@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T0831: (2014-06-25 )
TMEELLTSLQKKCGTECEEAHRQLVCALNGLAGIHIIKGEYALAAELYREVLRSSEEHKGKLKTDSLQRLHATHNLMELLIARHPGIPPTLRDGRLEEEAKQLREHYMSKCNTEVAEAQQALYPVQQTIHELQRKIHSNSPWWLNVIHRAIEFTIDEELVQRVRNEITSNYKQQTGKLSMSEKFRDCRGLQFLLTTQMEELNKCQKLVREAVKNLEGPPSRNVIESATVCHLRPARLPLNCCVFCKADELFTEYESKLFSNTVKGQTAIFEEMIEDEEGLVDDRAPTTTRGLWAISETERSMKAILSFAKSHRFDVEFVDEGSTSMDLFEAWKKEYKLLHEYWMALRNRVSAVDELAMATERLRVRDPREPKPNPPVLHIIEPHEVEQNRIKLLNDKAVATSQLQKKLGQLLYLTNLEK
Atome Classification :
(20 SA)
-----------.........10........20.......--.30........--40........50........60........70.----------..-.....80.-.......---90...---------------.....100.......110.......120.......130.......140.......150......--------.160.......170.......180.......190.......200...-....210.......--220.......230------...----.....240......---.250.......260.--......270....-----------...280.......290......-.300...-....310.......320.......330.......340.......350.......360....--...370.......380.......390....---..-.400.......410.......-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------
T
M
E
E
L
L
T
S
L
Q
K
K
CG
T
E
C
E
E
A
H
R
Q
L
V
C
A
L--NG
L
A
G
I
H
I
IKG--
E
Y
A
L
A
A
E
L
Y
R
E
V
L
RSS
E
E
HKGKLK
T
D
S
L
Q
R
L
H
A
----------
T
H
-
N
L
M
E
L
L
I
A-RHPGIPP---TLRDG---------------
R
L
E
E
E
A
K
Q
L
R
E
H
Y
M
S
KCN
T
E
V
A
E
A
Q
Q
A
L
Y
P
V
Q
Q
T
I
H
E
L
Q
R
K
IHSNS
P
W
W
L
N
V
I
H
R
A
I
E
FTI
D
E
E
--------
L
V
Q
R
V
R
N
E
I
T
S
N
Y
K
Q
QTGKL
S
M
S
E
K
F
R
D
CRGL
Q
F
L
L
T
T
Q
M
E
E
L
N
K
C
Q
-
K
L
V
R
E
A
V
K
NLEGPP--SRN
V
I
ESA
T
V
C
H
-------LRP----ARLP
L
N
C
C
V
F
C
K
A
D
---
E
L
F
T
E
Y
E
S
K
L
F
SNTV--K
G
Q
T
A
I
F
E
E
M
IED-----------EEGLVDDRAPTTTR
G
L
W
A
I
S
E
T
-
E
R
S
M
K
A
I
-
L
S
F
A
K
SHRF
D
V
E
F
VDEGSTS
M
D
L
F
E
A
W
K
K
E
Y
K
L
L
H
E
Y
W
M
A
L
R
N
R
V
S
A
V
D
E
L
A
M
A
T
E
R
LRVR--DPREPKPNP
P
V
L
H
I
IEPHEV
E
Q
N
R
I
K
LLND---KA-
V
A
T
S
Q
L
Q
K
K
L
G
Q
L
L
YLTNLEK-----
7
Fugue
91.71
16%
-21
- C1 -
4K70
1
?
