@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S39A5_HUMAN: (2015-12-10 )
MMGSPVSHLLAGFCVWVVLGWVGGSVPNLGPAEQEQNHYLAQLFGLYGENGTLTAGGLARLLHSLGLGRVQGLRLGQHGPLTGRAASPAADNSTHRPQNPELSVDVWAGMPLGPSGWGDLEESKAPHLPRGPAPSGLDLLHRLLLLDHSLADHLNEDCLNGSQLLVNFGLSPAAPLTPRQFALLCPALLYQIDSRVCIGAPAPAPPGDLLSALLQSALAVLLLSLPSPLSLLLLRLLGPRLLRPLLGFLGALAVGTLCGDALLHLLPHAQEGRHAGPGGLPEKDLGPGLSVLGGLFLLFVLENMLGLLRHRGLRPRCCRRKRRNLETRNLDPENGSGMALQPLQAAPEPGAQGQREKNSQHPPALAPPGHQGHSHGHQGGTDITWMVLLGDGLHNLTDGLAIGAAFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQSGLSFRRLLLLSLVSGALGLGGAVLGVGLSLGPVPLTPWVFGVTAGVFLYVALVDMLPALLRPPEPLPTPHVLLQGLGLLLGGGLMLAITLLEERLLPVTTEG
Atome Classification :
(20 SA)
----------------.........10.......------.20....-------....30.......----------.40......----.----.--50......---------..60.--------------.-......70...----------------.....80.-.......90-.......------------..100..-.....110.-....------..120.......-----------130.......140-----........--------150....-...160....---...---------170.......180.......-----------------------.190.......200..---------------.....------210....--...220..--.....-----------230-------.....-------..240..------.....---250...--------....260---..---.....-.270....-...280...-....290-----.........------------300--------------.....-..310---...--------------.--------.--------------------.-----..320.......330----..-......340--------.......350....---.-----..360.----------......370.......380....---....390.....----..400.---.......410.......420---------........430--.......-----..440..---------.....450---------.......460.....-..470..-----..-...480------..--....-----..490...-------..-------...500.......510-----.......520.......530....-...540-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MMG
S
P
V
S
H
L
L
A
G
F
C
V
W
V
V
------
L
G
W
VGGS-------VPNLGP
A
E
Q
E
Q
N
H
----------
Y
L
A
Q
L
F
G
L
Y----G----E--NGTL
T
A
G
G
---------
L
A
R
L
L
--------------
H
-
S
LGLG
R
V
Q
G
L
R----------------LGQHGPLT-GRAASPAA--DNSTHRP------------QNPE
L
S
V
-
D
V
WAGMPLG-PSGW------GDLEESKAPHLP-----------RGPAP
S
G
L
D
L
L
H
------
R
L
L
L
L
D
H
S
--------
L
A
D
H
L
N
E
-
D
CLNG
S
Q
L
L
V
---NFG---------LSPAAPLT
P
R
Q
-
F
A
L
L
C
P
A
L
-----------------------
L
Y
Q
IDS
R
V
CIGAPAPA---------------P
P
G
D
L
------
L
S
A
L
L
Q
S
--
A
L
A
V
L
L
L
S--LP
S
P
L
-----------
S
L
L
-------
L
L
R
LL-------
G
P
R
L
L
R
P
------
L
L
G
F
L
---
G
A
L
A
V
G
--------
T
L
C
G
D
A
----
L
L
---
H
LLPH-AQEGRHAG-PGGLPEKDL-G
P
G
L
S
-------
V
L
G
G
L
F
L
L
F
------------
V
L
E
--------------
N
M
L
G
L
-
L
R
HR----GL
R
--------------
P
--------
R
--------------------
C
-----
C
R
R
K
RRNLETRNLD-----PE-NGSG
M
A
LQP--------LQAAPEPGAQGQRE---K-----NSQHPP----------ALAPPGHQGHSHGHQGG-T
D
I
T
W
---
M
V
L
LGD
G
L
H
N
LT----DG
L
A
-I---GA
A
F
S
D
G
F
SS
G
L
S
T
T
L
A
V
F
----------
C
H
E
L
P
H
E
L
G
----
D
F
A
M
L
L
Q
-----S
G
L
S
F
R
R
---------
L
L
L
L
S
L
V
S
---------
G
A
LGL
G
G
A
V
L
GVGLS-LGPVPL
T
-----
P
W
-
V
F
G
V
T
-------
A
G
--
V
F
L
Y
-----
V
A
L
V
-
D
M
L
-------
P
A
-------LLRPPEPLP
T
P
H
V
L
L
Q
-----
G
L
G
L
L
LGG
G
L
M
L
A
I
T
L
L
E
ERLLPV-TTEG---
26
Fugue
89.55
21%
-83
- C2 -
4NL4
1
?
