@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UCP1_HUMAN: (2015-12-12 )
MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQTMDCAT
Atome Classification :
(20 SA)
----------------------.........10..--......---20--......----.----.30...----.....40.......----.-50---.-..------...--------...-------60.......--.70..-......-80-------.....--------.-..90...-...---..100----...-..------..----------.--110......----...---120----....-..-----------.-----..-----------------130-.-......---..140-..--......150...---....160.....-..170.----..-...-----.-180..------.....190......----.200-.........210-------.....-..220...---..-.----.230.----.-------.......240----..---..-----..-----..250..-....---.-.-------------------------260.......270......----------.280-......---.-------..290...----------....300.....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------MGGLTASDVHP
T
L
--
G
V
Q
L
F
S
---
A
G
--
I
A
A
C
L
A
----
D
----
V
I
TFPL----D
T
A
K
V
R
L
Q
V
QGECP----T-S----S-
V
I
------
R
YK--------G
V
L
-------
G
T
I
T
A
V
VKT--EG
R
M
K
-LYSGL
P
-
A
G
-------
L
Q
R
Q
I
--------S-SA
S
L
R
I
G-
L
Y
D
---
T
V
Q
E
-----
F
L
T-AG------KE----------T--
A
--
P
S
L
G
S
K
----
I
L
A
---
G
------LTTG-
G
V
-----------
A
-----
V
F
-----------------I---G-QP
T
E
V
V
---
K
V
R
L
--
Q
A
--
Q
SHLHGIKPRYT---GTY
N
A
Y
R
I
I
A
TT-EGLTGL----WK-GT
T
-----
P
-
N
L
M
R
S
------
V
I
I
N
C
T
E
L
V
T
Y
D
L
M
----
K
E
---
A
F
VKNNILADDV-------
P
C
H
L
V
-
S
A
L
I
A
G
F
C
---
A
T
-A----MS--S----
P
-------
V
D
V
V
K
T
RFI-----NS---PP-----GQ-----YKSV-PN-C
A
M
K
---
V
-F-------------------------TNEG
P
T
A
F
F
K
G
L
V
P
S
F
L
R
L----------GS---W
N
V
I
M
F
---
V
-------
C
F
E
Q
L
K
R
E
----------
L
S
KSRQTMDCAT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.30
57%
-63
- C7 -
2LCK
-
UCP2_MOUSE
A:
[15-307]
--------------------------------------
V
K
F
L
G
---
A
G
--
T
A
A
C
I
A
----
D
----
L
I
T
F
P
L
----
D
T
A
K
V
R
L
Q
I
Q
G
E
S
Q
G
L
V
R
T
-
A
----
A
-
S
A
------
Q
Y
R
--------
G
V
L
-------
G
T
I
L
T
M
V
R
T
--
E
G
P
R
S
-
L
Y
N
G
L
V
-
A
G
-------
L
Q
R
Q
M
--------
S
-
F
A
S
V
R
I
G
-
L
Y
D
---
S
V
K
Q
-----
F
Y
T
-
K
G
------
S
E
----------
H
--
A
---
G
I
G
S
R
----
L
L
A
---
G
------
S
T
T
G
-
A
L
-----------
A
-----
V
A
-----------------
V
---
A
-
Q
P
T
D
V
V
---
K
V
R
F
--
Q
A
--
Q
A
R
A
G
G
G
R
-
R
Y
Q
---
S
T
V
E
A
Y
K
T
I
A
R
E
-
E
G
I
R
G
L
----
W
K
-
G
T
S
-----
P
-
N
V
A
R
N
------
A
I
V
N
C
A
E
L
V
T
Y
D
L
I
----
K
D
---
T
L
L
K
A
N
L
M
T
D
D
L
-------
P
C
H
F
T
-
S
A
F
G
A
G
F
C
---
T
T
-
V
----
I
A
--
S
----
P
-------
V
D
V
V
K
T
R
Y
M
-----
N
S
---
A
L
-----
G
Q
-----
Y
H
S
A
-
G
H
-
C
A
L
T
---
M
-
L
-------------------------
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
----------
G
S
---
W
N
V
V
M
F
---
V
-------
T
Y
E
Q
L
K
R
A
----------
L
M
A
A
Y
Q
S
R
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
76.27
58%
-60
- C7 -
2LCK
-
UCP2_MOUSE
A:
[14-306]
-------------------------------------
T
V
K
F
L
G
---
A
G
--
T
A
A
C
