@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KMCP1_HUMAN: (2015-12-08 )
MSALNWKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVISSTIANPTDVLKIRMQAQSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKLDL
Atome Classification :
(20 SA)
-------------------------------------------------------......--------------...10........20..----------------..---------.-----------------.---.-------.30.......----.40--.------.--....---..50----------------------..-------......-60.----..-----------------------------------.....70......--..80......-----..90......---.-----.---100-----.---....-----..110-----------.---..-----------------....120...-....130..-------.....140-----...--------.----.....---150..------.----....160---.....-----------------------..-----------170--....----..----..180...-----------...-----.190---...---...----.-----..200.....--.----.210.....--------..220.......230.......240..-----------.....-250.------......260---.......------270..----...-------------------..280.......290---------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------MSALNW--------------KPFVYG
G
L
A
S
I
TAECGT----------------FP---------I-----------------D---
L
-------
T
K
T
R
L
Q
I
Q
GQ----TND--
A
------
K
--
F
K
E
I
---
R
Y
R
G
----------------------
M
L
-------
H
A
L
V
R
I
-
G
R
E
----
E
G
-----------------------------------
L
K
A
L
Y
SG
I
A
P
A
M
L
--
R
QASYG
T
I
K
I-----G
T
Y
Q
S
L
K
R
L
F
---
I
-----E---RPE-----D---ETL
P
-----
I
N
V
I
C
-----------
G
---
I
L
-----------------
S
G
V
I
S
S
TIAN-PT
D
V
L
K
I
R
M
-------
Q
AQSNT-------IQG--------G----
M
I
G
N
F
---
M
N
I
Y
Q
------Q----EGT
R
G
L
W---KGVSL-----------------------T
A
-----------
Q
R
---
A
A
I
V
----
V
G----VELP
V
Y
D
I
-----------
T
K
K
-----
H
L
-----
I
L
S
---
G
LM----G-----
D
T
V
Y
T
H
F
L
S
S
--
F
----
T
C
G
L
A
G
A
LA--------SN
P
V
D
V
V
R
T
R
M
M
N
Q
R
V
L
RDGRCSGY
T
G
-----------
T
L
D
C
L
-
L
Q
T
W
------KNE
G
F
F
A
L
Y
---KGFWPN
W
------
L
R
LGP----
W
N
I
-------------------
I
F
F
V
T
Y
E
Q
L
K
KLDL----------------------------------------------------------
30
Fugue
81.16
27%
-48
- C5 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
------------------------------------------------------D
Q
A
L
S
F
L
--------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
----------------
A
P
---------
I
-----------------
E
---
R
-------
V
K
L
L
L
Q
V
Q
H
A
----
S
K
Q
--
I
------
S
---
A
E
K
---
Q
Y
K
G
----------------------
I
I
-------
D
C
V
V
R
I
-
P
K
E
----
Q
G
-----------------------------------
F
L
S
F
W
R
G
N
L
A
N
V
I
--
R
Y
F
P
T
Q
A
L
N
F
-----
A
F
K
D
K
Y
K
Q
I
F
---
L
GGVDR
H
---
K
Q
F
-----
W
---
R
Y
F
A
-----
G
N
L
A
S
-----------
G
---
G
A
-----------------
A
G
A
T
S
L
C
F
V
Y
-
P
L
D
F
A
R
T
R
L
-------
A
A
D
V
G
K
-------
G
A
A
QREFT---
G
----
L
G
N
C
I
---
T
K
I
F
K
------
S
----
D
G
L
R
G
L
Y
---
Q
G
F
N
V
-----------------------
S
V
-----------
Q
G
---
I
I
I
Y
----
R
A
----
A
Y
F
G
V
Y
D
T
-----------
A
K
G
-----
M
L
-----
P
D
P
---
K
------
N
-----
V
H
I
I
V
S
W
M
I
A
--
Q
----
T
V
T
A
V
A
G
L
V
--------
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
-
S
G
R
K
G
A
D
I
M
Y
T
G
-----------
T
V
D
C
W
-
R
K
I
A
------
K
D
E
G
P
K
A
F
F
---
K
G
A
W
S
N
V
