@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MOT3_HUMAN: (2015-12-08 )
MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------.........-10........20..-......30.....---...40.......-.-50..-----......60........70...---.....80-----........90---........100...---.----..-.110-.---.----------------.......120....----...130.....------.---.-140......-.150---..--.......--160.......--------------------------170.......180.--------------------......190------...-.....200.......210.......220......--.230.......240.--------------......250.......260.......270.......280--.------........---290.......300.......310.......320..-------.....330-...--...-...--340-.......350.......360....---------------...370..--....----------------.380..-.....390.-.----.....400.......410.......420.......430.-------......440.......------450.......460.......470...---------....480.......490.......500..--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------MGAGGPRRG-EGPPDGG
W
G
W
V
V
L
G
-
A
C
F
V
V
T
G
F
AYGF
P
---
K
A
V
S
V
F
F
R
A
L
M
R
-
D
-FDAG-----YS
D
T
A
W
V
S
S
I
M
L
A
M
L
YGTG
P
V
---
S
S
I
L
V
T
R-----FGC
R
P
V
M
L
A
G
---
G
L
L
A
S
A
G
M
I
L
A
S
F
A
---
T
----
R
L
-
L
E
---
L
---
Y
----------------
L
T
A
G
V
L
T
GL
G
L
A
L
N----FQP
S
L
I
M
L
G
L
Y
------
F
---
E
-RRR
P
L
ANGL-AA-----AG--S
P
V
F
L
S
A
--
L
S
P
L
G
Q
Q
L
L
E
--------------------------
R
FGWR
G
G
F
L
L
L
G
G
L
--------------------
L
L
H
C
CACG-------AVM-RPPPGPGPRPRRDSAGDRAGDAPGEAEADGA
G
L
Q
--LREASPRV
R
P
R
R
R
L
L
--------------
D
L
A
VCTDR
A
F
A
V
Y
A
V
T
K
F
L
M
A
L
G
L
F
V
P
A
I
L
L
V
NYAKD----A------GVPD
T
D
A
A
---
F
L
L
S
I
V
G
F
V
D
I
VARP
A
C
G
A
L
A
G
L
A
R
LRPH
V
P
Y
L
F
S
-------
L
A
L
L
AN---
G
L
T
--
D
L
S
-
S
A
R
--
A
R
S
-
Y
G
A
L
V
A
F
C
V
A
F
G
L
S
Y
G
M
V
G
A
L
Q
F
E
---------------
V
L
M
A
A
VGA--PRF
P
----------------
S
A
L
G
L
V
-
L
L
V
E
A
A
A
V
L
-I----GPPSA
G
R
L
V
D
V
LKN
Y
E
I
I
F
Y
LAGS
E
V
A
L
A
G
V
F
M
A
V
A
T
N
C
-------
C
L
R
C
A
KAAPSGPGTEG------GASDTEDAEAEGDSEPL
P
V
V
AEEPG
N
---------
L
E
A
L
E
V
L
SARGEPTEPEIEARPRLAAESV--
18
Fugue
94.08
18%
-97
- C3 -
4IKW
13
?
