@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S39AC_HUMAN: (2015-12-10 )
MCFRTKLSVSWVPLFLLLSRVFSTETDKPSAQDSRSRGSSGQPADLLQVLSAGDHPPHNHSRSLIKTLLEKTGCPRRRNGMQGDCNLCFEPDALLLIAGGNFEDQLREEVVQRVSLLLLYYIIHQEEICSSKLNMSNKEYKFYLHSLLSLRQDEDSSFLSQNETEDILAFTRQYFDTSQSQCMETKTLQKKSGIVSSEGANESTLPQLAAMIITLSLQGVCLGQGNLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQRKQNNIITHDQDYSNFSSSMEKESEDGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFKQMSPGIIQQLLSCSCHLPKDQQAKLPPTTLEKYGYSTVAVTLLTLGSMLGTALVLFHSCEENYRLILQLFVGLAVGTLSGDALLHLIPQVLGLHKQEAPEFGHFHESKGHIWKLMGLIGGIHGFFLIEKCFILLVSPNDKQGLSLVNGHVGHSHHLALNSELSDQAGRGKSASTIQLKSPEDSQAAEMPIGSMTASNRKCKAISLLAIMILVGDSLHNFADGLAIGAAFSSSSESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMKTAILMNFISSLTAFMGLYIGLSVSADPCVQDWIFTVTAGMFLYLSLVEMLPEMTHVQTQRPWMMFLLQNFGLILGWLSLLLLAIYEQNIKI
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------...-------..--....10.......------.20......---..30........40........50........60........70-.........80.-.......90........100.......110.......120.......130...---....140.......150..-......160.......170.......180..--...---..190....---.--.-.200.----......210-----....-.....220.-----...------...-230.....---------------..240--.---......-250---.......-.260.......270.......280.......290.-----------......300.......310...---....320.........330-.........340.----.....------.350-......---..360.......370.......380......-..390-......----------..400.......---410......------------.--.420.......430.......440.......------450.......460.......470.......480.......490.......500-.......510.......520.--......530---.........540.......550.......560.......----------------------570.......580.......590....-----...---------600.......610.......620.......630....------...640.....--..650-------......--.660.......670--------....------..----..680.......690---------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MC
F
-------
R
T
--
K
LS
V
S
W
V
P
L
F
L
L
L
------
S
R
V
FSTETD---KPSAQDSRSRGSSGQ
P
A
D
L
L
Q
V
L
SAGDHPPHN
H
S
R
S
L
I
K
T
L
L
E
--KTGCPRRRNGMQ-GDC
N
L
C
FEP
D
A
L
L
L
I
AGG
N
F
E
D
Q
L
R
E
E
V
V
Q
R
V
S
L
L
L
L
Y
Y
I
I
H
Q
E
E
I
C
S
S
KLNM---SN
K
E
Y
K
F
Y
L
H
S
L
L
S
L-RQD-ED
S
S
FLSQNE
T
E
D
I
L
A
F
T
R
Q
Y
FDT
S
Q
S
Q
C
M
E
--
T
K
T
---
L
Q
K
KSGIVS---S--E-GANE
S
----
T
L
P
Q
L
A
A
-------
M
I
I
T
-
L
S
L
Q
G
V
C
LG-----QGN------LP
S
-
P
D
Y
F
T
E
Y
I
---------------
F
S
SLN--R---TNTL
R
L
-
S
E
----
L
D
Q
L
L
N
T
-
L
W
T
R
S
TCIK
N
E
K
I
H
Q
F
Q
R
KQNNIITHDQDY
S
N
F
S
S
-----------
S
MEKESEDGPV
S
W
D
Q
T
C
F
S
A
R
Q
---
L
V
E
I
F
--
L
Q
K
G
L
S
L
I
S
K
---
E
D
F
K
QM
S
P
G
I
I
Q
Q
----
L
L
S
CS------CHL--PKDQQA---KLP
P
T
T
L
E
K
YG
Y
S
T
V
A
V
T
L
L
T
L
G
-
S
M
L
G
T
A
L
-
V
L
F
H
--SC
E
E
N
Y
----------
R
L
I
L
Q
L
F
V
G
L
A
V
---G-TL
S
G
D
A
L
------------
L
--
H
L
I
P
Q
V
L
G
L
H
K
QEAPEFGHFHESKG
H
I
W
K
L
M
------
G
L
I
G
G
I
H
G
F
F
L
I
E
K