I
A
----
D
----
L
I
T
F
P
L
----
D
T
A
K
V
R
L
Q
I
Q
G
E
S
Q
----
G
-
L
V
R
T
A
A
-
S
A
------
Q
Y
R
--------
G
V
L
-------
G
T
I
L
T
M
V
R
T
--
E
G
P
R
S
-
L
Y
N
G
L
V
-
A
G
-------
L
Q
R
Q
M
--------
S
-
F
A
S
V
R
I
G
-
L
Y
D
---
S
V
K
Q
-----
F
Y
T
-
K
G
------
S
-----------
E
--
H
--
A
G
I
G
S
R
----
L
L
A
---
G
------
S
T
T
G
-
A
L
-----------
A
-----
V
A
-----------------
V
---
A
-
Q
P
T
D
V
V
---
K
V
R
F
--
Q
A
--
Q
A
R
A
G
-
G
G
R
R
Y
Q
---
S
T
V
E
A
Y
K
T
I
A
R
E
-
E
G
I
R
G
L
----
W
K
-
G
T
S
-----
P
-
N
V
A
R
N
------
A
I
V
N
C
A
E
L
V
T
Y
D
L
I
----
K
D
---
T
L
L
K
A
N
L
M
T
D
D
L
-------
P
C
H
F
T
-
S
A
F
G
A
G
F
C
---
T
T
-
V
----
I
A
--
S
----
P
-------
V
D
V
V
K
T
R
Y
M
-----
N
S
---
A
L
-----
G
Q
-----
Y
H
S
A
-
G
H
-
C
A
L
T
---
M
-
L
-------------------------
R
K
E
G
P
R
A
F
Y
K
G
F
M
P
S
F
L
R
L
----------
G
S
---
W
N
V
V
M
F
---
V
-------
T
Y
E
Q
L
K
R
A
----------
L
M
A
A
Y
Q
S
R
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
74.97
22%
-46
- C7 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------------------
D
Q
A
L
S
F
--
L
K
D
F
L
A
---
G
G
--
V
A
A
A
I
S
----
K
----
T
A
V
A
P
I
----
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
----
Q
-
I
S---
A
-
E
K
------
Q
Y
K
--------
G
I
I
-------
D
C
V
V
R
I
P
K
E
--
Q
G
F
L
S
-
F
W
R
G
N
L
-
A
N
-------
V
I
R
Y
F
--------
P
-
T
Q
A
L
N
F
A
-
F
K
D
---
K
Y
K
Q
-----
I
F
L
-
G
G
------
V
D
RHKQ------
F
--
W
--
R
Y
F
A
G
N
----
L
A
S
---
G
------
G
A
A
G
-
A
T
-----------
S
-----
L
C
-----------------
F
---
V
-
Y
P
L
D
F
A
---
R
T
R
L
--
A
A
--
D
V
G
K
G
A
A
Q
R
E
F
T
---
G
L
G
N
C
I
T
K
I
F
K
S
-
D
G
L
R
G
L
----
Y
Q
-
G
F
N
-----
V
-
S
V
Q
G
I
------
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
----
K
G
---
M
L
P
D
P
K
--
N
V
H
I
-------
I
V
S
W
M
-
I
A
Q
T
V
T
A
V
---
A
G
-
L
----
V
S
--
Y
----
P
-------
F
D
T
V
R
R
R
M
M
-----
M
Q
---
S
G
RKGAD
I
M
-----
Y
T
G
T
-
V
D
-
C
W
R
K
---
I
-
A
-------------------------
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
----------
M
G
----
G
A
F
V
L
---
V
-------
L
Y
D
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.06
23%
-48
- C7 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------------------
D
Q
A
L
S
F
--
L
K
D
F
L
A
---
G
G
--
V
A
A
A
I
S
----
K
----
T
A
V
A
P
I
----
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
----
Q
I
S
----
A
-
E
K
------
Q
Y
K
--------
G
I
I
-------
D
C
V
V
R
I
P
K
E
--
Q
G
F
L
S
-
F
W
R
G
N
L
-
A
N
-------
V
I
R
Y
F
--------
P
-
T
Q
A
L
N
F
A
-
F
K
D
---
K
Y
K
Q
-----
I
F
L
-
G
G
------
V
D
----------
R
--
H
--
K
Q
F
W
R
Y
----
F
A
G
---
N
------
L
A
S
G
-
G
A
-----------
A
G
A
T
S
L
C
F
-----------------
V
-----
Y
P
L
D
F
A
---
R
T
R
L
--
A
A
--
D
V
G
K
G
A
A
Q
R
E
F
T
---
G
L
G
N
C
I
T
K
I
F
K
S
-
D
G
L
R
G
L
----
Y
Q
-
G
F
N
-----
V
-
S
V
Q
G
I
------
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
----
K
---------
G
M
L
P
D
P
K
-------
N
V
H
I
I
-
V
S
W
M
I
A
Q
T
---
V
T
-
A
V
A
G
L
V
S
--
Y
----
P
-------
F
