@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NCKX5_HUMAN: (2015-12-08 )
MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG
Atome Classification :
(20 SA)
.........10......-----..20........30........40........50----.........60........70........80...---.---..--..90-----------------------------....-.....100.......110....-----...120.------......130.......140--..---.....150.--.---...-..160......-------------.170.--------------......180.....---.--.190--.....-----...200.......210......--.220.......230.......240........250.......260....----...270.......280.......290.-......300.......310.......320...-....330..-------...---..340.......-----350.--------...---...---360....-...370......----.380.......390.....-..400..----.....410...-------.....420.......430---.......440.......450------.......460......--------------------.470.......480.....------..490..---------------.....500---------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQTKG
G
Q
T
W
A
R
R
A
L
L
L
G
-----
I
L
W
A
T
AHLPLSGTS
L
P
Q
RLPRATGNS
T
Q
C
V
ISP-----SSEF
P
E
G
F
F
T
R
Q
E
RRDG
G
I
I
I
Y
F
L
I
I
V
Y
M
F
M
A
I
S
---
I
---
V
C
--
D
E
Y------------------------------FL
P
S
-
L
E
I
I
S
E
S
LGLSQDVAG
T
T
F
MAA-----GSS
A
P
E
L
------
V
T
A
F
L
G
V
FITKGD
I
G
I
S
T
I
--
L
G
---
S
A
I
Y
N
L
L
G
I
--
C
---
A
A
C
-
G
L
L
S
N
T
V
S
TL
S
-------------
C
W
P
L
F
--------------
R
D
C
A
A
Y
T
I
S
A
A
A
V
L
---
G
--
I
I
Y---DN
Q
V
Y
-----WYE
G
A
L
L
L
L
I
Y
G
L
Y
V
L
V
L
CFDI--KI
N
Q
Y
I
I
K
KC
S
P
C
C
A
C
L
A
K
A
M
E
R
-SEQQPLMGWEDEGQ
P
F
I
R
RQSRTDS----
G
I
F
YEDSGY
S
Q
L
S
I
S
L
HG
L
S
Q
VSEDPP-SVFNM
P
E
A
D
L
K
R
I
F
W
V
L
S
L
P
I
I
T
L
L
FLTT
P
D
C
-
R
K
K
F
W
K
N
Y
F
-------
V
I
T
---
F
F
M
S
A
I
W
I
S
A
F
T
-----
Y
I
L
V
--------
W
M
V
---
T
IT---GETLEI
P
-
D
T
V
M
G
L
T
L
LAAG----TS
I
P
D
T
I
A
S
V
L
V
ARKGKG
D
-
M
A
M
S
N
I
V----G
S
N
V
F
D
M
-
L
C
L-------G
I
P
W
F
I
K
T
A
FINGSAPAE---VNSR
G
L
T
Y
I
T
I
S
L
N
I
S
I
I
F
L
------
F
L
A
VHFN
G
W
K
L
D
R
K
L
G
--------------------
I
V
C
L
L
S
Y
L
G
L
A
T
L
S
V
L
Y
E
L------GIIGNNK---------------IRGCGG-----------------------------------------
33
Fugue
75.74
20%
-127
- C4 -
4UZ1
1
NOTUM_HUMAN
A:
[9-375]
----------
N
E
D
L
R
L
H
-----
L
L
L
N
T
--------------------
S
V
T
C
---------
N
D
G
S
P
A
G
Y
Y
L
K
E
S
R
G
S
R
R
W
L
L
F
L
E
G
G
W
Y
C
F
N
--
R
---
E
---
N
C
--
D
S
R
------------------------------
Y
D
