@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S7A6O_HUMAN: (2015-12-11 )
MEAARTAVLRVKRKRSAEPAEALVLACKRLRSDAVESAAQKTSEGLERAAENNVFHLVATVCSQEEPVQPLLREVLRPSRDSQQRVRRNLRASAREVRQEGRYRVLSSRRSLGTTSSGQESEYTPGNPEAAGNSGFQLLDLVHEEGEPEAASAGSCKTSDPDVILCNSVELIRERLTVSEDGPGVRRQEEQKHDDYVYDIYYLETATPGWIENILSVQPYSQEWELVNDDQEPEDIYDDEDDENSENNWRNEYPEEESSDGDEDSRGSADYNSLSEEERGSSRQRMWSKYPLDVQKEFGYDSPHDLDSD
Atome Classification :
(20 SA)
-----------------------------------------------........-----.10........20........30..---....-----..40........50.------.......60........70........------80........90....-....100.......110.......120....-------...130----........140.----......150........160..----.....--170-----------.---...-------....180-------.--.....--------.190---.......200.--.-.....210...-----....220.......230..-----.....240.......250.......260-.-----.....-----.270---........280...---------....290.-......--300....--...---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------ME
A
A
R
T
A
V
-----
L
R
V
K
R
KRSAE
P
A
E
A
L
V
L
A
C
K
R
L
R
S
D
---
A
V
E
S
-----
A
A
Q
K
T
S
E
G
L
E
R
A
AEN------N
V
F
H
L
V
A
T
V
CSQEE
P
V
Q
P
L
L
R
E
V
LRPS------R
D
S
Q
Q
R
V
R
R
N
L
R
A
S
A
R
-
E
V
R
Q
EG
R
Y
R
V
L
S
SRRSLGTTSSGQESEYTPG-------NPEAA-----GNSGF
Q
L
L
D
L
V
H----EEGEPEA-ASAGSCKTSDP
D
V
I
----
L
CN
S
V
--
E
L
------------
I
---
R
E
R-------LTVSEDG-------P--GVR
R
Q
--------
E
E
QK---HDD
Y
V
Y
D
I
Y
Y
L
--E-TAT
P
G
W
I
E
N
I
L-----SVQPYSQEWELVNDDQEPE-----DIYDDEDDENSENNWRNEYPEEESSDGD-E-----DSRGS-----ADY----NSL
S
E
E
E
RG
S
S
R
Q
R
---------
M
W
S
KYPL
D
-
V
Q
K
EFG--YDSPHDL--DSD---------
18
Fugue
81.29
17%
1
* C9 *
4QCC
-
DGOA_ECOLI
A:
[5-274]
--------------------------------------------------
T
K
L
P
L
-----
I
A
I
L
R
G
I
T
P
D
E
A
L
A
H
V
G
A
V
I
D
A
G
F
D
---
A
V
E
I
P
LNSP
Q
W
E
Q
S
I
P
A
I
V
D
A
Y
G
D
------
K
A
L
I
G
A
G
T
V
-
L
K
P
E
Q
V
D
A
L
A
R
------------
M
G
C
Q
L
I
V
T
P
N
I
H
S
E
V
I
-
R
R
A
V
G
Y
G
M
T
V
C
P
G
C
A
T
A
T
E
A
F
T
A
L
E
-----------------
A
-----
G
A
Q
A
L
K
I
F
P
-
S
S
----
A
F
G
P
Q
Y
I
-
K
A
L
K
A
V
L
P
S
D
I
A
V
F
----
A
V
G
G
V
TP
E
N
------------
L
---
A
Q
W
-------
I
D
A
G
C
A
G
-------
A
--
G
L
G
S
D
-------------------
L
Y
R
A
G
Q
S
--
V
-
E
R
T
A
Q
Q
A
A
A
F
V
-----
K
A
Y
R
E
A
Q
K
Q
K
E
Q
R
Q
D
Q
K
S
A
-----
Y
A
L
G
A
S
L
G
R
Y
M