D
T
V
R
R
R
M
M
-----
M
Q
---
S
G
-----
R
K
GADIM
Y
T
G
T
-
V
D
-
C
W
R
K
---
I
-
A
-------------------------
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
-----------
G
M
---
G
G
A
F
V
L
---
V
-------
L
Y
D
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
72.10
22%
-52
- C7 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------------------
D
Q
A
L
S
F
--
L
K
D
F
L
A
---
G
G
--
V
A
A
A
I
S
----
K
----
T
A
V
A
P
I
----
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
----
Q
I
S
----
A
-
E
K
------
Q
Y
K
--------
G
I
I
-------
D
C
V
V
R
I
P
K
E
--
Q
G
F
L
S
-
F
W
R
G
N
L
-
A
N
-------
V
I
R
Y
F
--------
P
-
T
Q
A
L
N
F
A
-
F
K
D
---
K
Y
K
Q
-----
I
F
L
-
G
G
VDRH--
K
Q
----------
F
--
W
--
R
Y
F
A
G
N
----
L
A
S
---
G
------
G
A
A
G
-
A
T
-----------
S
-----
L
C
-----------------
F
---
V
-
Y
P
L
D
F
A
---
R
T
R
L
--
A
A
--
D
V
G
K
G
A
A
Q
R
E
F
T
---
G
L
G
N
C
I
T
K
I
F
K
S
-
D
G
L
R
G
L
----
Y
Q
-
G
F
N
-----
V
-
S
V
Q
G
I
------
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
----
K
G
---
M
L
P
D
P
K
--
N
V
H
I
-------
I
V
S
W
M
-
I
A
Q
T
V
T
A
V
---
A
G
-
L
----
V
S
--
Y
----
P
-------
F
D
T
V
R
R
R
M
M
M
Q
SGR
K
G
---
A
D
-----
I
M
-----
Y
T
G
T
-
V
D
-
C
W
R
K
---
I
-
A
-------------------------
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
G
----------
M
G
---
G
A
F
V
L
V
---
L
-------
Y
D
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
71.56
21%
-62
- C6 -
1ZEL
10
?
A:
[2-297]
------------------------
A
M
V
V
S
P
A
G
A
D
R
--
R
I
P
T
W
A
---
S
R
--
V
V
S
G
L
A
----
R
D
RPV
V
V
T
K
E
D
----
L
T
Q
R
L
T
E
A
G
C
G
R
D
P
----
D
-
S
----
A
-
I
R
------
E
L
R
R
I
GW
L
V
Q
L
P
V
K
-------
G
T
W
A
F
I
P
P
G
--
E
A
A
I
S
D
P
Y
L
P
L
R
-
S
W
-------
L
A
R
D
Q
NAGFMLAG
A
-
S
A
A
W
H
L
G
-
Y
L
D
---
R
Q
P
D
G
R
I
P
I
W
L
P
-
P
A
------
K
R
----------
L
--
P
--
D
G
L
A
S
Y
----
V
S
V
V
R
I
P
------
W
N
A
A
-
D
T
-----------
A
-----
L
L
-----------------
A
---
P
-
R
P
A
L
L
V
---
R
R
R
L
--
D
L
--
V
A
W
A
T
G
L
P
A
--
L
---
G
P
E
A
L
L
V
Q
I
A
T
R
-
P
A
S
F
G
P
----
W
A
-
D
L
V
-----
P
-
H
L
-
D
D
------
L
V
A
D
C
S
D
E
R
L
E
R
L
L
SGRP
T
S
---
A
W
Q
R
A
S
Y
L
L
D
S
G
-------
G
---
E
-
P
A
R
G
Q
A
L
L
---
A
K
-
R
----
H
T
--
E
----
V
-------
M
P
V
--
T
R
F
T
-----
T
A
---
H
S
-----
G
E
-----
S
V
W
A
-
P
E
-
Y
Q
L
V
---
D
-
E
-------------------------
L
---------------------------------------------------
V
V
P
L
L
R
V
----------
I
G
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
67.59
23%
-48
- C7 -
2C3E
4
ADT1_BOVIN
A:
[1-293]
----------------------------
S
D
Q
A
L
S
F
--
L
K
D
F
L
A
---
G
G
--
V
A
A
A
I
S
----
K
----
T
A
V
A
P
I
----
E
R
V
K
L
L
L
Q
V
Q
H
A
S
K
----
Q
I
S
----
A
-
E
K
------
Q
Y
K
--------
G
I
I
-------
D
C
V
V
R
I
P
K
E
--
Q
G
F
L
S
-
F
W
R
G
N
L
-
A
N
-------
V
I
R
Y
F
--------
P
-
T
Q
A
L
N
F
A
-
F
K
D
---
K
Y
K
Q
-----
I
F
L
-
G
G
------
V
D
----------
R
--
H
--
K
Q
F
W
R
Y
----
F
A
G
---
N
------
L
A
S
G
-
G
A
-----------
A
G
A
T
S
L
C
F
-----------------
