@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MFSD5_HUMAN: (2015-12-08 )
MLVTAYLAFVGLLASCLGLELSRCRAKPPGRACSNPSFLRFQLDFYQVYFLALAADWLQAPYLYKLYQHYYFLEGQIAILYVCGLASTVLFGLVASSLVDWLGRKNSCVLFSLTYSLCCLTKLSQDYFVLLVGRALGGLSTALLFSAFEAWYIHEHVERHDFPAEWIPATFARAAFWNHVLAVVAGVAAEAVASWIGLGPVAPFVAAIPLLALAGALALRNWGENYDRQRAFSRTCAGGLRCLLSDRRVLLLGTIQALFESVIFIFVFLWTPVLDPHGAPLGIIFSSFMAASLLGSSLYRIATSKRYHLQPMHLLSLAVLIVVFSLFMLTFSTSPGQESPVESFIAFLLIELACGLYFPSMSFLRRKVIPETEQAGVLNWFRVPLHSLACLGLLVLHDSDRKTGTRNMFSICSAVMVMALLAVVGLFTVVRHDAELRVPSPTEEPYAPEL
Atome Classification :
(20 SA)
------------------------------------------......-----------...10..---.--....--.20.-----.......30........40........50-----------........---60.......-.-70--.......---.80--------.........90........-----100..--------------------------.......------110..---.-------....-120...-----..-..-----------------------------.130.......140------------..----......150...-....160-.......170..-...---..--------------180.......190..--------------------------.-....200----....-----..-..----.210--.-..--.-.--..220----.......----.-.--230---.......--.-240..-----.....250......------------------.260......----.270-..-.-------.-.----.---.280-.---........290.--......300.......-----310.....-....320.....-..330.......340---..--.....350..---.....360.......---370--------.......380---........-390-----.....----------------.----..400.-..-.....--410..-------....----.420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------M
L
V
T
A
Y
-----------
L
A
F
V
G
L
L
---
A
--
S
C
L
G--
L
E
L
S
-----
R
CRAKPPGRACSNP
S
F
L
R
F
Q
L
D
F
Y
Q
V
Y
F
L
-----------
A
L
A
A
D
W
LQ---A
P
Y
L
Y
K
L
Y
Q
-
H
-
Y
Y
--FLEG
Q
I
A
---
I
L
---------
Y
V
C
G
L
A
S
T
V
L
F
G
L
V
A
S
S
L
V
-----
D
--
W
L--------------------------GRKN
S
C
V
------
L
F
S
L
T
---
Y
-------
S
L
C
C
-
L
-
T
KLS-----Q
D
-
Y
F
-----------------------------
V
L
L
V
G
R
A
LG
G
L
S
T
-------------
A
L
----
L
F
S
A
F
E
A
W
Y
I
H
E
-
H
V
E
RHDF-
P
A
E
W
I
P
A
T
F
A
R
A
-
A
F
W
---
N
H
--------------
V
L
A
V
V
A
G
V
A
A
E
A
V
A
S
--------------------------
W
-IGLG
P
------
V
A
P
F
-----
V
A
-
A
