@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S22AV_HUMAN: (2015-12-09 )
MEQEARVLRAAGGFGRARRLLASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPALLDAAIPRLGPTRAPAEALGVLSPSYLAPLTRAPRPSSWASCSGAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHLPLLPPSNSYWAGHTPEQH
Atome Classification :
(20 SA)
---------.........10........20........30........40........50........-60........----70.-......---------.80........90.------.......100.........110......-.120.......130.......140-....---...150......----.--.160-..---..--....---170.----------------....---.----.-180.......-------190-..-...----...200...---....210........220......-..230----...--......-----------------------------240----------....---..---..250....-...260..--..---...270.--...-...280.....-----..290.-......300.......310.--......-.320....-...330.......340........350.......360.-----------.--.-.---..---.------370...----..---..---.-380..--------------.....390--.......400.-.--.-.---...410.....-----.--.420--.-.-----....-.-.----430.......440-.-------.-----------....--..-450.......460---..-.---....470.----------.-.-----..--..480.--......490-----.......500...-.-.----..510.......520.......530.......540-----.......550......----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------ME
Q
E
A
R
V
L
R
AAGG
F
G
R
A
R
R
L
L
ASAS
W
V
P
C
I
V
L
G
L
VLSSEELLTAQPAPHCRPDPTL
L
P
P
-
A
L
R
A
LRG
P
A
L
----
L
D
A
-AIPRLG---------PTRA
P
A
E
A
L
GVL
S
P
------
S
Y
LAPLTR--APRPSSWASCSGAAAG
P
T
-
W
N
L
V
CGDGWK
V
P
L
E
Q
V
S
H
L
L
G
W
L
L
-
G
C
V
I
---LGA
G
C
-
D
R
FG
R
R
----
A
--
V
F
V
--
A
S
---
L
V
--
L
TTG---LG
A
S
----------------
E
A
L
A
---
A
----
S
-
F
P
T
L
L
V
L
R
L
L-------HG--G
T
-
L
A
G
----
A
L
L
A
L
Y
L
A
R
---
L
ELCD-P
P
H
R
L
A
F
S
M
G
A
-
G
L
F
S
V
V
-
G
T
L
------
L
L
P
--
G
L
A
A
L
V
-----------------------------
Q
D
-----------
W
R
L
L
---
Q
G
---
L
G
A
L
M
S
G
L
L
-
L
L
F
WG
F
P
A
--LF---PESP
C
W
L
--
L
AT-
G
Q
V
A
R
A
R
K
I
L
W
-----
R
F
A
E
AS-GVGPGDSSLEENSLAT
A
-
T
E
--
L
T
M
LSA-RSPQPRYH-S
P
L
G
L
L
R
T
R
V
T
WRN-
G
L
I
L
G
F
S
S
L
VG
G
G
I
R
A
S
F
R
R
SLA-----------P--Q-V---
P
T
---
F
------
Y
-
L
P
Y
F
----
L
E
---A
G
---
L
-
E
A
A
A
L
--------------
V
F
L
L
LT
A
D
--CCGRR
P
V
L
L
L
G
-
T
--
M
-
V
---
T
G
L
A
S
L
L
L
L
AG-----A--QYL---P-
G
-----
W
T
V
L
-
F
-
L
----
S
V
L
G
L
L
A
S
R
A
V
S
--
A
-------
L
-----------
S
S
L
F
--
A
A
-
E
V
F
P
T
V
I
RGAG
L
G
---
L
V
-
L
---GA
G
F
LGQA----------A-G-----PL--DTLHGR--Q
G
F
F
L
Q
Q
V
V
-----
F
A
S
L
A
V
L
A
L
L
C
V
L
-L-L----PESRSRGL
P
Q
S
L
Q
D
A
D
R
L
R
RSPLLRGRPRQDHLPL-----LPPSNSYWAGHTPEQH----
2
PsiBlast_PDB
83.21
24%
-125
- C5 -
4GBZ
5
XYLE_ECOLI
A:
[65-473]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
-
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
----
D
S
L
K
I
A
--
A
V
---
L
F
--
F
I
S
G
---
V
G
S
A
W
PELGFTSINPDNTVP
V
Y
L
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
-------
G
G
I
-
G
V
G
L
A
S
----
M
L
S
P
M
Y
I
A
E
---
L
A
----
P
A
H
I
R
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
------
L
V
Y
--
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
T
------------------
D
G
-----------
W
R
Y
M
F
A
S
E
C
---
I
P
A
L
L
F
-
L
M
-
L
L
Y
-------
T
V
---
P
E
S
P
R
W
L
--
M
S
R
-
G
K
Q
E
Q
A
E
G
I
L
-------------------
R
K
I
M
G
N
T
L
A
T
-------------
Q
A
V
Q
E
I
K
H
-
S
---
L
D
H
G
R
K
T
G
G
R
-
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
-----------
I
--
N
-
V
---
V
L
---
Y
------
Y
-
A
P
E
V
----
F
K
T
L
G
A
S
---
T
-
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
-
V
L
A
I
M
T
V
D
--
K
F
G
R
K
P
L
Q
I
I
G
-
A
--
L
------
G
M
A
I
G
M
F
S
L
G
-----
T
--
A
F
Y
T
QA
P
-
G
------
I
V
A
-
L
-
L
----
S
M
L
F
Y
V
A
A
F
A
M
S
WG
P
-------
V
-----------
C
W
V
L
--
L
S
-
E
I
F
P
N
A
I
R
G
K
A
L
A
---
I
A
-
V
---
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
-
N
-----
S
W
--
L
V
A
H
F
H
--
N
G
F
--
S
Y
W
I
-----
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
-
V
----
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------------
3
PsiBlast_PDB
82.96
24%
-124
- C5 -
4GC0
5
XYLE_ECOLI
A:
[65-473]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
-
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
----
D
S
L
K
I
A
--
A
V
---
L
F
--
F
I
S
G
---
