@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S52A3_HUMAN: (2015-12-11 )
MAFLMHLLVCVFGMGSWVTINGLWVELPLLVMELPEGWYLPSYLTVVIQLANIGPLLVTLLHHFRPSCLSEVPIIFTLLGVGTVTCIIFAFLWNMTSWVLDGHHSIAFLVLTFFLALVDCTSSVTFLPFMSRLPTYYLTTFFVGEGLSGLLPALVALAQGSGLTTCVNVTEISDSVPSPVPTRETDIAQGVPRALVSALPGMEAPLSHLESRYLPAHFSPLVFFLLLSIMMACCLVAFFVLQRQPRCWEASVEDLLNDQVTLHSIRPREENDLGPAGTVDSSQGQGYLEEKAAPCCPAHLAFIYTLVAFVNALTNGMLPSVQTYSCLSYGPVAYHLAATLSIVANPLASLVSMFLPNRSLLFLGVLSVLGTCFGGYNMAMAVMSPCPLLQGHWGGEVLIVASWVLFSGCLSYVKVMLGVVLRDLSRSALLWCGAAVQLGSLLGALLMFPLVNVLRLFSSADFCNLHCPA
Atome Classification :
(20 SA)
----------------------------------------------....----.....10........20....-....-------.30...-------.....40.---......---------.50...------.....60........70...--.....80........90........100.......110......-----.120.-------------.--.-....130-..-------.....-..140.......150.......160--.......170.......180-.......190--........200-....-....210.......--------220..----......230.......240.-----------......250--.......---------------.---------.260-..-.....270----.......------------------280......--------.290--..--.......300....----...310.......320.....-..330..-----......--340----.........350......-----.360...--------.....-------.370...----....380....-.------..390.......400.......410-----.........420--....---...430......---.440.......450....-...460.......-------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------
M
A
F
L
----
M
H
L
L
V
C
V
FGMG
S
W
V
T
I
-
N
G
L
W
-
V
EL
P
-------
L
L
V
M
EL-------PEGWY
L
P
S
---
Y
L
T
V
V
I
---------
Q
LAN
I
G
------
P
L
L
V
T
L
L
H
HF
R
P
S
C
L
SEV
P
I
--
I
F
T
L
L
G
V
G
T
V
T
C
I
I
F
A
F
L
W
N
M
T
S
W
V
LDGH
H
S
I
A
F
L
V
L
T
F
F
L
A
L
V
-----
D
CTSS-------------
V
--
T
-
F
L
P
F
M
---
S
R-------L
P
T
Y
Y
-
L
T
T
F
F
V
G
E
G
L
S
G
L
L
P
A
L
V
A
L
AQGSG--
L
T
T
C
V
N
V
T
E
ISDSVPSPVPT-R
E
T
D
I
A
Q
G
-
V
--
P
R
A
L
V
S
ALPG--M
E
A
P
-
L
S
H
L
E
S
RYLP
A
H
F
S
--------
P
L
-
V
F
----
F
L
L
L
S
I
M
M
A
C
C
L
V
A
F
F
V
L
QR-----------QPR
C
W
E
A
----
S
V
E
D
L
LN---------------D---------Q
V
T
L
-
H
S-IRPREEND----LGPAGTV------------------D
S
S
QGQG
Y
L
--------
E
E----KA--APC
C
P
A
H
L
A
F
I
Y
T
L
----
V
A
F
V
N
A
L
TNGMLPSVQ
T
Y
SCL-SYG
P
-
V
A
-----
Y
H
L
A
A
T
--
L
------
S
I
V
A
N
P
L
A
S
L
V
S
M
FLPN
R
-----
S
L
--
L
F
L
--------
G
V
L
S
V
-------
L
G
T
CFG
G
----
Y
N
M
A
M
A
V
MSPC-P------LLQGHWG
G
E
V
L
I
V
A
S
W
V
L
F
S
G
C
L
-------
S
Y
V
K
V
M
L
G
V
V
L
R
--
D
L
S
R
---
S
A
L
L
W
C
G
A
A
V
Q
L
---
G
S
L
L
G
A
L
L
M
F
P
L
V
N
V
L
R
L
-FSSADFCNLHCPA-------------------------
16
Fugue
86.63
18%
-129
- C5 -
4ZFV
2
?
