@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MOT11_HUMAN: (2015-12-08 )
MPAPQRKHRRGGFSHRCFPTPQTAMTPQPAGPPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSFIYIGLPRALPSCGPASPPATPPPETGELLPAPQAVLLSPGGPGSTLDTTC
Atome Classification :
(20 SA)
---.........10........20........30.....-...40........50...--------------.....--60..-.....-.-70----.........---------80........90...---------------.....100........110--........120..---.---.----.-.---.130---.......140....----...150.....----..-160...--.----..-.170...-....180-------......-----------.--------------------------190.-......------.200-------.......210..-..-----.----...220.-----..--..---..230---...-----......240.......250..----------.....260.......270---.......--------.280---.......-----..290.-......300......--------------------------------------------.310..-....------.320....-----...330.......----340...------.---------...350..-...-..360----.---....----------..370.......380-.......-.390.......400..-.....410....---...420.......430-----..----------------------------------......----440.......450.......460.......470-------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MPAP
Q
R
K
HRRGGFSHRCFPTPQTAMTPQPAGPPDGG-
W
G
W
V
V
A
A
A
A
F
A
I
N
G
L
S
Y
G
--------------
L
L
R
S
L--GLA
F
-
P
D
L
A
E
-
H
-
F
-----DRSAQ
D
T
A
W
---------
I
S
A
L
A
L
A
V
Q
Q
AA
S
P
V
---------------
G
S
A
L
S
TR-WGAR
P
V
V
M
V
G
---
G
V
L
A
S
L
G
F
V
F
S
A
F
---
A
---
S
----
D
-
L
---
L
H
L
Y
---
L
G
L
G
L
L
A
G
F
G
W
A
L
V
----
F
A
P
A
L
G
T
L
S
R
Y
----
F
S-RR
R
V
L
A
--
V
----
G
L
-
A
L
TGNG
A
-
S
S
L
L
L
A
P
-------
A
L
Q
L
L
L
-----------
D
--------------------------T-FG-W
R
G
A
L
L
------
L
L
G
A
-------
I
T
L
HLTP
C
-
G
A
L
-
L
L
-----
P
----
L
VLPGDP-----PA--PP---R
S
P
-----
L
A
A
-----
L
G
L
S
L
F
T
R
R
A
F
S
I
F
A
L
G
T
A
LV----------GG
G
Y
F
V
P
Y
VHL
A
P
H
A
L
D
----RGLG
G
Y
G
--------
A
A
-----
L
V
V
A
V
A
A-----MGDAG
A
-
R
L
V
C
G
WLADQGWV
P
L
--------------------------------------------
P
R
L
L
A
V
-
F
G
A
L
------
T
G
L
G
L
W
V
V
-----
G
L
V
PVVGGEESWG----
G
P
L
L
A
A
------
A
---------
V
A
Y
GLSAG-SY
A
-
P
L
V
F
G
----
V
---
L
P
G
L
----------
V
GV
G
G
V
V
Q
A
T
G
L
V
-
M
-
M
L
M
S
L
GG-LLGPPL
S
G
FLRDETG
D
-
F
T
A
S
F
L
LS
G
S
L
I
---
L
SG
S
F
I
Y
I
GL
P
R
ALP------SC----------------------------------GPASPP----ATPPPETGELLPAP
Q
A
V
L
LSPGGPGSTLDTTC--------------------------
12
Fugue
91.47
19%
-109
- C4 -
3WDO
-
?
A:
[1-453]
------------------------
D
Y
K
M
T
P
-
G
E
R
R
A
T
W
G
-
L
G
T
V
F
S
L
R
M
L
G
M
F
-
M
V
L
P
--------------
V
L
T
T
Y
--
G
M
A
L
-
Q
G
------------
A
S
E
A
L
I
G
I
A
---------
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
---------------
G
-
L
L
S
D
R
-
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
L
---
S
---
D
----
S
-
I
---
W
G
I
I
---
L
G
R
A
L
Q
G
S
G
A
I
A
A
A
----
V
M
A
L
L
S
D
L
T
R
E
----
Q
N
-
R
T
K
A
M
A
F
-
I
----
G
V
-
S
F
G
I
T
F
A
-
I
A
M
V
L
G
P
-------
I
I
T
H
K
L
---------------------------------------------
G
L
H
A
------
L
F
W
M
-------
I
A
I
L
A
T
T
G
-
I
A
L
-
T
I
-----
W
----
V
V
P
N
S
S
T
-----
H
V
--
L
N
---
R
E
-----------------
S
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
----------
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
----
V
A
L
P
G
Q
L
--------
A
D
-------
A
G
F
P
A
-----
A
E
H
W
K
V
-
Y
L
A
T
M
L
I
A
F
G
S
V
V
P
F
--------------------------------------------
I
I
Y
A
E
V
-
K
R
K
M
------
K
Q
V
F
V
F
C
V
-----
G
L
I
-
V
V
A
E
I
V
L
W
N
----
A
Q
T
Q
F
W
------
Q
---------
L
V
V
G
V
Q
L
F
-
F
V
A
F
N
L
M
E
A
----
L
---
L
P
S
L
----------
I
S
K
E
S
P
A
G
Y
K
G
T
A
-
M
-
G
V
Y
S
T
S
Q
-
F
L
G
V
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
G
A
M
---
L
A
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