V
-----
Y
P
L
D
F
A
---
R
T
R
L
--
A
A
--
D
V
G
K
G
A
A
Q
R
E
F
T
---
G
L
G
N
C
I
T
K
I
F
K
S
-
D
G
L
R
G
L
----
Y
Q
-
G
F
N
-----
V
-
S
V
Q
G
I
------
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
----
K
---------
G
M
L
P
D
P
K
-------
N
V
H
I
I
-
V
S
W
M
I
A
Q
T
---
V
T
-
A
V
A
G
L
V
S
--
Y
----
P
-------
F
D
T
V
R
R
R
M
M
-----
M
Q
---
S
G
-----
R
K
GADIM
Y
T
G
T
-
V
D
-
C
W
R
K
---
I
-
A
-------------------------
K
D
E
G
P
K
A
F
F
K
G
A
W
S
N
V
L
R
-----------
G
M
---
G
G
A
F
V
L
---
V
-------
L
Y
D
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
65.64
16%
-80
* C6 *
4UVJ
-
SCC3_YEAST
A:
[2-387]
-------------------------
D
S
V
K
E
I
V
L
P
L
--
F
Y
D
L
L
N
---
A
A
SI
L
C
P
L
L
E
----
S
----
F
I
T
F
S
E
----
T
E
L
K
K
I
T
D
K
T
I
K
A
F
----
M
-
D
----
S
-
T
I
G
NSKVD
M
K
Y
--------
D
I
F
-------
A
K
F
I
H
H
I
H
H
--
F
E
K
-----
K
E
L
Q
-
E
K
-------
F
L
N
Q
I
-----------
A
T
L
K
I
H
-
L
K
K
---
F
L
Q
E
-----
K
M
D
-
P
N
NSRDD
Y
K
D
----------
L
--
T
--
C
S
L
Y
E
L
----
Y
I
N
---
K
------
L
T
I
L
-
G
R
D
Y
P
I
E
V
D
E
E
L
L
Q
-----
L
F
-----------------
L
---
N
-
N
F
V
S
R
I
---
P
I
M
F
--
Q
D
FD
D
S
T
A
Q
E
I
N
F
K
M
L
---
V
L
L
A
T
W
N
L
E
K
W
R
-
E
I
I
E
K
V
----
R
D
-
L
R
S
-----
V
W
K
P
I
A
A
------
I
I
G
R
L
N
T
L
V
I
S
L
A
A
----
T
N
E
T
F
E
N
I
N
S
L
F
Y
L
K
W
S
-------
A
C
T
S
L
-
M
D
I
I
V
A
I
K
---
I
F
-
E
----
L
K
--
L
----
P
-------
A
D
A
T
T
W
R
Y
S
-----
M
S
E
Q
F
P
F
-----
Y
L
-----
H
D
N
A
-
S
K
-
V
L
L
K
---
I
-
F
L
Y
L
E
S
L
F
A
K
Q
V
D
V
Q
L
E
R
V
ADEDANL
N
D
L
P
E
T
G
F
F
E
N
I
E
T
E
F
L
L
F
----------
T
V
---
K
L
K
G
L
M
K
L
N
I
-------
L
D
E
R
F
A
S
R
----------
V
A
L
N
K
E
K
L
G
P
L
F
K
K
I
V------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
64.93
18%
-76
- C6 -
3W3W
1
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
E
E
W
--
I
T
E
N
N
I
---
E
Y
--
L
L
T
F
L
A
----
E
----
Q
A
A
F
S
Q
----
D
--------
T
T
V
A
A
----
L
-
S
----
A
-
V
L
------
F
R
K
--------
L
A
L
-------
K
A
P
I
T
H
I
R
K
--
E
V
L
A
Q
-
I
R
S
S
L
L
-
K
G
-------
F
L
S
E
---------
R
-
A
D
S
I
R
H
K
-
L
S
D
---
A
I
A
E
-----
C
V
Q
-
D
D
------
L
P
----------
A
--
W
--
P
E
L
L
Q
A
----
L
I
E
---
S
------
L
K
S
G
-----------------------------------------------------------------------
N
P
N
F
R
---
E
S
--
S
F
R
I
L
T
T
V
----------------------
P
-
Y
L
I
T
A
------
V
----
D
I
N
S
I
L
P
I
F
----
Q
S
---
G
F
T
D
A
S
---
D
N
V
-------
K
I
A
A
V
-
T
A
F
V
G
Y
F
K
---
Q
L
-
P
----
K
S
EW
S
----
K
-------
L
G
I
L
L
P
S
L
L
-----
N
S
---------------------------
L
P
---
R
-
F
-------------------------
L
D
D
G
K
D
D
A
L
A
S
V
F
E
S
L
I
E
L
----------
V
E
---
L
A
P
K
L
F
---
K
---------
D
M
F
D
Q
I
----------
I
Q
F
T
D
M
V
I
K
N
K
D
LEP
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
EVSIDDDDA
A
E
W
I
E
SDDTDDEEE
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
LGGEYL
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
STE
W
R
E
R
F
A
A
M
M
A
L
S
S
A
AEGCA
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