C
F
I
L
L
VSPNDKQG
L
S
L
VNGHVGH
S
H
H
L
A
LNSELSDQAGR-GKSA
S
T
I
Q
LKSPEDSQAAEMP--IGSMTAS-----NRKC
K
A
I
S
L
L
A
I
M
I
L
VGD
S
L
H
N
FADG
L
A
I
G
A
A
FSSSSES----------------------G
V
T
T
T
I
A
I
L
C
H
EI
P
H
E
MG
D
F
A
V
L
L
SSG-----L
S
M
---------
K
T
A
I
L
M
N
F
I
S
S
L
T
A
F
M
G
L
Y
I
G
L
SVSA
D
P
C
V
Q
D
W
I
F
T
V
------
T
A
G
M
F
L
Y
L
S
L
V
--
E
M
L
P
E
-------
M
T
HVQT--QR
P
W
M
M
F
L
L
Q
N
F
G
---------
L
I
L
G
------
W
L
----
S
L
L
L
L
A
I
Y
E
QNIKI----------------------------------------------
27
Fugue
89.94
16%
-59
- C1 -
3W3W
1
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
VQDDLPAW
P
E
L
L
Q
A
L
I
E
S
L
K
SGN
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
VD
I
N
S
I
L
P
I
F
Q
S
G
F
T
DAS
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
LPKSEWSKLGIL
L
P
S
L
L
N
S
L
P
R
F
L
D
D
GK
D
D
A
L
A
S
V
F
-------
E
S
L
I
E
L
V
E
L
A
P
K
L
F
K
D
M
------
F
D
Q
I
I
Q
F
T
D
---
M
V
I
K
N
K
D
L
E
P
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
--
V
T
L
I
M
M
T
E
V
S
I
D
D
D
D
A
A
E
W
I
E
S
D
D
T
D
--
D
E
E
E
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
L
G
G
E
Y
L
A
A
P
L
F
Q
Y
L
Q
Q
M
I
---
T
S
T
E
W
R
E
R
F
A
A
M
M
A
L
-
S
S
A
A
E
G
C
A
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
N
D
P
H
P
R
V
Q
Y
G
C
C
N
V
---
L
G
Q
I
S
T
D
F
S
P
F
I
Q
--
R
-
T
A
H
D
R
----
I
L
P
A
L
I
S
K
L
TSECT
S
R
V
Q
-
T
H
A
A
A
A
L
V
N
-----
F
S
E
------
F
A
S
-
K
D
I
L
E
P
Y
L
---------------
D
S
L
L
T
--
N
---
L
L
V
L
L
Q
-
S
N
K
L
Y
V
Q
E
Q
A
L
T
T
-
I
A
F
I
A
E
A
A
K
N
K
F
I
K
Y
Y
D
T
L
M
P
L
L
L
N
V
L
K
V
N
S
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
A
V
G
K
E
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
SD
A
L
R
S
Y
--
L
E
Q
S
W
S
R
I
C
R
I
L
G
D
D
F
V
P
L
L
P
I
V
I
P
P
----
L
L
I
T
A
K
ATQDV
G
L
I
--
E
E
E
E
A
A
NFQ
Q
Y
P
D
W
D
V
V
Q
V
Q
G
K
H
I
A
I
H
T
S
V
L
D
-
D
K
V
-
S
A
M
-
E
L
L
Q
--
S
Y
A
T
L
L
----------
R
G
Q
F
A
V
Y
V
K
E
V
M
---
E
-
E
I
A
L
P
S
L
D
FYLH
D
G
V
R
A
A
G
A
--
T
L
I
P
I
L
L
S
C
L
L
A
A
E
E
L
V
L
L
W
H
K
A
S
S
---
K
L
I
------
G
G
L
M
S
E
P
M
P
E
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
G
D
N
C
L
S
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
-
M
Q
D
R
D
E
Y
N
E
D
F
T
D
E
D
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
GHY
L
K
N
L
E
N
I
W
P
M
I
N
T
F
L
L
E
P
I
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
Y
E
Q
T
A
S
MKNAF
I
P
K
V
T
E
C
L
ISPD
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
Y
A
P
S
T
Y
A
D
V
C
I
P
T
L
D
T
-----
L
V
Q
I
V
DGSKLEE
N
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
N
--
S
N
I
P
D
T
Y
T
A
N
W
F
K
T
L
PTITD
K
E
A
A
S
F
N
Y
Q
F
L
S
--
Q
V
C
A
Q
SN
I
S
A
V
V
D
S
V
I
Q
A
--
L
N
E
R
S
L
T
V
I
S
S
V
K
---------
K
L
L
G
------
F
L
P
S
S
D
A
M
A
I
F
N
R
Y
P
A
D
I
M
E
K
V
H
K
W
F----------------------------------------
21
Fugue
87.18
20%
-70
- C1 -
4NNB
-
?