I
----
P
L
L
A
--
L
-
A
G
--
A
-
L
--
A
L
R
------NWGEN
Y
D
----
R
-
Q
--
R
-
A
---
F
S
R
T
C
A
G
--
G
-
L
R
C
L
L-----SDR
R
V
L
L
L
G
T
I
Q
A
L
------------------
F
E
S
V
I
F
I
F
V
F
----
L
WTP-VL-D-------P-H----G---A
P
---
L
---
G
I
I
F
S
S
F
M
A
A
S
L
--
L
G
S
S
L
Y
R
IATSKRYHL-----
Q
--
P
M
H
L
L
-
S
L
A
V
L
I
V
V
F
S
L
F
-
M
L
TFSTSPGQES
P
V
E
---
S
F
--
I
A
F
L
L
I
E
L
A
C
---
G
LYFP
S
M
S
F
L
R
R
KVI---PET--------EQAG
V
L
N
W
F
----
R
V
P
L
H
S
L
A
-
C
-
L
-----
G
L
L
V
L
----------------H----DSDR-K-TG-
T
R
N
M
F
--
S
I
C
S
A
-------
V
M
V
M
----
A
L
L
A
V
V
G
L
F
T
V
V
RHDAELRVPSPTEEPYAPEL
8
Fugue
88.03
16%
-131
- C2 -
2HCN
-
A:
[12-582]
-----------------------------------LVN
G
V
V
R
L
L
S
K
P
W
DTITTKAPEPP
E
G
V
K
Y
V
L
---
N
--
E
T
T
N
--
W
L
W
A
-----
F
L
A
R
E
K
R
P
R
M
C
S
R
E
E
F
I
R
K
V
N
S
N
A
A
Q
W
-------------
R
S
A
R
E
A
V
E
---
D
P
K
F
W
E
M
V
D
-
E
-
E
R
E
A
H
L
R
G
E
C
H
TCR
A
I
---------
W
F
M
W
L
G
A
R
F
L
E
F
E
A
L
G
F
L
N
-----
E
DH
W
L
--------------------------
G
R
K
N
S
G
G
GVEGLG
L
Q
K
L
G
---
Y
-------
I
L
R
E
-
V
-
G
T
R
P
-----
G
G
-
R
I
-----------------------------
Y
A
D
D
T
A
G
W
D
T
R
I
T
-------------
R
A
----
D
L
E
N
E
A
K
V
L
E
L
L
-
D
G
E
H
R
R
L
-
A
R
A
I
I
E
L
T
Y
R
S
G
-
Q
V
V
---
T
Y
--------------
A
L
N
T
F
T
N
L
A
V
Q
L
V
R
M
--------------------------
M
-
E
G
E
G
V
------
I
G
P
-------
D
-
D
V
----
E
K
L
T
--
K
-
G
K
--
G
-
P
--
K
V
R
------
T
W
L
S
E
N
G
----
E
-
E
--
R
-
L
----
S
R
M
A
V
S
--
G
-
D
D
C
V
V
K
P
L--
D
D
R
F
A
T
S
L
H
F
L
N
A
M
SKVRKDIQEWK
P
S
T
G
W
YD
W
Q
Q
V
P
F
C
S
N
H
----
F
T
E
L
-
I
M
-
K
DG
R
T
L
V
T
P
-
C
----
R
---
G
Q
---
D
---
E
L
V
G
R
A
R
I
S
P
N
V
--
R
D
T
A
C
L
A
K
S
Y
A
Q
M
W
L
L
LYFHR
R
--
D
L
R
L
M
-
A
N
A
I
C
S
A
V
P
V
N
W
-
V
P
T
G
R
T
T
W
S
I
H
A
G
G
E
---
W
M
--
T
T
E
D
M
L
E
V
W
N
---
R
V
W
I
E
E
N
E
W
M
E
D
K
------------------
T
P
V
E
K
W
S
----
D
V
P
Y
S
G
-----
K
-----
R
E
D
I
W
----------------
C
----
G
S
L
I
-
G
-
T
R
-
A
R
A
T
W
--
A
E
N
I
Q
-------
V
A
I
N
----
Q
V
R
S
I
I
G
D
E
K
Y
V
D
Y
M
S
S
L
K
-------------
15
HHSearch
79.23
16%
-145
* C2 *
3WDO
-
?