E
N
S
L
K
E
Q
E
K
L
G
I
K
L
D
K
D
-
Q
-----
L
I
A
G
V
-----
Q
D
A
F
A
DK
S
K
L
S
D
Q
E
I
E
Q
T
L
Q
A
---------
F
E
A
-----------------------------------
20
Fugue
68.81
16%
40
* C8 *
4WZI
-
PDE4B_HUMAN
A:
[85-576]
VT
P
F
A
Q
V
L
A
S
L
R
S
V
R
N
N
F
T
IQ
K
L
A
M
E
T
L
E
E
L
D
W
A
L
D
Q
L
E
T
I
QT
Y
R
S
V
S
E
M
A
S
N
K
F
-----
K
R
M
L
N
R
E
L
T
H
L
S
E
M
S
R
C
G
N
Q
V
S
E
Y
I
---
S
N
T
F
-----
L
D
K
E
N
E
D
H
L
A
K
E
L
E
D
LNKWGL
N
I
F
N
V
A
G
Y
--
S
H
N
R
P
L
T
A
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
-
H
Y
H
S
D
V
A
Y
H
--
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
LDAVFT
D
L
E
I
L
A
-----
A
I
F
A
A
A
I
H
D
V
D
H
PGVS
N
Q
F
L
I
N
T
-
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
N
H
H
L
A
V
G
F
--
K
L
------------
L
---
Q
E
E
HADIFMN
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
--
M
V
L
A
T
--------
D
M
S
K
---
H
M
S
L
L
A
D
L
K
T
M
--
V
-
E
T
K
K
V
T
S
S
G
V
L
-----
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
A
A
-----
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
-----
R
E
R
G
M
EISPM
A
D
K
----
H
T
A
C
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
----
L
W
E
T
W
A
D
L
-
V
Q
P
D
-
A
--
Q
D
I
L
D
T
L
--
E
D
N
R
N
W
Y
Q
A
M
IP
23
Fugue
66.00
16%
23
- C7 -
4O6Y
2
ACFR2_ARATH
A:
[10-219]
--------------------------------------------------
P
I
F
M
V
-----
V
R
V
L
G
F
I
I
A
A
L
V
L
T
W
T
V
H
-----------
Y
R
G
-----
G
L
A
L
S
S
D
N
K
D
H
I
F
N
V
------
H
P
V
M
M
V
I
G
L
I
L
F
N
G
E
A
M
L
A
Y
K
S
V
-
Q
G
T
------
K
N
L
K
K
L
V
H
L
T
L
Q
L
T
A
F
-
I
L
S
L
I
G
V
W
A
A
L
K
F
H
I
D
K
G
I
-----
E
N
F
Y
S
---------
L
H
S
W
L
-----
G
L
A
C
L
F
L
F
A
F
Q
W
----
A
A
G
F
V
T
Y
-
W
Y
P
G
G
------------------------------------------------------
S
-------
R
--
N
S
R
A
S
--------
L
M
P
W
---
H
V
F
L
G
I
S
I
Y
A
L
A
L
V
-
T
A
T
T
G
I
L
E
K
V
T
-----
F
L
Q
V
--------------------------------
N
Q
V
I
T
R
Y
S
---------------------------
T
----
E
A
M
L
V
N
T
M
G
V
L
I
L
I
---------
L
G
G
F
V
I
L
G
-
V
V
T
--------------------------
16
Fugue
64.77
19%
16
- C6 -
3WUW
4
KI3L1_HUMAN
G:
[16-301]
----------------------------------------------------
K
P
F
-----
L
S
A
W
P
S
A
V
V
P
R
G
G
H
V
T
L
R
C
H
Y
R
H
R
---------------------------
F
------
N
N
F
M
L
Y
K
-------------
E
D
R
I
H
I
P
------
I
F
H
G
R
I
F
Q
E
