@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S35B4_HUMAN: (2015-12-10 )
MRPALAVGLVFAGCCSNVIFLELLARKHPGCGNIVTFAQFLFIAVEGFLFEADLGRKPPAIPIRYYAIMVTMFFTVSVVNNYALNLNIAMPLHMIFRSGSLIANMILGIIILKKRYSIFKYTSIALVSVGIFICTFMSAKQVTSQSSLSENDGFQAFVWWLLGIGALTFALLMSARMGIFQETLYKRFGKHSKEALFYNHALPLPGFVFLASDIYDHAVLFNKSELYEIPVIGVTLPIMWFYLLMNIITQYVCIRGVFILTTECASLTVTLVVTLRKFVSLIFSILYFQNPFTLWHWLGTLFVFIGTLMYTEVWNNLGTTKSEPQKDSKKN
Atome Classification :
(15 SA)
---------------.........10........20.---.......-----30..-.------..--...--.40.....-------------------...50--..-.......60------.........70....------------------.---...80......--------..90...-.....100------.-------......110.......120-------.--.--......130---------.....-...140..-------....--------------.150....----------..----..160-.----------------------.--------------.....170-------------........180......--.190...-....200...------..----..210.-......220.......230.....-----..--240.......250--------.-----.-------------------------.....260.--......270........280.......290-------------------------.........300...--------..-----------..310....-..--------.320.......330---------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------MRP
A
L
A
V
G
L
V
F
A
G
C
C
S
N
V
I
F
L
E
---
L
L
A
RKHP-----G-CG-
N
------
I
V
--
T
F
A
--
Q
F
L
F
I
A
V
E
-------------------
G
F
L
F
---EA-DLGRKPPA-------
I
P
I
R
Y
Y
A
I
M
V
T
M
F
F
T
------------------
V
---
S
VVN
N
Y
A
L
N
L
N
--------IA
M
P
L
H
M
-
I
FRS
G
S
L
I
------
A
-------
N
M
I
L
G
I
I
I
L
KKR
Y
S
I
F
K
Y
--------
T
--
S
--
I
A
L
V
S
V
G
I
----------
F
I
C
T
F
-
M
S
A
K
QVTS-------QSSL--------------SE-ND
G
F
Q
----------
A
F
----
V
W
W
L
L
-
G
----------------------
I
--------------
G
A
L
T
F
A
L
--------------
L
M
S
A
R
M
G
I
F
Q
E
T
L
Y
K
R
F
--GKHSK
E
A
-
L
F
YNHALPL
P
------
G
F
----
V
F
L
A
S
D
-IYDH
A
V
LFNKSE
L
Y
EIPVIG
V
T
L
P
-----
I
M
--
W
F
Y
L
L
M
N
I
I
T
Q
Y
V
--------
C
-----I-------------------------
R
G
V
F
I
L
TTE--CA
S
L
T
V
T
-
L
V
V
T
L
R
K
F
V
S
L
I
F
S
I
L
Y
FQN---------------------------
P
F
T
L
W
H
W
L
G
T
L
F
V
F
I
--------
G
T
-----------
L
M
Y
T
E
V
W
N
N-LG--------TTKSEPQKDSKKN----------------------------------------------
15
Fugue
85.10
14%
-151
- C2 -
2F7F
4
?