A:
[2-483]
---------PG
S
M
E
A
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R
A
L
E
E
A
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H
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V
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E
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F
M
A
A
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R
E
T
P
A
G
V
R
G
--
L
W
A
R
A
L
R
L
A
C
R
A
Y
V
E
T
G
T
C
E
A
A
V
L
A
E
N
L
A
G
L
A
L
W
RLRHDWDEG
T
A
-
P
L
L
E
L
L
G
V
V
N
G
D
D
T
T
A
---
A
L
T
E
A
GLRTSAEFG
P
D
A
M
F
R
L
V
S
E
W
C
A
A
F
D
E
A
L
A
G
A
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S
A
D
D
V
L
A
A
P
R
V
V
P
P
E
Q
T
A
R
A
L
V
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P
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F
A
T
L
-
Y
D
M
D
F
V
Q
D
G
L
R
Y
V
A
Q
H
T
NWA
L
P
L
A
L
A
V
R
Q
M
Q
N
E
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L
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P
L
T
R
A
L
F
A
L
T
I
A
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F
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D
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Q
N
P
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L
R
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Q
F
A
E
A
A
R
A
V
D
-
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A
A
L
V
P
V
G
E
V
N
A
T
P
RT
A
V
E
V
R
V
S
A
A
L
A
H
GDAYVRE
L
R
P
G
T
V
A
R
R
L
R
T
D
Q
G
V
L
A
L
L
D
PGA
Q
A
V
H
V
A
A
A
A
D
L
D
H
T
Q
--
V
D
A
T
G
V
W
E
A
V
Q
A
S
AS
P
L
Q
V
V
E
A
L
V
T
A
G
F
T
R
R
H
C
D
L
L
E
R
A
V
L
D
R
A
P
R
L
T
D
A
Q
R
A
V
-
G
C
T
A
V
V
G
G
V
V
H
R
L
L
D
D
Y
G
P
G
L
D
Y
V
R
A
Y
T
D
V
A
D
T
L
E
P
L
Y
G
D
V
T
A
A
L
G
-
L
P
E
K
G
V
E
H
V
V
R
H
C
M
--
A
P
R
-----
P
P
T
E
H
V
G
A
A
R
A
A
L
L
R
E
V
A
A
A
E
R
---
R
A
G
L
A
H
S
A
A
R
E
A
L
N
T
W
L
A
F
R
A
Q
S
R
WGL--
12
Fugue
64.42
12%
-30
- C1 -
1DT9
-
ERF1_HUMAN
A:
[5-422]
PSA
A
D
R
N
V
E
I
W
K
I
K
K
L
I
K
S
L
E
A
A
R
G
N
G
--------------
T
S
M
I
S
L
I
I
P
P
K
DQ
I
S
R
V
A
K
M
L
A
D
E
F
G
T
A
S
N
I
K
S
R
V
N
R
L
S
V
L
G
A
I
T
S
----------
V
Q
-
Q
R
L
K
-----
L
Y
N
K
V
P
P
N
G
L
V
V
Y
C
G
---------------
T
I
V
T
E
E
G
K
E
K
K
V
N
I
D
F
E
P
F
K
P
I
N
T
S
L
Y
L
C
D
N
K
F
H
T
E
A
L
T
A
L
L
S
D
D
S
K
F
G
F
I
V
I
D
G
------
S
G
A
--------
L
F
G
T
L
Q
G
N
T
R
E
V
L
H
K
F
T
V
D
L
P
K
K
H
G
R
G
G
Q
S
A
L
R
F
A
R
L
R
M
E
K
R
H
N
Y
V
R
-
K
V
A
E
T
A
V
Q
L
F
I
-
S
G
--
D
K
V
N
V
A
G
L
V
L
A
G
-------
S
A
D
----
F
K
T
E
L
S
-----
Q
S
D
---
M
F
D
Q
R
L
Q
S
K
V
L
K
L
V
D
I
S
Y
G
G
E
N
G
F
N
Q
A
I
E
L
-----------
S
T
E
V
L
S
N
------------
V
K
F
-
I
Q
E
K
K
L
I
-
G
R
Y
F
D
E
I
S
Q
D
T
G
K
Y
C
F
G
V
E
D
T
L
K
A
L
E
M
G
A
----
V
E
I
L
I
V
Y
E
N
L
D
I
M
R
Y
V
L
I
L
Y
L
T
P
E
Q
E
K
D
--
K
S
H
F
T
E
S
M
P
L
L
E
W
F
A
N
N
Y
K
K
F
G
A
T
L
E
I
V
T
D
---
K
S
-
Q
E
G
S
Q
F
V
K
G
F
G
G
I
G
G
I
L
R
Y
R
V
D
F
Q
G
M
13
Fugue
64.41
11%
-18
- C1 -
1DIK
-
?