A:
[3-494]
-----------------------------------------------------------------------------------------------------SID
K
Q
Q
I
A
A
S
V
P
Q
R
G
F
F
G
H
P
K
---
G
L
F
T
L
F
-
F
T
E
F
W
E
R
F
S
Y
Y
G
M
---
R
A
I
L
V
Y
Y
--
M
Y
Y
-
E
-
V
S
K
G
GLGLD
E
H
L
A
L
A
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
---
G
G
W
L
A
D
R
V----
F
G
T
S
R
A
V
F
Y
G
---
G
L
L
I
M
A
G
H
I
A
L
A
I
P
---
G
----
G
V
-
A
A
---
L
---
F
----------------
V
S
M
A
L
I
V
L
G
T
G
L
L
K
----
P
N
V
S
S
I
V
G
D
M
Y
------
K
PGD
D
-
R
R
D
A
G
F
S
I
F
-
Y
M
-----
G
I
--
N
L
G
A
F
L
A
--
P
L
V
V
G
T
A
G
M
K
--------------------------
Y
N
F
H
L
G
F
G
L
A
A
V
G
M
--------------------
F
L
G
L
V
V
F
V
-------
A
T
R
-
K
K
N
L
G
L
--------
A
G
T
Y
V
P
N
P
L
T
P
A
E
K
K
K
A
A
A
I
--
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
--------------
I
P
N
----
G
W
F
T
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
R
S
-------------
P
K
T
T
A
E
---
E
R
S
R
V
I
A
Y
I
P
L
F
V
--
A
S
A
M
F
W
A
I
Q
E
Q
G
S
---------------
T
I
L
A
N
---
Y
A
D
--
K
R
T
-
Q
L
D
--
V
A
G
-
I
H
L
S
P
A
W
F
Q
S
L
N
P
L
F
I
I
I
L
A
P
V
F
A
---------------
W
M
W
V
K
L
G
K
RQ
P
T
I
P
----------------
Q
K
F
A
L
G
-
L
L
F
A
G
L
S
F
I
-
V
I
L
V
P
G
H
L
S
G
G
G
L
V
H
P
I
W
L
V
L
S
Y
F
I
V
V
L
G
E
L
C
L
S
P
V
G
L
S
A
T
T
K
L
-------------
A
P
A
A
F
S
A
Q
T
M
------
S
L
W
F
L
S
N
A
A
A
Q
A
I
N
A
Q
L
V
R
F
Y
T
P
E
N
E
---------
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
L
A
I
A
P
R
I
G
R
L
M
KG
25
Fugue
89.16
18%
-110
- C3 -
3WDO
-
?
A:
[1-453]
---------------------------------------------------------------------------------------------------------------------
D
Y
K
M
T
P
G
E
R
R
A
T
W
G
-
L
G
T
V
F
S
L
R
M
L
G
M
F
---
M
V
L
P
V
L
T
T
Y
G
M
A
-
L
-
Q
G
A
S
-----
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
---
F
G
L
L
S
D
R
-----
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
L
S
---
D
----
S
I
-
W
G
---
I
---
I
----------------
L
-
G
R
A
L
Q
G
S
G
-
A
I
A
----
A
A
V
M
A
L
L
S
D
L
T
------
R
---
E
-
Q
N
R
T
K
A
M
A
F
-
I
G
-----
V
S
--
F
G
I
T
F
A
I
--
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
L
H
A
L
F
W
M
I
A
I
L
--------------------
A
T
T
G
I
A
L
T
-------
I
W
V
-
V
P
N
S
S
T
H
V
L
N
R
E
S
G
-------------------
M
--
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
--------------
K
L
N
------
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
---------
A
------
G
F
P
---
A
A
---
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
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V
K
R
K
M
K
Q
V
F
V
-------
F
C
V
G
L
I
---
V
V
A
--
E
I
V
-
L
W
N
--
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
---------------
L
I
S
K
E
S
P
A
--
G
Y
K
G
----------------
T
A
M
G
V
Y
-
S
T
S
Q
F
L
G
V
A
-
I
----
G
G
-
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
---
A
M
L
A
A
V
W
L
A
V
A
S
T
------------
M
K
E
P
P
Y
V
S
S
L
R
I
EIPADI
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
---------
S
A
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
-------
28
HHSearch
69.36
14%
-122
- C3 -
3WDO
-
?