A:
[16-383]
--------------------------------------------------------------------------------------------------------------
G
T
V
F
S
L
-----------
R
M
L
G
M
F
M
V
---
L
P
V
L
T
T
Y
G
M
A
L
-
Q
G
--
A
S
E
A
L
I
G
---
I
A
---------
I
G
I
Y
G
L
T
Q
A
V
F
Q
I
P
F
G
L
L
S
-----
D
--
R
I
--------------------------
G
R
K
P
L
I
V
------
G
G
L
A
V
---
F
-------
A
A
G
S
V
I
-
A
A
L
S
-----
D
S
-
I
W
-----------------------------
G
I
I
L
G
R
A
L
Q
G
S
G
A
-------------------
I
A
A
A
V
M
A
L
L
S
D
L
-------
T
-
R
E
Q
N
R
T
K
A
M
A
F
I
-
G
V
S
---
F
G
--------------
I
T
F
A
I
A
M
V
L
G
P
I
I
T
H
--------------------------
K
-
L
G
L
H
A
--------
L
F
-----
W
M
-
I
A
----
I
L
A
T
T
G
I
A
L
T
--
I
-
W
--
V
V
P
------
N
S
S
T
H
V
L
----
N
-
R
--------
E
S
G
M
V
K
G
--
S
-
F
S
K
V
L
-----
A
E
P
R
L
L
K
L
N
F
G
I
M
C
------------------
L
H
M
L
L
M
-
S
T
F
----
V
A
L
P
-
G
Q
L
A
-------
D
-
A
----
G
---
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
S
V
--
V
P
F
I
I
Y
A
E
V
K
-
R
K
M
-------
K
--
Q
--
V
F
-
V
F
C
V
G
L
I
V
V
A
E
I
-
V
L
W
N
A
Q
----
T
Q
F
W
Q
---
L
V
--
V
G
V
Q
L
F
F
V
A
F
---
N
L
M
E
A
L
L
P
S
L
I
S
K
E
S
---
P
A
G
--------
Y
K
G
T
A
M
G
V
Y
----
S
T
S
Q
F
L
G
V
-
A
-
I
-----
G
G
S
L
G
----------------
G
----
W
I
D
G
-
M
-
F
D
-
G
Q
G
V
F
--
L
A
G
A
M
-------
L
A
A
V
----
W
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
14
Fugue
77.25
19%
-126
- C2 -
4PEI
4
?
A:
[7-355]
--------------------------------------------
Q
I
Q
H
-----------
I
A
I
V
G
--------
S
V
H
G
K
Y
R
E
M
Y
-----
R
Q
L
S
E
Y
E
K
S
T
G
K
E
I
S
F
V
I
C
T
G
D
M
Q
T
L
R
Y
E
-----------
A
D
L
V
Y
L
K
V
---
P
P
K
Y
K
Q
M
G
D
-
F
-
H
L
--
Y
Y
E
G
K
E
K
---
A
P
---------
Y
L
----
T
L
F
I
G
G
N
H
E
S
S
N
V
-----
L
--
L
H
--------------------------
L
Y
N
G
G
F
V
------
C
F
N
M
Y
---
Y
----------------
L
G
-----
V
C
-
S
C
-----------------------------
I
N
I
N
G
L
R
I
V
G
V
S
G
-------------------
I
Y
K
S
F
D
-----------
E
K
K
-
P
Y
T
Y
P
P
S
P
N
D
V
V
-
S
L
F
HTR
N
Y
--------------
V
I
Q
M
L
S
N
L
S
Q
S
S
Q
I
D
----------------------------
I
S
L
S
H
------
D
W
P
-----------------------
Q
G
--
I
-
V
--
M
K
G
------
N
Y
K
Q
L
Y
R
----
F
-
Q
--
P
-
G
---
F
K
K
D
G
A
S
-------
L
G
-----
S
P
I
N
K
V
I
L
N
T
L
K
P
---------------------------------------------------------------------
K
Y
W
I
S
G
H
M
H
C
----------------
E
Y
H
A
-----
E
E
G
P
T
H
F
I
-
A
L
G
K
--
I
G
Y
K
N
A
-
I
S
Y
L
D
L
P
L
K
Q
K
T
D
L
E
YD
K
D
W
--
V
C
N
L
I
M
T
W
P
A
FSN
K
A
Q
F
P
D
L
S
Y
S
I
S
E
L
L
S
K
R
T
K
E
--------
L
D
K
K
I
I
E
L
W
----
E
K
Y
I
-------------
G
L
K
I
I
----------------
Y
----
D
S
D
T
----------------------------
F
----
D
I
Q
F
T
S
R
R
F
Y
I
E
K
I
Y
N
E
L
N
I
------------
10
Fugue
77.23
17%
-133
- C2 -
4ZFV
2
?
