
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L
G
G
L
L
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R
---------------------------------------------------------------
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-----
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G
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L
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------
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-----------------------------
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---
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A
S
W
L
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M
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A
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A
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Y
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A
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M
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V
A
A
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-----
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L
L
S
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I
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P
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A
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---
L
----
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A
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V
A
A
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L
A
N
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M
M
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D
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K
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A
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W
K
F
V
P
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---------------------------------------------
K
G
K
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L
---------------------------------------------------------------
21
Fugue
76.27
18%
-119
- C2 -
3BZC
-
?
A:
[1-730]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
D
S
I
N
T
R
I
A
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L
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A
L
P
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T
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A
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V
K
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EVDIPRN
R
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MRMSDTPG
1
PsiBlast_PDB
74.87
25%
-101
- C2 -
4J05
-
?
A:
[311-520]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
--------
R
N
L
L
G
S
M
L
----
G
W
F
L
V
D
----------------
I
A
F
Y
G
I
-
N
L
----------------
N
Q
-------
S
-
V
----
V
L
--
A
Q
---
I
G
FAGKTGD
V
Y
D
K
------
L
F
Q
--------------
L
A
T
G
N
---------
I
I
V
T
A
L
G
F
L
P
G
Y
Y
F
T
L
F
--
L
I
D
I
V
G
R
K
K
--
L
Q
--
F
M
G
F
I
M
---
S
G
L
F
L
A
----
I
L
A
G
E
I
-
D
H
I
--
G
K
G
P
L
L
A
C
F
T
F
M
Q
F
F
F
N
-------
F
G
A
N
-
T
T
T
-----
F
-
I
V
A
A
E
L
F
P
T
R
I
R
A
S
A
---
H
----
G
I
S
-
A
A
A
G
-
K
C
G
A
I
-
L
S
S
L
V
F
N
Q
L
-
K
A
-
K
-
I
G
T
---------
S
A
-------
V
L
W
I
F
-
F
S
T
C
I
-----------
L
G
F
I
S
T
F
L
I
D
E
T
M
G
V
D
-
P
D
E
-
K
D
L
E
E
-
R
R
A
R
------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.00
22%
-117
- C2 -
4JA3
-
XYLE_ECOLI
A:
[26-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
-
Q
----
N
L
S
E
S
A
A
N
S
L
L
-----
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
---
G
R
R
---
D
S
L
K
I
-------
A
---
A
V
L
F
F
I
S
--
G
V
G
S
A
------------------
W
PELGF
T
S
I
N
P
D
N
T
V
---
P
----
V
-
Y
LAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
-----------
V
G
L
----
A
S
M
--
L
S
P
M
Y
I
A
---
E
L
A
P
--------
A
H
I
----
R
G
K
L
--
V
S
---
F
N
Q
F
A
I
I
F
G
------
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