A:
[25-382]
-----------------------------------------------------------------------------------------------------------------------------------------------
G
M
---
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
A
S
-----
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
---
F
G
L
L
S
D
R
-----
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
L
S
---
D
----
S
I
-
W
G
---
I
---
I
----------------
L
G
-
R
A
L
Q
G
S
G
A
--
I
----
A
A
A
V
M
A
L
L
S
D
L
------
T
---
R
E
Q
N
R
T
K
A
M
A
F
-
I
G
-----
V
S
--
F
G
I
T
F
A
I
--
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
G
L
H
A
L
F
W
M
I
A
I
L
--------------------
A
T
T
G
I
A
L
T
-------
I
W
V
-
V
P
N
S
S
T
H
V
L
N
R
E
--
S
------------------------------
G
M
V
K
G
S
--------------
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
----
A
------
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
--
Q
V
F
V
F
-----------
C
V
G
L
I
---
V
V
A
--
E
I
V
L
W
N
A
--
Q
T
Q
-
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
---------------
L
I
S
K
E
S
P
A
--
G
Y
K
G
----------------
T
A
M
G
V
Y
-
S
T
S
Q
F
L
G
V
A
-
I
----
G
G
S
L
G
G
W
I
D
G
M
F
D
-
G
Q
G
V
F
L
A
G
A
M
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
-------
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
------
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
---------
Y
V
K
I
D
S
K
V
T
N
R
F
E
V
E
Q
A
I
R
Q
A
L
---------
16
Fugue
67.77
12%
-129
- C3 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
------------------------------------------------------------------------------------------------------FKPAP
H
K
A
R
L
P
A
A
E
-
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
-
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
---
K
N
F
A
L
A
M
P
Y
L
-
V
-
E
-
Q
G
F
S
-----
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
---
M
G
S
V
S
D
R
-----
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
----
W
A
-
T
S
SIA
V
---
M
----------------
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
------
W
---
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
-----
C
A
--
H
N
V
G
G
G
I
--
P
P
L
L
F
L
L
G
M
A
--------------------------
W
F
N
D
W
H
A
A
L
Y
M
P
A
F
--------------------
C
A
I
L
V
A
L
F
-------
A
F
A
-
M
M
R
D
T
P
----------------------
Q
S
C
G
L
P
--
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
--------------
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
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V
F
V
Y
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L
R
Y
G
I
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S
P
T
Y
L
K
E
V
----
K
------
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
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T
L
L
C
G
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S
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K
V
F
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G
N
R
G
A
T
G
V
F
F
------
M
T
L
V
T
I
---
A
T
I
--
V
Y
W
-
M
N
P
--
A
G
N
-
P
T
V
D
M
I
C
M
I
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I
G
F
L
I
Y
G
P
V
M
L
I
G
L
---------------
H
A
L
E
L
A
P
K
--
K
A
A
G
----------------
T
A
A
G
F
T
G
L
F
G
Y
L
G
G
S
V
-
A
----
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
-------
K
R
R
H
E
Q
L
L
Q
E
L
V
P
---------------------------------------------------------------------------
17
Fugue
66.58
9%
-101
- C3 -
1PV6
-
LACY_ECOLI
A:
[1-417]
---------------------------------------------------------------------------------------------------------------------
M
Y
Y
L
K
N
T
N
F
W
M
F
G
L
-
F
F
F
F
Y
F
F
I
M
G
A
Y
F
---
P
F
F
P
I
W
L
H
D
I
N
-----
H
I
S
-----
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
---
F
G
L
L
S
D
K
-----
L
G
L
R
K
Y
L
L
W
I
---
I
T
G
M
L
V
M
F
A
P
F
F
I
F
---
I
----
F
G
-
P
L
---
L
Q
YN
I
----------------
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
----
F
N
A
G
A
P
A
V
E
A
F
------
I
---
E
-
K
V
S
R
R
S
N
F
E
-
F
G
-----
R
A
--
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
--------------------------
T
I
N
N
Q
F
V
F
W
L
G
S
G
C
--------------------
A
L
I
L
A
V
L
L
-------
F
F
A
-
K
T
D
A
P
S
S
A
T
V
A
N
A
V
--------------------------
G
A
N
H
S
A
F
S
L
K
L
--------------
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
----
F
------
F
A
T
G
E
Q
G
T
---
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
-------
L
A
G
T
I
M
---
S
V
R
--
I
I
G
-
S
S
F
--
A
T
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
---------------
Y
I
T
S
Q
F
E
V
--
R
F
S
A
