@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SC5A6_HUMAN: (2015-12-11 )
MSVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEYPMSIQQAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFPEFSEARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGLLAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVATVTTLMPLTTFSKPTGLQRFYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSCQKRLHCRSYGQDHLDTGLFPEKPRNGVLGDSRDKEAMALDGTAYQGSSSTCILQETSL
Atome Classification :
(20 SA)
----------------.......--..10...-.....20........30........40........50........60........70........80....-....90........100.......110.......120-.........130...-....140------........150....-....----160.......170..-----.....180---------......-.190.......200.......210.-----......220..--..-..--.-230.....-----..----------------240...------....250-...-----....260.-...---..-..270........280.--------.--..----...290...--....300.......310--.....-...320..------......330-----.......340........-350.---.......360.....-..370.......380....-.-..390.......---400.......410...-....420.......430...-----------------....440------------------------------.......----450---------.-------..----....460...-----.....470.......-480.......490.......500........510--........520.......530.......540.......550.......560.......570..---.....580.......590.......600-.......610.......620.......630...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MSVGVST--SAPLSPT-SGTSV
G
M
S
T
F
S
I
M
D
Y
V
V
F
V
L
L
L
V
L
S
L
A
I
G
L
Y
H
A
C
R
GW
G
R
H
T
V
G
E
L
L
M
ADRKMG
C
L
P
V
A
L
S
L
L
A
T
F
Q
S
A
V
A
I-LGV
P
S
E
I
Y
R
F
GT
Q
Y
W
F
L
G
C
C
Y
F
L
G
L
L
I
P
A
H
I
F
I
P
V
---
F
Y
R
L
H
L
T
S
A
Y
E
Y
L
E
L
-
R
FN
K
T
V
-------
R
V
C
G
T
V
T
F
I
-
F
Q
M
V
I
-
Y
M
G
V
----
V
L
YAP
S
L
A
L
N
AVT
G
F
-----
D
L
W
L
S
V
L
A
---------
L
G
I
V
C
T
-
V
Y
T
A
L
G
G
L
K
A
V
I
W
T
D
V
F
Q
T
L
V
M
F
L
G
-----
Q
L
A
V
I
I
V
GSAK--VG-GL--
G
-
R
V
W
A
V
A
SQ-----HG----------------RISGFE------LDPDPFV-
R
H
T
-----
F
W
T
L
A
F
-
G
-
G
V
F
---
M
M
-
L
S
LY-GV
N
Q
A
Q
V
Q
R
Y
L
S
--------S--RT----
E
K
A
A
V
L
S
C
Y
--AVF
P
F
Q
Q
V
S
L
C
V
G
C
L
I
---
G
L
V
M
F
-
A
Y
Y
Q
E-YP------
M
S
I
Q
Q
AQAA-----P
D
Q
F
V
L
Y
F
V
-
M
D
L
L
K
GLP-G-L
P
---
G
L
F
I
A
C
L
FSG
S
L
S
T
I
-
S
S
A
F
N
S
L
A
T
V
T
M
E
D
L
I
R
P
W-F-P
E
F
S
E
A
R
A
I
M
L
S---R
G
L
A
F
G
Y
G
L
L
C
L
G
M
A
Y
-
I
S
SQ
M
G
P
V
L
Q
A
A
I
S
I
F
GMVG-----------------
G
P
L
L
G
L
F
------------------------------
C
L
G
M
FFP----CAN---------P-------
P
G
----
A
V
V
G
L
-
L
A
G
L
-----
V
M
