@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UCP2_HUMAN: (2015-12-12 )
MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAACTSREAPF
Atome Classification :
(20 SA)
--.........10...---.....20------------------........30-----........40-----.........50........60.......--------------------------..70..---.......80....-----------.....-90------------------........100.......110---.-----....---..----..120....-----.....130.......140.......150-.---.-..-.--...160.......170..--.-.....180----....-..----------------.190--......--------..-200---.....--...210--...-..---------------------------..-..220.....-------..230--.----.------..-------------------.---..240.-----....-.-----.---250.-........260...---....270......------.--280.-------------......290------------.........300..---.-....---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MVGFKATDVPPT
A
T
---
V
K
F
LGA
G
------------------
T
A
A
C
I
A
D
L
I
T-----FPLD
T
A
K
V
R
------
L
Q
I
QGESQGPVRATASA
Q
Y
R
-
G
V
M
G
T
I
L
--------------------------
T
M
V-RT---EG
P
R
S
L
Y
N
-
G
L
V
A
-----------
G
L
Q
R
Q
-
M
S
------------------
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
Y
TKG-----S-----E
H
A
S
---
I
G
----
S
R
L
--LAGS-----TT
G
A
L
A
V
A
VAQPT
D
V
V
K
V
R
F
Q
A
Q
ARA-G-G---G-
R
R
-
Y
--
Q
S
T
V
N
A
Y
K
T
I
A
R
E
EG-
F
R
--G-LWKGTSP
N
----
V
A
R
N
-
A
I
----------------
V
N
C
---
A
E
L
V
T
Y
--------
D
L
-
I
K
----
D
A
L
L
K
--ANLM----TDD-LP---------------------------C
H
-
F
T
S
A
FGA
G
F
C
-------
T
T
V
IA--S----
P
------
V
D
-------------------
V
---
V
K
T
R
Y
M
-----
N
S
A
L
-G-----Q---Y--S-SA
G
H
C
A
L
T
M
L
QKEG---
P
R
A
F
Y
K
G
F
M
P
S
F
L
------R--LGSW-------------
N
V
V
M
F
V
T
--------------
Y
E
Q
L
K
R
A
L
M
A
A
C
TS---R-EAPF---
14
HHSearch
80.56
96%
-66
- C5 -
2LCK
-
UCP2_MOUSE
A:
[14-308]
---------------
T
---
V
K
F
L
G
A
G
------------------
T
A
A
C
I
A
D
L
I
T
-----
F
P
L
D
T
A
K
V
R
------
L
Q
I
Q
G
E
S
Q
G
L
V
R
T
A
A
S
A
Q
Y
R
-
G
V
L
G
T
I
L
--------------------------
T
M
V
-
R
T
---
E
G
P
R
S
L
Y
N
-
G
L
V
A
-----------
G
L
Q
R
Q
-
M
S
------------------
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
Y
T
K
G
-----
S
-----
E
H
A
G
---
I
G
----
S
R
L
--
L
A
G
S
-----
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
V
V
K
V
R
F
Q
A
Q
A
R
A
-
G
-
G
---
G
-
R
R
-
Y
--
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
-
I
R
--
G
-
L
W
K
G
T
S
P
N
----
V
A
R
N
-
A
I
----------------
V
N
C
---
A
E
L
V
T
Y
--------
D
L
-
I
K
----
D
T
L
L
K
--
A
N
L
M
----
T
D
D
-
L
P