T
-----------------------------
D
---
G
-----------
W
R
------
Y
M
F
A
S
E
-------------
C
I
P
A
L
-
L
F
L
M
L
L
Y
-
T
-----
V
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
---------
M
G
N
T
L
A
-------------
T
-
Q
A
-
V
Q
E
I
K
H
S
----
L
D
--
H
G
R
--------------
G
V
--------
I
V
I
G
-
V
M
L
----
S
I
F
Q
-------------------
Q
F
V
G
I
-
N
V
----------------
V
L
Y
Y
A
PEV----------S-
T
D
---
I
-----------
A
------
L
L
Q
T
-------------
I
I
V
G
V
---------
I
N
L
------
T
F
T
V
L
A
I
M
--
T
V
D
K
F
G
R
K
P
--
L
Q
--
I
I
G
A
L
G
---
M
A
I
--
G
----
M
F
S
L
G
T
-
A
F
Y
--
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
-------
A
F
A
M
-
S
W
G
-----
P
-
V
C
W
V
L
L
S
E
A
L
A
I
A
V
A
---
A
----
Q
W
L
-
A
N
Y
F
-
V
S
W
T
F
-
P
M
M
D
K
--
N
S
-
H
N
-
G
-
F
S
Y
---------
W
I
-------
Y
G
C
M
G
-
V
L
A
A
L
-----------
F
M
W
K
F
V
P
E
-----------------------------------------------------------------------------------------------------------------------------
22
Fugue
72.88
18%
-83
- C2 -
3WOL
7
DAPB2_PSEMX
A:
[1-696]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEGMWVP
Q
Q
L
P
E
I
-
A
G
P
L
K
K
A
G
L
K
L
S
P
Q
Q
I
S
DLTGD
P
M
---
G
A
V
V
A
L
GG
C
T
----------
A
S
F
V
S
P
N
G
L
V
V
T
N
H
H
C
A
Y
G
A
I
Q
L
N
S
T
A
E
N
N
L
I
K
N
G
F
N
A
P
T
T
A
D
E
V
S
A
G
P
N
A
R
V
F
V
L
D
E
I
T
D
V
T
K
D
A
K
A
A
I
A
A
A
G
D
D
A
L
A
R
T
K
A
L
E
A
-----
F
-
E
K
K
L
I
A
D
C
--------
E
A
E
-
A
----
G
F
R
-
C
R
L
Y
S
F
S
GGN
T
Y
R
L
F
K
N
L
E
I
K
D
V
R
L
A
Y
A
P
P
G
S
V
G
K
F
G
---
G
D
I
---
D
N
W
M
W
PRHTGD
F
A
---
F
Y
R
A
Y
V
G
KD
G
K
P
A
A
------------------
F
-------------
S
---
K
----
D
-
N
-----
V
P
Y
-
Q
P
K
H
W
L
K
F
A
D
Q
P
L
G
AG
D
F
V
M
V
A
G
----
Y
P
G
--
S
T
N
R
Y
A
L
---
A
A
E
F
--------
D
N
T
----
A
Q
W
----
T
---
Y
P
T
I
A
R
H
Y
K
------
N
Q
I
A
M
V
E
A
A
-----------
G
K
-----------------------------
Q
---
N
-----------
A
D
------
I
Q
V
K
----------------------------------
Y
A
A
T
M
A
G
W
N
N
T
S
K
N
Y
D
G
Q
L
E
G
F
K
R
I
D
A
A
G
Q
K
-
L
R
E
E
A
A
V
L
-------------
G
-
W
L
K
G
Q
G
A
K
G
Q
----
P
A
--
L
D
A
H
A
K
L
L
D
L
L
E
Q
S
K
A
T
R
D
--------
R
D
L
T
-
L
A
L
F
N
N
T
A
M
L
G
S
A
----------------
T
Q
L
Y
R
L
-
S
I
E
R
E
K
PNAERESGYQER
D
L
-------
P
-
A
----
I
E
--
G
G
---
L
-----------
K
------
Q
L
E
RRYV
A
A
M
D
R
Q
L
Q
E
Y
W
L
N
E
Y
---------
I
K
L
------
P
A
D
Q
R
V
A
A
--
V
D
A
W
L
G
G
N
D
-------
A
A
A
V
K
---
R
A
L
--
D
----
R
L
A
G
T
K
-
L
G
S
--
T
E
E
R
L
K
W
F
A
A
--
D
R
K
A
F
-------
E
A
S
N
-
D
P
A
-----
I
-
Q
Y
A
V
A
V
M
P
T
L
L
K
L
E
Q
E
R
K
T
----
R
A
G
-
E
N
L
A
-
A
R
P
V
Y
-
L
Q
A
L
A
--
D
Y
-
K
K
-
S
-
Q
G
E
---------
F
V
Y
P
DANL
S
L
R
I
T
F
-
G
N
V
M
G
Y
A
PKDG
M
E
Y
T
P
F
T
T
L
E
G
V
V
A
K
E
T
G
Q
D
P
F
-
D
S
P
K
A
L
L
D
-
A
V
A
A
K
R
YGGLEDKRIGSVPV
N
Y
L
S
D
L
D
I
T
G
G
N
S
G
S
P
V
L
D
A
H
G
K
LV
G
L
A
F
DGNWESVSSNWVFDPKM
T
R
M
I
A
V
D
G
R
Y
L
R
W
I
M
Q
EVYPA
P
Q
L
L
K
E
M
NV----------
5
PsiBlast_PDB
72.83
22%
-113
- C2 -
4GC0
4
XYLE_ECOLI
A:
[26-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
-
Q
----
N
L
S
E
S
A
A
N
S
L
L
-----
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
---
G
R
R
---
D
S
L
K
I
-------
A
---
A
V
L
F
F
I
S
--
G
V
G
S
A
------------------
W
PELGFTSINPDNT
V
---
P
----
V
-
Y
LAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
-----------
V
G
L
----
A
S
M
--
L
S
P
M
Y
I
A
---
E
L
A
P
--------
A
H
I
----
R
G
K
L
--
V
S
---
F
N
Q
F
A
I
I
F
G
------
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
T
-----------------------------
D
---
G
-----------
W
R
------
Y
M
F
A
S
E
-------------
C
I
P
A
L
-
L
F
L
M
L
L
Y
-
T
-----
V
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
---------
N
T
L
A
-------------
T
-
Q
A
-
V
Q
E
I
K
H
S
----
L
D
--
H
G
R
K
T
---
G
G
R
L
L
M
F
G
V
G
V
--------
I
V
I
G
-
V
M
L
----
S
I
F
Q
-------------------
Q
F
V
G
I
-
N
V
----------------
V
L
Y
Y
A
P
E
V
F
K
-
T
----
L
G
AS
T
D
---
I
-----------
A
------
