@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MCATL_HUMAN: (2015-12-08 )
MALDFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLGSPLMGLTFINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFATVTVVLTYARGEEAGPEGEAVPAAPAGPALAQPSSL
Atome Classification :
(20 SA)
-------------------------......-...10-----........20.--.......---30.--------.-------------.-----..--------..------.---------40--..-----...-------....----50...--------------....--------------------.----------------60---------.......-..-70.-..---....---.80---.....---.-.---------..------------------------------------90.-------.....--------..--------100..--.-....110.----......120--.-..-..--.-----------.-------.--.-130-.........140.--------.--------..-------...150-...-.------.--.--.160......-----...170-..-..--.....180.....----....190..-.--.-----..------------------------.200--...-....-------.------.--------210....-...--------220.--.--..-...-------230---------------------........-.240....----------....250--------------...------------..----...260----.------....-------..------------.-270...------...---.280-----------------------------....-----..----------.-290........300.------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------M
A
L
D
F
L
-
A
G
C
A
G
-----
G
V
A
G
VLVGHPF--
D
T
V
K
V
R
L
---
Q
V
Q--------S-------------V-----EK--------PQ------Y---------R---
G
T
-----
L
H
C
-------
F
K
S
I
----
I
K
Q
E
S
--------------
V
L
G
L
--------------------
Y
----------------
K
----------GLGSP
L
M
-
G
L
-
T
F
I
-
N
A
---
L
V
FG---VQ----G
N
T
L
R
---A-L---------GH------------------------------------D
S
P
-------
L
N
Q
F
L
--------
A
G
--------AAAG
A
--
I
-
Q
C
V
I
CC
P
M
----
E
L
A
K
T
R
L
----
Q
-LQ-DA--G-----------P-------A--R-T---YKG
S
L
D
C
L
A
Q
I
YG--------H--------EG-------
L
R
G
V
N
R
-
G
M
V
-
S
------
T
--
L
--
L
R--ETPSF
G
-----
V
Y
F
L
---
T
Y
-
D
A
--
L
T
R
A
LG--CEPGD----R
L
L
V
P
K
L
L
L-A--G-----G
T
------------------------
S
G
----
I
V
S
-
W
L
S
T-------Y------
P
--------
V
D
V
V
K
S
R
-
L
Q
A--------DGLR--G--A
P
-
R
Y
R
-------
G
-----------------------
I
L
D
C
V
H
Q
S
-
Y
R
-AE
G
W
R
----------
V
F
T
R
G
L
---------------
A
S
T
------------
L
L
----
R
AFPV-----N------A
A
T
F
-------
A
T
------------
V
-
T
V
V
L
T
Y
------ARG---EEAG-----------------------------PEGE-----AV----------P-A-APAGPALAQPSSL------------------
22
HHSearch
78.13
26%
-53
- C9 -
1OKC
10
ADT1_BOVIN
A:
[8-293]
--------------------------
L
K
D
F
L
-
A
G
G
V
A
-----
A
A
I
S
K
T
A
V
A
P
I
--
E
R
V
K
L
L
L
---
Q
V
Q
--------
H
-------------
A
-----
S
K
QISAE---
K
Q
------
Y
---------
K
---
G
I
-----
I
D
C
-------
V
V
R
I
----
P
K
E
Q
G
--------------
F
L
S
F
--------------------
W
----------------
R
----------
G
N
L
A
N
V
I
-
R
Y
-
F
P
T
-
Q
A
---
L
N
F
A
---
F
K
----
D
K
Y
K
Q
---
I
-
F
---------
L
G
GVDRHKQ
F
W
---------------------------
R
Y
F
-------
A
G
N
L
A
--------
S
G
--------
G
A
A
G
A
--
T
-
S
L
C
F
V
Y
P
L
----
D
F
A
R
T
R
L
----
A
-
A
D
-
V
G
--
K
-----------
G
-------
A
AQ
R
-
E
---
F
T
G
L
G
N
C
I
T
K
I
F
K
--------
S
--------
D
G
-------
L
R
G
L
Y
Q
-
G
F
N
-
V
------
S
--
V
--
Q
G
--
I
I
I
Y
R
A
-----
A
Y
F
G
---
V
Y
-
D
T
--
A
K
G
M
L
P
--
D
P
K
------
N
V
H
I
I
V
S
W
M
-
I
--
A
-----
Q
T
------------------------
V
T
----
A
V
A
-
G
L
V
S
-------
Y
------
P
--------
F
D
T
V
R
R
R
-
M
M
M
--------
Q
S
G
R
--
K
GA
D
I
-
M
Y
T
-------
G
-----------------------
T
V
D
C
W
R
K
I
-
A
K
-
D
