@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S38AB_HUMAN: (2015-12-10 )
MKQAGFPLGILLLFWVSYVTDFSLVLLIKGGALSGTDTYQSLVNKTFGFPGYLLLSVLQFLYPFIAMISYNIIAGDTLSKVFQRIPGVDPENVFIGRHFIIGLSTVTFTLPLSLYRNIAKLGKVSLISTGLTTLILGIVMARAISLGPHIPKTEDAWVFAKPNAIQAVGVMSFAFICHHNSFLVYSSLEEPTVAKWSRLIHMSIVISVFICIFFATCGYLTFTGFTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPMECFVTREVIANVFFGGNLSSVFHIVVTVMVITVATLVSLLIDCLGIVLELNGVLCATPLIFIIPSACYLKLSEEPRTHSDKIMSCVMLPIGAVVMVFGFVMAITNTQDCTHGQEMFYCFPDNFSLTNTSESHVQQTTQLSTLNISIFQ
Atome Classification :
(20 SA)
----------------------------------------------......------...10........20........30--------....-....40....--....-----50--.-........----60-..---...---...70......------------------.-----.80....-------....-------------90........-----------100.....------...110-...----....-----------.120----...---------......130--------.--........140.......150.......160.-------.....--.170--------.----.....-.-180---------..---------....------...190.....----..200-........210.--......220....-----------..-------.230...-.--...240.--------------------------------------------..-....-------250.....-------..--------260------........270...----..-----..------280--.....----------------------------------....290----......-.300...----....310..--.....320---..-......330.-----------.-----------------.-.-..---------.340....---...350...-----.---...360-----...------------.--------...370.....-------..380-----..-----.......390.....----.--.400....-----------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------MKQAGF------
P
L
G
I
L
L
L
F
W
V
S
Y
VTD
F
S
L
V
L
L
I
KGG--------ALSG-
T
D
T
Y
Q
S
L
V
N
K--TFGF-----
P
---
G
-
Y
L
L
L
S
V
L
Q
----
F
L
-
Y
P
---
F
I
A
---
M
I
S
Y
NIIA
G
D
T
------------------
L
-----
S
K
V
F
Q
RI-------PGVD-------------PE
N
V
F
I
G
R
H
F
-----------
I
I
-
G
L
S
T
V
------
T
F
T
L
P
--
L
S
L
----
Y
R
N
I
-----------
A
K
------LG
K
---------
V
S
L
I
S
T
G
----------
L
--
T
T
L
I
L
G
I
V
M
A
R
A
I
SLGPHIPKTED
A
W
V
F
AKPN-------A
I
Q
A
V
--
G
V
M
S
--------
F
----
A
F
I
C
H-H-N-----------
S
F
---------
L
V
Y
S------SLEE
P
T
V
A
K
W
S
----
R
L
I
H
--
M
S
I
V
I
S
V
F
I
C
I
F
--
F
A
TCG
Y
L
T
FTGFT-----------Q
G
-------
D
L
F
E
N
Y
C-R--NDD
L
V
T
F
--------------------------------------------
G
R
-
F
C
Y
G
-------
V
T
V
I
L
TY
P
-------
M
E
--------
C
F
-------
V
T
R
E
V
I
A
N
V
FFGG
N
----
L
S
-----
S
V
------
F
----
H
I
V
V
T
----------------------------------
V
M
V
I
T
V
A
----
T
L
V
S
L
L
-
I
D
C
L
G
I
V
----
L
ELNG
V
L
CA--T
P
L
I
F
I
I----PS-
A
C
Y
L
KLSEEP-----------R-----------------T-
H
-
S
D
---------
K
I
M
S
C
V
M
L
---
P
I
G
A
V
V
M
V
F
-----
G
---
F
V
M
A
IT-----NTQ------------D--------CTHG
Q
E
M
F
Y
CF-------PDN-------FS-----LTNT
S
E
S
H
V
Q
Q
T
T
Q
L
----
S
--
T
L
N
I
S
IFQ-----------------------------------------------
21
Fugue
83.81
19%
-128
- C2 -
4GA6
1
AMPPA_THEKO
A:
[1-493]
-----------------------M
K
A
K
I
R
I
L
DMFSGRY
T
V
L
I
N
E
E
D
A
K
E
A
K
L
------