V
G
S
A
WPELGFTSINPDNTVP
V
Y
L
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
-------
G
G
I
-
G
V
G
L
A
S
----
M
L
S
P
M
Y
I
A
E
---
L
A
----
P
A
H
I
R
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
------
L
V
Y
--
C
V
N
Y
F
I
A
R
S
GD
A
S
W
L
N
T
------------------
D
G
-----------
W
R
Y
M
F
A
S
E
C
---
I
P
A
L
L
F
-
L
M
-
L
L
Y
-------
T
V
---
P
E
S
P
R
W
L
--
M
S
R
-
G
K
Q
E
Q
A
E
G
I
L
-------------------
R
K
I
M
G
N
T
L
A
T
-------------
Q
A
V
Q
E
I
K
H
-
S
---
L
D
H
G
R
K
T
G
G
R
-
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
-----------
I
--
N
-
V
---
V
L
---
Y
------
Y
-
A
P
E
V
----
F
K
T
L
G
A
S
---
T
-
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
-
V
L
A
I
M
T
V
D
--
K
F
G
R
K
P
L
Q
I
I
G
-
A
--
L
------
G
M
A
I
G
M
F
S
L
G
-----
T
--
A
F
Y
T
QA
P
-
G
------
I
V
A
-
L
-
L
----
S
M
L
F
Y
V
A
A
F
A
M
S
WG
P
-------
V
-----------
C
W
V
L
--
L
S
-
E
I
F
P
N
A
I
R
G
K
A
L
A
---
I
A
-
V
---
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
-
N
-----
S
W
--
L
V
A
H
F
H
--
N
G
F
--
S
Y
W
I
-----
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
-
V
----
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------------
1
PsiBlast_PDB
82.17
24%
-128
- C5 -
4GBY
5
XYLE_ECOLI
A:
[65-473]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
-
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
----
D
S
L
K
I
A
--
A
V
---
L
F
--
F
I
S
G
---
V
G
S
A
WPELGFTSINPDNTVP
V
Y
L
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
-------
G
G
I
-
G
V
G
L
A
S
----
M
L
S
P
M
Y
I
A
E
---
L
A
----
P
A
H
I
R
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
------
L
V
Y
--
C
V
N
Y
F
I
A
R
SGD
A
S
W
L
N
T
------------------
D
G
-----------
W
R
Y
M
F
A
S
E
C
---
I
P
A
L
L
F
-
L
M
-
L
L
Y
-------
T
V
---
P
E
S
P
R
W
L
--
M
S
R
-
G
K
Q
E
Q
A
E
G
I
L
-------------------
R
K
I
M
G
N
T
L
A
T
-------------
Q
A
V
Q
E
I
K
H
-
S
---
L
D
H
G
R
K
T
G
G
R
-
L
L
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
-----------
I
--
N
-
V
---
V
L
---
Y
------
Y
-
A
P
E
V
----
F
K
T
LG
A
S
---
T
-
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
-
V
L
A
I
M
T
V
D
--
K
F
G
R
K
P
L
Q
I
I
G
-
A
--
L
------
G
M
A
I
G
M
F
S
L
G
-----
T
--
A
F
Y
T
QA
P
-
G
------
I
V
A
-
L
-
L
----
S
M
L
F
Y
V
A
A
F
A
M
S
WG
P
-------
V
-----------
C
W
V
L
--
L
S
-
E
I
F
P
N
A
I
R
G
K
A
L
A
---
I
A
-
V
---
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
-
N
-----
S
W
--
L
V
A
H
F
H
--
N
G
F
--
S
Y
W
I
-----
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
-
V
----
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------------
19
Fugue
81.88
17%
-112
- C5 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
----------
Y
N
S
S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
------------------------------
T
V
E
S
L
N
T
V
F
V
----
A
P
Q
-
N
L
S
E
S
A
---------
A
N
S
L
L
G
F
C
V
A
-------------------------------------------------------
S
A
L
I
G
C
I
I
-
G
G
A
L
---
G
G
Y
C
S
-
N
R
F
G
R
R
----
D
--
S
L
K
I
A
A
V
---
L
F
--
F
I
S
G
---
V
G
S
A
WPELGFTSINPDNTVP
V
Y
L
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
-------
G
G
--
I
G
-
V
G
L
----
A
S
M
L
S
P
M
Y
I
---
A
E
L
A
P
-
A
H
I
R
G
K
L
V
S
F
N
-
Q
F
A
I
I
F
-
G
Q
L
------
L
V
Y
--
C
V
N
Y
F
I
-----------------------------
A
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
M
---
F
A
---
S
E
C
I
P
A
L
L
F
-
L
M
L
L
Y
T
-----
V
---
P
E
S
P
R
W
L
--
M
S
R
-
G
K
Q
E
Q
A
E
G
I
L
R
-----
K
I
M
--------
G
N
T
L
A
T
Q
A
V
Q
E
I
K
-
H
S
--
L
D
H
G
R
K
-
T
G
G
R
L
L
M
F
-
G
V
G
V
I
V
I
G
V
M
L
S
I
F
-
Q
Q
F
V
G
I
N
V
V
L
Y
--
Y
A
P
E
V
F
K
T
L
G
-----------
A
--
S
-
T
---
D
I
---
A
------
L
-
L
Q
T
I
----
I
V
---
G
V
---
I
-
N
L
T
F
T
--------------
V
L
A
I
M
T
V
D
--
K
F
G
R
K
P
L
Q
I
I
G
-
A
--
L
-
G
---
M
A
I
G
M
F
S
L
G
T
A
-----
F
--
Y
T
Q
---
A
-
P
-----
G
I
V
A
-
L
-
L
----
S
M
L
F
Y
V
A
A
F
A
M
S
WG
P
-------
V
-----------
C
W
V
L
--
L
S
-
E
I
F
P
N
A
I
R
G
K
A
L
A
---
I
A
-
V
---
A
A
Q
W
L
A
N
Y
----------
F
-
V
S
W
T
F
P
M
M
--
D
K
N
S
W
L
--
V
A
H
F
H
N
G
F
S
-----
Y
W
I
Y
G
C
M
G
V
L
A
A
L
-
F
-
M
----
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
----------------------------------------
5
PsiBlast_PDB
78.84
26%
-129
- C5 -
4LDS
-
?