A:
[4-527]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
S
L
Y
I
T
A
A
P
I
GA
V
P
K
F
-------
L
D
--
P
F
E
A
T
F
I
P
S
F
L
L
-------
E
G
F
F
D
A
D
R
C
---
A
S
I
A
A
D
L
K
T
D
G
--------
W
E
V
V
P
A
G
G
R
L
L
Q
V
G
H
A
Q
P
I
A
H
F
-------------------------
P
K
P
W
L
A
--------
A
L
S
N
K
L
A
R
R
I
V
L
Q
L
T
T
Y
----
G
W
I
V
S
E
Q
G
D
L
L
W
E
H
E
R
Q
H
H
Y
L
P
P
A
L
I
E
A
-
I
E
K
-
E
S
P
A
L
L
K
N
M
E
E
A
G
W
I
A
C
A
A
G
Y
W
Q
-------------------------------
A
-
G
K
A
R
S
------
P
Y
L
P
-------------------------------------
I
T
-
P
E
A
I
T
E
E
T
---------------
I
R
S
M
R
--
A
---
G
A
A
-----------------------------
V
V
H
L
----------
H
T
R
D
L
S
----------------------------
D
R
R
R
I
E
I
P
G
---
L
G
V
V
T
--
V
G
S
Q
R
N
Q
I
V
L
---
D
D
Y
D
A
I
V
P
M
V
K
K
R
EPA
A
I
L
N
L
S
------
T
S
V
--
R
G
D
R
H
G
---
A
R
S
K
L
R
R
A
H
L
K
F
Y
D
D
V
G
S
A
P
E
V
A
-
S
L
S
P
A
A
V
-
V
F
Q
G
G
G
G
Y
D
N
A
P
----------
D
F
L
D
A
Q
F
D
H
F
E
R
V
--
G
-
T
R
P
E
V
E
V
------------
F
N
H
A
I
V
D
N
A
T
S
L
Y
R
D
R
L
L
R
T
G
-------------------------------
K
P
V
L
F
M
L
V
A
G
V
D
Q
Y
R
R
D
P
I
T
G
E
V
E
D
D
S
L
I
A
----------
R
-
V
V
R
E
E
I
S
S
L
L
A
D
E
S
-------------
A
D
S
-----
H
R
R
A
V
E
L
A
I
G
Q
L
R
P
V
V
E
R
L
R
A
S
F
P
---------------------------------------
V
S
K
I
S
I
L
---
L
P
G
P
M
Q
N
L
L
V
D
V
A
L
G
-----
L
G
L
----------
D
G
I
R
V
G
L
E
D
G
L
T
V
N
D
A
R
V
P
G
G
V
R
K
A
R
------------------
G
T
W
E
Q
V
S
L
V
R
E
E
L
L
G
R
-------
G
A
T
I
L
T
------
A
A
Q
V
R
D
M
F
G
---------
L
G
I
-------------------------------------------------------------------------
28
Fugue
77.14
16%
-41
- C1 -
4A0G
2
BIODA_ARATH
A:
[27-831]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
F
H
L
P
LN
H
P
T
Y
L
I
W
S
ANTSLG
K
T
--
L
V
S
T
G
I
A
A
S
F
L
L
Q
------
Q
P
S
S
S
A
T
K
L
L
Y
L
K
P
I
Q
T
G
F
P
S
D
S
D
S
R
F
V
F
S
K
L
D
S
L
S
L
R
R
Q
I
P
I
S
I
S
N
S
V
L
H
S
S
L
P
A
A
K
S
L
G
L
N
V
E
V
S
E
S
-
G
M
C
S
L
N
F
R
D
E
K
-----------
T
V
T
G
A
P
E
L
L
C
K
T
L
Y
A
W
E
A
A
I
S
P
H
L
A
A
E
R
E
N
A
---
T
V
E
D
S
V
V
L
Q
M
I
E
K
C
L
-
K
E
E
-
M
D
--
L
L
C
L
V
E
T
A
G
G
V
A
S
P
G
P
---
S
G
T
L
Q
C
D
L
--
Y
R
P
---
F
R
L
P