A:
[10-445]
------------------------------------------------------
N
V
L
D
F
T
V
L
G
L
N
S
G
T
S
M
-
D
G
I
D
-
C
A
L
C
-------
H
F
Y
Q
K
T
-------
P
D
A
-----------------------------------
P
M
E
F
E
L
L
E
Y
------
G
E
V
P
-------
L
A
Q
P
I
K
Q
R
V
M
R
M
I
L
E
D
T
T
S
--
P
S
E
L
S
E
V
N
V
I
L
G
E
H
F
A
D
A
V
-----
R
Q
F
A
A
-------------
E
R
N
V
-
D
L
S
T
I
---
D
A
-------
I
A
S
H
G
-
Q
T
I
W
L
L
S
M
P
E
E
G
Q
V
K
S
A
L
T
M
A
E
G
A
I
--
L
A
S
R
T
G
I
T
S
I
T
D
-------
F
-
R
I
S
D
Q
A
A
G
-----------
R
Q
G
----
A
P
-
L
I
A
F
F
D
A
L
L
L
H
H
P
T
--------
K
L
-
R
A
----
C
Q
N
I
G
G
I
A
N
V
C
F
I
P
P
D
V
D
G
R
RTD--------
E
Y
Y
D
F
D
T
----
G
P
G
N
V
F
I
---------------
D
---------
A
V
V
R
-
H
F
-
T
N
G
E
Q
E
Y
D
KDG
A
M
G
K
R
G
K
V
------------------
D
Q
E
L
V
D
D
F
L
--------
K
M
----
P
Y
--
F
Q
L
D
P
P
K
---
T
T
G
R
----
E
V
F
R
D
T
L
A
H
D
L
I
R
R
A
E
A
K
G
-----
L
S
-
P
D
-----
D
I
V
A
T
T
--
T
------
R
I
T
A
Q
A
I
V
D
H
Y
R
R
Y
A
P
S
Q
-----
E
I
D
E
I
F
M
C
G
GGAYN
P
N
I
V
E
F
-------
I
Q
Q
S
Y
P
N
----
T
K
I
M
M
L
D
E
A
G
V
-
P
AGA
K
E
A
I
T
F
A
W
Q
G
M
E
A
L
V
G
R
S
I
P
V
P
T
R
V
E
-------
T
R
Q
H
Y
V
L
G
K
V
S
P
--
G
L
N
Y
---
R
S
V
M
K
K
G
M
A
F
G
G
---
D
A
Q
Q
L
P
W
V
S
E
M
I
V
K
K
K
G
K
-
V
I
T
N
N
W
A
G
S
H
H
H
H
-------------------------
23
Fugue
78.48
19%
-157
- C4 -
4RAP
-
TIBC_ECOH1
A:
[10-391]
---------------------------------------ITPPDTP
T
Q
A
G
----
P
E
N
I
F
Y
D
F
N
D
G
A
R
V
L
L
P
E
G
K
W
H
V
R
L
L
DADSENI
L
F
C
C
D
V
-------
D
K
G
W
V
T
S
S
KKY
F
V
R
F
R
I
---------
Q
V
F
R
Q
G
AT----
P
L
L
D
E
T
L
K
------
L
K
D
R
P
V
--
L
I
S
F
-
P
T
G
T
-----------------
L
G
D
L
L
G
W
F
P
Y
A
E
R
F
Q
S
L
H
-----
K
C
R
L
E
-------------
C
--
T
M
S
Q
D
I
I
---
D
L
-------
L
A
P
Q
Y
-
P
Q
I
Q
F
S
T
P
D
K
P
R
T
V
A
P
Y
----------
A
T
Y
R
V
G
L
Y
F
G
G
D
T
N
N
Q
P
V
D
F
-
R
K
V
G
F
H
R
S
-
A
--
G
Y
I
L
G
V
D
P
R
E
--
A
P
V
R
-
L
D
L
S
A
P
R
V
I
A
A
-----------
P
Y
-
V
C
----
I
A
T
Q
S
T
----
C
Q
A
K
Y
W
---
N
-----------
N
G
T
G
W
S
E
----
V
I
A
H
L
K
S
---------------
