@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NPT4_HUMAN: (2015-12-08 )
MATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPAKSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30----....-....40.....--.-----------..50.......-.60........70........80.---.---------...--...90........100.......110.......120.........130.-..-....140...-----------------...--------------------------.150....-----.....160....-------------------...170.----------------------....--------..180.......190.......200.-.-.....-----210.----....-----..220.------......230.-------------------------------------.---.....240----------......-.---..250.....-------..260...----------------.....270------.........280......-------..290......------------.300..-...-------..310--.----.-..-.--.--.--.320......-----------.330.-......-.340..-.-.-...350...-..-..-360..-.....370----..------...---.----..380------------........390.-------------......400.......410......--.420---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------MATKTELSPTARESKNAQDMQVDETLIPRK
V
----
P
S
L
C
-
S
AR
Y
G
I
A
L
V
L
H
--F-----------C
N
F
T
T
I
A
Q
N
V
I
-
M
N
I
T
M
V
A
M
VNSTSPQSQLNDSS
E
V
---
L
---------PVD--SFGGLSKAPKSLPAKSSILGG
Q
F
A
I
WEKWG
P
P
Q
E
--
R
S
R
L
C
S
I
A
L
S
G
M
L
-
L
G
-
C
F
T
A
I
L
I
G
G
F
-----------------
I
S
E--------------------------TL--GW
P
F
-----
V
F
Y
I
FG
G
V
G
C
V
C
-------------------
C
L
L
W
F
V
V
----------------------IYDD--------PVSYPWISTS
E
K
E
Y
I
I
S
S
L
K
Q
Q
VGSS-K-QPL
P
I
-----
K
A
M
L
----
R
SL
P
-----
I
W
S
I
C
L
------
G
C
F
S
H
Q
W
L
V
S
-------------------------------------
T
---
M
V
V
Y
I
P
------------
T
Y
I
S
S
V
-
Y
---
H
V
N
IRDN
G
L
L
-------
S
A
L
-
P
F
I
V
----------------
A
W
V
I
G
M
--------
V
G
G
Y
L
A
D
F
L
L
-
T
K
K
F
R
L
I
-------
T
V
R
K
I
A
T
I
L
GS------------LPS
S
A
L
-
I
V
S-------LPYL---N----S-G
Y
-
I
--
T
--
A
--
T
A
L
L
T
L
S
C
G
L
-----------
S
T
L
-
C
-QS
G
I
Y
I
-
N
V
L
DIA-
P
-
R
-
Y
S
S
F
L
M
G
AS-RG-FS-SIA
P
V
-
I
V
PTVS
G
-----
F
L
------LSQ---D----PEF
G
-------------
W
R
N
V
F
F
L
L
F
A
V
N
-------------
L
L
G
L
L
F
Y
L
IFG
E
A
D
V
Q
E
W
A
K
ERKLT--RL-----------
16
Fugue
75.39
11%
-91
- C7 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
------------------------------------------------------------------------------------------------------------------------------------FKPAPHKARLPAAEI
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
E
Q
G
F
S
R
G
D
----
L
G
F
A
-
L
S
G
I
S
I
A
Y
G
F
S
--
K
-----------
F
I
M
G
S
V
S
D
R
S
N
-
P
R
V
F
L
P
A
G
L
I
L
A
A
A
V
M
L
F
M
G
F
V
P
W
---
A
---------
T
S
S
--
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
--
R
G
G
I
V
S
V
W
N
C
A
H
N
-
V
G
G
G
I
P
P
L
L
F
L
L
G
-----------------
M
A
W