---------------------------
C
H
-
F
T
S
A
F
G
A
G
F
C
-------
T
T
V
I
A
--
S
----
P
------
V
D
-------------------
V
---
V
K
T
R
Y
M
-----
N
S
A
L
-
G
-----
Q
---
Y
--
H
-
S
A
G
H
C
A
L
T
M
L
R
K
E
G
---
P
R
A
F
Y
K
G
F
M
P
S
F
L
------
R
--
L
G
S
W
-------------
N
V
V
M
F
V
T
--------------
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
---
R
-
E
A
P
F
---
1
PsiBlast_PDB
80.44
95%
-67
- C5 -
2LCK
-
UCP2_MOUSE
A:
[14-309]
---------------
T
---
V
K
F
L
G
A
G
------------------
T
A
A
C
I
A
D
L
I
T
-----
F
P
L
D
T
A
K
V
R
------
L
Q
I
Q
G
E
S
Q
G
L
V
R
T
A
A
S
A
Q
Y
R
-
G
V
L
G
T
I
L
--------------------------
T
M
V
-
R
T
---
E
G
P
R
S
L
Y
N
-
G
L
V
A
-----------
G
L
Q
R
Q
-
M
S
------------------
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
Y
T
K
G
-----
S
-----
E
H
A
G
---
I
G
----
S
R
L
--
L
A
G
S
-----
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
V
V
K
V
R
F
Q
A
Q
A
R
A
-
G
-
G
---
G
-
R
R
-
Y
--
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
-
I
R
--
G
-
L
W
K
G
T
S
P
N
----
V
A
R
N
-
A
I
----------------
V
N
C
---
A
E
L
V
T
Y
--------
D
L
-
I
K
----
D
T
L
L
K
--
A
N
L
M
----
T
D
D
-
L
P
---------------------------
C
H
-
F
T
S
A
F
G
A
G
F
C
-------
T
T
V
I
A
--
S
----
P
------
V
D
-------------------
V
---
V
K
T
R
Y
M
-----
N
S
A
L
-
G
-----
Q
---
Y
--
H
-
S
A
G
H
C
A
L
T
M
L
R
K
E
G
---
P
R
A
F
Y
K
G
F
M
P
S
F
L
------
R
--
L
G
S
W
-------------
N
V
V
M
F
V
T
--------------
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
---
R
-
E
A
P
F
---
3
PsiBlast_PDB
70.78
25%
-47
- C5 -
2C3E
4
ADT1_BOVIN
A:
[11-293]
---------------------
F
L
A
G
G
------------------
V
A
A
A
I
S
K
T
A
V
-----
A
P
I
E
R
V
K
L
L
------
L
Q
V
Q
H
A
S
K
---
Q
I
S
A
E
K
Q
Y
K
-
G
I
I
D
C
V
V
--------------------------
R
I
P
-
K
E
---
Q
G
F
L
S
F
W
R
-
G
N
L
A
-----------
N
V
I
R
Y
-
F
P
------------------
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
-----
V
-----
D
R
H
K
---
Q
F
----
W
R
Y
--
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
-
G
-
A
---
A
-
Q
R
E
F
--
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
-
L
R
--
G
-
L
Y
Q
G
F
N
V
S
----
V
Q
G
I
-
I
I
----------------
Y
R
A
---
A
Y
F
G
V
Y
--------
D
T
-
A
K
------------
G
M
L
----
P
D
P
-
K
N
---------------------------
V
H
-
I
I
V
S
W
M
I
A
Q
T
-------
V
T
A
V
A
--
G
L
V
S
Y
P
------
F
D
-------------------
T
---
V
R
R
R
M
M
M
Q
SGR
K
G
A
D
-
I
-----
M
---
Y
--
T
-
G
T
V
D
C
W
R
K
I
A
K
D
E
G
---
P
K
A
F
F
K
G
A
W
S
N
V
L
------
R
---
G
M
G
-------------
G
A
F
V
L
V
L
--------------
Y
D
E