H
P
D
D
L
V
K
I
E
A
G
K
K
A
V
Y
G
S
V
A
L
-
S
N
L
--------
V
G
K
G
-
E
V
G
I
S
R
D
V
L
D
--
L
H
N
F
-----
S
---
E
-
G
E
T
V
S
V
I
P
----
A
G
-
T
P
---
E
S
V
---
R
Y
I
K
K
K
M
H
G
E
K
------------------
L
R
K
V
E
I
E
A
I
V
R
D
I
-------
V
D
R
K
-------------
L
R
D
I
E
I
-
S
S
F
-----------
V
T
-
A
L
E
I
N
------
G
L
D
M
D
E
I
A
A
L
----
T
I
A
M
-----------
A
E
------
T
G
D
M
L
D
I
DRKP
I
M
D
V
H
S
I
G
GVPGNK----
T
--
N
I
L
V
V
P
I
V
A
A
A
----
G
L
T
I
P
K
T
S
S
R
A
I
T
S
A
A
G
-------
T
A
D
V
V
--
E
V
F
A
DVSFS
L
D
E
I
----
K
R
I
V
E
-
K
V
G
-----------
A
C
---------
L
V
W
G
GALNLA
P
A
D
D
I
T
I
K
A
E
R
----
A
L
S
I
DP
T
G
L
M
L
A
S
I
M
S
K
K
--
Y
A
M
G
S
Q
Y
V
L
I
D
I
P
-----------
T
G
KGVKVE-
T
V
E
E
A
R
S
-
L
--
A
R
D
F
I
E
L
--------------------------------------------
G
K
R
L
G
Q
Y
-------
V
E
V
A
I
T
Y
G
-------
G
Q
PIGHTVGP
A
L
-------
E
A
R
E
A
L
S
A
L
M
T
G
K
G
----
P
-----------------------
G
----------------------------------
S
L
I
E
K
A
T
----
G
L
A
G
I
L
-
L
E
M
G
G
V
A
----
P
A
G
T
G
K
K
M
A
--
K
E
I
L
E
------
S
G
-
K
A
W
E
K
M
K
E
I
I
-----------
E
-----------------
A
-
Q
G
G
D
---------
P
N
I
K
P
E
E
I
---
P
I
G
D
K
T
Y
T
F
T
AA
T
S
G
---
Y
V
T
A
I
D
-----
N
R
A
I
T
A
I
A
R
A
A
GAPE
D
--------
K
G
A
G
I
E
L
Y
V
K
V
-------
G
E
K
V
K
EGDPL
F
T
-----
I
H
A
E
H
E
A
R
L
D
Q
A
I
V
L
----
A
--
R
R
T
E
P
I
R
I
E----------------------------------------------
22
Fugue
78.40
18%
-140
* C5 *
4PE2
1
MALE_ECOLI
A:
[3-498]
IEEG
K
L
V
I
W
I
N
GDKG
Y
N
G
L
A
E
V
G
K
K
F
E
K
D
TG
I
K
V
T
V
E
H
P
D
K
L
E
E
K
F
P
Q
V
A
A
T
------
G
D
G
P
D
I
I
F
W
A
----
H
D
R
F
G
G
Y
A
Q
S
G
--------
L
L
A
E
-
I
T
P
D
K
A
F
Q
D
K
L
Y
P
F
T
W
-----
D
---
A
-
V
R
Y
N
G
K
L
I
----
A
--
Y
P
---
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
------------------
P
-----
P
K
T
W
E
E
I
-------
P
A
L
D
-------------
K
E
L
K
A
K
G
K
S
A
-----------
L
M
F
N
L
Q
E
P
------
Y
F
T
W
P
--
L
I
A
A
D
G
G
Y
A
F
K
-----------
Y
E
------
N
G
K
---------
Y
D
I
K
D
V
G
----------
V
DN
A
G
A
K
A
G
L
T
F
L
V
D
L
I
K
N
K
H
M
N
A
D
T
D
-
Y
S
I
A
E
A
A
-------
F
N
K
G
E
--
T
A
M
T
--------
I
N
G
PW
A
W
S
N
I
-
D
-
T
-----------
S
K
---------
V
N
Y
G
------
V
T
V
L
P
T
F
--------------
K
G
Q
P
S
K
P
F
V
G
V
L
--
S
A
G
I
N
A
A
S
P
N
K
E
L
-----------
A
K
-------
E
F
L
E
N
Y
L
L
T
--
D
E
G
L
E
A
V
--------------------------------------------
N
K
D
K
P
L
G
-------
A
V
A
L
K
S
Y
E
-------
E
E
--------
L
A
KD
P
----
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
----
M
P
NIPQ
M
S
A
------
F
----
W
Y
A
V
R
----------------------------------
T
A
V
I
N
A
A
S
GRQ
T
V
D
E
A
L
-
K
D
A
Q
T
N
A
AASN
I
N
K
A
K
V
A
S
V
--
E
S
D
Y
S
S
V
----
K
S
-
A
A
L
S
Y
Y
S
D
K
N
TMPPSGELDAL
E
-----------------
T
-
Y
-
M
D
---------
T
L
P
D
K
A
D
I
---
G
G
G
Y
K
L
L
L
V
-----
N
---
N
K
L
A
L
K
I
G
DGT
A
A
D
------------
S
--------
V
T
L
T
K
A
Q
I
E
K
L
-------
L
S
D
-------
I
G
PKKIY
T
E
N
T
L
K
T
E
L
Q
K
N
S
T
L
----
K
DG
T
L
Y
I
V
L
I
D