E
G
P
K
----------
A
F
F
K
G
A
---------------
W
S
N
------------
V
L
----
R
G
M
G
------
G
------
A
F
V
L
-------
V
L
------------
Y
-
D
E
I
--------------------------------------------------------------------------------------------------------
34
Fugue
77.80
21%
-78
- C6 -
4Z0V
6
PDE12_HUMAN
A:
[7-440]
-----------------PPAFT
E
L
Q
L
P
R
Y
I
M
-
A
G
F
P
V
-----
C
P
K
L
S
L
E
F
G
D
P
--
A
S
S
L
F
R
W
---
Y
K
E
--------
A
KPGAAGS
S
W
T
E
T
D
V
-----
E
E
--------
R
V
------
Y
T
P
S
NADIG
L
R
---
L
K
-----
L
H
C
T
P
G
DGQR
F
G
H
S
----
R
E
L
E
S
--------------
V
C
V
V
--------------------
E
----------------
A
----------
G
P
G
T
-----
C
-
T
F
D
-
H
R
---
H
L
Y
T
KKV
T
E
----
D
A
L
I
R
---
T
-
V
---------
S
Y
------------------------------------
N
I
L
-------
A
D
T
Y
A
--------
Q
T
--------
E
F
S
R
T
--
V
-
L
Y
P
Y
C
A
P
Y
ALE
L
D
Y
R
Q
N
L
I
----
Q
-
K
E
-
L
T
--
G
Y
NAD
V
I
C
L
Q
EV
D
-------
R
--
A
-
V
---
F
S
D
S
L
V
P
A
L
E
A
F
G
--------
L
--------
E
G
-------
V
F
R
I
K
Q
H
E
G
L
-
A
------
T
--
F
--
Y
R
--
K
-
S
K
F
S
-----
L
L
S
Q
---
H
D
-
I
S
--
F
Y
E
A
L
E
--
S
D
P
L
H
----
K
E
L
L
E
K
L
V
L
Y
P
--
S
-----
A
Q
------------------------
E
K
----
V
L
Q
-
R
S
S
V
-------
L
------
Q
--------
V
S
V
L
Q
S
T
-
K
D
S
--------
S
K
R
I
--
C
--
V
A
-
N
T
H
L
YWHPKG
G
-----------------------
Y
I
R
L
I
Q
M
A
-
V
A
-
L
A
H
I
R
----------
H
V
S
C
D
L
YP
G
I
P
V
I
F
C
GDFNST
P
S
T
------------
G
M
----
Y
H
F
V
I
-----
N
GSIPED
H
E
D
W
-------
A
S
NGEEE
R
------
C
-
N
M
S
L
T
H
FFKLKS
A
C
G
---
E
P
A
Y
TNYVGGFHGCLDYIFIDLNALEVEQVIPL
P
S
H
E
-----
E
V
----------
T
-
T
-
H
Q
A
L
P
S
V
S
H
P
S
D
H
I
A
L
V
C
D
L
K
W
K--------
31
Fugue
76.94
24%
-59
- C9 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
--------------------DQ
A
L
S
F
L
K
D
F
L
-
A
G
G
V
A
-----
A
A
I
S
K
T
A
V
A
P
I
--
E
R
V
K
L
L
L
---
Q
V
Q
--------
H
-------------
A
SKQIS
A
E
--------
K
Q
------
Y
---------
K
---
G
I
-----
I
D
C
-------
V
V
R
I
----
P
K
E
Q
G
--------------
F
L
S
F
--------------------
W
----------------
R
----------
G
N
L
A
N
V
I
-
R
Y
-
F
P
T
-
Q
A
---
L
N
F
A
---
F
K
----
D
K
Y
K
Q
---
I
-
F
L
GGVDRHKQ
F
W
------------------------------------
R
Y
F
-------
A
G
N
L
A
--------
S
G
--------
G
A
A
G
A
--
T
-
S
L
C
F
V
Y
P
L
----
D
F
A
R
T
R
L
----
A
-
A
D
-
V
G
KG
A
-----------
A
-------
Q
--
R
-
E
---
F
T
G
L
G
N
C
I
T
K
I
F
K
--------
S
--------
D
G
-------
L
R
G
L
Y
Q
-
G
F
N
-
V
------
S
--
V
--
Q
G
--
I
I
I
Y
R
A
-----
A
Y
F
G
---
V
Y
-
D
T
--
A
K
G
M
L
----
P
D
P
K
----
N
V
H
I
I
V
S
W
M
-
I
--
A
-----
Q
T
------------------------
V
T
----
A
V
A
-
G
L
V
S
-------
Y
------
P
--------
F
D
T
V
R
R
R
-
M
M
M
--------
Q
S
G
R
KG
A
--
D
I
-
M
Y
T
-------
G
-----------------------
T
V
D
C
W
R
K
I
-
A
K
-
D
E
G
P
K
----------
A
F
F
K
G
A
---------------
W
S
N
------------
V
L
----
R
G
M
G
G
-----
A
------
F
V
L
V
-------
L
Y
------------
D
-
E
I
---------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.31
25%
-64
- C9 -
4C9H
5
ADT2_YEAST
A:
[25-294]
---------------------------
I
D
F
L
-
M
G
G
V
S
-----
A
A
V
A
K
T
A
A
S
P
I
--
E
R
V
K
L
L
I
---
Q
N
Q
--------
D
-------------
E
-----
M
L
--------
K
Q
GTLDRK
Y
---------
A
---
G
I
-----
L
D
C
-------
F
K
R
T
----
A
T
Q
E
G
--------------
V
I
S
F
--------------------
W
----------------
R
----------
G
N
T
A
N
V
I
-
R
Y
-
F
P
T
-
Q
A
---
L
N
F
A
---
F
K
----
D
K
I
K
A
---
M
-
F
---------
G
F
------------------------------------