------
L
R
G
M
G
-----
G
A
-------------------
F
V
L
V
L
Y
D
E
I
---------------------------------------------------------------
1
PsiBlast_PDB
75.06
38%
-58
- C5 -
2LCK
-
UCP2_MOUSE
A:
[17-296]
-----------------------------------------------------------------------------
F
L
G
A
G
T
A
A
C
I
A
D
L
I
T
----------------
F
P
---------
L
-----------------
D
---
T
-------
A
K
V
R
L
Q
I
Q
G
E
----
S
Q
G
L
V
R
------
T
--
A
A
S
A
---
Q
Y
R
G
----------------------
V
L
-------
G
T
I
L
T
M
-
V
R
T
----
E
G
-----------------------------------
P
R
S
L
Y
N
G
L
V
A
G
L
Q
--
R
Q
M
S
F
A
S
V
R
I
-----
G
L
Y
D
S
V
K
Q
F
Y
---
T
-----
K
---
G
S
E
-----
H
---
A
G
I
G
-----
S
R
L
L
A
-----------
G
---
S
T
-----------------
T
G
A
L
A
V
A
V
A
Q
-
P
T
D
V
V
K
V
R
F
-------
Q
A
Q
A
R
A
-------
G
G
G
RRYQ----
S
----
T
V
E
A
Y
---
K
T
I
A
R
------
E
----
E
G
I
R
G
L
W
---
K
G
T
S
P
-----------------------
N
V
-----------
A
R
---
N
A
I
V
----
N
C
----
A
E
L
V
T
Y
D
L
-----------
I
K
D
-----
T
L
-----
L
K
A
---
N
L
M
----
T
-----
D
D
L
P
C
H
F
T
S
A
--
F
----
G
A
G
F
C
T
T
V
I
--------
A
S
P
V
D
V
V
K
T
R
Y
M
N
S
A
L
------
G
Q
Y
H
S
-----------
A
G
H
C
A
-
L
T
M
L
------
R
K
E
G
P
R
A
F
Y
---
K
G
F
M
P
S
F
------
L
R
L
G
S
----
W
N
V
-------------------
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
----------------------------------------------------------
21
HHSearch
74.26
27%
-44
- C5 -
1OKC
10
ADT1_BOVIN
A:
[6-293]
----------------------------------------------------------
S
F
L
--------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
----------------
A
P
---------
I
-----------------
E
---
R
-------
V
K
L
L
L
Q
V
Q
H
A
----
S
K
Q
--
I
------
S
---
A
E
K
---
Q
Y
K
G
----------------------
I
I
-------
D
C
V
V
R
I
-
P
K
E
----
Q
G
-----------------------------------
F
L
S
F
W
R
G
N
L
A
N
V
I
--
R
Y
F
P
T
Q
A
L
N
F
-----
A
F
K
D
K
Y
K
Q
I
F
---
L
-----
G
---
G
V
D
RHKQ
F
W
---
R
Y
F
A
-----
G
N
L
A
S
-----------
G
---
G
A
-----------------
A
G
A
T
S
L
C
F
V
Y
-
P
L
D
F
A
R
T
R
L
-------
A
A
D
V
G
K
GAAQR--
E
F
T
--------
G
----
L
G
N
C
I
---
T
K
I
F
K
------
S
----
D
G
L
R
G
L
Y
---
Q
G
F
N
V
-----------------------
S
V
-----------
Q
G
---
I
I
I
Y
----
R
A
----
A
Y
F
G
V
Y
D
T
-----------
A
K
G
-----
M
L
-----
P
D
P
---
K
------
N
-----
V
H
I
I
V
S
W
M
I
A
--
Q
----
T
V
T
A
V
A
G
L
V
--------
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
S
G
R
K
-
G
A
D
I
M
Y
T
G
-----------
T
V
D
C
W
-
R
K
I
A
------
K
D
E
G
P
K
A
F
F
---
K
G
A
W
S
N
V
------
L
R
G
M
G
-----
G
A
-------------------
F
V
L
V
L
Y
D
E
I
---------------------------------------------------------------
3
PsiBlast_PDB
73.73
27%
-43
- C5 -
2C3E
4
ADT1_BOVIN
A:
[9-293]
---------------------------------------------------------------------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
----------------
A
P
---------
I
-----------------
E
---
R
-------
V
K
L
L
L
Q
V
Q
H
A
----
S
K
Q
--
I
------
S
---
A
E
K
---
Q
Y
K
G
----------------------
I
I
-------
D
C
V
V
R
I
-
P
K
E
----
Q
G
-----------------------------------
F
L
S
F
W
R
G
N
L
A
N
V
I
--
R
Y
F
P
T
Q
A
L
N
F
-----
A
F
K
D
K
Y
K
Q
I
F
LGG
V
-----
D
---
R
H
K
-----
Q
F
W
-
R
Y
F
A
-----
G
N
L
A
S
-----------
G
---
G
A
