@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S17A9_HUMAN: (2015-12-09 )
MQPPPDEARRDMAGDTQWSRPECQAWTGTLLLGTCLLYCARSSMPICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTPLLAHLSSAHLAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYLLSEKDLILALGVLAQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVPWLVAIPASLFSGFLSDHLINQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVVFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTGSWTCLFNLVAIISNLGLCTFLVFGQAQRVDLSSTHEDL
Atome Classification :
(20 SA)
....-------.....10........20........30..--......40......-..-50...-.....60.....------------...70...-----.....80......-..90...-..---...100.....--------------..110.....-..120.-......130.-.----......140.......-150-----.--..--....160.......170.......--------------------------180---.-.......190........200---------------------.---------------....----------------.-..210-----....-....220.......230---------......-..240--------------------------.......250.------......----260-......---.-----270....--....280........290.......300--........310.....-..320.......330.--.......340-........-350...----....360..-.-....370...-....380..-.....390.......400..----.....410...-...-.420.......430....----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQPP-------
P
D
E
A
R
RDMAGDTQWSRPEC
Q
A
W
T
G
T
L
L
L
G
--
T
C
L
L
Y
C
ARSSM
P
I
C
-
T
V
-SMSQD-FGWNKKEAG
I
V
L
------------
S
S
F
F
W
G
Y
C
-----
L
T
Q
V
V
G
G
H
L
GDRI-GG
E
K
V
I
L
-
L
S---ASAWG
S
I
T
A
V
T
--------------
P
L
L
A
H
L
S
S
A
H
-
L
A
F
M
T
F
-
S
R
I
L
M
G
L
-
L
Q
-
G
----
V
Y
F
P
A
L
T
S
L
L
S
Q
K
V
R
E
-SER-----
A
--
F
T
--
Y
S
I
VGAG
S
Q
F
G
T
L
L
T
G
A
V
G
S
L
L
L
E
--------------------------
W
Y----G-W
Q
S
I
F
Y
FSG-
G
L
T
L
L
W
V
W
Y
V
----------------------
Y
---------------
R
Y
L
L----------------S-EK
D
L
------
I
L
A
L
-
G
V
L
AQSRPVSRHNR
V
-
P
---------
W
R
R
L
FR-KP
A
V
W
--------------------------
A
A
V
V
S
Q
L
S
A
A
C
------
S
F
F
I
L
L
----
S
W
L
-
P
T
F
F
E
E
---T-----F-PDAK
G
--
W
I
F
N
V-
V
P
W
L
V
A
I
P
A
S
L
F
S
G
F
L
S
D
H
L
I
---NQG
Y
R
A
I
T
V
R
K
L
M
Q
G
M-GL
G
L
S
S
V
F
A
L
C
LG-
H
T
--
S
S
F
C
E
S
V
V
F
--ASASI
G
L
Q
-
T
FNHS
G
----
I
S
V
N
I
Q
DLA-
P
-
S
C
A
G
F
L
F
GVA-
N
T
A
G
A
L
A
G
V
-
V
G
V
C
LG
G
Y
L
M
ETTG
S
W
T
C
L
F
----
N
L
V
A
I
I
SNL
G
L
-
C
T
F
-
L
VFGQ
A
Q
RVDLSSTHEDL----------------
25
Fugue
83.89
15%
-101
- C5 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
F
K
P
A
-------
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
--
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
-
M
P
-
Y
L
-
V
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
------------
S
G
I
S
I
A
Y
G
-----
F
S
K
F
I
M
G
S
V
S
D
R
S
-
N
P
R
V
F
L
P
-
A
G
---
L
I
L
A
A
A
V
M
L
F
M
--------------
G
F
V
P
W
A
T
S
S
--
I
A
V
M
F
V
-
L
L
F
L
C
G
W
-
F
Q
-
G
----
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
-
K
E
R
-----
G
--
G
I
--
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
--------------------------
W
F
----
N
D
W
H
A
A
L
Y
M
P
A
-
F
C
A
I
L
V
A
L
F
A
----------------------
F
---------------
A
M
M
R
----------------
D
-
T
P
Q
S
------
C
G
L
P
-
P
--
I
E
E
Y
K
N
D
T
A
K
Q
I
-
F
---------
M
Q
Y
V
L
P
-
N
K
L
L
W
--------------------------
Y
I
A
I
A
N
V
F
V
Y
L
------
L
R
Y
G
I
L
----
D
W
S
-
P
T
Y
L
K
E
---
V
KH---
F
-
A
L
D
K
S
--
S
W
A
Y
F
-
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
---
R
-
G
N
R
G
A
T
G
V
F
F
M
T
L
V
-
T
I
A
T
I
V
Y
W
M
N
--
P
-
A
G
--
N
P
T
V
D
M
I
C
M
--
I
V
I
G
F
L
I
Y
-
G
P
V
M
L
I
----
G
L
H
A
L
E
L
A
P
-
K
-
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
-
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
----
M
V
M
I
G
G
S
I
L
A
V
-
I
L
L
-
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
VP--------------
13
HHSearch
82.61
17%
-103
- C5 -
1PW4
-
GLPT_ECOLI
A:
[7-448]
--
P
A
-------
P
H
K
A
R
L
P
A
A
E
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
G
--
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
-
M
P
-
Y
L
V
-
E
-
Q
G
F
S
R
G
D
L
G
F
A
L
------------
S
G
I
S
I
A
Y
G
-----
F
S
K
F
I
M
G
S
V
S
D
R
S
-
N
P
R
V
F
L
P
-
A
G
---
L
I
L
A
A
A
V
M
L
F
M
--------------
G
F
V
P
W
A
T
-
S
S
-
I
A
V
M
F
V
-
L
L
F
L
C
G
W
-
F
Q
-
G
----
M
G
W
P
P
C
G
R
T
M
V
H
W
W
S
Q
-
K
E
R
-----
G
--
G
I
--
V
S
V
W
N
C
A
H
N
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
W-------------------------
F
N
----
D
-
W
H
A
A
L
Y
M
P
A
-
F
C
A
I
L
V
A
L
F
A
----------------------
F
---------------
A
M
M
R
----------------
D
T
P
Q
S
C
------
G
L
P
P
I
E
E
Y
K
N
D
-----
T
A
K
Q
I
F
---------
M
Q
Y
V
L
P
-
N
K
L
L
W
--------------------------
Y
I
A
I
A
N
V
F
V
Y
L
------
L
R
Y
G
I
L
----
D
W
S
-
P
T
Y
L
K
E
---
V
KH---
F
-
A
L
D
K
S
--
S
W
A
Y
F
-
L
Y
E
Y
A
G
I
P
G
T
L
L
C
G
W
M
S
D
K
V
F
---
R
G
N
------
R
G
A
T
G
V
F
-
F
M
T
L
V
T
I
A
T
I
V
Y
W
-
M
N
PA
G
N
P
T
V
D
M
I
C
--
M
I
-
V
I
G
F
L
I
Y
G
P
V
M
L
----
I
G
L
H
A
L
E
L
A
-
P
K
K
A
A
G
T
A
A
G
F
T
-
G
L
F
G
Y
L
G
G
S
V
A
A
S
A
I
V
G
Y
T
V
D
F
F
G
-
W
D
G
G
F
----
M
V
M
I
G
G
S
I
L
A
V
-
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
----------------
33
Fugue
72.49
19%
-110
- C5 -
3WDO
-
?