A
F
W
I
G
I
G
S
I
V
T
S
M-GSSMPPSPSNGSSFSLPT
N
L
T
-
V
A
T
V
T
T
L
MPLT---TFSK
P
T
G
L
Q
R
F
Y
S
L
S
Y
L
W
YSAHN
S
T
T
V
I
V
V
G
L
I
V
S
L
L
TGRMRGRSLN
P
A
T
I
Y
P
V
L
P
K
L
L
S
LL
P
---
L
S
C
Q
K
R
L
H
C
R
SY
G
Q
D
HLDTGLFPEKPRN-GVLGDSRDK
E
A
M
ALDGTAYQGSS
S
T
C
I
L
QETSL
56
HHSearch
93.27
23%
-156
- C2 -
2XQ2
3
SGLT_VIBPH
A:
[9-505]
-------------------------------------------
S
F
I
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
------------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
-
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
-
R
F
N
K
K
L
-------
K
T
I
L
A
V
F
W
I
S
L
Y
I
F
V
-
N
L
T
S
----
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
---------
L
A
L
F
A
L
-
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
-----
G
F
M
T
T
Y
M
A
V
S
F
--
I
G
-
G
T
--
D
-
G
W
F
A
G
V
S
K
M
V
D
A
A
P
G
----------------
H
F
E
M
I
L
------
D
Q
S
N
P
Q
Y
M
N
L
P
-----
G
I
A
V
L
I
G
G
-
L
W
V
---
A
N
-
L
Y
Y
W
-
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
--
K
S
----
V
S
E
A
Q
K
G
I
V
--
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
---
G
I
A
A
Y
-
V
I
T
S
D
-
P
Q
L
M
A
S
L
G--
N
L
P
S
A
A
N
-----
A
D
K
A
Y
P
W
L
T
--
Q
F
L
P
--
V
-
G
-
V
K
---
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
I
S
-
P
D
S
G
D
H
K
L
V
N
V
G
---
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
-
M
L
G
G
I
G
Q
C
F
Q
Y
I
Q
E
Y
T
G
L
V
S
-----------------
P
G
I
L
A
V
F
------------------------------
L
L
G
L
F
W
K
----
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
-
V
A
S
I
-----
P
F
A
L
F
L
K
F
M
P
L
-----------------------------------------------------
S
M
P
F
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
---
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
-
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
--------------
1
PsiBlast_PDB
86.34
24%
-159
- C2 -
2XQ2
3
SGLT_VIBPH
A:
[9-470]
-------------------------------------------
S
F
I
D
I
M
V
F
A
I
Y
V
A
I
I
I
G
V
G
L
W
V
S
------------------
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
-
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
-
R
F
N
K
K
L
-------
K
---
T
I
L
A
V
-
F
W
I
S
L
-
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
---------
L
A
L
F
A
L
-
V
Y
S
I
Y
G
G
---
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
-
G
V
--
S
-
K
M
V
D
A
A
P
G
-----
H
F
----------------
E
M
I
L
D
Q
------
S
N
P
Q
-
Y
M
-
N
L
P
-----
G
I
A
V
L
I
-
G
-
G
L
W
---
V
A
N
L
Y
Y
W
-
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
