@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MCAT_HUMAN: (2015-12-08 )
MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWATPNL
Atome Classification :
(20 SA)
-----------------------------------------------------------....--.....10........20.......------.30------.........40..-.----..-.----.--.--50---..-..-------....60--------...-------..-...70--...----.....-80..-------------.....---.90--------.---..-.-.....100------..-------..-----....110.--..--------.---------------...120.......130--......----------.------140....------.-.--..--------150....--...160.......170------------.........---180--..------....--.--190...-----....200...--.....-210.-------...--...220----...---.....230....-..--.240.----..-.----.----..250.--......260----.......--------..270......--------------------------.-280----...----...-...290..---.....300-----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------MADQ--PKP
I
S
P
L
K
N
L
L
AGGFG
G
V
C
L
V
F
VG------HP-------L
D
T
V
K
V
R
L
Q
TQPP-S----LP-G----Q--P--PM---YS-
G
T
-------
F
D
C
F
R
K
--------
T
L
F
-------
R
E-
G
I
T
G
L
--
Y
RG----MAAPI-IG
V
T
-------------
P
M
F
A
V
---
C
F
---------
F
---
G
F-G-
L
G
K
K
L
Q
Q
-------KH-------
P
E
-----
D
V
L
S
Y
P
Q
L
--
F
A
--------
A
---------------
G
M
L
S
G
V
F
TTGIMT
P
G
E
--
R
I
K
C
L
L
----------
Q
------
I
Q-ASSG------E-S--
K
Y
--------T
G
T
L
D
C
A
--
K
K
L
Y
Q
E
FGI
R
G
IYK--------------
G
T
V
L
T
L
M
R
D---VPA--S
G
------
M
Y
F
M
--
T
--
Y
E
W
L
K
N
-----IFTPE-GKRV--SELSA-
P
R
I
L
-------
V
AG--G
I
A
G
I
-----
F
NW---AVAI
P
P
D
V
L
K
S
R
-FQ--TAPPG----KY-P----
N
----
G
F
R
D
V
L
--
R
E
L
I
RDE------
G
V
T
S
L
Y
K
--------
G
F
N
A
V
M
I
R
AFP--------------------------A-N------
A
A
C
----
F
L
G
-
F
E
V
A
M
K
F
L
---NWATPNL------------------------------
6
PsiBlast_PDB
78.66
23%
-53
- C7 -
2C3E
4
ADT1_BOVIN
A:
[2-279]
-----------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
------
A
P
-------
I
E
R
V
K
L
L
L
Q
V
Q
H
A
-
S
----
K
Q
I
S
----
A
--
E
--
K
Q
---
Y
K
-
G
I
-------
I
D
C
V
V
R
--------
I
P
K
-------
E
Q
-
G
F
L
S
F
--
W
R
G
----
N
L
A
N
V
-
I
R
Y
F
-------------
P
T
Q
A
L
------------------
N
F
-
A
-
F
K
D
K
Y
K
Q
I
F
LGGVD
R
H
-------
K
Q
-----
F
W
R
Y
F
A
G
N
--
L
A
--------
S
---------------
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
----------
D
------
V
G
-
K
G
A
A
------
Q
-
R
--
E
F
--------
T
G
L
G
N
C
I
--
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
--------------
G
F
N
V
S
V
Q
G
I
---
I
I
Y
--
R
A
------
A
Y
F
G
--
V
--
Y
D
T
A
K
G
-----
M
L
-
P
D
-
P
K
N
V
--
H
I
I
V
S
-
W
M
I
A
Q
------
T
V
T
--
A
V
A
G
L
------------
V
S
Y
P
F
D
T
V
R
R
R
-
M
M
--
M
Q
S
G
R
----
K
G
-
A
----
D
IMYT
G
T
V
D
C