A:
[1-453]
---------------------
D
Y
K
M
T
P
G
E
R
R
A
T
W
G
L
G
T
V
F
--
S
L
R
M
L
G
M
F
M
V
L
P
V
L
-
T
T
-
Y
G
M
A
L
-
Q
G
A
S
E
A
L
I
G
I
A
I
------------
G
I
Y
G
L
T
Q
A
-----
V
F
Q
I
P
F
G
L
L
S
D
R
I
-
G
R
K
P
L
I
V
-
G
G
---
L
A
V
F
A
A
G
S
V
I
A
--------------
A
L
-----
S
D
S
-
I
W
G
I
I
L
-
G
R
A
L
Q
G
S
----
G
----
A
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
-
Q
N
R
-----
T
--
K
A
--
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
----
G
-
L
H
A
L
F
W
M
I
A
-
I
L
A
T
T
G
I
A
L
T
I
W
V
VPNS
S
T
H
V
L
N
R
E
SGMV
K
G
S
F
---------------
S
K
V
L
----------------
A
-
E
P
R
L
L
K
L
N
F
G
I
M
C
L
-
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
-
A
D
A
GFP
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
--------------------------
G
S
V
V
P
F
I
I
Y
A
E
VKRK
M
K
Q
V
F
V
F
C
----
V
G
L
-
I
V
V
A
E
I
---
V
-----
L
-
W
N
A
Q
T
Q
F
W
Q
L
V
V
-
G
V
Q
L
F
F
V
A
F
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
P
A
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
-
F
L
G
V
A
I
G
G
S
L
G
G
W
-
I
D
--
G
M
F
D
G
Q
G
V
F
--
L
A
G
A
M
L
A
A
-
V
W
L
A
V
A
----
S
T
M
K
---
E
P
-
P
-
Y
V
S
S
L
R
I
E
I
P
-
A
D
I
A
A
------
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
AEEE
H
S
A
Y
V
K
I
D
S
K
V
-
T
N
R
-
F
E
V
E
Q
A
I
R
Q
A
L
-----------------------
27
Fugue
70.95
13%
-92
- C5 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
----------------------------
L
L
L
M
L
V
L
L
V
A
V
G
--
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
-
A
-----
R
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
------------
G
A
Y
L
L
T
Y
G
-----
V
S
Q
L
F
Y
G
P
I
S
D
R
V
-
G
R
R
P
V
I
L
-
V
G
---
M
S
I
F
M
L
A
T
L
V
A
--------------
V
T
T
S
S
L
T
V
------
L
I
A
-
A
S
A
M
Q
G
M
-
G
T
-
G
----
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
-
T
Q
L
-----
R
--
H
A
--
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
----
N
-
W
R
A
C
Y
L
F
L
L
-
V
L
C
A
G
V
T
F
S
M
----------------------
A
---------------
R
W
M
P
----------------
E
-
T
R
-----------------
P
V
D
A
P
R
T
R
L
L
T
-
S
---------
Y
K
T
L
F
G
-
N
S
G
F
N
--------------------------
C
Y
L
L
M
L
I
G
G
L
A
------
G
I
A
A
F
E
----
A
C
S
-
G
V
L
M
G
A
---
V
-----
L
-
G
L
S
S
M
--
T
V
S
I
L
-
F
I
--
L
P
I
P
A
A
F
F
G
A
W
F
A
G
R
P
N
---
K
R
F
S
T
L
M
W
Q
S
V
I
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
V
M
-
N
V
--
W
T
L
L
V
P
A
A
L
--
F
F
F
G
A
G
M
L
-
F
P
L
A
T
S
----
G
A
M
E
P
F
P
F
L
-
A
-
G
T
A
G
A
L
V
G
G
L
-
Q
N
I
G
S
G
--
V
-
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
M
----
T
L
M
G
L
L
I
V
L
C
W
-
L
P
L
-----------------------------------
14
HHSearch
70.70
13%
-98
- C5 -
3O7Q
1
FUCP_ECOLI
A:
[33-420]
--------------------------------------
S
L
--
F
F
L
W
A
V
A
N
N
L
N
D
I
L
-
L
P
-
Q
F
Q
Q
A
-
F
T
L
T
N
F
Q
A
G
L
I
Q
------------
S
A
F
Y
F
G
Y
F
-----
I
I
P
I
P
A
G
I
L
M
K
K
L
-
S
Y
K
A
G
I
I
-
T
G
---
L
F
L
Y
A
L
G
A
A
L
F
--------------
W
P
A