N----------------------------------------------
23
Fugue
76.97
17%
-135
- C4 -
4Q86
1
YCAO_ECOLI
A:
[2-583]
------------------------T
Q
T
F
I
P
GKDAA
L
E
D
S
I
A
R
F
Q
Q
K
L
S
D
L
G
F
Q
I
E
EAS
W
L
N
P
V
P
N
V
W
S
V
H
I
R
D
K
E
C
A
L
C
F
T
N
G
K
G
AT
K
K
A
A
L
A
S
A
-
L
G
E
Y
F
E
R
L
S
T
--
N
Y
F
F
-----
A
---
D
-
F
W
L
G
E
T
I
A
N
GPF
V
H
-
Y
P
N
E
K
W
F
P
---
L
T
E
N
D
D
V
P
E
G
L
------------------
L
-----
D
D
R
L
R
A
F
-------
Y
--
D
-------------
P
E
N
E
L
T
G
S
M
L
IDLQSGNEDR
G
I
C
-
G
L
P
F
T
RQSDN
Q
T
V
Y
I
P
--
M
N
I
----
I
G
N
L
YVSNG
M
S
A
GNT
R
N
------
E
A
R
---------
V
Q
G
L
S
E
V
----------
F
--
E
R
Y
V
K
N
R
I
I
A
E
S
I
S
L
-
P
E
I
P
A
D
V
L
A
R
Y
P
A
V
V
E
-------
A
I
E
T
L
--
E
A
E
G
--------
F
----
P
I
F
A
Y
-
D
-
G
-----------
S
L
GGQYP
V
I
C
V
V
L
F
N
------
P
A
N
G
T
C
F
A
S
F
G
----
A
H
P
D
--
F
G
V
A
L
E
R
T
V
T
E
L
--
L
Q
G
R
G
L
K
D
L
D
V
F
T
PPTFD
D
E
E
V
A
E
H
T
-------
N
L
E
T
H
F
I
-
D
--
S
S
G
L
I
S
W
--------------------------------------------
D
L
-
F
-----------
K
Q
D
A
D
Y
P
-------
F
V
--------
D
W
NFSGT
T
E
E
E
F
A
T
L
M
A
I
F
N
K
E
D
K
E
V
Y
I
A
-----
D
Y
------
E
----
H
L
G
V
Y
----------------------------------
A
C
R
I
I
V
P
----
G
M
S
D
I
Y
P
A
E
D
L
W
L
A
----
N
N
S
M
G
S
H
L
R
--
E
T
I
L
S
L
P
GSEW
E
K
-
E
D
Y
L
N
L
I
E
Q
L
-----------
D
E
E
GFDDFTR
V
R
E
L
L
GLA
T
-
G
-
S
D
NGWYTLR
I
G
E
L
K
A
M
L
A
L
A
G
G
D
L
E
Q
A
L
V
W
T
-----
E
---
W
T
M
E
F
N
-----
S
S
V
------------
F
--------
S
P
E
R
A
N
Y
Y
R
C
L
-------
Q
T
L
-------
L
L
-----
L
A
Q
E
E
D
R
Q
P
L
Q
Y
L
N
A
----
F
--
V
R
M
Y
G
A
D
A
V
E
A
A
S
A
A
M
S
GEAAFYGLQPVDSDLHAF
A
A
H
Q
S
L
L
K
A
Y
E
K
L
Q
R
A
K
A
A
F
25
Fugue
72.78
15%
-125
- C5 -
4IA6
12
?
A:
[1-591]
--------------------------------M
Y
Y
S
N
G
N
Y
E
A
F
A
D
P
K
K
P
A
G
V
------
D
K
K
S
A
Y
I
I
G
S
G
L
A
G
L
S
T
A
V
F
L
V
R
D
A
--------
Q
M
K
G
-
E
N
I
H
I
L
E
E
L
P
--
V
A
G
F
-----
V
VR
G
G
-
R
E
M
E
N
H
F
E
----
C
L
-
W
D
---
M
Y
R
---
S
I
P
S
L
E
V
P
G
A
S
------------------
Y
-----
L
D
E
Y
Y
W
L
-------
D
K
E
D
-------------
P
-
N
S
S
N
C
R
L
I
-----------
Y
N
-
R
G
D
R
L
------
P
S
D
G
Q
--
Y
G
L
----
G
K
C
A
-----------
N
E
------
I
V
K
---------
L
I
M
T
P
E
K
E---------
I
--
E
G
Q
T
I
E
E
F
F
S
D
E
F
F
K
T
N
F
W
T
Y
W
S
T
M
F
A
F
E
K
W
H
-------
S
L
A
E
M
--
R
R
Y
A
--------
M
----
R
F
I
H
H
-
I
-
D
GLPDFTA
L
K
F
N
K
Y
---------
N
Q
Y
E
------
S
M
V
K
P
L
L
A
Y
L
K
D
H
G
V
Q
F
E
Y
--
D
C
H
V
K
N
V
E
V
D
H
E
--
G
D
S
K
I
A
K
K
I
V
M
T
Q
-----------
N
G
-------
K
D
K
E
I
D
L
-
T
--
H
N
D
I
V
F
V
TNGSITES
S
T
Y
G
D
QNTPAPITNAKG
D
S
W
K
L
W
E
N
L
A
K
Q
DPAFGHP
D
V
-
F
C
E
N
LPERSWF
V
S
A
T
A
T
L
E
NKKL
A
P
Y
F
E
--------
R
L
-------
T
K
R
S
L
Y
D
G
K
V
N
T
G
G
----
I
I
-----
T
I
VDSN--
W
----
E
L
S
F
T
I
H
RQPHFKSQNPD
Q
I
V
V
W
I
Y
A
LYSDTEGNYIKKR
I
V
D
C
T
G
K
----
E
I
A
E
E
L
-
L
Y
H
L
G
V
P
----
E
S
Q
I
S
E
L
A
S
--
E
E
N
M
N
T
V
----
P
V
Y
M
P
Y
I
T
S
Y
F
M
P
-----------
R
-----------------
R
-
D
-
G
D
---------
R
P
D
---