A:
[50-427]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
L
I
G
A
I
V
-
G
A
G
S
---
S
G
P
L
A
-
D
K
L
G
R
R
R
---
L
--
V
M
L
--
I
A
---
I
V
--
F
I
I
G
A
L
I
L
A
A
S
----------------
T
N
L
A
---
L
----
L
-
I
I
G
R
L
I
I
G
L
A
-------
V
G
--
G
S
-
M
S
T
------
V
P
V
Y
L
S
-----
E
M
A
P
-
T
E
Y
R
G
S
L
G
S
L
N
-
Q
L
M
I
T
I
-
G
I
L
A
A
Y---
L
V
N
--
Y
A
F
A
D
I
-----------------------------
E
G
-----------
W
R
W
M
---
L
G
---
L
A
V
V
P
S
V
I
L
-
L
V
G
I
Y
F
-----
M
---
P
E
S
P
R
W
L
--
L
E
N
-
R
N
E
E
A
A
R
Q
V
M
-------------
K
I
T
Y
D
D
S
E
I
D
K
E
-
L
K
E
M
-
K
E
--
I
N
A
I
S
--
E
S
T
W
T
V
I
K
-
S
P
---------
W
L
G
-
R
I
------
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
-----------
I
--
N
-
A
---
V
I
---
F
------
Y
S
S
S
I
F
----
A
K
---
A
G
---
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
--
K
I
D
R
K
K
-
L
L
V
G
-
G
--
N
-
I
---
G
M
I
A
S
L
L
I
M
A
I
-----
L
--
I
W
T
---
I
-
G
IA
S
S
A
W
I
I
I
-
V
C
L
----
S
L
F
I
V
F
F
G
I
S
W
G
--
P
-------
V
-----------
L
W
V
M
--
L
P
-
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
-
L
---
N
I
G
T
L
I
V
S
----------
L
F
F
-----
P
I
LS
D
A
L
S
T
E
--
W
V
F
----
L
I
-----
F
A
F
I
G
V
L
A
M
I
F
V
I
K
F
-
L
----
P
E
T
R
G
-------------------------------------------------------
13
PsiBlast_PDB
76.54
24%
-123
- C5 -
4PYP
1
GTR1_HUMAN
A:
[74-455]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
G
M
I
-
G
S
F
S
---
V
G
L
F
V
-
N
R
F
G
R
R
N
---
S
--
M
L
M
--
M
N
---
L
L
A
F
V
S
A
V
---
L
M
G
F
----------------
S
K
L
G
---
K
----
S
-
F
E
M
L
I
L
G
R
F
I
-------
I
G
V
Y
C
G
-
L
T
T
----
G
F
V
P
M
Y
V
G
-----
E
V
S
P
-
T
A
L
R
G
A
L
G
T
L
H
-
Q
L
G
I
V
V
-
G
I
L
------
I
A
Q
V
F
G
L
D
S
I
M
-----------------------------
G
N
KDL--------
W
P
L
L
---
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
-
L
P
F
C
-----------
P
E
S
P
R
F
L
--
L
I
N
R
N
E
E
N
R
A
K
S
V
L
K
-----
K
L
R
G
T
A
-
D
V
T
H
D
L
Q
E
M
K
E
E
S
R
Q
M
M
-
R
E
KK
V
T
I
L
E
L
F
R
S
P
A
--
Y
R
-
Q
P
I
L
I
----------
A
V
V
L
Q
L
S
Q
Q
L
-
S
G
I
N
A
V
F
Y
Y
S
T
S
-----------
I
F
-
E
-
K
---
A
G
---
V
------
Q
-
Q
P
V
Y
----
A
T
---
I
G
S
G
I
V
-
N
T
A
F
T
--------------
V
V
S
L
F
V
V
Q
--
R
A
G
R
R
T
L
H
L
I
G
-
L
--
A
G
M
---
A
G
C
A
I
L
M
T
I
A
L
-----
A
LL
E
Q
L
---
P
-
W
-----
M
S
Y
L
S
I
-
V
----
A
I
F
G
F
V
A
F
F
E
V
G
--
P
GP
I
P
W
F
I
V
-----------
A
E
L
F
--
S
Q
-
G
P
R
P
A
A
I
A
V
A
G
F
S
---
N
W
-
T
---
S
N
F
I
V
G
M
C
----------
F
-
Q
-----
Y
V
--
E
Q
L
C
G
P
--
Y
V
F
----
I
I
-----
F
T
V
L
L
V
L
F
F
I
F
T
Y
-
F
K
V
----
P
E
T
---------------------------------------------------------
20
Fugue
75.60
20%
-103
- C5 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
-------S
Y
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
---
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
S
-
E
S
A
A
N
S
L
L
G
F
C
V
A
S
A
-
L
I
G
C
I
I
G
G
A
L
----
G
G
Y
-
C
S
N
R
F
G
---------
R
R
D
S
L
K
I
A
A
V
L
F
F
I
------
S
G
V
G
S
A
W
P
--
E
L
G
F
T
S
I
N
P
D
N
-----------------
T
V
P
--------------------------------------------------------------------------------
V
Y
L
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
G
G
-----
I
G
--
V
G
-
L
A
S
----
M
L
S
P
M
Y
I
A
E
---
L
A
----
P
A
H
I
R
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
------
L
V
Y
--
C
V
N
Y
F
I
A
R
SGD------------------------
A
S
-----------
W
L
N
T
---
D
G
---
W
R
Y
M
F
A
S
E
C
-
I
P
A
L
L
F
L
M
--
L
L
Y
T
V
P
E
S
P
R
W
L
MT
L
A
T
-
Q
A
V
Q
E
I
K
H
S
L
-------------------
D
R
L
L
M
F
G
V
G
V
I
-
V
I
--
G
V
M
L
S
I
-
F
Q
Q
F
V
G
I
N
-
V
V
L
Y
Y
A
P
E
V
F
------------------------
K
T
L
G
-----------
A
--
S
-
T
---
D
I
---
A
------
L
-
L
Q
T
I
----
I
V
---
G
V
---
I
-
N
L
T
F
T
--------------
V
L
A
I
M
T
V
D
--
K
F
G
R
K
P
L
Q
I
I
G
-
A
--
L
-
G
---
M
A
I
G
M
F
S
L
G
T
A
-----
F
--
Y
T
Q
---
A
-
P
-----
G
I
V
A
-
L
-
L
----
S
M
L
F
Y
V
A
A
F
A
M
S
WG
P
-------
V
-----------