W
--
R
K
I
A
K
D
E
------
G
P
K
A
F
F
K
--------
G
A
W
S
N
V
L
R
G
M
G
--------------------------
G
-
A
------
F
V
L
----
V
L
Y
-
D
E
I
---------------------------------------------
5
PsiBlast_PDB
78.52
23%
-55
- C7 -
1OKC
10
ADT1_BOVIN
A:
[2-279]
-----------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
------
A
P
-------
I
E
R
V
K
L
L
L
Q
V
Q
H
A
-
S
----
K
Q
I
S
----
A
--
E
--
K
Q
---
Y
K
-
G
I
-------
I
D
C
V
V
R
--------
I
P
K
-------
E
Q
-
G
F
L
S
F
--
W
R
G
----
N
L
A
N
V
-
I
R
Y
F
-------------
P
T
Q
A
L
------------------
N
F
-
A
-
F
K
D
K
Y
K
Q
I
F
L
GGVD
R
H
-------
K
Q
-----
F
W
R
Y
F
A
G
N
--
L
A
--------
S
---------------
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
A
R
T
R
L
A
A
----------
D
------
V
G
-
K
G
A
A
------
Q
-
R
--
E
F
--------
T
G
L
G
N
C
I
--
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
--------------
G
F
N
V
S
V
Q
G
I
---
I
I
Y
--
R
A
------
A
Y
F
G
--
V
--
Y
D
T
A
K
G
-----
M
L
-
P
D
-
P
K
N
V
--
H
I
I
V
S
-
W
M
I
A
Q
------
T
V
T
--
A
V
A
G
L
------------
V
S
Y
P
F
D
T
V
R
R
R
-
M
M
--
M
Q
S
G
R
----
K
G
-
A
----
D
IMYT
G
T
V
D
C
W
--
R
K
I
A
K
D
E
------
G
P
K
A
F
F
K
--------
G
A
W
S
N
V
L
R
G
M
G
--------------------------
G
-
A
------
F
V
L
----
V
L
Y
-
D
E
I
---------------------------------------------
30
Fugue
77.64
22%
-61
* C7 *
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
------
A
P
-------
I
E
R
V
K
L
L
L
Q
V
Q
H
A
-
S
----
K
Q
-
I
S---
A
--
E
--
K
Q
---
Y
K
-
G
I
-------
I
D
C
V
V
R
--------
I
P
K
-------
E
Q
-
G
F
L
S
F
--
W
R
G
----
N
L
A
N
V
-
I
R
Y
F
-------------
P
T
Q
A
L
---
N
F
---------
A
---
F
K
-
D
-
K
Y
K
Q
I
F
L
GGVD---
R
H
-------
K
Q
-----
F
W
R
Y
F
A
G
N
--
L
A
--------
S
---------------
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
--
F
A
R
T
R
L
----------
A
------
A
D
-
V
G
K
G
------
A
-
A
QR
E
F
--------
T
G
L
G
N
C
I
--
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
--------------
G
F
N
V
S
V
Q
G
I
---
I
I
Y
--
R
A
------
A
Y
F
G
--
V
--
Y
D
T
A
K
G
-----
M
L
P
D
P
-
K
N
V
------
H
I
-
I
V
S
W
-------
M
I
A
--
Q
T
V
T
A
-----
V
A
G
---
L
V
S
Y
P
F
D
T
V
R
R
R
-
M
M
--
M
Q
S
G
R
----
K
G
-
A
DIMY
T
----
G
T
V
D
C
W
--
R
K
I
A
K
D
E
------
G
P
K
A
F
F
K
--------
G
A
W
S
N
V
L
R
G
M
G
--------------------------
G
-
A
------
F
V
L
----
V
L
Y
-
D
E
I
---------------------------------------------
21
HHSearch
76.15
22%
-61
- C7 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-----------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
T
A
V
------
A
P
-------
I
E
R
V
K
L
L
L
Q
V
Q
H
A
-
S
----
K
Q
-
I
S---
A
--
E
--
K
Q
---
Y
K
-
G
I
-------
I
D
C
V
V
R
--------
I
P
K
-------
E
Q
-
G
F
L
S
F
--
W
R
G
----