H:
[18-747]
SVAHVALPVPLPRTFD
Y
L
L
P
E
G
M
A
V
K
A
G
C
R
V
R
V
P
FGKQER
I
G
I
V
A
A
V
SERSELP
L
D
E
L
K
P
V
A
E
A
L
D
D
EPVFSTTVWR
L
L
M
W
A
A
E
Y
Y
----
H
----
H
P-
I
G
D
V
L
F
H
A
---------
L
P
V
M
L
RQGKPASATPLWYW
F
-
A
T
E
Q
G
Q
V
V
D
L
N
----------------
G
L
K
R
S
R
K
Q
-
Q
Q
A
L
A
A
L
R
--
Q
G
K
I
W
R
H
------------
Q
V
G
E
L
E
F
-
N
E
A
A
L
Q
A
L
R
-
G
K
G
L
------
A
E
L
A
C
E
A
T
D
W
R
S
AYSVAGERLRL
N
T
E
Q
A
T
A
V
G
A
I
H
SAADRF
S
A
W
L
L
A
G
I
TGSGKTEV
Y
L
S
V
L
E
N
-
V
L
A
Q
G
R
Q
A
L
V
MVP
E
I
G
---------
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
A
P
V
E
V
L
-----------------------
H
S
G
L
N
D
S
E
R
L
S
A
W
L
K
A
---------------
K
N
G
E
A
AIVIGT
R
S
S
L
F
T
P
FK
D
L
G
V
I
V
I
D
EE
H
D
S
S
Y
KQQEGWRYHAR
D
L
A
-------
V
W
R
A
H
-------
S
E
Q
I
--
P
------
I
I
L
G
S
---
A
T
P
A
L
E
--------
T
L
H
N
V
R
QGKY
R
Q
---
L
T
L
S
K
-
P
A
Q
Q
H
V
L
D
-
L
K
G
Q
P
L
Q
A
--
G
L
S
P
A
-------
L
I
S
R
M
R
Q
H
L
------------
Q
A
D
--------------
N
Q
V
I
L
F
L
N
R
R
----
G
F
A
PALLCHDCGWIAEC
P
--------
R
--------------------
C
DSYYT
L
H
Q
A
Q
H
H
L
R
C
H
H
C
D
SQRPI
P
R
-
Q
C
P
S
C
G
S
T
H
--------
L
V
P
V
G
I
G
T
E
Q
L
E
Q
A
---
L
-----
A
P
L
F
P
E
----------
V
P
I
S
R
I
D
R
H
L
A
A
V
H
R
G
G
-
A
R
I
L
I
GTQ
M
L
A
K
G
H
H
F
P
D
V
T
----
L
V
S
L
-
L
DVD
G
A
L
F
S
A
D
F
R
S
--
A
E
R
F
A
Q
L
----------
Y
T
Q
V
S
G
R
A
G
RAGK
Q
G
E
V
I
L
Q
-----
T
H
H
P
E
H
P
---------
L
L
Q
T
L
L
Y
K
---------
G
Y
D
A
F
A
E
Q
A
L
A
E
R
Q
T
-
M
Q
L
P
P
W
T
-----
S
H
-
V
L
I
R
A
EDHNNQQ
A
P
--
L
F
L
Q
-----
Q
L
R
N
-
L
L
Q
-------
A
S
PLADEKL
W
V
L
G
P
V
P
A
L
R
W
Q
I
L
L
Q
HPSRV
R
L
Q
H
I
V
S
G
T
L
A
L
I
N
T
L
P
E
A
W
V
L
D
V
D
P
I
E
G
---
30
Fugue
72.99
16%
-72
- C1 -
4IUW
2
?