--
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
A
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
-
A
S
L
G
------------
N
L
P
S
A
A
N
-----
A
D
K
A
Y
P
W
-----
L
T
Q
F
L
P
V
G
-
V
K
---
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
S
P
D
S
G
D
H
K
L
V
N
V
G
---
R
T
A
A
V
V
A
L
I
I
A
A
L
I
A
P
-
M
L
G
G
I
G
Q
C
F
Q
Y
I
Q
E
Y
T
G
L
V
S
-----------------
P
G
I
L
A
V
F
------------------------------
L
L
G
L
F
W
K
----
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
-
V
A
S
I
-----
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
-
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
-
T
S
I
N
D
D
D
P
K
G
I
---
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
N
A
D
A
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
K
------------------------------------------------------------------
68
Fugue
83.66
19%
-105
- C2 -
4RKN
10
MCCA_WOLSU
A:
[43-702]
----------------
M
Q
M
T
K
E
A
--
R
E
I
I
A
H
P
-
K
G
T
K
E
S
R
G
V
I
S
L
Q
D
Y
I
V
E
E
Q
A
M
Y
D
W
L
F
K
N
-
H
P
I
F
T
K
Y
G
G
K
T
V
G
K
L
V
V
K
D
R
G
E
E
W
I
E
E
G
R
G
N
D
F
S
K
A
S
K
R
S
G
G
E
G
F
S
S
M
M
Y
R
V
A
R
N
S
---------
T
L
Q
Y
P
N
K
F
I
G
P
E
---
K
C
G
E
C
H
P
A
Q
Y
E
T
W
S
R
S
R
H
A
T
T
I
-------
R
F
P
G
E
H
P
E
V
-
N
N
K
------------
L
N
D
P
V
F
D
K
D
T
A
------------
S
I
L
P
---------
Q
G
I
T
P
D
V
V
Y
C
T
V
G
H
I
R
T
-----
K
F
G
F
F
D
A
W
L
L
-----
R
G
T
Y
H
V
E
G
G
L
L
--
K
N
-
G
T
--
G
-
Q
I
V
A
G
G
N
Q
-----
W
Q
----------------
R
T
W
A
L
N
------
L
S
P
E
V
A
K
-
K
I
K
-----
K
W
V
P
D
F
-----
P
---
V
T
-
L
E
E
Y
-
G
D
N
G
G
Y
V
R
G
L
A
S
--------
Y
--
A
A
----
K
Y
K
K
S
M
S
F
Q
--
A
-----
S
T
S
Y
C
E
V
C
H
P
---
W
K
F
D
F
-
K
N
E
S
E
-
F
Y
------
A
A
L
G
N
A
K
E
L
-----
Q
K
H
T
I
S
K
G
V
S
C
E
E
C
H
G
A
G
-
G
-
H
----------
L
E
G
G
S
G
L
L
I
-
S
N
C
E
R
C
H
Q
R
F
S
Y
S
P
D
L
M
R
N
-
N
-
P
L
N
A
G
K
P
D
L
A
L
S
SKF
K
S
M
G
P
G
C
G
S
E
G
S
Q
T
Y
F
T
A
H
Y
E
K
G
M
R
C
A
T
C
H
D
P
H
D
V
T
G
N
V
T
G
E
KGIKGVSYNSEQ
G
Y
L
S
S
L
Y
S
K
P
KLKKE
C
T
D
C
H
K
E
Q
A
Y
I
Q
S
KADTHSKNS
C
A
S
C
H
M
P
FMMS
C
E
N
---------
F
-------
Y
A
----
I
Q
F
Q
D
-
Q
A
G
F
DTQRR
A
H
I
W
K
I
D
V
D
P
A
R
K
S
L
V
A
G
S
T
S
K
D
P
R
D
G
K
D
W
H
F
E
R
N
E
E
-
G
R
N
F
V
D
L
M
W
A
C
A
R
T
T
W
A
D
K
D
Q
A
E
A
K
G
C
H
S
P
V
V
S
E
L
K
E
T
L
H
F
K
D
Q
K
Q
V
Y
N
E
V
M
G
W
Q
T
P
V
K
D
K
F
T
Q
V
K
V
G
I
Q
G
L
Y
S
L
L
E
VKK
L
A
P
S
D
K
T
R
V
Y
E
L
I
E
K
A
Q
D
T
V
D
L
I
E
K
D
G
S
W
G
M
H
G
F
K
Y
T
K
Q
R
L
D
---
A
A
V
E
Y
I
N
E
A
Q
R
I
M
K
K
S
L
65
Fugue
72.13
21%
-95
- C2 -
3DH4
1
?