?:
[510-874]
--------------------
I
E
T
Q
E
A
S
V
S
G
S
F
E
R
I
M
V
W
A
--
D
K
F
R
T
L
K
V
R
T
N
----
A
D
T
P
E
D
T
L
N
A
V
K
L
G
A
E
G
I
G
L
C
R
T
E
H
M
F
F
E
A
D
----------
R
I
-
M
K
I
R
K
M
I
L
-
S
D
S
-----------------------------
V
E
A
R
E
E
A
L
N
E
L
I
P
F
Q
K
G
D
F
K
A
M
Y
K
A
L
E
G
R
P
M
T
V
R
Y
L
D
P
P
L
H
E
----
F
V
P
H
T
E
E
E
Q
A
E
L
A
K
N
--------------
M
G
L
T
L
A
E
V
K
A
K
V
D
E
L
H
E
F
N
P
M
M
G
H
R
G
C
R
L
A
V
T
--
Y
P
E
I
A
K
M
Q
T
R
A
V
M
E
A
A
I
E
V
K
E
E
T
--
G
I
D
I
V
P
E
I
M
I
P
-----------------
L
V
G
E
K
K
E
L
K
F
V
K
---
D
V
V
V
E
V
A
E
Q
V
K
K
E
K
G
--
S
D
M
Q
Y
H
I
G
T
M
I
E
I
-----------
P
R
A
A
L
T
A
D
A
I
A
E
E
A
E
F
F
S
F
G
T
N
-
D
L
T
Q
M
T
F
G
F
S
R
D
D
A
G
K
F
L
D
S
Y
Y
K
A
K
I
Y
E
S
D
P
F
A
R
L
D
Q
T
---------------
G
V
G
Q
L
V
E
M
A
V
K
K
G
R
Q
T
--
R
P
------
G
L
K
C
G
I
C
G
E
H
G
G
D
P
S
S
V
E
F
C
H
K
V
GL
N
Y
-
V
S
C
S
P
F
R
V
P
I
A
R
L
A
A
A
Q
A
A
L
N
N
K---
5
Fugue
62.32
9%
-29
- C1 -
3E0S
-
?
A:
[9-317]
--------------------------------------
L
--
Q
L
D
A
H
A
S
I
H
E
N
--
V
R
R
L
L
Q
F
T
T
S
I
M
E
A
N
E
E
G
I
R
K
D
I
D
S
E
F
L
H
D
F
R
V
----------
A
I
-
R
R
S
R
S
I
L
R
-
L
L
N
G
V
F
D
---
P
E
K
T
A
---------------
W
M
L
A
G
L
R
E
L
G
K
R
T
N
D
L
R
D
S
D
V
Y
L
L
R
---------
R
E
E
Y
T
S
L
L
P
P
S
L
R
P
A
L
D
P
F
F
S
D
L
E
-
A
D
K
R
L
--------
H
H
R
Q
F
C
R
Y
L
T
G
--------------------------------
R
E
Y
S
-
G
F
M
T
S
L
K
E
F
I
A
E
G
E
--
L
P
D
-----------------------------------------------
P
E
T
A
P
L
A
A
--
E
P
T
G
D
V
A
A
K
T
I
R
K
-----------
A
L
K
K
V
L
V
H
G
R
S
------------
D
A
E
L
H
E
L
-
R
I
D
C
K
K
L
R
Y
L
L
E
F
F
A
S
L
F
P
--------
P
K
A
T
A
Q
V
L
R
Q
M
K
T
L
Q
D
N
L
G
T
F
V
D
L
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Q
M
E
F
L
Q
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R
L
E
T
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S
E
A
A
A
I
G
G
L
L
T
T
L
Y
R
K
R
E
K
V
R
E
H
F
H
E
I
F
---
S
G
-
F
D
S
N
E
T
G
E
L
F
D
E
L
L
T
G
L
---------
6
Fugue
51.01
11%
3
- C1 -
1QOY
-
HLYE_ECOLI
A:
[-4-298]
------------------
S
M
A
E
I
V
A
D
K
T
V
E
V
V
K
N
A
I
E
T
A
--
D
G
A
L
D
L
Y
N
K
Y
L
--
D
Q
V
I
P
W
Q
T
F
D
E
T
I
K
E
---------------------------------------------------------------------------