V
V
---
P
E
G
S
I
N
L
A
F
-----
I
---
G
N
F
A
E
S
-----
P
T
R
------------
D
TVFT
T
E
Y
S
V
R
T
A
M
E
A
V
Y
T
L
L
NVDRGV
P
E
V
-------
F
D
-----
S
I
Y
D
I
R
Q
L
L
R
A
M
Y
Y
M
S
DKK
K
--
L
A
D
Q
D
M
P
L
P
E
K
L
A
V
K
T
G
M
R
K
I
KKT
W
V
E
E
L
L
K
E
A
NLV-------------------
7
HHSearch
68.91
13%
-139
* C6 *
3L1L
2
ADIC_ECO57
A:
[41-403]
-----------------------------------------------------------
I
A
I
Y
G
W
L
V
T
I
I
G
A
L
G
L
S
M
V
Y
A
K
M
S
--------
F
L
D
P
S
P
G
G
S
Y
A
Y
A
R
R
--
C
F
G
P
-----
F
---
L
-
G
Y
Q
T
N
V
L
Y
----
W
L
-
A
C
---
W
I
G
---
N
I
A
M
V
V
I
G
V
G
Y
------------------
L
-----
S
Y
F
F
P
I
L
-------
K
--
D
-------------------
P
W
V
L
-----------
T
I
-
T
C
V
V
V
------
L
W
I
F
V
--
L
L
N
----
I
V
G
P
-----------
K
M
------
I
T
R
---------
V
Q
A
V
A
T
V
----------
L
--
A
L
I
P
I
V
G
I
A
V
F
G
W
F
W
F
R
G
E
T
Y
-
M
A
-------
A
-------
I
Q
S
T
L
--
N
V
T
L
--------
W
----
S
F
I
G
V
-
E
-
S
-----------
A
S
---------
V
A
A
G
------
V
V
K
N
P
K
-
R
N
V
P
----
I
A
T
I
--
G
G
V
L
I
A
A
V
C
Y
V
L
--
S
T
T
A
I
M
G
M
I
P
N
A
A
-----------
L
R
VSASP
F
G
D
A
A
R
M
A
L
----
G
D
T
A
G
A
I
--------------------------------------------
V
S
-
F
C
A
A
-------
A
G
C
L
G
S
L
G
-------
G
W
--------
T
L
-------
L
A
G
Q
T
A
K
A
A
A
D
D
G
L
----
F
P
-----
P
I
FARVNK
A
GTP
V
A
G
L
I
I
----------------------------------
V
G
I
L
M
T
I
----
F
Q
L
S
S
I
-
S
P
N
A
T
K
E
----
F
G
L
V
S
S
V
S
V
I
F
T
L
V
P
Y
L
Y
----
T
C
-
A
A
L
L
L
L
G
H
G
H
-----------
F
-----------------
G
-
K
-
A
----------
R
P
A
Y
L
A
V
T
---
T
I
A
F
L
Y
C
I
W
-----
A
---
V
V
G
S
G
A
-----
K
E
V
------------
M
--------
W
S
F
V
T
L
M
V
I
T
A
-------
M
Y
A
-------
L
N
-----
Y
N
R
L
H
K
N
P
Y
P
L
D
A
----------------------------------------------------------------
26
Fugue
66.01
10%
-133
- C6 -
2A65
6
?
A:
[5-515]
REHWAT
R
L
G
L
I
L
A
M
A
G
N
A
VGLGNFL
R
F
P
V
Q
A
A
E
N
G
G
G
A
F
M
I
P
Y
I
I
A
F
L
L
V
G
I
------
P
L
M
W
I
E
W
A
M
G
R
Y
G
G
A
Q
G
H
G
T
T
P
A
I
F
--------
Y
L
L
W
-
R
----
N
R
F
A
K
--
I
L
G
V
-----
F
---
G
-
L
W
I
P
L
V
V
A
----
I
Y
-
Y
V
---
Y
I
E
---
S
W
T
L
G
F
A
I
K
F
L
V
GL
V
P
E
P
PPTD
P
D
S
I
L
R
P
F
-----
K
E
F
L
Y
S
Y
I
GVPKGD
E
P
I
L
-------------
K
P
S
L
F
A
Y
I
V
F
-----------
L
I
-
T
M
F
I
N
------
V
S
I
L
I
--
R
G
I
----
S
K
G
I
-----------
E
R
------
F
A
K
---------
I
A
M
P
T
L
F
----------
I
--
L
A
V
F
L
V
I
R
V
F
L
L
E
T
P
N
G
T
A
A
D
G
L
N
F
L
W
T
P
D
F
E
KLKD
P
G
V
W
I
A
A
V
--
G
Q
I
F
--------
F
----
T
L
S
L
G
-
F
-
G
-----------
A
I
---------
I
T
Y
A
------
S
Y
V
R
K
D
-
Q
D
I
V
----
L
S
G
L
--
T
A
A
T
L
N
E
K
A
E
V
I
L
G
G
S
I
S
I
P
A
A
V
A
F
F
G
-----------
V
A
-------
N
A
V
A
I
A
K
-
A
--
G
A
F
N
L
G
F
------------------------------------------------------------
I
T
L
P
A
I
-------
F
S
--------
Q
T
-------
A
G
G
T
F
L
G
F
L
W
F
F
L
L
----
F
F
-----
A
G
------
L
----
T
S
S
I
A
----------------------------------
I
M
Q
P
M
I
A
----
F
L
E
D
E
L
-
K
L
S
R
K
H
A
----
V
L
W
T
A
A
I
V
F
--
F
S
A
H
L