G
I
L
V
G
---
D
GR
L
-
G
G
I
S
G
----
T
I
A
A
Y
E
S
-------
L
K
L
R
G
Y
D
I
A
A
V
V
F
E
-----
D
H
G
------
L
V
N
-
E
V
P
L
T
S
Y
L
RNK
V
P
V
L
V
L
P
P
VPKD
P
S
D
D
L
--
I
---
E
W
F
V
E
S
-
D
G
----
V
F
K
A
L
K
E
-
T
M
V
L
A
N
L
E
R
L
E
R
L
N
G
M
A
K
L
A
G
E
V
F
W
W
P
F
T
Q
H
K
L
V
H
-----------
Q
E
T
V
T
V
I
D
S
R
C
G
E
N
F
S
I
Y
K
A
S
D
---
N
--
S
S
--
L
S
Q
Q
F
D
A
C
A
S
---
W
W
T
Q
G
P
D
P
T
F
Q
A
E
----
L
A
R
E
M
------
G
Y
T
--
A
A
R
F
G
H
---
V
M
F
P
E
N
V
Y
E
P
A
L
K
C
A
E
L
L
L
D
G
V
G
-
K
--
G
W
A
S
-
R
V
Y
F
--
S
--
D
N
G
----------
S
T
A
I
E
I
A
L
K
M
A
F
---
R
-
K
F
C
V
D
H
N
---------------
F
I
V
V
K
V
I
A
L
R
-------
G
S
Y
H
---
G
D
T
L
G
A
M
E
A
QAPS
P
Y
T
G
F
L
Q
Q
P
W
Y
T
G
R
G
L
F
L
-----
D
P
P
T
V
F
L
S
N
G
----
S
W
N
I
S
L
P
E
S
F
S
E
I
A
P
E
Y
G
T
F
T
S
R
D
E
I
F
D
K
S
R
D
A
S
T
L
A
R
--
I
Y
S
A
Y
L
S
-----
K
H
L
A
H
V
G
A
L
I
I
E
P
V
I
H
G
A
G
G
M
H
M
V
D
P
L
F
Q
R
V
L
V
N
E
C
R
N
R
K
I
P
V
I
F
DEVFTGFWRL------
G
V
E
T
T
T
E
L
L
--
G
C
K
P
D
I
A
C
F
A
K
L
L
T
G
G
M
V
P
L
A
V
T
L
---------
A
T
D
A
V
F
D
S
F
S
G
D
S
K
L
K
A
L
L
H
G
H
S
Y
S
A
----
H
A
M
G
C
A
T
------
A
A
K
A
I
Q
W
F
K
D
P
--
E
T
N
H
N
-------
I
T
S
Q
G
K
TL
R
E
L
W
D
E
E
L
V
Q
Q
I
S
S
HSAVQ
R
V
V
V
I
G
T
------
L
F
----
A
L
E
L
K
S
L
Y
A
K
S
L
L
I
M
L
R
E
D
G
I
F
T
R
P
LGN
V
I
Y
L
M
C
G
PCTS
P
E
I
C
R
R
L
L
T
K
L
Y
K
R
L
G
E
F
NRT
22
Fugue
75.48
16%
-62
* C2 *
4BHW
1
EP300_HUMAN
A:
[14-576]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K
K
I
F
K
-------
P
E
--
E
L
R
Q
A
L
M
P
T
L
E
A
L
Y
R
QDPE
S
L
P
F
R
Q
P
V
D
---
P
Q
L
L
G
I
P
D
Y
F
D
I
V
K
S
P
M
D
L
S
T
I
K
R
K
L
D
T
G
Q
Y
Q
E
P
W
Q
Y
V
D
D
I
W
L
--
M
F
N
N
A
W
L
Y
N
R
K
T
-
S
------
R
V
Y
K
Y
C
S
K
L
S
E
V
F
E
Q
E
I
D
P
V
M
Q
S
------
L
G
Y
C
------
C
G
R
K
L
E
F
---
S
P
Q
T
L
C
C
Y
G
K
Q
L
C
T
I
-
P
R
D
---
A
T
Y
Y
S
Y
Q
N
R
---
Y
H
F
C
E
K
C
F
N
E
I
Q
G
E
------------------------------------------------------
S
-
V
S
L
------------
G
D
------
D
P
S
-
Q
P
Q
T
T
I
N
K
---------------
E
Q
F
S
K
--
R
---
K
N
D
T
L
D
-
P
E
----
L
-------
F
V
E
C
T
E
C
--
G
R
K
M
H
Q
I
C
V
L
H
H
E
I
I
-
W
P
A
G
F
V
C
D
G
C
-----------
L
K
K
S
A
R
T
R
K
E
N
K
F
S