NDPH
P
R
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
S
P
F
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
L
TSECT
S
R
V
Q
T
H
A
A
A
A
L
V
N
F
S
E
FASKDILEPY
L
D
S
L
L
T
N
L
L
V
L
L
Q
SNK
L
Y
V
Q
E
Q
A
L
T
T
I
A
F
I
A
E
A
A
KNKFIKYYDTL
M
P
L
L
L
N
V
L
K
VN
S
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
A
V
G
K
E
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
SD
A
L
R
S
Y
L
E
Q
S
W
S
R
I
C
R
I
L
GDDFVPLLPIVI
P
P
L
L
I
T
A
K
ATQDVGLIEEEEAANFQQYPD
W
D
V
V
Q
V
QG
K
H
I
A
I
H
T
S
V
L
D
D
K
V
S
A
M
E
L
L
Q
S
Y
A
T
L
L
RGQFAVY
V
K
E
V
M
E
EI
A
L
P
S
L
D
FYLH
D
G
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
AE
E
L
V
L
L
W
H
K
A
S
S
K
L
I
G
G
L
M
S
EPM
P
E
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
GDNCLS
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
DRDEYNED
F
T
D
E
D
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
GHY
L
K
N
L
E
N
I
W
P
M
I
N
T
F
L
LE
P
I
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
YEQTASMKNAF
I
P
K
V
T
E
C
L
ISPD
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
YAPSTYADVCIPT
L
D
T
L
V
Q
I
V
DGSKLEEN
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
NSNIPD
T
Y
T
A
N
W
F
K
T
LPTITD
K
E
A
A
S
F
N
Y
Q
F
L
S
QVCAQSN
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
RSLT
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F
14
HHSearch
62.43
28%
-39
- C7 -
1OKC
9
ADT1_BOVIN
A:
[110-293]
--------------------------------
R
Y
F
--
A
G
N
L
A
S
---
G
G
--
A
A
G
A
T
S
----
L
----
C
F
V
Y
P
L
----
D
F
A
R
T
R
L
A
A
D
V
G
K
G
----
A
------
A
-
Q
R
------
E
F
T
--------
G
L
G
-------
N
C
I
T
K
I
F
K
S
--
D
G
L
R
G
-
L
Y
Q
G
F
N
-
V
S
-------
V
Q
G
I
I
--------
I
-
Y
R
A
A
Y
F
G
-
V
Y
D
---
T
A
K
G
-----
M
L
P
-
D
P
------
K
--------------
N
--
V
H
I
I
V
S
----
W
M
I
---
A
------
Q
T
V
T
-
A
V
-----------
A
-----
G
L
-----------------
V
---
S
-
Y
P
F
D
T
V
---
R
R
R
M
--
M
M
--
Q
S
G
R
K
G
A
D
I
M
Y
T
---
G
T
V
D
C
W
R
K
I
A
K
D
-
E
G
P
K
A
F
----
F
K
-
G
A
W
-----
S
-
N
V
L
R
G
------
M
G
-
G
A
F
V
L
V
L
Y
D
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.02
20%
-50
- C7 -
4C9H
5
ADT2_YEAST
A:
[25-294]
--------------------------------------
I
D
F
L
M
---
G
G
--
V
S
A
A
V
A
----
K
----
T
A
A
S
P
I
----
E
R
V
K
L
L
I
Q
N
Q
D
E
M
L
----
K
-
Q
----
G
-
T
L
DR----
K
Y
A
--------
G
I
L
-------
D
C
F
K
R
T
A
T
Q
--
E
G
V
I
S
-
F
W
R
G
N
T
-
A
N
-------
V
I
R
Y
F
--------
P
-
T
Q
A
L
N
F
A
-
F
K
D
---
K
I
K
A
-----
M
F
G
-
F
K
------
K
E
----------
E
G
Y
A
--
K
W
F
A
G
N
----
L
A
S
---
G
------
G
A
A
G
-
A
L
-----------
S
-----
L
L
-----------------
F
---
V
-
Y
S
L
D
Y
A
---
R
T
R
L
--
A
A
DS-------
A
R
Q
F
N
---
G
L
I
D
V
Y
K
K
T
L
K
S
-
D
G
V
A
G
L
----
Y
R
-
G
F
L
-----
P
-
S
V
V
G
I
------
V
V
Y
R
G
L
Y
F
G
M
Y
D
S
L
----
K
---------------
L
-------
A
S
F
L
L
-
G
W
V
V
T
T
-
G
---
A
S
-
T
----
C
S
--
Y
----
P
-------
L
D
T
V
R
R
R
M
M
M
T
---
S
G
---
Q
A
-----
V
K
-----
Y
D
G
A
-
F
D
-
C
L
R
K
---
I
-
V