--------------------------
F
N
--
D
W
H
A
-----
A
L
Y
M
P
A
F
C
A
I
L
V
-------------------
A
L
F
A
F
A
M
----------------------
M
R
D
T
--------
P
Q
S
C
G
L
P
P
I
E
E
Y
K
----------
N
D
T
-
A
-
K
Q
I
F
M
-----
Q
Y
V
L
----
P
N
K
L
-----
L
W
Y
I
A
I
------
A
N
V
F
V
Y
L
L
R
Y
-------------------------------------
G
---
I
L
D
W
S
P
------------
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
-------
Y
F
L
-
Y
E
Y
A
----------------
G
I
P
G
T
L
--------
L
C
G
W
M
S
D
K
V
F
-
R
G
N
R
G
A
T
-------
G
V
F
F
M
T
L
V
T
I
A
------------
T
I
V
Y
W
-------------
M
N
P
---
A
----
G
-
N
P
-
T
--
V
--
D
--
M
I
C
M
I
V
I
G
F
L
-----------
I
Y
G
-
P
-
V
M
L
I
G
L
-
H
A
L
E
L
A
-
P
-
K
-
K
A
A
G
T
A
A
G
F
-
T
G
-
L
F
-
G
Y
L
G
G
-
S
V
A
A
S
A
I
-----
V
G
------
Y
T
V
---
D
----
F
-
F
G
-------------
W
D
G
G
F
M
V
M
I
G
G
S
-------------
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
--
V
P
-----------
6
HHSearch
72.19
13%
-142
- C7 -
1PW4
-
GLPT_ECOLI
A:
[141-434]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
R
T
M
V
H
W
W
S
Q
K
E
--
R
G
G
I
V
S
V
W
N
C
A
H
N
-
V
G
-
G
G
I
P
P
L
L
F
L
L
-----------------
G
M
A
W-------------------------
F
N
--
D
W
H
A
-----
A
L
Y
M
P
A
F
C
A
I
L
V
-------------------
A
L
F
A
F
A
M
----------------------
M
R
D
T
--------
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
-----------T
A
-
K
Q
I
F
M
-----
Q
Y
V
L
----
P
N
K
L
-----
L
W
Y
I
A
I
------
A
N
V
F
V
Y
L
L
R
Y
-------------------------------------
G
---
I
L
D
W
S
P
------------
T
Y
L
K
E
V
-
K
---
H
F
A
L
D
K
S
S
W
A
-------
Y
F
L
-
Y
E
Y
A
----------------
G
I
P
G
T
L
--------
L
C
G
W
M
S
D
K
V
F
-
R
G
N
R
G
A
T
------------
G
V
F
F
-
M
------------
T
L
V
T
I
A
-
T
I
V
-------
Y
W
M
N
PA-
G
----
N
-
P
T
-
V
--
D
--
M
--
I
C
M
I
V
I
G
F
L
I
-----------
Y
G
P
---
V
M
L
I
G
L
-
H
A
L
E
L
A
-
P
K
K
-
A
A
G
T
A
A
G
F
T
-
G
L
-
F
G
-
Y
L
G
G
S
V
A
A
S
A
I
V
G
-----
Y
T
------
V
D
F
----------
F
G
-------------
W
D
G
G
F
M
V
M
I
G
G
S
-------------
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
--
V
P
-----------
22
Fugue
69.49
14%
-99
- C2 -
3CTZ
1
XPP1_HUMAN
A:
[3-619]
PKVT
S
E
L
L
R
Q
L
R
Q
A
M
R
NSEYVTEPIQ
A
Y
I
I
P
SGDAHQSEYIAPCDC
R
R
A
F
V
S
GFDGS
A
G
T
A
I
I
T
EE
H
A
A
M
W
T
D
GRY
F
L
Q
A
A
K
Q
M
DSN
W
T
L
M
K
M
GLKDTPT
Q
E
D
W
L
V
S
V
LPEG
S
R
V
G
V
DPLIIP
T
D
Y
W
K
K
M
A
K
V
L
R
S
A
G
H
H
L
I
P
V
KEN
L
V
D
K
I
WTDRPER
P
C
K
P
L
L
T
L
G
L
D
Y
T
G
I
S
W
K
D
K
V
A
D
L
R
L
K
M
A
E
R
N
V
----
M
W
F
V
V
T
A
L
D
E
I
A
W
L
F
N
--
L
R
G
SDVEHNPV
F
F
S
Y
A
I
I
G
L
E
T
I
-
M
L
F
I
D
G
D
R
I
D
A
P
S
V
K
E
H
L
L
L
D
L
G
L
---
E
---------
A
E
Y
R
I
Q
V
H
P
Y
K
S
I
L
S
E
L
K
A
L
C
A
D
L
S
P
R
E
K
V
W
V
S
D
K
A
S
Y
A
--
V
S
E
T
I
P
K
D
H
R
C
C
M
-
P
Y
-
T
P
I
C
I
A
K
A
V
K