A
K
R
L
P
S
T
R
---
L
G
T
F
L
--
E
N
R
V
N
D
F
L
R
R
---
Q
N
H
P
E
S
G
E
V
T
V
R
V
----
V
H
A
S
D
------
K
T
V
E
V
K
P
G
M
K
A
---
R
F
V
D
S
G
E
M
A
E
S
F
P
Y
R
T
K
A
L
F
A
F
E
-
E
I
D
G
V
D
L
-
C
F
F
G
--
M
H
V
Q
E
Y
G
SDCPPPNQR
R
V
Y
I
S
Y
L
D
S
V
H
F
FRP
K
-
C
L
R
T
A
V
Y
------------
H
--
E
I
L
I
G
Y
L
E
Y
V
K
K
L
G
Y
-------
T
T
G
H
I
W
A
C
P
------
P
S
E
G
D
---------
D
Y
I
F
H
C
H
P
P
D
Q
K
----------
I
P
K
P
K
R
L
Q
E
W
F
K
K
M
L
D
K
-
A
V
S
E
R
I
V
H
D
Y
K
D
I
F
K
Q
A
T
E
D
R
--
L
T
S
-------------------------
A
K
E
L
P
Y
F
E
G
D
F
W
P
N
V
L
E
E
S
I
K
E
S
----------------------
G
G
S
G
S
Q
K
L
Y
A
T
M
E
K
H
K
E
V
F
F
V
I
R
L
I
A
G
-----
P
A
A
---------
N
S
L
P
P
I
-----------------
V
D
P
D
P
----------------------
L
I
P
C
--
D
L
M
D
G
----------------
R
D
A
F
L
T
L
A
R
D
K
H
---------
L
E
F
S
S
L
R
R
A
Q
W
S
----
T
M
C
M
L
V
E
L
H
T
Q
S
Q
D
----------------------------------------------
3
PsiBlast_PDB
54.04
25%
19
- C3 -
3APW
1
A1AG2_HUMAN
A:
[51-177]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
T
P
N
K
T
E
D
T
I
-
F
L
R
E
Y
-
Q
T
R
Q
N
Q
C
F
Y
--
N
S
S
Y
L
N
V
Q
R
E
N
G
T
V
S
---
R
Y
-
E
-
G
G
R
E
--------
H
V
A
H
-------
L
L
F
L
-
R
D
T
K
T
L
M
F
G
S
YLDD
E
K
N
W
G
L
S
F
Y
A
D
K
-
P
E
T
T
K
E
Q
L
---------------
G
E
F
Y
E
--
A
---
L
D
C
L
R
I
-
P
R
----
S
D
-
V
M
Y
T
-
D
W
K
K
D
K
C
E
P
L
E
K
Q
H
E
K
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
53.51
25%
17
- C3 -
3APV
2
A1AG2_HUMAN
A:
[51-173]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
T
P
N
K
T
E
D
T
I
-
F
L
R
E
Y
-
Q
T
R
Q
N
Q
C
F
Y
--
N
S
S
Y
L
N
V
Q
R
E
N
G
T
V
S
---
R
Y
-
E
-
G
G
R
E
--------
H
V
A
H
-------
L
L
F
L
-
R
D
T
K
T
L
M
F
G
S
YLDD
E
K
N
W
G
L
S
F
Y
A
D
K
-
P
E
T
T
K
E
Q
L
---------------
G
E
F
Y
E
--
A
---
L
D
C
L
R
I
-
P
R
----
S
D
-
V
M
Y
T
-
D
W
K
K
D
K
C
E
P
L
E
K
Q
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
53.50
25%
11
- C3 -
3APX
2
A1AG2_HUMAN
A:
[51-179]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
T
P
N
K
T
E
D
T
I
-
F
L
R
E
Y
-
Q
T
R
Q
N
Q
C
F
Y
--
N
S
S
Y
L
N
V
Q
R
E
N
G
T
V
S
---
R
Y
-
E
-
G
G
R
E
--------
H
V
A
H
-------
L
L
F
L
-
R
D
T
K
T
L
M
F
G
S
YLDD