I
----------------------
2
PsiBlast_PDB
68.71
25%
-43
- C5 -
1OKC
10
ADT1_BOVIN
A:
[11-293]
---------------------
F
L
A
G
G
------------------
V
A
A
A
I
S
K
T
A
V
-----
A
P
I
E
R
V
K
L
L
------
L
Q
V
Q
H
A
S
K
---
Q
I
S
A
E
K
Q
Y
K
-
G
I
I
D
C
V
V
--------------------------
R
I
P
-
K
E
---
Q
G
F
L
S
F
W
R
-
G
N
L
A
-----------
N
V
I
R
Y
-
F
P
------------------
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
-----
V
-----
D
R
H
K
---
Q
F
----
W
R
Y
--
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
-
G
-
A
---
A
-
Q
R
E
F
--
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
-
L
R
--
G
-
L
Y
Q
G
F
N
V
S
----
V
Q
G
I
-
I
I
----------------
Y
R
A
---
A
Y
F
G
V
Y
--------
D
T
-
A
K
------------
G
M
L
----
P
D
P
-
K
N
---------------------------
V
H
-
I
I
V
S
W
M
I
A
Q
T
-------
V
T
A
V
A
--
G
L
V
S
Y
P
------
F
D
-------------------
T
---
V
R
R
R
M
M
M
Q
SGR
K
G
A
D
-
I
-----
M
---
Y
--
T
-
G
T
V
D
C
W
R
K
I
A
K
D
E
G
---
P
K
A
F
F
K
G
A
W
S
N
V
L
------
R
---
G
M
G
-------------
G
A
F
V
L
V
L
--------------
Y
D
E
I
----------------------
4
PsiBlast_PDB
66.70
25%
-37
- C5 -
4C9H
5
ADT2_YEAST
A:
[25-313]
-------------------
I
D
F
L
M
G
G
------------------
V
S
A
A
V
A
K
T
A
A
-----
S
P
I
E
--
R
V
K
------
L
L
I
Q
N
Q
D
E
M
L
K
Q
G
T
L
D
R
K
Y
A
-
G
I
L
D
C
F
K
--------------------------
R
T
A
-
T
Q
---
E
G
V
I
S
F
W
R
-
G
N
T
A
-----------
N
V
I
R
Y
-
F
P
------------------
T
Q
A
L
N
F
A
F
K
D
K
I
K
A
M
F
G
F
K
-----
K
-----
E
E
G
Y
A
K
W
F
A
----
G
N
L
--
A
S
G
G
-----
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
Y
A
R
T
R
L
A
A
D
S
---------
A
-
R
Q
-
F
--
N
G
L
I
D
V
Y
K
K
T
L
K
S
D
G
-
V
A
--
G
-
L
Y
R
G
F
L
P
S
----
V
V
G
I
-
V
V
----------------
Y
R
G
---
L
Y
F
G
M
Y
--------
D
S
-
L
K
--------------------------------------------------------
L
A
S
F
L
L
G
W
V
-------
V
T
T
G
A
--
S
T
C
S
Y
P
------
L
D
-------------------
T
---
V
R
R
R
M
M
-----
M
T
S
--
G
-----
Q
AVK
Y
--
D
-
G
A
F
D
C
L
R
K
I
V
A
A
E
G
---
V
G
S
L
F
K
G
C
G
A
N
I
L
------
R
---
G
V
A
-------------
G
A
G
V
I
S
M
--------------
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
------------
15
HHSearch
64.08
25%
-41
- C5 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
---------
D
Q
A
L
S
F
L
---
K
D
F
L
A
G
G
------------------
V
A
A
A
I
S
K
T
A
V
-----
A
P
I
E
R
V
K
L
L
------
L
Q
V
Q
H
A
S
K
Q
I
S
---
A
E
K
Q
Y
K
-
G
I
I
D
C
V
V
--------------------------
R
I
P
-
K
E
---
Q
G
F
L
S
F
W
R
-
G
N
L
A
-----------
N
V
I
R
Y
-
F
P
------------------