N
L
A
N
V
-
I
R
Y
F
-------------
P
T
Q
A
L
---
N
F
---------
A
---
F
K
-
D
-
K
Y
K
Q
I
F
L
-------
G
G
-------
V
D
RHKQ-
F
W
R
Y
F
A
G
N
--
L
A
--------
S
---------------
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
-----
L
D
F
A
R
----------
T
R
-----
L
A
-
A
D
V
G
KGAA--
Q
-
R
--
E
F
--------
T
G
L
G
N
C
I
--
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
--------------
G
F
N
V
S
V
Q
G
I
---
I
I
Y
--
R
A
------
A
Y
F
G
--
V
--
Y
D
T
A
K
G
-----
M
L
P
D
P
-
K
------
N
V
H
I
-
I
V
S
W
-------
M
I
A
--
Q
T
V
T
A
-----
V
A
G
---
L
V
S
Y
P
F
D
T
V
R
R
R
-
M
M
--
M
Q
S
G
R
KGAD
I
M
-
Y
----
T
----
G
T
V
D
C
W
--
R
K
I
A
K
D
E
------
G
P
K
A
F
F
K
--------
G
A
W
S
N
V
L
R
G
M
G
----------------------------
G
------
A
F
V
----
L
V
L
-
Y
D
E
I
--------------------------------------------
3
PsiBlast_PDB
69.95
26%
-49
- C7 -
4C9J
4
ADT3_YEAST
A:
[30-299]
-------------------------------------------------------------------------
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
------
S
P
-------
I
E
R
V
K
I
L
I
Q
N
Q
D
E
-
M
----
I
K
-
Q
----
G
TL
D
--
K
K
---
Y
S
-
G
I
-------
V
D
C
F
K
R
--------
T
A
K
-------
Q
E
-
G
L
I
S
F
--
W
R
G
----
N
T
A
N
V
-
I
R
Y
F
-------------
P
T
Q
A
L
---
N
F
A
F
K
D
K
I
K
L
M
F
---
G
F
-----
K
K
E
E
G
-------
Y
G
-------
K
W
-----
F
A
G
N
L
A
S
G
--
G
A
--------
A
---------------
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
--
R
L
A
A
D
A
----------
K
------
S
------------
A
-
R
--
Q
F
--------
N
G
L
T
D
V
Y
--
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
--------------
G
F
M
P
S
V
V
G
I
---
V
V
Y
--
R
G
------
L
Y
F
G
--
M
--
F
D
S
L
K
---------------------------
F
-------
L
L
G
--
W
V
V
T
T
-----
G
A
S
---
T
C
S
Y
P
L
D
T
V
R
R
R
M
M
M
--
T
S
G
Q
A
----
V
K
-
Y
----
N
----
G
A
I
D
C
L
--
K
K
I
V
A
S
E
------
G
V
G
S
L
F
K
--------
G
C
G
A
N
I
L
R
S
V
A
--------------------------
G
-
A
------
G
V
I
----
S
M
Y
-
D
Q
L
Q
M
I
L
F
---
G
K
K
F
---------------------------------
34
Fugue
64.55
16%
-72
- C5 -
4KXR
-
?
C:
[8-298]
------------------------------------------------------------
T
D
I
--
T
V
N
V
D
G
F
W
M
L
Q
A
L
L
-----------------
D
-------
I
R
H
V
A
P
E
L
R
C
R
P
Y
-
V
----
H
P
-
G
----
M
--
A
--
V
M
---
R
E
-
Q
G
-------
I
--
V
V
N
--------
D
A
V
-------
N
E
-
Q
V
A
A
R
--
M
K
V
----
L
A
A
P
D
-
L
E
V
V
-------------
A
L
L
S
R
---
G
K
---------
L
---
L
Y
-
G
V
I
D
D
E
N
Q
P
-------
P
G
-------
S
R
-----
D
I
P
D
N
E
F
R
--
V
V
--------
L
---------------
A
R
R
G
Q
H
W
V
S
A
V
R
V
-
G
N
--
D
I
T
-
V
D
----------
D
------
V
T
-
V
S
D
S
------
A
-
S
--
I
A
--------
A
L
V
M
D
G
L
--
E
S
I
H
--------
H
A
--------------
D
P
A
A
I
N
A
V
N
---
V
P
M
--
E
E
------