-----------------
N
S
A
--------------------------
E
S
--
E
G
M
R
-----
R
A
H
I
K
D
A
V
A
L
C
E
-------------------
L
F
N
W
L
E
K
----------------------
E
V
P
K
GGVT
E
I
S
A
A
D
K
A
E
E
F
R
R
Q
Q
A
D
F
V
D
L
S
F
P
T
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S
S
T
G
-
P
-
T
G
A
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Y
A
P
V
P
E
T
N
----
R
T
L
S
-----
L
D
E
V
Y
L
------
I
D
S
G
A
Q
Y
K
D
G
-------------------------------------
T
---------------------
T
D
V
T
R
T
-
M
---
H
F
E
T
P
T
A
Y
E
K
-------
E
C
F
-
T
Y
V
L
----------------
K
G
H
I
A
V
S
A
A
V
F
P
TG
T
K
G
H
L
L
D
S
F
A
-
R
S
A
L
W
D
S
GLDYLHG
T
G
H
G
V
G
S
F
L
-
N
------------
V
H
E
G
P
C
-
G
I
S
-------
Y
K
T
F
---
S
----
D
-
E
P
-
L
--
E
--
A
--
G
M
I
V
T
D
E
P
G
Y
-----------
Y
E
D
-
G
-
A
F
G
I
R
I
E
N
V
V
L
V
V
-
P
-
V
-
K
T
K
Y
N
F
N
N
R
-
G
S
-
L
T
-
L
E
P
L
T
-
L
V
P
I
Q
T
K
-----
M
I
------
D
V
D
SLT
D
----
K
E
C
D
-------------
W
L
N
N
Y
H
L
T
C
R
D
V
-------------
I
G
K
E
L
Q
K
--
Q
G
R
Q
E
A
L
E
W
L
I
R
E
T
Q
P
--
I
------------
21
Fugue
66.77
17%
-127
- C5 -
4D79
3
TCDA_ECOLI
A:
[3-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
S
D
A
W
R
Q
R
F
G
G
T
-
A
-
R
L
Y
G
E
-----
K
A
L
Q
----
L
F
A
D
-----
A
-
H
I
C
V
V
G
IGGV
G
S
W
A
A
E
A
L
A
R
-------------------------------------
T
GIG
A
I
T
L
I
D
------------
M
D
D
V
C
V
-
T
---
N
T
N
R
Q
I
H
A
L
R
-------
D
N
V
G
L
A
K
A
----------------
E
V
M
A
E
R
--------
I
R
Q
I
N
P
E
C
R
V
-
T
V
V
D
D
F
V
-------
T
P
D
N
V
A
Q
Y
M
S
V
GYS
Y
V
I
D
AIDS
V
R
P
K
A
A
L
-
I
A
Y
-------
C
R
R
N
---
K
----
I
-
P
L
-
V
--
T
--
T
----------
G
G
-----------
A
G
G
-
Q
-
I
D
P
T
Q
I
-
Q
V
T
D
L
A
-
K
-
T
-
I
Q
D
P
L
A
A
K
L
-
R
E
-
R
L
-
K
S
D
F
G
-
V
V
K
N
S
K
G
KLG
V
D
C
V
------
F
S
T
---
E
ALVY
P
G
F
G
-------------
A
A
T
M
V
T
A
T
F
G
F
V
-------------
A
V
S
H
A
L
K
K
M
M
A
K
A
A
R
Q
G
-----------------------
9
HHSearch
63.14
13%
-129
- C7 -
3WDO
-
?
A:
[117-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
--
R
T
K
A
M
A
F
I
G
V
S
F
G
-
I
T
-
F
A
I
A
M
V
L
G
P
I
-----------------
I
T
H
--------------------------
K
L
--
G
L
H
A
-----
L
F
W
M
I
A
I
L
A
T
T
G
-------------------
I
A
L
T
I
W
V
----------------------
V
P
N
S
--------
S
T
H
V
L
---
N
R
E
S
G
--------------
M
-
V
K
G
S
F
-----
S
K
V
L
----
A
E
P
R
-----
L
L
K
L
N
F
------
G
I
M
C
L
H
M
L
L
M
-------------------------------------
S
---
T
F
V
A
L
P
------------
G
Q
L
A
D
--
A
---
G
F
P
A
A
E
H
W
K
V
-------
Y
L
A
-
T
-
M
L
----------------
I
A
F
G
S
V
--------
V
P
F
I
I
Y
A
E
V
K
-
R
K
M
K
Q
V
------------
F
V
F
C
V
G
L
------------
I
V
V
A
-
E
-
I
V
L
-------
W
N
A
Q
---
T
----
Q
-
F
W
-
Q
--
L
V
V
G
--
V
Q
L
F
F
V
A
F
N
L
-----------
M
-----
E
A
L
L
P
S
-
L
I
S
K
E
S
-