L
---------
G
Y
R
V
M
C
I
-
D
R
-----------------------------------
D
A
H
Y
G
Q
G
F
-----------------------------------------------------
V
W
N
H
I
-
P
W
G
A
-
E
D
-----
F
T
G
K
L
P
--
L
------
Q
E
R
V
N
L
L
R
---------
H
-----
A
S
--
F
F
I
--------
G
L
P
S
G
-------
L
S
W
L
A
W
A
----
T
R
I
P
V
V
L
I
S
G
F
-
S
------
L
P
N
S
E
F
Y
T
P
W
R
V
F
N
S
H
G
C
Y
-
G
C
W
-------
D
D
T
S
L
---------
N
F
D
H
---
H
D
F
L
W
C
P
R
H
K
N
T
---
D
R
Q
F
E
C
T
R
L
I
T
G
A
Q
V
N
G
V
-
I
N
K
L
H
R
S
L
T
-----------------------------
15
Fugue
76.54
17%
-134
- C3 -
4Q86
1
YCAO_ECOLI
A:
[2-583]
---------------------------------------------T
Q
T
F
I
P
GKD
A
A
L
E
D
S
I
A
R
F
Q
Q
K
L
S
D
-
L
G
F
Q
-
I
E
E
A
-------
S
W
L
N
P
V
-------
P
N
V
W
S
V
H
I
---
R
D
K
E
C
A
---------
L
C
F
T
N
G
K
G
AT
K
K
A
A
L
A
S
A
L
G
E
Y
F
E
R
L
S
T
N
Y
F
F
--
A
D
F
W
L
G
E
T
I
A
N
G
P
-
F
V
H
Y
P
N
E
K
W
F
P
L
T
E
N
D
D
V
P
E
G
L
L
D
D
R
L
R
A
F
Y
D
P
EN
E
L
T
G
S
MLIDLQSGNEDR
G
I
--
C
-
G
L
P
F
T
---
R
Q
SDN
Q
T
V
Y
I
P
M
N
I
-
I
G
N
L
Y
V
S
N
G
M
S
A
G
N
T
R
N
E
A
R
V
Q
G
L
S
E
V
F
E
R
Y
V
K
N
R
I
I
A
E
S
I
S
L
P
-----------
E
-
I
--
P
A
D
V
L
A
R
Y
P
A
--
V
V
E
A
-
I
E
T
L
E
A
E
G
F
P
I
F
A
Y
D
GSLGGQY
P
V
-
I
C
----
V
V
L
F
N
P
A
N
G
T
C
F
A
S
F
G
A
H
P
D
-----------
F
G
V
A
L
E
R
----
T
V
T
E
L
L
Q
GRGLKDLDVFTPPTF
D
---------
D
E
E
V
-
A
E
-
H
T
N
L
E
T
H
F
----
I
D
S
S
G
L
I
S
WDLFKQDADYPFVDWNF
S
G
T
T
E
E
E
F
A
--------
T
L
----
M
A
--
I
F
N
K
E
D
K
E
V
Y
I
A
D
Y
EHLG
V
Y
A
C
R
I
I
V
P
G
M
S
D
I
Y
P
A
E
D
L
W
L
A
N
N
S
-
M
G
-----
S
H
L
R
E
T
--
I
L
S
LPGS
E
W
E
K
E
D
Y
L
N
L
I
E
Q
L
D
E
E
G
-----
F
D
--
D
F
T
--------
R
V
R
E
L
-------
L
G
L
A
T
G
S
DNGW
Y
T
L
R
I
G
E
L
K
A
M
-
L
------
A
L
A
G
G
D
L
E
Q
A
L
V
W
T
E
W
T
M
E
F
N
S
S
VFS
P
E
R
A
N
Y
Y
R
C
L
Q
T
L
L
L
L
A
Q
E
E
D
R
---
Q
P
L
Q
Y
L
N
A
F
V
R
M
YG
A
D
A
V
E
A
A
S
A
A
M
S
G
E
A
A
F
Y
G
-
L
Q
P
V
D
S
-
D
L
H
A
F
A
A
H
Q
S
L
L
K
A
Y
E
K
L
Q
R
A
K
A
A
F------
19
Fugue
67.55
15%
-116
- C2 -
4BIJ
-
TERL_BPT7
A:
[1-476]