A:
[4-633]
----------------
L
P
R
I
Q
D
D
L
Y
L
A
V
N
G
E
W
Q
A
------
K
T
P
I
P
P
D
-------
K
S
V
V
S
A
D
S
N
L
T
D
D
----------
I
R
Q
K
L
V
A
D
L
S
T
M
T
K
----
T
--
A
K
T
L
P
L
Q
Y
---------
A
A
R
L
F
--------------
A
-
K
A
N
-
D
Q
T
R
R
Q
Q
----------------
L
G
I
-
E
P
V
R
-
D
R
I
S
F
L
M
A
LT
T
L
D
Q
F
R
S
------------
A
M
P
K
L
V
A
-
D
Q
Y
V
-
L
P
I
S
-
P
Y
V
D
------
A
D
M
H
D
A
E
H
N
I
L
N
-----------
L
G
G
P
D
T
I
L
P
D
A
A
------
M
Y
N
Q
E
D
A
E
--------
N
A
A
D
L
A
A
-
W
S
Q
M
A
A
A
M
L
A
---
A
V
G
FS
Q
T
D
Q
T
A
Y
V
E
A
A
K
R
F
D
R
R
L
-
A
D
Y
V
P
A
N
V
-----------------------
D
L
A
V
D
S
T
Y
D
N
P
L
S
W
Q
A
---------------
F
E
D
A
A
------
G
Y
L
G
I
P
Q
--
A
F
A
T
Y
M
P
Q
--
T
P
A
K
V
-----------
N
A
V
VPAYLPH
L
S
K
L
L
-------
T
P
D
N
Y
S
E
------
W
H
A
W
M
V
I
N
E
L
L
T
C
A
--------
T
Y
L
S
D
D
----
L
R
---
Q
L
A
G
Q
-
Y
D
R
F
L
A
G
Q
-
P
E
A
S
S
W
T
K
H
-
A
F
G
I
A
N
E
YF
D
D
-
V
I
G
Q
Y
Y
G
Q
T
YFG
A
D
A
K
A
D
V
T
A
M
V
K
--------------
Q
I
L
A
Q
-
Y
R
V
Q
----
L
E
N
--------------
N
TWLS
P
A
T
K
Q
--------------------
K
-----
A
M
R
K
L
A
T
M
Q
V
K
M
G
Y
-----
P
A
-
R
L
F
S
L
Y
D
H
L
S
V
D
VDDD
L
L
T
A
I
L
K
L
S
A
Q
T
Q
A
F
---
W
F
K
Q
L
G
Q
T
V
D
R
N
----------
Q
W
N
M
P
G
H
L
V
N
A
S
Y
D
P
L
K
-
N
D
I
T
F
P
--
A
G
I
L
Q
P
P
Y
Y
S
L
K
WT
R
A
E
N
L
G
G
T
---
G
A
T
I
G
H
E
I
S
H
S
F
D
N
N
G
A
L
Y
DEYGNLHNWW
T
P
A
D
K
Q
A
F
D
----
Q
L
V
K
A
M
A
-----
A
Q
F
D
G
R
D
YEG
V
K
V
N
GT
L
T
V
S
E
N
M
A
---------
D
N
A
G
M
D
V
A
L
A
L
L
G
D
Q
-
P
D
V
K
D
L
Q
-----
A
F
-
F
I
T
Y
A
-------
R
S
W
A
T
K
M
R
-----
P
E
R
A
-
K
T
V
L
R
QDVHA
P
A
-------
T
L
R
V
N
V
P
V
Q
N
F
P
A
W
Y
Q
-----
A
F
N
V
Q
P
Q
D
G
M
Y
R
Q
---
P
Q
K
R
L
T
I
W
-
H
Q
-----
27
Fugue
69.96
21%
-71
* C2 *
4O5P
-
?