P
A
G
-
Y
K
G
T
A
M
G
V
Y
-
S
T
-
S
Q
-
F
L
G
V
A
-
I
G
G
S
L
G
G
-----
W
I
------
D
G
M
----------
F
D
-------------
G
Q
G
V
F
L
A
G
A
M
L
A
-------------
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
--
D
I
-----------
10
HHSearch
62.98
15%
-126
- C7 -
2CFQ
-
LACY_ECOLI
A:
[135-393]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
S
N
F
E
F
G
R
A
R
M
F
G
C
-
V
G
-
W
A
L
G
A
S
I
V
G
I
-----------------
M
F
T
---------------------------
I
--
N
N
Q
F
-----
V
F
W
L
G
S
G
C
A
L
I
L
-------------------
A
V
L
L
F
F
A
----------------------
K
T
D
A
--------
P
S
S
A
T
V
A
-
N
A
V
G
--------
A
N
-
H
S
A
-
F
-
S
L
K
L
A
-----
L
E
L
F
----
R
Q
P
K
-----
L
W
F
L
S
L
------
Y
V
I
G
V
S
C
T
Y
D
-------------------------------------
V
---
F
D
Q
Q
F
A
------------
N
F
F
T
S
F
-
F
AT
G
E
Q
G
T
R
V
F
G
Y
V
-------
T
T
M
-
G
E
L
L
----------------
N
A
S
I
M
F
--------
F
A
P
L
I
I
N
R
I
G
-
G
K
N
A
L
L
L
----------------
A
G
------------
T
I
M
S
V
R
-
I
I
G
-------
S
S
F
A
---
T
----
S
-
A
L
-
E
--------
V
V
I
L
K
T
L
H
M
F
-----------
E
V
P
-
F
L
L
V
G
C
F
K
-
Y
I
T
S
Q
F
E
V
-
R
-
F
S
A
T
I
Y
L
V
C
F
C
F
-
F
K
-
Q
L
A
M
I
-
F
M
S
V
L
A
G
-----
N
M
------
Y
E
S
----------
I
G
-------------
F
Q
G
A
Y
L
V
L
G
L
V
A
-------------
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
--
E
V
-----------
19
Fugue
62.37
20%
-100
- C4 -
4UT1
20
?
A:
[79-633]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
Q
L
N
A
A
Q
T
Q
G
S
S
L
S
T
Y
Y
T
L
V
A
Q
L
N
----
N
Y
V
G
-
S
P
T
A
G
I
A
T
A
I
T
N
Y
F
-----------
T
G
L
Q
T
V
A
N
N
A
A
D
P
S
A
R
Q
T
A
M
S
N
A
Q
T
L
A
S
Q
L
V
A
A
G
Q
Q
Y
S
Q
L
---------
R
Q
S
--
V
N
S
Q
L
T
D
T
V
T
Q
I
N
S
Y
T
S
Q
I
A
Q
L
N
E
Q
I
A
S
A
S
S
P
N
Q
--
L
L
D
Q
R
D
L
A
V
S
K
L
S
Q
L
A
-
G
V
Q
V
V
Q
S
N
G
N
-----------------
Y
S
V
--------------------------
F
L
SG
G
Q
P
L
-----
V
V
------
G
N
A
S
-------------------
Y
Q
L
A
T
V
A
----------------------
S
P
S
D
--------
P
S
E
L
T
I
V
S
K
G
V
A
G
S
A
Q
P
G
P
T
Q
Y
L
P
D
V
-
S
L
T
G
G
A
L
-----
G
G
L
L
A
F
R
S
Q
T
L
D
-----
P
A
Q
A
Q
L
------
G
A
L
A
V
S
F
A
S
Q
V
N
A
Q
N
A
L
G
VDMSGNPGGSL
F
A
V
G
A
P
AVYANQNNTGS
A
T
---
L
S
V
S
F
V
DGTQPTT
S
D
Y
A
L
S
Y
D
G
A
K
-
Y
---
T
L
T
D
R
A
T
G
S
V
V
G
T
A
T
P
S
S
T
P
-
P
T
M
T
I
GG
L
K
L
S
L
SSTPNAG
D
S
F
T
V
L
P
--------
T
R
G
A
L
D
G
F
S
L
A
T
A
N
G
S
A
I
-------
A
A
A
S
P
V
L
A
A
G
V
------------
A
T
N
S
G
T
G
V
I
S
-------
Q
G
S
V
---
S
----
A
-
G
Y
-
Q
--
L
--
P
--
S
G
T
T
T
L
A
Y
N
A
ASKTLSGFPVG
T
T
V
-
T
-
I
A
G
T
P
P
-
T
S
I
N
I
T
-
S
-
A
-
T
T
P
V
P
Y
D
P
S
-
K
G
-
A
S
M
T
I
S
S
T
-
T
Q
P
A
P
S
G
-----
V
M
NG
V
S
V
S
L
S
G
---
T
----
P
A
D
G
D
Q
F
T
I
G
ANKGTND
G
R
N
A
L
A
L
S
Q
L
V
N
SKTMNNGTTT
L
T
G
A
Y
A
G
Y
V
N
A
I
G
N
A
A
S
Q
L
K
A
S
S
A
A
Q
T
A