L
L
Q
T
-------------
I
I
V
G
V
---------
I
N
L
------
T
F
T
V
L
A
I
M
--
T
V
D
K
F
G
R
K
P
--
L
Q
--
I
I
G
A
L
G
---
M
A
I
--
G
----
M
F
S
L
G
T
-
A
F
Y
--
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
-------
A
F
A
M
-
S
W
G
-----
P
-
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
---
G
----
K
A
L
-
A
I
A
V
-
A
A
Q
W
L
-
A
N
Y
F
V
--
S
W
-
T
F
-
P
-
M
M
D
---------
K
N
-------
S
W
L
V
A
-
H
F
H
N
G
-----------
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
-
K
T
L
E
E
L
----------------------
E
A
L
W
E
-------------------------------------------------------------------------
4
PsiBlast_PDB
72.56
22%
-109
- C2 -
4GBZ
4
XYLE_ECOLI
A:
[26-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
-
Q
----
N
L
S
E
S
A
A
N
S
L
L
-----
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
---
G
R
R
---
D
S
L
K
I
-------
A
---
A
V
L
F
F
I
S
--
G
V
G
S
A
------------------
W
PELGFTSINPDNT
V
---
P
----
V
-
Y
LAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
-----------
V
G
L
----
A
S
M
--
L
S
P
M
Y
I
A
---
E
L
A
P
--------
A
H
I
----
R
G
K
L
--
V
S
---
F
N
Q
F
A
I
I
F
G
------
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
T
-----------------------------
D
---
G
-----------
W
R
------
Y
M
F
A
S
E
-------------
C
I
P
A
L
-
L
F
L
M
L
L
Y
-
T
-----
V
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
---------
N
T
L
A
-------------
T
-
Q
A
-
V
Q
E
I
K
H
S
----
L
D
--
H
G
R
K
T
---
G
G
R
L
L
M
F
G
V
G
V
--------
I
V
I
G
-
V
M
L
----
S
I
F
Q
-------------------
Q
F
V
G
I
-
N
V
----------------
V
L
Y
Y
A
P
E
V
F
K
-
T
----
L
G
AS
T
D
---
I
-----------
A
------
L
L
Q
T
-------------
I
I
V
G
V
---------
I
N
L
------
T
F
T
V
L
A
I
M
--
T
V
D
K
F
G
R
K
P
--
L
Q
--
I
I
G
A
L
G
---
M
A
I
--
G
----
M
F
S
L
G
T
-
A
F
Y
--
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
-------
A
F
A
M
-
S
W
G
-----
P
-
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
---
G
----
K
A
L
-
A
I
A
V
-
A
A
Q
W
L
-
A
N
Y
F
V
--
S
W
-
T
F
-
P
-
M
M
D
---------
K
N
-------
S
W
L
V
A
-
H
F
H
N
G
-----------
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
-
K
T
L
E
E
L
----------------------
E
A
L
W
E
-------------------------------------------------------------------------
3
PsiBlast_PDB
71.81
22%
-110
- C2 -
4GBY
4
XYLE_ECOLI
A:
[26-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
-
Q
----
N
L
S
E
S
A
A
N
S
L
L
-----
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
---
G
R
R
---
D
S
L
K
I
-------
A
---
A
V
L
F
F
I
S
--
G
V
G
S
A
------------------
W
PELGFTSINPDNT
V
---
P
----
V
-
Y
LAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
-----------
V
G
L
----
A
S
M
--
L
S
P
M
Y
I
A
---
E
L
A
P
--------
A
H
I
----
R
G
K
L
--
V
S
---
F
N
Q
F
A
I
I
F
G
------
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
SGD
A
S
W
L
N
T
-----------------------------
D
---
G
-----------
W
R
------
Y
M
F
A
S
E
-------------
C
I
P
A
L
-
L
F
L
M
L
L
Y
-
T
-----
V
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
---------
N
T
L
A
-------------
T
-
Q
A
-
V
Q
E
I
K
H
S
----
L
D
--
H
G
R
K
T
---
G
G
R
L
L
M
F
G
V
G
V
--------
I
V
I
G
-
V
M
L
----
S
I
F
Q
-------------------
Q
F
V
G
I
-
N
V
----------------
V
L
Y
Y
A
P
E
V
F
K
-
T
----
L
G
AS
T
D
---
I
-----------
A
------
L
L
Q
T
-------------
I
I
V
G
V
---------
I
N
L
------
T
F
T
V
L
A
I
M
--
T
V
D
K
F
G
R
K
P
--
L
Q
--
I
I
G
A
L
G
---
M
A
I
--
G
----
M
F
S
L
G
T
-
A
F
Y
--
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
-------
A
F
A
M
-
S
W
G
-----
P
-
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
---
G
----
K
A
L
-
A
I
A
V
-
A
A
Q
W
L
-
A
N
Y
F
V
--
S
W
-
T
F
-
P
-
M
M
D
---------
K
N
-------
S
W
L
V
A
-
H
F
H
N
G
-----------
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
-
K
T
L
E
E
L
----------------------
E
A
L
W
E
-------------------------------------------------------------------------
28
HHSearch
67.71
16%
-119
- C2 -
3WDO
-
?