M
L
E
A
--
T
--
K
S
W
Q
E
S
-----
G
F
N
V
F
S
G
G
D
L
--
R
R
M
G
I
-
S
A
A
T
-------
V
A
A
--
L
G
Q
A
L
-----
S
D
P
---
A
A
E
V
A
V
Y
A
R
Q
Y
R
-
D
D
--
A
K
G
P
S
----
A
S
-
V
----
L
----
S
L
K
D
G
--------
S
G
------
G
R
I
A
L
Y
Q
--------
Q
A
R
E
A
W
L
A
I
C
P
--------------------------
A
T
P
------
Q
L
V
----
Q
V
G
-
V
K
T
V
L
D
T
L
PYG
E
W
K
T
H
S
-------------------------------
4
PsiBlast_PDB
64.37
26%
-53
- C7 -
4C9Q
5
ADT3_YEAST
A:
[30-299]
-------------------------------------------------------------------------
N
F
L
M
G
G
V
S
A
A
I
A
K
T
A
A
------
S
P
-------
I
E
R
V
K
I
L
I
Q
N
Q
D
E
-
M
----
I
K
-
Q
----
G
TL
D
--
K
K
---
Y
S
-
G
I
-------
V
D
C
F
K
R
--------
T
A
K
-------
Q
E
-
G
L
I
S
F
--
W
R
G
----
N
T
A
N
V
-
I
R
Y
F
-------------
P
T
Q
A
L
---
N
F
A
F
K
D
K
I
K
L
M
F
---
G
F
-----
K
K
E
-
G
-------
Y
G
-------
K
W
-----
F
A
G
N
L
A
S
G
--
G
A
--------
A
---------------
G
A
L
S
L
L
F
V
Y
S
L
D
F
A
R
T
--
R
L
A
A
D
A
----------
K
------
S
------------
A
-
R
--
Q
F
--------
N
G
L
T
D
V
Y
--
K
K
T
L
K
S
D
G
I
A
G
L
Y
R
--------------
G
F
M
P
S
V
V
G
I
---
V
V
Y
--
R
G
------
L
Y
F
G
--
M
--
F
D
S
L
K
P
-----
L
------------
F
L
A
S
----
F
-------
L
L
G
--
W
V
V
T
T
-----
G
A
S
---
T
C
S
Y
P
L
D
T
V
R
R
R
M
M
M
--
T
S
G
Q
A
----
V
K
-
Y
----
N
----
G
A
I
D
C
L
--
K
K
I
V
A
S
E
------
G
V
G
S
L
F
K
--------
G
C
G
A
N
I
L
R
S
V
A
--------------------------
G
-
A
------
G
V
I
----
S
M
Y
-
D
Q
L
Q
M
I
L
F
---
G
K
-----------------------------------
2
PsiBlast_PDB
64.37
26%
-61
- C7 -
4C9H
5
ADT2_YEAST
A:
[24-294]
-----------------------------------------------------------------------
L
I
D
F
L
M
G
G
V
S
A
A
V
A
K
T
A
A
------
S
P
-------
I
E
R
V
K
L
L
I
Q
N
Q
D
E
-
M
----
L
K
------
Q
--
G
--
T
L
DRK
Y
A
-
G
I
-------
L
D
C
F
K
R
--------
T
A
T
-------
Q
E
-
G
V
I
S
F
--
W
R
G
----
N
T
A
N
V
-
I
R
Y
F
-------------
P
T
Q
A
L
---
N
F
A
F
K
D
K
I
K
A
M
F
---
G
F
-----------------
K
K
-------
E
E
--------
G
Y
A
K
W
--
F
A
G
N
L
A
S
G
G
A
A
---------------
G
A
L
S
L
L
F
V
Y
S
L
D
Y
A
R
T
--
R
L
A
A
D
S
------------------------------
A
-
R
--
Q
F
--------
N
G
L
I
D
V
Y
--
K
K
T
L
K
S
D
G
V
A
G
L
Y
R
--------------
G
F
L
P
S
V
V
G
I
---
V
V
Y
--
R
G
------
L
Y
F
G
--
M
--
Y
D
S
L
K
---------------
L
--
A
S
F
L
L
-
G
W
V
V
-------
T
T
G
--
A
S
--------------
T
C
S
Y
P
L
D
T
V
R
R
R
-
M
M
M
T
S
G
Q
A
V
----
K
Y
-
D
----
G
----
A
F
-
D
C
L
--
R
K
I
V
A
A
E
------
G
V
G
S
L
F
K
--------
G
C
G
A
N
I
L
R
G
V
A
--------------------------
G
-
A
------
G
V
I
----
S
M
Y
-
D
Q
L
Q
M
I
L
F
---
G
K
K
F
K
--------------------------------
1
PsiBlast_PDB
63.85
26%
-67
- C7 -
2LCK
-
UCP2_MOUSE
A:
[16-292]