A:
[4-485]
--TYADDSLTLHTD
M
Y
Q
I
N
M
M
Q
T
Y
W
E
L
G
R
A
D
L
H
A
V
F
E
---
C
Y
F
R
E
M
P
-----
F
-
N
H
-
G
------
Y
A
--
I
F
A
G
L
E
R
L
V
N
Y
L
E
-------------------
N
L
T
F
T
E
S
D
I
-
A
Y
L
R
E
V
E
E
-------
Y
P
E
D
F
L
T
Y
L
A
N
F
E
F
K
C
T
V
R
S
A
L
EG
D
L
V
F
N
NEPL
I
---
Q
I
E
G
P
L
A
Q
C
Q
L
--------
V
E
T
A
L
L
N
-
M
V
N
F
Q
T
L
I
------
A
-------
T
K
A
A
R
I
K
S
V
I
G
D
D
P
L
L
E
F
GTRRAQE
L
D
--
A
--
A
I
W
G
T
R
A
A
----------
Y
I
G
G
A
-
D
A
T
S
N
V
R
A
-------
G
K
I
F
G
I
P
V
S
G
T
H
A
H
S
L
V
Q
S
Y
-
G
N
D
Y
E
----------
A
F
----
M
A
Y
A
K
-
T
----------------------
H
R
D
C
V
F
LVDTYDTLK
A
G
V
P
S
A
I
--------------
R
V
A
R
E
M
G
D
K
I
N
F
L
G
V
R
I
DS
G
D
M
A
Y
I
S
-
K
R
V
R
E
Q
L
D
E
A
------
G
F
TE
A
K
I
Y
A
S
N
D
-
L
D
E
N
T
I
L
N
L
K
M
Q
K
S
K
I
D
V
W
G
V
G
T
K
-----
L
I
T
A
Y
D
Q
P
A
L
G
A
V
F
K
L
V
--------
S
-----
I
E
G
EDG
Q
M
K
D
T
I
K
L
S
SNAEKVTTPGK
K
Q
V
W
R
I
T
R
K
--
S
D
K
K
S
E
G
-
D
Y
V
T
L
W
N
E
D
P
R
Q
E
E
E
I
Y
M
F
H
---------------------------
P
V
H
T
F
I
N
K
Y
V
R
D
F
E
A
--------
R
P
-----------
V
L
Q
D
I
F
V
E
G
-
K
R
--------
V
Y
E
L
P
T
L
D
E
I
K
Q
Y
A
K
E
N
L
D
S
LHEEYKRDLNPQKYPVDLS
T
D
C
W
N
H
K
M
N
L
L
E
K
V
R
K
D
V
KH
14
Fugue
79.40
18%
-156
* C5 *
4PE2
1
MALE_ECOLI
A:
[3-498]
IEEG
K
L
V
I
W
I
N
GDKG
Y
N
G
L
A
E
V
G
K
K
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
K
L
E
E
K
F
P
-----
Q
-
V
A
-
A
T
GDGPD
I
I
--
F
W
A
--
H
D
R
F
G
G
Y
A
Q
S
GLL
A
E
I
T
P
D
K
A
F
Q
D
K
L
Y
P
F
T
W
---
D
A
V
R
Y
N
G
K
L
I
A
-------
Y
P
I
A
V
E
A
L
--
S
L
I
Y
N
------------------
K
---
D
L
L
P
N
P
P
K
T
W
E
--------
E
I
P
A
L
D
K
-
E
L
K
A
K
G
K
S
------
A
LMFNLQE
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
A
F
K
Y
--------
E
NG
K
--
Y
D
I
K
D
V
G
V
DN
A
G
A
K
A
G
L
T
F
L
V
D
L
-
I
K
N
K
H
M
N
A
-------
D
T
D
Y
--------------
S
I
A
E
A
A
F
N
K
GETA
M
T
I
N
G
P
W
----
A
W
S
N
I
-
D
T
S
KVN
Y
G
V
T
V
L
P
T
F
KGQPSK
P
F
V
--------------
G
V
L
S
A
G
I
--------------
N
A
A
S
P
N
K
E
L
A
K
E
F
L
E
N
Y
--
L
L
T
D
E
G
L
-
E
A
V
N
K
D
K
P
L
-------
G
A
----
V
A
L
K
S
Y
-
E
E
E
L
A
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
NIPQ
M
S
A
--
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
GRQT
V
D
E
A
-----
L
-------------------------
K
D
A
Q
T
N
A
A
A
SN
I
N
K
A
K
V
A
-
S
V
E
S
D
Y
S
S
V
K
S
A
A
L
S
Y
Y
S
D
K
NTMPPSGELDALETYMDTLPDKADI
G
G
G
Y
K
L
L
L
V
N
N
K
L
A
L
K
I
--------
G
D
GTAA
D
S
V
T
L
T
K
A
Q
I
E
K
L
L
S
D
-
I
G
PKKIYTEN
T
L
K
T
E
L
Q
K
N
S
T
L
K
DG
T
L
Y
I
V
