@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S22AP_HUMAN: (2015-12-09 )
MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVENEGVNSLAAPQRSSVL
Atome Classification :
(20 SA)
---.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130...-.....140.......150---.....----..160.......170.......---180.......190--------------------..---.----.-....200.-------......210----.......220.......230--......-...240.......250...-----------------------------.------------------.-----------..260.......270...--.-----.--..------------------280.......290.......300.......310.......320.......330...-....340....-------...350.......360........370-.------..--.---.---.------.380..-.-....390.......400....----------...410...---....420.....-.----..--.--430.......440.......450..---.....460.......470-..---.....480......-----.-.--------490------.--........--500.......510-.-.-.....520.--......530.......540.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---M
A
F
Q
D
L
L
D
QVGG
L
G
R
F
Q
I
L
Q
M
V
F
L
I
M
F
N
V
I
V
Y
H
Q
T
Q
L
E
N
F
A
A
F
I
LDH
R
C
W
V
H
I
LDNDTIPDNDPGTLSQD
A
L
L
R
I
S
IPFDSNL
R
P
E
K
C
R
R
FVHP
Q
W
K
L
I
H
LNGTFPNTSEPDTEPCVD
G
W
VYDQSSFPS
T
I
-
V
T
K
-
W
D
L
V
CESQ
P
L
N
S
V
A
K
F
L
F
---
M
A
G
M
M
----VGGN
L
Y
G
H
L
S
D
RFG
R
K
F
V
L
R
W
S
---
Y
L
Q
L
A
I
VG
T
C
A
A
---------------------
F
A
---
P
----
T
-
I
L
V
Y
C
S
L
R
-------
F
L
AG
A
A
T
F
S
----
I
I
V
N
T
V
L
L
I
V
E
W
I
T
H
Q
F
C
----
A
M
A
L
T
L
-
T
L
C
A
A
S
IGH
I
T
L
G
S
L
A
F
V
I
-----------------------------
R
------------------
D
-----------
Q
C
I
L
Q
L
V
MSA
P
C
F
V
F
F
L
F
--
S
-----
R
--
W
L
------------------AESA
R
W
L
I
I
NNK
P
E
E
G
L
K
E
L
R
K
A
A
HRNGMK
N
A
E
D
I
L
T
M
E
V
L
K
S
T
M
K
Q
E
L
E
A
A
Q
K
K
H
-
S
L
C
E
L
L
R
I
P
N
I
-------
C
K
R
I
C
F
L
S
F
V
R
F
A
S-TIPF
W
G
L
T
L
H
L
Q
-
H
------LG--N---
N
---
V
------
F
L
L
Q
T
L
-
F
-
G
A
V
T
L
L
A
N
C
V
A
P
W
A
L
N
H
M
S
R
R
----------
L
S
Q
M
L
L
M
F
L
---
L
A
T
C
L
--
L
A
I
I
F-V----P
Q
--
E
--
M
Q
T
L
R
V
V
L
A
T
LGVGA
A
S
L
G
I
T
CSTA---QEN
E
L
I
P
S
I
IRGRATGIT-GN---
F
A
N
I
G
G
-
A
L
A
S
L
M
M
-----
I
-
L
--------
S
--------
I
--YSRP
L
P
W
I
--
I
Y
G
V
F
A
I
L
S
G
L
V
V
-
L
-
L
-LPETRNQ
P
L
--
L
D
S
I
Q
D
V
E
N
EGVNSLAAPQRSSVL
19
Fugue
88.14
20%
-124
- C1 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
-------------------------------
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
-------------
T
V
E
S
L
N
T
V
---------------
F
V
A
P
Q
N
L
--------------------------------------------
S
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
L
I
G
C
I
----
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
---------------------
W
P
----------
E
L
G
F
T
S
I
N
PDNTVPV
Y
L
A
G
Y
V
P
E
F
----
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
----
P
M
Y
I
A
E
-
L
----
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
-----------------------------
F
------------------
A
-----------
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
-----
S
--
W
L
------------------
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
-----
T
V
P
E
S
P
R
W
L
M
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
R
L
-
L
M
F
G
V
G
V
I
V
I
G
-------
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
-
V
L
Y
Y
A
P
E
V
F
K
T
L
-
G
------
A
S
--
T
---
D
---
I
------
A
L
L
Q
T
I
I
V
-
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
----------
P
L
Q
I
I
G
A
L
G
---
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
----
T
Q
--
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
-
W
V
---
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
---
A
Q
W