A:
[5-815]
----------NFGFHI
A
P
T
H
P
V
A
G
R
L
T
Y
D
S
K
K
L
S
------
E
N
I
L
K
Q
Q
-------
S
D
E
R
V
F
S
R
A
Q
C
C
K
----------
A
I
H
I
T
L
G
F
D
----
G
----
T
--
N
N
N
D
K
A
D
G
SSVS
P
S
C
S
N
V
A
R
L
I
--------------
H
A
S
I
G
S
G
D
D
I
N
S
R
G
I
F
K
Y
Y
C
P
G
VGTVFPD
I
K
E
F
T
P
S
N
M
G
L
I
G
A
E
G
G
--
E
N
R
I
N
W
G
L
V
Q
L
V
D
A
L
F
Y
T
L
L
K
S
R
L
K
L
-
N
D
V
Q
G
L
V
E
E
M
S
T
N
W
T
V
S
TLT
G
G
L
L
E
N
G
E
K
K
R
R
-----------
A
A
L
E
P
K
L
K
E
L
E
E
------
K
L
R
Q
R
Q
N
S
G-------
Q
K
P
H
I
L
A
M
R
-------
L
Y
---
I
Y
G
---------
F
S
R
G
A
-
A
E
A
R
A
-
F
A
N
W
L
Q
E
L
T
RVSDADG
R
V
E
Y
R
F
AG
L
P
I
S
IE
F
L
G
L
F
D
T
V
A
A
V
G
L
P
F
A
A
G
H
MDWADDTMR
L
P
D
E
A
L
P
E
D
------
C
S
F
L
K
R
C
--
V
H
L
V
S
C
H
E
--
Q
R
A
S
F
-----------
P
L
D
-------
S
I
R
R
R
DMNGRRT
G
P
S
C
Y
R
K
W
T
V
E
Y
A
Y
P
G
V
H
---
S
D
V
G
G
G
YGVGNQGK
A
V
G
G
S
E
----
F
L
LS
Q
I
A
L
Q
H
M
Y
A
E
A
F
E
A
G
A
P
L
Q
V
P
E
W
R
V
M
V
P
K
I
E
A
E
F
SVS
E
E
L
A
T
R
F
N
A
W
------------
Q
A
Q
A
K
A
G
P
L
E
E
V
I
R
R
E
T
A
L
I
T
A
-
W
R
I
D
R
YAG
G
L
R
--------------
N
--------
K
A
F
F
A
N
VPPDMP
E
A
Q
Q
K
A
W
E
A
L
-----
H
K
R
R
S
R
E
Y
A
A
A
Q
Q
L
-----
P
P
M
S
A
A
E
Q
A
E
W
D
--------
R
N
V
A
L
I
G
G
E
D
Q
L
R
D
LRV
E
-----
K
Q
F
D
P
P
L
D
Q
R
Q
L
L
G
A
A
A
E
F
A
H
D
Y
K
G
D
W
G
V
L
D
D
G
M
T
V
G
G
V
---
I
D
L
L
L
G
G
T
V
F
L
I
----
N
E
E
D
-
E
---
A
E
E
Y
S
Q
I
H
R
D
G
S
A
R
Y
H
Q
L
F
----------
S
A
P
D
R
V
A
P
G
Q
E
--
K
L
V
A
L
F
D
EQVHD
S
R
A
P
F
T
D
---------
Y
F
R
Y
R
L
V
H
FDNESN
K
R
L
S
V
L
A
T
A
G
R
V
V
G
V
G
V
-M
L
A
S
V
G
L
S
V
K
R
R
D
P
R
M
L
L
G
G
L
-------
P
E
--
I
S
A
F
D
PLTG
I
A
L
P
M
V
G
G
-------
A
A
-------
L
D
N
L
R
A
F
T
R
E
P
G
D
K
V
E
-----
Q
I
G
Q
L
P
P
P
P
P
L
A
V
A
A
V
Q
S
P
A
L
Q
Q
V
-
L
L
A
Q
Q
T
V
29
Fugue
53.48
16%
-103
- C2 -
1MZJ
2
FABH_STRLI
A:
[3-336]
----------------------------------------------------------
G
L
R
V
P
E
R
R
F
----------
S
R
V
L
G
V
G
S
Y
----
R
----
P
--
R
R
E
V
S
N
K
E
---------
V
C
T
W
I
--------------------------------------------------------------------------------------
D
S
T
E
E
W
I
E
T
R
T
G
-------------------------------------------
I
R
S
------