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
-----
V
DRHKQ
F
W
R
Y
---
F
A
----
G
N
L
--
A
S
G
G
-----
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
-
G
A
A
---
Q
-
R
E
-
F
--
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
-
L
R
--
G
-
L
Y
Q
G
F
N
V
S
----
V
Q
G
I
-
I
I
----------------
Y
R
A
---
A
Y
F
G
V
Y
--------
D
T
-
A
K
----
G
M
L
P
D
--
P
K
------
N
V
H
-
I
I
---------------------------
V
S
-
W
M
I
A
Q
T
V
T
A
V
-------
A
G
L
V
S
--
Y
----
P
------
F
D
-------------------
T
---
V
R
R
R
M
M
-----
M
Q
S
G
-
R
KGADI
M
---
Y
--
T
-
G
T
V
D
C
W
R
K
I
A
K
D
E
G
---
P
K
A
F
F
K
G
A
W
S
N
V
L
------
R
--
G
M
G
--------------
G
A
F
V
L
V
L
--------------
Y
D
E
I
----------------------
24
Fugue
63.98
24%
-42
* C5 *
1OKC
10
ADT1_BOVIN
A:
[2-293]
---------
D
Q
A
L
S
F
L
---
K
D
F
L
A
G
G
------------------
V
A
A
A
I
S
K
T
A
V
-----
A
P
I
E
R
V
K
L
L
------
L
Q
V
Q
H
A
S
K
---
Q
I
S
A
E
K
Q
Y
K
-
G
I
I
D
C
V
V
--------------------------
R
I
P
-
K
E
---
Q
G
F
L
S
F
W
R
-
G
N
L
A
-----------
N
V
I
R
Y
-
F
P
------------------
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
F
L
G
G
VDRHK
Q
-----
F
W
R
Y
---
F
A
----
G
N
L
--
A
S
G
G
-----
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
-
G
-
A
---
A
Q
R
E
-
F
--
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
-
L
R
--
G
-
L
Y
Q
G
F
N
V
S
----
V
Q
G
I
-
I
I
----------------
Y
R
A
---
A
Y
F
G
V
Y
--------
D
T
-
A
K
----
G
M
L
P
D
--
P
K
------
N
V
H
-
I
I
---------------------------
V
S
-
W
M
I
A
Q
T
V
T
A
V
-------
A
G
L
V
S
--
Y
----
P
------
F
D
-------------------
T
---
V
R
R
R
M
M
M
Q
SGR
K
G
A
D
-
I
-----
M
---
Y
--
T
-
G
T
V
D
C
W
R
K
I
A
K
D
E
G
---
P
K
A
F
F
K
G
A
W
S
N
V
L
------
R
--
G
M
G
--------------
G
A
F
V
L
V
L
--------------
Y
D
E
I
----------------------
6
PsiBlast_PDB
61.02
25%
-36
- C5 -
4C9Q
5
ADT3_YEAST
A:
[19-316]
---------
D
A
K
Q
Q
E
T
N
F
A
I
N
F
L
M
G
G
------------------
V
S
A
A
I
A
K
T
A
A
-----
S
P
I
E
--
R
V
K
------
I
L
I
Q
N
Q
D
E
M
I
K
Q
G
T
L
D
K
K
Y
S
-
G
I
V
D
C
F
K
--------------------------
R
T
A
-
K
Q
---
E
G
L
I
S
F
W
R
-
G
N
T
A
-----------
N
V
I
R
Y
-
F
P
------------------
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
M
F
G
F
K
-----
K
-----
E
-
G
Y
G
K
W
F
A
----
G
N
L
--
A
S
G
G
-----
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
D
A
K
S
-------
A
-
R
Q
-
F
--
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
-
I
A
--
G
-
L
Y
R
G
F
M
P
S
----
V
V
G
I
-
V
V
----------------
Y
R
G
---
L
Y
F
G
M
F
--------
D
S
-
L
K
----
P
L