--
L
V
G
Q
I
T
Q
A
Q
Q
S
VS
20
Fugue
57.46
11%
-67
* C7 *
1PV6
-
LACY_ECOLI
A:
[1-417]
----------------------------------------------------------------------------------------------------------------------------------MYYLKNT
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
P
I
W
L
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
----
F
G
L
L
-
S
D
K
L
G
---------------------------
L
R
K
Y
-
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
P
L
L
---
Q
---------
Y
N
I
--
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
R
S
N
--
F
E
--
F
G
R
A
R
M
F
G
C
-
V
G
-
W
A
L
G
A
S
I
V
G
I
-----------------
M
F
T
--------------------------
I
---
N
N
Q
F
-----
V
F
W
L
G
S
G
C
A
L
I
L
-------------------
A
V
L
L
F
----------------------------------------
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
A
N
H
S
A
-
F
-
S
L
K
L
A
-----
L
E
L
F
----
R
Q
P
K
-----
L
W
F
L
S
L
------
Y
V
I
G
V
S
C
T
Y
D
-------------------------------------
V
---
F
D
Q
Q
F
A
------------
N
F
F
T
S
F
-
F
---
A
T
G
E
Q
G
T
R
V
F
-------
G
Y
V
-
T
T
M
G
----------------
E
L
L
N
A
S
--------
I
M
F
F
A
P
L
I
I
N
-
R
I
G
-------------
G
K
N
A
L
L
L
A
G
------------
T
I
M
S
V
R
-
I
I
G
-------
S
S
F
A
---
T
----
S
-
A
L
-
E
--
V
--
V
--
I
L
K
T
L
H
M
F
E
V
-----------
P
F
L
-
L
-
V
G
C
F
K
Y
-
I
T
S
Q
F
E
-
V
-
R
-
F
S
A
T
I
Y
L
V
C
-
F
C
F
F
K
-
Q
L
A
M
I
-
F
M
S
V
L
A
G
-----
N
M
------
Y
E
S
---
I
-------
G
-------------
F
Q
G
A
Y
L
V
L
G
L
V
A
-------------
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
--
E
V
A----------
12
HHSearch
56.71
18%
-133
- C7 -
2CFQ
-
LACY_ECOLI
A:
[4-183]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
K
N
T
N
-----
F
W
M
F
G
L
------
F
F
F
F
Y
F
F
I
M
G
-------------------------------------
A
---
Y
F
P
F
F
P
------------
I
W
L
H
D
I
-
N
---
H
I
S
K
S
D
T
G
I
I
-------
F
A
A
-
I
S
L
F
----------------
S
L
L
F
Q
P
--------
L
F
G
L
L
S
D
K
L
G
-
L
R
K
Y
L
L
W
-------------
I
I
T
G
M
------------
L
V
M
F
A
P
-
F
F
I
-------
F
I
F
G
---
P
----
L
L
Q
Y
N
I
L-
V
--
G
--
S
I
V
G
G
I
Y
L
G
F
-----------
C
F
N
A
G
-
A
P
A
V
E
A
-
F
I
E
K
V
S
-
R
---
R
S
N
F
E
F
G
R
A
-
R
M
-
F
G
-
C
V
G
W
A
-
L
G
A
S
I
V
G
-----
I
M
------
F
T
-----------
I
N
-------------
N
Q
F
V
F
W
L
G
S
G
C
A
-------------
L
I
L
A
V
L
L
F
F
A
K
T
D
A
P
S
S
A
T
V
A
N
A
V
G
--
A
N
-----------
23
Fugue
50.16
13%
-95
- C1 -
1EHK
5
COX1_THET8
A:
[14-562]
---------------------------------------------------------------------------------------------------------------------------------AYP
E
K
K
A
T
L
Y
F
L
V
L
G
F
L
A
L
I
V
G
S
L
F
G
P
F
Q
A
L
N
Y
G
N
V
D
A
Y
P
L
L
K
R
L
L
P
F
V
Q
S
Y
Y
Q
G
L
T
L
H
G
V
L
N
AI
V
F
T
Q
L
F
-
A
Q
A
I
M
V
Y
L
P
A
R
--
E
-----------
L
N
M
R
P
N
M
G
L