R
R
I
A
E
P
--------------------------------------------------------
D
E
T
I
Q
V
M
-----------------------
G
V
A
A
S
R
R
A
L
E
H
A
G
V
D
P
---------------
A
E
I
D
L
------
V
V
V
S
T
M
T
--
N
F
-----
V
--
H
T
P
P
L
-----------
S
V
A
-------
I
A
H
E
L
-------
G
A
D
-
N
A
G
------
G
F
D
L
S
---
A
A
---------------
C
A
G
----
F
C
---
H
A
L
S
I
-
A
A
D
A
V
E
S
G
-
G
S
R
-----------------------
H
V
L
V
V
------------
A
T
E
--------------
R
M
T
D
V
-
I
D
L
A
------------------------------------------------------------------
D
R
S
L
S
-----
F
L
-
F
G
D
G
A
G
A
A
V
--------
V
G
P
S
-
D
-----------
V
-----
P
G
I
G
P
V
----------
V
R
G
I
D
G
T
G
L
G
S
L
H
M
S
S
S
-
W
D
Q
Y
V
---
E
D
P
S
V
G
R
P
A
L
V
M
----
D
G
K
R
-
V
---
F
R
W
A
V
A
D
V
V
P
A
A
R
E
A
L
E
V
A
----------
G
L
-
T
V
G
D
L
-----
V
A
F
V
P
H
Q
-----
A
N
--------------
L
R
I
I
D
V
L
V
---------
D
R
L
G
V
P
E
H
V
V
V
S
-----
R
D
A
E
D
T
----------
G
N
T
-------
S
S
--
A
S
V
A
-----
L
A
L
D
-
R
L
V
-------
R
S
------------
G
A
V
P
G
G
---
G
P
-----
A
L
M
I
G
F
G
A
G
L
S
Y
A
G
Q
A
L
L
L
P
D
P
P
S
--------
25
Fugue
45.98
20%
5
- C3 -
1J7R
-
CAVP_BRALA
A:
[8-84]
---------------------------------------------------------
L
G
P
E
E
K
D
E
C
M
----------
K
I
F
D
I
F
D
R
N
----
A
----
E
--
N
-
I
A
P
V
S
D
---------
T
M
D
M
L
--------------
T
-
K
L
G
----
Q
T
Y
T
----------------
K
R
E
T
E
A
I
M
-
K
E
A
R
G
P
K
G
--
D
K
K
N
I
G
P
------------
E
E
W
L
T
L
C
-
S
K
W
V
R
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
43.18
23%
-51
- C3 -
3I5G
-
MLE_TODPA
C:
[5-43]
--------------------------------------------------------------
K
D
E
I
E
----------
E
V
R
E
V
F
D
L
F
----
D
F
W
D
G
R
--
D
G
D
V
D
A
A
K
---------
V
G
D
L
L
--------------
R
-
C
L
G
M
N
P
T
E
A
Q
V
----------------
H
Q
H
G
G
T
K
K
-
M
G
E
K
A
Y
K
L
--
E
E
I
L
P
I
Y
------------
E
E
M
S
S
K
D
-
T
G
T
A
A
D
E
F
M
-
E
A
F
K
------
T
F
D
R
E
G
Q
G
L
I
S
S
-----------
A
E
I
R
N
V
L
K
M
L
G
E
------
R
I
T
E
D
Q
C
N
--------
D
I
F
T
F
C
D
-
I
R
E
D
I
D
G
N
I
K
---
Y
E
D
---------
L
M
K
K
V
M
A
G
P
F
P
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
40.05
24%
5
- C3 -
2JOJ
-
?