-------------------------------------------------
F
L
A
S
F
L
L
G
W
V
-------
V
T
T
G
A
--
S
T
C
S
Y
P
------
L
D
-------------------
T
---
V
R
R
R
M
M
-----
M
T
S
--
G
-----
Q
AVK
Y
--
N
-
G
A
I
D
C
L
K
K
I
V
A
S
E
G
---
V
G
S
L
F
K
G
C
G
A
N
I
L
------
R
S
V
A
G
A
G
-------------
V
I
S
M
-----------------
Y
D
Q
L
Q
M
I
L
F
G
K
---------------
5
PsiBlast_PDB
60.57
25%
-34
- C5 -
4C9J
4
ADT3_YEAST
A:
[25-316]
---------------
T
N
F
A
I
N
F
L
M
G
G
------------------
V
S
A
A
I
A
K
T
A
A
-----
S
P
I
E
--
R
V
K
------
I
L
I
Q
N
Q
D
E
M
I
K
Q
G
T
L
D
K
K
Y
S
-
G
I
V
D
C
F
K
--------------------------
R
T
A
-
K
Q
---
E
G
L
I
S
F
W
R
-
G
N
T
A
-----------
N
V
I
R
Y
-
F
P
------------------
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
M
F
G
F
K
-----
K
-----
E
E
G
Y
G
K
W
F
A
----
G
N
L
--
A
S
G
G
-----
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
R
L
A
A
D
A
K
S
-------
A
-
R
Q
-
F
--
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
-
I
A
--
G
-
L
Y
R
G
F
M
P
S
----
V
V
G
I
-
V
V
----------------
Y
R
G
---
L
Y
F
G
M
F
--------
D
S
-
L
K
-----------------------------------------------------------
F
L
L
G
W
V
-------
V
T
T
G
A
--
S
T
C
S
Y
P
------
L
D
-------------------
T
---
V
R
R
R
M
M
-----
M
T
S
--
G
-----
Q
AVK
Y
--
N
-
G
A
I
D
C
L
K
K
I
V
A
S
E
G
---
V
G
S
L
F
K
G
C
G
A
N
I
L
------
R
S
V
A
G
A
G
-------------
V
I
S
M
-----------------
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
-------------
25
Fugue
57.64
21%
-62
- C1 -
4FDW
-
?
A:
[21-401]
AS
L
E
D
F
S
I
E
Q
L
P
A
K
-
T
---
I
Y
A
L
G
E
N
IDLTG
L
N
V
T
G
K
Y
DDG
K
Q
R
P
V
K
V
T
S
E
Q
I
S
GFSSS
V
P
V
D
K
Q
E
V
T
------
I
T
I
E
G
K
Q
K
S
F
S
V
H
I
S
P
V
R
V
E
N
G
V
L
T
E
I
L
K
GYN
E
I
I
L
P
NSVKSIPKDAFRNSQIA
K
V
V
-
L
N
---
E
G
L
K
S
I
G
D
M
A
F
F
N
-----------
S
T
V
Q
E
-
I
V
------------------
F
P
S
T
L
E
Q
L
K
E
D
I
-
F
Y
Y
C
Y
N
-----
L
-----
K
K
A
D
---
L
S
KTKI
T
K
L
--
P
A
S
T
-----
F
V
Y
A
G
I
E
E
V
L
L
P
V
T
L
K
E
I
G
S
Q
A
F
L
K
T
-
S
-
Q
---
L
-
K
T
-
I
--
E
I
P
E
N
V
-
S
T
I
G
Q
E
-
A
-
F
R
ES
G
-
I
T
T
V
K
L
P
N
GVTN
I
A
S
R
-
A
F
----------------
Y
Y
C
PEL
A
E
V
T
T
Y
G
STFNDDP
E
A
M
I
H
----
P
Y
C
L
E
GC
P
K
L
A
----
R
F
E
-
I
P
----------------------------
E
-
S
I
R
I
L
G
Q
G
L
L
GGNRKVT
Q
L
T
I
P
--
A
----
N
------
V
T
-------------------
Q
---
I
N
------------------------
F
--
S
-
A
F
N
N
T
G
I
K
E
V
K
V
E
G
TTP
P
Q
V
F
E
K
V
W
Y
G
F
P
D
------
D
--
I
T
V
I
-------------
R
V
P
A
E
S
V
--------------
E
K
Y
K
N
A
N
G
W
R
D
F
T
N
---
K
-
I
T
T
F
---
31
Fugue
52.22
16%
-70
- C4 -
4LUQ
-
?