M
W
-
L
S
W
W
M
A
F
I
G
L
V
V
A
A
L
P
L
L
A
N
E
A
T
V
---
L
YTFYPPLKG
H
W
A
--
F
Y
L
G
A
S
V
F
V
L
S
T
W
V
S
I
Y
I
V
L
D
L
W
R
R
W
K
A
A
N
P
G
K
V
TP
L
V
T
Y
M
A
V
V
F
W
L
M
W
-
F
L
-
A
S
L
G
L
V
L
E
A
V
L
F
L
L
P
W
S
F
GLVEGVD
P
L
V
A
R
--------------------------
T
L
--
F
W
W
T
G
H
P
I
V
Y
F
W
L
L
P
A
Y
A
I
I
Y
TI
L
P
K
Q
A
GGKLVS
D
P
M
A
R
L
A
F
L
L
F
L
L
LSTPVGFHHQFADPGID
P
T
W
K
M
I
H
S
V
--------
L
T
L
F
V
A
V
P
S
L
M
T
A
F
T
V
A
A
S
L
E
F
A
G
R
L
-
R
-
G
G
R
G
L
-----
F
G
W
I
----
R
A
L
P
WDN
P
A
F
V
A
P
V
L
------
G
L
L
G
F
I
P
G
G
A
-------------------------------------
G
---
G
I
V
N
A
S
F
T
L
D
Y
V
V
HNT--
A
W
V
P
G
H
-
F
---
H
L
Q
V
A
S
L
V
T
L
-------
T
A
M
-
G
S
L
Y
----------------
W
L
L
P
N
L
--------
T
G
K
P
I
S
D
A
Q
R
-
R
L
G
L
A
V
V
-------
W
L
W
F
L
G
M
M
I
M
A
------------
V
G
L
H
W
A
-
G
L
L
NVPRRAY
I
A
Q
V
---
P
----
D
-
A
Y
-
P
--
H
--
A
--
A
V
P
M
V
F
N
V
L
A
-----------
G
I
V
-
L
-
L
V
A
L
L
L
-
F
I
Y
G
L
F
-
S
-
V
-
L
L
S
R
L
A
E
A
P
-
L
P
-
F
A
-
E
V
I
S
G
---
P
E
D
R
R
-----
L
V
------
L
A
M
---
D
----
R
----------------------
I
G
F
W
F
A
-------------
V
A
A
I
L
V
V
L
A
Y
G
P
T
L
V
Q
L
F
G
H
L
N
P
V
P
G
W
R
L
W----------
11
HHSearch
46.06
13%
-125
- C7 -
3WDO
-
?
A:
[12-178]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
G
L
G
T
------
V
F
S
L
R
M
L
G
M
F
-------------------------------------
M
---
V
L
P
V
L
T
------------
T
Y
G
M
A
L
-
Q
---
G
A
S
E
A
L
I
G
I
A
-------
I
G
I
-
Y
G
L
T
----------------
Q
A
V
F
Q
I
--------
P
F
G
L
L
S
D
R
I
G
-
R
K
P
L
I
V
G
----------------
G
L
------------
A
V
F
A
A
G
-
S
V
I
-------
A
A
L
S
---
D
----
S
-
I
W
-
G
--
I
--
I
--
L
G
R
A
L
Q
G
S
G
A
---------------
I
-
A
A
A
V
M
A
-
L
L
S
D
L
T
-
R
E
Q
-
N
R
T
K
A
M
A
F
I
-
G
V
-
S
F
-
G
I
T
F
A
-
I
A
M
V
L
G
P
-----
I
I
------
T
H
K
----------
L
G
-------------
L
H
A
L
F
W
M
I
A
I
L
A
-------------
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
--
V
K
-----------
8
HHSearch
44.25
11%
-94
- C7 -
2GFP
-
EMRD_ECOLI
A:
[117-373]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
T
L
P
R
D
L
Y
E
R
T
Q
--
L
R
H
A
N
S
L
L
N
M
G
I
L
-
V
S
-
P
L
L
A
P
L
I
G
G
L
-----------------
L
D
T
--------------------------
M
W
--
N
W
R
A
-----
C
Y
L
F
L
L
V
L
C
A
G
V
-------------------
T
F
S
M
A
R
W
----------------------
M
P
E
T
--------
R
P
V
D
-----
A
P
R
T
--------------
R
-
L
L
T
S
Y
-----
K
T
L
F
----
G
N
S
G
-----
F
N
C
Y
L
L
------
M
L
I
G
G
L
A
G
I
A
-------------------------------------
A
---
F
E
A
C
S
G
------------
V
L
M
G
A
V
-
L
---
G
L
S
S
M
T
V
S
I
L
-------
F
I
L
-
P
I
P
A
----------------
A
F
F
G
A
W
--------
F
A
G
R
P
N
K
R
F
S
-
T
L
M
W
---------------
Q
S
V
I
C
C
------------
L
L
A
G
L
L
-
M
W
I
-------
P
D
W
F
---
G
V
M
--
N
-
V
W