V
M
----
F
L
-
N
K
S
L
D
E
M
D
F
W
-----------------------------
A
-
G
-
T
I
---------
G
V
V
F
F
G
L
T
---
E
L
I
I
F
F
W
I
F
-----
G
A
D
K
A
W
E
E
I
N
-----
R
G
G
------------
I
--------
I
K
V
P
R
I
Y
Y
Y
V
M
R
Y
I
T
---
P
A
F
-------
L
A
-----
V
L
L
V
V
W
A
R
E
Y
I
P
K
I
M
----
E
--
E
T
H
W
T
V
W
I
T
R
F
Y
I
I
G
L
F
L
F
L
T
F
L
V
F
L
A
E
R
R
R
N
H
E
S
A
G
T-----------------
24
Fugue
64.77
10%
-111
- C3 -
1CVR
1
CPG2_PORGI
A:
[1-432]
----------------------------------------------
Y
T
P
V
E
E
------
K
E
N
G
R
M
I
V
I
V
A
K
K
Y
E
G
D
I
K
D
F
V
D
W
K
--------
N
Q
R
G
-
L
R
T
E
V
K
V
A
E
D
--
I
A
S
P
VT---
A
---
N
-
A
I
Q
Q
F
V
K
Q
----
E
Y
-
E
K
---
E
G
N
---
D
L
T
Y
V
L
L
V
G
D
H
------------------
K
-----
D
I
P
A
K
I
T
-------
P
G
I
K
S
D
Q
V
Y
G
QIVGNDH
Y
N
E
V
F
I
G
R
F
S
-----------
C
E
-
S
K
E
D
L
------
K
T
Q
I
D
--
R
T
I
----
H
Y
E
R
-----------
N
I
TTEDKW
L
G
Q
---------
A
L
C
I
A
S
A
EGGPSADNGE
S
--
D
I
Q
H
E
N
V
I
A
N
L
L
T
Q
Y
G
Y
T
K
I
I
K
C
Y
D
P
G
V
T
P
K
N
-------
I
I
D
A
F
N
G
G
I
S
L
--------
V
----
N
Y
T
G
H
G
S
-
E
-----------
T
A
---------
W
G
T
S
------
H
F
G
T
T
H
V
K
Q
L
T
----
N
S
N
Q
--
L
P
F
I
F
D
V
---------
A
C
V
N
G
D
F
L
F
-
S
-----------
M
P
-------
C
F
A
E
A
L
M
-
R
--
A
Q
K
D
G
K
P
T-------------------------------------------
G
T
-
V
A
I
I
-------
A
S
T
I
D
Q
Y
W
-------
A
P
--------
P
M
-------
R
G
Q
D
E
M
N
E
I
L
C
E
K
H
----
P
N
-----
N
I
------
K
----
R
T
F
G
G
----------------------------------
V
T
M
N
G
M
F
----
A
M
V
E
K
Y
-
K
K
D
G
E
N
M
----
L
D
T
W
T
V
F
G
D
--
P
S
L
L
V
R
T
----
L
V
-
P
T
E
M
Q
V
T
A
P
A
-----------
N
-----------------
I
S
A
-
S
A
---------
Q
T
F
E
V
A
C
D
---
Y
N
G
A
I
A
T
L
S
-----
D
---
D
G
D
M
V
G
-----
T
A
I
----------------------
V
K
D
G
K
A
I
I
K
L
-------
N
E
S
-------
I
A
-----
D
E
T
N
L
T
L
T
V
V
G
Y
N
K
V
----
T
--
V
I
K
D
V
K
V
E
-----------------------------------------------
8
HHSearch
62.01
13%
-119
- C6 -
3GIA
5
Y609_METJA
A:
[36-309]
------------------------------------------------
I
A
G
R
-------
N
L
P
E
T
F
I
L
S
G
I
Y
A
L
L
V
A
Y
S
Y
T
K
L
G
--------
A
K
I
V
S
N
A
G
P
I
A
F
I
H
K
--
A
I
G
D
-----
N
---
I
I
T
G
A
L
S
I
L
L
----
W
M
-
S
Y
---
V
I
S
---
I
A
L
F
A
K
G
F
A
G
Y
------------------
F
-----
L
P
L
I
N
A
P
-------
I
--
N
-------------------
T
F
N
I
-----------
A
I
-
T
E
I
G
I
------
V
A
F
F
T
--
A
L
N
----
F
F
G
S
-----------
K
A
------
V
G
R
---------
A
E
F
F
I
V
L
----------
V
--
K
L
L
I
L
G
L
F
I
F
A
G
L
I
T
I
H
P
S
Y
V
I
P
D
L
A
P
S
A
V
S
G
-------
M
I
F
A
S
--
A
I
F
F
--------
L
----
S
Y
M
G
F
-
G
-
V
-----------
I
T
---------
N
A
S
E
------
H
I
E
N
P
K
-
K
N
V
P
----
R
A
I
F
--
I
S
I
L
I
V
M
F
V
Y
V
G
--
V
A
I
S
A
I
G
N
L
P
I
D
E
-----------
L
I
K
A
SEN--
A
L
A
V
A
A
K
-
P
FL
G
N
L
G
F
L
L
--------------------------------------------
I
S
-
I
G
A
L
-------
F
S
I
S
S
A
M
N
-------
A
T
--------
I
Y
-------
G
G
A
N
V
A
Y
S
L
A
K
D
G
E
----
L
P
-----
E
F
------
F
----
E
R
K
V
W
----------------------------------