L
A
N
-
Y
F
V
S
W
T
F
-----
P
-
M
--------
M
DKN
S
W
L
V
A
H
--
F
H
N
G
F
S
Y
W
--
I
Y
G
C
M
G
V
L
A
A
L
F
M
-
W
K
F
-
V
P
E
T
K
G
K
T
L
--------------------------
13
Fugue
85.77
17%
-121
- C1 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
-------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
-------------------------------------------------------
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
V
A
-----------------------------
S
A
---
L
I
G
C
I
----
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVY---
L
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
-------
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
----
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
-----------------------------
A
------------------
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
--
L
-----
Y
--
T
V
------------------
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
G
N
T
L
A
T
Q
A
V
Q
E
I
K
-
H
S
L
D
H
G
R
K
T
G
G
R
L
L
M
F
G
V
-
G
V
I
V
I
G
V
M
L
S
I
-------
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
-
P
E
V
F
K
T
L
G
A
S
-----------
T
--
D
---
I
---
A
------
L
L
Q
T
I
I
-
V
-
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
----------
P
L
Q
I
I
G
A
L
G
---
M
A
I
G
M
--
F
S
L
G
T
-
A
F
Y
T
Q
A
P
--
G
--
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
---
L
-
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
---
A
Q
W
L
A
N
-
Y
F
V
S
W
T
F
-----
P
-
M
M
D
K
N
S
W
L
V
A
--------
H
--
F
H
N
G
F
S
Y
W
--
I
Y
G
C
M
G
V
L
A
A
L
F
M
-
W
-
K
F
V
P
E
T
K
G
K
T
---
L
E
E
L
E
A
L
W
E
---------------
1
PsiBlast_PDB
82.79
20%
-122
- C1 -
4LDS
-
?
A:
[38-427]
---------------------------------------------------------------------------------------------------------------------------------------------------
P
L
N
S
T
T
E
G
I
V
---
V
S
S
M
L
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
-------
M
L
I
A
I
V
F
I
I
G
A
---------------------
L
--------------------------
I
L
A
A
S
T
N
L
A
----
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
----
T
V
P
V
Y
L
-
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
----------------------------------------------------
N
-----------
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
A
F
--
A
D
I
E
G
W
R
--
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
YFM
P
E
S
P
R
W
L
L
-
E
N
R
N
E
E
A
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
E
-----------
L
K
E
M
K
E
I
N
A
I
S
E
-
S
T
W
T
V
I
K
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
-
V
I
F
Y
S
S
S
I
F
A
K
A
-
G
------
L
G
--
E
---
A
---
A
------
S
I
L
G
S
V
G
I
-
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
N
I
G
M
I
A
S
L
L
I
M
A
I
---
L
---------
I
W
-
T
----
I
G
--
I
--
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
-
A
L
---
V
L
N
I
G
T
-
L
I
V
S
L
F
F
-----
P
-
I
--------
L
--------
S
--
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
L
A
M
I
F
V
-
I
K
F
-
L
P
E
T
R
G
-----------------------------
4
PsiBlast_PDB
81.56
20%
-114
- C1 -
4GBZ
5
XYLE_ECOLI
A:
[67-479]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
I
----
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
W
PELGFTSINPDNTVPVYLAG
Y
V
---
P
----
E
-
F
V
I
Y
---
R
-------
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
----
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
-----------------------------
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
-----------
E
C
I
-------
P
A
L
L
F
L
M
L
--
L
-----
Y
--
T
V
------------------
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
-----
M
G
N
T
---
L
A
T