A:
[39-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
-
Q
----
G
A
S
----
E
A
L
I
-----
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
---
G
R
K
---
P
L
I
V
G
-------
G
---
L
A
V
F
A
A
G
--
S
V
I
A
A
------------------
L
-------------
S
---
D
----
S
-
I
-----
W
G
I
I
L
G
R
A
L
Q
G
S
G
-----------
A
------
I
A
A
--
A
V
M
A
L
L
S
---
D
L
T
R
--------
E
Q
N
----
R
T
K
A
--
M
A
---
F
I
G
V
S
F
G
I
T
------
F
A
I
A
M
V
L
G
P
-----------
I
I
T
H
K
--------------------------
L
---
G
-----------
L
H
------
A
L
F
W
M
I
-------------
A
I
L
---
A
T
T
G
I
A
L
T
I
-
W
--
V
V
P
N
S
S
T
H
V
L
N
R
E
---
S
---------------------------------------------------------
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
--------
L
N
F
G
-
I
M
C
----
L
H
M
L
L
M
----------------
S
T
F
V
A
L
-
P
G
----------------
Q
L
-------
A
-
D
----
A
G
--
F
P
---
A
-----------
A
E
H
W
K
V
Y
L
A
T
--------------
M
L
I
A
F
---------
G
S
V
------
V
P
F
I
I
Y
A
E
--
V
K
R
K
M
K
Q
----
V
F
--
V
F
C
V
G
L
---
I
V
V
--
A
----
E
I
V
L
W
N
-
A
Q
T
---
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
-------
N
L
M
E
-
A
L
L
-----
P
-
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
---
M
----
G
V
Y
-
S
T
S
Q
-
F
L
G
V
A
-
I
G
G
S
L
--
G
G
W
I
D
-
G
M
F
D
G
---------
Q
G
-------
V
F
L
A
G
-
A
M
L
A
A
-----------
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
-
A
A
N
E
A
L
----------------------
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
---------------------------------------------------------------
27
HHSearch
64.62
12%
-124
- C2 -
1PW4
-
GLPT_ECOLI
A:
[51-430]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
P
Y
L
--------
V
E
-
Q
----
G
F
S
----
R
G
D
L
-----
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
---
N
P
R
---
V
F
L
P
A
-------
G
---
L
I
L
A
A
A
V
--
M
L
F
M
G
------------------
F
-------------
V
---
P
W
A
T
S
S
-
I
-----
A
V
M
F
V
L
L
F
L
C
G
W
F
-----------
Q
G
M
----
G
W
P
--
P
C
G
R
T
M
V
---
H
W
W
S
--------
Q
K
E
----
R
G
G
I
--
V
S
---
V
W
N
C
A
H
N
V
G
------
G
G
I
P
P
L
L
F
L
-----------
L
G
M
AWF-------------------------
N
---
D
-----------
W
H
------
A
A
L
Y
M
P
-------------
A
F
C
---
A
I
L
V
A
L
F
A
F
-
A
--
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
------------------------------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
--------
I
A
I
A
-
N
V
F
----
V
Y
L
L
R
Y
----------------
G
I
L
D
W
S
-
P
T
----------------
Y
L
-------
K
-
E
V---
K
H
--
F
A
L
D
K
S
-----------
S
------
W
A
Y
--------------
F
L
Y
E
Y
---------
A
G
I
------
P
G
T
L
L
C
G
W
--
M
S
D
K
V
F
R
G
N
--
R
G
--
A
T
G
V
F
F
M
T
L
V
T
I
--
A
----
T
I
V
Y
W
M
-
N
P
A
--
G
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
-------
Y
G
P
V
-
M
L
I
-----
G
-
L
H
A
L
E
L
A
P
K
K
A
A
G
T
A
---
A
----
G
F
T
-
G
L
F
G
-
Y
L
G
G
S
V
A
A
S
A
I
--
V
G
Y
T
V
-
D
F
F
G
W
---------
D
G
-------
G
F
M
V
M
-
I
G
G
S
I
-----------
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.60
22%
-113
- C2 -
4JA4
-
XYLE_ECOLI
A:
[26-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
-
Q
----
N
L
S
E
S
A
A
N
S
L
L
-----
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
---
G
R
R
---
D
S
L
K
I
-------
A
---
A
V
L
F
F
I
S
--
G
V
G
S
A
------------------
W
PELGF
T
S
I
N
P
D
N
T
V
---
P
----
V
-
Y
LAGY
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
-----------
V
G
L
----
A
S
M
--
L
S
P
M
Y
I
A
---
E
L
A
P
--------
A
H
I
----
R
G
K
L
--
V
S
---
F
N
Q
F
A
I
I
F
G