----------------
T
I
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
-
I
----
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
-------------------
G
P
G
P
L
------
S
L
L
R
R
Q
V
N
E
V
A
-------------------------------------------------------
30
HHSearch
65.90
12%
-115
- C3 -
2CFQ
-
LACY_ECOLI
A:
[20-395]
---------------------------------------------------------------------------------------------------------------------------------------------
F
F
I
M
---
G
A
Y
F
P
F
F
P
I
W
L
H
-
D
I
N
H
I
S
-----
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
---
F
G
L
L
S
D
K
-----
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
L
Q
Y
N
---
I
---
L
----------------
V
G
-
S
I
V
G
G
I
Y
L
G
F
C
FNAG
A
P
A
V
E
A
F
I
E
K
V
------
S
-----
R
R
S
N
F
E
F
G
R
-
A
R
-----
M
F
--
G
C
V
G
W
A
L
--
G
A
S
I
V
G
I
M
F
T
---------------------------
I
N
N
Q
F
V
F
W
L
G
S
G
C
--------------------
A
L
I
L
A
V
L
L
-------
F
F
A
-
K
T
D
A
P
S
S
A
T
V
A
-
N
A
V
G
A
-------------------------
N
H
S
A
F
S
L
K
L
--------------
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
FAT
G
------
E
Q
G
T
R
V
F
G
---
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
-----------
A
G
T
I
M
---
S
V
R
--
I
I
G
-
S
S
F
--
A
T
S
-
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
---------------
Y
I
T
S
Q
F
E
V
--
R
F
S
A
----------------
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
----
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
S
V
F
T
L
S
G
-------
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
-------------------------------------------------------------------------
26
HHSearch
65.90
12%
-123
- C3 -
1PW4
-
GLPT_ECOLI
A:
[20-431]
----------------------------------------------------------------------------------------------------------------------
D
P
T
Y
R
R
L
R
W
Q
I
F
L
-
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
---
K
N
F
A
L
A
M
P
Y
L
V
--
E
-
Q
G
F
S
-----
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
---
M
G
S
V
S
D
R
-----
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
V
---
P
W
A
T
S
S
I
-
A
V
---
M
---
F
----------------
V
L
-
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
------
W
---
S
Q
K
E
R
G
G
I
V
S
V
-
W
N
-----
C
A
--
H
N
V
G
G
G
I
--
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
N
D
W
H
A
A
L
Y
M
P
A
F
C
--------------------
A
I
L
V
A
L
F
A
-------
F
A
M
-
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
--------------------------
T
A
K
Q
I
F
--------------
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V---
K
------
H
F
A
L
D
K
S
S
---
W
A
Y
F
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
T
G
V
F
--------
F
M
T
L
V
---
T
I
A
--
T
I
V
-
Y
W
M
NP
A
G
N
-
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
---------------
H
A
L
E
L
A
P
K
--
K
A
A
G
----------------
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
----
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
D
G
G
F
M
V
M
I
G
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
-------
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
--------------------------------------------------------------------------
29
HHSearch
65.43
16%
-106
- C3 -
2GFP
-
EMRD_ECOLI
A:
[19-360]
-------------------------------------------------------------------------------------------------------------------------------------------
V
G
Q
M
A
Q
---
T
I
Y
I
P
A
I
A
D
M
A
R
-
D
-
L
N
V
R
-----
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
---
Y
G
P
I
S
D
R
-----
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
T
---
S
----
S
L
-
T
V
---
L
---
I
----------------
A
A
-
S
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
------
Y
---
E
R
T
Q
L
R
H
A
N
S
L
-
L
N
-----
M
G
--
I
L
V
S
P
L
L
--
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
N
W
R
A
C
Y
L
F
L
L
V
L
--------------------
C
A
G
V
T
F
S
M
-------
A
R
W
-
M
P
E
T
R
P
V
D
A
P
R
----------------------------------
T
R
L
L
T
S
--------------
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
---
L
------
G
L
S
S
M
T
V
S
---
I
L
F
I
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
----------
C
C
L
L
A
---
G
L
L
--
M
W
I
-
P
D
W
F
G
V
M
N
-
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
---------------
G
A
M
E
P
F
P
---
F
L
A
G
----------------
T
A
G
A
L
V
-
G
G
L
Q
N
I
G
S
G
-
V
----
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
----------------------------------------------------------------------------------------------------
19
Fugue
63.38
21%
-58
- C1 -
4XB6
-
?