-----------------
A
G
A
T
S
L
C
F
V
Y
-
P
L
D
F
A
R
T
R
L
-------
A
A
D
V
G
K
-------
G
A
A
QREFT---
G
----
L
G
N
C
I
---
T
K
I
F
K
------
S
----
D
G
L
R
G
L
Y
---
Q
G
F
N
V
-----------------------
S
V
-----------
Q
G
---
I
I
I
Y
----
R
A
----
A
Y
F
G
V
Y
D
T
-----------
A
K
-------------------
G
M
L
----
P
-----
D
P
K
N
V
H
I
I
V
S
--
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
--------
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
S
G
-
R
K
G
A
D
I
M
Y
T
G
-----------
T
V
D
C
W
-
R
K
I
A
------
K
D
E
G
P
K
A
F
F
---
K
G
A
W
S
N
V
------
L
R
-
G
M
----
G
G
A
-------------------
F
V
L
V
L
Y
D
E
I
---------------------------------------------------------------
2
PsiBlast_PDB
72.26
27%
-43
- C5 -
1OKC
10
ADT1_BOVIN
A:
[9-293]
---------------------------------------------------------------------------
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
----------------
A
P
---------
I
-----------------
E
---
R
-------
V
K
L
L
L
Q
V
Q
H
A
----
S
K
Q
--
I
------
S
---
A
E
K
---
Q
Y
K
G
----------------------
I
I
-------
D
C
V
V
R
I
-
P
K
E
----
Q
G
-----------------------------------
F
L
S
F
W
R
G
N
L
A
N
V
I
--
R
Y
F
P
T
Q
A
L
N
F
-----
A
F
K
D
K
Y
K
Q
I
F
L
GG
V
-----
D
---
R
H
K
-----
Q
F
W
-
R
Y
F
A
-----
G
N
L
A
S
-----------
G
---
G
A
-----------------
A
G
A
T
S
L
C
F
V
Y
-
P
L
D
F
A
R
T
R
L
-------
A
A
D
V
G
K
-------
G
A
A
QREFT---
G
----
L
G
N
C
I
---
T
K
I
F
K
------
S
----
D
G
L
R
G
L
Y
---
Q
G
F
N
V
-----------------------
S
V
-----------
Q
G
---
I
I
I
Y
----
R
A
----
A
Y
F
G
V
Y
D
T
-----------
A
K
-------------------
G
M
L
----
P
-----
D
P
K
N
V
H
I
I
V
S
--
W
M
I
A
Q
T
V
T
A
V
A
G
L
V
--------
S
Y
P
F
D
T
V
R
R
R
M
M
M
Q
S
G
-
R
K
G
A
D
I
M
Y
T
G
-----------
T
V
D
C
W
-
R
K
I
A
------
K
D
E
G
P
K
A
F
F
---
K
G
A
W
S
N
V
------
L
R
-
G
M
----
G
G
A
-------------------
F
V
L
V
L
Y
D
E
I
---------------------------------------------------------------
20
HHSearch
72.08
39%
-54
- C5 -
2LCK
-
UCP2_MOUSE
A:
[14-298]
------------------------------------------------------------
T
--------------
V
K
F
L
G
A
G
T
A
A
C
I
A
D
L
I
T
----------------
F
P
---------
L
-----------------
D
---
T
-------
A
K
V
R
L
Q
I
Q
G
E
----
S
Q
G
--
L
------
V
R
T
A
A
S
A
---
Q
Y
R
G
----------------------
V
L
-------
G
T
I
L
T
M
-
V
R
T
----
E
G
-----------------------------------
P
R
S
L
Y
N
G
L
V
A
G
L
Q
--
R
Q
M
S
F
A
S
V
R
I
-----
G
L
Y
D
S
V
K
Q
F
Y
---
T
-----
K
---
G
S
E
-----
H
---
A
G
I
G
-----
S
R
L
L
A
-----------
G
---
S
T
-----------------
T
G
A
L
A
V
A
V
A
Q
-
P
T
D
V
V
K
V
R
F
-------
Q
A
Q
A
R
A
GGGR---
R
Y
Q
--------
S
----
T
V
E
A
Y
---
K
T
I
A
R
------
E
----
E
G
I
R
G
L
W
---
K
G
T
S
P
-----------------------
N
V
-----------
A
R
---
N
A
I
V
----
N
C
----
A
E
L
V
T
Y
D
L
-----------
I
K
D
-----
T
L
-----
L
K
A
---
N
L
M
----
T
-----
D
D
L
P
C
H
F
T
S
A
--
F
----
G
A
G
F
C
T
T
V
I
--------
A
S
P
V
D
V
V
K
T
R
Y
M
N
S
A
L
G
------
Q
Y
H
S
-----------
A
G
H
C
A
-
L
T
M
L
------
R
K
E
G
P
R
A
F
Y
---
K
G
F
M
P
S
F
------
L
R
L
G
S
----
W
N
V
-------------------
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
----------------------------------------------------------
6
PsiBlast_PDB
71.65
24%
-45
- C5 -
4C9H