-
T
--
L
--
L
V
P
A
A
L
F
F
F
G
A
G
M
---------------
L
-
F
P
L
A
T
S
-
G
A
M
E
P
F
-
P
-
F
-
L
A
G
T
A
G
A
L
V
-
G
G
-
L
Q
-
N
I
G
S
G
-
V
L
A
S
L
S
A
-----
M
L
------
P
Q
T
--------
G
Q
G
S
-------------
L
G
L
L
M
T
L
M
G
L
L
I
-------------
V
L
C
W
L
P
L
---------------------------------
5
PsiBlast_CBE
38.09
35%
57
- C8 -
1WWL
1
CD14_MOUSE
B:
[261-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
T
G
L
K
Q
V
P
K
G
L
P
A
K
L
S
V
L
D
L
S
Y
N
R
L
D
R
N
P
S
P
D
E
--
L
P
Q
V
G
N
L
S
L
K
G
N
P
-
F
L
-
D
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
37.99
35%
61
- C8 -
1WWL
1
CD14_MOUSE
A:
[261-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
T
G
L
K
Q
V
P
K
G
L
P
A
K
L
S
V
L
D
L
S
Y
N
R
L
D
R
N
P
S
P
D
E
--
L
P
Q
V
G
N
L
S
L
K
G
N
P
-
F
L
-
D
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
34.51
13%
-105
- C7 -
3O7Q
1
FUCP_ECOLI
A:
[40-177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
N
N
-------------------------------------
L
---
N
D
I
L
L
P
------------
Q
F
Q
-
Q
A
-
F
---
T
L
T
N
F
Q
A
G
L
I
-------
Q
S
A
-
F
Y
F
G
----------------
Y
F
I
I
P
I
--------
P
A
G
I
L
M
K
K
L
S
-
Y
K
A
G
I
I
T
----------------
G
L
------------
F
L
Y
A
L
G
-
A
A
L
-------
F
W
P
A
A
E
I
M
----
N
-
Y
T
-
L
--
F
L
V
G
--
L
F
I
I
A
A
G
L
G
C
-----------
L
-----
E
T
A
A
N
P
-
F
V
T
V
L
G
-
P
-
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
-
F
N
-
S
F
G
A
I
-
I
A
V
V
F
G
Q
-----
S
L
------
I
L
S
---
N
----
V
P
H
Q
-------------
S
Q
D
V
L
D
K
M
S
P
E
Q
-------------
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
--
V
A
-----------
14
HHSearch
32.73
13%
-91
- C7 -
2GFP
-
EMRD_ECOLI
A:
[26-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
Y
I
P
A
I
A
------------
D
M
-
A
R
D
-
L
---
N
V
R
E
G
A
V
Q
S
V
-------
M
G
A
-
Y
L
L
T
----------------
Y
G
V
S
Q
L
--------
F
Y
G
P
I
S
D
R
V
G
-
R
R
P
V
I
L
V
----------------
G
M
------------
S
I
F
M
L
A
-
T
L
V
-------
A
V
T
T
---
S
----
S
-
L
T
-
V
LI
A
--
A
--
S
A
M
Q
G
M
G
T
G
V
---------------
G
-
G
V
M
A
R
T
-
L
P
R
D
L
Y
-
E
R
T
-
Q
L
R
H
A
N
S
L
L
-
N
M
-
G
I
-
L
V
S
P
L
-
L
A
P
L
I
G
G
-----
L
L
------
D
T
M
----------
W
N
-------------
W
R
A
C
Y
L
F
L
L
V
L
C
-------------
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
--
T
S
-----------
15
HHSearch
32.47
11%
-96
- C7 -
1PW4
-
GLPT_ECOLI
A:
[54-201]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
E
--
Q
---
G
F
S
R
G
D
L
G
F
A
-------
L
S
G
-
I
S
I
A
----------------
Y
G
F
S
K
F
--------
I
M
G
S
V
S
D
R
S
N
-
P
R
V
F
L
P
A
----------------
G
L
------------
I
L
A
A
A
V
-
M
L
F
-------
M
G
F
V
---
P
W
A
T
S
S
-
I
A
-
V
--
M
F
V
L
--
L
F
L
C
G
W
F
Q
G
M
-----------
G
-----
W
P
P
C
G
R
-
T
M
V
H
W
W
S
Q
-
K
-
E
R
G
G
I
V
S
V
W
-
N
C
-