LIDN-----------------------------------
20
Fugue
78.66
17%
-128
- C5 -
4O2X
-
MALE_ECOLI
A:
[5-483]
--EG
K
L
V
I
W
I
N
GDKG
Y
N
G
L
A
E
V
G
K
K
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
K
L
E
E
K
F
P
Q
V
A
A
T
G
-
D
G
P
D
------
I
I
F
W
A
H
D
--
R
F
G
G
Y
A
Q
S
-------------------
G
L
L
A
---
E
I
-
T
P
D
K
A
F
Q
D
K
L
Y
P
F
T
W
D
A
V
R
Y
N
G
K
L
I
A
Y
P
I
A
------------------
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
PPKTWEE
I
P
A
L
D
K
E
L
-
K
A
K
G
K
S
A
L
MFNLQE
P
-------
Y
F
T
W
P
L
I
A
A
D
G
G
Y
A
-
F
K
Y
--------
E
--
N
GK
Y
D
I
K
D
V
G
V
DN
A
G
A
K
A
G
L
T
F
L
V
D
L
-
I
K
N
K
H
M
N
A
DTD
Y
S
I
A
E
A
A
F
--------------
N
K
-
G
E
T
A
M
----------
T
I
N
G
PW
A
W
S
N
I
-
D
----------------------
T
--------------
S
K
V
N
Y
G
V
T
V
L
P
T
F
KGQPSK
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
--
A
K
E
F
L
E
N
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
KPL
G
A
----
V
A
L
K
S
Y
-
E
E
E
L
A
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
NIPQ-
M
S
--
A
F
W
Y
A
V
R
T
A
V
I
N
A
--------
A
S
GRQT
V
-------------------------
D
E
A
L
A
A
A
Q
T
--
N
A
A
A
N
L
E
-
K
I
K
K
L
R
N
V
I
T
S
A
W
K
V
I
L
Y
N
D
---------------------------
D
I
H
N
F
T
Y
V
T
D
V
I
V
K
V
V
GQIS
K
A
K
A
H
-----------
T
I
T
V
E
A
H
S
T
G
Q
A
--------
L
I
L
S
T
W
K
S
K
A
E
K
Y
C
Q
E
L
Q
Q
N
G
L
T
V
S
I
I
H
ES-----------------------------
5
HHSearch
47.73
12%
-167
- C- -
3B5D
1
EMRE_ECOLI
A:
[32-105]
---------------------------------------------------------------------------------------------------------------------------------
P
S
V
G
T
I
I
C
Y
C
A
------------------
S
---
F
W
L
L
A
Q
T
L
A
Y
---------
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
V
------
L
-------
I
S
L
L
S
W
G
F
F
G
Q
R
L
D
L
P
A
I
--------
I
--
G
--
M
M
L
I
C
A
G
V
----------
L
I
I
N
L
-
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
42.68
9%
-174
- C- -
3B5D
1
EMRE_ECOLI
A:
[43-105]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
F
-------------------------
W
L
L
A
Q
T
L
A
Y
--
I
P
T
G
I
A
Y
A
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
Q
---------------------------
R
L
D
L
P
A
I
I
G
M
M
L
I
C
A
--------
G
V
-----------
L
I
I
N
L
L
S
------------------------------------------------------------------------
16
Fugue
40.21
38%
153
* C4 *
4TTL
-
A:
[1-22]
---------------------------
G
C
C
S
D
----
P
---
R
C
N
Y
D
H
P
-----
E
I
C
G
-
G
------
A
A
--
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
Fugue
39.71
16%
8
- C4 -
4RS7
-
?