K
K
E
EG
Y
A
K
W
F
A
G
N
L
A
--------
S
G
--------
G
A
A
G
A
--
L
-
S
L
L
F
V
Y
S
L
----
D
Y
A
R
T
R
L
A
A
DS-----------------------------
A
--
R
-
Q
---
F
N
G
L
I
D
V
Y
K
K
T
L
K
--------
S
--------
D
G
-------
V
A
G
L
Y
R
-
G
F
L
-
P
------
S
--
V
--
V
G
--
I
V
V
Y
R
G
-----
L
Y
F
G
---
M
Y
-
D
S
--
L
--------
K
------------------------------------------------------L
A
S
F
L
L
G
-
W
V
V
T
T
G
A
S
T
C
S
Y
------
P
--------
L
D
T
V
R
R
R
-
M
M
M
--------
T
S
G
Q
-----
A
V
-
K
Y
D
-------
G
-----------------------
A
F
D
C
L
R
K
I
-
V
A
-
A
E
G
V
G
----------
S
L
F
K
G
C
---------------
G
A
N
------------
I
L
----
R
G
V
A
G
-----
A
------
G
V
I
S
-------
M
Y
------------
D
-
Q
L
Q
M
I
L
------
F
G
K
---
K
F
K
--------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.89
26%
-56
- C9 -
2C3E
4
ADT1_BOVIN
A:
[10-279]
----------------------------
D
F
L
-
A
G
G
V
A
-----
A
A
I
S
K
T
A
V
A
P
I
--
E
R
V
K
L
L
L
---
Q
V
Q
--------
H
-------------
A
-----
S
K
QISAE---
K
Q
------
Y
---------
K
---
G
I
-----
I
D
C
-------
V
V
R
I
----
P
K
E
Q
G
--------------
F
L
S
F
--------------------
W
----------------
R
----------
G
N
L
A
N
V
I
-
R
Y
-
F
P
T
-
Q
A
---
L
N
F
A
---
F
K
----
D
K
Y
K
Q
---
I
F
L
---------
G
G
------------------------------------
V
D
R
-------
H
K
Q
F
W
R
Y
F
A
G
N
L
A
S
G
--------
G
A
A
G
A
--
T
-
S
L
C
F
V
Y
P
L
----
D
F
A
R
T
R
L
A
A
--
D
-
V
G
-
K
G
--
A
-----------
A
-------
Q
--
R
-
E
---
F
T
G
L
G
N
C
I
T
K
I
F
K
--------
S
--------
D
G
-------
L
R
G
L
Y
Q
-
G
F
N
-
V
------
S
--
V
--
Q
G
--
I
I
I
Y
R
A
-----
A
Y
F
G
---
V
Y
-
D
T
---
A
K
G
M
L
--
P
D
P
K
N
----
V
H
I
I
V
S
W
M
I
-
A
--
Q
-----
T
V
------------------------
T
A
----
V
A
G
--
L
V
S
-------
Y
------
P
--------
F
D
T
V
R
R
R
M
M
M
Q
--------
S
G
R
K
--
G
--
A
D
I
M
Y
T
-------
G
-----------------------
T
V
D
C
W
R
K
I
-
A
K
-
D
E
G
P
K
----------
A
F
F
K
G
A
---------------
W
S
N
------------
V
L
----
R
G
M
G
G
-----
A
------
F
V
L
V
-------
L
Y
------------
D
-
E
I
---------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
72.48
26%
-56
- C9 -
1OKC
10
ADT1_BOVIN
A:
[10-279]
----------------------------
D
F
L
-
A
G
G
V
A
-----
A
A
I
S
K
T
A
V
A
P
I
--
E
R
V
K
L
L
L
---
Q
V
Q
--------
H
-------------
A
-----
S
K
QISAE---
K
Q
------
Y
---------
K
---
G
I
-----
I
D
C
-------
V
V
R
I
----
P
K
E
Q
G
--------------
F
L
S
F
--------------------
W
----------------
R
----------
G
N
L
A
N
V
I
-
R
Y
-
F
P
T
-
Q
A
---
L
N
F
A
---
F
K
----
D
K
Y
K
Q
---
I
F
L
---------
G
G
------------------------------------
V
D
R
-------
H
K
Q
F
W
R
Y
F
A
G
N
L
A
S
G
--------
G
A
A
G
A
--
T
-
S
L
C
F
V
Y
P
L
----
D
F
A
R
T
R
L
A
A
--
D
-
V
G
-
K
G
--
A
-----------
A
-------
Q
--
R
-
E
---
F
T
G
L
G
N
C
I
T
K
I
F
K
--------
S
--------
D
G
-------
L
R
G
L
Y
Q
-
G
F
N
-
V
------
S
--
V
--
Q
G
--
I
I
I
Y
R
A
-----
A
Y
F
G
---
V
Y
-
D
T
---
A
K
G
M
L
--
P
D
P
K
N
----
V
H
I
I
V
S
W
M
I
-
A
--
Q
-----
T
V
------------------------
T
A
----
V
A
G
--
L
V
S
-------
Y
------
P
--------
F
D
T
V
R
R
R
M
M
M
Q
--------
S
G
R
K
--
G
--
A
D
I
M
Y
T
-------
G
-----------------------
T
V
D
C
W
R
K
I
-
A
K
-
D
E
G
P
K
----------
A
F
F
K
G
A
---------------
W
S
N
------------
V
L
----
R
G
M
G
G
-----
A
------
F
V
L
V
-------
L
Y
------------
D
-
E
I
---------------------------------------------------------------------------------------------------------
32
Fugue
69.01
17%
-71
* C8 *
3ZPJ
-
?