A:
[28-62]
---------------------------------------------------------------
E
Q
K
Q
----------
E
I
K
E
A
F
D
L
F
----
D
TN--
K
--
T
G
S
I
D
Y
H
E
---------
L
K
V
A
M
--------------
R
-
A
L
G
F
D
V
K
K
P
E
I
----------------
L
E
L
M
N
E
Y
D
-
R
E
G
N
G
Y
I
G
--
F
D
D
F
L
D
I
------------
M
T
E
K
I
K
N
-
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
36.30
29%
-68
- C3 -
1WDC
-
MLE_ARGIR
C:
[4-42]
-------------------------------------------------------------
S
Q
D
E
I
D
----------
D
L
K
D
V
F
E
L
F
D
F
W
D
G
----
R
--
D
G
A
V
D
A
F
K
---------
L
G
D
V
C
--------------
R
-
C
L
G
I
N
P
R
N
E
D
V
----------------
F
A
V
G
G
T
H
K
-
M
G
E
K
S
L
P
F
--
E
E
F
L
P
A
Y
------------
E
G
L
M
D
C
E
-
Q
G
T
F
A
D
Y
M
E
-
A
F
K
T
------
F
D
R
E
G
Q
G
F
I
S
G
A
-----------
E
L
R
H
V
L
T
A
L
G
E
R
------
L
S
D
E
D
V
D
E
--------
I
I
K
L
T
D
L
-
Q
E
D
L
E
G
N
V
K
Y
---
E
D
F
---------
V
K
K
V
M
A
G
P
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
35.97
23%
-16
- C3 -
3BQ3
-
DCN1_YEAST
A:
[70-104]
--------------------------------------------------------------
P
V
Y
P
K
----------
E
L
T
Q
V
F
E
H
Y
----
I
----
N
--
N
N
L
F
D
I
D
S
---------
L
V
K
F
I
--------------
E
-
E
L
G
Y
N
L
E
D
L
A
T
----------------
L
C
L
A
H
L
L
G
-
Y
K
K
L
E
E
P
L
--
K
R
E
D
F
L
S
------------
T
W
F
M
Q
G
C
-
S
T
I
S
D
M
Q
E
C
-
I
K
T
L
------
D
V
K
L
H
E
D
L
Q
Y
F
T
-----------
Q
I
Y
N
Y
A
F
N
L
I
L
D
------
P
N
R
K
D
I
D
T
--------
D
E
G
I
Q
Y
W
-
K
L
F
F
Q
P
E
Y
P
V
---
R
M
E
---------
P
D
L
L
E
A
W
F
R
F
L
-
R
D
E
G
K
T
T
I
-----------------------
S
K
D
T
W
R
M
L
L
L
F
F
K
R
Y
P
---------------
T
I
Q
K
I
------
I
S
D
Y
D
E
T
--
A
A
W
P
F
I
I
D
--
E
F
Y
E
C
-----------
L
Q
D
-------
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
35.22
27%
-14
- C3 -
3KEV
-
?