------
Q
L
L
V
Y
C
V
N
Y
F
I
A
RSGD
A
S
W
L
N
T
-----------------------------
D
---
G
-----------
W
R
------
Y
M
F
A
S
E
-------------
C
I
P
A
L
-
L
F
L
M
L
L
Y
-
T
-----
V
P
E
S
P
R
W
L
M
----
Q
E
Q
A
E
G
I
L
R
K
I
---------
M
G
N
T
L
A
-------------
T
-
Q
A
-
V
Q
E
I
K
H
S
----
L
D
--
H
G
-----------
M
F
G
V
G
V
--------
I
V
I
G
-
V
M
L
----
S
I
F
Q
-------------------
Q
F
V
G
I
-
N
V
----------------
V
L
Y
Y
APEV------------------------------------
L
L
Q
T
-------------
I
I
V
G
V
---------
I
N
L
------
T
F
T
V
L
A
I
M
--
T
V
D
K
F
G
R
K
P
--
L
Q
--
I
I
G
A
L
G
---
M
A
I
--
G
----
M
F
S
L
G
T
-
A
F
Y
--
T
Q
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
-------
A
F
A
M
-
S
W
G
-----
P
-
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
---
G
----
K
A
L
-
A
I
A
V
-
A
A
Q
W
L
-
A
N
Y
F
V
--
S
W
-
T
F
-
P
-
M
M
D
---------
K
N
-------
S
W
N
G
F
-
S
Y
W
I
Y
-----------
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
-
E
A
L
W
E
-----------------------------------------------------------------------------------------------------
26
Fugue
64.04
13%
-111
- C2 -
3W3W
1
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
VQDDLPAW
P
E
L
L
Q
A
L
I
E
S
L
K
SGN
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
VD
I
N
S
I
L
P
I
F
Q
S
G
F
T
DAS
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
LPKSEWSKLGIL
L
P
S
L
L
N
S
L
P
R
F
L
D
D
GK
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
APKLFKDM
F
D
Q
I
I
Q
F
T
D
M
V
I
K
NKDLEP
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
EVSIDDDDA
A
E
W
I
E
SDDTDDEEE
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
LGGEYL
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
STE
W
R
E
R
F
A
A
M
M
A
L
S
S
A
AEGCA
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
NDPH
P
R
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
S
P
F
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
L
TSECT
S
R
V
Q
T
H
A
A
A
A
L
V
N
F
S
E
FASKDILEPY
L
D
S
L
L
T
N
L
-
L
V
L
L
Q
S
N
K
L
Y
V
Q
E
Q
A
L
T
-----
T
I
---
A
F
I
A
E
A
--
A
K
----------
N
K
F
I
K
Y
Y
D
T
L
M
P
--
L
L
L
N
V
L
K
V
-
N
S
V
L
K
G
K
C
M
E
C
A
T
---
L
I
G
F
A
V
G
---------
K
E
K
F
H
E
-
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
S
D
A
L
R
S
Y
L
E
Q
S
W
S
--
R
-
I
C
R
I
L
G
D
D
F
-------
V
P
L
-
L
----
P
I
V
-
I
P
P
L
L
I
T
A
K
---
A
T
Q
D
V
G
L
I
E
E
E
E
A
A
N
F
Q
Q
Y
P
D
W
D
V
V
Q
V
Q
G
K
H
---
I
A
I
H
T
-------
S
---
V
L
D
D
K
V
S
--
A
M
E
L
L
------------------
Q
-------------
S
---
Y
----
A
-
T
-----
L
L
R
G
Q
F
A
V
Y
V
K
E
V
-----------
M
E
E
----
I
A
L
--
P
S
L
D
F
Y
L
---
H
-
D
G
--------
V
R
A
----
A
G
A
T
--
L
I
---
P
I
L
L
S
C
L
L
A
------
A
E
E
L
V
L
L
W
H
-----------
K
A
-----------------------------
S
---
S
-----------
K
L
------
I
G
G
L
M
S
-------------
E
P
M
---
P
E
I
T
Q
V
Y
-
H
-
N
--
S
L
V
N
G
I
K
V
M
G
D
N
C
L
S
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
-
D
T
Y
E
R
M
Q
D
-------------
R
-
D
E
Y
N
E
D
F
T
D
E
----
D
L
--
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
G
H
Y
--------------------------------------------------------------------
L
-------
K
-
N
----
L
E
--
N
I
---
W
-----------
P
------
M
I
N
--------------
T
F
L
-----------
L
E
P
------
I
L
V
I
F
A
L
V
--
V
I
G
D
L
I
Q
Y
E
--
Q
T
---
A
S
M
K
N
---
A
F
I
--
P
----
K
V
T
E
C
L
-
I
S
P
--
D
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
-------
Y
A
P
S
-
T
----------
Y
A
D
V
C
I
P
T
L
D
T
L
V
Q
---
I
V
DGS
K
L
E
-
E
N
R
S
-
S
T
E