C
W
V
L
--
L
S
-
E
I
F
P
N
A
I
R
G
K
A
L
A
---
I
A
-
V
---
A
A
Q
W
L
A
N
Y
----------
F
-
V
-----
S
W
--
T
F
P
M
M
D
--
K
N
S
W
L
V
A
H
F
HNGF
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
-
F
-
M
W
KFV
P
E
T
K
G
K
T
L
----------------------------------------------------
4
PsiBlast_PDB
71.56
25%
-135
- C5 -
4JA4
-
XYLE_ECOLI
A:
[65-473]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
-
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
----
D
S
L
K
I
A
--
A
V
---
L
F
--
F
I
S
G
---
V
G
S
A
W
PELGF
T
S
I
N
P
D
N
T
V
P
V
Y
L
A
---
G
----
Y
-
V
P
E
F
V
I
Y
R
I
I
-------
G
G
I
-
G
V
G
L
A
S
----
M
L
S
P
M
Y
I
A
E
---
L
A
----
P
A
H
I
R
G
K
L
V
S
F
-
N
Q
F
A
I
I
F
G
Q
L
------
L
V
Y
--
C
V
N
Y
F
I
A
RSGD
A
S
W
L
N
T
------------------
D
G
-----------
W
R
Y
M
F
A
S
E
C
---
I
P
A
L
L
F
-
L
M
-
L
L
Y
-------
T
V
---
P
E
S
P
R
W
L
--
M
-----
Q
E
Q
A
E
G
I
L
-------------------
R
K
I
M
G
N
T
L
A
T
-------------
Q
A
V
Q
E
I
K
H
-
S
---
L
D
H
G
---------
M
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
-----------
I
--
N
-
V
---
V
L
---
Y
------
Y
-
A
P
E
V
-------------------
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
-
V
L
A
I
M
T
V
D
--
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
-
A
---
I
G
M
F
S
L
G
T
A
F
Y
-----
T
--
Q
-
A
---
P
-
G
------
I
V
A
-
L
-
L
----
S
M
L
F
Y
V
A
A
F
A
M
S
WG
P
-------
V
-----------
C
W
V
L
--
L
S
-
E
I
F
P
N
A
I
R
G
K
A
L
A
---
I
A
-
V
---
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
M
D
K
-
N
-----
S
W
----------
N
G
F
--
S
Y
W
I
-----
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
-
V
----
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
--------------------------------------------
26
Fugue
67.88
15%
-96
- C2 -
3ZHE
-
?
A:
[2-400]
-------------
Q
K
S
D
E
V
T
E
K
F
K
R
Y
C
N
Q
L
E
K
Y
G
--------------------------
Q
T
E
N
V
H
S
P
-
V
M
A
M
L
R
R
K
G
R
K
Q
--
L
I
E
-
I
M
K
R
D
G
---------
D
C
T
S
S
I
N
K
L
W
I
V
G
--------
Y
Y
H
P
F
Q
F
--
F
I
R
D
K
E
--------------------------------------------------------------------------------
K
N
---
M
A
I
A
----------------
V
L
L
T
---
M
----
F
-
C
G
E
L
Q
E
M
L
S
L
-------
P
D
--
D
K
-
Y
-
P
----
A
L
W
N
M
Y
I
G
D
---
F
H
R
Y
M
-
P
D
E
E
I
Q
K
C
L
A
V
-
G
Y
Y
S
R
A
-
I
D
L
DPNQ
G
R
A
F
H
--
V
L
A
G
L
R
-----------------------------
A
D
-----------
L
N
V
A
---
Q
K
---
L
R
L
M
I
L
G
Q
L
-
A
---
D
A
P
Y
--
K
K
---
G
T
E
L
L
E
Y
--
L
K
F
-
P
Q
K
E
S
T
D
K
L
M
V
-----
D
F
V
I
W
A
L
N
E
K
S
K
R
M
D
Y
Q
M
T
G
I
K
I
V
-
N
E
--
F
K
A
E
I
E
-
Q
K
L
E
F
D
W
S
-
L
I
M
S
T
C
R
L
A
S
K
L
A
M
-
K
K
F
-----------
G
F
Q
Q
F
Y
N
C
F
-----------
D
--
T
-
I
---
S
T
---
L
------
Y
-
I
T
I
Y
S
R
TI
S
S
---
K
C
---
L
-
L
A
E
A
I
--------------
S
W
I
S
D
S
A
E
--
I
L
G
H
L
D
E
Q
K
----------------------
N
-----
E
--
P
H
F
---
Q
-
K
-----
L
S
V
F
-
A
-
K
----
T
K
W
N
E
L
N
D
L
V
M
N
--
H
-------
I
-----------
N
S
V
F
--
T
S
-
M
S
L
T
I
-------------------------
N
----------
P
-
S
-----
I
S
--
M
T
S
F
L
L
--
N
G
P
---------------------------
I
----
S
E
P
N
V
E
F
L
S
Q
L
I
N
Y
L
V
S
V
E
F
P
P
M
E
I
I
H
D
R
E
E
S
G
P
L
-----
L
R
R
I
N
---------------
23
Fugue
66.53
14%
-90
* C6 *
3J16
3
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
A
D
K
C
K
P
K
K
C
R
Q
E
C
K
R
S
C
P
V
V
K
T
G
K
L
C
I
E
V
T
P
T
-
S
K
I
A
F
I
S
E
I
L
C
I
G
C
G
I
C
V
K
K
C
P
F
D
A
I
Q
I
I
N
L
P
T
N
----
L
E
A
H
V
T
H
R
Y
S
AN
S
F
K
L
H
R
L
P
T
P
R
P
G
Q
V
L
G
L
V
G
T
N
GIG
K
S
T
A
L
K
I
L
A
G
--
K
Q
K
P
N
L
G
R
F
D
D
P
P
E
W
Q
E
I
-
I
K
Y
F
R
G
S
E
L
Q
N
Y
F
T
K
M
L
E
---
D
D
I
-
K
A
I
I
---
K
P
Q
Y
V
-
D
N
I
P
R
A
I
KGP
V
--
Q
K
V
--
G
E
---
L
L
--
K
L
R
M
---
E
K
S
P
----------------
E
D
V
K
---
R
----
Y
-
I
K
I
L
Q
L
E
N
V
L
KRDIEKL
S
G
--
G
E
-
L
Q
R
----
F
A
I
G
M
S
C
V
Q
EAD
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
-
N
A
A
Q
I
I
-
R
S
L
------
L
A
P
--
T
K
Y
V
I
C
V
E
---------------------------