C:
[1-353]
-----------------------------------------------------------------------------------------------------------------------------------------
M
Y
V
A
V
K
G
G
---
E
K
A
I
D
A
A
H
A
L
Q
E
-
S
-
R
R
R
G
-----
D
T
D
L
P
E
L
S
V
A
Q
I
E
Q
Q
L
N
L
A
V
D
---
R
V
M
T
E
G
G
-----
I
A
D
R
E
L
A
A
L
A
---
L
K
Q
A
S
G
D
N
V
E
A
I
F
L
---
L
----
R
A
-
Y
R
---
T
---
T
----------------
L
A
K
---------
L
A
----
V
S
E
P
L
D
T
T
G
M
R
------
L
---
E
-
R
R
I
------------------
S
A
V
Y
K
D
-----
I
P
G
G
Q
L
L
G
---------------------------------------------------------------------------------
P
T
Y
D
Y
T
H
R
L
L
D
F
T
L
L
A
N
G
E
A
P
----------
T
--
L
T
T
A
D
S
E
Q
Q
P
S
P
H
V
F
--------------
S
L
L
A
R
Q
G
L
A
K
F
-----------------------
E
E
D
----
S
------
G
A
Q
P
D
D
I
T
---
R
T
P
P
V
--------
Y
P
C
S
R
S
S
R
L
Q
Q
L
M
R
G
D
E
G
Y
L
L
A
-------
L
A
Y
S
T
Q
R
GY
G
R
N
--
H
P
F
-
A
G
E
--
I
R
S
-------------------
G
Y
I
D
V
S
---------------
I
V
P
E
E
L
G
-----
F
A
----------------
V
N
V
G
E
L
-
L
M
T
E
C
E
M
V
N
-
G
----
F
I
D
P
P
G
E
P
P
H
F
T
R
G
Y
G
L
V
F
G
M
S
E
--------
R
K
A
M
A
M
A
L
-------
V
D
R
A
L
Q
A
P
E
Y
G
E
H
A
T
G
------
P
A
Q
D
E
E
F
V
L
A
H
A
D
------
N
V
E
V
A
G
F
---------
V
S
H
L
K
L
--
P
H
Y
V
D
F
Q
A
E
L
E
L
L
K
R
L
Q
Q
E
Q
N
H-
27
HHSearch
62.94
11%
-121
- C3 -
3O7Q
1
FUCP_ECOLI
A:
[22-422]
----------------------------------------------------------------------------------------------------------------------------
R
S
Y
I
I
P
F
A
L
L
C
S
L
F
F
L
W
A
V
A
N
---
N
L
N
D
I
L
L
P
Q
F
Q
Q
-
A
-
F
T
L
T
-----
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
---
A
G
I
L
M
K
K
-----
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
P
A
A
E
I
M
----
N
Y
-
T
L
---
F
---
L
----------------
V
G
-
L
F
I
I
A
A
G
L
G
C
L
----
E
T
A
A
N
P
F
V
T
V
L
------
G
---
P
E
S
S
G
H
F
R
L
N
L
-
A
Q
-----
T
F
--
N
S
F
G
A
I
I
--
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
--------------------
V
L
L
V
A
L
L
I
-------
M
L
T
K
F
P
A
L
Q
---
S
D
N
H
S
D
A
K
----------------------------
Q
G
S
F
S
A
S
--------------
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I--
P
------
G
M
T
A
G
F
A
A
---
N
Y
L
T
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
K
V
L
A
A
-----------
Y
A
L
I
A
---
M
A
L
--
C
L
I
-
S
A
F
--
A
G
G
-
H
V
G
-
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
---------------
L
G
I
K
N
L
G
Q
--
D
T
K
-----------------
Y
G
S
S
F
I
--
V
M
T
I
I
G
G
G
-
I
----
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
L
I
P
A
