@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S27A6_HUMAN: (2015-12-10 )
MLLSWLTVLGAGMVVLHFLQKLLFPYFWDDFWFVLKVVLIIIRLKKYEKRGELVTVLDKFLSHAKRQPRKPFIIYEGDIYTYQDVDKRSSRVAHVFLNHSSLKKGDTVALLMSNEPDFVHVWFGLAKLGCVVAFLNTNIRSNSLLNCIRACGPRALVVGADLLGTVEEILPSLSENISVWGMKDSVPQGVISLKEKLSTSPDEPVPRSHHVVSLLKSTCLYIFTSGTTGLPKAAVISQLQVLRGSAVLWAFGCTAHDIVYITLPLYHSSAAILGISGCVELGATCVLKKKFSASQFWSDCKKYDVTVFQYIGELCRYLCKQSKREGEKDHKVRLAIGNGIRSDVWREFLDRFGNIKVCELYAATESSISFMNYTGRIGAIGRTNLFYKLLSTFDLIKYDFQKDEPMRNEQGWCIHVKKGEPGLLISRVNAKNPFFGYAGPYKHTKDKLLCDVFKKGDVYLNTGDLIVQDQDNFLYFWDRTGDTFRWKGENVATTEVADVIGMLDFIQEANVYGVAISGYEGRAGMASIILKPNTSLDLEKVYEQVVTFLPAYACPRFLRIQEKMEATGTFKLLKHQLVEDGFNPLKISEPLYFMDNLKKSYVLLTRELYDQIMLGEIKL
Atome Classification :
(20 SA)
-.........10........20........30........40........-----------------50........60...-----.....70.....-----.-----.------.80-.........90......-..100.......110.......120.......130.......140.......150......------.160...--...-...----170..-.--....180--.----.......190---------------......-..200..-.---.....210.....--..220-.......230....--...240...-.--....----250...-------..-------....260.......270-..------.....280.....----.-.--290---.......300.......310.......320-..--....---.330--.-...-----..--...340.......350----.--...--...360.....-----..370..---.-----.--...380.......390.-.......400....-------...410.......420..-.....---430-...---..--....440.......450.......460.......470.......480.......490.......500-.......510......----.520--.........530--....-----.....---540....----..-----.550.-......560.......570.......580.......590.......600.......610.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
L
L
S
W
L
T
V
L
G
A
G
M
V
V
L
H
F
L
Q
K
L
L
F
P
Y
F
W
D
D
F
W
F
V
L
K
V
V
L
I
I
I
R
L
K
K
Y
E
K-----------------RG
E
L
V
T
V
L
D
K
F
L
S
H
A
-----KRQPRK
P
F
I
I
Y
E-----G-----
D
------
I
Y
--
T
Y
Q
D
V
D
K
RSS
R
V
A
H
V
F
L-NHSSLKKG
D
T
V
A
L
L
MSNEP
D
F
V
H
V
W
F
G
L
A
K
L
G
C
V
V
A
F
L
NTNIR
S
N
S
L
L
N
C
I
R
A
CGP
R
A
L
V
V------
G
A
--
D
L
L
--
G
T
V
-
E
E
I
----
L
P
S
L
S-E--N
I
S
V
W-G--M----KDSV
P
Q
G
V
I
----------------
S
L
K
E
K
L-STS-PDE-P---VPR
S
H
H
V
V
S
L
L
K
S--T
C
L
Y
I
-
F
TSGTTGL
P
K
A
A
V
I
--
S
Q
L
Q
-
V
LRG-
S
--
A
V
L
W
----
A
--FGC-------TA-------
H
D
I
V
Y
I
T
L
P
LYHSSA
A
I
-
L
G
------
I
S
G
C
V
E
LGA
T
C
V
L
----K-K--KF
S
---
A
S
Q
F
W
S
D
C
K
KY
D
V
T
V
F
Q
Y
I
G
E
L
C
R
Y
L
C
K
Q
S
-KR--EGEK---D
H
----
K
-
V
R
L
-----
A
I--GNG
I
R
S
D
V
W
R
E
F
L
D
RF----G--N
I
K
--
V
C
E
L
Y
AATES
S
-----
I
S
F
MNYT---G-----R--IGAIG
R
T
N
L
F
Y
K
L
L
S
-
T
-
F
D
L
I
K
Y
DFQKDEPM-------RNEQ
G
W
C
I
H
VKKGEP
G
L
L
-
I
S
RVN---A---KNP---FF--GYAGPYKH
T
K
D
K
L
L
C
D
V
FKKG
D
V
Y
L
NTG
D
L
I
V
QDQD
N
F
L
Y
F
WDRTG
D
T
F
R
WKGENV
A
T
T
E
V
A
D
V
I
G
M
-
L
D
F
I
Q
EANV
Y
G
V
A
I
SG----YE----GRAG
M
A
S
I
I
L----KPNT-----SL
D
L
E
---
K
V
Y
E
Q
V
V
----
T
F
-----
L
P
A
Y
A-C
P
R
F
L
R
I
Q
E
K
M
EAT
G
T
F
K
L
L
K
H
Q
L
V
E
DGFNPLKISE
P
L
Y
F
M
D
N
L
K
K
S
Y
V
L
L
T
R
E
L
Y
D
Q
I
MLGEIKL
6
PsiBlast_PDB
93.51
21%
-91
- C2 -
1RY2