----------------------------------
E
I
P
A
D
I
----
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
DSKVTN
R
F
E
V
E
Q
A
I
R
QAL--------
4
Fugue
85.73
14%
-117
- C4 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
--F
K
P
A
P
H
K
A
R
L
P
A
A
----------------
E
I
D
P
T
Y
R
R
-
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
--------------
V
R
K
N
F
--
A
L
A
M
-
P
Y
L
V
E
-
Q
-------
G
F
S
R
G
D
L
G
F
---------
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
---------------
M
G
S
V
S
D
R
-
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
---
P
----
W
-
A
T
S
S
I
A
V
M
---
F
V
L
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
----
W
S
Q
K
E
R
G
G
I
--
V
----
S
V
-
W
N
C
A
H
N
V
-
G
G
G
I
P
P
L
-------
L
F
L
L
G
M
-----------
A
--------------------------
W
-
F
N
D
W
H
A
A
L
Y
------
M
P
A
F
-------
C
A
I
L
V
A
L
F
-
A
F
A
-
M
M
RDTPQ
S
----
C
G
L
P
P
I
E
-----
E
Y
--
K
N
---
D
T
A
-----
K
Q
I
-----
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
----------
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V---
K
H
F
A
L
D
K
--------
S
S
-----
W
A
Y
F
L
Y
E
-----
Y
A
G
I
P
G
-
T
L
L
C
G
W
M
S
D
K
----
V
--------------------------------------------
F
R
G
N
R
G
-
A
T
G
V
------
F
F
M
T
L
V
T
I
-----
A
T
I
V
Y
W
M
N
P
A
G
N
P
----
T
V
D
M
I
C
------
M
---------
I
V
I
G
F
L
I
Y
-
G
P
V
-
M
L
I
G
L
----
H
---
A
L
E
L
----------
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
-
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
-
D
G
G
F
M
V
M
I
G
G
S
I
---
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
------
R
H
----------------------------------
E
Q
L
L
Q
E
----
L
V
P
-------------------------------------------------------
13
HHSearch
79.35
14%
-119
- C4 -
1PW4
-
GLPT_ECOLI
A:
[22-430]
-----------------------------------
T
Y
R
R
-
L
R
W
Q
I
F
L
G
I
F
F
G
Y
A
A
Y
Y
L
--------------
V
R
K
N
F
--
A
L
A
M
-
P
Y
L
V
--
E
-
Q
-----
G
F
S
R
G
D
L
G
F
---------
A
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
---------------
M
G
S
V
S
D
R
-
S
N
P
R
V
F
L
P
A
G
---
L
I
L
A
A
A
V
M
L
F
M
G
F
---
V
---
P
W
A
T
S
S
-
I
---
A
V
M
F
---
V
L
-
L
F
L
C
G
W
F
Q
G
M
G
----
W
P
P
C
G
R
T
M
V
H
W
----
W
S
Q
K
E
R
G
G
I
--
V
----
S
V
-
W
N
C
A
H
N
V
-
G
G
G
I
P
P
L
-------
L
F
L
L
G
M
-----------
A
W-------------------------
F
-
N
D
-
W
H
A
A
L
Y
------
M
P
A
F
-------
C
A
I
L
V
A
L
F
-
A
F
A
-
M
M
-----
R
----
D
T
P
Q
S
C
G
LPPIE
E
Y
--
K
N
D-------------TAK
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
----------
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
E
V---
K
H
F
A
L
D
K
--------
S
S
-----
W
A
Y
F
L
Y
E
-----
Y
A
G
I
P
G
-
T
L
L
C
G
W
M
S
D
K
V
F
R
G
N
--------------------------------------------
R
G
A
T
G
V
F
F
M
T
L
------
V
T
I
A
T
I
V
Y
-----
W
M
N
P
---
A
G
N
P
T
V
------
D
M
I
C
------
M
---------
I
V
I
G
F
L
I
Y
-
G
P
V
-
M
L
I
G
L
----
H
---
A
L
E
L
----------
A
P
K
K
A
A
G
T
A
A
G
F
T
-
G
-
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
--
W
D
G
G
F
M
V
M
I
G
G
S
---
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
------
R
R
----------------------------------
H
E
Q
L
L
Q
----
E
L
V
P
------------------------------------------------------
6
Fugue
76.73
16%
-100
- C4 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
-----------------------------------------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
A
Q
T
--------------
I
Y
I
P
-----
A
I
-
A
D
M
A
R
-
D
-
L
-----
N
V
R
E
G
A
V
Q
S
---------
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
---------------
Y
G
P
I
S
D
R
-
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
---
T
---
S
----
S
-
L
---
T
V
L
I
---
A
A
S
A
M
Q
G
M
G
T
G
V
G
G
----
V
M
A
R
T
L
P
R
D
L
Y
----
E
R
-
T
Q
L
R
H
A
--
N
----
S
L
-
L
N
M
G
I