T
M
-
R
R
L
M
S
-
S
R
D
W
P
R
T
R
T
G
T
G
I
L
--------
S
S
Q
P
E
E
------
N
P
Y
W
W
N
A
-----------------------
N
M
V
F
I
P
Y
C
---
S
S
D
-
V
W
S
G
A
S
S
K
S
E
K
-------------
N
E
Y
A
F
---------------------
M
G
A
L
I
I
Q
---
E
--
V
V
R
---
E
L
L
G
R
-----
G
L
S
G
A
K
V
L
L
L
A
G
S
---------------------
S
A
G
G
T
G
V
L
L
N
V
D
R
-
V
A
E
Q
----
L
E
K
L
G
Y
P
A
I
Q
V
R
G
L
A
D
S
----
G
W
F
L
D
N
K
Q
Y
R
H
-----------
T
D
C
V
D
-
T
I
T
C
A
P
T
E
A
I
R
R
G
I
R
Y
W
N
G
V
V
-------
P
E
R
C
-
R
R
Q
F
Q
E
G
E
E
-------
W
N
C
---
F
F
G
Y
K
V
Y
P
T
L
R
S
-----
P
V
F
V
V
Q
------
W
L
F
D
E
A
Q
L
T
---
V
D
N
V
H
L
P
V
Q
E
G
L
R
L
Y
I
Q
N
L
G
----
R
E
L
R
H
T
L
K
D
V
P
A
----------------------
S
F
A
P
-
A
C
L
-------
S
H
E
I
I
I
R
S
H
W
T
D
V
Q
V
K
G
T
---
S
L
P
R
A
L
H
C
W
D
R
S
L
H
K
T
P
L
-----------
K
G
C
P
V
H
L
V
D
S
C
P
W
--------------------
P
H
C
N
P
S
--------------------------------------------
C
P
T
G----------------------------------------
31
Fugue
75.00
17%
-92
- C4 -
4CZB
-
NAH1_METJA
A:
[1-415]
M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
-----
S
L
V
A
K
I
A
E
K
L
K
I
P
D
I
P
L
L
L
L
L
G
L
I
I
G
P
F
L
Q
I
I
P
-----
S
D
S
A
M
E
I
F
-----
E
Y
A
G
P
I
G
L
I
F
I
L
L
G
G
A
F
T
M
R
I
---
S
---
L
L
--
K
R
V
------------------------------
I
K
T
V
-
V
R
L
D
T
I
T
F
L
I
T
L
L
I
S
G
F
I
F
N
M
V
L
----
N
L
P
Y
T
S
P
------
V
G
Y
L
F
G
A
I
T
A
A
T
D
P
A
---------------
T
L
I
P
V
--
F
---
S
R
V
-
R
T
N
P
E
V
A
I
T
L
E
-------------
A
E
S
I
F
--------------
N
D
P
L
G
I
-
V
S
T
S
V
I
L
---
G
--
L
-
F
---
G
L
F
S
S
-----
S
N
P
L
I
D
L
I
T
L
A
G
G
A
I
V
V
G
L
L
L
A
--
K
I
Y
E
K
I
I
I
H
C
D
-----
F
H
E
Y
V
A
P
-
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
D
L
L
P
S
I
C
G
----------
Y
G
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
D
-
D
I
---
D
Y
K
Y
I
V
S
F
C
D
D
L
S
L
L
A
R
V
F
I
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
Y
F
-------
I
P
G
---
L
L
V
A
L
G
S
I
F
L
A
R
-----
P
L
G
V
--------
F
L
G
------------------------
L
I
G
S
K
----
H
S
F
K
E
K
L
Y
F
A
L
E
G
P
R
G
V
V
P
-
A
A
L
A
V
T
V
----
G
I
E
I
L
K
--------------------------
N
A
D
K
---
I
P
A
S
I
T
K
Y
I
T
---------------------------
P
T
D
I
A
--------------------
G
T
I
I
I
G
T
F
M
T
I
L
L
S
V
I
L
E
A
------
S
W
A
G
M
L
A
---------------
L
K
L
L
G
E
-----------------------------------------
29
Fugue
74.26
17%
-98
- C4 -
4IKW
13
?