A:
[20-428]
-----------
H
M
T
A
T
---
S
D
L
I
E
S
L
------------------
I
S
Y
S
W
D
D
W
Q
V
-----
T
R
Q
E
A
R
R
V
I
------
A
A
I
R
N
D
N
V
-
P
D
A
T
I
A
A
L
D
K
S
-
G
S
L
I
K
L
F
--------------------------
Q
R
V
G
P
P
---
E
L
A
R
S
L
I
A
-
S
I
A
G
R
TTMQ
R
Y
Q
A
R
N
A
L
I
R
S
-
L
I
NNPLGTQTDNWIYFP
T
I
T
F
F
D
I
C
A
D
L
A
D
A
A
G
R
L
G
F
A
A
-----
A
-----
G
A
T
G
---
V
A
----
S
Q
A
--
I
Q
G
P
-----
F
S
G
V
G
A
T
G
V
-
N
P
T
D
L
P
S
I
A
F
G
D
Q
L
K
L
-
L
-
N
---
K
-
D
P
-
A
--
T
V
T
K
Y
S
N
P
L
G
D
L
G
A
Y
-
L
S
--
Q
-
L
S
P
Q
D
K
L
N
----
Q
A
Q
T
-
L
V
G
QPISTLFPDAYPGNP
P
S
R
---
A
K
V
M
S
A
--------
A
A
-
R
K
Y
DLT
P
Q
L
I
G
--
A
I
I
L
----
A
E
Q
-
R
D
QT
R
D
E
D
A
K
D
Y
Q
A
A
V
SIKSAN
T
S
I
G
LGQ
V
V
-
V
S
T
A
I
K
Y
E
L
F
-------
T
D
L
L
G
--
Q
----
P
------
V
R
R
G
LS
R
K
A
V
A
T
L
L
A
S
D
E
F
N
I
F
---
A
T
A
R
Y
I
-----
R
Y
V
A
-
N
-----
L
---
A
--
S
-
Q
Q
D
L
R
K
L
P
K
T
R
G
A
F
---
P
S
I
D
L
R
A
Y
A
G
N
P
R
------
N
--
W
P
R
D
-------------
N
V
R
A
L
A
S
E
Y
T
S
RPWDDNLSPG
W
P
M
F
V
D
D
A
Y
A
T
F
L
D
---
P
-
G
M
R
F
P--
29
Fugue
52.08
13%
-67
- C3 -
1HQC
1
RUVB_THET8
A:
[5-318]
---------
A
L
R
P
K
T
L
---
D
E
Y
I
G
Q
---------------------
E
R
L
K
Q
K
L
R
-----
V
Y
L
E
A
A
K
A
R
KEPLEH
L
L
L
F
G
P
P
-
G
L
G
K
T
T
L
A
H
V
I
A
-
H
E
L
G
V
N
L
--------------------------
R
V
T
-
S
G
PAI
E
K
P
G
D
L
A
A
-
I
L
A
N
-----------
S
L
E
E
G
D
I
L
------------------
F
I
D
E
I
H
R
L
S
R
Q
A
E
E
H
L
Y
P
A
-----
M
-----
E
D
F
V
---
M
D
----
I
V
I
--
G
Q
G
P
-----
A
A
R
T
I
R
L
E
L
P
R
F
T
L
I
G
A
T
T
R
P
G
L
I
T
A
-
P
-
L
---
L
-
S
R
-
F
G
I
V
E
H
L
E
Y
Y
T
P
E
E
L
A
Q
G
-
V
M
--
R
-
D
A
R
L
L
G
V
R
----
I
T
E
E
-
A
A
----------------
L
E
I
---
G
R
R
-
S
R
--------
G
T
-
M
R
----
V
A
K
R
L
--
F
R
R
V
----
R
D
F
-
A
Q
---------------------------
V
A
-
G
E
E
V
I
T
R
E
R
A
-------
L
E
A
L
A
--
A
----
L
GLDELG
L
E
-------------------
K
---
R
D
R
E
I
L
-----
E
V
L
I
-
L
-----
R
---
F
GG
G
-
P
V
G
L
A
T
L
A
T
A
L
S
E
D
---
P
G
T
L
E
E
V
H
E
P
Y
L
I
------
R
--
Q
G
-------------------
L
L
K
--------------
R
T
P
R
G
R
V
P
T
E
L
A
Y
R
H
L
G
Y
-
P
P
P
V
---
17
HHSearch
49.57
22%
-40
- C5 -
1OKC
8
ADT1_BOVIN
A:
[5-205]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
---
F
L
----
K
D
F
--
L
A
G
G
-----
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
V
Q
H
A
S
-
K
-
Q
ISA
E
-
K
Q
-
Y
--