-------------------------
A
A
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
G
----------
V
A
---
G
A
G
V
I
S
---
M
-------
Y
D
Q
L
Q
M
I
L
----------
F
G
K
K
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
56.58
20%
-40
- C7 -
4C9J
4
ADT3_YEAST
A:
[25-298]
--------------------------------
T
N
F
--
A
I
N
F
L
M
---
G
G
--
V
S
A
A
I
A
----
K
----
T
A
A
S
P
I
----
E
R
V
K
I
L
I
Q
N
Q
D
E
M
I
----
K
-
Q
----
G
-
T
L
DK----
K
Y
S
--------
G
I
V
-------
D
C
F
K
R
T
A
K
Q
--
E
G
L
I
S
-
F
W
R
G
N
T
-
A
N
-------
V
I
R
Y
F
--------
P
-
T
Q
A
L
N
F
A
-
F
K
D
---
K
I
K
-------
L
M
-
F
G
------
F
K
----------
K
--
E
--
E
G
Y
G
K
W
----
F
A
G
---
N
------
L
A
S
G
-
G
A
-----------
A
G
A
L
S
L
L
F
-----------------
V
-----
Y
S
L
D
F
A
---
R
T
R
L
A
A
D
A
--
K
S
-----
A
R
Q
F
N
---
G
L
T
D
V
Y
K
K
T
L
K
S
-
D
G
I
A
G
L
----
Y
R
-
G
F
M
-----
P
-
S
V
V
G
I
------
V
V
Y
R
G
L
Y
F
G
M
F
D
S
L
----
K
-------------------------------
F
L
L
G
W
V
---
V
T
-
T
----
G
A
--
S
T
C
S
Y
P
-------
L
D
T
V
R
R
R
M
M
M
T
---
S
G
---
Q
A
-----
V
K
-----
Y
N
G
A
-
I
D
-
C
L
K
K
---
I
-
V
-------------------------
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
----------
V
A
---
G
A
G
V
I
S
---
M
-------
Y
D
Q
L
Q
M
I
L
----------
F
G
K
K
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.08
20%
-39
- C7 -
4C9Q
5
ADT3_YEAST
A:
[20-298]
---------------------------
A
K
Q
Q
E
T
N
F
--
A
I
N
F
L
M
---
G
G
--
V
S
A
A
I
A
----
K
----
T
A
A
S
P
I
----
E
R
V
K
I
L
I
Q
N
Q
D
E
M
I
----
K
-
Q
----
G
-
T
L
DK----
K
Y
S
--------
G
I
V
-------
D
C
F
K
R
T
A
K
Q
--
E
G
L
I
S
-
F
W
R
G
N
T
-
A
N
-------
V
I
R
Y
F
--------
P
-
T
Q
A
L
N
F
A
-
F
K
D
---
K
I
K
-------
L
M
-
F
G
------
F
K
----------
K
--
E
---
G
Y
G
K
W
----
F
A
G
---
N
------
L
A
S
G
-
G
A
-----------
A
G
A
L
S
L
L
F
-----------------
V
-----
Y
S
L
D
F
A
---
R
T
R
L
A
A
D
A
--
K
S
-----
A
R
Q
F
N
---
G
L
T
D
V
Y
K
K
T
L
K
S
-
D
G
I
A
G
L
----
Y
R
-
G
F
M
-----
P
-
S
V
V
G
I
------
V
V
Y
R
G
L
Y
F
G
M
F
D
S
L
----
K
P
---
L
---------------------
F
L
-
A
S
F
L
L
G
W
V
---
V
T
-
T
----
G
A
--
S
T
C
S
Y
P
-------
L
D
T
V
R
R
R
M
M
M
T
---
S
G
---
Q
A
-----
V
K
-----
Y
N
G
A
-
I
D
-
C
L
K
K
---
I
-
V
-------------------------
A
S
E
G
V
G
S
L
F
K
G
C
G
A
N
I
L
R
S
----------
V
A
---
G
A
G
V
I
S
---
M
-------
Y
D
Q
L
Q
M
I
L
----------
F
G
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
53.95
14%
-55
- C3 -
3VS8
-
?
A:
[7-410]
----------HPN
S
A
V
L
A
D
F
I
P
V
Q
L
A
K
P
V
P
Q
R
I
T
L
--
E
L
T
A
Y
G
---
F
A
--
R
A
H
C
L
S
N
GIT
D
----
E
E
G
F
V
Q
----
V
Y
K
T
V
K
E
K
F
D
K
Y
A
V
----
S
-
P
----
A
-
Q
I
------
K
Q
R
--------
Q
L
V
YF-----
P
K
L
T
D
I
R
F
G
--
D
G
N
F
D
-
I
A
D
P
E
P
-
D
Q
-------
A
H
L
R
L
--------
F
-
D
I
K
K
D
P
R
-
G
A
D
---
L
K
T
R
-----
H
E
S
-
Y
A
------
K
V
----------
V
--
G
--
K
G
L
E
Q
M
----
F
E
G
---
T
------
L
E
A
P
-
D
D
-----------
L
-----
I
H
-----------------
V
T
CS
G
-
Y
L
A
P
S
P
---
A
E
R
M
--
V
A
--
D
R
G
W
F
E
T
T
V
T
H
S
YNM
G
C
Y
G
A
F
P