1
ACS1_YEAST
A:
[68-631]
-------------------------
P
S
F
Q
N
N
A
W
F
L
--------------------------------
N
G
Q
L
N
A
C
Y
N
C
V
D
R
H
A
-----
L
K
T
P
N
K
K
A
I
I
F
E
-----
G
-----
D
EPGQ
G
Y
S
I
--
T
Y
K
E
L
L
E
E
V
C
Q
V
A
Q
V
L
T
-
Y
S
M
G
V
R
K
G
D
T
V
A
V
Y
M
P
M
V
P
E
A
I
I
T
L
L
A
I
S
R
I
G
A
I
H
S
V
V
F
A
G
F
S
S
N
S
L
R
D
R
I
N
D
G
D
S
K
V
V
I
T
T
D
E
S
N
R
G
G
--
K
V
I
--
E
T
K
-
R
I
V
----
D
D
A
L
R
-
E
--
T
P
G
V
R
-
H
--
V
L
V
Y
R
K
T
N
N
P
S
V
A
F
----------------
H
A
P
R
D
L
-
D
W
A
-
T
E
K
-
K
---
K
Y
K
T
Y
Y
P
C
T
P
V
D
S
ED
P
L
F
L
L
-
Y
T
S
G
S
T
G
A
P
K
G
V
Q
H
--
S
T
A
G
-
Y
L
L
G
-
A
L
L
T
M
R
Y
----
T
--
F
D
T
HQE
D
V
F
F
T
A
-------
G
D
I
G
W
I
T
G
H
T
Y
V
V
Y
G
P
L
-
L
--------
Y
G
C
----
A
T
L
V
F
----
E
-
G
--
T
P
A
YPN
Y
S
R
Y
W
D
I
I
D
E
H
K
V
T
Q
F
-
Y
V
A
P
T
A
L
R
L
L
K
R
A
-
G
D
--
S
Y
I
E
---
N
H
----
S
-
L
K
S
LR
C
L
G
S
V
--
G
E
P
I
A
A
E
V
W
E
W
Y
S
E
K
I
----
G
KN
E
I
P
--
I
V
D
T
Y
W
Q
T
E
S
G
-----
S
H
L
V
T
P
L
---
A
------------
G
G
V
T
P
M
K
P
G
S
A
-
S
-
F
P
F
F
G
I
D
A
V
V
L
D
P
N
-------
T
G
E
E
L
N
T
S
H
A
E
----
G
V
L
-
A
--
V
K
---
A
---
A
W
P
---
S
F
--
A
R
T
I
W
K
N
H
--
D
R
Y
L
D
T
Y
L
N
P
Y
P
G
Y
Y
F
T
G
D
G
A
A
K
D
K
D
G
Y
I
W
I
L
G
R
V
D
D
V
V
N
V
S
G
H
R
L
S
T
A
E
I
E
A
A
I
------
I
E
D
P
I
V
A
E
C
A
V
V
G
----
F
N
DDLT
G
Q
A
V
A
A
F
V
V
L
----
K
-----------
L
Q
---
D
I
K
K
H
L
V
F
T
V
R
K
D
-----
I
G
P
F
A
-
A
P
K
L
I
I
L
V
D
D
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
L
A
N
P
G
I
V
R
H
L
I
D
S
V
K
L
-----------------------
2
PsiBlast_PDB
91.35
23%
-103
- C2 -
3ETC
10
?
A:
[65-559]
--------------------------------------------------------------------------------
Y
A
-----
R
D
S
P
E
K
L
A
M
I
W
C
-----
D
-----
D
YG
N
E
K
-
I
F
--
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
-
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
------
I
A
ED
D
V
P
--
E
Q
V
-
D
E
A
----
H
A
E
C
G
-
D
I-
P
L
K
K
A
-
K
--
V
----
G
G
D
V
L
E
G
W
I
----------------
D
F
R
K
E
L
-
E
E
S
-
S
P
I
-
F
---
E
R
P
T
G
E
V
S
T
K
N
E
D
--
I
C
L
V
Y
-
F
S
S
G
T
A
G
F
P
K
M
V
E
H
--
D
N
T
Y
-
P
L
G
H
-
I
--
L
T
A
K
----
Y
--
W
Q
N
-------
V
E
-------
D
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
-
W
G
KLY
G
Q
W
I
A
G
C
----
A
V
F
V
Y
----
D
Y
D
--
R
F
E
---
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
F
L
I
K
E
D
L-----
N
F
S
---
T
L
----
K
-
Y
A
V
-----
V
A
--
G
E
P
L
N
P
E
V
F
N
R
F
L
E
-
F
----
T
--
G
I
K
--
L
M
E
G
F
G
Q
T
E
T
V
-----
V
T
I
A
T
F
P
WME
P
-----
K
--
P
G
S
I
G
K
P
T
P
G
Y
K
I
----------------
E
L
M
-------
D
R
D
G
R
L
C
---
E
V
G
E
E
G
E
I
-
V
I
N
T
M
---
E
---
G
K
P
VGL
F
V
--
H
Y
G
K
D
P
E
R
T
E
E
T
W
-------
H
D
G
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
------
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
----
G
Q
V
I
K
A
T
I
V
L
T
KD
Y
T
P
S
D
-----
S
L
K
N
E
----
L
Q
D
H
V
K
----
N
V
-----
T
A
P
Y
K
-
Y
P
R
I
I
E
F
V
P
E
--------------------------------------------------------
31
HHSearch
88.94
20%
-102
- C2 -
3ETC
10
?