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
-
F
L
--
S
-
F
W
R
G
N
L
A
N
----
V
I
R
Y
-
F
P
----------------
T
Q
A
---
L
N
F
A
F
K
--------
D
K
-
Y
K
----
Q
I
F
L
G
--
G
V
D
R
HKQ
F
W
R
Y
-
F
A
---------------------------
G
N
-
L
A
S
G
G
A
A
G
A
T
-------
S
L
C
F
V
--
Y
----
P
------
L
D
-------------------
F
---
A
R
T
R
L
A
-----
A
D
V
G
-
K
GAAQR
E
---
F
--
T
-
G
L
G
N
C
I
T
K
I
F
K
S
D
G
---
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
------
G
--
I
I
I
Y
-------------
R
A
A
Y
F
G
V
--------------
Y
D
T
A
K
G
M
L
P
D
P
K
N
V
---
H
-
I
I
V
S
---
16
HHSearch
49.33
27%
-23
- C5 -
2LCK
-
UCP2_MOUSE
A:
[113-303]
-----------
H
A
G
I
G
---
S
R
L
L
A
G
S
------------------
T
T
G
A
L
A
V
A
V
A
-----
Q
P
T
D
V
V
K
V
R
------
F
Q
A
Q
A
R
A
G
G
------
G
R
R
Y
Q
-
S
T
V
E
A
Y
K
--------------------------
T
I
A
-
R
E
---
E
G
I
R
G
L
W
K
-
G
T
S
P
-----------
N
V
A
R
N
-
A
I
------------------
V
N
C
A
E
L
V
T
Y
D
L
I
K
D
T
L
L
K
A
-----
N
L----
M
T
D
D
---
L
P
----
C
H
F
--
T
S
A
F
-----
G
A
G
F
C
T
T
V
I
A
S
P
V
D
V
V
K
T
R
Y
M
N
S
A
L
G
----------
Q
-
Y
--
H
S
A
G
H
C
A
L
T
M
L
R
K
E
G
-
P
R
--
A
-
F
Y
K
G
F
M
P
S
----
F
L
R
L
-
G
S
----------------
W
N
V
---
V
M
F
V
T
Y
--------
E
Q
-
L
K
----
R
A
L
M
A
--
A
Y
Q
S
----
R
E
A
-
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
47.18
20%
-47
* C6 *
3G3L
9
?
A:
[10-305]
-----------
P
A
E
A
K
---
Y
Y
I
A
G
-----------------------
T
I
T
D
A
T
T
G----
Q
E
L
T
T
A
K
V
T
------
L
---
G
D
K
S
V
T
S
S
F
N
E
Q
V
N
Y
K
-
A
E
G
Y
A
L
V
--------------------------
V
S
A
-
D
G
---
Y
Y
P
V
K
R
Q
V
-
Y
L
N
Q
-----------
V
S
D
G
Q
-
T
S
------------------
V
A
T
V
N
V
A
L
V
S
V
E
A
A
V
I
P
P
V
-----
V
-----
P
P
T
D
---
P
E
----
T
D
I
N
E
G
E
A
T
-----
K
V
A
D
K
A
V
E
V
A
K
P
S
-------
E
S
T
V
T
D
M
L
-
A
---
G
-
T
-----
T
A
T
P
E
E
K
K
A
L
D
E
T
L
E
M
A
G
--
G
M
K
V
G
E
T
T
P
E
----
V
L
A
D
G
S
I
----------------
L
A
I
---
T
P
V
K
F
T
--------
N
P
-
I
Q
----
D
A
--------------
P
A
M
V
P
---------------------------
Y
F
-
Y
N
E
G
C
E
L
T
G
D
-------
V
K
E
V
A
--
A
----
P
------
V
A
-------------------
V
A
A
D
I
Q
K
A
F
L
-----
S
N
A
A
-
K
-----
A
---
L
--
N
M
N
A
G
-----
F
V
Q
K
I
G
---
Y
T
R
I
S
V
L
N
G
Y
S
I
L
G
Y
T
I
K
G
Q
--
L
V
S
K
-------------
K
L
T
F
L
I
S
---------------
G
K
Y
Y
E
G
I
V
S
Y
Q
K
S
---
V
M
I
Y
P
N
Y
Y
S
33
Fugue
45.37
17%
-53
- C6 -
1E68
-
?