Q
A
V
Q
E
-
I
K
H
S
L
D
H
G
R
K
T
G
-
G
R
L
L
M
F
G
V
G
V
I
-------
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
-
T
------
L
G
AS
T
---
D
---
I
------
A
L
L
Q
T
I
-
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
----------
P
L
Q
I
I
G
A
L
G
---
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
----
T
Q
--
A
PG
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
---
L
-
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
F
V
-
S
W
T
F
P
M
M
D
K
N
S
W
L
-
V
--------
A
--------
H
--
F
H
N
G
F
S
Y
W
--
I
Y
G
C
M
G
V
L
A
A
L
F
M
-
W
K
F
-
V
P
E
T
K
G
K
T
L
EE
L
E
A
L
W
E
------------------
6
PsiBlast_PDB
81.11
20%
-127
- C1 -
4JA4
-
XYLE_ECOLI
A:
[67-479]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
I
----
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
W
PELGF
T
S
I
N
P
D
N
T
V
PVYLAG
Y
V
---
P
----
E
-
F
V
I
Y
---
R
-------
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
----
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
-----------------------------
A
RSGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
-----------
E
C
I
-------
P
A
L
L
F
L
M
L
--
L
-----
Y
--
T
V
------------------
P
E
S
P
R
W
L
M
----
Q
E
Q
A
E
G
I
L
R
K
I
-----
M
G
N
T
---
L
A
T
Q
A
V
Q
E
-
I
K
H
S
L
D
H
G
---------
M
F
G
V
G
V
I
-------
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------------------------
L
L
Q
T
I
-
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
----------
P
L
Q
I
I
G
A
L
G
---
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
----
T
Q
--
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
---
L
-
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
F
V
-
S
W
T
F
P
M
M
DKNSW-------------------------
N
G
F
S
Y
W
--
I
Y
G
C
M
G
V
L
A
A
L
F
M
-
W
K
F
-
V
P
E
T
K
G
K
T
L
EE
L
E
A
L
W
E
------------------
5
PsiBlast_PDB
80.84
20%
-113
- C1 -
4GC0
5
XYLE_ECOLI
A:
[67-479]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
I
----
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVYLAG
Y
V
---
P
----
E
-
F
V
I
Y
---
R
-------
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
----
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
-----------------------------
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
-----------
E
C
I
-------
P
A
L
L
F
L
M
L
--
L
-----
Y
--
T
V
------------------
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
-----
M
G
N
T
---
L
A
T
Q
A
V
Q
E
-
I
K
H
S
L
D
H
G
R
K
T
G
-
G
R
L
L
M
F
G
V
G
V
I
-------
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
-
T
------
L
G
AS
T
---
D
---
I
------
A
L
L
Q
T
I
-
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
----------
P
L
Q
I
I
G
A
L
G
---
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
----
T
Q
--
A
P
G
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
---
L
-
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
F
V
-
S
W
T
F
P
M
M
D
K
N
S
W
L
-
V
--------
A
--------
H
--
F
H
N
G
F
S
Y
W
--
I
Y
G
C
M
G
V
L
A
A
L
F
M
-
W
K
F
-
V
P
E
T
K
G
K
T
L
EE
L
E
A
L
W
E
------------------
3
PsiBlast_PDB
79.79
20%
-114
- C1 -
4GBY
5
XYLE_ECOLI
A:
[67-479]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
I
----
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDNTVPVYLAG
Y
V
---
P
----
E
-
F
V
I
Y
---
R
-------
I
I
G
G
I
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
----
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
-----------------------------
A
R
SGD
A
S
W
L
N
T
D
G
W
R
Y
M
F
A
S
-----------
E
C
I
-------
P
A
L
L
F
L
M
L
--
L
-----
Y
--
T
V
------------------
P
E
S
P
R
W
L
M
S
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