A:
[3-494]
--
S
I
D
K
Q
Q
I
A
A
------------------------
S
V
P
Q
R
----------
G
F
F
G
H
-----
P
K
G
L
F
T
L
F
F
T
E
F
W
E
R
F
S
Y
Y
G
M
R
A
I
L
V
Y
Y
M
Y
Y
E
V
S
KGG
L
---
G
L
--
D
E
H
------------------------------
L
A
L
A
-
I
M
S
I
Y
G
A
L
V
Y
M
S
G
I
I
G
G
-
W
L
A
D
-----
R
V
F
G
T
S
R
------
A
V
F
Y
G
G
L
L
I
M
A
G
H
I
A
L
A
I
P
GG
V
A
---
A
L
F
V
S
M
A
L
I
--
V
---
L
G
T
-
G
L
L
K
P
N
V
S
S
I
V
G
D
M
Y
KPGDDR
R
D
A
G
F
S
I
F
--------------
Y
M
G
I
N
L
G
-
A
F
L
A
P
L
---
V
--
V
G
T
---
A
G
M
K
Y
-----
N
F
H
L
G
F
G
L
A
A
V
G
M
F
L
G
L
V
V
F
V
A
--
T
R
K
K
N
L
-
G
L
A
G
T
Y
V
P
N
P
L
T
P
A
E
K
-
K
K
A
A
A
I
M
A
V
G
A
V
V
I
A
V
L
L
A
I
L
I
P
N
G
WFT
V
E
T
F
I
S
L
V
G
I
L
G
I
I
I
P
I
I
Y
F
V
V
M
Y
R
S
P
K
-
T
----
T
A
E
E
R
S
R
V
I
A
Y
I
P
L
F
V
A
S
A
M
F
W
A
I
Q
E
Q
-
G
S
T
I
L
A
N
Y
A
D
KRTQLD
V
A
G
---
I
H
L
S
P
A
W
F
Q
S
L
N
-----
P
L
F
I
I
I
L
A
P
V
F
A
W
M
W
---
V
K
L
---
G
K
R
Q
P
T
I
-
P
Q
K
F
A
L
G
L
L
F
A
G
----
L
S
F
I
V
I
L
V
P
G
H
L
S
G
G
G
L
V
H
P
I
W
L
V
L
S
Y
----
F
I
V
V
L
G
E
-
L
C
L
-------
S
P
V
G
L
S
A
T
T
K
L
---
A
P
A
A
---
F
S
A
Q
T
M
S
L
W
F
L
S
N
A
A
A
Q
A
I
N
------
A
Q
L
V
R
F
Y
T
P
E
-----
N
--------------------
E
T
A
Y
F
G
T
I
G
G
A
A
L
V
L
G
L
I
L
------
L
A
I
A
P
R
I
---------------
G
R
L
M
K
G
-----------------------------------------
16
HHSearch
70.79
20%
-130
* C5 *
3V5U
13
Y091_METJA
A:
[4-304]
--------------------------------------------------------------------------------
L
G
V
G
Y
F
L
L
G
L
I
L
L
----
Y
---
Y
G
--
S
D
W
------------------------------
F
V
L
G
-
S
E
R
I
A
R
H
F
N
V
S
N
F
V
I
G
A
T
V
M
A
I
-----
G
T
S
L
P
E
I
------
L
T
S
A
Y
A
S
Y
M
H
A
P
G
I
S
I
G
N
A
--
I
G
---
S
C
I
C
N
I
G
L
V
--
L
---
G
L
S
-
A
I
I
S
P
--
I
I
V
D
-------------
K
-
N
L
Q
--------------
K
N
I
L
V
Y
L
L
F
V
I
F
A
A
------
V
I
G
---
I
D
G
F
S
-----
W
I
D
G
V
V
L
L
I
L
F
I
I
Y
L
R
W
T
V
K
N
G
--
S
A
---------------------------------------------------------------------------
K
-----
N
N
----
P
----------------------------
S
V
V
F
S
-------
L
V
L
---
L
I
I
G
L
I
G
V
L
V
G
A
-----
E
L
F
V
--------
D
G
A
---
K
K
I
---
A
L
A
L
D
I
S
-
D
K
V
I
G
F
T
L
V
A
F
G
----
T
S
L
P
E
L
M
V
S
L
A
A
A
K
R
N
L
G
G
-
M
V
L
G
N
V
I
----
G
S
N
I
A
D
I
G
G
A
L
-------
A
V
G
S
L
F
M
H
L
P
-----------
A
E
N
V
Q
---
M
A
V
L
V
I
M
S
L
L
L
---------
Y
L
F
A
K
Y
S
K
I
G
R
W
Q
G
--------------------
I
L
F
L
A
L
Y
I
I
A
I
A
S
L
R
M
G
G
G
---------------------------------------------------------------------------