L
V
-
S
P
L
L
A
P
L
-------
I
G
G
L
L
D
-----------
T
--------------------------
M
-
W
N
-
W
R
A
C
Y
L
------
F
L
L
V
-------
L
C
A
G
V
T
F
S
-
M
A
R
-
W
M
-----
P
-------
E
T
R
P
-----
V
D
--
A
P
---
R
T
R
-----
L
L
T
-----
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
----------
L
A
G
I
A
A
-
F
E
A
C
S
G
V
L
M
G
----
A
V
L
G
L
S
S
--------
M
T
-----
V
S
I
L
F
I
L
-----
P
I
P
A
A
F
-
F
G
A
W
F
A
G
R
P
N
K
R
F
S
T
--------------------------------------------
L
M
W
Q
S
V
-
I
C
C
L
------
L
A
G
L
L
M
W
I
-----
P
D
W
F
G
V
M
N
V
W
T
L
L
----
V
P
A
A
L
F
------
F
---------
F
G
A
G
M
L
F
P
-
L
A
T
-
S
G
A
M
E
----
P
---
F
P
F
L
----------
A
G
-----
T
A
G
A
L
V
-
G
-
G
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
-
S
L
G
L
L
M
T
L
M
G
L
L
---
I
V
L
C
W
L
P
L
---------------------------------------------------------------------------------------------------------------------
16
HHSearch
76.68
20%
-92
- C4 -
2GFP
-
EMRD_ECOLI
A:
[19-360]
------------------------------------------------------
V
G
Q
M
--------------
A
Q
T
I
Y
--
I
P
A
I
-
A
D
M
A
R
-
D
-
L
-----
N
V
R
E
G
A
V
Q
S
---------
V
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
---------------
Y
G
P
I
S
D
R
-
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
---
T
---
S
----
S
-
L
---
T
V
L
I
---
A
A
-
S
A
M
Q
G
M
G
T
G
V
G
----
G
V
M
A
R
T
L
P
R
D
L
----
Y
E
R
T
Q
L
R
H
A
--
N
----
S
L
-
L
N
M
G
I
L
V
-
S
P
L
L
A
P
L
-------
I
G
G
L
L
D
-----------
T
--------------------------
M
-
W
N
-
W
R
A
C
Y
L
------
F
L
L
V
-------
L
C
A
G
V
T
F
S
-
M
A
R
-
W
M
-----
P
----
E
T
R
P
V
D
A
-----
P
--------
R
T
R
-----
L
L
T
-----
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
----------
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
A
V
---
L
G
L
S
S
M
T
--------
V
S
-----
I
L
F
I
L
P
I
-----
P
A
A
F
F
G
-
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
---------------------------------------------
W
Q
S
V
I
-
C
C
L
L
------
A
G
L
L
M
W
I
P
-----
D
W
F
---
G
V
M
N
V
W
T
------
L
L
V
P
------
A
---------
A
L
F
F
F
G
A
G
-
M
L
F
-
P
L
A
T
S
----
G
---
A
M
E
P
----------
F
P
-
F
L
A
G
T
A
G
A
L
V
-
G
-
G
L
Q
N
I
G
S
-
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
-
S
L
G
L
L
M
T
L
M
G
L
L
---
I
V
L
C
W
L
P
L
---------------------------------------------------------------------------------------------------------------------
9
Fugue
73.36
19%
-114
- C4 -
4RDQ
3
?
A:
[1-366]
TVT
Y
T
N
R
V
A
D
A
R
L
G
T
F
S
Q
L
L
L
Q
------------------
W
K
G
S
I
Y
K
L
L
Y
S
E
F
L
I
F
I
S
--------------
L
Y
F
A
I
--
S
L
V
Y
-
R
L
I
------------
L
S
E
S
Q
R
L
M
---------
F
E
K
L
A
L
Y
C
N
S
Y
A
E
----------------------------------------
L
I
P
V
S
F
V
L
G
F
Y
---
V
---
S
----
L
-
V
---
V
S
R
W
---
W
A
Q
Y
E
---------------------
S
I
P
----
W
P
-
D
R
I
M
N
L
--
V
----
S
C
-
N
V
D
G
E
D
------------------------------------------------------------------
E
Y
G
R
L
------
L
R
R
T
-------
L
M
R
Y
S
N
L
C
-
S
V
L
-
I
L
-----
R
----
S
V
S
T
A
V
Y
-----
K
R
--
F
P
----
S
M
-----
E
H
V
-----
V
R
A
G
L
M
T
P
E
E
H
K
K
F
E
S
L
N
S
P
-----------
H
N
K
F
W
I
P
C
V
W
F
S
N
L
A
V
K
----
A
R
N
E
G
R
I
--------
R
D
-----
S
V
L
L
Q
G
I
-----
L
N
E
L
N
T
L
R
S
Q
C
G
R
L
Y
G
Y
D
W
I
S
I
--------------------------------------------
P
---
L
V
-
Y
T
Q
V
------
V
T
V
A
V
Y
S
F
-----
F
L
A
C
L
I
G
R
Q
----------
F
L
D
P
------
E
---------
K
A
Y
------------------------
P
G
H
----------
E
L
D
L
F
V
P
V
F
T
F
L
Q
-
F
-
F
F
Y
A
G
W
L
-
K
V
A
E
Q
L
I
N
P
F
G
E
D
D
D
D
-
F
E
T
N
W
L
I
D
R
N
L
Q
---
V
S
L
M
A
V
D
-
E
M
H
Q
D
L
P
------
I
L
----------------------------------
E
K
D
L
Y
W
----
N
E
P
D
P
Q
P
P
--
Y
T
A
A
T
A
E
Y
K
R
P
S
F
L
G
S
T
F
D
I
S
---------------------------
8
Fugue
73.24
19%
-97
- C4 -
4WGV
-
?