5
ADT2_YEAST
A:
[27-309]
-----------------------------------------------------------------------------
F
L
M
G
G
V
S
A
A
V
A
K
T
A
A
----------------
S
P
---------
I
-----------------
E
---
R
-------
V
K
L
L
I
Q
N
Q
D
E
----
M
L
K
--
Q
------
G
--
T
L
D
R
---
K
Y
A
G
----------------------
I
L
-------
D
C
F
K
R
T
-
A
T
Q
----
E
G
-----------------------------------
V
I
S
F
W
R
G
N
T
A
N
V
I
--
R
Y
F
P
T
Q
A
L
N
F
-----
A
F
K
D
K
I
K
A
M
F
---
G
-----
F
---
K
K
E
-----
E
G
Y
A
K
W
F
A
-----
G
N
L
A
S
-----------
G
---
G
A
-----------------
A
G
A
L
S
L
L
F
V
Y
-
S
L
D
Y
A
R
T
R
L
-------
A
A
D
S
--------------------------
A
R
Q
F
NG
L
I
D
V
Y
K
------
K
T
L
K
S
D
G
V
A
G
L
Y
---
R
G
F
L
P
-----------------------
S
V
-----------
V
G
---
I
V
V
Y
----
R
G
----
L
Y
F
G
M
Y
D
------------
S
L
K
----------------------------------
L
A
S
F
L
L
G
--
W
----
V
V
T
T
G
A
S
T
C
--------
S
Y
P
L
D
T
V
R
R
R
M
M
----
M
T
S
G
Q
A
V
K
Y
D
G
-----------
A
F
D
C
L
-
R
K
I
V
------
A
A
E
G
V
G
S
L
F
---
K
G
C
G
A
N
I
------
L
R
-
G
V
----
A
G
A
-------------------
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
----------------------------------------------------------
32
Fugue
70.17
16%
-73
- C4 -
4QLA
1
HYEP_BOMMO
A:
[19-442]
-------------------------------------------------------
L
D
L
E
E
W
WGPPELKQKQDT
S
I
K
P
F
E
I
T
F
S
E
T
M
V
K
E
L
K
E
R
I
K
K
RRPFAPPLEGVG
F
K
---------
Y
-----------------
G
---
F
-------
N
S
K
Q
L
D
S
W
L
K
----
Y
W
A
--
E
------
E
--
Y
P
F
A
---
E
R
Q
K
----------------------
F
L
N
Q
Y
P
---
H
F
K
T
N
I
--------
Q
G
-----------------------------------
L
N
I
H
F
M
R
I
T
P
K
V
P
--
K
G
V
E
I
V
P
L
L
L
L
H
G
W
P
G
S
V
R
E
F
Y
E
A
I
---
P
-----
H
L
T
A
V
S
K
-----
D
---
R
N
F
A
-----
L
E
I
I
A
P
S
L
PGYGF
S
D
A
A
---
V
R
-----------------
P
G
L
A
A
A
E
V
A
V
-
I
F
K
N
L
M
A
R
L
-------
G
Y
K
Q
Y
Y
-------
V
Q
G
--------
G
D
W
G
A
L
I
G
S
A
---
M
A
T
F
F
------
P
----
K
E
I
I
G
F
H
---
S
N
M
A
L
-----------------------
T
L
-----------
S
P
---
A
A
T
F
----
L
E
----
F
V
G
A
L
F
P
S
LIVEPE-----
L
A
N
-----
R
L
YP
L
S
E
K
Y
S
---
T
L
L
----
E
-----
E
L
G
Y
M
H
I
Q
A
T
--
K
----
P
D
T
V
G
I
G
L
T
--------
D
S
P
A
G
L
L
A
Y
I
L
E
K
F
S
T
W
T
N
P
D
L
R
S
K
E
D
GGLSYRWT
K
D
Q
L
I
D
N
L
-
M
L
Y
W
------
S
T
K
S
I
V
T
S
M
---
R
L
Y
A
E
S
F
S
S
R
H
F
D
L
K
L
D
E
----
I
Q
V
Q
V
P
T
W
V
L
Q
A
KHEL
A
Y
Q
P
P
C
I
L
K
M
K
Y
P
K
L
V
N
A
S
V
I
EDGGHFLAFEL
P
E
I
F
A
K
D
V
L
K
A
I
G
E
F
R
K
L
K
N--------------------------
4
PsiBlast_PDB
68.57
23%
-37
- C5 -
4C9J
4
ADT3_YEAST
A:
[31-298]
-----------------------------------------------------------------------------
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
----------------
S
P
---------
I
-----------------
E
---
R
-------
V
K
I
L
I
Q
N
Q
D
E
----
M
I
K
--
Q
------
G
--
T
L
D
K
---
K
Y
S
G
----------------------
I
V
-------
D
C
F
K
R
T
-
A
K
Q
----
E
G
-----------------------------------
L
I
S
F
W
R
G
N
T
A
N
V
I
--
R
Y
F
P
T
Q
A
L
N
F
-----
A
F
K
D
K
I
K
L
M
F
---
G
-----
F
---
K
K
E
-----
E
G
Y
G
K
W
F
A
-----
G
N
L
A
S
-----------
G
---
G
A
-----------------
A
G
A
L
S
L
L
F
V
Y
-
S
L
D
F
A
R
T
R
L
-------
A
A
D
A
K
S
------------------------
A
R
Q
F
NG
L
T
D
V
Y
K
------
K
T
L