30
Fugue
69.22
15%
-115
- C5 -
4K1C
6
VCX1_YEAST
A:
[27-406]
------
T
A
W
R
A
A
V
Y
D
L
Q
-----
Y
I
L
K
A
S
P
L
N
F
L
L
V
F
V
P
L
G
L
I
W
G
H
F
Q
L
S
-------------------------
H
T
L
T
F
L
F
N
F
L
A
I
I
P
L
A
A
I
L
A
---
N
---
A
T
--
E
E
L
------------------------------
A
D
K
A
------------
G
N
T
I
G
G
L
L
N
A
T
-----
F
G
N
A
V
E
L
------
I
V
S
I
I
A
L
K
K
G
Q
V
R
I
V
Q
A
S
M
--
L
G
---
S
L
L
S
N
L
L
L
V
--
L
---
G
L
C
-
F
I
F
G
G
Y
N
R
V
---------------------------------------------------
Q
--
Q
T
F
---
N
Q
T
A
A
-----
Q
T
M
S
S
L
L
A
I
A
C
A
S
L
L
I
P
A
A
F
R
A
--
T
L
P
F
I
------------
D
G
K
I
L
E
-
L
S
R
G
T
S
I
V
I
L
I
V
Y
V
L
F
L
Y
F
Q
L
G
S
H
H
----
A
L
F
E
Q
Q
E
E
E
T
D
E
V
M
S
T
I
S
-----
R
N
P
H
-
H
S
L
S
----------------------------------
V
K
S
S
-------
L
V
I
---
L
L
G
T
T
V
I
I
S
F
C
A
-----
D
F
L
V
--------
G
T
I
---
D
N
V
---
V
E
S
T
G
L
S
-
K
T
F
I
G
L
I
V
I
P
I
V
----
G
N
A
A
E
H
V
T
S
V
L
V
A
M
K
D
K
M
D
-
L
A
L
G
V
A
I
----
G
S
-
S
L
Q
V
-
A
L
F
-------
V
T
P
F
M
V
L
V
G
W
M
I
D
V
---
P
---
M
T
L
N
F
S
T
F
E
T
A
T
L
F
I
A
V
F
L
S
------
N
Y
L
I
L
D
G
--
E
S
N
W
L
E
G
--------------------
V
M
S
L
A
M
Y
I
L
I
A
M
A
F
F
Y
Y
P
D
------
E
--------------------------------------------------------------------
26
Fugue
67.51
19%
-132
- C5 -
3V5U
13
Y091_METJA
A:
[1-304]
------------------------------------------------------------------------------
M
V
I
L
G
V
G
Y
F
L
L
G
L
I
L
L
---
Y
---
Y
G
--
S
D
W
------------------------------
F
V
L
G
-
S
E
R
I
A
R
H
F
N
V
S
N
F
V
I
G
A
T
V
M
A
I
-----
G
T
S
L
P
E
I
------
L
T
S
A
Y
A
S
Y
M
H
A
P
G
I
S
I
G
N
A
--
I
G
---
S
C
I
C
N
I
G
L
V
--
L
---
G
L
S
-
A
I
I
S
P
----
I
I
-------------
V
D
K
N
L
--------------
Q
K
N
I
L
V
Y
L
L
F
V
I
F
A
---
A
--
V
I
G
---
I
D
G
F
S
-----
W
I
D
G
V
V
L
L
I
L
F
I
I
Y
L
R
W
T
V
K
N
G
--
S
A
K
N
--------------------------------------------------------------------------------------------------------------
N
P
S
V
V
F
S
L
V
-------
L
L
I
---
I
G
L
I
G
V
L
V
G
A
-------
E
L
F
V
--------
D
G
A
---
K
K
I
---
A
L
A
L
D
I
S
-
D
K
V
I
G
F
T
L
V
A
F
G
----
T
S
L
P
E
L
M
V
S
L
A
A
A
K
R
N
L
G
G
-
M
V
L
G
N
V
I
----
G
S
N
I
A
D
I
-
G
-----------------
G
A
L
A
V
G
S
L
F
M
---
H
L
P
A
E
N
V
Q
M
A
V
L
V
I
M
S
L
L
L
Y
------
L
F
A
K
Y
S
---
K
I
G
R
W
Q
G
--------------------
I
L
F
L
A
L
Y
I
I
A
I
A
S
L
R
M
G
G
G
---------------------------------------------------------------------------
34
Fugue
65.34
16%
-110
- C4 -
3W5F
6
?