A:
[52-518]
--------------------------------------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
-
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
-
R
F
N
K
K
L
-------
K
T
I
L
A
V
F
W
I
-
S
L
Y
I
F
V
N
L
T
S
----
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
---------
L
A
L
F
A
L
-
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
-----
G
F
M
T
T
Y
M
A
V
S
F
--
I
G
-
G
T
--
D
-
G
W
F
A
G
V
S
K
-----
M
V
----------------
D
A
A
P
G
H
FEMILD
Q
S
N
P
Q
Y
M
-
N
L
P
-----
G
I
A
V
L
I
-
G
-
G
L
W
---
V
A
-
N
L
Y
Y
W
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
--
K
S
----
V
S
E
A
Q
K
G
I
V
--
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
---
G
I
A
A
Y
-
V
I
T
S
D
-
P
Q
------
L
M
A
S
L
G
D
I
A
ATNLP
S
A
A
N
A
D
K
A
Y
-
P
W
L
T
Q
F
L
P
V
G
-
V
K
---
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
S
P
D
S
G
D
H
K
L
V
N
V
G
---
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
-
M
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
-----------------
P
G
I
L
A
V
F
------------------------------
L
L
G
L
F
W
K
----
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
-
V
A
S
I
-----
P
F
A
L
F
L
K
F
-----------------
M
P
L
S
M
P
F
M
D
Q
M
L
-
Y
T
L
L
F
T
M
V
V
I
A
---
F
T
S
L
S
T
S
I
N
D
D
D
P
K
G
I
S
V
T
S
S
M
F
V
T
D
---------------
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
---
V
L
Y
K
----------------------------------------------------------
67
Fugue
72.00
18%
-137
- C2 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
--------------------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
-
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
--------
G
R
R
D
S
L
K
I
A
A
V
L
---
F
F
I
S
G
V
G
S
A
W
--
P
E
L
-
G
F
T
-
S
I
-------
N
P
D
N
T
V
P
V
Y
-
L
A
G
-------------
Y
V
P
E
F
V
I
Y
R
I
I
G
G
-----
I
G
V
G
L
A
S
M
---------
L
S
P
M
Y
I
-
A
E
L
A
P
A
H
I
R
G
K
L
V
S
--
F
N
Q
F
A
I
I
F
G
-----
Q
L
L
V
Y
C
V
N
Y
F
I
--
A
R
-
S
G
--
D
-
A
S
W
L
N
T
D
-----------------------------------------
G
W
-
R
Y
M
-----
F
A
S
E
C
I
-
P
-
A
L
L
---
F
L
-
M
L
L
Y
-
T
V
P
E
S
--
P
R
W
L
M
--------
T
--
L
A
----
T
Q
A
V
Q
E
I
K
H
--
S
L
D
--
R
L
L
M
F
G
V
G
V
I
V
---
I
G
V
M
L
-
S
I
F
Q
Q
-
F
V
------
G
I
--------------
N
V
V
L
Y
Y
A
-
P
E
V
F
K
T
L
G
----
A
---
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
-
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
-----------
K
P
L
Q
I
I
---
G
A
L
G
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
T
-------------------------------------------------------------------------------------
Q
---------
A
-------
P
G
----
I
V
A
L
L
S
M
L
F
Y
-----
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
-
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
---
M
M
D
K
N
S
W
L
V
A
H
F
---------
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
--------------------------------------------
F
V
P
E
T
K
G
-
K
T
L
------------------------------
2
PsiBlast_PDB
66.41
24%
-101
- C2 -
3DH4
1
?