A:
[1-356]
-------------------M
T
T
L
E
E
I
N
L
L
V
E
-
R
G
Y
Y
E
-----
E
A
L
A
K
V
Y
E
I
E
D
--
P
I
E
Q
V
Q
V
---
L
T
K
--------
I
-------------
V
-----
V
T
--------
I
Y
------
Q
---------
H
---
D
G
-----
P
M
E
-------
W
I
P
S
----
I
M
E
D
A
--------------
M
Y
I
A
--------------------
K
----------------
K
----------------
L
-
R
D
-
P
A
N
-
K
A
---
V
A
Y
S
---
I
I
----
A
S
T
L
A
---
I
-
M
---------
E
Y
------------------------------------
E
E
D
-------
A
M
D
F
F
--------
N
R
--------
A
I
D
E
A
N
E
I
-
E
S
P
I
E
K
G
M
----
V
L
S
T
L
A
Y
----
H
-
L
A
-
I
A
--
G
Y----------
P
-------
D
--
N
-
A
---
L
E
I
F
N
I
A
F
D
T
I
I
G
AETS
Y
T
H
K
V
--------
D
G
-------
I
L
R
I
G
D
-
L
L
E
-
K
------
A
--
G
D
T
L
P
--
S
N
E
A
M
D
-----
F
Y
K
M
---
A
F
-
D
I
--
F
D
K
-
L
H
--
V
N
Q
R
A
----
A
I
V
E
K
K
I
E
L
-
A
--
K
T
V
YDV
G
L
------------------------
P
Q
----
I
R
A
-
A
L
L
K
-------
G
------
K
--------
N
H
Y
A
L
A
I
-
I
K
K
--------
K
-
Y
S
--
G
--
V
M
-
R
L
I
-------
G
E
L
E
V
A
L
W
M
K
R
V
NNME--------
Y
L
D
V
V
D
K
A
-
F
E
-
C
C
E
S
P
----------
R
F
T
D
V
N
---------------
V
Q
H
------------
I
A
----
R
L
L
T
E
L
GN
L
R
R
------
A
L
K
F
-------
A
K
E
IQN
I
H
K
R
S
E
A
L
K
-
A
I
A
L
E
L
------
V
R
R
KKF
E
E
V
K
-----------------------------
K
I
I
E
-----
S
I
----------
P
D
P
-
K
I
R
E
E
A
L
N
E
I
G
T
I
E-----------------
33
Fugue
67.24
19%
-80
- C2 -
2IQH
-
?
A:
[21-489]
----------NAT
E
I
R
A
S
V
G
K
M
I
D
G
I
G
R
F
Y
I
-
Q
M
C
T
E
L
KLS-
D
Y
E
G
R
L
I
Q
N
S
L
--
T
I
E
R
M
V
L
---
S
A
F
--------
D
-------------
T
-----
G
G
--------
P
I
------
Y
---------
R
R
V
D
G
K
-----
W
R
R
-------
E
L
I
L
----
Y
D
K
E
E
--------------
I
R
R
I
--------------------
W
----------------
R
Q
A
N
N
GDDA
T
A
G
L
T
H
M
M
I
-
W
H
-
S
N
L
-
N
D
---
A
T
Y
Q
----
R
----
T
R
A
L
V
---
R
-
T
---------
G
M
------------------------------------
D
P
R
-------
M
C
S
L
M
--------
Q
G
STLPRRSG
A
A
G
A
A
--
V
-
K
G
V
G
T
M
V
M
----
E
L
I
R
M
I
K
----
R
-
G
I
-
N
R
--
R
-----------
T
-------
R
--
I
-
A
---
Y
E
R
M
C
N
I
L
K
G
K
F
Q
---------------------------
T
A
A
Q
R
-
T
M
V
-
D
------
Q
--
V
--
R
E
--
S
R
N
P
G
N
-----
A
E
F
E
---
D
L
-
I
F
--
L
A
R
S
A
L
--
I
L
R
G
S
V
A
H
-
K
S
C
L
P
A
C
V
Y
-
G
--
S
-----
A
V
A
S
GYDFEREGYSLVGI
D
P
F
R
L
L
Q
N
S
Q
----
V
Y
S
-
L
I
R
P
-------
N
------
E
--------
N
P
A
H
K
S
Q
-
L
V
W
M
A
C
H
SAAF
E
D
L
R
--
V
--
S
S
-
F
I
R
-------
G
TKVVPRGKLSTRGVQIASNENME
T
M
E
S
S
T
L
E
-
L
R
-
S
R
Y
W
A
----------
I
R
T
R
S
G
---------------
G
N
T
SSGQI
S
I
Q
P
TFS
V
Q
----
R
N
L
P
F
-----
D
------
R
P
T
I
M
AASD
M
R
T
E
------------
I
-
I
R
L
M
E
S
------
A
R
P
---
E
D
V
S
-----------------------------
F
Q
G
R
-----
G
V
F
E
LSDEKAT
S
P
-
I
-
V
P
S
F
D
M
S
N
E
G
S
Y
F
F-----------------
6
PsiBlast_PDB
67.22
23%
-69
- C9 -
4C9Q
5
ADT3_YEAST
A:
[27-299]
-------------------------
F
A
I
N
F
L
-
M
G
G
V
S
-----
A
A
I
A
K
T
A
A
S
P
I
--
E
R
V
K
I
L
I
---
Q
N
Q
--------
D
-------------
E
-----
M
I
--------
K
Q
GTLDKK
Y
---------
S
---
G
I
-----
V
D
C
-------
F
K
R
T
----
A
K
Q
E
G
--------------
L
I
S
F
--------------------
W
----------------
R
----------
G
N
T
A
N
V
I
-
R
Y
-
F
P
T
-
Q
A
---
L
N
F
A
---
F
K
----
D
K
I
K
L
---
M
-
F
---------
G
F
------------------------------------
K
K
E
G
Y
G
K
W
F
-
A
G
N
L
A
--------
S
G
--------
G
A
A
G
A
--
L
-
S
L
L
F
V
Y
S
L
----
D
F
A
R
T
R
L
A
A
DA
K
-
S
--------------------------
A
--
R
-
Q
---
F
N
G
L
T
D
V
Y
K
K
T
L
K
--------
S
--------
D
G
-------
I
A
G
L
Y
R
-
G
F
M
-
P
------
S
--
V
--
V
G
--
I
V
V
Y
R
G
-----
L
Y
F
G
---
M
F
-
D
S
--
L
K
P
L
---------------