H
D
-----------
L
S
V
L
---
D
Y
---
L
----
S
D
F
V
-
C
I
I
Y
G
V
P
S
V
Y
G
V
---
V
T
L
P
A
S
V
--
R
E
G
-
I
N
I
F
L
D
G
H
I
P
A
-----
E
N
L
R
F
R
-
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
L
Q
N
-
D
S
--
A
S
R
A
F
S
-
Y
P
S
L
K
K
T
Q
-
G
D
F
V
L
N
V
E
E
G
E
F
S
D
-
S
E
I
L
V
M
M
G
E
N
G
T
G
-
K
T
T
L
I
K
L
L
A
GALKPD
E
G
Q
D
I
P
--
K
-
L
---
N
V
---
S
------
M
-
K
P
Q
K
----
I
A
---
P
K
---
F
-
P
G
T
V
R
--------------
Q
L
F
F
K
K
I
R
--
G
Q
F
L
N
P
Q
F
Q
T
D
-
V
--
V
-
K
---
P
L
R
I
D
D
I
I
D
Q
E
-----
V
--
Q
H
L
---
S
-
G
-----
G
E
L
Q
-
R
-
V
----
A
I
V
L
A
L
G
I
P
A
D
I
--
Y
-------
L
I
D
EPSAYLD
S
E
Q
R
I
I
--
C
S
-
K
V
I
R
R
F
I
L
H
N
K
K
T
---
A
F
-
I
V
E
H
D
F
I
M
A
T
Y
L
----------
A
-
D
-----
K
V
--
I
V
F
E
G
I
--
P
S
--------------------
K
N
A
H
A
-
R
-
A
----
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
R
D
P
N
S
F
R
P
R
I
N
K
L
D
S
-----
Q
M
D
K
E
Q
K
S
S
G
N
Y
F
F
L
D
NTGI
29
HHSearch
63.41
16%
-120
* C5 *
3WDO
-
?
A:
[40-388]
-----------------------------------------------------------------------------------------------------------------------------------------------------
L
-
Q
G
A
S
---
E
A
L
I
G
I
A
I
G
I
Y
G
L
T
Q
A
V
-
F
Q
I
P
---
F
G
L
L
S
-
D
R
I
G
R
K
----
P
--
L
I
V
--
G
G
---
L
A
--
V
F
A
A
---
G
S
V
I
----------------
A
A
L
S
---
D
----
S
-
I
W
G
I
I
L
G
R
A
L
-------
Q
G
--
S
G
-
A
------
I
A
A
A
V
M
A
L
L
---
S
D
L
T
R
-
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
F
G
I
-
T
F
A
------
I
A
M
--
V
L
G
P
I
I
T
H
K
--------------------------
L
G
-----------
L
H
A
L
---
F
W
---
M
I
A
I
L
A
T
T
G
I
A
L
T
I
---
W
--
V
V
---
P
N
S
S
T
H
V
--
L
N
R
-
E
-----------------------------------------------------
S
G
M
V
K
G
-
S
F
S
K
V
L
A
E
P
R
L
L
K
L
-
N
F
G
I
M
C
L
H
M
L
L
M
S
T
F
V
A
L
P
G
Q
L
A
-----------
D
--
A
-
G
---
F
P
---
A
A
E
H
W
K
V
Y
-
L
A
T
M
----
L
I
---
A
F
---
G
-
S
V
V
P
F
--------------
I
I
Y
A
E
V
K
R
--
K
M
K
Q
--
V
F
V
F
C
-
V
--
G
-
L
---
I
V
V
A
E
I
V
L
W
N
A
---------
Q
T
---
Q
-
F
-----
W
Q
L
V
-
V
-
G
----
V
Q
L
F
F
V
A
F
N
L
M
E
--
A
-------
L
-----------
L
P
S
L
--
I
S
-
K
E
S
P
A
G
Y
K
G
T
A
M
G
---
V
Y
-
S
---
T
S
Q
F
L
G
V
A
----------
I
-
G
-----
G
S
--
L
G
G
W
I
D
G
M
F
D
G
Q
G
V
F
L
A
-----
G
A
M
L
A
A
V
W
L
A
V
A
S
-
T
-
M
----
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
-----
V
L
I
A
E
E
E
H
S
A
Y
V
K
I
D
S
----
21
Fugue
56.95
14%
-84
- C5 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
---------------------------------------------------------------
L
L
L
M
L
-
V
L
L
V
A
V
G
Q
M
A
----
Q
T
I
-
Y
I
P
A
I
A
---------
D
M
A
R
D
L
N
V
-----------------------------------------------
R
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
-
S
Q
L
F
---
Y
G
P
I
S
-
D
R
V
G
R
R
----
P
--
V
I
L
--
V
G
---
M
S
--
I
F
M
L
---
A
T
L
V
----------------
A
V
T
T
---
S
----
S
-
L
T
V
L
I
A
A
S
A
M
-------
Q
G
--
M
G
-
T
G
V
----
G
G
V
M
A
R
T
L
P
---
R
D
L
Y
E
-
R
T
Q
L
R
H
---------------------------
A
N
S
L
L
N
-----------------------------
M
G
-----------
I
L
V
S
---
P
L
---
L
A
P
L
I
G
G
L
L
-
D
T
M
W
N
W
R
A
--
C
Y
--------
L
F
--
L
L
V
-
L
C
A
G
V
T
F
S
M
A
R
-----
W
M
P
E
T
R
-
P
V
D
A
P
R
T
R
-------------------------------------------------------------
L
L
T
S
Y
K
T
-----------
L
--
F
-
G
---
N
S
---
G
------
F
-
N
C
Y
L
----
L
M
---
L
I
---
G
-
G
L
A
G
I
--------------
A
A
F
E
A
C
S
--------
G
V
L
M
G
A
-
V
--
L
-
G
---
L
S
S
M
T
V
S
I
L
F
I
-----------------------------
L
----
P
I
P
A
A
F
F
G
A
W
F
A
--
G
R------
P
-----------
N
K
R
F
--
S
T
-
L
M
W
Q
S
V
I
C
C
L
L
A
G
---
L
L
-
M
---
W
I
P
D
W
F
G
V
----------
M
-
N
-----
V
W
--
T
L
L
V
P
A
--
A
L
F
F
F
G
A
G
M
-----
L
F
P
L
A
T
S
G
A
M
E
P
F
-
P
-
F
----
L
A
G
T
A
G
A
L
V
G
G
L
Q
N
I
G
S
G
V
L
A
S
L
S
A
M
L
P
Q
T
G
Q
G
S
L
-----
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L--
22
Fugue
56.79
18%
-105
* C4 *
2GOP
-
?