A
E
I
M
N
---
Y
T
L
F
L
V
-
G
L
F
I
I
A
A
-
G
L
-
G
----
C
L
E
T
A
A
N
P
F
V
T
V
L
G
P
E
-
S
S
G
-----
H
--
F
R
--
L
N
L
A
Q
T
F
N
S
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
----
S
-
V
Q
T
P
Y
M
I
I
V
-
A
I
V
L
L
V
A
L
L
I
----------------------
M
----------------
L
T
K
----------------
F
-
P
A
L
Q
------
S
D
N
------
H
S
D
A
K
Q
G
S
F
S
A
-
S
---------
L
S
R
L
A
R
-
I
R
H
W
R
--------------------------
W
A
V
L
A
Q
F
C
Y
V
G
------
A
Q
T
A
C
W
----
S
Y
L
-
I
R
Y
A
V
E
---
E
IPG--
M
-
T
A
G
F
A
--
A
N
Y
L
T
-
G
T
M
V
C
F
F
I
G
R
F
T
G
T
W
L
I
S
R
F
A
---
P
--------
H
K
V
L
A
A
--
Y
A
L
I
A
M
A
L
C
L
I
S
A
-
F
A
--
G
G
H
V
-
G
L
I
A
--
L
T
L
C
S
A
F
M
-
S
I
Q
Y
P
T
----
I
F
S
L
G
I
K
N
L
-
G
-
Q
D
T
K
Y
G
S
S
F
I
--
V
M
T
I
I
G
G
G
-
I
V
T
P
V
M
G
F
V
S
D
A
A
G
N
I
P
T
A
E
----
L
I
P
A
L
C
F
A
V
I
F
-
I
F
A
-
R
F
R
S
Q
T
----------------------------
31
Fugue
70.19
19%
-112
- C3 -
4RAP
-
TIBC_ECOH1
A:
[10-391]
I
T
P
P
DTPT
Q
A
G
P
E
N
I
F
Y
D
F
N
D
G
A
R
V
L
L
P
E
G
K
-
W
H
V
R
L
L
D
---------
A
D
S
E
N
I
L
F
-
C
C
-
D
V
D
K
G
-
W
V
T
S
S
K
K
Y
F
V
R
F
------------
R
I
Q
V
F
R
Q
G
-----
A
T
P
L
L
D
E
T
L
--
K
L
-
K
D
R
P
V
L
I
S
F
P
---
T
G
T
L
G
D
L
L
G
W
F
--------------
P
Y
A
E
R
F
Q
S
L
H
K
C
R
L
E
C
T
M
S
Q
D
I
I
D
L
-
L
A
-
P
----
Q
Y
-
P
Q
I
Q
F
S
T
P
D
K
P
R
T
-
V
A
P
-----
Y
--
A
T
--
Y
R
V
G
----------------------------------------------------------
L
Y
F
G
G
-
D
T
N
N
Q
P
V
D
------------------------
F
---------------
R
K
V
G
----------------
F
-
H
R
S
A
------
G
Y
I
L
-
G
V
D
P
R
E
A
P
V
R
L
D
L
S
A
-
P
-----------
R
V
I
A
-
A
P
Y
V
C
--------------------------
I
A
T
Q
S
T
C
Q
A
K
-----------------
Y
W
N
N
G
T
G
W
S
E
---
V
-----
I
-
A
H
L
K
S
--
L
G
Y
R
V
M
C
---
I
D
R
D
A
H
Y
G
Q
G
F
V
W
N
H
-
I
---
P
W
G
A
E
D
F
T
G
K
L
P
L
Q
E
R
-
V
N
L
L
R
H
A
-
S
F
F
I
G
-------
L
P
S
G
L
S
W
--
L
A
W
A
T
R
I
P
-
V
V
L
I
S
G
----
F
S
--
L
P
N
S
E
-
F
-
Y
T
P
W
R
V
F
N
S
H
-
G
C
Y
G
C
W
D
D
T
------
S
L
N
F
D
H
H
D
F
L
W
C
P
R
H
----
K
N
T
---
D
R
Q
F
E
-
C
T
R
-
L
I
T
G
A
Q
V
N
G
V
I
N
K
L
H
R
S
L
T---------------
29
Fugue
69.86
15%
-111
- C5 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
-------------------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
V
A
-
P
Q
N
L
S
-
E
S
A
A
N
S
L
L
G
F
C
V
------------
A
S
A
L
I
G
C
I
-----
I
G
G
A
L
G
G
Y
C
S
N
R
F
-
G
R
R
D
S
L
K
-
I
A
---
A
V
L
F
F
I
S
G
V
G
S
A
WPELGFTSINPDN
T
V
P
V
Y
L
A
G
Y
V
-
P
E
F
V
I
Y
--
R
I
I
G
G
I
-
G
V
-
G
----
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
-
H
I
R
-----
G
--
K
L
--
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
------------------
T
D
----
G
-
W
R
Y
M
F
A
S
E
C
-
I
P
A
L
L
F
L
M
L
L
----------------------
Y
T
VPES
P
---------
R
W
L
M
S
R
GK
Q
E
Q
A
E
G
I
L
R
K
I
M
G
-
N
T
L
A
------
T
Q
A
V
-
Q
E
I
K
H
S
L
D
H
G
R
K
T
G
G
-
R
---------
L
L
M
F
G
V
-
G
V
I
V
I
--------------------------
G
V
M
L
S
I
F
Q
Q
F
V
------
G
I
N
V
V
L
----
Y
Y
A