F
L
A
S
F
L
L
-
G
--------------------------------------------
W
V
V
T
T
G
A
S
T
C
S
Y
------
P
--------
L
D
T
V
R
R
R
-
M
M
M
--------
T
S
G
Q
-----
A
V
-
K
Y
N
-------
G
-----------------------
A
I
D
C
L
K
K
I
-
V
A
-
S
E
G
V
G
----------
S
L
F
K
G
C
---------------
G
A
N
------------
I
L
----
R
S
V
A
G
-----
A
------
G
V
I
S
-------
M
Y
------------
D
-
Q
L
Q
M
I
L
------
F
G
K
--------------------------------------------------------------------------------------------
5
PsiBlast_PDB
66.45
23%
-62
- C9 -
4C9J
4
ADT3_YEAST
A:
[27-299]
-------------------------
F
A
I
N
F
L
-
M
G
G
V
S
-----
A
A
I
A
K
T
A
A
S
P
I
--
E
R
V
K
I
L
I
---
Q
N
Q
--------
D
-------------
E
-----
M
I
--------
K
Q
GTLDKK
Y
---------
S
---
G
I
-----
V
D
C
-------
F
K
R
T
----
A
K
Q
E
G
--------------
L
I
S
F
--------------------
W
----------------
R
----------
G
N
T
A
N
V
I
-
R
Y
-
F
P
T
-
Q
A
---
L
N
F
A
---
F
K
----
D
K
I
K
L
---
M
-
F
---------
G
F
------------------------------------
K
K
E
EG
Y
G
K
W
F
A
G
N
L
A
--------
S
G
--------
G
A
A
G
A
--
L
-
S
L
L
F
V
Y
S
L
----
D
F
A
R
T
R
L
A
A
DA
K
-
S
--------------------------
A
--
R
-
Q
---
F
N
G
L
T
D
V
Y
K
K
T
L
K
--------
S
--------
D
G
-------
I
A
G
L
Y
R
-
G
F
M
-
P
------
S
--
V
--
V
G
--
I
V
V
Y
R
G
-----
L
Y
F
G
---
M
F
-
D
S
--
L
K
---------------------
F
L
L
-
G
--------------------------------------------
W
V
V
T
T
G
A
S
T
C
S
Y
------
P
--------
L
D
T
V
R
R
R
-
M
M
M
--------
T
S
G
Q
-----
A
V
-
K
Y
N
-------
G
-----------------------
A
I
D
C
L
K
K
I
-
V
A
-
S
E
G
V
G
----------
S
L
F
K
G
C
---------------
G
A
N
------------
I
L
----
R
S
V
A
G
-----
A
------
G
V
I
S
-------
M
Y
------------
D
-
Q
L
Q
M
I
L
------
F
G
K
---
K
F
---------------------------------------------------------------------------------------
21
HHSearch
63.09
25%
-54
- C9 -
2LCK
-
UCP2_MOUSE
A:
[13-304]
-------------------------
M
T
V
K
F
L
-
G
A
G
T
A
-----
A
C
I
A
D
L
I
T
F
P
L
--
D
T
A
K
V
R
L
---
Q
I
Q
--------
G
-------------
E
-----
S
Q
G
L
V
R
T
A
AS
A
Q
------
Y
---------
R
---
G
V
-----
L
G
T
-------
I
L
T
M
----
V
R
T
E
G
--------------
P
R
S
L
--------------------
Y
----------------
N
----------
G
L
V
A
G
L
Q
-
R
Q
-
M
S
F
-
A
S
---
V
R
I
G
---
L
Y
----
D
S
V
K
Q
---
F
-
Y
---------
T
K
GSEH--------------------------------
A
G
I
-------
G
S
R
L
L
--------
A
G
--------
S
T
T
G
A
--
L
-
A
V
A
V
A
Q
P
T
----
D
V
V
K
V
R
F
----
Q
-
A
Q
-
A
R
--
A
-----------
G
G------
G
--
R
-
R
---
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
--------
E
--------
E
G
-------
I
R
G
L
W
K
-
G
T
S
-
P
------
N
--
V
--
A
R
--
N
A
I
V
N
C
-----
A
E
L
V
---
T
Y
-
D
L
--
I
K
D
T
L
L
--
K
A
N
L
M
----
T
D
D
L
P
C
H
F
T
-
S
--
A
-----
F
G
------------------------
A
G
----
F
C
T
-
T
V
I
A
-------
S
------
P
--------
V
D
V
V
K
T
R
-
Y
M
N
--------
S
A
L
G
--------
Q
Y
H
-------
S
-----------------------
A
G
H
C
A
L
T
M
-
L
R
-
K
E
G
P
R
----------
A
F
Y
K
G
F
---------------
M
P
S
------------
F
L
----
R
L
G
S
W
-----
N
------
V
V
M
F
-------
V
T
------------
Y
-
E
Q
L
K
R
A
------
L
M
A
---
A
Y
Q
S
-----------------------------
R
E
A
P
-----
F
----------------------------------------------
23
HHSearch
62.88
28%
-61
- C9 -
2LCK
-
UCP2_MOUSE
A:
[14-208]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
K
F
L
--------
G
A
--------
G
T
A
A
C
--
I
-
A
D
L
I
T
F
P
L
----
D
T
A
K
V
R
L
----
Q
-
I
Q
-
G
E
--
S
-----------
Q
G
L
V
R
T
A
A
S
--
A
-
Q
---
Y
R
G
V
L
G
T
I
L
T
M
V
R
--------
T
--------
E
G
-------
P
R
S
L
Y
N
-
G
L
V
-
A
------
G
--
L
--
Q
R
--
Q
M
S
F
A
S
-----
V
R
I
G
---
L
Y