K
S
D
G
I
A
G
L
Y
---
R
G
F
M
P
-----------------------
S
V
-----------
V
G
---
I
V
V
Y
----
R
G
----
L
Y
F
G
M
F
D
------------
S
L
K
-------------------------------------
F
L
L
G
--
W
----
V
V
T
T
G
A
S
T
C
--------
S
Y
P
L
D
T
V
R
R
R
M
M
----
M
T
S
G
Q
A
V
K
Y
N
G
-----------
A
I
D
C
L
-
K
K
I
V
------
A
S
E
G
V
G
S
L
F
---
K
G
C
G
A
N
I
------
L
R
S
V
A
----
G
A
G
-------------------
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
----------------------------------------------------------
5
PsiBlast_PDB
66.11
23%
-38
- C5 -
4C9Q
5
ADT3_YEAST
A:
[31-298]
-----------------------------------------------------------------------------
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
----------------
S
P
---------
I
-----------------
E
---
R
-------
V
K
I
L
I
Q
N
Q
D
E
----
M
I
K
--
Q
------
G
--
T
L
D
K
---
K
Y
S
G
----------------------
I
V
-------
D
C
F
K
R
T
-
A
K
Q
----
E
G
-----------------------------------
L
I
S
F
W
R
G
N
T
A
N
V
I
--
R
Y
F
P
T
Q
A
L
N
F
-----
A
F
K
D
K
I
K
L
M
F
---
G
-----
F
---
K
K
E
------G
Y
G
K
W
F
A
-----
G
N
L
A
S
-----------
G
---
G
A
-----------------
A
G
A
L
S
L
L
F
V
Y
-
S
L
D
F
A
R
T
R
L
-------
A
A
D
A
K
S
------------------------
A
R
Q
F
NG
L
T
D
V
Y
K
------
K
T
L
K
S
D
G
I
A
G
L
Y
---
R
G
F
M
P
-----------------------
S
V
-----------
V
G
---
I
V
V
Y
----
R
G
----
L
Y
F
G
M
F
D
------------
S
L
K
-----
P
L
--------------------------
F
L
A
S
F
L
L
G
--
W
----
V
V
T
T
G
A
S
T
C
--------
S
Y
P
L
D
T
V
R
R
R
M
M
----
M
T
S
G
Q
A
V
K
Y
N
G
-----------
A
I
D
C
L
-
K
K
I
V
------
A
S
E
G
V
G
S
L
F
---
K
G
C
G
A
N
I
------
L
R
S
V
A
----
G
A
G
-------------------
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
----------------------------------------------------------
34
Fugue
64.17
18%
-73
- C2 -
4J1Q
1
A:
[20-445]
H
M
E
R
L
M
L
E
P
V
WEKQNEELSYT
E
H
I
I
V
L
F
ETE
R
S
V
T
D
S
I
A
S
H
M
KD
A
R
V
I
T
L
NEAVG
H
I
A
E
R
Y
--------------
Q
C
Y
M
Q
N
I
F
E
L
L
Q
S
K
V
R
K
----------------
L
S
A
G
R
I
I
I
Q
A
I
V
-----------------
P
---
L
-------
E
K
E
K
Q
L
F
A
G
V
----
S
G
L
--
F
------
K
--
T
A
E
I
---
E
F
S
K
----------------------
L
T
-------
A
Q
V
I
E
I
-
E
K
P
----
E
E
-----------------------------------
M
I
D
L
H
L
K
L
K
D
D
S
R
--
R
P
F
D
K
-
Q
I
R
Y
-----
E
A
G
Y
R
F
V
K
G
W
---
R
-----
E
---
M
V
D
-----
T
---
L
H
M
P
WRD
E
G
V
Y
L
I
T
-----------
G
GAG
S
L
-----------------
G
L
L
F
A
K
E
I
A
N
-
R
T
G
R
S
T
I
V
L
T
G
RSVLS
E
D
K
E
N
E
-------
L
E
A
--------
L
----
R
S
I
G
A
---
E
V
V
Y
R
EADVSD
Q
----
H
A
V
R
H
L
L
---
E
E
I
K
E
R
Y
GTLNGIIHG
A
G
S
S
K
D
R
F
IIHK
T
N
-----------
E
E
---
F
Q
E
V
L
QPK
V
S
----
G
L
L
H
V
D
E
C
-----------
S
K
D
FPLD
F
F
I
-----
F
F
S
SVS
G
C
L
----
G
NAGQ
A
D
Y
A
A
A
N
S
F
M
D
--
A
----
F
A
E
Y
R
R
S
L
A
--------
A
S
K
K
R
F
G
S
T
I
S
F
N
W
P
L
W
E
E
G
G
M
Q
V
G
A
E
-----------
D
E
K
R
M
-
L
K
T
T
GMVPMP
T
D
S
G
L
K
A
F
Y
---
Q
G
I
V
S
D
-----------------
K
P
-------------------
Q
V
F
V
M
E
G
Q
L
Q
K
M
K
Q
K
LL-------------------------------------------------------
31
Fugue
63.31
19%
-58
- C4 -
3ACP
-
RPN14_YEAST
A:
[1-417]
---------------------------------------------------MT
K
T
I
T
V
A
H
I
--------------
Q
Y
D
F
K
A
V
L
E
E
N
D
E
N
D
D
E