-------------------------------------------------------------------------
K
F
L
G
A
G
T
A
A
C
I
A
D
L
I
T
------
F
P
-------
L
D
T
A
K
V
R
L
Q
I
Q
G
E
-
S
QG
L
V
R
T
-
A
----
A
--
S
--
A
Q
---
Y
R
-
G
V
-------
L
G
T
I
L
T
--------
M
V
R
-------
T
E
-
G
P
R
S
L
--
Y
N
G
----
L
V
A
----
G
L
Q
-------------
R
Q
M
S
F
---
A
S
---------
V
---
R
I
-
G
-
L
Y
D
S
V
K
Q
F
Y
T
----
K
G
-------
S
E
-----
H
A
G
I
G
S
R
L
--
L
A
------------------------
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
--
V
V
K
V
R
F
----------
Q
------
A
Q
-
A
R
A
G
------
G
G
R
--
R
Y
--------
Q
S
T
V
E
A
Y
--
K
T
I
A
R
E
E
G
I
R
G
L
W
K
--------------
G
T
S
P
N
V
A
R
N
---
A
I
V
--
N
C
------
A
E
L
V
--
T
--
Y
D
L
I
K
D
-----
T
L
L
K
A
-
N
L
M
T
--
D
D
L
---
P
C
H
F
-------
T
S
A
--
F
G
A
G
F
-----
C
T
T
---
V
I
A
S
P
V
D
V
V
K
T
R
-
Y
M
--
N
S
A
L
G
----
Q
Y
-
H
----
S
----
A
G
H
C
A
L
---
T
M
L
R
K
E
------
G
P
R
A
F
Y
K
--------
G
F
M
P
S
F
L
R
L
G
S
--------------------------
W
-
N
------
V
V
M
----
F
V
T
-
Y
E
Q
L
K
R
A
L
---
M
A
A
Y
Q
S
R
------------------------------
20
HHSearch
62.44
24%
-62
- C7 -
2LCK
-
UCP2_MOUSE
A:
[14-303]
-----------------------------------------------------------------------
T
V
K
F
L
G
A
G
T
A
A
C
I
A
D
L
I
T
------
F
P
-------
L
D
T
A
K
V
R
L
Q
I
Q
G
E
-
S
----
Q
G
-
L
V
R
T
A
A
--
S
--
A
Q
---
Y
R
-
G
V
-------
L
G
T
I
L
T
--------
M
V
R
-------
T
E
-
G
P
R
S
L
--
Y
N
G
----
L
V
A
G
L
-
Q
R
Q
M
-------------
S
F
A
S
V
---
R
I
---------
G
---
L
Y
-
D
-
S
V
K
Q
F
Y
T
-------
K
G
--------
S
-----
E
H
A
G
I
G
S
R
--
L
L
--------
A
---------------
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
--
V
V
K
V
R
F
----------
Q
------
A
Q
A
R
A
G
G
------
G
-
R
--
R
Y
--------
Q
S
T
V
E
A
Y
--
K
T
I
A
R
E
E
G
I
R
G
L
W
K
--------------
G
T
S
P
N
V
A
R
N
---
A
I
V
--
N
C
------
A
E
L
V
--
T
--
Y
D
L
I
K
D
-----
T
L
L
K
A
-
N
L
M
----
T
D
D
L
-
P
C
H
F
-------
T
S
A
--
F
G
A
G
F
-----
C
T
T
---
V
I
A
S
P
V
D
V
V
K
T
R
-
Y
M
--
N
S
A
L
-----
G
Q
-
Y
----
H
----
S
A
G
H
C
A
--
L
T
M
L
R
K
E
------
G
P
R
A
F
Y
K
--------
G
F
M
P
S
F
L
R
L
G
S
--------------------------
W
-
N
------
V
V
M
----
F
V
T
-
Y
E
Q
L
K
R
A
L
---
M
A
A
Y
Q
S
R
------------------------------
31
Fugue
59.78
17%
-76
* C8 *
4ZFV
2
?
A:
[10-445]
N
V
L
D
F
T
V
L
G
L
N
S
G
TSMD
G
I
D
C
A
L
C
H
F
Y
Q
KTPDA
P
M
E
F
E
LL
E
Y
G
E
V
P
LA
Q
P
I
K
Q
R
V
M
R
M
I
L
E
D
T
TS
P
S
E
L
S
E
V
N
V
I
L
G
E
H
F
A
D
A
V
R
Q
F
A
A
E
R
NVDL
S
T
-------
I
D
A
I
A
S
H
G
Q
T
I
W
L
L
S
----
M
P
-
E
----
E
--
G
--
Q
V
---
K
S
-
A
L
-------
T
M
A
E
G
A
--------
I
L
A
-------
S
R
T
G
I
T
S
I
T
D
F
R
I
----
S
D
Q
A
A
-
G
R
Q
G
-------------
A
P
L
I
A
---
F
F
---------
D
---
A
L
-
L
-
L
H
H
P
T
K
L
-------
R