----------------------------------------------
M
S
T
Q
----
S
N
R
N
A
L
V
--------
V
-
A
Q
L
K
-
G
D
F
V
-------
A
F
L
F
V
L
-------
W
K
A
L
N
L
P
V
---
P
T
K
C
Q
I
---------
D
M
A
K
V
--------------------------------
L
A
N
G
D
N
K
K
F
I
L
Q
A
F
-----
R
G
I
G
K
S
F
I
T
C
A
F
V
V
W
S
L
W
R
D
P
Q
-----
L
K
I
L
I
-------------
V
--
S
-
A
S
K
E
R
---
A
D
-------
A
N
S
I
F
-
I
K
N
I
I
------
D
L
L
P
F
L
S
E
L
K
P
R
P
G
--
Q
R
D
S
V
I
S
F
D
V
G
P
A
N
P
D
H
S
P
S
V
K
S
V
G
I
T
G
Q
-
L
T
G
S
R
A
D
I
I
I
A
D
D
--
V
E
I
P
-
S
N
S
A
T
M
G
A
R
E
K
L
W
T
--------
L
V
Q
E
F
----
A
A
L
L
K
P
L
P
S
S
R
V
I
Y
L
G
T
P
Q
T
-----------
E
M
T
L
Y
K
E
----
L
E
D
N
R
G
Y
---------------
T
---------
T
I
I
W
-
P
A
-
L
Y
P
R
T
R
E
E
----
N
L
Y
Y
S
Q
R
------------------
L
A
M
L
R
A
E
Y
D
--------
E
N
PEA
L
A
G
--
T
P
T
D
P
V
R
F
D
R
D
D
L
R
----
E
R
E
L
E
Y
G
K
A
G
F
T
L
Q
F
M
L
N
P
N
L
-
S
D
A
E
K
Y
P
-----
L
R
L
R
D
A
--
I
------
V
A
A
L
D
L
E
K
A
M
H
Y
Q
W
L
P
N
R
QNIIE
D
L
--
P
N
V
--------
G
L
K
G
D
DLHTYHD
C
S
N
N
S
G
Q
----
Y
Q
Q
K
I
L
V
I
D
P
S
-
G
------
R
G
K
D
E
T
G
Y
A
V
L
Y
T
L
N
G
Y
I
Y
L
M
E
A
G------
G
F
R
D
G
Y
S
D
K
T
L
E
--
L
L
A
K
---
K
A
K
Q
W
G
V
Q
T
V
V
Y
---
E
S
N
F
G
D
G
M
F
G
K
V
F
S
P
I
L
L
K
H
H
N
C
A
M
E
E
I
R
A
R
G
MKEM
R
I
C
D
T
L
E
P
V
M
Q
T
H
R
LVIRDEV
22
Fugue
67.43
12%
-149
- C4 -
1I1Q
1
TRPE_SALTY
A:
[5-516]
K
P
T
L
E
L
L
T
C
D
A
A
Y
R
EN
P
T
A
L
F
H
Q
VCGDRPATLLL
E
S
A
DIDSKDD
L
K
S
L
L
L
----
V
D
S
A
L
R
I
T
A
L
G
D
T
V
T
I
-
Q
A
L
S
-
D
N
G
A
-------
S
L
L
P
L
L
D
T
A
LPAG
V
E
N
D
V
L
P
A
---
G
R
V
L
R
F
P
P
V
S
PLLD
E
N
A
R
L
C
S
------
L
S
V
F
D
A
F
R
L
L
Q
G
V
V
N
I
P
T
Q
E
--
R
E
A
M
F
F
G
G
L
F
A
Y
D
L
V
A
G
F
E
A
L
P
H
L
E
A
G
N
N
C
P
D
Y
C
F
Y
L
A
E
T
L
M
V
I
-----
D
H
Q
K
K
-------------
S
--
T
-
R
I
Q
A
S
L
FT
A
S
-------
D
R
E
K
Q
-
R
L
N
A
R
L
A
Y
L
S
Q
Q
L
T
Q
P
A
P
P
L
P
V
T
P
V
--
P
D
M
R
C
E
C
N
Q
S
D
D
A
F
G
A
V
V
R
Q
-
L
Q
K
A
I
R
A
G
E
I
--
F
Q
V
V
P
S
R
R
F
S
--
L
P
C
P
S
P
L
A
A
Y
Y
V
L
K
K
S
N
P
S
--------
P
Y
-
M
F
----
F
M
Q
D
N
D
F
T
L
F
G
A
S