A:
[5-399]
------------------
V
G
Y
M
D
P
G
N
W
I
T
S
M
Q
G
G
A
Q
Y
G
Y
T
L
L
F
V
I
L
I
S
S
L
A
A
M
L
L
Q
S
M
--------------
T
V
R
-
L
--
G
I
A
T
G
K
D
L
A
Q
-
M
-
T
R
H
F
L
S
K
P
V
A
I
I
F
W
I
---------
I
A
E
L
A
I
I
A
T
D
I
A
E
V
I
---------------
G
S
A
I
A
L
D
-
L
I
F
G
I
P
L
I
V
G
---
A
L
I
T
----
V
F
D
V
F
---
L
---
L
----
L
-
F
---
I
M
R
F
---
G
F
R
K
I
E
A
I
V
G
T
L
I
F
----
T
V
L
A
I
F
V
F
E
V
F
----
I
S
-
S
P
Q
L
T
D
--
I
--------
L
N
G
F
V
P
-
H
K
E
I
V
T
N
--------
Q
G
I
L
Y
-----------
I
--------------------------
A
-
L
G
-
I
I
G
A
T
I
------
M
P
H
N
-------
L
Y
L
H
S
S
I
V
-
Q
S
R
-
K
Y
-----
D
----
R
--
H
D
N
E
-----
E
K
--
A
Q
---
A
I
K
-----
Y
A
T
-----
I
D
S
N
L
Q
L
S
I
A
F
V
V
N
C
L
L
L
T
L
G
----------
A
A
L
F
F
--------
G
T
K
T
----
N
D
L
G
G
-------------------------------------------------------------------------------------------------
F
Y
D
L
-
Y
H
A
L
------
K
T
E
-------------
P
V
L
G
--
A
T
L
G
----
G
V
M
S
T
L
------
F
---------
A
V
A
L
L
A
S
G
-
Q
N
S
-
T
I
T
G
T
----
L
---
A
G
Q
I
----------
V
M
E
G
F
L
R
L
S
I
P
N
W
-
L
-
R
R
L
I
T
R
S
-
L
A
V
I
P
V
I
I
C
L
I
I
F
K
G
N
----
S
E
K
I
E
Q
L
L
V
---
F
S
Q
V
F
L
S
I
A
L
P
F
S
L
I
------
P
L
----------------------------------
Q
L
A
T
S
N
KKLM
G
P
F
I
N
K
T
W
V
N
I
I
S
W
T
L
I
V
I
L
S
G
L
N
V
Y
--------------------------------
14
HHSearch
72.53
15%
-113
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[32-421]
-------------------------------------------------
C
S
L
F
F
L
W
A
V
--------------
A
N
N
L
N
--
D
I
L
L
-
P
Q
F
Q
Q
-
A
-
F
-----
T
L
T
N
F
Q
A
G
L
---------
I
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
---------------
A
G
I
L
M
K
K
-
L
S
Y
K
A
G
I
I
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
W
P
---
A
A
E
I
M
----
N
-
Y
---
T
L
F
L
---
V
G
-
L
F
I
I
A
A
G
L
G
C
L
----
E
T
A
A
N
P
F
V
T
V
L
----
G
P
E
S
S
G
H
F
R
--
L
----
N
L
-
A
Q
T
F
N
S
F
-
G
A
I
I
A
V
V
-------
F
G
Q
S
L
I
-----------
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
-
L
S
-
V
Q
T
P
Y
M
------
I
I
V
A
-------
I
V
L
L
V
A
L
L
-
I
M
L
T
K
F
-----
P
----
A
L
Q
S
D
N
H
-----
S
D
--
A
K
---
Q
G
S
-----
F
S
A
-----
S
L
S
R
L
A
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
Y
----------
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
E
I--
P
G
M
T
A
G
F
--------
A
A
-----
N
Y
L
T
G
T
M
-----
V
C
F
F
I
G
-
R
F
T
G
T
W
L
I
S
R
F
A
P
----------------------------------------------
H
K
V
L
A
A
-
Y
A
L
I
------
A
M
A
L
C
L
I
S
-----
A
F
-----
A
G
G
H
V
G
------
L
-
I
A
------
L
---------
T
L
C
S
A
F
M
S
-
I
Q
Y
-
P
T
I
F
S
----
L
---
G
I
K
N
----------
L
G
Q
D
T
K
-
Y
G
S
S
F
I
---
V
M
T
I
I
G
G
-
G
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
-
I
P
T
A
E
L
I
P
A
L
C
F
---
A
V
I
F
I
F
A
R
F
R
S
Q
T
----------------------------------------------------------------------------------------------------------------
5
Fugue
70.40
13%
-110
- C4 -
1PV6
-
LACY_ECOLI
A:
[1-417]
---
M
Y
Y
L
K
N
-------------------------------
T
N
F
W
M
F
G
L
F
F
F
F
Y
F
F
I
M
G
--------------
A
Y
F
P
F
--
F
P
I
W
---
L
H
D
-
I
-
N
-----
H
I
S
K
S
D
T
G
I
---------
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
---------------
F
G
L
L
S
D
K
-
L
G
L
R
K
Y
L
L
W
I
---
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
G
---
P
----
L
-
L
---
Q
Y
N
I
---
L
V
G
S
I
V
G
G
I
Y
L
G
F
C
----
F
N
A
G
A
P
A
V
E
A
F
----
I
E
-
K
V
S
R
R
S
NF
E
----
F
G
-
R
A
R
M
F
G
C
-
V
G
W
A
L
G
A
-------
S
I
V
G
I
M
-----------
F
--------------------------
T
-
I
N
-
N
Q
F
V
F
W
------
L
G
S
G
-------
C
A
L
I
L
A
V
L
-
L
F
F
-
A
K
-----
T
----
D
A
P
S
S
A
T
-----
V
A
--
N
A
---
V
G
A
NHSAF
S
L
K
-----
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
----------
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
----
F
F
A
T
G
E
Q
--------
G
T
-----
R
V
F
G
Y
V
T
-----
T
M
G
E
L
L
-
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
--------------------------------------------
G
G
K
N
A
L
-
L
L
A
G
------
T
I
M
S
V
R
I
I
-----
G
S
S
F
A
T
S
-----
A
----
L
E
V
V
I
L
------
K
---------
T
L
H
M
F
E
V
P
-
F
L
L
-
V
G
C
F
K
----
Y
---
I
T
S
Q
----------
F
E
V
R
F
S
A
T
I
Y
L
V
C
-
F
C
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
--
F
Q
G
A
Y
L
V
L
G
L
V
A
---
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
------
P
L
----------------------------------
S
L
L
R
R
Q
----
V
N
E
V
A
-----------------------------------------------------
15
HHSearch
67.89
14%
-120
- C4 -
3WDO
-
?