L
C
F
A
V
I
F
I
F
A
R
F
R
S
Q
T
-----------------------------------------------------------------------------------------------
22
Fugue
56.80
12%
-92
* C2 *
3P5P
5
TASY_TAXBR
A:
[5-756]
T
Y
Q
E
R
A
D
E
L
V
V
K
I
K
D
M
F
N
A
LGD
G
D
I
S
PS
A
Y
D
T
A
W
V
A
R
L
A
T
I
S
SDGSEKPRF
P
Q
A
L
N
W
V
F
N
N
QLQDGSWGIESHFS
L
C
D
R
L
L
N
T
T
N
S
V
I
A
L
S
V
W
KTG
H
S
Q
V
Q
Q
G
A
E
F
I
A
E
N
L
R
L
L
N
E
-
E
D
E
L
S
P
D
F
Q
I
I
F
P
A
-
L
L
Q
K
A
K
A
L
G
I
N
L
P
YDL
P
F
I
K
Y
L
S
T
T
R
E
A
-
R
-
L
T
D
V
-----
S
A
A
A
D
N
I
P
A
N
M
L
N
A
L
E
G
L
E
E
V
IDW
N
K
I
M
R
F
Q
SKDGS
F
L
S
S
P
A
S
T
A
C
---
V
L
M
N
T
G
D
E
K
C
F
T
F
L
---
N
----
N
L
-
L
D
---
K
---
F
GGCVPCMYSI
D
L
L
E
R
L
S
L
V
D
N
I
E
H
L
G
I
G
R
H
----
F
K
Q
E
I
K
G
A
L
D
Y
------
V
---
Y
-
R
H
W
S
E
R
G
I
G
-
W
G
-----
R
D
--
S
L
V
P
D
L
N
--
T
T
A
L
G
L
R
T
L
R
--------------------------
M
H
G
Y
N
V
S
S
D
V
L
N
N
F
KDENGRFFSSAGQTHVE
L
R
S
V
V
N
L
F
R
A
S
D
L
AFPDE
R
A
M
-
D
D
A
R
K
F
A
E
P
Y
L
R
E
A
L
A
T
K
I
S
T
N
T
K
L
F
K
E
I
E
Y
V
V
E
Y
P
W
H
M
S
I
P
R
L
E
A
R
S
Y
I
D
S
YDDN
Y
V
W
Q
R
K
T
L
Y
R
M
P
S
L
S
N
S
K
C
L
E
L
A
K
L
D
F
N
I
V
Q
S
L
H
Q
E
E
L
K
L
L
T
R
W
W
K
----
E
S
GMADI
N
F
T
R
H
R
V
A
---
E
V
Y
F
S
S
A
T
F
E
P
E
Y
S
A
T
R
I
A
F
T
K
I
G
C
L
Q
V
L
F
D
D
M
A
D
IFAT
L
D
E
L
K
S
F
T
E
---
G
V
K
R
W
D
T
S
-
L
L
H
--
E
I
P
-
E
C
M
Q
T
C
F
K
V
W
F
K
L
M
E
E
V
N
N
D
V
V
K
V
Q
GRDM
L
A
H
I
R
K
P
W
E
L
Y
F
N
C
Y
V
Q
E
--
R
E
W
L
E
A
G
Y
I
P
T
F
E
E
Y
L
K
T
YA
I
S
V
G
L
G
-
P
C
T
L
Q
P
I
L
L
-
M
----
G
E
L
V
K
D
D
V
V
E
K
V
H
Y
P
S
N
M
F
E
L
V
S
L
S
W
R
L
T
N
D
T
K
T
Y
Q
A
E
K
A
R
GQQAS
G
I
A
C
Y
M
K
D
N
P
G
A
T
E
E
D
------
A
I
K
H
I
C
R
V
V
D
R
A
L
K
E
A
S
F
E
Y
F
K
P
S
N
D
IP
M
G
C
K
S
F
I
F
N
L
R
L
C
V
Q
I
F
Y
K
F
N
E
E
I
K
D
Y
I
R
K
V
Y
I
D
P
I
QV
31
HHSearch
53.06
14%
-117
- C3 -
3WDO
-
?
A:
[11-178]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L---
Q
------
G
A
S
E
A
L
I
G
---
I
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
-----------
G
L
A
V
F
---
A
A
G
--
S
V
I
-
A
A
L
--
S
D
S
-
I
W
G
I
I
L
G
R
A
L
Q
G
S
G
A
--
I
A
A
A
V
M
A
---------------
L
L
S
D
L
T
R
E
--
Q
N
R
T
----------------
K
A
M
A
F
I
-
G
V
S
F
G
I
T
F
A
-
I
----
A
M
V
L
G
P
I
I
T
H
K
L
G
-
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
V
V
P
N
-------
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
------
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
---------
T
F
V
A
L
P
G
Q
L
A
D
A
G
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
--
15
PsiBlast_PDB
52.73
24%
-110
- C3 -
4ZYR
1
?