A:
[52-441]
--------------------------------------------------------------------------------
A
G
K
S
L
P
W
W
A
V
G
A
S
L
I
A
A
N
I
S
A
E
Q
F
-
I
G
M
S
G
S
G
Y
S
I
G
L
A
I
A
S
Y
E
W
M
S
A
I
T
L
I
I
V
G
K
Y
F
L
P
I
---
F
I
E
K
G
I
Y
T
I
P
E
F
V
E
K
-
R
F
N
K
K
L
-------
K
---
T
I
L
A
V
-
F
W
I
S
L
-
Y
I
F
V
N
L
T
S
V
L
Y
L
G
G
L
A
L
E
T
I
L
G
I
-----
P
L
M
Y
S
I
L
G
---------
L
A
L
F
A
L
-
V
Y
S
I
------
V
V
W
T
D
V
I
Q
V
F
F
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
-
G
V
--
S
-
K
M
V
D
A
A
P
G
-----
H
F
----------------
E
M
I
L
D
Q
------
S
N
P
Q
-
Y
M
-
N
L
P
-----
G
I
A
V
L
I
-
G
-
G
L
W
---
V
A
N
L
Y
Y
W
-
G
F
N
Q
Y
I
I
Q
R
T
L
A
--------
A
--
K
S
V
S
E
A
Q
K
G
I
V
F
A
A
F
L
K
L
I
V
P
F
L
V
V
L
P
G
I
A
A
Y
V
I
T
S
D
P
Q
L
M
-
A
S
L
G
D
-
I
A
------
A
T
N
L
P
S
A
A
N
-----
A
D
K
A
Y
P
W
-----
L
T
Q
F
L
P
V
G
-
V
K
---
G
V
V
F
A
A
L
A
A
A
I
V
S
S
L
-
A
S
M
L
N
S
T
A
T
I
F
T
M
D
I
Y
K
E
Y
-
I
S
P
D
S
G
D
H
K
L
V
N
V
G
---
R
T
A
A
V
V
A
L
I
I
A
C
L
I
A
P
-
M
L
G
G
I
G
Q
A
F
Q
Y
I
Q
E
Y
T
G
L
V
S
-----------------
P
G
I
L
A
V
F
------------------------------
L
L
G
L
F
W
K
----
K
T
T
---------
S
-------
K
G
----
A
I
I
G
V
-
V
A
S
I
-----
P
F
A
L
F
L
K
F
M
P
L
S
M
P
F
-
M
D
Q
M
L
Y
T
L
L
F
T
M
V
V
I
A
F
T
S
L
S
-
T
S
I
N
D
D
D
P
K
G
I
---
S
V
T
S
S
M
F
V
T
D
R
S
F
N
I
A
A
Y
G
I
M
I
V
L
A
V
L
Y
T
L
F
W
V
L
Y
K
--------------------------------------------------------------------------------------------
72
Fugue
66.13
11%
-123
- C2 -
2A65
6
?
A:
[5-515]
REHWAT
R
L
G
L
I
L
A
M
A
G
N
A
V
G
L
G
N
FL
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
-------------------------
H
G
T
T
P
A
I
F
Y
L
-
L
W
R
N
R
F
A
K
I
L
G
V
------------
F
G
L
W
I
P
L
V
V
A
I
---
Y
Y
V
Y
I
E
S
W
T
L
G
F
A
I
K
-
F
L
V
G
L
V
P
E
P
PPTD
P
D
S
I
L
R
P
F
K
-
E
F
L
Y
S
-
Y
I
G
V
----
P
K
G
D
E
P
I
L
K
P
S
L
F
A
Y
-----
I
V
F
L
I
T
M
F
---------
I
N
V
S
I
L
-
I
R
G
I
S
K
G
I
E
R
F
A
K
I
A
M
P
T
L
F
I
L
A
V
F
-----
L
V
I
R
V
F
L
L
E
T
P
--
N
G
-
T
A
A
D
G
-
L
N
F
L
W
T
P
D
-----
F
E
----------------
K
L
K
D
P
G
------
V
W
I
A
-
A
V
-
G
Q
I
-----
F
F
T
L
S
L
-
G
F
G
A
I
---
I
T
-
Y
A
S
Y
-
V
R
K
D
Q
D
I
V
L
S
G
L
--------
T
--
A
A
----
T
L
N
E
K
A
E
V
I
--
L
-----------
G
G
S
I
---
S
I
P
A
A
-
V
A
F
F
G
-
V
A
------
N
A
V
A
I
A
K
A
G
-----
A
F
N
L
G
F
I
T
L
-
P
A
I
F
S
Q
T
A
-
G
-
G
T
F
L
G
F
L
W
F
F
L
L
F
F
A
G
L
T
S
S
-
I
A
I
M
Q
P
M
I
A
F
L
E
D
E
------
L
-
K
L
S
R
K
H
A
V
L
W
T
A
---
A
I
V
F
F
S
A
H
L
V
M
F
L
----------
N
K
S
L
D
E
M
D
F
W
A
---------------------------------------------------------------------
G
T
---------
I
-------
G
V
----
V
F
F
G
L
-
T
E
L
I
-----
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
-
N
R
G
G
I
I
K
V
P
------------------------------------
R
I
Y
Y
Y
V
M
R
Y
I
T
P
A
F
L
A
V
L
L
V
V
W
A
R
E
Y
I
P
K
I
M
E
E
T
H
W
T
V
W
I
T
R
F
Y
I
I
G
L
F
L
F
L
T
F
---
L
V
F
L
A
E
R
R
R
N
H
E
S
A
G
T
----------------------------------------------
58
HHSearch
63.25
17%
-151
- C2 -
2JLN
-
?