S
F
N
M
S
P
V
-
T
T
A
H
A
G
N
Y
T
C
R
G
S
H
P
H
S
P
T
G
W
S
A
------
P
S
-------
N
P
-------------
V
V
I
M
V
T
G
----
N
H
R
K
P
S
L
L
A
H
P
G
P
L
V
K
S
G
E
R
V
I
----
L
Q
C
W
S
--
D
I
------------
M
---
F
E
H
-------
F
F
L
H
K
E
G
-------
I
SK
D
P
S
R
L
--------
V
G
Q
I
---
H
D
G
V
S
K
A
N
F
S
I
--
G
-
P
M
M
L
A
L
A
G
T
Y
R
-----
C
Y
G
S
V
T
H
T
P
Y
Q
L
S
A
P
S
D
P
L
-----
D
I
V
V
T
G
P
Y
E
K
P
S
L
S
A
Q
---
P
G
P
K
V
Q
A
G
E
-
S
VTLSC
S
S
R
S
S
-----
Y
D
M
----
Y
H
L
S
R
E
G
G
A
H
E
R
R
L
PAVRKVNRT
F
Q
A
D
F
P
L
G
G
T
Y
R
C
F
G
SF
R
H
S
P
Y
E
W
SD
P
S
D
PLLV-----
21
Fugue
61.68
15%
6
- C8 -
1KC6
2
T2C2_HAEIF
A:
[1-257]
----------------------------------------------------
S
F
I
----------
K
P
I
Y
Q
D
I
N
S
I
L
I
G
Q
K
V
K
R
P
A
---
A
G
E
P
-----
F
E
K
L
V
Y
K
F
L
K
E
N
L
S
D
------
L
T
F
K
-------
Q
Y
E
Y
L
N
D
L
F
M
K
--
N
P
A
------
I
I
G
H
E
A
R
Y
K
L
F
N
---------
S
P
T
L
L
F
L
L
S
R
G
K
A
A
T
E
N
W
S
I
E
N
L
F
E
E
K
-------
Q
N
D
T
A
D
I
L
L
V
K
D
Q
F
Y
E
L
L
D
V
K
T
----
R
N
I
S
K
S
A
-
Q
A
--------
P
N
I
I
----
S
A
Y
K
L
--
A
Q
------------
T
---
C
A
K
-------
M
I
D
N
K
E
F
-------
D
--------------------------
L
F
D
I
N
Y
L
--
E
-
V
D
W
E
L
N
G
E
D
L
V
-----
C
V
S
T
S
F
A
E
--
L
F
K
S
--
E
P
S
-----
E
L
Y
I
N
W
---
A
A
A
M
Q
I
Q
F
H
V
R
D
L
D
Q
G
F
N
G
-
T
-----
R
E
E
W
A
-----
K
S
Y
----
L
K
H
F
V
T
Q
A
E
Q
R
A
I
S
---------
M
I
D
K
F
V
K
P
-
F
K
K
Y
I
L
-----------------------
19
Fugue
57.04
13%
18
- C9 -
2E2X
1
NF1_HUMAN
A:
[28-277]
---------------------------------------------------
K
T
L
S
-----
I
F
Y
Q
A
G
T
S
K
A
G
N
P
I
F
Y
Y
V
A
R
R
F
K
T
G
QI-
N
G
D
L
-----
L
I
Y
H
V
L
L
T
L
K
P
Y
Y
A
K
------
P
-
Y
E
I
V
V
D
L
T
H
T
G
P
S
N
R
F
K
T
D
F
L
S
K
W
F
------
V
V
F
P
G
F
A
Y
D
N
V
S
A
V
Y
I
Y
N
C
N
S
W
V
R
E
Y
T
K
Y
H
E
R
L
L
T
G
L
K
G
S
K
R
L
V
F
I
D
C
-------
P
G
K
L
A
-----
E
H
I
E
H
E
Q
Q
K
L
----------
P
A
A
-
T
L
A
L
E
E
D
L
K
V
F
H
N
A
----
L
K
L
A
H
--
K
D
------------
T
---
K
V
S
-------
I
K
V
G
S
T
A
-------
V
--
Q
V
T
S
A
--------
E
R
T
K
V
LG
Q
S
V
F
L
N
D
I
Y
Y
A
--
S
-
E
-----
I
E
E
I
C
-----
L
V
D
E
--
N
Q
F
T
L
T
I
A
N
Q
G
T
P
-----
L
T
F
M
H
Q
E
C
E
A
I
V
Q
S
I
I
H
I
R
T
R
W
E
L
S
Q
P
D
-------------------------------------------------------------------------------------
2
PsiBlast_PDB
52.92
33%
40
- C10 -
3F1Y
-
?