A:
[10-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
A
K
F
A
Y
L
-------
S
D
--
P
R
-
T
K
G
----
E
L
V
A
Y
V
L
T
K
---
A
N
L
K
D
-
N
K
Y
E
N
T
I
V
I
E
N
-
L
K
N
N
A
R
-
R
F
I
------
E
N
A
--
T
M
P
R
I
S
-----------------------------
P
D
-----------
G
K
K
I
---
A
F
---
M
R
A
N
E
E
K
K
V
-
S
E
I
W
V
A
D
L
--
E
T
---
L
S
S
K
K
I
L
--
E
A
K
-----
N
I
R
S
L
E
W
N
EDSR
K
L
L
I
V
G
-
F
K
R
R
E
V
P
A
W
E
K
T
T
F
W
I
F
D
T
E
--
S
E
E
V
I
E
-
E
F
E
K
P
R
F
---------
S
S
G
I
W
H
R
-
D
K
I
V
V
N
V
P
----------
H
R
E
I
I
-----------
P
--
Q
-
Y
---
F
K
---
F
------
W
-
D
I
Y
I
----
W
E
---
D
G
---
K
-
E
E
K
M
F
--------------
E
K
V
S
F
Y
A
V
--
D
S
D
G
E
R
I
L
L
Y
G
-
K
-----------------
P
E
-----
K
--
K
Y
M
---
S
-
E
-----
H
N
K
L
-
Y
-
I
Y
DG
K
E
V
M
G
I
L
D
E
V
D
R
G
--
V
-------
G
-----------
Q
A
K
I
--
K
D
G
K
V
Y
F
T
L
F
E
E
G
S
V
N
---
L
Y
-
I
---
W
D
G
E
I
K
P
I
----------
A
-----------
K
G
R
H
W
I
--
M
G
F
D
V
D
E
I
-----------------
V
V
-
Y
-
L
----
K
E
T
A
T
R
--
L
R
E
L
F
T
W
D
G
E
E
K
Q
L
T
D
Y
N
D
P
I
F
A
K
L
---------------------------
27
Fugue
55.53
12%
-84
- C1 -
1DQU
-
ACEA_EMENI
A:
[2-520]
---------
S
Y
I
E
E
E
D
Q
R
Y
W
D
E
V
A
A
V
K
N
W
W
K
-
D
S
R
W
R
Y
T
--------
K
R
P
F
T
A
E
Q
I
V
A
K
R
G
N
L
K
--
I
E
-
Y
P
-
S
N
V
Q
A
K
K
----
L
W
G
-
I
L
E
R
N
F
---------
K
N
K
E
A
S
F
T
Y
G
C
L
D
P
------
T
M
V
T
Q
M
A
K
--
Y
-
L
D
T
V
Y
V
S
G
W
Q
S
S
S
T
A
S
S
T
D
E
P
S
P
D
L
A
D
Y
P
M
N
T
V
P
N
K
V
N
H
L
W
-
M
A
Q
L
---
F
H
D
R
K
-
Q
R
E
E
R
M
-----------------------
T
T
---
P
K
D
Q
----------------
R
H
K
V
---
A
----
N
-
V
-
D
Y
L
R
P
I
I
A
-------
D
A
--
D
T
-
G
H
G
----
G
L
T
A
V
M
K
L
T
---
K
L
F
V
E
-
R
--------
G
A
-
A
G
I
H
I
E
-
D
Q
A
------
P
G
T
--
K
-----------------------------------------------
G
K
V
L
---
V
P
---
I
S
E
H
I
N
R
L
V
-
A
I
R
A
Q
A
D
I
--
M
G
---
T
D
L
--
L
A
--
I
A
R
-
T
D
S
E
A
A
T
L
I
-----------
T
S
-
T
I
D
H
R
D
H
P
F
I
I
G
S
T
N
P
D
-
I
Q
--
P
L
N
D
L
M
-
V
M
A
E
Q
A
G
K
-
N
G
A
E
L
Q
A
I
E
D
E
W
L
A
K
A
G
L
K
L
F
N
D
A
V
V
D
A
I
N
N
S
P
L
P
N
K
K
-----------
A
--
A
-
I
---
E
K
---
Y
------
L
-
T
Q
S
K
----
G
K
---
S
N
---
L
-
E
A
R
A
I
--------------
A
K
E
I
A
G
T
D
I
Y
F
D
W
E
A
P
R
T
R
E
G
Y
Y
--
R
-
Y
---
Q
G
G
T
Q
C
A
I
N
R
A
-----
V
--
A
Y
A
---
P
-
F
-----
A
D
L
I
-
W
-
M
----
E
S
K
L
P
D
Y
K
Q
A
K
E
--
F
-------
A
-----------
D
G
V
H
--
A
V
-
W
P
E
Q
K
L
A
Y
N
L
S
P
S
---
F
N
-
W
---
K
K
A
M
P
R
D
E
----------
Q
-
E
-----
T
Y
--
I
K
R
L
G
A
--
L
G
Y
A
W
Q
F
I
T
-----
L
A
G
L
H
T
T
A
L
I
S
D
T
-
F
-
A
----
K
A
Y
A
K
Q
G
M
R
A
Y
G
E
L
V
Q
E
P
E
M
A
N
---
G
V
D
V
V
T
H
Q
K
W
SG
A
N
Y
V
D
N
M
L
K
M
I
T
G
G
---------
30
HHSearch
55.46
16%
-105
- C5 -
1PW4
-
GLPT_ECOLI
A:
[57-429]