A:
[26-379]
-------------------------------------------------------------------------
M
F
M
V
--
L
P
V
L
-
T
T
Y
G
M
A
L
-
Q
-----
G
A
S
E
A
L
I
G
I
---------
A
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
---------------
F
G
L
L
S
D
R
-
I
G
R
K
P
L
I
V
G
G
---
L
A
V
F
A
A
G
S
V
I
A
A
L
---
S
---
D
----
S
-
I
---
W
G
I
I
---
L
G
-
R
A
L
Q
G
S
G
A
--
I
----
A
A
A
V
M
A
L
L
S
D
L
----
T
R
E
Q
N
R
T
K
A
--
M
----
A
F
-
I
G
V
S
F
G
I
-
T
F
A
I
A
M
V
-------
L
G
P
I
I
T
-----------
H
--------------------------
K
-
L
G
-
L
H
A
L
F
W
------
M
I
A
I
-------
L
A
T
T
G
I
A
L
-
T
I
W
-
V
V
-----
P
----
N
S
S
T
H
V
L
-----
N
R
---
E
---
S
G
M
-----
V
K
G
-----
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
----------
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
D
----
A
G
F
P
A
A
E
--------
H
W
K
V
Y
--
L
A
T
M
L
I
A
-----
F
G
S
V
V
P
-
F
I
I
Y
A
E
V
K
R
K
M
K
--
Q
----------------------------------------------
V
F
V
F
-
C
V
G
L
------
I
V
V
A
E
I
V
L
-----
W
N
A
----
Q
T
Q
F
W
Q
------
L
V
V
G
------
V
---------
Q
L
F
F
V
A
F
N
-
L
M
E
-
A
L
L
P
S
----
L
---
I
S
K
E
----------
S
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
-
T
S
Q
F
L
G
V
-
A
I
G
G
S
L
G
G
W
I
D
G
M
F
D
--
G
Q
G
V
F
L
A
G
A
M
L
A
---
A
V
W
L
A
V
A
S
T
M
K
E
P
P
Y
------
V
S
----------------------------------
S
L
R
I
E
I
----
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
E
E
E
H
S
A
--------------------------
17
HHSearch
66.92
14%
-111
* C4 *
2CFQ
-
LACY_ECOLI
A:
[21-394]
---------------------------------------------------------
F
--------------
I
M
G
A
Y
--
F
P
F
F
-
P
I
W
L
H
-
D
I
N
-----
H
I
S
K
S
D
T
G
I
---------
I
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
---------------
F
G
L
L
S
D
K
-
L
G
L
R
K
Y
L
L
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
I
F
---
G
---
P
----
L
-
L
Q
--
Y
N
I
L
---
V
G
-
S
I
V
G
G
I
Y
L
G
F
C
FNAG
A
P
A
V
E
A
F
I
E
K
V
----
S
--
R
R
S
N
F
E
--
F
----
G
R
-
A
R
M
F
G
C
V
-
G
W
A
L
G
A
S
-------
I
V
G
I
M
F
-----------
T
----------------------------
I
N
-
N
Q
F
V
F
W
------
L
G
S
G
-------
C
A
L
I
L
A
V
L
-
L
F
F
-
A
K
-----
T
----
D
A
P
S
S
A
T
-----
V
A
NA
V
G
AN
H
S
A
F
-----
S
L
K
-----
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
V
----------
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
FAT
G
E
Q
G
T
R
V
--------
F
G
-----
Y
V
T
T
M
G
E
-----
L
L
N
A
S
I
-
M
F
F
A
P
L
I
I
N
R
I
G
G
----------------------------------------------
K
N
A
L
L
L
-
A
G
T
I
------
M
S
V
R
I
I
G
S
-----
S
F
-----
A
T
S
A
L
E
------
V
V
I
L
------
K
---------
T
L
H
M
F
E
V
P
-
F
L
L
-
V
G
C
F
K
----
Y
---
I
T
S
Q
----------
F
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
-
F
F
K
Q
L
A
M
-
I
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
--
F
Q
G
A
Y
L
V
L
G
L
V
A
---
L
G
F
T
L
I
S
V
F
T
L
S
G
P
G
------
P
L
----------------------------------
S
L
L
R
R
Q
----
V
N
E
V
A
-----------------------------------------------------
11
Fugue
65.78
13%
-105
- C4 -
1GNL
2
HCP_DESDA
A:
[1-543]
SNA
M
F
C
Y
Q
C
Q
E
T
V
G
N
K
G
--
C
T
Q
V
G
V
C
G
K
K
P
E
T
A
A
L
Q
D
A
L
-
I
Y
V
T
K
G
L
G
Q
I
A
T
R
L
R
A
E
G
K
A
V
D
H
R
I
D
R
L
V
T
G
N
L
F
A
T
I
--
T
N
A
N
-
F
D
D
D
I
-
L
-
A
-----
E
R
V
R
M
T
C
A
A
---------
K
K
E
L
A
A
S
L
T
------DKSGLSDAALWEASE
K
S
A
M
L
A
K
-
A
G
T
V
G
V
M
A
T
T
---
D
D
D
V
R
S
L
R
W
L
I
T
F
---
G
---
L
----
K
-
G
---
M
A
A
Y
---
A
K
H
A
D
V
L
G
K
H
E
N
S
L
----
D
A
F
M
Q
E
A
L
A
K
T
L
DDS
L
S
-
V
A
D
L
V
A
--
L
----
T
L
-
E
T
G
K
F
G
V
-
S
A
M
A
L
L
D
-------
A
A
N
T
G
T
YGHP
E
I
T
K
V
N
I
G
--------------------------
V
-
G
S
-
N
P
G
I
L
I
S
G
HD
L
R
D
L
E
M
-------
L
L
K
Q
T
E
G
T
-
G
V
D
-
V
Y
-----
T
H
SEM
L
P
A
H
Y
Y
P
-----
A
F
--
K
K
---
Y
A
H
-----
F
K
G
-----
N
Y
G
N
A
W
W
K
Q
K
E
E
F
E
S
F
N
G
P
V
L
L
TTNCLVPPK
D
S
--
Y
K
D
R
V
Y
T
T
G
I
V
G
F
----
T
G
C
K
H
I
P
G
EIGEHKD
F
S
-----
A
I
I
A
H
A
K
T
CPAP
T
E
I
E
S
G
-
E
I
I
G
G
F
A
H
N
Q
V
L
A
L
A
--------------------------------------------
D
K
V
I
D
A
-
V
K
S
G
------
A
I
K
K
F
V
V
M
-----
A
G
C
D
G
R
A
K
S
R
S
Y
Y
----
T
D
F
A
E
G
LPKD
T
V
I
---------
L
T
A
G
C
A
K
Y
-
R
Y
N
-
K
L
N
L
G
----
D
IGG
I
P
R
V
----------
L
D
A
G
Q
C
N
D
S
Y
S
L
A
-
V
-
I
A
L
K
L
K
E
-
V
F
G
L
E
D
V
N
D
L
P
------
I
V
Y
N
I
A
W
Y
E
Q
K
A
---
V
I
V
L
L
A
L
L
S
L
G
V
K
N
I
------
H
L
----------------------------------
G
P
T
-
L
P
----
A
F
L
S
P
N
V
A
K
V
L
V
E
Q
F
N
I
G
G
I
T
S
P
Q
D
D
L
K
A
F
F
---------------------------
7
Fugue
56.14
13%
-122
- C1 -
3F6K
5
SORT_HUMAN
A:
[11-672]
---
R
V
R
D
F
V
A
K
L
A
N
N
T
H
Q
H
V
F
D
D
L
R
G
S
V
S
L
S
W
V
G
D
---
S
-
T
G
V
I
L
V
L
T
T
F
H
V
P
L
G
Q
S
K
--------------
L
Y
R
S
E
DY
G
K
N
F
-
K
D
I
T
D
-
L
-
I
-----
N
N
T
F
I
R
T
E
F
GMAIGPENS
G
K
V
V
L
T
A
E
V
S
G
G
S
R
G
---------------
G
R
I
F
R
S
S
D
F
A
K
N
F
V
Q
T
D
L
---
P
F
H
P
L
T
Q
M
M
Y
S
P
Q
---
N
---
S
----
D
-
Y
---
L
L
A
L
S
TE
N
G
L
W
V
S
K
N
F
G
G
K
W
E
----
E
I
H
K
A
V
C
L
A
K
W
----
G
S
-
D
N
T
I
F
F
--
T
T
Y
A
N
G
S
-
C
K
A
D
L
G
A
-
L
E
L
W
R
T
S
DLGKSFK
T
I
G
V
K
I
-----------
Y
--------------------------
S
-
F
G
-
L
G
G
R
F
L
------
F
A
S
V
M
A
D
KDT
T
R
R
I
H
V
S
T
D
Q
G
D
T
-
W
S
-----
M
----
A
Q
L
P
S
V
G
-----
Q
E
--
Q
F
---
Y
S
I
-----
L
A
A
NDD
M
-
V
F
M
H
V
D
E
P
G
D
T
G
F
G
T
I
F
T
S
D
D
----------
R
G
I
V
Y
S
K
S
L
D
R
H
L
Y
T
T
T
----
G
G
E
T
D
F
T
--------
N
V
TSLRG
V
Y
I
T
S
V
L
-----
S
E
D
N
S
I
-
Q
T
M
I
T
F
D
Q
G
G
R
W
T
H
L
RKPEN
S
E
C
D
ATAKNKN
E
C
S
L
H
I
H
A
S
Y
S
I
S
Q
KLNVPM
A
P
L
S
E
PNA
V
G
I
V
I
A
-
H
G
S
V
G
DAISV
M
V
P
D
V
Y
I
S
DDGGY
S
W
T
K
M
L
E
G
P
H
Y
Y
T
I
L
DS
G
G
I
I
V
A
------
I
E
H
S
SRPIN
V
I
K
F
S
T
D
E
G
Q
C
W
Q
-
T
Y
T
F
T
RDPI
Y
---
F
T
G
L
A
S
EPGARSM
N
I
S
I
W
G
F
T
E
S
F
L
T
S
-
Q
-
W
V
S
Y
T
I
D
-
F
K
D
I
L
E
R
N
C
E
E
K
D
Y
T
I
-
W
L
A
H
S
T
D
P
E
D
Y
E
DGC
I
L
G
Y
K
E
Q
F
L
R
L
R
K
S
S
------
M
C
QNGRDYVV
T
K
Q
P
S
I
C
L
C
SLEDFLCDFG
Y
Y
R
P
END
S
K
C
V
E
Q
----
P
E
L
K
G
H
D
L
E
F
C
L
Y
G
R
E
E
H
L
T
T
N
G
Y
R
K
I
P
G
D
K
C
Q
G
GVNPVR
E
V
K
D
L
K
K
K
C
T
S
NFLSPEK
18
HHSearch
52.16
17%
-119
- C4 -
3WDO
-
?