-
P
E
V
F
K
T
---
L
-----
G
-
A
S
T
D
I
--
A
L
L
Q
T
-
I
---
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
---
D
K
F
G
R
K
P
L
Q
I
I
G
A
L
G
M
-
A
I
G
M
F
S
L
G
T
A
F
Y
T
-
Q
A
--
P
---
G
I
V
A
L
--
L
S
M
L
F
Y
V
A
-
A
F
A
M
S
---------
W
G
P
V
C
-
W
-
V
L
L
S
E
I
F
P
N
A
-
I
R
G
K
A
L
A
I
A
-
V
A
A
Q
W
L
A
N
Y
F
V
S
W
-
T
F
P
M
M
D
----
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
-
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
PETKGKTLEELEALWE
34
Fugue
68.56
17%
-107
- C2 -
2CY7
-
ATG4B_HUMAN
A:
[5-377]
-
T
L
T
-------
Y
D
T
L
R
F
A
E
F
E
D
-------------------------
F
P
E
T
S
E
P
V
W
-
I
L
-
G
R
K
Y
S
-
I
F
T
E
K
D
E
I
L
S
D
V
------------
A
S
R
L
W
F
T
Y
-----
R
K
N
F
------
P
A
I
-
G
G
T
G
--
P
-
T
S
---
D
T
G
W
G
C
M
L
R
C
G
--------------
Q
M
I
F
A
Q
A
L
V
C
-
R
H
L
G
R
D
-
W
R
W
T
Q
R
K
-
R
Q
P
D
----
S
Y
F
S
V
L
N
A
F
I
D
R
K
D
S
Y
Y
S
I
H
-----
Q
--
I
A
--
Q
M
G
V
G
E
G
K
S
I
G
------------
Q
--------------------------
W
Y
----
G
-
P
N
T
V
A
Q
V
L
K
-
K
L
A
V
F
D
T
W
S
S
----------------------
L
---------------
A
V
H
I
----------------
A
-
M
D
N
T
------
V
V
M
E
-
E
I
R
R
L
C
R
T
S
V
P
C
S
---
P
---------
W
R
--------------------------------------------------------------------------------------------------
P
L
V
L
L
I
P
L
R
L
-----
G
L
T
D
I
---
N
E
A
Y
V
E
T
L
K
H
C
F
M
M
P
Q
-
S
L
G
-------
V
I
G
-
G
K
--
P
N
S
A
-
H
Y
F
I
--
G
Y
V
G
E
E
L
I
-
Y
L
D
P
H
T
----
T
Q
P
A
V
E
G
C
F
-
I
-
P
D
E
S
F
H
C
Q
H
P
-
P
C
R
M
S
I
A
E
L
-
D
P
S
I
A
V
G
F
F
C
K
T
E
D
D
F
N
D
W
C
----
Q
Q
V
K
K
L
S
L
L
P
M
-
F
E
L
-
V
E
Q
-
Q
P
D
V
L
N
L
S
L
D
S
S
D
V
E
R
L-------------
16
HHSearch
68.07
14%
-95
- C5 -
2GFP
-
EMRD_ECOLI
A:
[18-360]
-------------------------------------------
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
-
I
A
-
D
M
A
R
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
------------
G
A
Y
L
L
T
Y
G
-----
V
S
Q
L
F
Y
G
P
I
S
D
R
V
-
G
R
R
P
V
I
L
-
V
G
---
M
S
I
F
M
L
A
T
L
V
A
--------------
V
T
T
S
S
------
L
T
V
L
I
A
-
A
S
A
M
Q
G
M
-
G
T
-
G
----
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
-
T
Q
L
-----
R
--
H
A
--
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
----
N
-
W
R
A
C
Y
L
F
L
L
-
V
L
C
A
G
V
T
F
S
M
----------------------
A
---------------
R
W
M
P
----------------
E
---
T
R
------
P
V
D
---------
A
P
R
T
R
L
L
T
-
S
---------
Y
K
T
L
F
G
-
N
S
G
F
N
--------------------------
C
Y
L
L
M
L
I
G
G
L
A
------
G
I
A
A
F
E
----
A
C
S
-
G
V
L
M
G
A
---
V
L
G
---
L
-
S
S
M
T
V
--
S
I
L
F
I
-
L
P
I
P
A
A
----
F
F
G
A
W
F
A
G
R
P
N
---
K
R
F
----
S
T
L
M
W
Q
S
V
I
-
C
C
L
L
A
G
L
L
M
W
I
P
D
-
W
F
G
V
M
N
V
W
T
L
L
V
P
--
A
A
L
F
F
F
G
A
-
G
M
L
F
P
L
----
A
T
S
G
A
M
E
P
F
-
P
-
F
L
A
G
T
A
G
A
L
V
-
G
G
L
Q
N
I
G
S
G
-
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
G
L
L
----
M
T
L
M
G
L
L
I
V
L
C
-
W
L
P
-
L
---------------------------------
15
HHSearch
68.04
16%
-111
- C5 -
3WDO
-
?