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
-
Q
G
F
S
---
R
G
D
L
G
F
A
L
S
G
I
S
I
A
Y
G
F
-
S
K
F
I
---
M
G
S
V
S
-
D
R
S
N
P
R
----
V
--
F
L
P
--
A
G
---
L
I
--
L
A
A
A
---
V
M
L
F
----------------
M
G
F
V
---
P
W
A
T
S
S
-
I
A
V
M
F
V
L
L
F
L
-------
C
G
--
W
F
-
Q
G
M
----
G
W
P
P
C
G
R
T
M
---
V
H
W
W
S
-
Q
K
E
R
G
G
I
V
S
V
W
-
N
C
A
H
N
V
-
G
G
G
------
I
P
P
--
L
L
F
L
L
G
M
AWF-------------------------
N
D
-----------
W
H
A
A
---
L
Y
---
M
P
A
F
C
A
I
L
V
A
L
F
A
F
---
A
--
M
M
---
R
D
T
P
Q
S
C
--
G
L
P
-
P
I
-
E
E
Y
K
N
--------
D
---------------------------------------
T
A
K
Q
I
F
M
Q
Y
V
L
P
N
K
L
L
W
Y
I
-
A
I
A
N
V
F
V
Y
L
L
R
Y
G
I
L
D
W
S
P
T
Y
L
K
-----------
E
--
V
K
H
FA
L
D
K
---
S
------
S
-
W
A
Y
F
----
L
Y
---
E
Y
---
A
-
G
I
P
G
T
--------------
L
L
C
G
W
M
S
D
--
K
V
F
R
G
N
R
G
A
T
G
-
V
--
F
-
F
M
T
L
V
T
I
A
T
I
V
Y
W
M
N
--------
P
A
G
---
N
-
P
-----
T
V
D
M
-
I
-
C
----
M
I
V
I
G
F
L
I
Y
G
P
V
--
M
-------
L
-----------
I
G
L
H
--
A
L
-
E
L
A
P
K
K
A
A
G
T
A
A
G
---
F
T
-
G
---
L
F
G
Y
L
G
G
S
V
---------
A
-
A
-----
S
A
--
I
V
G
Y
T
V
D
F
F
G
W
D
G
G
F
M
V
-----
M
I
G
G
S
I
L
A
V
I
L
L
I
-
V
-
V
----
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-------------------------------------------
31
HHSearch
52.24
11%
-92
- C5 -
3O7Q
1
FUCP_ECOLI
A:
[50-405]
------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
F
Q
Q
A
-
F
T
L
T
---
N
F
Q
A
G
L
I
Q
S
A
F
Y
F
G
Y
F
I
-
I
P
I
P
---
A
G
I
L
M
-
K
K
L
S
Y
K
----
A
--
G
I
I
--
T
G
---
L
F
--
L
Y
A
L
---
G
A
A
L
----------------
F
W
P
A
A
E
I
M
----
N
-
Y
T
L
F
L
V
G
L
F
I
-------
I
A
--
A
G
-
L
G
C
----
L
E
T
A
A
N
P
F
V
---
T
V
L
G
P
-
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
N
S
F
-
G
A
I
------
I
A
V
--
V
F
G
Q
S
L
ILSNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-----------
V
Q
T
P
---
Y
M
---
I
I
V
A
I
V
L
L
V
A
L
L
I
M
L
--
T
--
K
F
---
P
A
L
Q
S
D
-----
N
--
H
S
D
A
------------------------------------------------
K
Q
G
S
F
S
A
-
S
L
S
R
L
A
R
I
R
H
W
R
W
A
-
V
L
A
Q
F
C
Y
V
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
A
V
E
----------
E
I-
P
-
G
---
M
T
A
G
F
A
------
A
-
N
Y
L
T
----
G
T
---
M
V
---
C
-
F
F
I
G
R
--------------
F
T
G
T
W
L
I
S
--
R
F
A
P
H
K
V
L
A
A
Y
-
A
--
L
-
I
---
A
M
A
L
C
L
I
S
A
F
A
----------
G
---
G
-
H
-----
V
G
L
--
I
-
A
----
L
T
L
C
S
A
F
M
S
I
Q
Y
--
P
-------
T
-----------
I
F
S
L
--
G
I
-
K
N
L
G
Q
D
T
K
-
Y
G
S
S
---
F
I
-----
V
M
T
I
I
G
G
G
----------
I
-
V
-----
T
P
--
V
M
G
F
V
S
--
D
A
A
G
N
I
P
T
A
-----
E
L
I
P
A
L
C
F
A
V
I
F
I
-
F
-
A
----
R
F
R
S
Q
T
------------------------------------------------------
6
PsiBlast_PDB
50.76
26%
-85
- C5 -
4J05
-
?