A:
[3-708]
-
E
A
E
F
S
V
S
Y
D
D
R
A
I
I
I
N
GKRKI
L
I
S
G
S
I
H
Y
P
R
S
T
P
Q
M
W
P
D
L
I
Q
K
A
K
D
G
G
L
D
V
I
E
T
Y
V
F
W
N
G
H
E
P
S
P
G
K
Y
N
F
E
G
R
Y
D
L
V
R
F
I
K
M
V
Q
R
A
G
L
Y
V
N
L
R
---
I
GPY
V
C
--
A
E
W
NFGGFP
V
W
L
K
Y
VPGMEFRTNN
Q
P
F
K
V
A
M
Q
G
F
V
Q
K
-
I
V
N
M
M
K
S
E
N
L
F
E
S
Q
G
G
P
I
I
M
A
Q
I
E
NEY
G
P
V
E
W
E
I
G
A
P
G
K
A
Y
T
K
W
A
A
Q
M
A
V
G
L
K
T
G
V
P
W
I
--
M
C
KQE
D
A
P
D
P
V
I
D
T
--
C
N
G
-
F
Y
C
E
G
F
R
P
N
K
P
Y
K
P
K
-------------
M
W
T
E
V
WT
G
W
Y
T
K
FGG
P
I
P
Q
R
P
A
E
D
I
A
F
S
V
A
R
F
V
Q
N
N
G
--
S
F
F
---
N
Y
Y
M
Y
HGGTN
F
G
R
T
S
S
G
L
F
I
A
T
S
Y
D
Y
D
A
P
L
D
E
YG
L
L
N
E
P
K
Y
G
H
L
R
D
L
H
K
A
I
K
L
S
E
P
A
L
V
S
S
Y
A
A
V
T
S
L
G
S
N
Q
E
A
H
V
Y
R
S
K
S
G
A
----
C
A
A
F
L
S
N
Y
D
S
R
Y
S
V
K
V
T
F
Q
N
R
P
Y
N
L
P
P
W
S
I
S
I
L
P
D
C
K
-
T
A
V
Y
N
T
A
Q
V
N
S
Q
S
S
S
I
K
M
T
P
A
G
-
G
G
L
S
W
Q
S
Y
N
-------
E
E
T
P
T
A
L
T
A
N
G
L
W
E
Q
K
N
V
TRDSS
D
Y
L
W
--------
Y
M
T
---
N
V
N
I
A
S
N
E
G
F
L
K
N
-
G
K
D
P
Y
L
T
V
M
S
A
G
H
V
L
H
V
F
V
N
G
K
L
S
G
T
V
Y
G
T
L
D
N
P
K
-
L
T
Y
S
G
N
V
K
L
R
A
G
I
N
K
I
S
L
-
L
S
V
S
VGLPNV
G
V
H
Y
D
T
W
N
A
G
V
L
G
P
V
T
L
S
GLN
E
G
S
R
N
L
A
K
Q
K
W
S
Y
K
V
G
L
K
G
E
S
L
SLHS
L
S
G
S
S
S
V
E
W
V
R
G
S
L
M
A
QKQPL
T
W
Y
K
A
T
F
N
APGGN
D
P
L
A
L
D
M
A
S
M
G
K
G
Q
I
W
I
N
G
E
G
VGRHWP
G
Y
I
A
Q
G
D
C
S
KCSYAGTFNEKKC
Q
T
N
C
G
Q
PSQR
W
Y
H
V
P
RSWLKPSG
N
L
L
V
V
F
E
EWGGNPTG
I
S
L
V
R
R
S
R
S
5
PsiBlast_PDB
49.34
25%
-69
- C5 -
4KJS
-
CHAA_BACSU
A:
[208-341]
--------------------------------------------------------------------------------------
I
V
L
F
A
A
T
I
---
V
---
V
A
Y
I
S
E
N
------------------------------
L
V
H
T
-
F
H
S
V
A
E
Q
F
G
W
S
E
L
F
I
G
V
I
I
V
A
I
-----
V
G
N
A
A
E
H
------
A
S
A
I
I
M
A
F
K
N
K
M
D
I
A
V
E
I
A
--
V
G
---
S
T
L
Q
--
I
A
M
--
F
---
V
A
P
-
V
L
V
I
C
S
I
F
F
P
T
-------------
S
M
P
L
V
--------------
F
T
L
P
E
L
V
A
M
V
S
A
V
L
---
L
--
M
I
A
I
S
N
D
G
D
S
N
-----
W
F
E
G
A
T
L
L
A
A
Y
V
I
M
A
I
G
F
F
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
47.25
20%
-77
- C5 -
3V5U
10
Y091_METJA
A:
[162-304]
-------------------------------------------------------------------------------
V
F
S
L
V
L
L
I
I
G
L
I