-----
M
G
N
T
---
L
A
T
Q
A
V
Q
E
-
I
K
H
S
L
D
H
G
R
K
T
G
-
G
R
L
L
M
F
G
V
G
V
I
-------
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
-
T
------
L
G
AS
T
---
D
---
I
------
A
L
L
Q
T
I
-
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
----------
P
L
Q
I
I
G
A
L
G
---
M
A
I
G
M
F
S
L
G
T
A
F
-
Y
----
T
Q
--
A
PG
I
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
---
L
-
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
F
V
-
S
W
T
F
P
M
M
D
K
N
S
W
L
-
V
--------
A
--------
H
--
F
H
N
G
F
S
Y
W
--
I
Y
G
C
M
G
V
L
A
A
L
F
M
-
W
K
F
-
V
P
E
T
K
G
K
T
L
EE
L
E
A
L
W
E
------------------
16
Fugue
72.71
12%
-110
- C1 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
FKP
A
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
------
L
V
E
Q
G
F
S
R
G
-------------------------------------------------------------------------------
D
L
G
F
A
L
S
G
I
S
I
A
Y
---
G
F
S
K
F
----
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
L
I
L
A
---
A
A
V
M
L
F
M
G
F
V
P
W
---------------------
A
T
---
S
----
S
-
I
A
V
M
F
V
L
L
-------
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
----
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
-----------------------------
M
------------------
A
-----------
W
------
F
N
D
W
H
A
A
L
Y
M
P
--
A
-----
F
--
C
A
------------------
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
--------------
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
-
K
L
L
W
Y
I
A
I
A
N
V
-------
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
-
T
Y
L
K
E
V
K
H
F
A
L
D
-
K
------
S
S
--
W
---
A
---
Y
------
F
L
Y
E
Y
A
-
G
-
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
R
G
A
----------
T
G
V
F
F
M
T
L
V
---
T
I
A
T
I
--
V
Y
W
M
N
-
P
----
A
G
--
N
--
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
H
---
A
L
E
-
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
---
F
G
Y
L
G
G
-
S
V
A
A
S
A
I
-----
V
-
G
--------
Y
--------
T
--
V
D
F
F
G
W
D
G
--
G
F
M
V
M
I
G
G
S
I
L
A
V
-
I
-
L
-
L
I
V
V
M
I
G
E
K
--
R
R
H
E
Q
L
L
Q
E
L
V
P
------------
22
HHSearch
63.64
15%
-126
- C1 -
1PW4
-
GLPT_ECOLI
A:
[51-431]
---------------------------------------------------------------------------------------------------------------------------------
A
M
P
Y
L
--
V
E
-
Q
G
F
S
---
R
G
D
L
G
F
A
L
S
G
I
---
S
I
A
Y
G
----
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
---------------------
F
V
---
P
W
A
T
S
S
-
I
A
V
M
F
V
L
L
-------
F
L
C
G
W
F
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
K
E
R
----
G
G
I
V
S
V
-
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
AWF-------------------------
N
------------------
D
-----------
W
H
A
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
-
F
-----
A
--
M
M
------------------
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
----------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
-------
W
Y
I
A
I
A
N
V
F
V
Y
L
L
R
-
Y
G
I
L
D
W
S
P
T
Y
L
K
-
E
V-----
K
H
--
F
A
L
D
K
---
S
------
S
W
A
Y
F
L
-
Y
-
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
----------
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
--
I
V
Y
W
M
-
N
----
P
A
--
G
--
N
P
T
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
M
L
I
G
L
---
H
A
L
E
L
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
---
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
-----
G
Y
T
--------
V
D
-------
F
--
F
G
W
D
G
G
F
M
--
V
M
I
G
G
S
I
L
A
V
I
L
L
-
I
-
V
-
V
M
I
G
E
K
R
R
H
--
E
Q
L
L
Q
E
L
V
P
---------------
24
HHSearch
63.39
16%
-119
- C1 -
3WDO
-
?