F
K
S
T
E
G
L
----
Y
I
T
S
A
L
-
G
V
L
F
A
L
L
----
F
N
M
E
G
V
A
S
I
--
T
S
A
V
F
M
V
----
I
Y
-
L
F
V
I
L
S
H
Y
I
L
-----------
I
-----------------
D
-
E
-
V
G
---------
G
R
K
E
I
V
I
F
---
S
F
I
V
V
L
G
V
F
-----
L
---
L
L
L
Y
Y
Q
-----
W
I
T
------------
N
--------
R
F
V
F
Y
G
I
I
A
T
F
-------
I
G
V
-------
L
I
-----
F
E
I
I
Y
R
K
V
T
K
R
T
F
S
N
----
N
--
M
Y
V
K
S
--------------------------------------------------
5
PsiBlast_PDB
39.79
34%
1
- C7 -
3DXD
-
APBB1_HUMAN
A:
[612-652]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
A
V
G
R
D
V
H
T
F
-----
A
---
F
I
M
A
A
G
-----
P
A
S
------------
F
--------
C
C
H
---
M
F
W
C
E
-------
P
N
A
-------
A
S
-----
L
S
E
A
V
Q
A
----------------------------------------------------------------------
11
HHSearch
39.12
17%
-79
- C6 -
2XQ2
1
SGLT_VIBPH
A:
[101-204]
-----------------------------------------------------------------------------
Y
F
L
P
I
F
--------
I
E
K
G
-
I
Y
T
I
P
E
F
V
E
K
--
R
F
N
K
-----
K
---
L
-
K
T
I
L
A
V
F
W
----
I
S
-
L
Y
I
--
F
V
N
---
L
T
S
V
L
Y
L
G
G
L
A
------------------
L
-----
E
T
I
L
G
-----------
I
P
---------------------
L
M
-----------
Y
S
-
I
L
G
L
A
------
L
F
A
L
V
--
Y
S
I
----
Y
G
G
--------------------
V
V
W
---------
T
D
V
I
Q
V
F
----------
F
--
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
-------
A
P
G
H
F
--
E
M
I
L
--------
D
----
Q
S
N
P
Q
-
Y
-
M
-----------
N
L
---------
P
G
I
A
------
V
L
I
G
G
L
W
V
A
N
L
----
Y
Y
W
G
--
F
N
Q
Y
I
I
Q
R
T
L
A
A
--
K
S
V
S
E
A
Q
K
G
I
V
F
A
-----------
A
F
-------
L
A
L
I
V
P
F
-
L
--
V
V
L
P
G
I
A
--------------------------------------------
A
Y
-
V
I
T
S
-------
D
P
Q
L
M
A
S
L
-------
G
N
--------
L
P
-------
S
A
A
N
A
D
K
A
Y
P
W
L
T
Q
----
F
L
-----
P
V
------
G
----
V
K
G
V
V
----------------------------------
F
A
A
L
A
A
A
----
I
V
S
S
L
A
-
S
M
L
N
S
T
A
----
T
I
F
T
M
D
I
Y
K
--
E
Y
I
S
P
D
S
----
G
D
-
H
K
L
V
N
V
G
R
T
A
-----------
A
-----------------
V
-
V
-
A
L
---------
I
I
A
A
L
I
A
P
---
M
L
G
G
I
G
Q
C
F
-----
Q
---
Y
I
Q
E
Y
T
-----
G
L
V
------------
S
--------
P
G
I
L
A
V
F
L
L
G
L
-------
F
W
K
-------
K
T
-----
T
S
K
G
A
I
I
G
V
V
A
S
I
P
F
----
A
--
L
F
L
K
F
M
P
L
-----------------------------------------------
4
PsiBlast_PDB
38.06
34%
10
* C7 *
3DXC
-
APBB1_HUMAN
A:
[612-652]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
A
V
G
R
D
V
H
T
F
-----
A
---
F
I
M
A
A
G
-----
P
A
S
------------
F
--------
C
C
H
---
M
F
W
C
E
-------
P
N
A
-------
A
S
-----
L
S
E
A
V
Q
A
----------------------------------------------------------------------
6
PsiBlast_PDB
36.64
34%
6
- C7 -
3DXE
-
APBB1_HUMAN
A:
[612-652]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
A
V
G
R
D
V
H
T
F
-----
A
---
F
I
M
A
A
G
-----
P
A
S
------------
F
--------
C
C
H
---
M
F
W
C
E
-------
P
N
A
-------
A
S
-----
L
S
E
A
V
Q
A
----------------------------------------------------------------------
9
HHSearch
32.77
8%
-74
- C6 -
2JLN
-
?