A:
[26-559]
---------------------------------
S
L
L
S
Q
F
V
S
K
T
D
F
E
S
Y
E
D
F
Q
E
N
F
K
I
L
V
--------
P
E
N
F
N
F
A
Y
D
V
V
D
V
Y
A
-----
R
D
S
P
E
K
L
A
M
I
W
C
D
DYG
N
E
-----
K
------
I
F
--
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
-
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
------
I
A
--
E
D
D
V
P
E
Q
V
-
D
E
A
----
H
A
E
C
G
----
D
I
P
L
K
K
A
K
-
V
----
G
G
D
V
L
E
G
W
I
----------------
D
F
R
K
E
L
-
E
E
S
-
S
P
I
-
F
---
E
R
P
T
G
E
V
S
T
K
N
E
D
--
I
C
L
V
Y
-
F
S
S
G
T
A
G
F
P
K
M
V
E
H
--
D
N
T
Y
P
L
G
H
I
-
L
--
T
A
K
Y
----
W
--
Q
N
V
-------
E
D
-------
D
G
L
H
Y
T
V
A
D
S
G
W
G
K
C
V
W
-
G
K
------
L
Y
G
Q
W
I
A
G
C
A
V
F
V
----
Y
-
D
YD
R
F
E
---
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
F
L
I
K
E
D
-
L
------
N
---
F
S
----
T
-
L
K
Y
-----
A
V
V
A
G
E
P
L
N
P
E
V
F
N
R
F
L
E
F
T
----
G
--
I
-
K
--
L
M
E
G
F
G
Q
T
E
T
V
-----
V
T
I
A
T
F
P
---
W
-----
M
-----
E
P
K
P
G
S
I
G
K
P
T
P
-
G
-
Y
K
I
E
L
M
D
R
D
G
R
------------------
L
C
E
V
G
E
E
G
-
E
I
V
I
N
T
M
---
E
GKP
V
G
L
---
F
V
--
H
Y
G
K
D
P
E
R
T
E
E
T
W
-------
H
D
G
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
-
A
V
L
E
C
A
I
T
G
V
P
D
P
V
-----
R
----
G
Q
V
I
K
A
T
I
V
L
----
T
K
D
Y
T
P
S
--
D
S
L
K
N
---
E
L
Q
D
H
V
K
----
N
V
-----
T
A
P
Y
K
-
Y
P
R
I
I
E
F
V
P
E
--------------------------------------------------------
42
HHSearch
88.15
19%
-93
- C2 -
3NI2
4
?
A:
[19-532]
--------------------------------------------------------------------
P
K
N
L
P
L
H
S
Y
V
L
E
N
L
-----
S
N
H
S
S
K
P
C
L
I
N
G
AN---
G
-----
D
------
V
Y
--
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
-
K
I
-
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
------
Q
A
--
C
Y
Y
--
E
K
V
-
K
D
F
----
A
R
E
S
-----
D
V
K
V
M
C
V
--
D
----
S
A
--
P
D
G
C
L
----------------
H
F
S
E
L
T
-
Q
A
D
-
E
N
E
-
A
-------
P
Q
V
D
I
S
P
D
D
--
V
V
A
L
P
-
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
--
T
H
K
G
L
I
T
S
V
-
A
--
Q
Q
V
D
GDNP
N
--
L
Y
F
-------
H
S
-------
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
N
-
S
I
------
M
L
C
G
L
R
V
G
A
P
I
L
I
----
M
-
P
--
K
F
E
---
I
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
V
M
M
S
I
A
K
S
P
-
D
L
--
D
K
H
D
---
L
S
----
S
-
L
R
M
-----
I
K
S
G
G
A
P
L
G
K
E
L
E
D
T
V
R
A
K
F
----
P
--
Q
A
R
--
L
G
Q
G
Y
G
M
T
E
A
G
-----
P
V
L
A
M
C
L
---
A
-----
F
AK
E
P
F
D
I
K
P
G
A
C
G
T
V
V
R
-
N
-
A
E
M
K
I
V
D
P
E
T
G
-----------------
A
S
L
P
R
N
Q
P
G
-
E
I
C
I
R
G
D
--------
Q
I
---
M
K
--
G
Y
L
N
D
P
E
A
T
S
R
T
I
------
D
K
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
-
E
I
S
D
A
A
V
V
G
L
K
D
E
D
-----
A
----
G
E
V
P
V
A
F
V
V
K
----
S
E
K
S
-----
Q
A
T
E
D
---
E
I
K
Q
Y
I
S
----
K
Q
-----
V
I
F
Y
K
-
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
---------------------------------------
50
HHSearch
87.23
22%
-101
- C2 -
1T5H
-
?
X:
[2-503]
-----------------------------------------------------------------------
Q
T
V
N
E
M
L
R
R
A
A
-----
T
R
A
P
D
H
C
A
L
A
V
P
AR---
G
-----
L
------
R
L
--
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
-
A
D
-
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
I
------
A
V
----
Q
VA
D
A
I
-
F
Q
S
----
G
S
-------
G
A
R
I
I
F
L
--
G
----
D
L
----------------------------
V
-
R
D
G
E
P
Y
S
-
Y
---
G
P
P
I
E
D
P
Q
R
E
P
A
Q
--
P
A
F
I
F
-
Y
T
S
---
G
L
P
K
A
A
I
I
--
P
Q
R
A
A
E
S
R
V
-
L
--
F
M
S
T
----
Q
--
V
G
L
RH-----
G
R
-------
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
-
A
V
------
L
V
A
A
L
A
L
D
G
T
Y
V
V
----
V
-
E
--
E
F
R
---
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
-
A
H
AG
S
S
L
K
---
L
D
----
S
-
L
R
H
-----
V
T
FA
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
----
P
--
G
-
E
--
K
V
N
I
Y
G
T
T
E
A
M
-----
N
S
L
Y
M
R
Q
---
P
-----
K
--
T
G
T
E
M
A
P
------
G
F
-
F
-
S
E
V
R
I
V
R
I
G
G
---------------
G
V
D
E
I
V
A
N
G
E
E
G
-
E
L
I
V
A
A
S
---
D
----
S
A