A:
[33-380]
----------------------------------------------------------------------------------------------------------------------------------
L
T
T
Y
G
M
A
L
-
Q
G
A
S
---
E
A
L
I
G
I
A
I
G
I
Y
---
G
L
T
Q
A
----
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
---------------------
L
S
---
D
----
S
-
I
W
G
I
I
L
G
R
-------
A
L
Q
G
S
G
A
------
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
----
T
K
A
M
A
F
-
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
-----------------------------
T
H
K
L---------------
G
-----------
L
H
A
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
-
I
-----
W
--
V
V
------------------
P
N
S
S
T
H
V
L
N
R
E
-----
S
----------------------------------
G
M
V
K
G
-
S
F
S
K
V
L
A
E
P
R
L
-------
L
K
L
N
F
G
I
M
C
L
H
M
L
L
-
M
S
T
F
V
A
L
P
G
Q
L
A
-
D
------
A
G
--
F
---
P
---
A
A
E
H
W
K
V
Y
L
A
T
M
L
-
I
-
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
------------
V
F
V
F
C
V
G
L
---
I
V
V
A
E
--
I
V
L
W
N
-
A
----
Q
---
T
--
Q
F
W
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
---
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
---
S
Q
F
L
G
V
-
A
I
G
G
S
L
G
-----
G
W
I
--------
D
--------
G
M
-
F
D
G
Q
G
V
F
L
--
A
G
A
M
L
A
A
V
W
L
A
V
A
-
S
-
T
-
M
K
E
P
P
Y
V
S
S
--
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
25
HHSearch
62.13
16%
-100
- C1 -
2GFP
-
EMRD_ECOLI
A:
[29-359]
--------------------------------------------------------------------------------------------------------------------------------
P
A
I
A
D
M
-
A
R
D
-
L
N
V
R
---
E
G
A
V
Q
S
V
M
G
A
Y
---
L
L
T
Y
G
----
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
---------------------
T
T
---
S
----
S
-
L
T
V
L
I
A
A
S
-------
A
M
Q
G
M
G
T
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
----
R
H
A
N
S
L
-
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
-----------------------------
D
TM
W
---------------
N
-----------
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M-
A
-----
R
--
W
M
------------------
P
E
T
R
P
V
D
-------
A
P
R
----------------------------------
T
R
L
L
T
-
S
Y
K
T
L
F
G
N
S
G
F
-------
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
-
A
A
F
E
A
C
S
G
V
L
M
G
A
V
------
L
G
--
L
---
S
S
M
T
V
------
S
I
L
F
I
L
-
P
-
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
----------
M
W
Q
S
V
I
C
C
L
---
L
A
G
L
L
--
M
W
I
P
D
W
F
----
G
V
--
M
--
N
V
W
T
L
L
V
P
A
A
L
F
F
F
G
A
G
M
L
F
P
L
A
T
S
---
G
A
M
E
P
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
G
---
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
-----
A
M
L
--------
P
--------
Q
--
T
G
Q
G
S
L
G
L
--
L
M
T
L
M
G
L
L
I
V
L
C
W
-
L
-
P
-
L
----------------------------------
26
HHSearch
60.73
11%
-116
- C1 -
2CFQ
-
LACY_ECOLI
A:
[28-393]
--------------------------------------------------------------------------------------------------------------------------------
P
F
F
P
I
W
-
L
H
D
I
N
H
I
S
---
K
S
D
T
G
I
I
F
A
A
I
---
S
L
F
S
L
----
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
---------------------
F
G
---
P
----
L
L
Q
Y
N
I
L
V
G
S
-------
I
V
G
G
I
Y
L
G
F
CFNA
G
A
P
A
V
E
A
F
I
E
K
V
S
R
--
R
S
----
N
F
E
F
G
R
-
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
-----------------------------
F
T
I
----------------
N
-----------
N
Q
F
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
--
L
-----
F
--
F
A