L
S
R
F
K
Q
E
Y
S
Q
A
A
S
V
L
V
G
D
I
K
T
L
L
M
D
S
Q
D
K
Y
F
E
A
T
Q
T
V
Y
E
----
W
C
G
V
A
T
Q
L
L
A
A
Y
I
L
------------------------------------------------
L
F
D
E
Y
N
-------
E
K
K
A
S
A
Q
K
D
I
L
--
I
K
V
L
D
D
G
I
T
K
L
N
-------
E
A
Q
----
K
S
L
L
V
S
S
Q
S
F
N
N
A
S
---
G
K
L
L
A
L
D
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L
T
N
D
F
S
--
E
K
S
S
Y
F
Q
S
Q
V
D
K
I
-----------
R
K
E
A
Y
A
G
A
A
A
G
V
V
V
G
P
F
G
L
I
I
S
-
Y
S
I
A
A
G
V
-
V
E
G
K
L
I
P
E
L
K
N
K
L
K
S
V
Q
N
F
F
T
T
L
S
N
T
V
K
Q
A
N
K
D
I
D
A
A
K
L
K
L
T
T
E
I
A
A
I
G
E
I
K
T
E
T
E
T
T
R
F
Y
--
V
-----------------
D
Y
D
D
L
M
L
S
L
L
K
E
---
A
A
-
K
K
M
I
N
T
C
N
E
Y
Q
K
R
H
G
K
K
T
L
F
------
23
HHSearch
41.07
26%
3
- C1 -
3NF1
-
KLC1_HUMAN
A:
[253-309]
---------------------------------
D
V
A
T
M
L
--
N
I
L
A
L
V
Y
R
D
Q
N
--
K
Y
K
D
A
A
N
L
L
N
D
A
L
A
I
R
E
K
T
L
G
---
K
D
H
P
A
V
A
A
T
----------
L
N
-
N
L
A
V
L
Y
G
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
38.75
23%
4
- C1 -
4JHR
-
GPSM2_MOUSE
A:
[150-202]
----------------------------------
E
R
R
A
Y
--
S
N
L
G
N
A
Y
I
F
L
G
--
E
F
E
T
A
S
E
Y
Y
K
K
T
L
L
L
A
R
Q
L
K
-----
D
R
A
V
E
A
Q
S
----------
C
Y
-
S
L
G
N
T
Y
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
38.33
24%
4
- C1 -
3RO3
1
A:
[49-99]
-----------------------------------
R
I
A
Y
--
S
N
L
G
N
A
Y
I
F
L
G
--
E
F
E
T
A
S
E
Y
Y
K
K
T
L
L
L
A
R
Q
L
K
-----
D
R
A
V
E
A
Q
S
----------
C
Y
-
S
L
G
N
T
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
38.10
23%
5
- C1 -
4I1A
-
RAPI_BACSU
A:
[181-236]
--------------------------------
V
Q
T
V
R
C
Q
--
F
I
V
A
G
N
L
I
D
S
L
--
E
Y
E
R
A
L
E
Q
F
L
K
S
L
E
I
S
K
E
S
N
-----
I
E
H
L
I
A
M
S
----------
H
M
-
N
I
G
I
C
Y
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
38.03
21%
5
- C1 -
3RO3
1
A:
[6-61]
--------------------------------
A
A
Q
G
R
A
F
--
G
N
L
G
N
T
H
Y
L
L
G
--
N
F
R
D
A
V
I
A
H
E
Q
R
L
L
I
A
K
E
F
G
-----
D
K
A
A
E
R
I
A
----------
Y
S
-
N
L
G
N
A
Y
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
37.70
22%
3
- C1 -
4JHR
-
GPSM2_MOUSE
A:
[110-163]
----------------------------------
Q
G
R
A
F
--
G
N
L
G
N
T
H
Y
L
L
G
--
N
F
R
D
A
V
I