N
A
-
S
A
A
I
A
--
K
I
-
L
Y
-
A
-
Y
N
S
NIPD
T
Y
T
A
N
W
F
-------
K
T
L
P
T
-
I
T
D
K
E
-----------
A
A
S
F
N
Y
Q
F
L
S
Q
V
C
A
Q
S
N
I
S
A
V
V
D
S
V
I
-
Q
A
L
N
E
R
----------------------
S
L
-
T
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F--------------------------------------
29
HHSearch
60.41
12%
-115
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[45-406]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
I
L
L
P
Q
F
-------
Q
Q
A
-
F
----
T
L
T
----
N
F
Q
A
-----
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
---
S
Y
K
---
A
G
I
I
T
-------
G
---
L
F
L
Y
A
L
G
--
A
A
L
F
W
------------------
P
-------------
A
A
E
I
M
----
N
-
Y
-----
T
L
F
L
V
G
L
F
I
I
A
A
G
-----------
L
G
C
----
L
E
T
--
A
A
N
P
F
V
T
---
V
L
G
P
--------
E
S
S
----
G
H
F
R
--
L
N
---
L
A
Q
T
F
N
S
F
G
------
A
I
I
A
V
V
F
G
Q
-----------
S
L
ILSNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
---
S
-----------
V
Q
------
T
P
Y
M
I
I
-------------
V
A
I
---
V
L
L
V
A
L
L
-
I
-
M
L
T
K
F
P
A
L
Q
S
D
----
N
H
S
D
A
K
-------------------------------------------------------
Q
G
S
F
S
A
S
L
S
R
L
A
R
I
R
H
W
R
W
--------
A
V
L
A
-
Q
F
C
----
Y
V
G
A
Q
T
----------------
A
C
W
S
Y
L
-
I
R
----------------
Y
A
-------
V
E
E
I---
P
G
--
M
T
---
A
G
F
A
--------
A
------
N
Y
L
--------------
T
G
T
M
V
---------
C
F
F
------
I
G
R
F
T
G
T
W
--
L
I
S
R
F
A
P
H
K
--
V
L
--
A
A
Y
A
L
I
---
A
M
A
--
L
----
C
L
I
S
A
F
-
A
G
G
--
H
--
V
G
L
-
I
A
L
T
L
C
S
A
F
M
-------
S
I
Q
Y
-
P
T
I
-----
F
-
S
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
---
S
----
S
F
I
--
V
M
T
-
I
I
G
G
G
-
I
V
T
P
V
--
M
G
F
V
S
-
D
-
A
A
G
---------
N
I
-------
P
T
A
E
L
-
I
P
A
L
C
-----------
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.01
24%
-108
- C2 -
4PYP
1
GTR1_HUMAN
A:
[48-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
H
R
Y
-
G
E
S
I
L
P
T
T
L
-------
T
T
L
-
W
----
S
L
----------------
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
---
G
R
R
N
S
M
L
M
M
N
L
-------
L
---
A
F
V
S
A
V
L
--
M
G
F
S
K
------------------
L
-------------
G
---
K
----
S
-
F
-----
E
M
L
I
L
G
R
F
I
I
G
V
Y
-----------
C
G
-------
L
--
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
--------
T
A
L
----
R
G
A
L
--
G
T
---
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
-------------
G
N
-----------------------------
K
---
D
L----------
W
P
------
L
L
L
S
I
I
-------------
F
I
P
---
A
L
L
Q
C
I
V
-
L
-
P
--
F
C
P
E
S
P
R
F
L
L
I
N
------
R
N
E
E
N
R
A
K
S
V
L
K
K
-
L
R
G
T
A
D
V
T
-------------
H
-
D
--
L
Q
E
M
K
E
E
----
S
R
Q
M
M
R
E
K
K
V
T
I
L
E
L
F
R
S
P
A
Y
R
Q
--------
P
I
L
I
-
A
V
V
----
L
Q
L
S
Q
Q
----------------
L
S
G
I
N
A
-
V
F
----------------
Y
Y
-------
S
-
T
----
S
I
--
F
E
---
K
-----------
A
------
G
V
Q
--------------
Q
P
V
Y
A
---------
T
I
G
------
S
G
I
V
N
T
A
F
--
T
V
V
S
L
F
V
V
Q
--
R
A
--
G
R
R
T
L
H
---
L
I
G
--
L
----
A
G
M
A
G
C
-
A
I
L
--
M
T
I
A
L
A
L
L
E
Q
L
P
W
M
S
Y
L
-------
S
I
V
A
-
I
F
G
-----
F
-
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
---
V
----
A
E
L
-
F
S
Q
G
-
P
R
P
A
A
-
I
A
V
A
G
--
F
S
-
N
W
-
T
-
S
N
F
---------
I
V
-------
G
M
C
F
Q
-
Y
V
E
Q
L
-----------
C
G
P
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
-
T
---------------------------------------------------------------------------------------------------------
31
HHSearch
57.15
12%
-107
- C2 -
2CFQ
-
LACY_ECOLI
A:
[28-393]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
F
P
I
W
-------
L
H
D
I
N
----
H
I
S
----
K
S
D
T
-----
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
---
G
L
R
---
K
Y
L
L
W
-------
I
I
T
G
M
L
V
M
F
A
P
--
F
F
I
F
I
------------------
F
-------------
G
---
P
----
L
L
Q
-----
Y
N
I
L
V
G
S
I
V
G
G
I
Y
-----------
L
G
F
CFNA
G
A
P
--
A
V
E
A
F
I
E
---
K
V
S
R
----------
R
----
S
N
F
E
--
F
G
---
R
A
R
M
F
G
C
V
G
------
W
A
L
G
A
S
I
V
G
-----------
I
M
-----------------------------
F
T
I
-
N
-----------
N
Q
------
F
V
F
W
L
G
-------------
S
G
C
---
A
L
I
L
A
V
L
-
L
-
F
--
F
A
K
T
D
A
P
S
S
----
A
T
V
A
N
A
V
--------
G
A
----------------------------------
N
-----
H
--
S
A
F
S
L
K
L
A
L
E
L
F
R
Q
P
K
L
W
F
--------
L
S
L
Y
-
V
I
G
----
V
S
C
T
Y
D
----------------
V
F
D
Q
Q
F
-
A
N
----------------
F
F
-------
T
-
S
F
FAT
G
E
--
Q
G
T
R
V
F
-----------
G
------
Y
V
T
--------------
T
M
G
E
L
---------
L
N
A
------
S
I
M
F
F
A
P
L
--
I
I
N
R
I
G
G
K
N
--
A
L
--
L
L
A
G
T
I
---
M
S
V
--
R
----
I
I
G
S
S
F
-
A
T
S
--
A
--
L
E
V
V
I
L
K
T
L
H
M
F
E
V
-------
P
F
L
L
-
V
G
C
-----
F
-
K
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
---
Y
----
L
V
C
F
C
F
F
K
-
Q
L
A
M
I
-
F
M
S
V
L
--
A
G
N
M
Y
E
S
-
I
G
F
---------
Q
G
-------
A
Y
L
V
L
-
G
L
V
A
L
-----------
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
-
A
---------------------------------------------------------------------------------------------------------
30
HHSearch
56.80
16%
-97
- C2 -
2GFP
-
EMRD_ECOLI
A:
[29-359]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
I
A
D
M
-------
A
R
D
-
L
----
N
V
R
----
E
G
A
V
-----
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
---
G
R
R
---
P
V
I
L
V
-------
G
---
M
S
I
F
M
L
A
--
T
L
V
A
V
------------------
T
-------------
T
---
S
----
S
-
L
-----
T
V
L
I
A
A
S
A
M
Q
G
M
G
-----------
T
G
V
----
G
G
V
--
M
A
R
T
L
P
R
---
D
L
Y
E
--------
R
T
Q
----
L
R
H
A
--
N
S
---
L
L
N
M
G
I
L
V
S
------
P
L
L
A
P
L
I
G
G
-----------
L
L
-----------------------------
D
TM
W
N
-----------
W
R
------
A
C
Y
L
F
L
-------------
L
V
L
---
C
A
G
V
T
F
S
-
M
A
R
--
W
M
P
E
T
R
P
V
D
-----
A
P
R
---------------------------------------------------------
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
--------
Y
L
L
M
-
L
I
G
----
G
L
A
G
I
A
----------------
A
F
E
A
C
S
-
G
V
----------------
L
M
-------
G
-
A
V
---
L
G
--
L
S
---
S
M
T
V
--------
S
------
I
L
F
--------------
I
L
P
I
P
---------
A
A
F
------
F
G
A
W
F
A
G
R
--
P
N
K
R
F
S
T
L
M
--
W
Q
--
S
V
I
C
C
L
---
L
A
G
--
L
----
L
M
W
I
P
D
W
F
G
V
--
M
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
-------
G
M
L
F
-
P
L
A
-----
T
-
S
G
A
M
E
P
F
P
-
F
L
A
G
T
A
---
G
----
A
L
V
-
G
G
L
Q
-
N
I
G
S
G
-
V
L
A
S
L
--
S
A
M
L
P
-
Q
-
T
G
Q
---------
G
S
-------
L
G
L
L
M
-
T
L
M
G
L
-----------
L
I
V
L
C
W
L
P
L
----------------------------------------------------------------------------------------------------------------------------
19
Fugue
52.61
11%
-104
- C3 -
3IP4
-
GATB_STAAM
B:
[1-482]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
F
-
E
T
V
I
G
L
E
V
H
V
E
L
K
T
D
S
K
-----
M
F
---
S
P
S
P
A
H
--
F
G
----------
A
E
P
N
S
N
T
N
V
I
D
L
A
Y
P
G
V
L
P
V
V
N
-
K
R
A
V
D
W
A
M
R
A
A
M
A
L
N
M
E
I
A
------------
T
E
S
K
F
D
R
K
N
Y
F
Y
P
D
-
N
P
K
A
Y
Q
I
S
Q
F
D
Q
P
I
G
E
N
G
Y
I
--
D
I
E
V
D
G
E
T
K
R
I
-------
G
I
T
-
R
----
L
H
M
-
E
E
D
A
G
K
S
-----
T
H
K
G
E
Y
S
L
V
D
L
-----------
N
R