-
D
S
--
V
K
Q
F
Y
T
--
K
G
S
-
E
----
H
A
G
I
G
S
R
L
L
-
A
--
G
-----
S
T
------------------------
T
G
----
A
L
A
-
V
A
V
A
-------
Q
------
P
--------
T
D
V
V
K
V
R
-
F
Q
A
--------
Q
A
R
A
--
G
G-
G
R
-
R
Y
Q
-------
S
-----------------------
T
V
E
A
Y
K
T
I
-
A
R
-
E
E
G
I
R
----------
G
L
W
K
G
T
---------------
S
P
N
------------
V
A
----
R
N
A
I
V
-----
N
------
C
A
E
L
-------
V
T
------------
Y
-
D
L
I
K
D
T
------
L
L
K
---
A
N
L
M
-----------------------------
T
D
D
L
-----
P
C
----------
H
-
F
-
T
S
A
F
G
A
G
F
C
T
T
V
I
------------------
1
PsiBlast_PDB
62.70
28%
-47
- C9 -
2LCK
-
UCP2_MOUSE
A:
[13-290]
-------------------------
M
T
V
K
F
L
G
A
G
T
A
A
-----
C
I
A
D
-
L
I
T
F
P
L
--
D
T
A
K
V
R
L
---
Q
I
Q
GESQG
L
V
R
T
-------------
A
-----
A
S
--------
A
Q
------
Y
---------
R
---
G
V
-----
L
G
T
-------
I
L
T
M
----
V
R
T
E
G
--------------
P
R
S
L
--------------------
Y
----------------
N
----------
G
L
V
A
G
L
Q
R
Q
M
-
S
F
A
-
S
V
R
I
G
L
Y
D
S
---
V
K
----
Q
F
Y
T
K
---
G
-
S
---------
E
H
------------------------------------
A
G
I
-------
G
S
R
L
L
--------
A
G
--------
S
T
T
G
A
--
L
-
A
V
A
V
A
Q
P
T
----
D
V
V
K
V
R
F
----
Q
-
A
Q
A
R
A
--
G
-----------
G
-------
G
--
R
-
R
---
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
--------
E
--------
E
G
-------
I
R
G
L
W
K
-
G
T
S
-
P
------
N
--
V
--
A
R
--
N
A
I
V
N
C
-----
A
E
L
V
---
T
Y
-
D
L
--
I
K
D
T
L
L
--
K
A
N
L
M
----
T
D
D
L
P
C
H
F
T
-
S
--
A
-----
F
G
------------------------
A
G
----
F
C
T
-
T
V
I
A
-------
S
------
P
--------
V
D
V
V
K
T
R
-
Y
M
N
--------
S
A
L
-------
G
-
Q
Y
H
-------
S
-----------------------
A
G
H
C
A
L
T
M
-
L
R
-
K
E
G
P
R
----------
A
F
Y
K
G
F
---------------
M
P
S
------------
F
L
----
R
L
G
S
W
-----
N
------
V
V
M
F
-------
V
T
------------
Y
-
E
Q
L
K
R
A
------
L
M
A
---
A
Y
Q
S
-----------------------------
R
E
A
P
-----
F
----------------------------------------------
24
HHSearch
61.19
26%
-61
* C9 *
1OKC
8
ADT1_BOVIN
A:
[6-205]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
-------
L
K
D
F
L
--------
A
G
--------
G
V
A
A
A
--
I
-
S
K
T
A
V
A
P
I
----
E
R
V
K
L
L
L
----
Q
-
V
Q
-
H
A
--
S
-----------
K
QISA---
E
--
K
-
Q
---
Y
K
G
I
I
D
C
V
V
R
I
P
K
--------
E
--------
Q
G
-------
F
L
S
F
W
R
-
G
N
L
-
A
------
N
--
V
--
I
R
--
Y
F
P
T
Q
A
-----
L
N
F
A
---
F
K
-
D
K
--
Y
K
Q
I
F
L
--
G
G
V
D
R
HKQ
F
W
R
Y
F
A
G
N
L
A
-
S
--
G
-----
G
A
------------------------
A
G
----
A
T
S
-
L
C
F
V
-------
Y
------
P
--------
L
D
F
A
R
T
R
-
L
A
A
--------
D
V
G
K
--
G
AA
Q
R
-
E
F
T
-------
G
-----------------------
L
G
N
C
I
T
K
I
-
F
K
-
S
D
G
L
R
----------
G
L
Y
Q
G
F
---------------
N
V
S
------------
V
Q
----
G
I
I
I
Y
-----
R
------
A
A
Y
F
-------
G
V
------------
Y
-
D
T
A
K
G
M
------
L
P
D
---
P
K
N
V
-----------------------------
H
I
I
V
-----
S
W
----------
M
-
I
-
A
Q
T
V
T
A
V
A
G
L
V
S
Y
------------------
40
Fugue
58.02
14%
-86
- C4 -
1K0E
2
PABB_ECOLI
A:
[3-453]
TLS
P
A
V
I
T
L
LWRQD
A
A
E
F
Y
F
S
RLSH
L
P
W
A
M
L
-
L
H
S
G
Y
ADHPY
S
R
F
D
I
V
V
A
E
P
I
--
C
T
L
T
T
F
G
---
K
E
T
--------
V
-------------
V
-----
S
E
--------
S
E
------
K
---------
R
---
T
T
T
TDD
P
L
Q
V
-------
L
Q
Q
V
----
L
D
R
A
D
IRPTHNEDLPFQG
G
A
L
G
L
--------------------
F
G
YD
L
G
R
R
F
E
SLPEIAE
Q
----------
D
I
V
L
P
D
M
-
A
V
-
G
I
Y
D
W
A
---
L
I
V
D
---
H
Q
----
R
H
T
V
S
---
L
-
L
---------
S
H
ND
V
N
A
R
R
A
W
L
E
S
QQFSPQE
D
F
T
L
TSDWQSNMT
R
E
Q
Y
G
E
K
-------
F
R
Q
V
Q
--------
E
Y
--------
L
H
S
G
D
--
C
Y
Q
V
N
L
A
Q
R
F
----
H
A
T
Y
S
G
D
----
E
-
W
Q
-
A
F