A
H
-
N
V
G
G
G
-
I
P
P
L
L
F
L
-----
L
G
------
M
A
W
---------
F
N
D
-------------
W
H
A
A
L
Y
M
P
A
F
C
A
-------------
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
--
Y
K
-----------
3
PsiBlast_PDB
27.72
36%
55
* C8 *
4GLP
-
CD14_HUMAN
A:
[260-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
A
T
V
N
P
S
A
P
R
C
M
W
S
S
A
L
N
S
---
L
---------
N
L
---
S
F
A
G
L
E
Q
V
P
K
G
L
P
A
K
L
R
V
L
D
L
S
S
N
R
L
N
R
A
P
Q
P
D
E
--
L
P
E
V
D
N
L
T
L
D
G
N
P
-
F
L
-
V
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
24.71
12%
-78
- C7 -
3O7Q
1
FUCP_ECOLI
A:
[137-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
N
P
F
V
T
V
L
G
P
E
S
S
--
G
H
F
R
L
N
L
A
Q
T
F
N
S
-
F
G
-
A
I
I
A
V
V
F
G
Q
S
-----------------
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
--
S
V
Q
T
-----
P
Y
M
I
I
V
A
I
V
L
L
V
-------------------
A
L
L
I
M
L
------------------------
T
K
F
--------
P
A
L
Q
S
D
N
-
H
S
D
A
K
-----------
Q
G
-
S
-
F
S
A
S
L
-----
S
R
L
A
----
R
I
R
H
-----
W
R
W
A
V
L
------
A
Q
F
C
Y
V
G
A
Q
T
-------------------------------------
A
---
C
W
S
Y
L
I
------------
R
Y
A
V
E
E
I
P
---
G
M
T
A
G
F
A
A
N
Y
-------
L
T
G
-
T
M
V
C
----------------
F
F
I
G
R
F
--------
T
G
T
W
L
I
S
R
F
A
-
P
H
K
V
L
A
A
-------
Y
A
L
I
A
M
A
L
C
L
I
------------
S
A
F
A
G
G
-
H
V
G
-------
L
I
A
L
---
T
----
L
-
C
S
-
A
--
F
--
M
--
S
I
Q
Y
P
T
I
F
S
L
-----------
G
I
K
-
N
-
L
G
Q
D
T
K
-
Y
G
S
S
F
I
-
V
-
M
-
T
I
I
G
G
G
I
V
T
-
P
V
-
M
G
-
F
V
S
D
A
-
A
G
N
I
P
T
A
-----
E
L
------
I
P
A
---
L
----
C
F
A
V
-------------
I
F
I
F
A
R
F
R
S
Q
T
------------------------------------------------------
4
PsiBlast_PDB
24.61
39%
-128
- C3 -
4W6V
-
?
A:
[156-200]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
F
Y
M
G
I
N
-
M
G
-
S
F
I
A
P
L
L
S
G
W
-----------------
L
L
R
--------------------------
T
H
--
G
W
H
W
-----
G
F
G
I
-
G
G
I
G
M
L
V
-------------------
A
L
L
I
F
R
G
----------------------
F
A
I
P
--------
A
M
K
R
Y
D
A
E
V
G
L
D
S
S
W
N
K
P
T
G
R
W
V
T
A
I
-
M
-
A
V
V
V
V
-----
I
I
A
L
----
I
S
Q
G
-----
V
I
P
I
N
P
------
V
M
I
A
S
L
L
V
Y
V
-------------------------------------
I
---
A
A
S
V
T
L
------------
Y
F
I
Y
L
F
-
A
---
F
A
K
M
S
R
K
D
R
A
-------
R
L
L
-
V
C
F
I
----------------
L
L
V
S
A
A
--------
F
F
W
S
A
F
E
Q
K
P
-
T
S
F
N
L
F
A
-------
N
D
Y
T
D
R
M
V
M
G
F
------------
E
I
P
T
V
W
-
F
Q
S
-------
I
N
A
L
---
F
----
I
-
I
L
-
L
--
A
--
P
--
V
F
S
W
A
P
S
S
I
T
-----------
K
F
V
-
I
-
G
I
L
C
A
A
-
A
G
F
A
V
M
-
M
-
Y
-
A
A
Q
H
V
L
S
S
G
-
G
A
-
G
V
-
S
P
L
W
L
-
V
M
S
I
L
L
L
-----
T
L
------
G
E
L
---
C
----
L
S
P
I
-------------
G
L
A
T
M
T
L
L
A
P
D
R
-------------
M
R
G
Q
V
M
G
L
W
F
C
A
S
S
L
G
N
L
A
A
G
L
I
G
G
--
H
V
-----------