---
F
V
--
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-------
Q
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
-
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
-----
W
----
G
Q
S
V
T
A
C
V
V
P
----
R
L
G
E
-----
T
L
S
A
D
---
A
L
D
T
F
C
R
S---
S
E
-----
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-------------------------------------
38
HHSearch
87.08
19%
-101
- C2 -
3C5E
4
ACS2A_HUMAN
A:
[37-562]
----------------------------------------------------------------------
F
N
F
A
S
D
V
L
D
H
W
A
D
M
E
K
A
G
K
R
P
P
S
P
A
L
W
W
V
-----
N
GKG
K
E
L
------
M
W
--
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
-
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
------
G
D
--
E
V
I
--
Q
E
V
-
D
T
V
----
A
S
E
C
P
-
S
L-
R
I
K
L
L
-
V
--
S
----
E
K
S
-
C
D
G
W
L
----------------
N
F
K
K
L
L
-
N
E
A
-
S
T
T
-
H
---
H
----
C
V
E
T
G
S
Q
E
--
A
S
A
I
Y
-
F
T
S
G
T
S
G
L
P
K
M
A
E
H
--
S
Y
S
S
L
G
L
K
A
-
K
--
M
D
A
G
----
W
--
T
G
L
-------
Q
A
-------
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
L
-
C
S
------
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L--
L
-
P
--
K
F
D
---
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
L
Q
Q
D
-
L
S
--
S
-
Y
K
---
F
P
----
H
-
L
Q
N
-----
C
V
T
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
----
G
--
L
-
D
--
I
R
E
S
Y
G
Q
T
E
T
G
-----
L
T
C
M
V
S
K
---
T
-----
M
-----
K
I
K
P
G
Y
M
G
T
A
A
S
-
C
-
Y
D
V
Q
I
I
D
D
K
G
------------------
N
V
L
P
P
G
T
E
G
-
D
I
G
I
R
V
K
P
I
R
P
---
I
G
I
---
F
S
--
G
Y
V
D
N
P
D
K
T
A
A
N
I
-------
R
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
-
A
V
V
E
T
A
V
I
S
S
P
D
P
V
-----
R
----
G
E
V
V
K
A
F
V
V
L
----
A
S
Q
F
LSHD
P
E
Q
L
T
K
---
E
L
Q
Q
H
V
K
----
S
V
-----
T
A
P
Y
K
-
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
------------------------------------
7
PsiBlast_PDB
87.03
21%
-101
- C2 -
1ULT
1
LCFCS_THET8
A:
[40-532]
------------------------------------------------------------------------------------------------
L
H
T
-----
G
-----
E
------
V
H
R
T
T
Y
A
E
V
Y
Q
R
A
R
R
L
M
G
-
G
L
-
R
A
L
G
V
G
V
G
D
R
V
A
T
L
G
F
N
H
F
R
H
L
E
A
Y
F
A
V
P
G
M
G
A
V
L
H
T
A
N
P
R
L
S
P
K
E
I
A
Y
I
L
N
H
A
E
D
K
V
L
L
F
------
D
P
--
N
L
L
--
P
L
V
-
E
A
I
----
R
G
E
L
K
-
T
--
V
Q
H
F
V
-
V
--
M
----
D
E
K
A
P
E
G
Y
L
----------------
A
Y
E
E
A
L
-
G
E
E
-
A
D
P
V
R
---
V
P
E
--------
R
A
--
A
C
G
M
A
-
Y
T
T
G
T
T
G
L
P
K
G
V
V
Y
--
S
H
R
A
-
L
V
L
H
-
S
--
L
A
A
S
----
L
--
V
D
G
-------
T
A
LSE----
K
D
V
V
L
P
V
V
P
M
F
H
V
N
A
W
C
-
L
P
------
Y
A
A
T
L
-
V
G
A
K
Q
V
L
----
P
G
P
--
R
L
D
---
P
A
S
L
V
E
L
F
D
G
E
G
V
T
F
T
A
G
V
P
T
V
W
L
A
L
A
D
Y
L
-
E
S
--
T
G
H
R
---
L
K
----
T
-
L
R
R
-----
L
V
--
V
G
G
--
S
A
A
P
R
S
L
I
A
R
F
----
E
R
M
G
V
E
--
V
R
Q
G
Y
G
L
T
E
T
S
P----
V
V
V
Q
N
F
V
-----------------
K
S
H
L
--
E
S
L
S
-
E
-
E
E
K
L
T
L
K
A
K
T
G
L
P
I
PL
V
R
L
R
V
A
D
E
E
G
R
P
V
P
----
K
D
G
K
A
-
L
G
E
V
Q
---
L
---
K
G
P
---
W
I
TG
G
Y
Y
G
N
E
E
A
T
R
S
A
L
T
P
D
G
F
------
F
R
T
G
D
I
A
V
W
D
E
E
G
Y
V
E
I
K
D
R
L
K
D
L
I
K
S
G
G
E
W
I
S
S
V
D
L
E
N
A
L
M
G
-
H
P
K
V
K
E
A
A
V
V
A
I
P
H
P
K
----
W
Q
----
E
R
P
--
L
A
V
V
V
----
P
R
G
E
-----
K
P
T
P
E
---
E
L
N
E
H
L
L
K
---
A
G
-----
F
A
K
W
Q
-
L
P
D
A
Y
V
F
A
E
E
I
P
R
T
S
A
G
K
F
L
K
R
A
L
R
E
Q
Y
K
N
Y
Y
G
G
--------------------------------
22
Fugue
85.43
17%
-94
- C2 -
1PG4
5
ACSA_SALTY
A:
[5-647]
H
K
H
A
I
P
A
N
I
A
D
R
C
L
I
N
P
E
Q
Y
E
T
K
Y
K
Q
S
I
N
D
P
D
T
F
W
G
E
Q
G
K
I
L
D
W
I
T
P
Y
Q
K
V
K
N
T
S
FAPG
N
V
S
I
K
W
YE
D
G
T
L
N
L
A
A
N
C
L
D
R
H
L
-----
Q
E
N
G
D
R
T
A
I
I
W
E
-----
G
-----
D
DTS
Q
S
K
H
I
--
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
-
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
D----
E
G
--
V
R
A
--
G
R
S
-
I
P
L
----
K
K
N
V
D
-
D
--
A
L
K
N
P
-
N
--
V
----
T
-
S
V
E
H
V
I
V
L
KRTG
S
D
I
D
W
Q
E
GRDL
W
W
R
D
L
I
-
E
K
A
-
S
P
E
-
H
---
Q
P
E
A
M
N
A
----
E
D
--
P