--
L
-----------
Q
-------
L
--
N
-
Q
---
A
N
R
A
P
F
S
A
F
L
R
L
E
--------
Q
G
A
I
L
S
LSP
E
R
-------
F
I
L
C
D
N
-
S
E
I
-
Q
T
R
P
I
K
G
T
--
L
--
P
R
AN
S
A
K
D
R
A
-----
E
N
L
M
---
I
V
-
D
L
--
M
R
N
D
I
G
R
V
A
V
A
G
S
----
V
K
V
P
E
L
F
V
V
-
E
P
F
P
-----
A
V
------------------------
H
H
----
L
V
S
-
T
I
T
A
-------
Q
L
P
EQLH
A
--------
S
D
L
L
R
A
A
-
F
P
G
--------
G
S
I
T
--
G
--
A
P
-
K
V
R
-------
A
M
E
---------------------
I
I
D
E
L
E
P
Q
-
R
R
N
A
W
C
G
S
----------
I
G
Y
L
S
F
---------------
C
G
N
------------
M
D
----
T
S
I
T
I
-----
R
------
T
L
T
A
-------
I
N
------------
G
-
Q
I
F
C
S
A
------
G
G
G
I
V
-
A
D
S
Q
-----------------------------
E
E
A
E
-----
Y
Q
----------
E
-
T
-
F
D
K
V
N
R
I
L
K
Q
L
E
K
------------------
39
Fugue
56.27
11%
-71
- C5 -
1NI3
-
OLA1_SCHPO
A:
[11-388]
----K
V
Q
W
G
R
PGNN
L
K
T
G
I
V
G
M
PNV
G
K
S
T
F
F
-
R
A
I
T
K
-----
S
V
L
G
N
P
A
N
Y
P
Y
--
A
T
I
D
P
E
E
---
A
K
V
--------
A
-------------
V
-----
P
D
--------
E
R
------
F
---------
D
---
W
L
-----
C
E
A
-------
Y
K
P
K
----
S
R
V
P
A
--------------
F
L
T
V
--------------------
F
D
I
A
G
L
T
KGASTG----
V
----------
G
L
G
N
A
F
L
-
S
H
V
R
A
V
-
D
A
---
I
Y
Q
V
---
V
R
AFDD
A
E
I
I
H
---
V
-
E
---------
G
D
------------------------------------
V
D
P
-------
I
R
D
L
S
--------
I
I
--------
V
D
E
L
L
--
I
-
K
D
A
E
F
V
E
K
----
H
L
E
G
L
R
K
----
I
-
T
S
-
R
G
--
A
NTLE
M
K
-----
A
-------
K
--
K
-
E
---
E
Q
A
I
I
E
K
V
Y
Q
Y
L
T
--------
E
--------
T
K
QPIRKGD
W
S
N
R
E
V
-
E
I
I
-
N
------
S
L
Y
L
--
L
T
--
A
K
P
--------
V
I
Y
L
---
V
N
M
S
E
--
R
D
F
L
R
Q
--
K
N
K
Y
L
----
P
K
I
K
K
W
I
D
E
-
N
--
S
-----
P
G
------------------------
D
T
----
L
I
P
M
S
V
A
F
-------
E
------
E
--------
R
L
T
N
F
T
E
-
E
E
A
--------
I
E
E
C
--
K
--
K
L
-
N
T
K
-------
S
M----------------------
L
P
K
I
I
V
T
G
-
Y
N
-
A
L
N
L
I
----------
N
Y
F
T
-
C
---------------
G
E
D
------------
E
V
----
R
S
W
T
I
-----
R
------
K
G
T
K
-------
A
P
------------
Q
-
A
A
G
V
I
H
------
T
D
F
---
E
K
A
F
-----------------------------
V
V
G
E
I
M
H
Y
Q
D
L
----------
F
-
D
-
Y
K
T
E
N
A
C
R
A
A
G
K
Y
L
T
K
G
KEYVMESG
D
I
A
H
W
K
36
Fugue
56.27
19%
-46
- C3 -
3J7W
-
CAPSA_BPT7
A:
[2-344]
-----------------------AS
M
T
G
G
Q
Q
-
M
G
T
N
Q
-----
G
K
G
V
V
A
A
G
D
K
L
--
A
L
F
L
K
V
F
G
G
E
V
L
T
--------
A
-------------
F
-----
A
R
--------
T
S
------
V
---------
T
---
T
S
-----
R
H
M
-------
V
R
S
I
S
SGK
S
A
Q
F
P
--------------
V
L
G
R
T
Q
A
A
Y
L
A
PGENLDD
K
R
K
D
I
K
H
----------------
T
----------
E
K
V
I
T
I
D
-
G
L
-
L
T
A
-
D
V
---
L
I
Y
D
---
I
E
----
D
A
M
N
H
YD
V
R
-
S
---------
E
Y
------------------------------------
T
S
Q
-------
L
G
E
S
L
--------
A
M
--------
A
A
D
G
A
--
V
-
L
A
E
I
A
G
L
C
----
N
V
E
S
K
Y
N
----
E
N
I
E
-
G
L
--
G
-----------
T
-------
A
--
T
-
V
---
I
E
T
T
Q
N
K
A
A
L
T
D
Q
--------
V
--------
A
L
-------
G
K
E
I
I
A
-
A
L
T
-
K
------
A
--
R
--
A
A
--
L
T
K
N
Y
V
PA
A
D
R
V
F
Y
C
D
P
D
S
Y
-
S
A
--
I
L
A
A
L
M
--
P
N
A
A
N
----
Y
----
A
A
L
I
-
D
--
P
-----
E
K
------------------------
G
S
----
I
R
N
-
V
M
G
F
-------
E
------
V
--------
V
E
V
--
P
H
-
L
T
A
--------
G
G
A
G
--
T
--
A
R
-
E
G
T
-------
T
-----------------------
G
Q
K
H
V
F
P
A
-
N
K
-
G
E
G
N
V
KVAKDNVI
G
L
F
M
H
R
S
A
---------------
V
G
T
------------
V
K
L
R
D
L
A
L
E
R
A
-----
R
------
R
A
N
F
-------
Q
A
------------
D
-
Q
I
I
A
K
Y
------
A
M
G
---
H
G
-
G
-----------------------------
L
R
P
E
-----
A
-----------------
A
G
A
V
V
F
K
V
---------------------
37
Fugue
45.02
13%
-41
- C8 -
5AFR
-
?