G
V
----
L
---
V
G
--
A
E
L
------------------------------
F
V
D
G
-
A
K
K
I
A
L
A
L
D
I
S
D
K
V
I
G
F
T
L
V
A
F
-----
G
T
S
L
P
E
L
------
M
V
S
L
A
A
A
K
R
N
L
G
G
M
V
L
G
N
V
--
I
G
---
S
N
I
A
D
I
G
G
A
--
L
---
A
V
G
-
S
L
F
M
H
--
L
P
A
E
---------------
N
----------------
V
Q
M
A
V
L
V
I
M
S
L
L
L
Y
---
L
--
F
A
K
---
Y
S
K
I
G
-----
R
W
Q
G
I
L
F
L
A
L
Y
I
I
A
I
A
S
L
R
M
G
G
--
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
47.00
25%
-57
- C5 -
4KJR
-
CHAA_BACSU
A:
[208-341]
--------------------------------------------------------------------------------------
I
V
L
F
A
A
T
I
---
V
---
V
A
Y
I
S
E
N
------------------------------
L
V
H
T
-
F
H
S
V
A
E
Q
F
G
W
S
E
L
F
I
G
V
I
I
V
A
I
-----
V
G
N
A
A
E
H
------
A
S
A
I
I
M
A
F
K
N
K
M
D
I
A
V
E
I
A
--
V
G
---
S
T
L
Q
--
I
A
M
--
F
---
V
A
P
-
V
L
V
I
C
S
I
F
F
P
T
-------------
S
M
P
L
V
--------------
F
T
L
P
E
L
V
A
M
V
S
A
V
L
L
M
I
A
--
I
S
N
---
D
G
D
S
N
-----
W
F
E
G
A
T
L
L
A
A
Y
V
I
M
A
I
G
F
F
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
39.76
24%
-70
- C5 -
4K1C
3
VCX1_YEAST
A:
[272-393]
------------------------------------------------------------------------------------------------------
C
--
A
D
F
------------------------------
L
V
G
T
-
I
D
N
V
V
E
S
T
G
L
S
K
T
F
I
G
L
I
V
I
P
I
-----
V
G
N
A
A
E
H
------
V
T
S
V
L
V
A
M
K
D
K
M
D
L
A
L
G
V
A
--
I
G
---
S
S
L
Q
V
A
L
F
V
--
T
P
F
M
V
L
V
-
G
W
M
I
D
V
P
M
T
L
N
-----------------
F
--------------
S
T
F
E
T
A
T
L
F
I
A
V
F
L
---
S
N
Y
L
I
L
---
D
G
E
S
N
-----
W
L
E
G
V
M
S
L
A
M
Y
I
L
I
A
M
A
F
F
Y
Y
P
--
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
31.98
42%
69
- C5 -
3V5S
-
Y091_METJA
A:
[192-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
D
I
S
-
D
K
V
I
G
F
T
L
V
A
F
G
----
T
S
L
P
E
L
M
V
S
L
A
A
A
K
R
N
L
G
G
-
M
V
L
G
N
V
I
----
G
S
N
I
A
D
I
-
G
G
A
-------
L
A
V
G
S
L
F
M
H
L
P
A
E
N
V
Q
M
A
---
V
L
V
I
M
S
L
L
L
Y
L
F
A
K
Y
S
K
I
G
R
------
W
Q
G
I
L
F
L
A
L
Y
I
I
A
I
A
S
--------------------
L
R
M
-------------------------------------------------------------------------------------------
20
HHSearch
31.84
38%
1560
- C2 -
2K0Q
-
COPK_CUPMC
A:
[44-51]
M
E
T
R
D
G
T
K
I