P
E
S
S
L
K
Y
-----------
D
A
A
--------------
S
---------------
R
---------
Q
I
E
I
-
Y
P
-
I
A
G
T
R
P
R
G
----
R
R
A
D
G
T
L
------------------
D
R
D
L
D
S
R
I
E
--------
L
D
----
M
R
T
D
H
K
E
L
S
E
H
L
M
L
V
D
L
A
----
R
N
D
L
A
R
I
C
T
P
G
S
R
Y
V
A
D
L
T
K
V
-
D
R
Y
S
-
Y
V
-----
M
H
L
V
S
R
--
V
------
V
G
E
L
R
H
D
L
D
--------------
A
L
--
H
A
Y
--------
R
A
C
M
N
-------
M
G
T
L
S
G
A
----
P
--
K
V
R
A
M
Q
L
I
-
A
------
D
A
E
G
Q
R
R
G
S
Y
G
G
A
V
G
Y
F
T
A
H
G
D
L
-------
D
T
C
I
V
I
R
S
A
L
V
E
--
N
--
G
---
I
A
T
V
Q
A
G
A
G
I
V
L
---
D
S
V
P
Q
S
E
A
D
E
T
R
N
K
A
R
A
V
-
L
R
A
I
A
T
A
H
H
A
----------------------------
14
Fugue
63.24
11%
-117
* C4 *
2EUA
1
MENF_ECOLI
A:
[2-429]
-------------------------------------------------------------------
Q
S
L
-
T
T
A
L
-
E
N
L
L
-------
R
H
L
S
Q
E
-------
I
P
A
T
P
G
I
R
---
V
I
D
I
P
F
---------
P
L
K
D
A
F
------
D
A
L
S
W
L
A
S
Q
Q
T
Y
P
Q
F
Y
W
Q
Q
R
NG
D
E
E
A
V
V
L
G
A
I
T
R
F
T
S
L
D
Q
A
Q
R
F
L
R
Q
H
P
E
H
A
D
L
R
I
W
G
L
N
A
F
D
P
S
Q
-----
G
N
L
L
L
-------------
P
--
R
-
L
E
W
R
R
---
C
G
-------
G
K
A
T
L
-
R
L
T
L
F
S
E
S
S
L
Q
H
D
A
I
Q
A
K
E
F
I
A
T
----
L
V
S
I
K
P
L
P
G
L
H
L
T
T
T
R
E
Q
H
W
P
D
K
T
G
W
T
Q
L
-
I
--
E
L
A
T
K
T
I
A
E
G
EL
D
K
V
V
-
L
A
R
A
T
D
L
H
F
A
S
P
V
N
--------
A
A
-
A
M
----
M
A
A
S
R
R
L
N
L
N
C
Y
H
F
Y
M
A
F
D
G
-----------
E
N
A
F
L
G
S
----
S
P
E
R
L
W
R
---------------
R
---------
R
D
K
A
-
L
R
-
T
E
A
L
A
-----------
G
T
V
------------------
A
N
N
P
D
D
K
Q
A
--------
Q
Q
----
L
G
--
E
W
L
-
M
A
D
D
K
N
Q
R
E
N
----
M
L
V
V
E
D
I
C
Q
R
L
Q
A
D
T
Q
-------
T
L
D
-
V
L
-----
P
P
Q
V
L
R
--
L
------
R
K
V
Q
H
L
R
R
C
I
W
T
S
L
N
K
A
D
-----
D
V
--
I
C
L
--------
H
Q
L
Q
P
-------
T
A
A
V
A
G
L
P---
R
D
L
A
R
Q
F
I
A
R
H
E
P
------
F
T
R
E
W
Y
A
G
S
A
----------
G
Y
L
-------
S
L
Q
Q
S
E
F
C
V
S
L
R
--
S
A
K
I
S
GN
V
V
R
L
Y
A
G
A
G
I
V
R
---
G
S
D
P
E
Q
E
W
Q
E
I
D
N
K
A
A
G
L
-
R
T
L
L
Q
---------------------------------
18
Fugue
56.94
18%
-112
* C5 *
4TKO
2
?