A
I
K
M
A
-
H
G
M
L
A
S
----
A
Q
W
G
A
T
-----
P
-
P
K
T
R
-------
V
D
I
A
H
T
E
L
M
S
A
H
N
N
----
I
A
---
E
S
R
V
D
N
I
I
S
A
T
L
-------
F
S
D
G
L
-
I
K
Y
S
V
Y
P
E
---
D
E
-
L
----
R
R
--
Q
----
G
L
R
G
L
R
I
-
L
A
M
S
E
H
L
L
P
-----
D
S
---
A
D
-----
T
M
-----
T
G
V
P
-
G
S
-
H
Q
F
V
---
M
-
T
-------------------------
L
S
P
L
V
P
A
I
I
K
R
H
V
R
A
F
A
V
D
L
L
R
R
A
GMDFE
R
D
---
K
D
A
L
S
F
---
A
IHPGGPK
I
V
D
H
V
Q
E
E
----------
L
G
L
A
E
D
Q
V
A
I
S
K
S
V
F
L
E
NGNMSSS
T
I
P
H
I
L
K
A
Y
L
E
E
ATVG
T
R
I
A
C
L
G
F
G
P
GL
T
A
A
G
L
V
L
E
K
I--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
52.05
9%
-76
- C5 -
3T15
-
RCA1_TOBAC
A:
[68-360]
--------------------------
N
L
D
N
K
L
D
---------
G
---
F
Y
--
I
A
P
A
F
M
----
D
----
K
L
V
V
H
I
----
T
K
N
F
--
L
K
L
P
N
I
K
V
----
P
-
L
----
I
-
L
G
------
I
W
G
--------
G
------------
K
G
Q
G
K
S
--
F
Q
C
E
L
-
V
F
R
K
M
G
-
I
N
-------
P
I
M
M
S
--------
A
-
G
E
L
E
S
G
E
-
P
A
K
---
L
I
R
Q
-----
R
Y
R
-
E
A
------
A
E
----------
I
--
I
--
R
K
-----------------------
G
N
-
M
C
-----------
C
-----
L
F
-----------------
I
---
N
-
D
L
D
N
N
Q
---
M
V
N
A
--
T
L
--
M
N
I
A
D
N
P
T
E
N
--------
A
R
V
P
I
I
V
T
G
-
N
D
F
S
T
----------------
A
-
P
L
I
R
D
------
G
R
M
E
K
F
Y
W
A
P
T
R
E
D
----
R
I
---
G
V
C
T
G
I
F
R
T
D
N
V
-------
P
A
E
D
V
-
V
K
I
V
D
N
F
P
GQS
I
D
-
F
----
F
G
--
A
----
L
-------
R
A
R
V
Y
D
D
E
V
-----
R
K
---
W
V
-----
S
G
-----
T
G
I
E
-
K
I
-
G
D
K
L
---
L
-
N
-------------------------
S
F
D
G
P
P
T
F
E
Q
P
K
M
-----------------
T
---
I
E
K
L
L
E
---
Y
-------
G
N
M
L
V
Q
E
Q
----------
E
N
V
K
R
V
Q
L
A
D
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
49.22
21%
-9
- C7 -
3F2E
1
?
A:
[8-89]
---------------------------------------------------------------------------------------------------------------
F
T
--------
A
V
A
-------
E
Q
V
S
A
V
L
S
Q
--
Y
G
I
T
G
-
P
N
R
A
I
Y
-
Q
G
-------
F
G
L
K
V
--------
A
-
R
A
L
N
R
L
G
-
G
G
P
---
A
L
V
N
-----
M
I
N
-
G
L
------
K
A
Y
Y
I
S
AFNAN
P
T
--
V
--
L
D
A
V
T
D
----
I
I
T
---
G
------
S
P
T
G
-
Y
V
-----------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
46.78
23%
-26
- C7 -
2LCK
-
UCP2_MOUSE
A:
[113-303]
-------------------------------
H
A
G
I
--
G
S
R
L
L
A
---
G
S
--
T
T
G
A
L
A
----
V
----
A
V
A
Q
P
T
----
D
V
V
K
V
R
F
Q
A
Q
A
R
A
G
----
G
--------
G
R
------
R
Y
Q
--------
S
T
V
-------
E
A
Y
K
T
I
A
R
E
--
E
G
I
R
G
-
L
W
K
G
T
S
-
P
N
-------
V
A
R
N
A
--------
I
-
V
N
C
A
E
L
V
-
T
Y
D
---
L
I
K
D
-----
T
L
L
-
K
A
------
N
L
----------
M
--
T
--
D
D
L
P
C
H
----
F
T
S
---
A
------
F
G
A
G
-
F
C
-----------
T
-----
T
V
-----------------
I
---
A
-
S
P
V
D
V
V
---
K
T
R
Y
--
M
N
--
S
A
L
G
-----
Q
Y
H
---
S
A
G
H
C
A
L
T
M
L
R
K
-
E
G
P
R
A
F
----
Y
K
-
G
F
M
-----
P
-
S
F
L
R
L
------
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
----
K
R
---
A
L
M
A
A
Y
Q
S
R
E
A
P
-------
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
46.08
18%
-63
- C4 -
4OO3
-
?