I
M
K
G
N
E
I
F
-----
R
L
D
E
A
L
R
K
G
H
S
E
G
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
31.28
42%
77
- C5 -
3V5U
4
Y091_METJA
A:
[192-241]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
D
I
S
-
D
K
V
I
G
F
T
L
V
A
F
G
----
T
S
L
P
E
L
M
V
S
L
A
A
A
K
R
N
L
G
G
-
M
V
L
G
N
V
I
----
G
S
N
I
A
D
I
-
G
G
A
-------
L
A
V
G
S
L
F
M
H
L
P
A
E
N
V
Q
M
A
---
V
L
V
I
M
S
L
L
L
Y
L
F
A
K
Y
S
K
I
G
R
------
W
Q
G
I
L
F
L
A
L
Y
I
I
A
I
A
S
--------------------
L
R
M
G
G
G
----------------------------------------------------------------------------------------
12
PsiBlast_PDB
26.29
40%
107
- C6 -
3P4P
1
FRDB_ECOLI
B:
[59-83]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
I
--
C
---
G
S
C
-
G
M
M
V
N
N
V
P
K
L
A
-------------
C
K
T
F
L
--------------
R
D
Y
T
D
G
M
K
V
E
A
L
A
N
---
F
--
P
I
E
---
R
D
L
V
V
-----
D
M
T
H
F
I
E
S
L
E
A
I
K
P
Y
I
I
G
N
S
R
T
--
A
D
Q
G
T
N
I
Q
T
P
A
Q
M
A
K
Y
H
Q
F
S
G
C
I
-
N
C
G
L
C
Y
A
A
C
P
Q
F
G
L
N
P
E
F
I
G
P
A
A
I
T
----
L
A
H
R
Y
N
E
D
S
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
V
-
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
K
H
V
D
P
A
A
A
I
Q
Q
G
K
V
E
S
S
K
-
D
F
L
I
A
T
L
K
P
-------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
25.93
40%
89
- C6 -
2B76
1
FRDB_ECOLI
B:
[59-83]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
I
--
C
---
G
S
C
-
G
M
M
V
N
N
V
P
K
L
A
-------------
C
K
T
F
L
--------------
R
D
Y
T
D
G
M
K
V
E
A
L
A
N
---
F
--
P
I
E
---
R
D
L
V
V
-----
D
M
T
H
F
I
E
S
L
E
A
I
K
P
Y
I
I
G
N
S
R
T
--
A
D
Q
G
T
N
I
Q
T
P
A
Q
M
A
K
Y
H
Q
F
S
G
C
I
-
N
C
G
L
C
Y
A
A
C
P
Q
F
G
L
N
P
E
F
I
G
P
A
A
I
T
----
L
A
H
R
Y
N
E
D
S
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
V
-
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
K
H
V
D
P
A
A
A
I
Q
Q
G
K
V
E
S
S
K
-
D
F
L
I
A
T
L
K
P
-------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
25.80
40%
91
- C6 -
1KF6
1
FRDB_ECOLI
B:
[59-83]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
I
--
C
---
G
S
C
-
G
M
M
V
N
N
V
P
K
L
A
-------------
C
K
T
F
L
--------------
R
D
Y
T
D
G
M
K
V
E
A
L
A
N
---
F
--
P
I
E
---
R
D
L
V
V
-----
D
M
T
H
F
I
E
S
L
E
A
I
K
P
Y
I
I
G
N
S
R
T
--