E
K
N
W
G
L
S
F
Y
A
D
K
-
P
E
T
T
K
E
Q
L
---------------
G
E
F
Y
E
--
A
---
L
D
C
L
R
I
-
P
R
----
S
D
-
V
M
Y
T
-
D
W
K
K
D
K
C
E
P
L
E
K
Q
H
E
K
E
R
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
52.96
25%
21
- C3 -
3APU
1
A1AG2_HUMAN
A:
[51-176]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
T
P
N
K
T
E
D
T
I
-
F
L
R
E
Y
-
Q
T
R
Q
N
Q
C
F
Y
--
N
S
S
Y
L
N
V
Q
R
E
N
G
T
V
S
---
R
Y
-
E
-
G
G
R
E
--------
H
V
A
H
-------
L
L
F
L
-
R
D
T
K
T
L
M
F
G
S
YLDD
E
K
N
W
G
L
S
F
Y
A
D
K
-
P
E
T
T
K
E
Q
L
---------------
G
E
F
Y
E
--
A
---
L
D
C
L
R
I
-
P
R
----
S
D
-
V
M
Y
T
-
D
W
K
K
D
K
C
E
P
L
E
K
Q
H
E
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
50.05
13%
4
- C2 -
5AFR
-
?
A:
[8-410]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
N
E
L
I
E
F
V
A
A
T
V
T
G
I
K
N
S
P
K
E
N
E
Q
A
F
I
D
Y
L
H
C
Q
---
Y
L
E
R
F
Q
F
F
L
G
L
F
V
F
L
F
I
V
T
-
I
D
I
A
I
Y
D
A
N
L
A
N
S
T
L
L
I
I
K
Q
I
S
A
I
Y
N
A
G
N
L
A
--
S
I
I
---
T
H
G
V
S
S
V
F
G
---
Q
L
I
K
-
S
D
I
D
K
----
T
R
R
K
L
D
D
-------
I
S
K
Q
-
F
Q
Q
L
H
T
S
I
E
-----
T
P
D
------
L
L
A
M
V
P
S
I
I
K
L
A
---------------
V
S
K
G
A
--
T
---
S
H
D
Y
A
N
-
Y
L
----
P
S
N
D
L
E
S
M
R
F
L
N
I
L
Q
S
I
A
N
K
W
F
L
V
L
K
Q
T
L
F
-
L
D
E
V
E
F
W
S
N
F
Y
E
-----------
V
L
K
S
L
I
E
Q
T
Q
S
Q
E
F
Q
V
C
L
S
V
L
T
---
N
A
K
R
F
HN
L
T
N
L
L
N
E
G
S
L
---
S
D
K
F
K
L
A
D
K
Y
N
Q
F
----
L
S
S
I
P
------
I
D
E
--
D
L
Q
E
L
F
---
P
V
L
A
S
S
L
K
K
F
R
Y
S
G
Y
P
V
Q
R
F
V
V
L
M
D
K
I
S
Q
E
V
M
D
A
I
L
--
S
-
N
L
S
Y
----------
G
S
F
L
G
L
Y
E
K
S
A
----
G
M
I
E
E
W
D
D
I
------------
V
--
Q
D
V
N
L
L
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
46.65
25%
87
- C3 -
3KQ0
1
A1AG1_HUMAN
A:
[52-175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
T
P
N
K
T
E
D
T
I
-
F
L
R
E
Y
-
Q
T
R
Q
D
Q
C
I
Y
--
N
T
T
Y
L
N
V
Q
R
E
N
G
T
I
S
---
R
--
Y
V
G
G
Q
E
--------
H
F
A
H
-------
L
L
I
L
-
R
D
T
K
T
Y
M
L
A
FDVND
E
K
N
W
G
L
S
V
Y
A
D
K
-
P
E
T
T
K
E
Q
L
---------------
G
E
F
Y
E
--
A
---
L
D
C
L
R
I
-
P
K
----
S
D
-
V
V
Y
T
-
D
W
K
K
D
K
C
E
P
L
E
K
Q
H
E
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
35.64
30%
56
- C3 -
4RBN
-
?