----------------
F
Y
---------
I
-----------------
N
---
V
D
KNLN
E
I
K
E
H
K
I
V
V
L
G
N
----
S
R
G
--
V
DAGKG
N
T
--
F
E
K
V
GSH
L
Y
K
A
----------------------
R
L
DG
H
D
F
L
F
N
T
I
I
R
D
-
G
S
K
----
M
L
-----------------------------------
K
R
A
D
Y
T
A
V
D
T
A
K
L
Q
M
R
R
F
I
L
G
T
T
E
------
G
D
I
K
V
L
D
S
N
F
---
N
-----
L
---
Q
R
E
-----
I
---
D
Q
A
H
-----
V
S
E
I
T
-----------
K
---
L
K
F
F
PSG------------
E
A
L
I
S
S
S
Q
D
M
-
Q
L
K
I
W
S
V
K
D
-------
G
S
N
P
R
T
-------
L
I
G
HRATVT
D
I
A
----
I
I
D
R
G
---
R
N
V
L
S
------
A
S
L--
D
G
T
I
R
L
W
E
CG
T
G
T
T
I
-----------------------
H
T
F
N
RKENPHDGV
N
S
---
I
A
L
F
----
V
G
----
T
D
R
Q
L
H
E
I
ST
S
K
K
N
N
LEFG
T
Y
G
-----
K
Y
-----
V
I
A
---
G
H
V
----
S
-----
G
V
I
T
V
H
N
V
F
S
KE
Q
----
T
I
Q
L
P
S
K
F
T
--------
C
S
-
C
N
S
L
T
V
D
G
N
N
A
N
Y
I
Y
A
G
Y
E
N
G
M
L
A
-----------
Q
W
D
-
L
-
R
S
P
E
------
C
P
V
G
E
F
L
I
N
---
E
G
T
P
I
N
N
------
V
Y
F
A
A
----
G
A
L
-------------------
F
V
S
S
G
F
D
T
S
I
K
L
D
I
I
S
D
PESERPAIEFE
T
P
T
F
LVSNDDEVS
Q
F
C
Y
V
SDDES
N
G
E
V
L
E
V
G
K
NN
F
C
A
L
Y
N
LSNP
39
Fugue
62.18
17%
-54
- C1 -
4QFR
3
AAKG1_RAT
C:
[28-322]
------------------------------------Y
T
T
F
M
K
S
HRCYDLIPT
S
S
K
L
V
V
F
D
T
--------------
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
----------------
A
A
---------
P
-----------------
L
---
W
-------
D
S
K
K
Q
S
F
V
G
M
----
L
T
I
--
T
------
D
--
F
I
N
I
---
L
H
R
Y
----------------------
Y
K
-------
S
A
L
V
Q
I
-
Y
E
L
----
E
E
-----------------------------------
H
K
--
I
E
T
W
R
E
V
Y
L
--
Q
D
S
F
K
P
L
V
C
I
-----
S
P
N
A
S
L
F
D
A
V
---
S
-----
S
---
L
I
R
-----
N
---
K
I
H
R
-----
L
P
V
I
------------
D
---
P
E
-----------------
S
G
N
-
T
L
Y
I
L
T
-
H
K
R
I
L
K
F
-
L
-------
K
L
F
I
T
S
-------
L
E
E
--------
L
----
Q
I
G
T
Y
---
A
N
I
A
M
------
V
----
R
T
T
T
P
V
Y
---
V
A
L
G
I
-----------------------
F
V
-----------
Q
H
RVS
A
L
P
V
----
V
D
----
E
K
G
R
V
V
D
I
-----------
Y
S
K
-----
F
D
-----
V
I
N
---
L
A
A
----
E
-----
K
T
--------------------------------
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
V
L
K
C
Y
L
H
E
T
L
E
A
-----------
I
I
N
R
L
-
V
E
A
E
------
V
H
R
L
V
V
V
D
E
---
H
D
---------------------
V
V
-------------------
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
----------------------------------------------------------
22
HHSearch
53.32
19%
-50
* C5 *
1OKC
8
ADT1_BOVIN
A:
[6-201]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
-----
K
D
F
L
A
-----------
G
---
G
V
-----------------
A
A
A
I
S
K
T
A
V
A
-
P
I
E
R
V
K
L
L
L
-------
Q
V
Q
H
A
S
KQISAEK
Q
Y
K
--------
G
----
I
I
D
C
V
---
V
R
I
P
K
------
E
----
Q
G
F
L
S
F
W
---
R
G
N
L
A
-----------------------
N
V
-----------
I
R
---
Y
F
P
T
----
Q
A
----
L
N
F
A
F
K
D
K
-----------
Y
K
Q
-----
I
F
-----
L
G
G
---
V
D
R
HKQ
F
W
-----
R
Y
F
A
G
N
L
A
S
G
--
G
----
A
A
G
A
T
S
L
C
F
--------
V
Y
P
L
D
F
A
R
T
R
L
A
A
D
V
G
K
G
-
A
A
Q
R
E
F
T
G
-----------
L
G
N
C
I
-
T
K
I
F
------
K
S
D
G
L
R
G
L
Y
---
Q
G
F
N
V
S
V
------
Q
G
I
I
I
----
Y
R
A
-------------------
A
Y
F
G
V
Y
D
T
A
K
G
M
L
P
----------------------------------------------------------
37
Fugue
51.38
12%
-29
- C3 -
3IYM
-
?