A
-------
C
Q
-----
N
I
G
G
I
A
N
V
--
C
F
I
P
P
DV---
D
---------------
G
R
R
T
D
E
Y
Y
D
F
D
T
G
P
G
N
--
V
F
I
D
A
V
----------
V
------
R
H
-
F
T
N
G
------
E
-
Q
--
E
Y
DKDG
A
M
G
K
R
G
K
V
D
----
Q
E
L
V
D
D
F
L
K
M
P
Y
F
Q
LDPPKTTGREVFRD
T
L
A
H
D
L
I
R
R
---
A
E
A
--
K
G
LS
P
D
D
I
V
A
T
T
--
T
--
R
I
T
A
Q
A
-----
I
V
D
H
Y
-
R
R
Y
A
--
P
S
Q
E
I
-
D
E
I
F
-------
M
C
G
--
G
G
A
Y
N
-----
P
N
I
---
V
E
F
I
Q
Q
S
Y
P
N
T
K
-
I
M
--
M
L
D
E
A
----
G
V
-
P
-------------------
A
G
A
K
E
------
A
I
T
F
A
W
Q
--------
G
M
E
A
L
V
G
R
S
I
P
V
P
T
RVETRQHYV
L
G
K
V
S
P
G
LN
Y
R
S
V
M
K
-
K
------
G
M
A
----
F
G
G
-
D
A
Q
Q
L
P
W
V
---
S
E
M
I
V
K
K
KG
K
V
I
T
NNWAGSHHHH--------------
23
HHSearch
58.98
25%
-66
- C7 -
1OKC
8
ADT1_BOVIN
A:
[4-204]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
F
L
K
D
--
F
L
--------
A
---------------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
--
R
V
K
L
L
L
------------------
Q
-
V
Q
H
A
SKQISA
E
-
K
--
Q
Y
--------
K
G
I
I
D
C
V
--
V
R
I
P
K
E
Q
G
F
L
S
F
W
R
--------------
G
N
L
A
N
V
I
R
Y
---
F
P
T
--
Q
A
------
L
N
F
A
--
F
--
K
D
K
Y
K
Q
-----
I
F
L
G
G
-
V
D
R
H
KQ
F
W
R
Y
F
-
A
G
N
L
-------
A
S
G
--
G
A
A
G
A
-----
T
S
L
---
C
F
V
Y
P
L
D
F
A
R
T
R
-
L
A
--
A
D
V
G
K
GAAQ
R
E
-
F
----
T
----
G
L
G
N
C
I
--
T
K
I
F
K
S
D
------
G
L
R
G
L
Y
Q
--------
G
F
N
V
S
V
Q
G
I
I
I
--------------------------
Y
-
R
------
A
A
Y
----
F
G
V
-
Y
D
T
A
K
G
M
L
---
P
D
P
K
N
V
H
------------------------------
32
Fugue
58.50
19%
-98
- C1 -
4WW4
1
?
A:
[3-458]
------------------QISE
V
R
G
N
T
RDHRTAAHTHIKGLGLNSSGIAEKQAAGFVGQ
C
A
A
R
--
E
A
C
G
V
V
V
D
L
I
K
A
H
K
M
A
G
R
G
V
L
L
A
G
------
G
P
GTG
K
T
A
L
A
L
A
I
S
Q
E
L
G
T
K
I
P
-
F
----
C
P
-
I
T
---
G
--
S
--
E
I
---
Y
S
-
T
E
VK
K
T
E
V
L
M
E
N
F
R
R
A
I
------
G
L
R
-------
V
R
-
E
T
K
D
V
--
Y
E
G
----
E
V
S
T
L
L
I
G
L
K
S
ARGQKLDQKERV
Q
V
G
D
V
---
I
Y
---------
I
---
E
T
-
N
-
T
G
A
C
R
S
D
-------
A
Y
-------
A
T
-----
E
F
D
L
E
A
E
E
--
Y
V
--------
P
---------------
I
P
K
G
E
V
H
K
K
K
E
I
V
Q
D
V
--
T
L
H
D
L
D
----------
V
------
A
N
-
A
R
P
D
------
I
-
I
--
S
M
--------
M
G
Q
L
M
K
P
--
K
M
T
E
I
T
D
K
L
R
M
E
I
N
--------------
K
V
V
Q
K
Y
I
N
Q
GVA
E
L
I
--
P
G
------
V
L
F
I
--
D
EA
H
M
L
D
I
E
-----
C
F
T
Y
L
-
N
K
A
L
--
E
S
P
I
A
-
P
I
V
V
-------
L
A
S
NR
G
I
A
T
I
RGADD
L
K
A
---
A
H
G
I
P
P
D
F
L
Q
-
R
-
L
L
--
I
I
P
T
H
----
P
Y
E
P
----
D
----
E
I
R
R
I
V
--
R
I
R
A
Q
T
E
------
G
V
Q
L
T
D
A
--------
A
V
D
R
V
A
E
H
G
V
R
--------------------------
I
-
S
------
L
R
Y
----
C
L
Q
L
L
A
P
A
S
I
L
A
---
R
V
N
G
R
T
Q
VD
V
Q
D
I
A
E
A
E
E
L
F
LD
A
R
R
S
A
N
I
L
T
S
TGGLH
38
Fugue
55.35
22%
-65
- C4 -
4PWO
1
?