A:
[11-176]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
W
G
L
G
T
V
F
S
L
R
----------
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L---
Q
G
A
S
E
A
L
--------
I
G
-----
I
A
I
G
I
Y
G
-----
L
T
Q
A
V
F
-
Q
I
P
F
G
L
L
S
D
R
I
G
--
R
--------------------------------------------
K
P
L
I
V
G
-
G
L
A
V
------
F
A
A
G
S
V
I
A
-----
A
L
-----
S
D
S
I
W
G
------
I
I
L
G
------
R
---------
A
L
Q
G
S
G
---
A
I
A
-
A
A
V
M
A
----
L
---
L
S
D
L
----------
T
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
-
V
S
F
G
I
T
F
-
A
I
A
M
V
L
G
P
I
I
T
H
K
L
G
--
L
H
A
L
F
W
M
I
A
I
L
A
---
T
T
G
I
A
L
T
I
W
V
V
P
N
S
S
------
T
H
----------------------------------
V
L
N
R
E
S
----
G
M
V
K
G
S
F
S
K
V
L
A
E
P
R
L
L
K
L
N
F
G
I
M
C
L
H
M
L
L
M
S
--------------------------
22
HHSearch
51.47
15%
-122
- C4 -
2CFQ
-
LACY_ECOLI
A:
[257-395]
----------------------------------------------------------------------------------------------------
G
T
R
V
F
G
Y
---------
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
---------------
A
P
L
I
I
N
R
-
I
G
G
K
N
A
L
L
L
A
---
G
T
I
M
S
V
R
I
I
G
S
S
F
---
A
---
T
----
S
-
A
---
L
E
V
V
---
I
L
K
-
T
L
H
M
F
E
V
P
F
L
----
L
V
G
C
F
K
Y
I
T
S
Q
----
F
E
V
R
F
S
A
T
I
--
Y
----
L
V
C
F
C
F
F
K
Q
L
-
A
M
I
F
M
S
V
-------
L
A
G
N
M
Y
-----------
E
--------------------------
S
-
I
G
-
F
Q
G
A
Y
L
------
V
L
G
L
-------
V
A
L
G
F
T
L
I
-
S
V
F
-
T
L
-----
S
----
G
P
G
P
L
S
L
-----
L
R
--
R
Q
---
V
N
E
-----
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
48.35
29%
-99
- C4 -
2GFP
-
EMRD_ECOLI
A:
[66-219]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
R
-
V
G
R
R
P
V
I
L
V
G
---
M
S
I
F
M
L
A
T
L
V
A
V
T
---
T
---
S
----
S
-
L
---
T
V
L
I
---
A
A
S
A
M
Q
G
M
G
--
T
G
V
----
G
G
V
M
A
R
T
L
P
R
D
----
L
Y
-
E
R
T
Q
L
R
--
H
----
A
N
-
S
L
L
N
M
G
I
L
V
S
P
L
L
A
P
-------
L
I
G
G
L
L
-----------
D
--------------------------
T
M
W
N
-
W
R
A
C
Y
L
------
F
L
L
V
-------
L
C
A
G
V
T
F
S
-
M
A
R
-
W
M
-----
P
----
E
T
R
P
V
D
----------
A
P
---
R
T
R
-----
L
L
T
-----
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
--
M
L
I
----------
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
----
G
A
V
L
G
L
S
--------
S
M
-----
T
V
S
I
L
F
I
-----
L
P
I
P
A
A
-
F
F
G
A
W
F
A
G
R
P
N
K
R
F
S
--------------------------------------------
T
L
M
W
Q
S
-
V
I
C
C
------
L
L
A
G
L
L
M
W
-----
I
P
D
W
F
G
V
M
N
V
W
T
L
----
L
V
P
A
A
L
------
F
---------
F
F
G
A
G
M
L
F
-
P
L
A
-
T
S
G
A
M
----
E
---
P
F
P
F
----------
L
A
G
T
A
G
A
L
V
G
G
L
Q
-
N
-
I
G
S
G
V
L
A
-
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
-
L
M
T
L
M
G
L
L
I
V
L
C
---
W
L
P
L
-------------------------------------------------------------------------------------------------------------------------
20
HHSearch
46.58
18%
-98
- C4 -
2GFP
-
EMRD_ECOLI
A:
[22-173]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
----
L
N
V
R
E
G
A
--------
V
Q
-----
S
V
M
G
A
Y
L
-----
L
T
Y
G
V
S
-
Q
L
F
Y
G
P
I
S
D
R
V
G
--
R
--------------------------------------------
R
P
V
I
L
V
-
G
M
S
I
------
F
M
L
A
T
L
V
A
-----
V
T
-----
T
S
S
L
T
V
------
L
I
A
A
------
S
---------
A
M
Q
G
M
G
T
G
-
V
G
G
-
V
M
A
R
T
----
L
---
P
R
D
L
----------
Y
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