A
D
Q
G
T
N
I
Q
T
P
A
Q
M
A
K
Y
H
Q
F
S
G
C
I
-
N
C
G
L
C
Y
A
A
C
P
Q
F
G
L
N
P
E
F
I
G
P
A
A
I
T
----
L
A
H
R
Y
N
E
D
S
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
V
-
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
K
H
V
D
P
A
A
A
I
Q
Q
G
K
V
E
S
S
K
-
D
F
L
I
A
T
L
K
P
-------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
25.67
40%
103
- C6 -
1KFY
1
FRDB_ECOLI
B:
[59-83]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
I
--
C
---
G
S
C
-
G
M
M
V
N
N
V
P
K
L
A
-------------
C
K
T
F
L
--------------
R
D
Y
T
D
G
M
K
V
E
A
L
A
N
---
F
--
P
I
E
---
R
D
L
V
V
-----
D
M
T
H
F
I
E
S
L
E
A
I
K
P
Y
I
I
G
N
S
R
T
--
A
D
Q
G
T
N
I
Q
T
P
A
Q
M
A
K
Y
H
Q
F
S
G
C
I
-
N
C
G
L
C
Y
A
A
C
P
Q
F
G
L
N
P
E
F
I
G
P
A
A
I
T
----
L
A
H
R
Y
N
E
D
S
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
V
-
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
K
H
V
D
P
A
A
A
I
Q
Q
G
K
V
E
S
S
K
-
D
F
L
I
A
T
L
K
P
-------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
25.43
40%
95
- C6 -
3P4Q
1
FRDB_ECOLI
B:
[59-83]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
I
--
C
---
G
S
C
-
G
M
M
V
N
N
V
P
K
L
A
-------------
C
K
T
F
L
--------------
R
D
Y
T
D
G
M
K
V
E
A
L
A
N
---
F
--
P
I
E
---
R
D
L
V
V
-----
D
M
T
H
F
I
E
S
L
E
A
I
K
P
Y
I
I
G
N
S
R
T
--
A
D
Q
G
T
N
I
Q
T
P
A
Q
M
A
K
Y
H
Q
F
S
G
C
I
-
N
C
G
L
C
Y
A
A
C
P
Q
F
G
L
N
P
E
F
I
G
P
A
A
I
T
----
L
A
H
R
Y
N
E
D
S
R
D
H
G
K
K
E
R
M
A
Q
L
N
S
Q
N
G
V
-
W
S
C
T
F
V
G
Y
C
S
E
V
C
P
K
H
V
D
P
A
A
A
I
Q
Q
G
K
V
E
S
S
K
-
D
F
L
I
A
T
L
K
P
-------
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
24.87
15%
304
- C5 -
3B72
-
LYSC_CHICK
A:
[19-41]
----------------------------------------------------------------------------------------------------------
K
V
------------------------------
F
G
R
C
E
L
A
A
A
M
K
R
H
G
L
D
N
Y
R
G
Y
S
L
G
N
W
V
-----
C
A
A
K
F
E
S
------
N
F
N
T
Q
A
T
N
R
N
T
D
G
S
T
D
Y
G
I
--
L
Q
---
I
N
S
R
W
W
C
N
D
--
G
---
R
T
P
-
G
S
R
N
L
C
N
I
P
C
S
-------------
A
L
L
S
S
--------------
D
I
T
A
S
V
N
C
A
K
K
I
V
S
---
D
--
G
N
G
---
M
N
A
W
V
-----
A
W
R
N
R
C
K
G
T
D
V
Q
A
W
I
R
G
C
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------