A:
[377-518]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
L
F
L
I
D
--
I
V
G
R
K
K
L
Q
F
M
G
-
F
--
I
-
M
---
S
G
L
F
-
L
A
I
L
A
G
-----
E
--
I
D
H
---
I
-
G
-----
K
G
P
L
-
L
-
A
----
C
F
T
F
M
Q
F
F
F
N
F
G
--
A
-------
N
-----------
T
T
T
F
I
V
A
A
-
E
L
F
P
T
R
I
R
A
S
A
H
G
---
I
S
-
A
---
A
A
G
K
C
G
A
I
----------
L
-
S
-----
S
L
V
F
N
Q
L
K
A
K
--
I
G
T
S
A
V
L
W
I
-----
F
F
S
T
C
I
L
G
F
I
S
T
F
-
L
-
I
----
D
E
--
T
M
G
V
D
P
D
E
K
D
L
E
E
R
R
A
R
---------------------------------------
32
HHSearch
50.62
14%
-97
- C5 -
2GFP
-
EMRD_ECOLI
A:
[33-358]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
M
A
R
D
-
L
N
V
R
---
E
G
A
V
Q
S
V
M
G
A
Y
L
L
T
Y
G
V
-
S
Q
L
F
---
Y
G
P
I
S
-
D
R
V
G
R
R
----
P
--
V
I
L
--
V
G
---
M
S
--
I
F
M
L
---
A
T
L
V
----------------
A
V
T
T
---
S
----
S
-
L
T
V
L
I
A
A
S
A
M
-------
Q
G
--
M
G
-
T
G
V
----
G
G
V
M
A
R
T
L
P
---
R
D
L
Y
E
-
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
G
I
L
V
-
S
P
L
------
L
A
P
--
L
I
G
G
L
L
DTM--------------------------
W
N
-----------
W
R
A
C
---
Y
L
---
F
L
L
V
L
C
A
G
V
T
F
S
M
A
---
R
--
W
M
---
P
E
T
R
P
V
D
--
A
P
--------------------------------------------------------
R
T
R
L
L
T
-
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
-
L
L
M
L
I
G
G
L
A
G
I
A
A
F
E
A
C
S
G
V
L
M
G
-----------
A
V
-
L
-
G
---
L
S
S
M
T
V
------
S
-
I
L
F
I
----
L
P
---
I
P
---
A
-
A
F
F
G
A
--------------
W
F
A
G
R
P
N
K
--
R
F
S
T
L
M
W
Q
S
V
I
-
C
--
C
-
L
---
L
A
G
L
L
M
W
I
P
D
W
-----
F
--
G
V
M
---
N
-
V
-----
W
T
L
L
-
V
-
P
----
A
A
L
F
F
F
G
A
G
M
L
F
--
P
-------
L
-----------
A
T
S
G
--
A
M
-
E
P
F
P
-
F
L
A
G
T
A
G
A
---
L
V
-
G
---
G
L
Q
N
I
G
S
G
----------
V
-
L
-----
A
S
--
L
S
A
M
L
P
--
Q
T
G
Q
G
S
L
G
L
-----
L
M
T
L
M
G
L
L
I
V
L
C
W
-
L
-
P
----
L
-----------------------------------------------------------
33
HHSearch
50.27
15%
-104
- C5 -
2CFQ
-
LACY_ECOLI
A:
[37-393]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
-
N
H
I
S
---
K
S
D
T
G
I
I
F
A
A
I
S
L
F
S
L
L
-
F
Q
P
L
---
F
G
L
L
S
-
D
K
L
G
L
R
----
K
--
Y
L
L
--
W
I
I
T
G
M
L
--
V
M
F
A
---
P
F
F
I
----------------
F
I
F
G
---
P
----
L
L
Q
Y
N
I
L
V
G
S
I
V
-------
G
G
--
I
Y
-
L
G
F
CFNA
G
A
P
A
V
E
A
F
I
---
E
K
V
S
R
---
R
S
N
F
E
F
G
R
A
-
R
M
F
G
C
V
-
G
W
A
------
L
G
A
--
S
I
V
G
I
M
F
T
---------------------------
I
N
-----------
N
Q
F
V
---
F
W
---
L
G
S
G
C
A
L
I
L
-
A
V
L
L
---
F
--
F
A
---
K
T
D
A
P
S
S
--
A
-
T
-
V
A
N
A
V
----------------
G
----------------------------
A
-
N
H
S
A
F
S
L
K
-
L
A
L
E
L
F
R
Q
P
K
L
W
F
L
-
S
L
Y
V
I
G
V
S
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
FA-------
T
G
E
Q
-
G
T
--
R
V
---
F
------
G
-
Y
V
T
T
----
M
G
---
E
L
---
L
-
N
A
S
I
M
--------------
F
F
A
P
L
I
I
N
--
R
I
G
G
K
N
A
L
L
L
A
-
G
--
T
-
I
---
M
S
V
R
I
I
G
S
S
F
A
----------
T
---
S
-
A
-----
L
E
V
V
-
I
-
L
----
K
T
L
H
M
F
E
V
P
F
L
L
--
V
-------
G
-----------
C
F
K
Y
--
I
T
-
S
Q
F
E
V
R
F
S
A
T
I
Y
L
---
V
C
F
C
---
F
F
K
Q
L
A
M
I
----------
F
-
M
-----
S
V
--
L
A
G
N
M
Y
E
S
I
G
F
Q
G
A
Y
L
V
-----
L
G
L
V
A
L
G
F
T
L
I
S
V
-
F
-
T
----
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
------------------------------------------
28
Fugue
47.86
18%
-81
- C4 -
4U6D
20
?
A:
[28-409]
----------------------
E
G
F
P
F
I
L
P
K
E
K
P
N
R
P
-------
L
S
A
A
M
Q
R
N
Y
D
N
Y
M
A
P
R
P
E
N
N
E
L
Y
T
-
Q
F
K
Y
T
E
L
K
G
F
DYNG
H
D
G
-
T
I
S
R
R
D
---------
P
S
K
V
I
Y
E
N
----
G
K
------
Y
Y
V
W
Y
T
Y
R
N
T
P
T
P
P
Q
G
A
K
N
S
N
D
T
I
P
S
A
D
-
W
D
L
A
-----
E
I
W
Y
A
T
S
K
D
G
F
T
W
E
E
Q
G
V
A
V
---
P
R
P
P
K
-
P
N
V
G
W
R
----
S
--
V
T
T
--
T
D
---
I
L
--
K
W
K
G
------------------------------------------
K
F
Y
L
Y
-------
Y
Q
--
G
F
-
M
E
A
----
S
-------
G
---
T
R
G
D
D
-
C
P
V
A
V
S
Y
A
D
S
P
D
G
P
W
T
P
H
-
T
E
V
------
V
I
P
--
N
G
K
K
G
E
-----------------------------
W
D
-----------
Q
Y
S
I
---
H
D
-----------------
P
Y
P
I
--
V
Y
---
K
D
-----------------
K
I
Y
L
Y
-----
Y
K
S
D
F
D
-
G
---
D
P
N
L
V
R
M
Q
G
L
A
I
A
-------------------
D
-
N
P
L
G
---------------------------
P
F
K
K
S
P
L
-----------
N
--
P
-
V
-------------------------
I
N
---
S
G
---
H
-
E
T
T
L
F
--------------
P
F
K
----------------------------
E
G
M
A
A
L
V
I
R
D
G
TEHN
T
V
--
Q
Y
A
---
E
D
G
-----
V
N
F
N
-
I
-
A
----
S
I
V
E
F
M
P
N
A
A
G
P
--
Y
-------
V
-----------
A
D
A
F
--
T
N
-
T
K
Y
-------
G
R
G
---
I
S
-
W
---
G
I
S
H
F
-
T
N
----------
A
-
T
-----
T
W
--
D
Q
N
H
-------------------
A
V
L
A
R
F
D
C
D
L
S
L
-
D
-
V
----
D
D
P
H
M
K
R
L
G
T
Y
F
K
P
E
F
Y
Y
Q
M
G
L
S
K
K
Q
R
E
R
I
------------------------------