------------------
K
T
D
A
P
S
S
--
A
---
T
V
A
N
A
----------
V
-----------------
G
A
N
H
S
A
F
S
L
K
-
L
A
L
E
L
F
R
Q
P
K
L
-------
W
F
L
S
L
Y
V
I
G
V
S
C
T
Y
-
D
V
F
D
Q
Q
F
A
N
F
F
T
-
S
F
FAT
G
E
Q
G
--
T
R
--
V
---
F
------
G
Y
V
T
T
M
-
G
-
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
----------
N
A
L
L
L
A
G
T
I
---
M
S
V
R
I
--
I
G
S
S
F
-
A
----
T
S
------
A
L
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
V
G
C
F
K
---
Y
I
T
S
Q
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
---
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
-----
G
N
M
Y
-------
E
--------
S
--
I
G
F
Q
G
A
Y
L
--
V
L
G
L
V
A
L
G
F
T
L
I
S
-
V
-
F
-
T
L
S
G
P
G
P
L
S
--
L
L
R
R
Q
V
N
E
V
A
--------------
23
HHSearch
52.39
12%
-100
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[45-402]
------------------------------------------------------------------------------------------------------------------------------
N
D
I
L
L
P
Q
F
-
Q
Q
A
-
F
T
L
T
---
N
F
Q
A
G
L
I
Q
S
A
F
---
Y
F
G
Y
F
----
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
---------------------
P
A
A
E
I
M
----
N
-
Y
T
L
F
L
V
G
L
-------
F
I
I
A
A
G
L
G
C
----
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
S
S
G
----
H
F
R
L
N
L
-
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
ILSNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
------------------
S
-----------
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
--
I
-----
M
L
T
K
F
------------------
P
A
L
Q
S
D
-----
N
H
S
D
A
---------------------------------
K
Q
G
S
F
S
A
-
S
L
S
R
L
A
R
I
R
H
W
-------
R
W
A
V
L
A
Q
F
C
Y
V
G
A
Q
-
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I-----
P
G
--
M
---
T
A
G
F
A
------
A
N
Y
L
T
G
-
T
-
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
P
H
----------
K
V
L
A
A
Y
A
L
I
---
A
M
A
L
C
--
L
I
S
A
F
-
A
----
G
---
G
---
H
V
G
L
-
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
P
T
I
F
S
---
L
G
I
K
N
L
G
Q
D
T
K
-
Y
G
S
S
F
I
--
V
---
M
T
I
I
G
G
-
G
I
V
T
P
V
M
-----
G
-
F
--------
V
--------
S
--
D
A
A
G
N
I
P
T
--
A
E
L
I
P
A
L
C
F
A
V
I
F
-
I
-
F
-
A
R
F
R
S
Q
T
----------------------------
9
PsiBlast_PDB
45.78
25%
-119
- C1 -
4ZOW
1
?
A:
[52-187]
------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
---
L
A
G
G
M
----
F
L
Q
W
L
L
G
P
L
S
D
R
I
G
R
R
P
V
M
L
A
G
---
V
V
W
F
I
V
T
C
L
A
I
L
---------------------
L
A
---
Q
----
N
-
I
E
Q
F
T
L
L
R
-------
F
L
Q
G
I
S
L
C
F
----
I
G
A
V
G
Y
A
A
I
R
E
S
F
E
E
A
V
C
I
K
I
T
A
L
M
A
N
V
-
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
V
L
-----------------------------
P
------------------
W
-----------
E
G
M
F
V
L
F
A
A
L
A
A
I
S
F
F
G
L
--
Q
-----
R
--
A
M
------------------
P
E
T
A
T
R
I
G
E
K
L
S
L
K
E
L
G
R
D
Y
K
L
V
L
K
N
G
R
F
V
A
G
A
L
A
L
G
F
V
S
L
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
-
G
E
Q
L
S
S
Y
E
Y
G
L
-------
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
-
L
L
A
R
L
T
S
R
R
T
V
R
-
S
------
L
I
--
I
---
M
---
G
------
G
W
P
I
M
I
-
G
-
L
L
V
A
A
A
A
T
V
I
S
S
H
A
Y
L
W
M
T
A
G
----------
L
S
I
Y
A
F
G
I
G
---
L
A
N
A
G
--
L
V
R
L
T
-
L
----
F
A
--
S
--
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
I
---
S
K
H
A
W
L
N
G
G
N
G
L
F
N
L
F
N
L
-
V
N
---
G
I
L
W
L
S
-
L
M
V
I
F
L
K
-------------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.29
25%
-117
* C1 *
4ZP0
1
?