A:
[63-186]
--------------------------------------------------------------
V
A
I
A
A
G
C
T
I
A
V
I
L
L
F
F
T
Q
S
A
A
--------
I
R
W
--
G
I
N
F
T
V
A
A
R
M
--
P
F
G
I
-----
R
---
G
-
S
L
I
P
I
T
L
K
----
A
L
-
L
S
---
L
F
W
---
F
G
F
Q
T
W
L
G
A
L
A
------------------
L
-----
D
E
I
T
R
L
L
-------
T
G
F
T
-------------------
N
L
P
------------
L
W
-
I
V
I
F
G
------
A
I
Q
V
V
--
T
T
-----
F
Y
G
I
-----------
T
F
------
I
R
W
---------
M
N
V
F
A
S
P
----------
V
--
L
L
A
M
G
V
Y
M
V
Y
L
M
L
D
G
A
D
V
S
L
G
E
V
M
S
M
G
G
E
N
P
G
-------
M
P
F
S
T
--
A
I
M
I
--------
F
----
V
G
G
W
I
-
A
-
V
-----------
V
V
---------
S
I
H
D
------
I
V
K
E
C
K
V
D
P
N
A
----
S
R
E
G
--
Q
T
K
A
D
A
R
Y
A
T
A
Q
--
W
L
G
M
V
P
A
S
I
I
F
G
F
-----------
I
G
-------
A
A
S
M
V
L
V
-
G
--
E
W
N
P
V
I
A
--------------------------------------------
I
T
-
E
V
V
G
-------
G
V
S
I
P
M
A
I
-------
L
F
--------
Q
V
-------
F
V
L
L
A
T
W
S
T
N
P
A
A
N
----
L
L
-----
S
P
------
A
----
Y
T
L
C
S
----------------------------------
T
F
P
R
V
F
T
----
F
K
T
G
V
I
-
V
S
A
V
V
G
L
----
L
M
M
P
W
Q
F
A
G
--
V
L
N
T
F
L
N
----
L
L
-
A
S
A
L
G
P
L
A
G
I
-----------
M
-----------------
I
-
S
-
D
Y
---------
F
L
V
R
R
R
R
I
---
S
L
H
D
L
Y
R
T
K
-----
G
---
I
Y
T
Y
W
R
-----
G
V
N
------------
W
--------
V
A
L
A
V
Y
A
V
A
L
A
-------
V
S
F
-------
L
T
-----
P
D
L
M
F
V
T
G
L
I
A
A
L
L
L
----
H
--
I
P
A
M
R
W
V
A
-----------------------------------------------
13
HHSearch
32.03
13%
-77
- C6 -
2WSW
-
?
A:
[176-225]
---------------------------------------------------------------------------------------------------
P
S
S
T
L
V
P
--
L
V
G
E
K
H
V
N
G
L
---
F
-
G
T
V
V
D
N
F
Y
----
L
V
-
A
L
---
I
L
A
---
M
G
T
S
L
G
L
A
T
P
L
------------------
V
-----
T
E
C
I
Q
Y
L
-------
F
G
I
P
-------------
H
T
L
Q
L
D
A
I
I
I
-----------
S
C
-
W
I
L
L
N
------
A
I
C
V
A
--
F
G
L
----
Q
K
G
V
-----------
K
I
------
A
S
D
---------
V
R
T
Y
L
S
F
----------
L
--
M
L
G
W
V
F
I
V
G
G
A
S
F
I
V
N
Y
F
T
D
S
V
G
T
L
L
M
Y
M
P
R
M
-------
L
F
Y
T
D
--
P
I
G
K
--------
G
----
G
F
P
Q
A
-
W
-
T
-----------
V
F
---------
Y
W
A
W
------
W
V
I
Y
A
I
Q
M
S
I
F
----
L
A
R
I
--
S
K
G
R
T
V
R
E
L
C
L
G
--
M
V
S
G
L
T
A
G
T
W
L
I
W
-----------
T
I
-------
L
G
G
N
T
L
Q
-
L
--
I
D
Q
N
I
L
N
--------------------------------------------
I
P
-
Q
L
I
D
-------
Q
Y
G
V
P
R
A
I
-------
I
E
--------
T
W
-------
A
A
L
P
L
S
T
A
T
M
W
G
F
F
----
I
L
-----
C
F
------
I
----
A
T
V
T
L
----------------------------------
I
N
A
C
S
Y
T
----
L
A
M
S
T
C
-
R
S
M
K
E
G
A
----
D
P
P
L
L
V
R
I
G
--
W
S
V
L
V
G
I
----
I
G
-
I
I
L
L
A
L
G
G
L
K
-----------
P
-----------------
I
-
Q
-
T
A
---------
I
I
A
G
G
C
P
L
---
F
F
V
N
I
M
V
T
L
-----
S
---
F
I
K
D
A
K
-----
V
H
W
------------
K
------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
30.66
45%
-18
* C8 *
3JRU
-
AMPA_XANOR
B:
[138-172]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
----
Y
R
Y
T
-----------
A
T
------
L
G
K
---------
K
K
V
D
E
T
G
----------
L
--
T
T
L
A
I
A
G
D
D
A
R
A
L
A
V
G
V
A
T
A
E
G
V
E
F
A
R
E
L
G
N
L
-------
P
P
N
Y
C
--
T
P
A
Y
--------
L
----
A
D
T
A
A
-
A
-
F
-----------
A
G
---------
K
F
P
G
------
A
E
A
E
I
L
D
E
A
Q
M
----
E
A
L
G
--
M
G
S
L
L
S
V
A
R
G
S
A
--
N
R
P
R
L
I