L
F
I
L
-
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
Y
L
-
V
Y
A
A
-
T
--
T
F
K
Y
----
V
--
F
D
Y
-------
H
P
-------
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
-
Y
L
------
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
EGV
P
-
N
--
W
P
T
---
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
A
E
G
-
D
K
--
A
I
E
G
---
T
D
RSSL
R
-
I
L
G
-----
S
V
--
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
----
G
--
K
E
K
C
P
V
V
D
T
W
W
Q
T
E
T
G
-----
G
F
M
I
T
P
L
---
P
-----
G
--
A
I
E
L
K
A
G
S
A
T
R
P
F
F
G
V
Q
-
P
A
L
V
------------------
D
N
E
G
--
H
P
Q
E
G
A
T
E
G
N
L
-
V
I
----------
T
D
S
---
W
P
--
G
Q
A
R
T
L
F
G
D
H
E
R
F
E
Q
T
Y
F
S
T
F
K
N
M
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
-
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
-----
I
K
----
G
Q
A
I
Y
A
Y
V
T
L
----
N
H
G
E
-----
E
P
S
P
E
L
Y
A
E
V
R
N
W
V
R
----
K
E
-----
I
G
P
L
A
-
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
G
D
A
D
P
G
V
V
E
K
L
L
E
E
K
Q
A
--------------------
41
HHSearch
85.18
19%
-91
- C2 -
1MDB
2
DHBE_BACSU
A:
[24-533]
----------------------------------------------------------------------
G
E
T
F
G
D
L
L
R
D
R
A
-----
A
K
Y
G
D
R
I
A
I
T
C
G
-----
N
-----
T
------
H
W
--
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
-
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
------
P
D
--
A
Y
S
--
G
F
D
Y
R
S
L
A
R
Q
V
Q
S
K
L
P
-
T
LK
N
I
I
V
--
A
--
G
----
E
A
E
---
E
F
L
----------------
P
----
L
-
E
D
L
-
H
T
E
-
P
---
V
---
K
L
P
E
V
K
S
S
D
--
V
A
F
L
Q
-
L
S
G
G
S
T
G
L
S
K
L
I
P
R
--
T
H
D
D
Y
I
Y
S
L
-
K
--
R
S
V
E
----
V
--
C
W
L
-------
D
H
-------
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
S
P
G
------
V
L
G
V
L
Y
A
G
G
R
V
V
L
----
S
-
P
--
S
P
S
---
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
A
-
S
S
--
R
R
D
D
---
L
S
----
S
-
L
Q
V
-----
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
----
G
--
C
-
T
--
L
Q
Q
V
F
G
M
A
E
G
L
-----
V
N
Y
T
R
L
D
---
D
--------
P
-
E
E
I
I
V
N
T
Q
G
K
P
M
S
-
P
Y
D
E
S
R
V
W
D
D
H
D
------------------
R
D
V
K
P
G
E
T
G
-
H
L
L
T
R
G
P
--------
Y
T
---
I
R
--
G
Y
Y
K
A
E
E
H
N
A
A
S
F
T
------
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
-
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
-----
L
----
G
E
R
S
C
V
F
I
I
P
----
R
D
E
------
A
P
K
A
A
---
E
L
K
A
F
L
R
----
E
R
G----
L
A
A
Y
K
-
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
L
L
A
G
-------------------------------
1
PsiBlast_PDB
84.16
24%
-87
- C2 -
3R44
1
FAC13_MYCTU
A:
[45-509]
-------------------------------------------------------------------------------------------------------------------------
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
-
L
-
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
------
G
A
--
P
S
A
--
P
V
I
-
D
A
I
----
R
A
Q
A
D
-
P
PG
T
V
T
D
W
--------------
I
G
A
D
----------------
S
L
A
E
R
L
R
S
A
A
-
A
D
E
-
P
---------
A
V
E
C
G
G
D
--
D
N
L
F
I
M
Y
T
S
---
G
H
P
K
-
G
V
V
--
H
T
H
E
-
S
V
H
S
-
A
--
A
S
S
W
----
A
S
T
I
D
V
-------
R
Y
-------
R
D
R
L
L
L
P
L
P
M
F
H
V
A
A
L
T
-
T
V
------
I
F
S
A
M
R
-
G
V
T
L
I
S
----
M
-
P
--
Q
F
D
---
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
-
R
Q
V
-
P
E
--
F
A
E
L
---
D
A
----
P
D
F
R
Y
-----
F
I
--
T
G
G
A
P
M
P
E
A
L
I
K
I
Y
A
A
----
K
--
N
I
E
--
V
V
Q
G
Y
A
L
T
E
S
C
GGGTL
L
L
S
E
D
A
L
---
R
-----
K
--
A
G
S
A
G
R
A
T
M
F
-----------------
T
D
V
A
V
-------
R
G
D
D
G
--
V
I
R
E
H
G
E
G
E
V
V
-
I
K
S
D
I
---
L
---
L
K
E
---
Y
W
----------
N
R
P
E
A
T
R
D
A
F
D
N
G
--
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
-
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
----
W
G
----
E
I
A
--
A
A
I
V
V
----
A
D
Q
N
-----
E
V
S
E
Q
---
Q
I
V
E
Y
C
G
----
T
R
-----
L
A
R
Y
K
-
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
A
T
V
P
---------------------------------
3
PsiBlast_PDB
83.69
22%
-104
- C2 -
3IVR
5
?