B:
[3-349]
--------------------------------------------------------------
H
R
I
E
Y
A
I
T
-
N
A
V
F
-
V
K
A
D
-------
E
------------------
L
S
---
Y
L
S
---------------------------------
F
R
V
S
----------------
G
K
V
I
E
V
Y
K
----
D
L
G
D
Y
V
K
R
G
E
----------
A
L
A
K
L
-----
D
----------------------------------------
P
T
Y
Y
E
L
E
K
R
T
L
E
K
K
M
S
A
L
L
E
K
K
K
A
L
E
I
K
I
Q
K-
L
E
K
G
L
H
I
S
L
S
A
K
K
L
K
V
E
S
L
K
-
K
K
R
E
A
L
R
E
-
K
--
L
L
Q
V
E
E
K
I
K
L
--
V
K
L
D
-
W
E
R
Y
K
S
L
F
Q
K
-
G
L
I
--------
P
R
-
R
K
----
F
E
E
V
D
T
N
L
K
V
L
L
H
E
R
E
Y
L
E
K
-----------
S
I
Q
E
I
N
T
----
E
I
K
R
A
K
K
---------------
G
---------
I
E
N
A
-
R
N
-
E
F
K
T
I
E
E
L
----
K
K
E
L
S
S
L
------------------
E
E
E
I
K
S
L
K
E
--------
R
I
----
K
T
--
A
E
Q
K
I
K
D
T
V
L
I
------------
A
P
F
D
G
V
V
A
K
R
F
----
I
-
S
R
G
D
-
V
V
-----
R
A
G
Q
P
A
--
F
------
A
L
V
-
N
P
E
S
F
Y
V
E
V
L
L
E
E
T
-----
K
L
--
K
G
V
--------
K
V
---------------------
G
N
K
A
Y
V
R
L
D
A
Y
-
P
--------
D
I
L
F
E
G
V
V
E
E
I
S
P
-------
V
-------
Q
R
I
P
V
K
I
K
I
T
K
G
--
D
L
S
L
------------
L
R
V
---
G
-------
M
G
G
E
V
E
I
R
R
T
---------------------------------------
17
Fugue
56.61
18%
-101
- C5 -
4LXU
10
?
A:
[1-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
I
K
I
C
I
A
G
K
N
N
I
A
V
N
S
L
Q
F
I
L
K
N
Y
-----
F
E
A
D
Q
-------------
I
--
V
-
V
I
P
N
K
---
N
--------------------
D
K
G
I
D
S
W
Q
K
S
L
L
K
F
A
L
D
N
N
--
I
K
I
-
V
T
L
D
E
I
Y
N
I
E
Q
I
I
F
F
S
-
L
E
F
D
--------------
Q
I
I
K
--
I
E
N
F
-
K
S
D
---
R
L
F
N
I
H
F
S
--------
A
L
-
P
K
YKGV
F
T
S
I
T
P
I
L
N
N
E
L
E
S
G
V
T
L
H
R
I
D
NGIDTGNII
D
Q
H
C
F
P
I
DIND
T
A
R
D
L
Y
F
---------------
N
Y
L
K
Y
G
E
S
I
F
K
K
N
I
-
Q
T
-
I
I
N
N
S
Y
K
D
----
L
K
Q
T
N
I
N
------------------
S
S
Y
F
S
R
K
D
I
NLVHKINF
K
K
----
T
S
--
F
E
I
H
N
Q
I
R
A
F
I
F
Q
E
----
Y
Q
L
P
I
I
N
N
S
K
I
I
K
S
I
L
A
N
E
F
I
-
G
Y
N
V
-
F
E
E
F
EN
Y
F
I
I
S
G
I
D
G
F
------
K
I
I
A
Q
K
L
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
40.73
33%
59
* C6 *
4HVZ
-
BP26_BRUA1
A:
[187-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
D
A
A
G
V
G
--
L
G
R
V
V
E
I
S
E
L
S
R
P
-
P
M
P
M
P
------
I
A
R
G
-
Q
--
F
R
T
M
L
A
A
A
P
D
--
N
S
V
P
-
I
A
A
G
E
N
S
Y
N
V
S
V
N
V
--------
V
F
-
E
I
----
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
39.92
37%
55