A:
[432-503]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
H
S
D
I
Y
W
-
Q
E
N
-
E
D
K
Y
H
F
S
C
Q
Y
T
A
D
L
L
A
M
N
S
A
D
F
-------
I
V
--
T
S
T
---
Y
Q
E
I
A
G
T
R
E
---
A
--
E
-
G
Q
Y
E
S
Y
QAF
S
M
P
D
L
Y
R
-------
V
I
H
G
-
I
D
L
F
D
P
K
F
N
-----
I
V
S
------
P
G
A
-
N
A
D
I
Y
F
P
Y
---------------
S
D
P
N
R
--
R
---
L
H
S
L
I
P
-
E
I
----
E
S
L
I
F
D
D
-
A
T
N
L
P
A
R
G
Y
L
Q
D
P
D
K
P
L
I
F
T
M
A
R
L
D
R
I
K
N
I
T
G
L
V
E
-----------
L
Y
A
A
S
P
R
L
R
S
L
A
N
L
V
I
V
G
G
K
I
D
---
P
Q
H
S
S
--
D
H
E
E
Q
E
Q
I
H
R
---
M
H
Q
L
M
D
E
H
E
L
D
Q
Q
----
V
R
W
L
G
------
M
R
L
--
D
K
N
L
A
G
---
E
L
Y
R
Y
I
A
D
K
R
G
I
F
V
Q
P
A
L
F
E
A
F
G
-
L
T
I
I
E
A
M
-
A
S
G
L
--
P
T
F
A
T
R
----------
Y
G
G
P
L
E
I
I
Q
N
N
R
---
S
-
G
F
H
I
D
P
N
------------
Q
--
G
A
A
T
A
D
L
I
A
D
F
F
E
K
N
L
E
N
P
Q
E
W
E
R
I
S
Q
G
A
L
D
------
R
V
A
S
R
Y
T
W
K
L
Y
A
E
R
M
M
T
L
S
R
I
Y
G
F
W
K
F
V
S
G
L
E
R
E
E
T
D
R
Y
L
N
M
F
Y
H
L
Q
F
R
P
L
A
N
-
R
L
A
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
34.30
32%
153
* C3 *
2VM6
1
B2LA1_HUMAN
A:
[61-113]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
V
S
V
D
T
A
R
T
L
F
N
Q
-----------
V
M
E
K
E
F
E
D
G
I
I
N
W
G
-------
R
---
I
V
T
I
F
--
A
F
E
G
I
-
L
I
K
K
---
L
L
R
Q
Q
I
A
P
D
V
D
T
Y
----
K
E
I
S
Y
------
F
V
A
--
E
F
I
M
N
N
---
T
G
E
W
I
R
Q
N
G
G
W
E
N
G
F
V
K
K
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
32.12
32%
146
- C3 -
3MQP
1
B2LA1_HUMAN
A:
[70-122]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
V
S
V
D
T
A
R
T
L
F
N
Q
-----------
V
M
E
K
E
F
E
D
G
I
I
N
W
G
-------
R
---
I
V
T
I
F
--
A
F
E
G
I
-
L
I
K
K
---
L
L
R
Q
Q
I
A
P
D
V
D
T
Y
----
K
E
I
S
Y
------
F
V
A
--
E
F
I
M
N
N
---
T
G
E
W
I
R
Q
N
G
G
W
E
N
G
F
V
K
K
F
E
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
31.38
19%
233
- C3 -
3J04
-
MLRM_CHICK
B:
[99-132]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
I
R
N
A
---------------
F
A
C
F
D
EE
A
---
S
G
F
I
-
H
E
D
H
----
L
R
E
L
L
T
T
-
M
G
D
R
F
T
D
E
E
V
D
E
M
Y
R
E
A
P
I
D
K
K
G
N
F
N
Y
V
E
F
T
R
I
L
K
-----------
H
G
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
31.21
32%
172
- C3 -
3I1H
1
B2LA1_HUMAN
A:
[72-122]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
V
S
V
D
T
A
R
T
L
F
N
Q
-----------
V
M
E
K
E
F
E
D
G
I
I
N
W
G
-------
R
---
I
V
T
I
F
--
A
F
E
G
I
-
L
I
K
K
---
L
L
R
Q
Q
I
A
P
D
V
D
T
Y
----
K
E
I
S
Y
------
F
V
A
--
E
F
I
M
N
N
---
T
G
E
W
I
R
Q
N
G
G
W
E
N
G
F
V
K
K
F
E
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
30.63
7%
230
- C3 -
1UHK
1
AEQ2_AEQVI
A:
[110-140]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
D
A
L
---------------
F
D
I
V
D
KD
Q
---
N
G
A
I
-
T
L
D
E
----
W
K
A
Y
T
K
A
-
A
G
I
I
Q
S
S
E
D
C
E
E
T
F
R
V
C
D
I
D
E
S
G
Q
L
D
V
D
E
M
T
R
Q
H
L
-----------
G
F
W
Y
T
M
D
P
A
C
E
K
L
Y
G
G
A
V
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
30.48
32%
148
- C3 -
4ZEQ
-
B2LA1_HUMAN
A:
[70-122]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
V
S
V
D
T
A
R
T
L
F
N
Q
-----------
V
M
E
K
E
F
E
D
G
I
I
N
W
G
-------
R
---
I
V
T
I
F
--
A
F
E
G
I
-
L
I
K
K
---
L
L
R
Q
Q
I
A
P
D
V
D
T
Y
----
K
E
I
S
Y
------
F
V
A
--
E
F
I
M
N
N
---
T
G
E
W
I
R
Q
N
G
G
W
E
N
G
F
V
K
K
F
E
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
28.22
32%
121
- C3 -
2UVP
-
?