A:
[7-397]
------------------------------------------------------------------------
T
L
A
D
V
Y
R
R
N
A
-----
A
L
F
P
D
R
T
A
F
M
V
D
-----
G
-----
V
------
R
L
--
T
H
R
D
Y
L
A
R
A
E
R
L
A
S
G
L
L
--
R
D
G
V
H
T
G
D
R
V
A
I
L
S
Q
N
C
S
E
M
I
E
L
I
G
A
V
A
L
I
G
A
I
L
L
P
V
N
Y
R
L
N
A
D
E
I
A
F
V
L
G
D
G
A
P
S
V
V
V
A
------
G
T
--
D
Y
R
--
D
I
V
-
A
G
V
----
L
P
S
L
G
-
G
--
V
K
K
A
Y
-
A
--
I
----
G
D
G
--
S
G
P
F
----------------
A
P
F
K
D
L
-
A
S
---
D
T
-
P
---
F
S
A
P
E
F
G
A
A
---
D
--
G
F
V
I
I
-
H
T
A
A
--
G
R
P
R
G
A
L
I
--
S
Q
G
N
-
L
L
I
A
Q
S
--
S
L
V
D
----
A
--
W
R
L
-------
T
E
-------
A
D
V
N
L
G
M
L
P
L
F
H
V
T
G
L
G
-
L
M
------
L
T
-
L
Q
Q
A
G
G
A
S
V
I
----
A
-
A
--
K
F
D
---
P
A
Q
A
A
R
D
I
E
A
H
K
V
T
V
M
A
E
F
A
P
M
L
G
N
I
L
D
Q
A
-
A
----------------
P
-
A
Q
L
-----
A
S
--
L
R
A
V
T
G
L
D
T
P
E
T
I
E
R
F
E
A
T
C
P
--
N
A
T
--
F
W
A
T
F
G
Q
S
E
T
S
GL---
S
T
F
A
P
Y
R
---
D
-----
R
--
P
K
S
A
G
R
P
-
L
F
W
R
T
V
A
-
V
-
V
D
------
A
E
D
R
P
L
-----------------
P
P
G
E
V
G
E
I
-
V
L
R
-----
G
---
P
T
V
---
F
K
--
G
Y
W
N
N
A
A
A
T
Q
-----
H
A
F
R
N
G
--
W
H
H
T
G
D
M
G
R
F
D
A
D
G
Y
L
F
Y
A
G
R
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.65
22%
-97
- C2 -
1T5D
1
?
X:
[31-500]
-------------------------------------------------------------------------------------------------------------------------
T
H
A
E
L
R
A
R
V
E
A
V
A
-
A
R
L
-
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
I
------
A
V
--
G
R
Q
---
V
A
-
D
A
I
----
F
Q
S
G
S
G
A
--
R
I
I
F
L
-
G
DL
V
----
R
D
G
E
P
Y
S
Y
G
----------------
P
P
I
E
D
P
-
Q
R
E
-
P
A
Q
-
P
-------------------
A
F
I
F
-
Y
T
S
--
T
G
L
P
K
A
A
I
I
--
P
Q
-----
R
A
-
A
--
E
S
R
V
----
L
--
F
M
S
-------
T
Q
VGLRHGR
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
-
A
V
------
L
V
A
A
L
A
L
D
G
T
Y
V
V
----
V
-
E
--
E
F
R
---
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
-
A
H
--
A
G
S
S
LKL
D
S
----
L
-
R
H
V
-----
T
F
--
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
----
L
--
P
G
E
--
K
V
N
I
Y
G
T
T
E
A
M
-----
N
S
L
Y
M
R
Q
---
P
-----
K
--
T
G
----
T
E
M
A
P
G
F
F
S
-
E
-
V
R
I
V
R
I
G
G
G
V
D
E
I
V
-------
A
N
----------
G
E
E
G
E
L
-
I
V
-
A
A
---
S
---
D
S
A
---
F
V
--
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
-------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
-
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
----
W
-----
G
Q
S
V
T
A
C
V
V
P
----
R
L
G
E
-----
T
L
S
A
D
---
A
L
D
--------
T
F
CRSSE
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
S
------------------------------------
17
PsiBlast_PDB
83.32
22%
-99
- C2 -
1T5H
-
?
X:
[31-500]
-------------------------------------------------------------------------------------------------------------------------
T
H
A
E
L
R
A
R
V
E
A
V
A
-
A
R
L
-
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
I
------
A
V
----
Q
---
V
A
-
D
A
I
----
F
Q
S
G
S
G
A
--
R
I
I
F
L
-
G
DL
V
----
R
D
G
E
P
Y
S
Y
G
----------------
P
P
I
E
D
P
-
Q
R
E
-
P
A
Q
-
P
-------------------
A
F
I
F
-
Y
T
S
---
G
L
P
K
A
A
I
I
--
P
Q
-----
R
A
-
A
--
E
S
R
V
----
L
--
F
M
S
-------
T
Q
VGLRHGR
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
-
A
V
------
L
V
A
A
L
A
L
D
G
T
Y
V
V
----
V
-
E
--
E
F
R
---
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
-
A
H
--
A
G
S
S
LKL
D
S
----
L
-
R
H
V
-----
T
F
--
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
----
L
--
P
G
E
--
K
V
N
I
Y
G
T
T
E
A
M
-----
N
S
L
Y
M
R
Q
---
P
-----
K
--
T
G
----
T
E
M
A
P
G
F
F
S
-
E
-
V
R
I
V
R
I
G
G
G
V
D
E
I
V
-------
A
N
----------
G
E
E
G
E
L
-
I
V
-
A
A
---
S
---
D
S
A
---
F
V
--
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
-------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
-
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
----
W
-----
G
Q
S
V
T
A
C
V
V
P
----
R
L
G
E
-----
T
L
S
A
D
---
A
L
D
--------
T
F
CRSSE
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-------------------------------------
14
PsiBlast_PDB
83.10
22%
-94
- C2 -
3CW9
3
?
A:
[31-500]
-------------------------------------------------------------------------------------------------------------------------
T
H
A
E
L
R
A
R
V
E
A
V
A
-
A
R
L
-
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
I
------
A
V
--
G
R
Q
---
V
A
-
D
A
I
----
F
Q
S
G
S
G
A
--
R
I
I
F
L
-
G
DL
V
----
R
D
G
E
P
Y
S
Y
G
----------------
P
P
I
E
D
P
-
Q
R
E
-
P
A
Q
-
P
-------------------
A
F
I
F
-
Y
T
S
G
T
T
G
L
P
K
A
A
I
I
--
P
Q
-----
R
A
-
A
--
E
S
R
V
----
L
--
F
M
S
-------
T
Q
VGLRHGR
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
-
A
V
------
L
V
A
A
L
A
L
D
G
T
Y
V
V
----
V
-
E
--
E
F
R
---
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
-
A
H
--
A
G
S
S
LKL
D
S
----
L
-
R
H
V
-----
T
F
--
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
----
L
--
P
G
E
--
K
V
N
I
Y
G
T
T
E
A
M
-----
N
S
L
Y
M
R
Q
---
P
-----
K
--
T
G
----
T
E
M
A
P
G
F
F
S
-
E
-
V
R
I
V
R
I
G
G
G
V
D
E
I
V
-------
A
N
----------
G
E
E
G
E
L
-
I
V
-
A
A
---
S
---
D
S
A
---
F
V
--
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
-------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
-
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
----
W
-----
G
Q
S
V
T
A
C
V
V
P
----
R
L
G
E
-----
T
L
S
A
D
---
A
L
D
--------
T
F
C
R
S
SE
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-------------------------------------
20
PsiBlast_PDB
82.98
22%
-94
- C2 -
2QVX
1
?