A:
[53-188]
------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
---
L
A
G
G
M
----
F
L
Q
W
L
L
G
P
L
S
D
R
I
G
R
R
P
V
M
L
A
G
---
V
V
W
F
I
V
T
C
L
A
I
L
---------------------
L
A
---
Q
----
N
-
I
E
Q
F
T
L
L
R
-------
F
L
Q
G
I
S
L
C
F
----
I
G
A
V
G
Y
A
A
I
R
E
S
F
E
E
A
V
C
I
K
I
T
A
L
M
A
N
V
-
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
V
L
-----------------------------
P
------------------
W
-----------
E
G
M
F
V
L
F
A
A
L
A
A
I
S
F
F
G
L
--
Q
-----
R
--
A
M
------------------
P
E
T
A
T
R
I
G
E
K
L
S
L
K
E
L
G
R
D
Y
K
L
V
L
K
N
G
R
F
V
A
G
A
L
A
L
G
F
V
S
L
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
-
G
E
Q
L
S
S
Y
E
Y
G
L
-------
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
-
L
L
A
R
L
T
S
R
R
T
V
R
-
S
------
L
I
--
I
---
M
---
G
------
G
W
P
I
M
I
-
G
-
L
L
V
A
A
A
A
T
V
I
S
S
H
A
Y
L
W
M
T
A
G
----------
L
S
I
Y
A
F
G
I
G
---
L
A
N
A
G
--
L
V
R
L
T
-
L
----
F
A
--
S
--
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
I
---
S
K
H
A
W
L
N
G
G
N
G
L
F
N
L
F
N
L
-
V
N
---
G
I
L
W
L
S
-
L
M
V
I
F
L
K
-------------------------------------------------------------------------------------------
11
PsiBlast_PDB
45.23
25%
-121
- C1 -
4ZP2
1
?
A:
[53-188]
------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
---
L
A
G
G
M
----
F
L
Q
W
L
L
G
P
L
S
D
R
I
G
R
R
P
V
M
L
A
G
---
V
V
W
F
I
V
T
C
L
A
I
L
---------------------
L
A
---
Q
----
N
-
I
E
Q
F
T
L
L
R
-------
F
L
Q
G
I
S
L
C
F
----
I
G
A
V
G
Y
A
A
I
R
E
S
F
E
E
A
V
C
I
K
I
T
A
L
M
A
N
V
-
A
L
I
A
P
L
L
G
P
L
V
G
A
A
W
I
H
V
L
-----------------------------
P
------------------
W
-----------
E
G
M
F
V
L
F
A
A
L
A
A
I
S
F
F
G
L
--
Q
-----
R
--
A
M
------------------
P
E
T
A
T
R
I
G
E
K
L
S
L
K
E
L
G
R
D
Y
K
L
V
L
K
N
G
R
F
V
A
G
A
L
A
L
G
F
V
S
L
P
L
L
A
W
I
A
Q
S
P
I
I
I
I
T
-
G
E
Q
L
S
S
Y
E
Y
G
L
-------
L
Q
V
P
I
F
G
A
L
I
A
G
N
L
-
L
L
A
R
L
T
S
R
R
T
V
R
-
S
------
L
I
--
I
---
M
---
G
------
G
W
P
I
M
I
-
G
-
L
L
V
A
A
A
A
T
V
I
S
S
H
A
Y
L
W
M
T
A
G
----------
L
S
I
Y
A
F
G
I
G
---
L
A
N
A
G
--
L
V
R
L
T
-
L
----
F
A
--
S
--
D
M
S
K
G
T
V
S
A
A
M
G
M
L
Q
M
L
I
F
T
V
G
I
E
I
---
S
K
H
A
W
L
N
G
G
N
G
L
F
N
L
F
N
L
-
V
N
---
G
I
L
W
L
S
-
L
M
V
I
F
L
K
-------------------------------------------------------------------------------------------
31
HHSearch
42.45
15%
-99
- C1 -
2CFQ
-
LACY_ECOLI
A:
[258-392]
--------------------------------------------------------------------------------------------------------------------------------------------------