A:
[38-78]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
A
K
L
I
A
-------
Q
T
I
S
-
H
V
L
N
G
G
S
L
L
-----
V
S
A
------
D
S
S
-
R
H
W
F
L
N
Y
I
---------------
L
S
N
L
N
--
P
---
K
D
L
K
E
R
-
P
L
----
L
S
V
I
D
F
N
-
A
S
S
F
Y
P
K
N
D
A
N
L
S
L
A
T
I
E
M
T
Y
Q
N
P
M
F
W
H
V
G
K
I
E
N
E
-----------
G
L
K
T
I
L
L
S
K
I
P
S
F
L
W
L
F
E
E
L
K
E
---
D
C
L
L
L
--
K
E
H
D
S
L
L
D
Y
K
---
L
L
Q
L
F
K
L
F
E
N
A
L
F
----
S
V
L
Y
N
------
K
V
T
--
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
27.03
13%
174
- C3 -
3KEV
-
?
A:
[8-40]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
L
E
L
---------------
F
Q
T
Y
K
--
E
PL-
G
N
Y
I
-
G
A
E
G
----
L
Q
R
L
F
E
D
-
I
Q
V
D
P
S
D
V
V
T
L
V
L
A
W
K
L
K
A
S
S
T
C
E
F
S
E
K
E
F
V
E
G
L
A
-----------
N
L
Q
V
D
S
L
E
K
L
K
R
K
L
S
S
L
R
K
E
I
E
---
D
P
S
K
F
--
R
A
F
Y
Q
F
V
F
Q
Y
---
S
K
E
P
S
Q
R
S
L
P
A
E
T
----
A
M
A
L
W
------
D
V
L
--
L
R
G
R
F
S
---
L
L
D
S
W
L
E
F
L
K
N
N
T
H
S
I
S
R
D
T
W
N
L
-
L
Y
D
F
S
Q
L
-
K
D
L
S
--
D
Y
D
A
W
P
----------
V
L
I
D
D
F
V
K
W
L
K
H
---
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
24.55
14%
196
- C3 -
3TDU
1
CUL1_HUMAN (first)
A:
[6-38]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
Q
L
---------------
Y
N
R
Y
K
--
D
PQD
E
N
K
I
-
G
I
D
G
----
I
Q
Q
F
C
D
D
-
L
A
L
D
P
A
S
I
S
V
L
I
I
A
W
K
F
R
A
A
T
Q
C
E
F
S
K
Q
E
F
M
D
G
M
T
-----------
E
L
G
C
D
S
I
E
K
L
K
A
Q
I
P
K
M
E
Q
E
L
K
---
E
P
G
R
F
--
K
D
F
Y
Q
F
T
F
N
F
---
A
K
N
P
G
Q
K
G
L
D
L
E
M
----
A
I
A
Y
W
------
N
L
V
--
L
N
G
R
F
K
---
F
L
D
L
W
N
K
F
L
L
E
H
H
K
R
S
I
P
K
D
T
W
N
-
L
L
L
D
F
S
T
-
M
I
A
D
--
D
M
S
N
Y
D
----------
E
E
G
A
W
P
V
L
I
D
D
F
---
V
-
E
F
A
R
P
Q
I
------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------