A:
[1-70]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
E
-
F
G
---------------------
I
P
A
A
V
A
G
T
V
L
N
V
V
E
A
G
-----
G
-----
W
V
T
T
---
I
V
----
S
I
L
--
T
A
V
G
------
S
G
G
L
S
L
L
A
A
A
G
R
E
S
I
K
A
Y
L
K
K
E
I
K
K
-
K
-
G
---
K
-
R
A
-
V
--
I
A
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
43.21
26%
-89
- C5 -
1Q20
2
ST2B1_HUMAN
A:
[108-207]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
----
S
S
H
-
L
P
---------------------------
I
Q
I
F
T
K
A
F
F
S
S
K
A
-------
K
V
I
Y
M
G
R
N
----
P
------
R
D
-------------------
V
---
V
V
S
L
Y
H
-----
Y
S
K
I
A
G
-----
Q
---
L
--
K
-
D
P
G
----------
T
---
P
D
Q
F
L
R
D
F
L
K
G
E
V
------
Q
--
F
G
S
W
F
D
H
I
K
G
W
L
R
MKGK
D
N
F
L
F
I
T
--------------
Y
E
E
L
Q
Q
D
L
Q
G
S
V
E
R
---
I
-
C
G
F
L
---
9
PsiBlast_PDB
42.02
26%
-85
- C5 -
1Q22
2
ST2B1_HUMAN
A:
[108-207]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
----
S
S
H
-
L
P
---------------------------
I
Q
I
F
T
K
A
F
F
S
S
K
A
-------
K
V
I
Y
M
G
R
N
----
P
------
R
D
-------------------
V
---
V
V
S
L
Y
H
-----
Y
S
K
I
A
G
-----
Q
---
L
--
K
-
D
P
G
----------
T
---
P
D
Q
F
L
R
D
F
L
K
G
E
V
------
Q
--
F
G
S
W
F
D
H
I
K
G
W
L
R
MKGK
D
N
F
L
F
I
T
--------------
Y
E
E
L
Q
Q
D
L
Q
G
S
V
E
R
---
I
-
C
G
F
L
---
7
PsiBlast_PDB
41.84
26%
-87
- C5 -
1Q1Z
1
ST2B1_HUMAN
A:
[108-207]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
----
S
S
H
-
L
P
---------------------------
I
Q
I
F
T
K
A
F
F
S
S
K
A
-------
K
V
I
Y
M
G
R
N
----
P
------
R
D
-------------------
V
---
V
V
S
L
Y
H
-----
Y
S
K
I
A
G
-----
Q
---
L
--
K
-
D
P
G
----------
T
---
P
D
Q
F
L
R
D
F
L
K
G
E
V
------
Q
--
F
G
S
W
F
D
H
I
K
G
W
L
R
MKGK
D
N
F
L
F
I
T
--------------
Y
E
E
L
Q
Q
D
L
Q
G
S
V
E
R
---
I
-
C
G
F
L
---
10
PsiBlast_PDB
41.20
26%
-79
- C5 -
1Q1Q
3
ST2B1_HUMAN
A:
[106-205]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
----
S
S
H
-
L
P
---------------------------
I
Q
I
F
T
K
A
F
F
S
S
K
A
-------
K
V
I
Y
M
G
R
N
----
P
------
R
D
-------------------
V
---
V
V
S
L
Y
H
-----
Y
S
K
I
A
G
-----
Q
---
L
--
K
-
D
P
G
----------
T
---
P
D
Q
F
L
R
D
F
L
K
G
E
V
------
Q
--
F
G
S
W
F
D
H
I
K
G
W
L
R
MKGK
D
N
F
L
F
I
T
--------------
Y
E
E
L
Q
Q
D
L
Q
G
S
V
E
R
---
I
-
C
G
F
L
---