A:
[1-250]
------------------------------------------------------------
T
Q
A
--
E
K
T
A
T
D
L
P
P
G
F
S
G
K
A
G
S
V
---------------------------
N
A
T
P
G
T
K
-
G
----
L
D
-
G
----
P
--
T
--
P
L
---
A
D
-
G
S
-------
F
D
A
-----------
T
I
F
-------------------
G
----
P
A
K
E
L
-
K
S
A
D
-------------
D
I
L
N
V
----------------------------
H
R
-------
R
N
-------
A
K
-----
D
P
--------
F
A
--------
V
---------------
G
A
V
D
A
P
----------------
L
V
----------
I
------
T
E
-
F
S
D
F
------
E
-
C
--
P
F
--------
C
A
R
W
S
N
Q
T
E
P
T
L
M
E
E
Y
----
V
S
K
--------------
G
L
V
R
I
E
W
N
D
---
L
P
V
--
N
G
--------------------------------
E
H
A
L
--
A
A
A
K
A
-
G
R
A
A
-------
A
A
Q
--
G
K
F
D
E
-----
F
R
K
---
A
L
F
E
A
S
R
------------
N
V
S
----
G
H
-
P
----
N
----
N
T
L
K
D
F
--
E
R
F
A
R
N
A
------
G
V
K
D
M
E
R
F
S
R
E
A
Q
DS
T
Y
D
E
V
L
A
K
A
A
D
--------------------------
Y
-
A
------
H
G
L
GVSG
T
P
A
-
F
V
V
G
T
Q
Y
I
---
S
G
A
Q
P
T
E
E
F
I
K
V
I
E
S
E
L
K
K
SP
T
F
S
T
PSSH--------
39
Fugue
53.09
18%
-82
- C6 -
4PEI
4
?
A:
[7-355]
---------------------------------------------Q
I
Q
H
I
A
I
V
G
S
VHGK
Y
R
E
M
--
Y
R
Q
L
S
E
Y
E
K
S
T
-----
G
K
E
I
S
F
V
I
------
C
T
-------
G
D
M
Q
T
L
R
Y
E
A
D
L
V
-
Y
----
L
K
-
V
----
P
--
P
--
K
Y
---
K
Q
M
G
D
-------
F
H
L
Y
Y
E
GKEKAPYL
T
L
F
I
G
G
NHES
S
N
-
V
L
L
H
L
--
Y
N
G
GFVC
F
N
M
Y
Y
-
L
G
V
C
-------------
S
C
I
N
I
NG
L
R
I
---------
V
---
G
V
S
G
-
I
Y
K
S
F
D
E
-------
K
K
P
Y
T
Y
PPS
P
N
-----
D
V
V
S
L
F
H
T
RN
Y
V
--------
I
---------------
Q
M
L
S
N
------
L
S
Q
S
S
--
Q
I
D
I
S
L
----------
S
HDWPQG
I
V
-
M
K
G
N
------
Y
-
K
--
Q
L
--------
Y
R
F
Q
P
G
F
--
K
K
D
G
A
S
L
G
S
-
P
I
N
K
--------------
V
I
L
N
T
L
K
P
K
---
Y
W
I
--
S
G
------
H
M
H
C
--
E
--
Y
H
A
E
E
G
P
T
---
H
F
I
A
L
-
G
K
I
G
--
Y
K
N
A
I
-
S
Y
L
D
-------
L
P
L
--
K
Q
K
T
D
-----
L
E
Y
---
D
K
D
W
V
C
N
L
I
M
T
W
-
P
A
--
F
S
N
K
A
----
Q
F
-
P
----
D
LSY-
S
I
S
E
L
L
S
K
R
T
K
E
L
D
K
------
K
I
I
E
L
W
E
--------
K
Y
I
G
L
K
I
I
Y
D
S
--------------------------
D
-
T
--------
F
----
D
I
Q
-
F
T
S
R
R
F
Y
I
---
E
K
I
Y
N
E
L
NI----------------------------
22
HHSearch
44.60
26%
-58
- C7 -
2LCK
-
UCP2_MOUSE
A:
[113-302]
-------------------------------------------------------------------
H
A
G
I
G
S
R
L
L
A
G
S
T
T
G
A
L
A
V
A
V
A
------
Q
P
-------
T
D
V
V
K
V
R
F
Q
A
Q
A
R
-
A
----
G
G
---------
G
--
R
R
---
Y
Q
-
S
T
-------
V
E
A
Y
K
T
--------
I
A
R
-------
E
E
-
G
I
R
G
L
--
W
K
G
----
T
S
P
N
V
-
A
R
N
A
-------------
I
V
N
C
A
---
E
L
---------
V
---
T
Y
-
D
-
L
I
K
D
T
L
L
-------
K
A
-------
N
L
-----
M
T
D
D
L
P
C
H
--
F
T
--------
S
---------------
A
F
G
A
G
F
C
T
T
V
I
A
S
P
-----
V
D
V
V
K
----------
T
R
-----
Y
M
-
N
S
A
-------
L
-
G
--
Q
Y
--------
H
S
A
G
H
C
A