- C8 -
3P8C
-
CYFP1_HUMAN
A:
[1032-1063]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
P
R
V
H
V
K
E
G
E
R
--
L
D
A
K
-
M
K
R
L
E
S
K
Y
A
P
L
H
L
V
--------
P
L
-
I
E
----
R
L
G
T
P
Q
Q
I
A
I
A
R
E
G
D
L
L
T
K
E
-----------
R
L
C
C
G
L
S
----
M
F
E
V
I
L
T
---------------
R
---------
I
R
S
F
-
L
D
-
D
P
I
W
R
G
P
L
----
P
S
N
G
V
M
H
------------------
V
D
E
C
V
E
F
H
R
--------
L
W
----
S
A
--
M
Q
F
V
Y
C
I
P
V
G
T
H
E
F
----
T
V
E
Q
C
F
G
D
G
L
H
W
A
G
C
M
I
I
V
L
L
-
G
Q
Q
R
-
R
F
-----
A
V
L
D
F
C
--
Y
------
H
L
L
K
V
Q
K
H
D
G
K
D
E
I
I
K
N
V
-----
P
L
--
K
K
M
--------
V
E
R
I
R
-------
K
F
Q
I
L
N
D
----
E
I
I
T
I
L
D
K
Y
L
K
-
E
------
H
V
R
C
F
Q
P
P
I
H
Q
S
L
--------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
38.60
37%
36
- C8 -
4N78
-
CYFP1_HUMAN
A:
[1032-1063]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
P
R
V
H
V
K
E
G
E
R
--
L
D
A
K
-
M
K
R
L
E
S
K
Y
A
P
L
H
L
V
--------
P
L
-
I
E
----
R
L
G
T
P
Q
Q
I
A
I
A
R
E
G
D
L
L
T
K
E
-----------
R
L
C
C
G
L
S
----
M
F
E
V
I
L
T
---------------
R
---------
I
R
S
F
-
L
D
-
D
P
I
W
R
G
P
L
----
P
S
N
G
V
M
H
------------------
V
D
E
C
V
E
F
H
R
--------
L
W
----
S
A
--
M
Q
F
V
Y
C
I
P
V
G
T
H
E
F
----
T
V
E
Q
C
F
G
D
G
L
H
W
A
G
C
M
I
I
V
L
L
-
G
Q
Q
R
-
R
F
-----
A
V
L
D
F
C
--
Y
------
H
L
L
K
V
Q
K
H
D
G
K
D
E
I
I
K
N
V
-----
P
L
--
K
K
M
--------
V
E
R
I
R
-------
K
F
Q
I
L
N
D
----
E
I
I
T
I
L
D
K
Y
L
K
-
E
------
H
V
R
C
F
Q
P
P
I
H
Q
S
L
--------------------------------------------------------------------------------------------------------------
20
Fugue
36.42
16%
171
- C5 -
1Y66
6
?
A:
[3-52]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
W
S
E
----
E
V
E
R
K
L
K
---------------
E
---------
F
V
R
R
-
H
Q
E
I
T
Q
E
T
L
H
E
----
Y
A
Q
K
L
G
L
------------------
N
Q
Q
A
I
E
Q
F
F
--------
R
E
----
F
E
--
Q
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
33.36
8%
20
- C5 -
4LL7
1
SHE3_YEAST
A:
[2-95]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
R
V
I
E
S
L
H
D
-
Q
--
I
D
M
L
T
K
T
N
L
Q
--
L
T
T
Q
-
S
Q
N
L
L
S
K
L
E
L
A
Q
S
K
--------
E
S
-
K
L
----
L
E
N
L
N
L
L
K
N
E
N
E
N
L
N
S
I
F
E
R
-----------
K
N
K
K
L
K
E
----
L
E
K
D
Y
S
E
---------------
L
---------
S
N
R
Y
-
N
E
-
Q
K
E
K
M
D
Q
L
----
S
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
27.52
67%
271
* C7 *
2MDW
-
?