A:
[20-377]
-------------------------------------------
S
L
R
M
L
G
M
F
M
V
L
P
V
-
L
T
T
Y
G
M
A
L
-
Q
G
A
S
E
A
L
I
G
I
A
I
------------
G
I
Y
G
L
T
Q
A
-----
V
F
Q
I
P
F
G
L
L
S
D
R
I
-
G
R
K
P
L
I
V
-
G
G
---
L
A
V
F
A
A
G
S
V
I
A
--------------
A
L
S
D
S
------
I
W
G
I
I
L
-
G
R
A
L
Q
G
S
-
G
A
-------
I
A
A
A
V
M
A
L
L
S
D
L
T
R
E
-
Q
N
R
-----
T
--
K
A
--
M
A
F
I
G
V
S
F
G
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
L
----
G
-
L
H
A
L
F
W
M
I
A
-
I
L
A
T
T
G
I
A
L
T
----------------------
I
---------------
W
V
V
P
----------------
N
S
S
T
H
V
------
L
N
----------
R
E
S
G
M
V
K
G
-
S
---------
F
S
K
V
L
A
-
E
P
R
L
L
--------------------------
K
L
N
F
G
I
M
C
L
H
M
------
L
L
M
S
T
F
----
V
A
L
-
P
G
Q
L
A
D
---
A
G----
F
-
P
A
A
E
H
--
W
K
V
Y
L
-
A
T
M
-
L
I
A
F
G
S
V
V
P
F
I
I
Y
A
E
V
K
---
R
K
-----
M
-
K
Q
V
F
V
-
F
-
C
V
G
L
I
V
V
A
E
I
V
L
W
N
A
Q
--
T
Q
F
W
Q
L
V
V
G
--
V
Q
L
F
F
V
A
F
-
N
L
M
E
A
L
----
L
P
S
L
I
S
K
E
S
-
P
A
G
Y
K
G
T
A
M
G
V
Y
-
S
T
S
Q
F
L
G
V
A
-
I
G
G
S
L
G
G
W
I
D
G
M
F
D
-
G
Q
G
V
F
----
L
A
G
A
M
L
A
A
V
W
L
-
A
V
A
-
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
----------------
26
Fugue
67.22
13%
-103
- C5 -
1PV6
-
LACY_ECOLI
A:
[1-417]
M
Y
Y
L
-------
K
N
-----------------
T
N
F
W
M
F
G
L
F
F
--
F
F
Y
F
F
I
M
G
A
Y
F
P
F
F
-
P
I
-
W
L
H
D
I
-
N
H
I
S
K
S
D
T
G
I
I
F
------------
A
A
I
S
L
F
S
L
-----
L
F
Q
P
L
F
G
L
L
S
D
K
L
-
G
-
L
R
K
Y
L
-
L
W
---
I
I
T
G
M
L
V
M
F
A
P
--------------
F
F
I
F
I
F
G
P
L
L
-
Q
Y
N
I
L
V
-
G
S
I
V
G
G
I
-
Y
L
-
G
----
F
C
F
N
A
G
A
P
A
V
E
A
F
I
E
K
-
V
S
R
-----
R
SN
F
E
--
F
G
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
--------------------------
I
-----
N
-
N
Q
F
V
F
W
L
G
S
-
G
C
A
L
I
L
A
V
L
L
----------------------
F
---------------
F
A
K
T
----------------
D
-
A
P
S
S
--------
A
T
-
V
A
N
A
V
G
A
N
H
S
A
F
S
L
K
-
L
---------
A
L
E
L
F
R
-
Q
P
K
L
W
--------------------------
F
L
S
L
Y
V
I
G
V
S
C
------
T
Y
D
V
F
D
----
Q
Q
F
-
A
N
F
F
T
S
---
F
-----
F
-
A
T
G
E
Q
--
G
T
R
V
F
----
G
Y
V
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
---
P
L
I
I
N
R
I
G
G
K
N
A
L
L
L
A
-
G
T
I
M
S
V
R
I
I
G
S
S
F
-
A
T
--
S
A
L
E
V
V
I
L
K
--
T
L
H
M
F
E
V
P
-
F
L
L
V
G
C
----
F
K
Y
I
T
S
Q
F
E
-
V
-
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
----
V
L
G
L
V
A
L
G
F
T
L
-
I
S
V
-
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A--------------
17
HHSearch
62.46
15%
-102
- C5 -
2CFQ
-
LACY_ECOLI
A:
[17-391]
-------------------------------------------
F
F
Y
F
F
I
M
G
A
Y
F
P
F
-
F
P
-
I
W
L
H
D
I
N
H
I
S
K
S
D
T
G
I
I
F
------------
A
A
I
S
L
F
S
L
-----
L
F
Q
P
L
F
G
L
L
S
D
K
L
-
G
L
R
K
Y
L
L
-
W
I
I
T
G
M
L
V
M
F
A
P
F
F
I
F
--------------
I
F
G
P
L
--
L
---
Q
Y
N
I
L
V
-
G
S
I
V
G
G
I
-
Y
L
-
G
FCFN
A
G
A
P
A
V
E
A
F
I
E
K
V
S
R
---
R
S
-----
N
--
F
E
--
F
G
R
A
R
M
F
G
C
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
---------------------------
I
----
N
-
N
Q
F
V
F
W
L
G
S
-
G
C
A
L
I
L
A
V
L
L
--------------------------------------
F
F
A
K
----------------
T
-
D
A
P
S
------
S
A
T
V
-
A
-
N
A
V
G
A
N
H
S
A
F
S
L
K
-
L
---------
A
L
E
L
F
R
-
Q
P
K
L
W
--------------------------
F
L
S
L
Y
V
I
G
V
S
C
------
T
Y
D
V
F
D
----
Q
Q
F
-
A
N
F
F
T
S
---
F
FAT
G
E
Q
-
G
T
R
V
F
--
G
Y
V
T
T
-
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
N
R
I
G
---
G
--------
K
N
A
L
-
L
L
-
A
G
T
I
M
S
V
R
I
I
G
S
S
-
F
A
--
T
S
A
L
E
-
V
V
I
--
L
---
K
T
L
H
-
M
F
E
V
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
E
V
-
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
K
Q
L
A
M
I
-
F
M
S
V
L
A
G
N
M
Y
E
S
I
G
-
F
Q
G
A
Y
----
L
V
L
G
L
V
A
L
G
F
T
-
L
I
S
-
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
----------------
28
Fugue
61.00
11%
-85
- C5 -
2XUT
-
?