A:
[279-408]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
I
I
N
R
-----
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
--------------------
I
L
K
T
L
H
M
-------
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
-
V
R
F
S
A
T
I
Y
L
-
V
C
FC
F
F
K
Q
L
--
A
M
I
F
M
S
V
--
L
A
---
G
N
M
Y
E
--------------------------
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
--------------------
A
L
G
F
T
L
I
S
-------
V
F
T
-
L
S
G
P
G
P
L
S
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
51.92
24%
-118
- C3 -
1PV7
1
LACY_ECOLI
A:
[279-411]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
I
I
N
R
-----
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
--------------------
I
L
K
T
L
H
M
-------
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
-
V
R
F
S
A
T
I
Y
L
-
V
C
FCFF
K
Q
L
--
A
M
I
F
M
S
V
--
L
A
---
G
N
M
Y
E
--------------------------
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
--------------------
A
L
G
F
T
L
I
S
-------
V
F
T
-
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
51.62
24%
-120
- C3 -
2CFP
-
LACY_ECOLI
A:
[279-411]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
I
I
N
R
-----
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
--------------------
I
L
K
T
L
H
M
-------
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
-
V
R
F
S
A
T
I
Y
L
-
V
C
FCFF
K
Q
L
--
A
M
I
F
M
S
V
--
L
A
---
G
N
M
Y
E
--------------------------
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
--------------------
A
L
G
F
T
L
I
S
-------
V
F
T
-
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
51.35
20%
-109
* C3 *
2CFQ
-
LACY_ECOLI
A:
[257-396]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-----
T
R
V
F
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
---
A
P
L
I
I
N
R
-----
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
----------------
I
L
K
-
T
L
H
M
F
E
V
P
F
L
----
L
V
G
C
F
K
Y
I
T
S
Q
------
F
---
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
-----
F
F
--
K
Q
L
A
M
I
F
--
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
--------------------
A
L
G
F
T
L
I
S
-------
V
F
T
-
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
50.89
24%
-117
- C3 -
1PV6
-
LACY_ECOLI
A:
[279-411]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
I
I
N
R
-----
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
--------------------
I
L
K
T
L
H
M
-------
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
-
V
R
F
S
A
T
I
Y
L
-
V
C
FCFF
K
Q
L
--
A
M
I
F
M
S
V
--
L
A
---
G
N
M
Y
E
--------------------------
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
--------------------
A
L
G
F
T
L
I
S
-------
V
F
T
-
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
50.83
24%
-116
- C3 -
2CFQ
-
LACY_ECOLI
A:
[279-411]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
I
I
N
R
-----
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
--------------------
I
L
K
T
L
H
M
-------
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
-
V
R
F
S
A
T
I
Y
L
-
V
C
FC
F
F
K
Q
L
--
A
M
I
F
M
S
V
--
L
A
---
G
N
M
Y
E
--------------------------
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
--------------------
A
L
G
F
T
L
I
S
-------
V
F
T
-
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
50.71
25%
-118
- C3 -
2Y5Y
-
LACY_ECOLI
A:
[281-403]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
I
N
R
-----
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
--------------------
I
L
K
T
L
H
M
-------
F
E
V
P
F
L
L
V
G
S
F
K
Y
I
T
S
Q
F
---
E
-
V
R
F
S
A
T
I
Y
L
-
V
A
-----
F
A
F
F
K
Q
L
A
M
I
F
--
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
--------------------
A
L
G
F
T
L
I
S
-------
V
F
T
-
L
S
G
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
50.10
24%
-121
- C3 -
2V8N
-
LACY_ECOLI
A:
[279-411]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
I
I
N
R
-----
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
A
---
T
----
S
A
-
L
E
---
V
---
V
--------------------
I
L
K
T
L
H
M
-------
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
-
V
R
F
S
A
T
I
Y
L
-
V
C
FCFF
K
Q
L
--
A
M
I
F
M
S
V
--
L
A
---
G
N
M
Y
E
--------------------------
S
I
G
F
Q
G
A
Y
L
V
L
G
L
V
--------------------
A
L
G
F
T
L
I
S
-------
V
F
T
-
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------