A:
[2-27]
--------------------------------------------------------------------------------------------
L
-------
P
P
G
W
E
K
R
C
---
F
Y
F
N
A
S
---------
R
A
R
I
I
L
------
T
T
H
G
K
R
A
R
Q
G
L
F
E
R
A
R
P
S
D
A
--
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
27.18
29%
829
- C7 -
1SLU
-
?
A:
[112-125]
-----------------------------------------------------------------------------
K
L
P
-------
I
V
V
-
Y
T
-------
P
D
N
V
D
V
K
Y
---
R
V
W
K
A
E
---------
E
K
I
D
N
A
------
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
26.25
12%
-18
- C8 -
3WU2
-
PSBT_THEVL
T:
[6-29]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
T
Y
V
F
I
F
A
C
I
I
A
L
F
F
F
A
I
F
F
R
E
P
P
R
I
T
A
N
L
W
E
R
F
C
N
W
V
T
S
T
D
N
R
L
-----
Y
V
G
W
F
-------------
G
--
V
-
I
M
I
P
T
---
L
L
-------
A
A
T
I
C
-
F
V
I
A
F
I
A
A
P
P
V
D
I
D
G
I
R
E
P
V
S
G
S
L
L
--
Y
G
N
N
I
I
T
G
A
V
V
P
S
S
N
A
I
G
L
H
-
F
Y
P
I
W
E
A
A
-
S
--
L
D
E
W
L
Y
N
G
G
P
--
Y
Q
L
I
-
I
F
H
F
L
L
G
A
S
C
Y
M
G
R
--------
Q
W
-
E
L
----
S
Y
R
L
G
M
R
P
W
I
C
V
A
Y
S
A
P
L
A
S
-----------
A
F
A
V
F
L
I
----
Y
P
I
G
Q
G
S
---------------
F
---------
S
D
G
M
-
P
L
-
G
I
S
G
T
F
N
F
----
M
I
V
F
Q
A
E
------------------
H
N
I
L
M
H
P
F
H
--------
Q
L
----
G
V
--
A
G
V
F
G
G
A
L
F
C
A
M
H
G
----
S
L
V
T
S
S
L
I
R
E
T
T
E
T
E
S
A
N
Y
G
Y
-
K
F
G
Q
-
E
E
-----
E
T
Y
N
I
V
--
A
------
A
H
G
Y
F
G
R
L
I
F
Q
Y
A
S
F
N
N
S
-----
R
S
--
L
H
F
--------
F
L
A
A
W
-------
P
V
V
G
V
W
F
----
A
A
L
G
I
S
T
M
A
F
N
-
L
------
N
G
F
N
F
N
H
S
V
I
D
A
K
G
N
V
I
N
T
W
A
D
I
-------
I
N
R
A
N
L
G
M
E
V
M
H
--
E
R
N
A
---
H
N
F
P
L
D
L
A
----------------------------------------------------------------
5
HHSearch
25.67
10%
301
- C8 -
3O7Q
1
FUCP_ECOLI
A:
[153-173]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
L
N
L
A
Q
T
F
N
S
F
---
G
A
I
I
A
V
V
F
G
------------------------------------------------
4
HHSearch
25.51
27%
898
- C6 -
2RFE
-
ERRFI_HUMAN
E:
[18-32]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
G
V
M
P
P
T
Q
S
F
A
P
D
-
P
K
Y
V
-
S
S
-----
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
22.03
57%
2054
- C1 -
3LE4
-
DGCR8_HUMAN
A:
[302-308]
-------------------------------------------------------------------------------------------
P
L
-------
P
D
G
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
13.83
14%
611
* C8 *
1OEF
-
A:
[265-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
L
V
---
E
D
-------
M
Q
R
Q
W
-
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------