A:
[13-500]
--------------
Q
I
P
Y
I
I
A
S
E
A
C
E
R
F
S
F
Y
G
M
R
N
I
L
T
P
F
--
L
M
T
------------
A
L
-
L
L
S
I
P
-
E
E
L
R
G
A
V
A
K
D
V
F
------------
H
S
F
V
I
G
V
Y
-----
F
F
P
L
L
G
G
W
I
A
D
R
F
-
F
G
K
Y
N
T
I
-
L
W
---
L
S
L
I
-
Y
C
V
G
H
A
--------------
F
L
A
I
F
E
H
S
V
Q
-
G
F
Y
T
G
L
-
F
L
I
A
L
G
S
G
G
I
-
K
----
P
L
V
S
S
F
M
G
D
Q
F
D
Q
S
N
K
-
S
L
A
-----
Q
--
K
A
--
F
D
M
F
Y
F
T
I
N
F
G
S
F
F
A
S
L
S
M
P
L
L
L
K
--------------------------
N
F
----
G
-
A
A
V
A
F
G
I
P
G
V
L
M
F
V
A
T
V
F
F
W
----------------------
L
G
RK
R
Y
I
H
M
PV
E
G
K
G
N
I
G
L
V
----------------
L
-
A
L
I
G
------
G
V
S
A
-
A
Y
A
L
V
N
I
P
T
L
G
I
V
A
G
-
L
---------
C
C
A
M
V
L
-
V
M
G
F
V
G
AGA
S
L
Q
L
E
R
A
RKSHPD
A
A
V
D
G
V
R
S
V
L
R
I
L
V
L
F
A
L
V
T
------
P
F
W
S
L
F
D
Q
K
A
S
T
W
-
I
L
Q
A
N
D
MVK
P
-----
Q
-
W
F
E
P
A
--
M
M
Q
A
L
-
N
P
L
L
V
M
L
L
I
P
F
N
N
F
V
T
A
L
R
K
M
---
G
A
G
I
A
I
T
G
L
S
W
I
V
-----
V
G
T
I
Q
L
M
M
D
G
G
S
-
A
L
--
S
I
F
W
Q
I
L
P
Y
--
A
L
L
T
F
G
E
V
-
L
V
S
A
T
G
----
L
E
F
A
Y
S
Q
A
P
-
K
-
A
M
K
G
T
I
M
S
F
W
-
T
L
S
V
T
V
G
N
L
-
W
V
L
L
A
N
V
S
V
--
K
S
P
T
V
T
E
Q
I
----
V
Q
T
G
M
S
V
T
A
F
Q
-
M
F
F
-
F
A
G
F
A
I
L
A
A
I
V
F
A
---------------------
20
HHSearch
51.38
17%
-105
- C5 -
3WDO
-
?
A:
[12-175]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
--------------------------
G
L
G
T
V
F
S
L
R
M
L
------
G
M
F
M
V
L
----
P
V
L
-
T
T
Y
G
M
A
---
L
QG---
A
-
S
E
A
L
I
--
G
I
A
I
G
-
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
---
R
--------
K
P
L
-
I
V
G
-
G
L
A
V
F
A
A
G
S
V
I
A
A
-
L
S
--
D
S
I
W
G
I
I
-
L
--
G
R
A
L
Q
G
S
--
G
A
I
A
A
A
----
V
M
A
L
L
S
D
L
T
-
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
F
G
I
T
F
A
-
I
A
M
V
L
G
P
I
I
T
H
K
L
G
-
L
H
A
L
F
----
W
M
I
A
I
L
A
T
T
G
I
-
A
L
T
-
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
----------------
30
Fugue
45.78
14%
-142
- C5 -
4D9O
-
VP24_EBORE
A:
[10-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
P
K
K
D
M
E
K
G
V
I
F
S
D
L
C
N
--------------------------
F
L
----
I
-
T
Q
T
L
----
Q
-
G
W
K
V
Y
W
A
G
I
E
----------------------
F
---------------
D
V
S
Q
----------------
K
-
G
M
A
L
------
L
T
R
L
-
K
--------
T
A
M
T
R
N
-
L
---------
F
P
H
L
F
Q
-
N
P
N
-----------------------------
S
V
I
Q
S
P
I
W
A
L
------
R
V
I
L
A
A
----
G
L
Q
-
D
Q
L
L
D
H
---
S
-----
L
V
E
P
L
T
G
--
A
L
G
L
I
-
S
D
W
L
L
T
T
T
S
T
H
F
N
--
L
R
T
R
S
V
---
K
D
Q
L
S
L
R
M
L
S
L
I
R
S
N
I
-
L
Q
F
I
N
K
L
D
A
L
H
V
V
-
N
Y
--
N
G
L
L
S
S
I
E
I
G
T
S
T
H
T
I
I
I
T
-
R
T
N
-
M
G
----
F
L
V
E
V
Q
E
V
-------
K
F
S
L
L
H
E
-
S
A
F
K
P
F
T
-----------------------------------------------------------------------------
4
PsiBlast_PDB
45.20
24%
-102
- C5 -
4TPJ
2
?