A:
[314-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
S
R
M
S
Y
A
V
V
R
A
V
A
R
-
R
L
R
Q
E
G
R
L
Q
Q
L
R
E
----------------
P
G
-------
L
P
E
---------
S
F
F
Q
L
S
D
Y
L
H
----
A
V
A
T
P
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
52.67
33%
42
- C10 -
3O3P
1
?
A:
[314-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
S
R
M
S
Y
A
V
V
R
A
V
A
R
-
R
L
R
Q
E
G
R
L
Q
Q
L
R
E
----------------
P
G
-------
L
P
E
---------
S
F
F
Q
L
S
D
Y
L
H
----
A
V
A
T
P
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.10
33%
36
- C10 -
3KIA
-
?
A:
[314-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
L
S
R
M
S
Y
A
V
V
R
A
V
A
R
-
R
L
R
Q
E
G
R
L
Q
Q
L
R
E
----------------
P
G
-------
L
P
E
---------
S
F
F
Q
L
S
D
Y
L
H
----
A
V
A
T
P
E
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
49.78
10%
45
- C9 -
4GOX
1
?
A:
[13-303]
------------------------------------------------------
K
-----
Q
W
Q
K
P
D
H
K
N
P
N
P
I
A
F
I
L
S
S
P
R
S
G
S
T
---
L
L
R
V
-----
M
L
A
G
H
P
G
L
Y
S
P
P
E
L
H
------
L
L
P
F
E
T
M
G
D
R
H
Q
E
L
G
L
S
H
L
G
E
G
L
Q
R
A
L
------
M
D
L
E
N
L
T
P
E
A
S
Q
A
K
V
N
-
Q
W
V
K
A
N
T
P
I
A
D
I
Y
A
Y
L
Q
R
Q
A
E
Q
R
L
L
I
D
K
S
P
S
-------
Y
G
S
D
R
-----
H
I
L
D
H
S
E
I
L
F
----------------------------------
D
Q
A
--
K
Y
------------
I
---
H
L
V
-------
R
H
P
Y
A
V
I
-------
E
--
S
F
T
R
L
--------
R
M
D
N
---
P
Y
A
L
A
E
S
I
W
R
T
--
S
N
R
N
I
L
D
L
G
R
T
V
G
-----
A
D
R
Y
L
Q
V
I
Y
E
D
L
V
R
D
P
R
K
V
L
T
N
I
C
D
F
L
G
V
D
F
D
E
A
L
L
N
P
Y
S
G
D
R
L
T
D
V
G
D
P
---
N
-----
F
L
Q
H
K
-----
T
I
D
----
P
A
L
A
D
K
W
R
S
I
T
L
P
A
---------
A
L
Q
L
D
T
I
Q
-
L
A
E
T
F
A
--
Y
D
L
P
-----------------
1
PsiBlast_PDB
45.62
30%
8
- C10 -
4FCA
1
?