A:
[6-40]
-----------------------------------------------------------------
K
K
----------
A
I
L
E
L
F
Q
T
Y
----
K
----
E
PL
G
N
Y
I
G
A
E
G
---------
L
Q
R
L
F
--------------
E
-
D
I
Q
V
D
P
S
D
V
V
T
----------------
L
V
L
A
W
K
L
K
-
A
S
S
T
C
E
F
S
--
E
K
E
F
V
E
G
------------
L
A
N
L
Q
V
D
-
S
L
E
K
L
K
R
K
L
-
S
S
L
R
------
K
E
I
E
D
P
S
K
F
R
A
F
-----------
Y
Q
F
V
F
Q
Y
S
K
E
P
S
------
Q
R
S
L
P
A
E
T
--------
A
M
A
L
W
D
V
-
L
L
R
G
R
F
S
L
L
D
---
S
W
L
---------
E
F
L
K
N
N
T
H
S
I
S
-
R
D
T
W
N
L
L
Y
-----------------------
D
F
S
Q
L
K
D
L
S
D
Y
D
A
W
P
V
---------------
L
I
D
D
F
------
V
K
W
L
K
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
33.78
23%
-43
- C3 -
1GGW
-
MLR4_SCHPO
A:
[5-37]
-----------------------------------------------------------------
D
S
----------
P
Y
K
Q
A
F
S
L
F
----
D
RH--
G
--
T
G
R
I
P
K
T
S
---------
I
G
D
L
L
--------------
R
-
A
C
G
Q
N
P
T
L
A
E
I
----------------
T
E
I
E
S
T
L
P
-
A
E
V
D
M
E
Q
F
--
L
Q
V
L
N
R
P
------------
N
G
F
D
M
P
G
-
D
P
E
E
F
V
K
G
F
-
Q
V
F
D
------
K
D
A
T
G
M
I
G
V
G
E
L
-----------
R
Y
V
L
T
S
L
G
E
K
L
S
------
N
E
E
M
D
E
L
L
--------
K
G
V
P
V
K
D
-
G
M
V
N
Y
H
D
F
V
Q
---
M
I
L
---------
A
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
31.36
14%
-0
- C3 -
1J7Q
-
CAVP_BRALA
A:
[9-45]
-------------------------------------------------------------
G
P
E
E
K
D
----------
E
C
M
K
I
F
D
I
F
----
D
RN--
A
--
E
N
I
A
P
V
S
D
---------
T
M
D
M
L
--------------
T
-
K
L
G
Q
T
Y
T
K
R
E
T
----------------
E
A
I
M
K
E
A
R
-
G
P
K
G
D
K
K
N
--
I
G
P
E
E
W
L
------------
T
L
C
S
K
W
V
-
R
Q
D
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
28.66
23%
-11
- C3 -
3TDU
1
CUL1_HUMAN (first)
A:
[6-38]
------------------------------------------------------------------------------
L
E
Q
L
Y
N
R
Y
----
K
DPQ-
D
--
E
N
K
I
G
I
D
G
---------
I
Q
Q
F
C
--------------
D
-
D
L
A
L
D
P
A
S
I
S
V
----------------
L
I
I
A
W
K
F
R
-
A
A
T
Q
C
E
F
S
--
K
Q
E
F
M
D
G
------------
M
T
E
L
G
C
D
-
S
I
E
K
L
K
A
Q
I
-
P
K
M
E
------
Q
E
L
K
E
P
G
R
F
K
D
F
-----------
Y
Q
F
T
F
N
F
A
K
N
P
G
------
Q
K
G
L
D
L
E
M
--------
A
I
A
Y
W
N
L
-
V
L
N
G
R
F
K
F
L
D
---
L
W
N
---------
K
F
L
L
E
H
H
K
R
S
I
-
P
K
D
T
W
N
L
L
-----------------------
L
D
F
S
T
M
I
A
D
D
M
S
N
Y
D
E
---------------
E
G
A
W
P
------
V
L
I
D
D
F
V
--
E
F
A
R
P
Q
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
27.60
17%
226
- C3 -
2KYA
-
?