A:
[8-182]
---------------------------------------------
V
S
K
T
H
S
F
M
T
V
S
-
L
I
-
E
L
W
E
R
-
F
G
Y
Y
G
M
Q
A
L
I
V
Y
F
M
V
QRLGFD
D
S
R
A
N
L
V
W
S
A
C
A
A
L
I
Y
V
S
P
A
I
G
G
W
V
G
D
K
I
L
G
T
K
R
T
M
L
-
L
G
---
A
----
G
I
L
S
V
G
--------------
Y
A
L
M
T
V
P
T
E
N
-
T
W
F
M
F
S
-
A
L
G
V
I
V
V
-
G
N
-
G
----
L
F
K
P
N
A
G
N
L
V
-
R
K
I
Y
E
----SK
I
D
S
A
--
F
T
I
Y
Y
M
A
V
N
V
G
S
T
F
S
M
L
L
T
P
W
I
K
D
Y
V
N
A
--------------------------
Q
Y
GNEF
G
-
W
H
A
A
F
A
V
C
C
-
V
G
I
L
V
G
L
G
N
Y
----------------------
A
---------------
L
M
H
K
----------------
S
-
L
A
N
Y
------
G
S
E
P
-
D
T
R
P
V
N
K
K
S
L
A
I
V
L
A
-
L
---------
A
A
L
S
V
V
-
A
S
A
I
I
--------------------------
L
E
Y
E
D
V
A
R
V
F
V
------
Y
A
A
G
V
A
----
V
L
G
-
I
I
A
A
L
I
---
L
-----
T
-
V
Q
T
V
F
--
F
F
I
F
Y
-
Q
Q
M
S
T
S
L
A
L
F
A
L
R
N
V
D
W
D
F
Q
V
---
F
G
T
H
L
W
T
W
S
P
A
Q
F
Q
A
L
-
N
P
I
W
I
M
V
L
S
P
V
L
A
-
W
I
--
A
A
K
F
A
L
G
F
A
--
V
V
A
I
G
F
F
I
-
Y
G
F
A
G
Q
----
F
A
V
N
G
K
T
S
S
-
W
-
V
M
I
W
G
Y
A
S
Y
S
-
L
G
E
L
L
V
S
G
L
-
G
L
A
M
I
A
R
Y
M
M
G
A
Y
F
V
A
S
G
I
S
----
Q
Y
L
G
G
V
V
A
N
F
A
-
S
V
P
-
Q
D
L
V
D
P
L
Q
T
L
P
V
Y
T
N
L
F
N
----------------
3
PsiBlast_PDB
44.63
24%
-99
- C5 -
4TPH
3
?
A:
[8-182]
---------------------------------------------
V
S
K
T
H
S
F
M
T
V
S
-
L
I
-
E
L
W
E
R
-
F
G
Y
Y
G
M
Q
A
L
I
V
Y
F
M
V
QRLGFD
D
S
R
A
N
L
V
W
S
A
C
A
A
L
I
Y
V
S
P
A
I
G
G
W
V
G
D
K
I
L
G
T
K
R
T
M
L
-
L
G
---
A
----
G
I
L
S
V
G
--------------
Y
A
L
M
T
V
P
T
E
N
-
T
W
F
M
F
S
-
A
L
G
V
I
V
V
-
G
N
-
G
----
L
F
K
P
N
A
G
N
L
V
-
R
K
I
Y
E
----SKI
D
S
A
--
F
T
I
Y
Y
M
A
V
N
V
G
S
T
F
S
M
L
L
T
P
W
I
K
D
Y
V
N
A
--------------------------
Q
Y
GNEF
G
-
W
H
A
A
F
A
V
C
C
-
V
G
I
L
V
G
L
G
N
Y
----------------------
A
---------------
L
M
H
K
----------------
S
-
L
A
N
Y
------
G
S
E
P
-
D
T
R
P
V
N
K
K
S
L
A
I
V
L
A
-
L
---------
A
A
L
S
V
V
-
A
S
A
I
I
--------------------------
L
E
Y
E
D
V
A
R
V
F
V
------
Y
A
A
G
V
A
----
V
L
G
-
I
F
F
H
L
E
---
R
-----
A
-
G
L
I
A
A
--
L
I
L
T
V
-
Q
T
V
F
F
F
I
F
Y
Q
Q
M
S
T
S
L
A
L
F
A
L
---
R
N
V
D
W
D
F
Q
V
F
G
T
H
L
W
T
-
W
S
P
A
Q
F
Q
A
L
N
P
I
W
-
I
M
--
V
L
S
P
V
L
A
W
I
--
A
A
K
F
A
L
G
F
-
A
V
V
A
I
G
----
F
F
I
Y
G
F
A
G
Q
-
F
-
A
V
N
G
K
T
S
S
W
V
-
M
I
W
G
Y
A
S
Y
S
-
L
G
E
L
L
V
S
G
L
G
L
A
M
I
A
R
M
M
G
A
----
Y
F
V
A
S
G
I
S
Q
Y
L
-
G
G
V
-
V
A
N
F
A
S
V
P
Q
D
L
V
D
P
L
Q
T
L
----------------
1
PsiBlast_PDB
43.85
24%
-96
- C5 -
4LEP
1
?