A:
[39-434]
-------------------------------------------------------
A
S
A
S
K
A
--------------
A
A
F
A
Q
G
G
S
S
D
P
V
P
M
P
G
K
----------------
Y
P
---------
V
V
F
STGAGEPTRDQEFAL
P
---
V
-------
H
K
A
F
P
L
F
G
S
V
SDKY
R
R
N
--
P
------
R
--
Y
A
E
F
---
R
A
H
S
EFTDGVFGTHLAVSSLLRLAQQ
L
V
-------
H
A
H
V
N
M
-
G
L
P
----
L
G
DF
A
P
L
A
S
S
D
V
R
I
P
S
A
L
A
S
V
V
N
Q
F
GEFSSPSIGTR
F
L
L
R
D
F
E
H
A
V
S
R
V
V
--
F
L
A
D
Q
L
W
T
N
G
-----
N
S
H
H
I
F
A
R
S
W
---
L
-----
P
---
M
S
N
-----
N
---
D
G
N
F
-----
K
T
I
V
A
-----------
S
---
R
L
LEFISAG
D
L
S
I
L
P
TVLE
D
A
V
L
S
G
E
V
P
E
-
A
W
E
Q
V
K
D
L
L
-------
G
D
A
P
G
V
-------
G
Q
V
--------
D
----
R
R
D
R
F
---
D
F
L
F
K
------
S
----
Y
A
D
V
G
Q
F
---
T
T
A
F
T
-----------------------
T
Q
-----------
A
A
---
S
D
V
L
----
T
E
----
L
G
L
P
W
N
S
P
-----------
S
A
G
-----
H
L
-----
N
W
Q
----
Y
S
----
T
-----
K
Q
R
F
T
F
L
A
D
T
--
W
----
A
K
L
S
A
A
Y
S
Q
FFELSSGL
A
T
R
Q
S
A
T
G
S
H
A
Q
M
V
D
L
T
S
V
E
G
V
T
V
L
K
A
-----------
A
L
A
L
S
-
A
P
E
F
------
S
L
A
A
C
F
P
P
S
---
C
I
F
V
G
G
L
------
T
R
R
V
V
----
V
T
T
-------------------
S
L
S
V
S
Q
R
A
T
E
F
C
Q
M
D
W
R-------------------------------------------------------
35
Fugue
51.36
14%
-51
* C4 *
3GN6
4
?
A:
[22-321]
------------------------------------------------------------
F
--------------
N
P
W
T
D
A
A
L
D
T
I
V
N
Q
A
L
T
----------------
L
Y
---------
A
-----------------
E
M
R
V
V
-------
P
A
H
H
D
A
F
L
A
A
----
I
D
T
--
V
------
S
--
A
K
L
R
---
V
L
P
G
----------------------
F
L
-------
S
L
A
L
K
Q
M
S
G
D
STMV
K
N
-----------------------------------
Y
P
E
T
Y
K
G
V
----
L
--
A
T
A
Y
L
D
G
V
A
A
-----
G
T
Q
P
Y
F
Y
N
L
F
---
V
-----
R
---
F
A
D
-----
G
---
R
A
A
R
-----
A
A
G
F
E
-----------
A
---
L
F
-----------------
E
T
H
I
H
P
L
L
H
A
M
A
D
G
P
---
E
L
-------
L
A
Y
R
A
V
-------
L
Q
S
--------
V
----
V
A
G
D
R
---
H
A
I
Y
R
G
-----
A
----
E
E
I
R
S
F
L
---
R
R
P
V
E
-----------------------
L
P
-----------
E
R
---
E
T
V
T
----
V
E
N
H
V
M
V
P
E
D
K
H
A
A
-----------
W
E
P
-----
Q
V
-----
A
I
L
---
L
Q
V
----
A
-----
Q
D
T
F
E
P
Q
D
E
P
--
S
----
G
V
G
L
P
G
A
R
D
--------
N
R
Y
Y
R
----
K
A
L
S
T
E
I
L
R
N
A
H
A
D
G
--
G
-----------
L
R
A
Y
I
M
H
G
V
W
------
E
S
V
W
D
H
E
N
S
H
L
D
P
R
F
L
A
A
A
------
G
P
V
G
A
AAVV
G
P
V
-------------------
E
P
F
Y
L
T
R
R
L
V
V
A
D
-----------------------------------------------------------
23
HHSearch
47.27
24%
-26
- C5 -
2LCK
-
UCP2_MOUSE
A:
[115-301]
----------------------------------------------------------
G
I
G
--------------
S
R
L
L
A
G
S
T
T
G
A
L
A
V
A
V
A
----------------
Q
P
---------
T
-----------------
D
---
V
-------
V
K
V
R
F
Q
A
Q
A
R
----
A
G
G
--------------
G
R
---
R
Y
Q
S
----------------------
T
V
-------
E
A
Y
K
T
I
-
A
R
E
----
E
G
-----------------------------------
I
R
G
L
W
K
G
T
S
P
N
V
A
--
R
N
A
I
V
N
C
A
E
L
-----
V
T
Y
D
L
I
K
D
T
L
---
L
-----
K
---
A
N
L
M----
T
---
D
D
L
P
-----
C
H
F
T
S
-----------
A
---
F
G
-----------------
A
G
F
C
T
T
V
I
A
S
-
P
V
D
V
V
K
T
R
Y
-------
M
N
S
A
L
G
-------
Q
Y
H
--------
S
----
A
G
H
C
A
---
L
T
M
L
R
------
K
----
E
G
P
R
A
F
Y
---
K
G
F
M
P
-----------------------
S
F