A
H
E
Q
R
L
L
I
A
K
E
F
G
-----
D
K
A
A
E
R
R
A
----------
Y
S
-
N
L
G
N
A
Y
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
37.31
22%
12
- C1 -
3RO2
1
GPSM2_MOUSE
A:
[181-235]
---------------------------------
A
Q
G
R
A
F
--
G
N
L
G
N
T
H
Y
L
L
G
--
N
F
R
D
A
V
I
A
H
E
Q
R
L
L
I
A
K
E
F
G
-----
D
K
A
A
E
R
R
A
----------
Y
S
-
N
L
G
N
A
Y
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
36.91
20%
11
- C1 -
3NF1
-
KLC1_HUMAN
A:
[337-392]
---------------------------------
D
V
A
K
Q
L
--
N
N
L
A
L
L
C
Q
N
Q
G
--
K
Y
E
E
V
E
Y
Y
Y
Q
R
A
L
E
I
Y
Q
T
K
L
---
G
P
D
D
P
N
V
A
K
T
----------
K
N
-
N
L
A
S
C
Y
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
36.87
22%
8
- C1 -
3SF4
-
GPSM2_HUMAN
A:
[194-247]
----------------------------------
Q
G
R
A
F
--
G
N
L
G
N
T
H
Y
L
L
G
--
N
F
R
D
A
V
I
A
H
E
Q
R
L
L
I
A
K
E
F
G
-----
D
K
A
A
E
R
R
A
----------
Y
S
-
N
L
G
N
A
Y
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
35.08
12%
18
- C1 -
3QWW
-
SMYD2_MOUSE
A:
[338-394]
---------------------------------
Y
M
L
H
M
M
--
Y
Q
A
M
G
V
C
L
Y
M
Q
--
D
W
E
G
A
L
K
Y
G
Q
K
I
I
K
P
Y
S
K
H
Y
P
---
V
Y
S
L
N
V
A
S
M
----------
W
L
-
K
L
G
R
L
Y
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
34.85
19%
18
- C1 -
1ELR
-
A:
[38-89]
-----------------------------------
M
T
Y
I
--
T
N
Q
A
A
V
Y
F
E
K
G
--
D
Y
N
K
C
R
E
L
C
E
K
A
I
E
V
G
R
E
N
R
----
E
D
Y
R
Q
I
A
K
A
----------
Y
A
-
R
I
G
N
S
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
34.71
17%
12
- C1 -
3U3W
-
?
A:
[155-206]
-----------------------------------
L
Y
I
E
--
N
A
I
A
N
I
Y
A
E
N
G
--
Y
L
K
K
G
I
D
L
F
E
Q
I
L
K
Q
L
E
A
L
H
----
D
N
E
E
F
D
V
K
V
----------
R
Y
-
N
H
A
K
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
33.91
18%
-15
- C1 -
3ZPJ
-
?
A:
[112-167]
---------------------------------
E
K
G
M
V
L
--
S
T
L
A
Y
H
L
A
I
A
G
--
Y
P
D
N
A
L
E
I
F
N
I
A
F
D
T
I
I
G
A
E
T
-----
S
Y
T
H
K
V
D
----------
G
I
L
R
I
G
D
L
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
33.76
11%
5
- C1 -
3N71
-
SMYD1_MOUSE
A:
[350-405]
----------------------------------
V
L
R
L
L
--
S
I
A
S
E
V
L
S
Y
L
Q
--
A
Y
E
E
A
S
H
Y
A
R
R
M
V
D
G
Y
M
K
L
Y
H
---
H
N
N
A
Q
L
G
M
A