A:
[9-182]
----------------------------------------------
S
K
T
H
S
F
M
T
V
S
-
L
I
-
E
L
W
E
R
-
F
G
Y
Y
G
M
Q
A
L
I
V
Y
F
M
V
QRLGFD
D
S
R
A
N
L
V
W
S
A
C
A
A
L
I
Y
V
S
P
A
I
G
G
W
V
G
D
K
I
L
G
T
K
R
T
M
L
-
L
G
---
A
----
G
I
L
S
V
G
--------------
Y
A
L
M
T
V
P
T
E
N
-
T
W
F
M
F
S
-
A
L
G
V
I
V
V
-
G
N
-
G
----
L
F
K
P
N
A
G
N
L
V
-
R
K
I
Y
E
-
G
D
D
S
K
I
D
S
A
--
F
T
I
Y
Y
M
A
V
N
V
G
S
T
F
S
M
L
L
T
P
W
I
K
D
Y
V
N
A
--------------------------
Q
Y
GNEF
G
-
W
H
A
A
F
A
V
C
C
-
V
G
I
L
V
G
L
G
N
Y
----------------------
A
---------------
L
M
H
K
----------------
S
-
L
A
N
Y
------
G
V
N
K
-
K
S
L
A
I
V
L
A
L
A
A
L
S
V
V
-
A
---------
S
A
I
I
L
E
-
Y
E
D
V
A
--------------------------
R
V
F
V
Y
A
A
G
V
A
V
------
L
G
I
F
F
H
----
L
I
R
-
P
S
E
R
A
G
---
L
-----
I
-
A
A
L
I
L
--
T
V
Q
T
V
-
F
F
F
I
F
Y
Q
Q
M
S
T
S
L
A
L
F
A
L
R
N
V
---
D
W
D
F
W
T
W
S
P
A
Q
F
Q
A
L
N
-
P
I
W
I
M
V
L
S
P
V
L
A
W
-
S
Y
--
S
W
D
F
S
I
A
A
K
--
F
A
L
G
F
A
V
V
-
A
I
G
F
F
I
----
Y
G
F
A
G
Q
F
A
V
-
N
-
G
K
T
S
S
W
V
M
I
W
-
G
Y
A
S
Y
S
L
G
E
-
L
L
V
S
G
L
G
L
A
M
I
A
R
Y
G
F
M
M
G
A
----
Y
F
V
A
S
G
I
S
Q
Y
L
-
G
G
V
-
V
A
N
F
A
S
V
P
Q
D
L
V
D
P
L
Q
T
L
----------------
2
PsiBlast_PDB
43.02
24%
-102
- C5 -
4TPG
2
?
A:
[8-182]
---------------------------------------------
V
S
K
T
H
S
F
M
T
V
S
-
L
I
-
E
L
W
E
R
-
F
G
Y
Y
G
M
Q
A
L
I
V
Y
F
M
V
QRLGFD
D
S
R
A
N
L
V
W
S
A
C
A
A
L
I
Y
V
S
P
A
I
G
G
W
V
G
D
K
I
L
G
T
K
R
T
M
L
-
L
G
---
A
----
G
I
L
S
V
G
--------------
Y
A
L
M
T
V
P
T
E
N
-
T
W
F
M
F
S
-
A
L
G
V
I
V
V
-
G
N
-
G
----
L
F
K
P
N
A
G
N
L
V
-
R
K
I
Y
E
----SK
I
D
S
A
--
F
T
I
Y
Y
M
A
V
N
V
G
S
T
F
S
M
L
L
T
P
W
I
K
D
Y
V
N
A
--------------------------
Q
Y
GNEF
G
-
W
H
A
A
F
A
V
C
C
-
V
G
I
L
V
G
L
G
N
Y
----------------------
A
---------------
L
M
H
K
----------------
S
-
L
A
N
Y
------
G
S
E
P
-
D
T
R
P
V
N
K
K
S
L
A
I
V
L
A
-
L
---------
A
A
L
S
V
V
-
A
S
A
I
I
--------------------------
L
E
Y
E
D
V
A
R
V
F
V
------
Y
A
A
G
V
A
----
V
L
G
-
I
F
F
H
L
I
---
R
-----
P
-
S
E
R
A
G
--
L
I
A
A
L
-
I
L
T
V
Q
T
V
F
F
F
I
F
Y
Q
Q
M
S
T
S
L
A
---
L
F
A
L
R
N
V
D
W
D
F
Q
V
F
G
T
-
H
L
W
T
W
S
P
A
Q
F
Q
A
L
-
N
P
--
I
W
I
M
V
L
S
P
V
--
L
A
W
I
A
A
K
F
-
A
L
G
F
A
V
----
V
A
I
G
F
F
I
Y
G
-
F
-
A
G
Q
F
A
V
N
G
K
T
-
S
S
W
V
M
I
W
G
Y
-
A
S
Y
S
L
G
E
L
L
V
S
G
L
G
L
A
M
I
A
R
----
Y
F
M
M
G
A
Y
F
V
A
S
-
G
I
S
-
Q
Y
L
G
G
V
V
A
N
F
A
S
V
P
Q
D
L
V
----------------
5
PsiBlast_PDB
42.72
20%
-83
- C5 -
2GFP
-
EMRD_ECOLI
A:
[33-167]
------------------------------------------------------------
D
M
A
R
D
-
L
N
V
R
E
G
A
V
Q
S
V
M
------------
G
A
Y
L
L
T
Y
G
-----
V
S
Q
L
F
Y
G
P
I
S
D
R
V
-
G
R
R
P
V
I
L
-
V
G
---
M
S
I
F
M
L
A
T
-------------------
L
V
A
V
T
T
S
S
-
L
T
V
L
I
A
-
A
S
A
M
Q
G
M
-
G
T
-
G
----
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
-
T
Q
L
-----
R
--
H
A
--
N
S
L
L
N
M
G
I
L
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
W
----
N
-
W
R
A
C
Y
L
F
L
L
-
V
L
C
A
G
V
T
F
S
M
----------------------
A
---------------
R
W
M
P
----------------
E
-
T
R
P
V
------
D
A
P
R
-
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
-
F
---------
N
C
Y
L
L
M
-
L
I
G
G
L
--------------------------
A
G
I
A
A
F
E
A
C
S
G
------
V
L
M
G
A
V
----
L
G
L
-
S
S
M
T
V
S
---
I
-----
L
-
F
I
L
P
I
--
P
A
A
F
F
-
G
A
W
F
A
G
R
P
N
K
R
F
S
T
L
M
W
Q
S
V
I
---
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
G
-
V
M
N
V
W
T
L
L
V
P
A
A
L
-
F
F
--
F
G
A
G
M
L
F
P
L
--
A
T
S
G
A
M
E
P
-
F
P
F
L
A
G
----
T
A
G
A
L
V
G
G
L
-
Q
-
N
I
G
S
G
V
L
A
S
L
-
S
A
M
L
P
Q
T
G
Q
-
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
----
L
-------------------------------------------------