V
L
K
W
N
G
G
-----------
G
D
-------
A
R
P
Y
V
L
V
-
G
--
K
G
I
T
F
D
T
--------------------------------------------
G
G
-
V
N
L
K
-------
T
Q
G
G
I
E
E
M
-------
K
Y
--------
D
M
-------
C
G
G
A
T
V
I
G
T
F
V
A
T
V
----
K
A
-----
E
L
------
P
----
I
N
L
V
V
----------------------------------
V
V
P
A
V
E
N
----
A
I
D
G
N
A
-
Y
R
P
S
D
V
I
----
T
S
M
S
G
K
T
I
E
--
V
G
N
T
D
A
E
----
G
R
-
L
I
L
C
D
A
L
T
Y
A
-----------
E
-----------------
R
-
F
-
N
P
---------
E
A
L
V
D
V
A
T
---
L
T
G
A
C
M
V
A
L
-----
G
---
H
Q
T
A
G
L
-----
M
S
K
------------
H
--------
D
D
L
A
N
E
L
L
A
A
G
-------
E
H
V
-------
F
D
-----
R
A
W
R
L
P
L
W
D
E
Y
Q
G
L
L
----
D
--
S
T
F
A
D
V
Y
N
-----------------------------------------------
10
HHSearch
29.92
19%
-53
- C6 -
3DH4
-
?
A:
[107-175]
------------------------------------------------------------------------------
F
L
P
I
F
--------
I
E
K
G
-
I
Y
T
I
P
E
F
V
E
K
--
R
F
N
K
-----
K
---
L
-
K
T
I
L
A
V
F
W
----
I
S
L
Y
I
---
F
V
N
---
L
T
S
V
L
Y
L
G
G
L
A
------------------
L
-----
E
T
I
L
G
-----------
I
P
---------------------
L
M
-----------
Y
S
-
I
L
G
L
A
------
L
F
A
L
V
--
Y
S
I
---------------------------
V
V
W
---------
T
D
V
I
Q
V
F
----------
F
--
L
V
L
G
G
F
M
T
T
Y
M
A
V
S
F
I
G
G
T
D
G
W
F
A
G
V
S
K
M
V
D
A
-------
A
P
G
H
F
--
E
M
I
L
--------
D
----
Q
S
N
P
Q
-
Y
-
M
-----------
N
L
---------
P
G
I
A
------
V
L
I
G
G
L
W
V
A
N
L
----
Y
Y
W
G
--
F
N
Q
Y
I
I
Q
R
T
L
A
A
--
K
S
V
S
E
A
Q
K
G
I
V
F
A
-----------
A
F
-------
L
K
L
I
V
P
F
-
L
--
V
V
L
P
G
I
A
--------------------------------------------
A
Y
-
V
I
T
S
-------
D
P
Q
L
M
A
S
L
-------
G
D
--------
I
A
-------
A
T
N
L
P
S
A
A
N
A
D
K
A
Y
----
P
W
-----
L
T
------
Q
----
F
L
P
V
G
----------------------------------
V
K
G
V
V
F
A
----
A
L
A
A
A
I
-
V
S
S
L
A
S
M
----
L
N
S
T
A
T
I
F
T
--
M
D
I
Y
K
E
Y
----
I
S
-
P
D
S
G
D
H
K
L
V
N
-----------
V
-----------------
G
-
R
-
T
A
---------
A
V
V
A
L
I
I
A
---
C
L
I
A
P
M
L
G
G
-----
I
---
G
Q
A
F
Q
Y
-----
I
Q
E
------------
Y
--------
T
G
L
V
S
P
G
I
L
A
V
-------
F
L
L
-------
G
L
-----
F
W
K
K
T
T
S
K
G
A
I
I
G
V
V
----
A
--
S
I
P
F
A
L
F
L
-----------------------------------------------
16
HHSearch
28.59
6%
57
- C6 -
2WWB
-
SC61G_CANFA
B:
[21-54]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
------
R
C
T
K
P
D
R
K
E
F
Q
----
K
I
A
M
--
A
T
A
----
I
G
F
A
I
--
M
G
F
I
G
F
F
V
K
L
I
H
I
-----------
P
I
-------
N
N
I
I
V
G
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
27.30
31%
525
- C7 -
3PP4
-
P:
[3-18]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
C
E
-------
P
A
N
-------
P
S
-----
E
K
N
S
P
S
T
Q
Y
C
Y
S
I
Q
---------------------------------------------------------------
15
HHSearch
24.91
18%
82
- C6 -
3MP7
-
SECE_PYRFU
B:
[17-51]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
L
------
V
T
K
K
P
N
W
A
T
Y
K
----
R
A
A
K
--
I
T
G
----
L
G
I
I
L
--
I
G
L
I
G
M
L
I
R
I
V
G
I
-----------
L
I
-------
L
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
21.76
60%
379
- C1 -
4NZQ
1
?
A:
[108-127]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
Q
E
N
F
C
-
R
--
N
P
D
S
S
T
T
--------------------------------------------
G
P
-
W
C
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------