----------
V
M
-
R
A
G
L
T
N
W
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
32.95
21%
14
* C1 *
3RO2
3
GPSM2_MOUSE
A:
[82-134]
----------------------------------
E
A
K
A
S
--
G
N
L
G
N
T
L
K
V
L
G
--
N
F
D
E
A
I
V
C
C
Q
R
H
L
D
I
S
R
E
L
N
-----
D
K
V
G
E
A
R
A
----------
L
Y
-
N
L
G
N
V
Y
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
User Run . : Multi Template Modeling Result:
(5 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
T
M
E
E
L
L
T
S
L
Q
K
K
CG
T
E
C
E
E
A
H
R
Q
L
V
C
A
LNG
L
A
G
I
H
I
IKG
E
Y
A
L
A
A
E
L
Y
R
E
V
L
RSS
E
E
HKGKLK
T
D
S
L
Q
R
L
H
A
T
H
N
L
M
E
L
L
I
ARHPGIPPTLRDG
R
L
E
E
E
A
K
Q
L
R
E
H
Y
M
S
KCN
T
E
V
A
E
A
Q
Q
A
L
Y
P
V
Q
Q
T
I
H
E
L
Q
R
K
IHSNS
P
W
W
L
N
V
I
H
R
A
I
E
FTI
D
E
E
L
V
Q
R
V
R
N
E
I
T
S
N
Y
K
Q
QTGKL
S
M
S
E
K
F
R
D
CRGL
Q
F
L
L
T
T
Q
M
E
E
L
N
K
C
Q
K
L
V
R
E
A
V
K
NLEGPPSRN
V
I
ESA
T
V
C
H
LRPARLP
L
N
C
C
V
F
C
K
A
D
E
L
F
T
E
Y
E
S
K
L
F
SNTVK
G
Q
T
A
I
F
E
E
M
IEDEEGLVDDRAPTTTR
G
L
W
A
I
S
E
T
E
R
S
M
K
A
I
L
S
F
A
K
SHRF
D
V
E
F
VDEGSTS
M
D
L
F
E
A
W
K
K
E
Y
K
L
L
H
E
Y
W
M
A
L
R
N
R
V
S
A
V
D
E
L
A
M
A
T
E
R
LRVRDPREPKPNP
P
V
L
H
I
IEPHEV
E
Q
N
R
I
K
LLNDKA
V
A
T
S
Q
L
Q
K
K
L
G
Q
L
L
YLTNLEK
57
99.34
100%
-57
- C- -
M057
-
A:
[23-422]
----------------------
Q
L
V
C
A
L
N
G
L
A
G
I
H
I
I
K
G
E
Y
A
L
A
A
E
L
Y
R
E
V
L
R
S
S
E
E
H
K
G
K
L
K
T
D
S
L
Q
R
L
H
A
T
H
N
L
M
E
L
L
I
A
R
H
P
G
I
P
P
T
L
R
D
G
R
L
E
E
E
A
K
Q
L
R
E
H
Y
M
S
K
C
N
T
E
V
A
E
A
Q
---------
I
H
E
L
Q
R
K
I
H
S
N
S
P
W
W
L
N
V
I
H
R
A
I
E
F
T
I
D
E
E
L
V
Q
R
V
R
N
E
I
T
S
--------------------------------
N
K
C
Q
K
L
V
R
E
A
V
K
N
L
E
G
P
P
S
R
N
---------------------------------
S
K
L
F
S
N
T
V
K
G
Q
T
A
I
F
E
E
M
I
E
D
E
E
G
L
V
D
D
R
A
P
T
-----------
E
R
S
M
K
A
I
L
S
F
A
K
S
H
R
F
D
V
E
F
V
D
E
G
S
T
--------
K
K
E
Y
K
L
L
H
E
Y
W
M
A
L
R
N
R
V
S
A
V
D
E
L
A
M
A
T
E
R
L
R
V
R
D
P
R
E
P
K
P
N
P
P
V
L
H
I
I
E
P
H
E
V
E
Q
N
R
I
K
L
L
N
D
K
A
V
A
T
S
Q
L
Q
K
K
L
G
Q
L
L
Y
L
T
N
L
E
K
54
98.76
100%
-48
- C- -
M054
-
A:
[23-422]
----------------------
Q
L
V
C
A
L
N
G
L
A
G
I
H
I
I
K
G
E
Y
A
L
A
A
E
L
Y
R
E
V
L
R
S
S
E
E
H
K
G
K
L
K
T
D
S
L
Q
R
L
H
A
T
H
N
L
M
E
L
L
I
A
R
H
P
G
I
P
P
T
L
R
D
G
R
L
E
E
E
A
K
Q