X:
[31-500]
-------------------------------------------------------------------------------------------------------------------------
T
H
A
E
L
R
A
R
V
E
A
V
A
-
A
R
L
-
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
I
------
A
V
--
G
R
Q
---
V
A
-
D
A
I
----
F
Q
S
G
S
G
A
--
R
I
I
F
L
-
G
DL
V
----
R
D
G
E
P
Y
S
Y
G
----------------
P
P
I
E
D
P
-
Q
R
E
-
P
A
Q
-
P
-------------------
A
F
I
F
-
Y
T
S
--
T
G
L
P
K
A
A
I
I
--
P
Q
-----
R
A
-
A
--
E
S
R
V
----
L
--
F
M
S
-------
T
Q
VGLRHGR
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
-
A
V
------
L
V
A
A
L
A
L
D
G
T
Y
V
V
----
V
-
E
--
E
F
R
---
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
-
A
H
--
A
G
S
S
LKL
D
S
----
L
-
R
H
V
-----
T
F
--
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
----
L
--
P
G
E
--
K
V
N
G
Y
G
T
T
E
A
M
-----
N
S
L
Y
M
R
Q
---
P
-----
K
--
T
G
----
T
E
M
A
P
G
F
F
S
-
E
-
V
R
I
V
R
I
G
G
G
V
D
E
I
V
-------
A
N
----------
G
E
E
G
E
L
-
I
V
-
A
A
---
S
---
D
S
A
---
F
V
--
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
-------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
-
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
----
W
-----
G
Q
S
V
T
A
C
V
V
P
----
R
L
G
E
-----
T
L
S
A
D
---
A
L
D
--------
T
F
CRSSE
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
--------------------------------------
15
PsiBlast_PDB
82.97
22%
-95
- C2 -
3DLP
1
?
X:
[31-500]
-------------------------------------------------------------------------------------------------------------------------
T
H
A
E
L
R
A
R
V
E
A
V
A
-
A
R
L
-
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
I
------
A
V
--
G
R
Q
---
V
A
-
D
A
I
----
F
Q
S
G
S
G
A
--
R
I
I
F
L
-
G
DL
V
----
R
D
G
E
P
Y
S
Y
G
----------------
P
P
I
E
D
P
-
Q
R
E
-
P
A
Q
-
P
-------------------
A
F
I
F
-
Y
T
S
G
T
T
G
L
P
K
A
A
I
I
--
P
Q
-----
R
A
-
A
--
E
S
R
V
----
L
--
F
M
S
-------
T
Q
VGLRHGR
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
-
A
V
------
L
V
A
A
L
A
L
D
G
T
Y
V
V
----
V
-
E
--
E
F
R
---
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
-
A
H
--
A
G
S
S
LKL
D
S
----
L
-
R
H
V
-----
T
F
--
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
----
L
--
P
G
E
--
K
V
N
I
Y
G
T
T
E
A
M
-----
N
S
L
Y
M
R
Q
---
P
-----
K
--
T
G
----
T
E
M
A
P
G
F
F
S
-
E
-
V
R
I
V
R
I
G
G
G
V
D
E
I
V
-------
A
N
----------
G
E
E
G
E
L
-
I
V
-
A
A
---
S
---
D
S
A
---
F
V
--
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
-------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
P
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
-
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
----
W
-----
G
Q
S
V
T
A
C
V
V
P
----
R
L
G
E
-----
T
L
S
A
D
---
A
L
D
--------
T
F
CRSSE
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
S
------------------------------------
4
PsiBlast_PDB
82.73
23%
-94
- C2 -
5BUR
3
?
A:
[11-479]
-----------------------------------------------------------------------------
L
M
Q
R
A
-----
Q
L
T
P
E
R
I
A
L
I
Y
E
-----
D
-----
Q
------
T
V
--
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
-
A
H
S
-
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
------
D
S
--
S
F
E
--
K
K
E
-
Y
E
H
----
I
V
Q
---------------------------
T
I
----------------
D
V
D
E
L
M
-
K
E
A
-
A
E
E
-
I
---
E
I
E
A
Y
M
Q
---
M
D
A
--
T
A
T
L
M
-
Y
T
S
G
T
T
G
K
P
K
-
G
V
Q
--
Q
T
F
G
-
N
H
Y
F
-
S
--
A
V
S
S
----
A
L
N
L
G
I
-------
T
E
-------
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
-
G
L
-
S
A
------
L
F
K
S
V
I
Y
G
M
T
V
V
L
----
H
-
Q
--
R
F
S
---
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
-
N
R
--
C
P
E
S
---
I
R
----
C
-
I
L
L
-----
G
---
G
G
P
A
P
L
P
L
L
E
E
C
R
E
K
--------
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
-----
S
Q
I
V
T
L
S
---
P
EFSME
K
--
L
G
S
A
G
K
-----
P
L
F
S
-
C
-
E
I
K
I
E
R
D
G
Q
V
C
E
P
Y
-------
E
H
----------
G
E
--
I
M
-
V
K
G
P
N
---
V
---
M
K
S
---
Y
F
--
N
R
E
S
A
N
E
A
S
--------
F
Q
N
G
--
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
-
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
-----------
G
K
V
P
H
A
Y
L
V
L
H---
K
P
V
S
-----
A
G
E
L
T
---
D
Y
C
K
E
R
------------
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
----------------------------------------
36
HHSearch
82.71
18%
-91
* C2 *