T
R
V
F
G
Y
V
T
T
M
G
---
E
L
L
N
A
----
S
I
M
F
F
A
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
---------------------
F
A
---
T
----
S
-
A
L
E
V
V
I
L
K
-------
T
L
H
M
F
E
V
P
F
----
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
R
F
S
----
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
F
M
S
V
L
A
G
N
M
-----------------------------
Y
------------------
E
S
I
G--------
F
Q
G
A
Y
L
V
L
G
L
V
A
L
G
F
T
L
I
--
S
-----
V
--
F
T
------------------
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
41.95
15%
-90
- C1 -
3O7Q
1
FUCP_ECOLI
A:
[44-174]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
I
L
L
P
Q
F
Q
Q
-
A
------
F
T
--
L
---
T
N
F
Q
A
------
G
L
I
Q
S
A
-
F
-
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
----------
A
G
I
I
T
G
L
F
L
---
Y
A
L
G
A
--
A
L
F
W
P
-
A
----
A
E
I
-
M
--
N
Y
T
L
F
L
V
G
L
F
I
I
A
A
G
L
G
C
L
E
T
A
A
N
P
---
F
V
T
V
L
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
---
F
N
S
F
G
A
-
I
I
A
V
V
F
G
-----
Q
-
S
--------
L
--------
I
--
L
S
N
V
P
H
Q
S
--
Q
D
V
L
D
K
M
S
P
E
Q
L
S
-
A
-
Y
-
K
H
S
L
V
L
S
V
Q
--
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
27
HHSearch
40.49
10%
-102
- C1 -
3WDO
-
?
A:
[48-187]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------
G
I
A
I
G
I
-
Y
-
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
----------
P
L
I
V
G
G
L
A
V
---
F
A
A
G
S
--
V
I
A
A
L
-
S
----
D
S
------
I
W
G
I
I
L
G
R
A
L
Q
G
S
--
G
A
I
A
A
A
V
M
A
---
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
---
S
F
G
I
T
F
-
A
I
A
M
V
L
G
-----
P
I
I
--------
T
H
-------
K
--
L
G
L
H
A
L
F
W
--
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
-
V
-
V
P
N
S
S
T
H
V
L
--
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
28
HHSearch
39.84
15%
-109
- C1 -
1PW4
-
GLPT_ECOLI
A:
[65-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
------
G
F
A
L
S
G
-
I
-
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
----------
V
F
L
P
A
G
L
I
L
---
A
A
A
V
M
--
L
F
M
G
F
-
V
----
P
W
A
T
S
--
S
I
A
V
M
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
W
P
P
C
G
R
---
T
M
V
H
W
W
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
C
---
A
H
N
V
G
G
-
G
I
P
P
L
L
F
-----
L
L
G
--------
M
--------
A
WF
N
D
W
H
A
A
L
Y
--
M
P
A
F
C
A
I
L
V
A
L
F
A
-
F
-
A
-
M
M
R
D
T
P
Q
S
C
--
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N