L
R
E
H
Y
M
S
K
C
N
T
E
V
A
E
A
Q
---------
I
H
E
L
Q
R
K
I
H
S
N
S
P
W
W
L
N
V
I
H
R
A
I
E
F
T
I
D
E
E
L
V
Q
R
V
R
N
E
I
T
S
--------------------------------
N
K
C
Q
K
L
V
R
E
A
V
K
N
L
E
G
P
P
S
R
N
---------------------------------
S
K
L
F
S
N
T
V
K
G
Q
T
A
I
F
E
E
M
I
E
D
E
E
G
L
V
D
D
R
A
P
T
-----------
E
R
S
M
K
A
I
L
S
F
A
K
S
H
R
F
D
V
E
F
V
D
E
G
S
T
--------
K
K
E
Y
K
L
L
H
E
Y
W
M
A
L
R
N
R
V
S
A
V
D
E
L
A
M
A
T
E
R
L
R
V
R
D
P
R
E
P
K
P
N
P
P
V
L
H
I
I
E
P
H
E
V
E
Q
N
R
I
K
L
L
N
D
K
A
V
A
T
S
Q
L
Q
K
K
L
G
Q
L
L
Y
L
T
N
L
E
K
53
98.65
100%
-46
- C- -
M053
-
A:
[23-422]
----------------------
Q
L
V
C
A
L
N
G
L
A
G
I
H
I
I
K
G
E
Y
A
L
A
A
E
L
Y
R
E
V
L
R
S
S
E
E
H
K
G
K
L
K
T
D
S
L
Q
R
L
H
A
T
H
N
L
M
E
L
L
I
A
R
H
P
G
I
P
P
T
L
R
D
G
R
L
E
E
E
A
K
Q
L
R
E
H
Y
M
S
K
C
N
T
E
V
A
E
A
Q
---------
I
H
E
L
Q
R
K
I
H
S
N
S
P
W
W
L
N
V
I
H
R
A
I
E
F
T
I
D
E
E
L
V
Q
R
V
R
N
E
I
T
S
--------------------------------
N
K
C
Q
K
L
V
R
E
A
V
K
N
L
E
G
P
P
S
R
N
---------------------------------
S
K
L
F
S
N
T
V
K
G
Q
T
A
I
F
E
E
M
I
E
D
E
E
G
L
V
D
D
R
A
P
T
-----------
E
R
S
M
K
A
I
L
S
F
A
K
S
H
R
F
D
V
E
F
V
D
E
G
S
T
--------
K
K
E
Y
K
L
L
H
E
Y
W
M
A
L
R
N
R
V
S
A
V
D
E
L
A
M
A
T
E
R
L
R
V
R
D
P
R
E
P
K
P
N
P
P
V
L
H
I
I
E
P
H
E
V
E
Q
N
R
I
K
L
L
N
D
K
A
V
A
T
S
Q
L
Q
K
K
L
G
Q
L
L
Y
L
T
N
L
E
K
52
98.57
100%
-52
- C- -
M052
-
A:
[24-421]
-----------------------
L
V
C
A
L
N
G
L
A
G
I
H
I
I
K
G
E
Y
A
L
A
A
E
L
Y
R
E
V
L
R
S
S
E
E
H
K
G
K
L
K
T
D
S
L
Q
R
L
H
A
T
H
N
L
M
E
L
L
I
A
R
H
P
G
I
P
P
T
L
R
D
G
R
L
E
E
E
A
K
Q
L
R
E
H
Y
M
S
K
C
N
T
E
V
A
E
A
Q
---------
I
H
E
L
Q
R
K
I
H
S
N
S
P
W
W
L
N
V
I
H
R
A
I
E
F
T
I
D
E
E
L
V
Q
R
V
R
N
E
I
T
S
--------------------------------
N
K
C
Q
K
L
V
R
E
A
V
K
N
L
E
G
P
P
S
R
N
---------------------------------
S
K
L
F
S
N
T
V
K
G
Q
T
A
I
F
E
E
M
I
E
D
E
E
G
L
V
D
D
R
A
P
T
-----------
E
R
S
M
K
A
I
L
S
F
A
K
S
H
R
F
D
V
E
F
V
D
E
G
S
T
--------
K
K
E
Y
K
L
L
H
E
Y
W
M
A
L
R
N
R
V
S
A
V
D
E
L
A
M
A
T
E
R
L
R
V
R
D
P
R
E
P
K
P
N
P
P
V
L
H
I
I
E
P
H
E
V
E
Q
N
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51
63.39
100%
34
- C- -
M051
-
A:
[2-486]
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