A:
[22-424]
-------------------------------------------------------------------------------
Y
A
E
R
S
V
G
P
F
S
L
A
A
I
W
F
A
M
A
I
Q
V
A
I
F
-
I
A
A
G
Q
--
M
T
S
S
F
Q
V
W
Q
V
I
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
I
R
W
G
-
I
N
F
T
V
A
A
R
M
-
P
F
G
I
R
G
-------
S
L
I
P
I
T
L
K
A
-
L
L
S
L
F
-
W
F
G
F
----
Q
T
W
L
G
A
L
A
L
D
E
I
T
R
L
L
TGFT
N
L
P
L
W
I
V
I
---------
F
G
A
I
Q
V
-
V
T
T
-
F
Y
G
I
T
F
I
R
W
M
N
V
F
A
S
P
V
L
L
A
M
-----
G
V
Y
M
V
Y
L
M
L
D
G
--
A
D
V
S
L
--
G
-
E
V
M
S
M
G
G
E
--------------------------------------
N
P
---
G
M
P
-----
F
S
-
T
A
I
-
M
-
I
F
V
---
G
G
-
W
I
A
V
-
V
V
S
I
H
D
I
V
K
E
C
K
VDPNAS
R
E
G
--
Q
T
----
K
A
D
A
R
Y
A
T
A
---
Q
W
L
G
M
V
P
A
S
I
I
F
G
F
I
---
G
A
A
S
M
-
V
L
V
G
E
----------------
W
N
-----
P
V
I
A
I
T
E
V
V
-
G
G
-
V
S
--
I
-
P
-
M
A
---
I
L
F
Q
V
F
V
L
L
A
T
W
S
T
N
P
A
A
N
L
L
S
P
A
Y
T
L
C
S
-
T
F
P
R
V
-
F
----------
T
F
K
---
T
G
-
V
I
V
S
A
V
V
G
L
L
M
M
P
-
W
--
Q
F
A
G
V
L
N
T
F
L
N
L
L
A
S
A
L
-----------------
G
P
L
A
G
I
M
------------------------------
I
S
D
Y
F
L
V
----
R
R
R
RIS
L
H
D
L
Y
R
T
KGIYTYW
R
G
VN
W
V
A
L
A
V
Y
-
A
V
A
L
-----
A
V
S
F
L
T
P
D
L
M
F
V
T
G
L
-
I
A
A
L
L
L
H
I
P
A
M
R
W
V
A
K
T
F
P
L
F
-
S
E
A
E
S
R
N
E
D
Y
L
---
R
P
I
G
P
---------------------------------------------------------------------------------------------------------------------------
69
Fugue
48.30
20%
-147
- C1 -
3SPE
-
?