A:
[1-34]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
K
--------
K
N
I
L
P
Q
Q
G
Q
P
V
I
R
L
---
T
-----
A
G
Q
L
S
S
----------
Q
L
A
E
L
S
E
E
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
26.44
15%
-2
- C3 -
2ZND
1
PDCD6_HUMAN
A:
[6-38]
-----------------------------------------------------------------
Q
S
----------
F
L
W
N
V
F
Q
R
V
----
D
K
D--
R
--
S
G
V
I
S
D
T
E
---------
L
Q
Q
A
L
--------------
S
-
N
G
T
W
T
P
F
N
P
V
T
----------------
V
R
S
I
I
S
M
F
-
D
R
E
N
K
A
G
V
--
N
F
S
E
F
T
G
------------
V
W
K
Y
I
T
D
-
W
Q
N
V
F
R
T
Y
D
-
R
D
N
S
------
G
M
I
D
K
N
E
L
K
Q
A
L
-----------
S
G
F
G
Y
R
L
S
D
Q
F
H
------
D
I
L
I
R
K
F
D
--------
R
Q
G
R
G
Q
I
-
A
F
D
D
F
I
Q
G
C
I
---
V
L
Q
---------
R
L
T
D
I
F
R
R
Y
D
T
-
D
Q
D
G
W
I
Q
V
-----------------------
S
Y
E
Q
Y
L
S
M
V
F
S
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
26.04
19%
201
- C3 -
1KIL
-
CPLX1_RAT
E:
[9-49]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
E
E
E
R
Q
E
A
L
R
Q
-----
A
E
-
E
E
R
K
A
K
Y
A
K
--------
M
E
A
E
R
E
V
M
R
Q
G
I
R
D
---
K
-----
Y
G
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
25.35
22%
10
- C3 -
1DTL
3
TNNC1_CHICK
A:
[13-51]
-------------------------------------------------------------
T
E
E
Q
K
N
----------
E
F
K
A
A
F
D
I
F
----
V
LGA-
E
--
D
G
S
I
S
T
K
E
---------
L
G
K
V
M
--------------
R
-
M
L
G
Q
N
P
T
P
E
E
L
----------------
Q
E
M
I
D
E
V
D
-
E
D
G
S
G
T
V
D
--
F
D
E
F
L
V
M
------------
M
V
R
S
M
K
K
-
S
E
E
E
L
S
D
L
F
-
R
M
F
D
------
K
N
A
D
G
Y
I
D
L
E
E
L
-----------
K
I
M
L
Q
A
T
T
I
T
E
D
------
D
I
E
E
L
M
K
D
--------
G
D
K
N
N
D
G
-
R
I
D
Y
D
E
F
L
E
F
---
M
K
G
---------
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
24.56
18%
39
- C3 -
2OPO
-
POLC3_CHEAL
A:
[7-41]
--------------------------------------------------------------
P
Q
D
I
A
----------
D
R
E
R
I
F
K
R
F
----
D
T
N--
G
--
D
G
K
I
S
S
S
E
---------
L
G
D
A
L
--------------
K
-
T
L
G
S
V
T
P
D
E
V
R
----------------
R
M
M
A
E
I
D
T
-
D
G
D
G
F
I
S
F
--
D
E
F
T
D
F
A
------------
R
A
N
R
G
L
V
-
K
D
V
S
K
I
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
23.29
23%
-6
- C3 -
3J04
-
MLRM_CHICK
B:
[27-63]
--------------------------------------------------------------
Q
S
Q
I
Q
----------
E
F
K
E
A
F
N
M
I
----
D
QN--
R
--
D
G
F
I
D
K
E
D
---------
L
H
D
M
L
--------------
A
-
S
M
G
K
N
P
T
D
E
Y
L
----------------
E
G
M
M
S
E
A
P
-
G
P
I
N
F
T
M
F
--
L
T
M
F
G
E
K
------------
L
N
G
T
D
P
E
-
D
V
I
R
N
A
F
A
C
-
F
D
E
E
------
A
S
G
F
I
H
E
D
H
L
R
E
-----------
L
L
T
T
M
G
D
R
F
T
D
E
------
E
V
D
E
M
Y
R
E
--------
A
P
I
D
K
K
G
-
N
F
N
Y
V
E
F
T
R
I
---
L
K
H
---------
G
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
22.52
29%
121
- C4 -
3PJN
1
TA34_TREPA
A:
[62-115]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
R
D
V
G
-----
P
L
-
H
V
G
G
V
Y
F
Q
P
--------
V
E
M
H
P
A
P
G
A
Q
P
S
K
E
---
E
-----
A
D
C
H
I
E
----------
A
--------
D
I
H
A
N
E
A
G
-
K
D
L
G
Y
---
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------