--
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
--------------
G
F
M
P
S
F
L
R
L
---
G
S
W
--
N
V
------
V
M
F
V
--
T
--
Y
E
Q
L
K
R
-----
A
L
M
A
A
-
Y
Q
S
R
--
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
44.56
20%
-93
- C7 -
3WX4
-
ARN_BPT4
A:
[1-98]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------
I
I
-
D
S
Q
S
------
V
-
V
--
Q
Y
--------
T
F
K
I
D
I
L
--
E
K
L
Y
K
F
--
L
P
N
L
Y
H
--------------
S
I
V
N
E
L
V
E
E
---
L
H
L
E
N
N
D
------
F
L
I
G
--
T
--
Y
K
D
L
S
K
AG
Y
F
Y
V
I
P
A
P
-
G
K
N
I
--
D
D
V
L
K
-
T
I
M
I
-------
Y
V
H
D
Y
E
I
E
D
Y
-----
F
E
L
---
E
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
41.69
11%
-55
- C8 -
1WKV
1
CYSO_AERPE
A:
[2-383]
----------------------------------------------ALADISGYLDVLD
S
V
R
G
--
F
S
Y
L
E
N
A
R
E
V
L
R
S
G
-
E
A
R
C
L
G
N
P
R
------
S
E
-------
P
E
Y
V
K
A
L
Y
V
I
G
A
S
-
R
----
I
P
-
V
----
G
--
D
G
C
S
H
---
T
L
-
E
E
-------
L
G
V
F
D
I
--------
S
V
P
-------
G
E
-
M
V
F
P
S
--
P
L
D
----
F
F
E
R
G
--
K
P
T
-------------
P
L
V
R
S
---
R
L
---------
Q
L
P
N
G
V
-
R
-
V
W
L
K
L
E
W
-------
Y
N
-------
P
F
SLSVK
D
R
P
A
V
E
I
I
--
S
R
--------
L
SRRVEKGSLV
A
D
A
T
S
S
N
F
G
V
A
L
S
A
V
A
R
L
Y
G
Y
--
R
A
R
V
Y
L
P
GAAE
E
F
G
K
L
L
------
P
R
-
L
L
G
A
------
Q
-
V
--
I
V
--------
D
P
E
A
P
S
T
--
V
H
L
L
P
R
V
M
K
D
S
K
N
E
--------------
G
F
V
H
V
N
Q
F
Y
---
N
D
A
--
N
F
------
E
A
H
M
R
G
T
--
A
R
E
I
F
V
-----
Q
S
R
R
G
-
G
L
A
L
--
R
G
V
A
G
-
S
-
L
G
-------
T
S
G
--
H
M
S
A
A
-----
A
F
Y
---
L
Q
S
V
D
P
S
I
-
R
A
V
-
L
V
--
Q
P
A
Q
G
----
D
S
-
I
----
P
----
G
I
R
R
V
E
--
T
G
M
L
W
I
N
MLD
I
S
Y
T
L
A
E
V
T
L
--------
E
E
A
M
E
A
V
V
E
V
A
--------------------------
R
-
S
DG
L
V
I
G
P
S
G
----
G
A
A
-
V
K
A
L
A
K
K
A
---
A
E
G
D
L
E
P
G
D
Y
V
V
V
V
PDTGFKY
L
S
L
V
Q
N
A
L
E-------
7
PsiBlast_PDB
39.67
26%
-50
- C7 -
1TFF
-
OTUB2_HUMAN
A:
[12-123]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------
C
D
I
L
S
I
L
R
D
---
H
P
E
--
N
R
------
I
Y
R
R
--
K
--
I
E
E
L
S
K
-----
R
F
T
A
I
-
R
K
T
K
--
G
D
R
N
C
F
Y
R
A
L
G
Y
S
Y
L
E
S
L
L
G
--
K
S
R
E
I
-----
F
K
F
K
E
R
V
L
Q
T
P
N
D
L
L
A
A
G
-
F
E
--
E
H
K
F
R
----
N
F
-
F
----
N
----
A
F
Y
S
V
V
--
E
L
V
E
K
D
G
------
S
V
S
S
L
L
K
--------
V
F
N
D
Q
S
A
S
D
H
I
--------------------------
V
-
Q
------
F
L
R
----
L
L
T
-
S
A
F
I
R
N
R
A
---
D
F
F
R
H
F
I
------------------------------
26
HHSearch
39.25
22%
-43
- C7 -
3VJJ
-
?
A:
[273-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----
L
A
T
---
F
D
N
Y
P
F
D
L
L
R
F
Q
-
L
S
--
S
L
I
S
-------------------
T
P
A
L
I
--
R
E
K
I
A
K
E
------
G
L
F
K
I
I
T
--------
T
V
L
F
R
G
I
N
G
S
E
--------------------------
S
-
F
------
L
N
I
----
K
R
Y
-
R
K
F
K
T
R
I
V
---
G
N
V
D
C
V
I
------------------------------