A:
[161-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
T
-
V
-
A
E
H
L
K
Q
E
D
P
A
A
L
----
L
K
K
H
D
--
E
I
------------
I
N
I
E
H
K
M
-------
S
G
L
S
K
D
G
-------
A
--
G
V
A
N
Q
GK
H
S
I
H
F
V
E
D
W
Y
---
T
D
D
Y
M
Y
A
T
Y
Y
R
--
T
-
A
Y
S
K
G
N
L
E
S
V
L
-----
N
L
E
------
E
L
T
N
D
G
W
G
P
W
-----
H
E
V
G
H
Q
H
Q
Q
D
T
W
L
W
D
G
L
G
E
V
T
V
N
I
Y
S
L
A
-
V
-----
Q
T
T
F
G
-----
H
K
T
----
R
L
E
Q
E
G
R
Y
E
A
A
F
A
Y
---------
L
G
K
P
D
A
Q
E
-
K
M
N
E
F
E
--
K
L
V
M
F
W
Q
--
L
H
L
---------
22
Fugue
43.54
10%
11
- C9 -
1K6D
-
ATOD_ECOLI
A:
[1-219]
---------------------------------------MKTKLMT
L
Q
D
A
-
T
G
F
F
RDG
M
T
I
M
V
G
G
F
M
G
I
G
T
P
S
R
L
V
E
A
L
L
E
S
G
V
R
D
L
T
L
I
A
N
-----
D
T
A
F
V
D
T
G
I
G
P
L
I
V
N
------
G
R
V
R
K
V
I
A
S
H
I
G
------
T
N
P
E
T
G
R
R
M
------
I
S
G
E
M
D
V
V
L
V
P
Q
G
T
L
I
-
E
Q
I
R
C
G
G
A
G
L
G
G
F
L
T
P
T
G
V
G
T
V
E
G
--------------------------------
K
Q
T
L
----
T
L
D
---
G
-
K
T
W
L
L
E
R
P
L
R
A
D
L
A
----
L
I
R
A
H
--
R
C
DTLG
N
L
T
Y
Q
LSA
R
---
N
F
N
-------
P
L
I
A
L
A
A
-------
D
--
I
T
L
V
E
--------
P
D
E
L
---
V
E
T
G
E
L
--
Q
P
D
--
H
-
I
V
T
P
G
A
V
I
D
H
I
IVSQE
S
----------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
39.55
34%
232
- C10 -
3CAY
4
?
A:
[4-25]
----------------------------------------------------------------------------------
A
A
E
---
A
A
E
K
-----
A
A
K
Y
A
A
E
A
A
E
K
A
A
K
A
------
A
N
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
36.43
20%
45
- C10 -
2PA8
-
RPOL_SULSO
L:
[52-76]
----------------------------------------------------
K
I
I
-----
V
K
I
L
T
D
G
S
I
T
P
K
D
A
L
L
K
A
I
E
N
I
R
G
M
---
T
S
H
Y
-----
I
D
E
I
K
G
L
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
30.11
26%
276
* C10 *
3ECH
-
?
C:
[3-21]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
T
E
Q
L
R
R
A
A
R
R
N
---------
A
W
D
L
Y
G
E
H
-
F
Y
---------------------------
8
HHSearch
29.23
50%
466
- C4 -
1PSB
-
STK38_HUMAN
C:
[72-83]
--------------------------------------------------
K
E
T
E
F
-----
L
R
L
K
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
27.22
19%
197
- C10 -
2APO
-
NOP10_METJA
B:
[36-56]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
L
E
D
---------
R
W
G
K
Y
R
R
M
-
L
K
R
A
L
K
--
N
K
N
------------------
5
PsiBlast_PDB
24.90
46%
142
- C5 -
1JOF
1
CMLE_NEUCR
A:
[304-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
S
G
G
H
S
N
A
V
-----
S
P
C
P
W
S
D
E
W
M
A
I
T
D
D
Q
E
G
W
-----
L
E
I
Y
R
W
K
D
E
F
L
H
R
V
A
R
V
R
I
P
E
P
G
F
G
M
N
A
-
I
-----
W
Y
D
---------------------------------------------------------------------------
10
HHSearch
24.51
23%
331
- C10 -
1K1F
-
BCR_HUMAN
A:
[8-20]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
A
W
K
A
Q
F
P
D
S
E
P
P
R
M
E
-
L
-----
R
S
V
G
D
-----
I
E
Q
----
E
L
E
R
A
K
A
S
I
R
R
L
E
Q
---------
E
V
N
Q
E
R
F
R
-
M
I
Y
L
Q
T
--
L
L
A
K
E
K
---------------
11
HHSearch
23.56
33%
763
- C2 -
3QRX
-
B:
[14-21]
---------------------------------------------------
P
A
L
I
-----
S
W
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------