Q
---
G
T
P
---
L
I
E
I
V
-------
S
---
E
P
D
I
R
S
P
--
K
E
A
Y
A
------------------
Y
-------------
L
---
E
----
K
-
L
-----
R
S
I
I
Q
Y
T
-----
G
-----------
V
S
D
----
V
K
M
--
E
E
G
S
L
R
C
---
D
A
N
I
--------
S
L
R
P
Y
GQ
E
K
F
G
--
T
K
---
A
E
L
K
N
L
N
S
F
------
N
Y
V
R
K
G
L
E
Y
-----------
E
E
-----------------------------
K
---
R
-----------
Q
E
------
E
E
L
L
N
G
-------------
G
E
I
---
G
Q
E
T
R
R
F
-
D
-
E
--
S
T
G
K
T
I
L
M
R
V
K
E
G
S
D
D
Y
R
Y
F
P
--------------
E
P
D
I
V
-------------
P
-
L
Y
I
D
D
A
W
K
E
R
----
V
R
--
Q
T
I
P
--------
E
L
P
D
E
R
K
--------
A
K
Y
V
-
N
E
------------------------------
L
G
L
P
A
Y
----------------
D
A
-------
H
-
V
----
L
T
--
L
T
---
K
-----------
E
------
M
S
D
--------------
F
F
E
S
T
---------
I
E
H
GA----
D
V
K
L
T
S
N
W
--
L
M
G
--------
G
V
--
N
E
Y
L
N
K
---
N
Q
V
--
E
----
L
L
D
T
K
L
-
T
P
E
--
N
L
A
G
M
I
K
L
I
E
D
G
T
M
S
S
K
-------
I
A
K
K
-
V
F
P
-----
E
-
L
A
A
K
G
--
G
N
A
K
Q
I
M
E
---
D
----
N
G
L
-
V
Q
I
S
-
D
E
A
T
L
-
L
K
F
V
N
--
E
A
-
L
D
-
N
-
N
E
Q
---------
S
V
-------
E
D
Y
K
N
-
G
K
G
K
A
-----------
M
G
F
L
V
G
Q
I
M
K
A
S
K
G
Q
A
N
P
Q
L
V
N
Q
L
L
K
-
Q
E
L
D
K
R
----------------------
L
E
H
H
H
H
H
-----------------------------------------------------------------------
24
Fugue
49.44
17%
-80
- C2 -
2IMJ
2
?
A:
[5-162]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
------------------
V
-------------
R
---
P
----
P
-
L
-----
P
P
F
T
R
E
S
A
I
E
K
I
R
-----------
L
A
E
----
D
G
W
--
N
S
R
D
---------
P
--------
E
R
V
----
S
L
A
Y
TL
D
T
---
Q
W
R
N
R
A
E
F
A
------
H
N
R
E
E
A
K
A
F
-----------
L
T
-----------------------------
R
---
K
-----------
W
A
K
ELD
Y
R
L
I
K
E
L
W
-------------
A
F
T
DN
R
I
A
V
R
Y
A
Y
-
E
-
W
--
H
-
D
D
S
G
N
W
F
R
S
Y
G
N
E
N
W
E
F
D
E
-------
Q
G
L
M
A
R
R
F
A
C
I
N
-------------
D
M
P
I
K
A
Q
E
R
K
F
H
----
W
P
--
L
G
R
R
P
D
D
H
P
G
L
S
E
L
G
L
E
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
48.39
25%
-126
- C2 -
4LDS
-
?
A:
[52-191]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
---
G
R
R
---
R
L
V
M
L
-------
I
---
A
I
V
F
I
I
G
--
A
L
I
L
A
------------------
A
-------------
S
---
T
----
N
-
L
-----
A
L
L
I
I
G
R
L
I
I
G
L
A
-----------
V
G
G
----
S
M
S
--
T
V
P
V
Y
L
S
---
E
M
A
P
--------
T
E
Y
----
R
G
S
L
--
G
S
---
L
N
Q
L
M
I
T
I
G
------
I
L
A
A
Y
L
V
N
Y
-----------
A
F
-----------------------------
A
---
D
I
E
G
--------
W
R
------
W
M
L
G
L
A
-------------
V
V
P
---
S
V
I
L
L
V
G
-
I
-
Y
--
F
M
P
E
S
P
R
W
L
L
E
N
R
N
E
E
A
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
-
D
K
E
L
K
E
M
K
-------------
E
-
I
N
A
I
S
E
S
T
W
T
----
V
I
--
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
--------
Q
F
I
G
-
I
N
A
----
V
I
F
Y
S
S
----------------
S
I
F
A
K
A
-
G
L
----------------
G
E
-------
A
-
A
----
S
I
--
L
G
---
S
-----------
V
------
G
I
G
--------------
T
I
N
V
L
---------
V
T
I
------
V
A
I
F
V
V
D
K
--
I
D
R
K
K
L
L
V
G
--
G
N
--
I
G
M
I
A
S
---
L
L
I
--
M
----
A
I
L
I
W
T
-
I
G
I
--
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
-------
F
G
I
S
-
W
G
P
-----
V
-
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
---
A
----
A
T
G
-
I
S
A
L
-
V
L
N
I
G
-
T
L
I
V
S
--
L
F
-
F
P
-
I
-
L
S
D
---------
A
L
-------
S
T
E
W
V
-
F
L
I
F
A
-----------
F
I
G
V
L
A
M
I
F
V
I
K
F
L
P
E
T
R
G
------------------------------------------------------------------------------------------------------------------