2D1S
1
LUCI_LUCCR
A:
[19-544]
-------------------------------------------------------------------
P
I
E
E
G
S
A
G
T
Q
L
R
K
Y
M
-----
E
R
Y
A
K
L
G
A
I
A
F
T
NAVT-
G
-----
V
------
D
Y
--
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
-
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
------
S
K
--
K
G
L
--
D
K
V
-
I
T
V
----
Q
K
T
V
T
-
T
I-
K
T
I
V
I
-
L
--
D
----
S
K
V
D
Y
R
G
Y
Q
----------------
C
L
D
T
F
I
-
K
R
N
-
T
P
P
-
G
FQA
S
S
F
K
T
V
E
V
D
R
K
E
Q
--
V
A
L
I
M
-
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
--
T
H
E
N
I
V
T
R
F
-
S
--
H
A
R
D
PIY-
G
--
N
Q
V
-------
S
P
-------
G
T
A
V
L
T
V
V
P
F
H
H
G
F
G
M
F
--
T
------
T
L
G
Y
L
I
C
G
F
R
V
V
M
----
L
-
T
--
K
F
D
---
E
E
T
F
L
K
T
L
Q
D
Y
K
C
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
E
-
L
L
--
N
K
Y
D
---
L
S
----
N
-
L
V
E
-----
I
A
S
G
G
A
P
L
S
K
E
V
G
E
A
V
A
R
R
F
----
N
--
L
P
G
--
V
R
Q
G
Y
G
L
T
E
T
T
-----
S
A
I
I
I
T
P
---
E
-----
G
-----
D
D
K
P
G
A
S
G
K
V
V
P
-
L
-
F
K
A
K
V
I
D
L
D
T
K
-----------------
K
S
L
G
P
N
R
R
G
-
E
V
C
V
K
G
P
--------
M
L
---
M
K
--
G
Y
V
N
N
P
E
A
T
K
E
L
I
------
D
E
E
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
P
-
S
I
F
D
A
G
V
A
G
V
P
D
P
V
-----
A
----
G
E
L
P
G
A
V
V
V
L
----
E
S
G
K
-----
N
M
T
E
K
---
E
V
M
D
Y
V
A
----
S
Q
-----
V
S
N
A
K
R
L
R
G
G
V
R
F
V
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
I
L
K
K
P
V
----------------------------------
5
PsiBlast_PDB
82.69
23%
-95
- C2 -
5BUS
1
?
A:
[11-479]
-----------------------------------------------------------------------------
L
M
Q
R
A
-----
Q
L
T
P
E
R
I
A
L
I
Y
E
-----
D
-----
Q
------
T
V
--
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
-
A
H
S
-
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
------
D
S
--
S
F
E
--
K
K
E
-
Y
E
H
----
I
V
Q
---------------------------
T
I
----------------
D
V
D
E
L
M
-
K
E
A
-
A
E
E
-
I
---
E
I
E
A
Y
M
Q
---
M
D
A
--
T
A
T
L
M
-
Y
T
S
G
T
T
G
K
P
K
-
G
V
Q
--
Q
T
F
G
-
N
H
Y
F
-
S
--
A
V
S
S
----
A
L
N
L
G
I
-------
T
E
-------
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
-
G
L
-
S
A
------
L
F
K
S
V
I
Y
G
M
T
V
V
L
----
H
-
Q
--
R
F
S
---
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
-
N
R
--
C
P
E
S
---
I
R
----
C
-
I
L
L
-----
G
---
G
G
P
A
P
L
P
L
L
E
E
C
R
E
K
--------
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
-----
S
Q
I
V
T
L
S
---
P
EFSME
K
--
L
G
S
A
G
K
-----
P
L
F
S
-
C
-
E
I
K
I
E
R
D
G
Q
V
C
E
P
Y
-------
E
H
----------
G
E
--
I
M
-
V
K
G
P
N
---
V
---
M
K
S
---
Y
F
--
N
R
E
S
A
N
E
A
S
--------
F
Q
N
G
--
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
-
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
K
-----------
K
V
P
H
A
Y
L
V
L
H---
K
P
V
S
-----
A
G
E
L
T
---
D
Y
C
K
E
R
------------
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
A
R
K
G
E
L
----------------------------------
16
PsiBlast_PDB
82.68
22%
-94
- C2 -
3CW8
4
?
X:
[31-500]
-------------------------------------------------------------------------------------------------------------------------
T
H
A
E
L
R
A
R
V
E
A
V
A
-
A
R
L
-
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
G
E
M
T
A
A
V
I
------
A
V
--
G
R
Q
---
V
A
-
D
A
I
----
F
Q
S
G
S
G
A
--
R
I
I
F
L
-
G
DL
V
----
R
D
G
E
P
Y
S
Y
G
----------------
P
P
I
E
D
P
-
Q
R
E
-
P
A
Q
-
P
-------------------
A
F
I
F
-
Y
T
S
G
T
T
G
L
P
K
A
A
I
I
--
P
Q
-----
R
A
-
A
--
E
S
R
V
----
L
--
F
M
S
-------
T
Q
VGLRHGR
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
-
A
V
------
L
V
A
A
L
A
L
D
G
T
Y
V
V
----
I
-
E
--
E
F
R
---
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
-
A
H
--
A
G
S
S
LKL
D
S
----
L
-
R
H
V
-----
T
F
--
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
----
L
--
P
G
E
--
K
V
N
I
Y
G
T
T
E
A
M
-----
N
S
L
Y
M
R
Q
---
P
-----
K
--
T
G
----
T
E
M
A
P
G
F
F
S
-
E
-
V
R
I
V
R
I
G
G
G
V
D
E
I
V
-------
A
N
----------
G
E
E
G
E
L
-
I
V
-
A
A
---
S
---
D
S
A
---
F
V
--
G
Y
L
N
Q
P
E
A
T
A
E
K
L
Q
-------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
-
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
-----
W
-----
G
Q
S
V
T
A
C
V
V
P
----
R
L
G
E
-----
T
L
S
A
D
---
A
L
D
--------
T
F
CRSSE
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
--------------------------------------