A:
[8-410]
-------------------------
L
A
N
E
L
I
-
E
F
V
A
A
-----
T
V
T
G
I
K
N
S
P
K
E
NE
Q
A
F
I
D
Y
L
---
H
C
Q
--------
Y
-------------
L
-----
E
R
--------
F
Q
------
F
---------
F
---
L
G
-----
L
F
V
-------
F
L
F
I
----
V
T
I
D
I
--------------
A
I
Y
D
--------------------
A
----------------
N
----------
L
A
N
S
T
L
L
-
I
I
-
K
Q
I
-
S
A
---
I
Y
N
A
---
G
N
----
L
A
S
I
I
---
T
-
H
---------
G
V
------------------------------------
S
S
V
-------
F
G
Q
L
I
--------
K
S
--------
D
I
D
K
T
--
R
-
R
K
L
D
D
I
S
K
----
Q
F
Q
Q
L
H
T
----
S
-
I
E
-
T
P
--
D
-----------
L
-------
L
--
A
M
V
P
S
I
I
K
L
A
V
S
K
G
A
T
S
H
D
--------
Y
--------
A
N
-------
Y
L
P
S
N
D
-
L
E
S
M
R
------
F
--
L
--
N
I
--
L
Q
S
I
A
N
-----
K
W
F
L
---
V
L
-
K
Q
T
L
F
L
D
E
V
E
--
F
W
S
N
F
----
Y
E
V
L
K
S
L
I
E
-
Q
--
T
-----
Q
S
------------------------
Q
E
----
F
Q
V
-
C
L
S
V
-------
L
------
T
N
AKRFHNL
T
N
L
L
N
E
G
-
S
L
S
--------
D
K
F
K
--
L
--
A
D
-
K
Y
N
-------
Q
-----------------------
F
L
S
S
I
P
I
D
E
D
L
-
Q
E
L
F
P
----------
V
L
A
S
S
L
---------------
K
K
F
------------
R
Y
----
S
G
Y
P
V
-----
Q
------
R
F
V
V
L
M
D
K
I
S
-
Q
E
------------
V
M
D
A
I
L
S
N
------
L
S
Y
---
G
S
F
L
-----------------------------
G
L
Y
E
-----
K
S
----------
A
-
G
M
I
E
E
W
D
D
I
V
Q
D
V
N
L
L
I
R---------------
11
PsiBlast_PDB
32.88
36%
-11
* C7 *
1W2C
1
IP3KA_HUMAN
A:
[4-49]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
A
-----
G
T
------------------------
S
G
----
L
I
L
-
K
R
C
S
-------
E
------
P
--------
E
R
Y
C
L
A
R
-
L
M
A
--------
D
A
L
R
--
G
C-
V
P
-
A
F
H
-------
G
-----------------------
V
V
E
R
D
G
E
S
-
Y
L
-
Q
L
Q
D
L
----------
L
D
G
F
D
G
---------------
P
C
V
------------
L
D
----
C
K
M
G
V
-----
R
------
T
Y
L
E
-------
E
E
------------
L
-
T
K
A
R
E
R
------
P
K
L
---
R
K
D
M
-----------------------------
Y
K
K
M
-----
L
A
----------
V
-
D
-
P
E
A
P
T
E
E
E
H
A
Q
R
A
------------------
12
PsiBlast_PDB
31.84
36%
-7
- C7 -
1W2D
1
IP3KA_HUMAN
A:
[4-49]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
A
-----
G
T
------------------------
S
G
----
L
I
L
-
K
R
C
S
-------
E
------
P
--------
E
R
Y
C
L
A
R
-
L
M
A
--------
D
A
L
R
--
G
C-
V
P
-
A
F
H
-------
G
-----------------------
V
V
E
R
D
G
E
S
-
Y
L
-
Q
L
Q
D
L
----------
L
D
G
F
D
G
---------------
P
C
V
------------
L
D
----
C
K
M
G
V
-----
R
------
T
Y
L
E
-------
E
E
------------
L
-
T
K
A
R
E
R
------
P
K
L
---
R
K
D
M
-----------------------------
Y
K
K
M
-----
L
A
----------
V
-
D
-
P
E
A
P
T
E
E
E
H
A
Q
R
A
------------------