A:
[7-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
N
P
S
R
L
-
I
V
A
I
----
E
I
V
E
D
E
I
P
L
T
K
V
D
G
L
-----
K
A
R
I
I
L
I
E
D
NTSEVGTQ
R
V
L
P
G
T
-
L
V
S
D
K
D
G
S
Q
S
L
V
Y
P
-
L
F
E
A
P
V
S
F
F
G
-----
K
L
G
D
S
------------
N
--
G
M
R
V
W
S
T
T
T
A
-----
D
I
EEFD
E
A
A
M
A
K
F
K
T
R
Q
F
R
I
Q
L
I
E
------
K
P
E
S
P
V
I
-
V
K
T
ADQQD
Y
L
N
I
T
F
-
D
K
G
V
Y
SDM
Y
N
-
A
D
L
Y
--
V
G
D
V
L
V
D
S
Y
S
D
--------
D
GV
V
S
----
G
L
S
P
L
Y
S
-------
P
F
S
Q
F
Y
V
Y
H
E
N
-
I
---
D
L
V
R
Q
M
I
Y
D
T
E
M
R
V
------
N
P
A
A
A
A
H
T
T
-----
A
P
G
E
I
D
F
L
T
-
F
L
A
V
D
G
D
P
---
Y
Q
---
G
I
Q
V
L
G
P
L
D
G
G
I
-
T
L
-
G
K
D
G
N
I
Y
A
S
G
G
T
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
47.85
35%
-88
- C2 -
2QDG
1
?
A:
[255-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
D
A
S
S
------------------------------
S
S
L
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
47.39
35%
-84
- C2 -
2QAP
-
?
A:
[255-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
47.27
35%
-81
- C2 -
2QDG
1
?
C:
[255-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_CBE
46.55
35%
-91
- C2 -
2QDH
1
?
D:
[255-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
46.37
35%
-83
- C2 -
1EPX
-
?
A:
[235-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
46.11
35%
-86
- C2 -
2QDG
1
?
D:
[255-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_CBE
46.06
35%
-81
- C2 -
2QDH
1
?
C:
[255-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
45.76
35%
-83
- C2 -
2QDH
1
?
A:
[255-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
D
A
S
S
------------------------------
S
S
L
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
45.65
35%
-87
* C2 *
2QDH
1
?
B:
[255-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
D
A
S
S
------------------------------
S
S
L
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
43.45
35%
-89
- C2 -
2QDG
1
?
B:
[255-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
L
---
K
P
N
M
V
-
V
------
P
------
G
A
E
S
G
K
T
A
A
-----
P
E
Q
V
A
H
Y
T
V
-
M
T
L
A
R
T
M
P
-
A
M
L
P
---
G
V
M
---
F
L
S
G
G
L
S
E
V
-
Q
-
A
S
E
Y
L
N
A
I
N
N
S
P
L
P
R
P
Y
-
F
-
L
S
F
S
Y
A
R
A
L
Q
S
S
---
A
L
K
A
W
G
G
K
E
S
G
L
A
A
G
R
-
R
A
F
L
H
R
A
R
M
N
S
M
A
Q
L
G
K
Y
K
R
-----------------
S
D
D
D
A
S
S
------------------------------
S
S
L
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
39.59
31%
-18
- C2 -
1FDJ
1
ALDOB_RABIT
A:
[245-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Q
V
A
M
A
T
V
-
T
A
L
H
R
T
V
P
-
A
A
V
P
---
G
I
---
C
F
L
S
G
G
M
S
E
E
-
D
A
T
L
N
-
L
N
A
I
N
L
C
P
L
P
K
P
W
-
K
-
L
S
F
S
Y
G
R
A
L
Q
A
S
---
A
L
A
A
W
G
G
K
A
E
N
K
K
A
T
Q
-
E
A
F
M
K
R
A
V
V
N
C
Q
A
A
K
G
Q
Y
V
H
-----------------
T
G
S
S
G
A
A
------------------------------
S
T
Q
S
L
F
T
----
A
S
Y
---------
T
-------
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------