A:
[3-441]
--EGFTGAPGE
V
K
L
I
T
L
DPGH
F
H
A
A
L
V
Q
K
V
S
Y
P
Q
V
SK
D
V
Y
V
Y
A
P
T
G
F
D
--
V
D
E
H
L
K
----
R
----
I
Q
G
F
N
T
RAEN
P
T
A
W
N
E
I
V
Y
T
G
D
D
Y
----
L
-
E
----
K
M
L
A
------
E
K
K
--------
G
N
V
M
I
Q
A
G
NN
G
K
K
T
E
Y
I
K
K
T
L
E
A
G
I
N
-
V
L
S
D
K
P
M
A
I
N
S
Q
S
F
K
L
L
E
E
C
F
--------
A
-
I
A
K
Q
K
N
I
M
L
Y
D
I
MT
E
R
N
E
-----
I
T
T
M
L
Q
------
R
E
----------
L
--
S
T
I
P
A
V
Y
G
E
----
Q
L
K
---
G
SPEEPA
I
V
K
E
-
S
V
-----------
H
-----
H
L
F
K
L
V
DN
K
P
L
T
R
P
VWYLD
V
---
N
-
Q
Q
G
E
G
I
VD
V
T
T
H
L
--
V
D
--
L
V
Q
W
E
A
F
P
D
Q
I
I
---
D
Y
R
K
D
I
E
L
I
D
A
N
-
R
W
T
T
S
I
S
P
E
E
F
K
-
Q
V
T
GTDAY
P
-
D
F
L
K
K
DVEND
T
L
K
V
Y
C
N
G
D
I
V
Y
K
I
-----
K
G
---
V
T
A
K
V
S
V
I
W
N
Y
T
FPKGG
G
D
T
H
F
S
V
M
K
G
S
K
A
D
L
V
---
I
R
-
Q
----
G
K
--
E
----
Q
NY
Q
P
E
L
F
V
E
A
V
K
G
V
D
L
-----
A
A
---
Y
E
-----
K
D
-----
L
T
A
S
M
E
K
-
V
S
A
E
YPG
V
-
A
-------------------------
L
N
K
V
G
D
G
V
W
Q
V
E
I
P
A
K
Y
R
V
----------
G
H
E
A
H
F
G
Q
V
T
E
---
H
-------
F
L
D
Y
L
K
E
G
KLPDW
E
V
P
N
M
L
A
K
Y
Y
T
T
T
S
A
L
D
M
A
K
A
K
T----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
41.40
12%
9
- C7 -
3F2E
1
?
A:
[8-60]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
A
V
-
A
E
-
Q
V
S
A
---
V
-
L
-------------------------
S
Q
Y
G
I
T
G
P
N
R
A
I
Y
Q
G
F
G
L
K
----------
V
A
---
R
A
L
N
R
L
---
G
-------
G
G
P
A
L
V
N
M
----------
I
N
G
L
K
A
Y
Y
I
S
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
41.02
12%
-21
- C2 -
2P7N
-
?
A:
[47-392]
----------------------
P
A
L
A
A
A
R
A
K
A
D
E
L
--
G
Q
A
A
R
E
---
V
R
--
A
S
V
E
R
Q
----
T
----
A
Y
E
T
R
L
----
A
A
Q
R
S
A
A
A
F
S
G
G
E
P
----
P
-
A
----
R
-
R
E
------
A
P
G
--------
A
E
L
-------
D
E
-
A
R
N
A
Q
T
--
V
S
A
R
L
-
F
E
G
N
L
K
-
G
V
-------
A
Q
S
G
H
--------
A
M
S
A
E
Q
K
Q
A
-
L
Q
S
---
G
L
D
D
-----
V
F
A
-
D
A
------
P
P
----------
Q
--
A
--
R
S
A
G
A
P
M
L
Y
S
A
N
A
---
A
------
A
G
Q
G
M
A
D
-----------
S
-----
D
L
-----------------
W
---
D
M
I
S
D
Q
I
G
---
K
I
K
D
--
N
Y
--
L
G
V
Y
E
N
V
V
G
Q
Y
T
---
D
F
Y
K
A
F
S
D
I
L
S
Q
M
A
N
W
I
K
L
----
N
V
-
D
A
L
-----
K
-
A
A
L
E
K
------
L
K
K
D
F
S
L
G
D
N
L
D
N
K
----
K
A
---
V
L
F
P
A
Q
S
K
D
G
G
I
-------
Q
G
G
S
--
E
S
D
A
R
K
W
A
---
K
E
M
G
----
L
P
--
D
----
A
-------
P
P
P
G
F
S
C
V
Q
-----
K
A
---
A
D
-----
G
N
-----
W
V
V
V
-
V
D
M
T
P
I
D
---
T
M
I
-------------------------
R
D
V
G
A
L
G
S
-
G
T
L
E
L
D
N
A
K
F
----------
Q
A
---
W
Q
S
G
F
K
---
A
-------
Q
E
E
N
L
K
N
T
----------
L
Q
T
L
T
Q
K
Y
S
N
A
N
S
L
F
D
N
L
V
K
V
L
S
S
T
I
S
S
C
L
ET--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------