-----------
L
R
---
L
G
S
W
----
N
V
----
V
M
F
V
T
Y
E
Q
-----------
L
K
R
-----
A
L
-----
M
A
A
---
Y
Q
S
----
R
-----
E
A
P
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
43.58
46%
-64
- C5 -
2YHM
-
NCAP_HRSVA
A:
[54-83]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
D
--
A
------
N
--
H
K
F
T
---
G
L
I
G
----------------------
M
L
-------
Y
A
M
S
R
L
-
G
R
E
----
D
T
-----------------------------------
I
K
I
L
R
D
A
G
Y
H
V
K
A
--
N
G
V
D
V
T
T
H
R
Q
-----
D
I
N
G
K
E
M
K
F
E
---
V
-----
L
---
T
L
A
-----
S
---
L
T
T
E
-----
I
Q
I
N
I
-----------
E
---
I
E
-----------------
S
R
K
S
Y
K
K
M
L
K
-
E
M
G
E
V
A
P
E
Y
-------
R
H
D
S
P
D
-------
C
G
M
--------
I
----
I
L
C
I
A
---
A
L
V
I
T
------
K
----
L
A
A
G
D
R
S
---
G
L
T
A
V
-----------------------
I
R
-----------
R
A
---
N
N
V
L
----
K
N
----
E
M
K
R
Y
K
G
L
-----------
L
P
K
-----
D
I
-----
A
N
S
---
F
Y
E
----
V
-----
F
E
K
H
P
H
F
I
D
V
--
F
----
V
H
F
G
I
A
Q
S
S
--------
T
R
G
G
S
R
V
E
G
I
F
A
G
L
F
M
N
A
Y
G
A
G
Q
V
M
L
R
-----------
W
G
V
L
A
-
K
S
V
K
------
N
I
M
L
G
H
A
S
V
---
Q
A
E
M
E
Q
V
------
V
E
V
Y
E
----
Y
A
Q
-------------------
K
L
G
G
E
A
G
F
Y
H
I
L
N
N
----------------------------------------------------------
9
PsiBlast_PDB
42.86
46%
-64
- C5 -
2WJ8
-
NCAP_HRSVA
A:
[54-83]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
D
--
A
------
N
--
H
K
F
T
---
G
L
I
G
----------------------
M
L
-------
Y
A
M
S
R
L
-
G
R
E
----
D
T
-----------------------------------
I
K
I
L
R
D
A
G
Y
H
V
K
A
--
N
G
V
D
V
T
T
H
R
Q
-----
D
I
N
G
K
E
M
K
F
E
---
V
-----
L
---
T
L
A
-----
S
---
L
T
T
E
-----
I
Q
I
N
I
-----------
E
---
I
E
-----------------
S
R
K
S
Y
K
K
M
L
K
-
E
M
G
E
V
A
P
E
Y
-------
R
H
D
S
P
D
-------
C
G
M
--------
I
----
I
L
C
I
A
---
A
L
V
I
T
------
K
----
L
A
A
G
D
R
S
---
G
L
T
A
V
-----------------------
I
R
-----------
R
A
---
N
N
V
L
----
K
N
----
E
M
K
R
Y
K
G
L
-----------
L
P
K
-----
D
I
-----
A
N
S
---
F
Y
E
----
V
-----
F
E
K
H
P
H
F
I
D
V
--
F
----
V
H
F
G
I
A
Q
S
S
--------
T
R
G
G
S
R
V
E
G
I
F
A
G
L
F
M
N
A
Y
G
A
G
Q
V
M
L
R
-----------
W
G
V
L
A
-
K
S
V
K
------
N
I
M
L
G
H
A
S
V
---
Q
A
E
M
E
Q
V
------
V
E
V
Y
E
----
Y
A
Q
-------------------
K
L
G
G
E
A
G
F
Y
H
I
L
N
N
----------------------------------------------------------
18
PsiBlast_PDB
42.56
46%
-42
- C5 -
4UCD
-
?
A:
[27-56]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
D
--
A
------
N
--
H
K
F
T
---
G
L
I
G
----------------------
M
L
-------
Y
A
M
S
R
L
-
G
R
E
----
D
T
-----------------------------------
I
K
I
L
R
D
A
G
Y
H
V
K
A
--
N
G
V
D
V
T
T
H
R
Q
-----
D
I
N
G
K
E
M
K
F
E
---
V
-----
L
---
T
L
A
-----
S
---
L
T
T
E
-----
I
Q
I
N
I
-----------
E
---
I
E
-----------------
S
R
K
S
Y
K
K
M
L
K
-
E
M
G
E
V
A
P
E
Y
-------
R
H
D
S
P
D
-------
C
G
M
--------
I
----
I
L
C
I
A
---
A
L
V
I
T
------
K
----
L
A
A
G
R
S
G
---
L
T
A
V
I
-----------------------
R
R
-----------
A
N
---
N
V
L
K
----
N
E
----
M
K
R
Y
K
G
L
L
-----------
P
K
D
-----
I
A
-----
N
S
F
---
Y
E
V
----
F
-----
E
K
H
P
H
F
I
D
V
F
--
V
----
H
F
G
I
A
Q
S
S
T
--------
G
G
S
R
V
E
G
I
F
A
G
L
F
M
N
A
Y
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------