-
M
G
I
L
V
S
P
-
L
L
A
P
L
I
G
G
L
L
D
T
M
W
N
--
W
R
A
C
Y
L
F
L
L
V
L
C
---
A
G
V
T
F
S
M
A
R
W
M
P
E
T
R
------
P
V
----------------------------------
D
A
P
R
T
R
----
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
--------------------------
19
HHSearch
40.95
12%
-94
- C4 -
1PW4
-
GLPT_ECOLI
A:
[54-199]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
E
----
Q
G
F
S
R
G
D
--------
L
G
-----
F
A
L
S
G
I
S
-----
I
A
Y
G
F
S
-
K
F
I
M
G
S
V
S
D
R
S
N
--
P
--------------------------------------------
R
V
F
L
P
A
-
G
L
I
L
------
A
A
A
V
M
L
F
M
-----
G
F
V
P
W
A
-
T
S
S
I
A
V
------
M
F
V
L
------
L
---------
F
L
C
G
W
F
Q
G
-
M
G
W
-
P
P
C
G
R
----
T
---
M
V
H
W
----------
W
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
-
C
A
H
N
V
G
G
-
G
I
P
P
L
L
F
L
L
G
M
A
W
F
N
D
-
W
H
A
A
L
Y
M
P
A
F
C
A
---
I
L
V
A
L
F
A
F
A
M
M
R
D
T
P
------
Q
S
----------------------------------
C
G
L
P
P
I
----
E
E
Y
K
N
D
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
V
--------------------------
21
HHSearch
40.74
13%
-95
- C4 -
3O7Q
1
FUCP_ECOLI
A:
[37-177]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
----------
A
V
A
N
N
L
N
D
I
L
L
P
Q
F
Q
Q
A
----
F
T
L
T
N
F
Q
--------
A
G
-----
L
I
Q
S
A
F
Y
-----
F
G
Y
F
I
I
-
P
I
P
A
G
I
L
M
K
K
L
S
--
Y
--------------------------------------------
K
A
G
I
I
T
-
G
L
F
L
------
Y
A
L
G
A
A
L
F
-----
W
P
A
A
E
--
I
M
N
Y
T
L
------
F
L
V
G
------
L
---------
F
I
I
A
A
G
L
G
-
C
L
E
-
T
A
A
N
P
----
F
---
V
T
V
L
----------
G
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
-
T
F
N
S
F
G
A
-
I
I
A
V
V
F
G
Q
S
L
I
L
S
N
V
P
-
H
Q
S
Q
D
V
L
D
K
M
S
P
---
E
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
------
T
P
----------------------------------
Y
M
I
I
V
A
----
I
V
L
L
V
A
L
L
I
M
L
T
K
F
P
A
L
Q
S
D
N
H
S
D
A
K
Q
G
S
F
S
A
--------------------------
1
PsiBlast_PDB
28.80
27%
-84
- C3 -
2O8F
-
MSH2_HUMAN
A:
[313-397]
--------------------------------------------------------------------------------------------
F
-----
Q
G
---
D
T
T
G
---------
S
Q
S
L
A
A
L
L
N
K
C
K
T
P
Q
---------------
G
Q
R
L
V
N
Q
-
W
I
K
Q
P
L
M
D
K
N
---
R
I
E
E
R
L
N
L
V
-
E
A
F
---
V
---
E
----
D
A
E
---
L
R
Q
T
---
L
Q
E
D
L
L
R
R
F
-----------
P
D
L
N
R
L
A
K
K
----
F
Q
-
R
Q
A
A
N
L
--
Q
----
D
C
-
Y
R
L
Y
Q
G
I
-
N
Q
L
P
N
V
I
-------
Q
A
L
E
K
H
-----------
E
--------------------------
G
-
K
H
-
Q
K
L
L
L
A
------
V
F
V
T
-------
P
L
T
D
L
R
S
D
-
F
S
K
-
F
Q
-----
E
----
M
I
E
T
T
L
D
-----
M
D
--
Q
V
---
E
N
H
-----
E
F
L
-----
V
K
P
S
F
D
P
N
L
S
E
L
R
E
I
M
N
D
L
E
K
----------
K
M
Q
S
T
L
I
S
A
A
R
D
L
G
L
D
P
----
G
K
Q
I
K
L
D
--------
S
S
-----
A
Q
F
G
Y
Y
F
-----
R
V
T
C
K
E
-
E
K
V
L
R
N
N
K
N
F
S
T
V
D
I
--------------------------------------------
Q
K
N
G
V
K
-
F
T
N
S
------
K
L
T
S
L
N
E
E
-----
Y
T
K
N
K
T
E
Y
E
E
A
Q
D
----
A
I
V
K
E
I
------
V
---------
N
I
S
S
G
Y
V
E
-
P
M
Q
-
T
L
N
D
V
----
L
---
A
Q
L
D
----------
A
V
V
S
F
A
H
V
S
N
G
A
P
-
V
-
P
Y
V
R
P
A
I
-
L
E
K
G
Q
G
R
I
I
L
K
A
S
R
H
A
-
C
V
E
V
Q
D
E
I
A
F
I
P
---
N
D
V
Y
F
E
K
D
K
Q
M
F
H
I
I
------
T
G
----------------------------------
P
N
M
G
G
K
----
S
T
Y
I
R
Q
T
G
V
I
V
L
M
A
Q
I
G
C
F
V
P
C
E
S
A
E
V
S
I
V
D
C
--------------------------