A:
[1-87]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
E
----------
S
L
Y
R
A
M
P
S
I
K
K
L
V
D
-------
E
G
K
L
--------------
T
E
-
K
D
A
E
K
----------
V
Y
----
E
I
W
R
N
M
E
----------------------
A
--------------
I
Y
K
Q
A
S
L
--------------
L
W
Y
N
T
V
D
L
L
L
K
R
I
--
G
L
--
S
E
K
E
R
E
E
-
I
F
Y
------------------------
E
M
V
R
P
Y
F
R
L
F
S
R
E
E
V
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
36.23
24%
-26
- C4 -
1RPN
2
GM4D_PSEAE
A:
[180-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
G
L
H
A
S
S
G
-
I
L
F
N
H
E
S
P
L
R
------
G
I
----
E
F
V
T
R
K
-
V
T
D
A
V
A
R
I
K
L
G
K
Q
Q
E
L
R
L
G
N
V
D
A
K
-----
R
D
--
W
G
F
A
G
D
Y
V
E
A
M
W
L
--------
M
-----
L
-------------------------
Q
Q
D
K
A
D
D
Y
V
--
V
A
T
G
V
T
T
-
T
V
R
D
M
C
Q
I
A
F
E
H
V
G
L
D
Y
R
D
F
---------------------------
L
K
I
D
P
A
F
F
R
P
A
E
V
D
V
--------
L
L
-----------
G
N
P
A
K
A
Q
R
V
-
L
G
--------
W
K
P
R
T
S
L
D
E
L
I
R
M
----------------------------------------------
1
PsiBlast_PDB
35.51
30%
28
* C3 *
1LQA
1
TAS_ECOLI
A:
[220-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
V
--------------
S
Q
-
Y
E
G
V
E
----------
L
L
----
A
Y
S
C
L
-
G
----------------------
F
--------------
G
T
L
T
G
K
Y
--------------
L
N
G
A
K
P
A
G
A
R
N
T
L
F
S
R
F
--
T
R
Y
S
G
E
Q
-
T
Q
K
A
V
A
A
Y
V
D
------
I
A
----
R
R
H
G
L
D
-
P
A
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
-----
M
D
--
Q
L
K
T
N
I
E
S
L
H
L
E
L
--------
S
-----
E
-------------------------
D
V
L
A
E
I
E
A
V
--
H
Q
V
Y
T
Y
P
-
A
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
32.13
22%
165
- C3 -
1IYJ
-
DSS1_HUMAN
A:
[6-63]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
V
D
-------
L
G
L
L
--------------
E
E
-
D
D
E
F
E
----------
E
F
----
P
-------------------------------------------
H
V
W
E
D
N
W
--------------
D
D
D
N
V
E
D
D
F
S
N
Q
L
R
A
E
L
--
E
K
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
26.37
8%
-20
- C4 -
2I68
-
EMRE_ECOLI
A:
[42-104]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------
S
-----
F
-------------------------
W
L
L
A
Q
T
L
A
-------
I
A
Y
A
I
W
S
G
V
G
I
V
L
I
S
L
L
S
W
G
F
F
G
---------------------------------
A
I
I
G
M
M
L
I
C
A
--------
G
V
-----------
L
I
I
N
L
L
-------------------------------------------------------------------------
11
Fugue
26.21
26%
678
- C1 -
4PVZ
-
?
D:
[6-37]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
K
R
-
K
R
--------
E
Q
I
S
S
P
K
K
K
R
K
K
R
----------------------------------------------
7
HHSearch
17.05
7%
90
- C4 -
3RKO
-
?
J:
[133-160]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
G
P
---------------------------
Y
V
L
A
V
E
L
A
S
M
L
L
L
A
G
--------
L
V
-----------
V
A
F
H
V
G
R
E
E
-
R
A
--------
G
E
V
L
-------------------------------------------------------
9
HHSearch
11.29
17%
330
- C4 -
2JP3
-
FXYD4_RAT
A:
[24-41]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
G
L
L
C
I
A
--------
G
I
-----------
A
L
A
L
S
G
K
C
K
-
C
R
--------
R
N
H
T
P
S
S
L
P
E
K
V
T
----------------------------------------------
10
HHSearch
10.96
11%
411
- C4 -
3WGU
1
?
G:
[34-48]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
A
F
I
V
--------
G
L
-----------
I
I
I
L
S
K
-------------------------------------------------------------------------