A:
[10-445]
--------------------------------------------
N
V
L
D
-----------
F
T
V
L
G
L
N
---
S
G
T
S
M
D
G
--
I
D
C
A
-----
L
C
H
F
Y
Q
K
----
T
P
D
A
P
M
E
F
E
L
L
E
Y
G
E
V
P
L
-----------
A
--
Q
P
I
K
Q
---
R
V
M
R
M
I
L
E
D
-
T
-
T
S
--
P
S
E
L
S
E
V
---
N
V
---------
I
L
G
E
H
F
A
D
A
V
R
Q
F
A
A
E
R
N
V
-----
D
---
L
--------------------------
S
T
I
D
A
I
A
------
S
H
G
Q
T
---
I
-------
W
L
L
S
-
M
-
P
E
E
G
-----
Q
V
-
K
S
-----------------------------
A
L
T
M
A
E
G
A
I
L
A
S
R
-------------
T
G
----
I
T
S
I
T
D
F
R
I
S
D
Q
-
A
A
G
R
Q
G
A
-
P
L
----
I
A
F
F
D
A
-
L
L
L
---
H
H
--------------
P
T
K
L
R
A
C
Q
N
I
G
G
I
A
N
--------------------------
V
-
C
F
I
P
P
DVDGRR
T
D
E
Y
-----
Y
D
-
F
D
TGPG
N
V
F
I
--
D
-
A
V
--
V
-
R
--
H
F
T
------
N
G
E
Q
E
Y
D
----
K
-
D
--
G
-
A
---
M
G
K
R
G
K
V
--
D
----------------------
Q
E
L
------------------
V
D
D
F
L
K
M
P
Y
F
----
Q
-----
L
-
D
-------
P
-
P
----
K
---
T
T
---
G
---
R
E
V
F
R
D
T
L
A
H
D
L
--
I
R
R
A
E
A
K
-------
G
L
-----
S
--
P
D
D
I
V
-
A
T
T
T
R
I
T
A
Q
A
I
V
-
D
H
Y
R
R
Y
A
P
S
Q
E
I
D
-
E
---
I
F
--
M
C
------
G
G
---
G
A
Y
N
P
N
I
V
E
F
I
Q
Q
S
Y
---
P
N
T
---------
K
I
M
M
L
D
E
A
----
G
V
P
A
G
A
K
E
-
A
-
I
T
F
A
W
Q
G
M
E
A
L
V
GRSI
P
V
P
T
RVETRQH
Y
----
V
L
G
K
-
V
-
S
P
-
G
L
N
Y
R
--
S
V
M
K
K
-------
G
M
A
F
GGDA
Q
Q
L
P
W
V
S
E
M
I
V
K
K
K
G
K
V
I
T
N
N
W
A
G
S
H
H
H
H
---
7
Fugue
70.19
9%
-145
- C2 -
1PW4
-
GLPT_ECOLI
A:
[5-451]
------------------------------------------------------------------------------
F
K
P
A
-----
P
H
K
A
R
L
P
A
A
E
-
I
D
P
T
Y
R
R
L
R
W
Q
I
F
L
G
I
F
F
-----------
G
Y
A
A
Y
Y
L
V
R
K
N
F
A
L
A
M
P
Y
L
V
-
E
-
Q
G
--
F
S
R
G
D
L
G
---
F
A
---------
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
-----
D
--
R
S
--------------------------
N
P
R
V
F
L
P
------
A
G
L
I
L
---
A
-------
A
A
V
M
-
L
-
F
M
G
F
-----
V
P
-
W
A
-----------------------------
T
S
S
I
A
-
V
M
F
V
L
L
F
-------------
L
C
----
G
W
F
Q
G
M
G
W
P
P
C
G
-
R
T
M
V
H
W
W
-
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
C
A
---
H
N
--------------
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
--------------------------
W
-
F
N
D
W
H
------
A
A
L
Y
-----
M
P
-
A
F
----
C
A
I
L
--
V
-
A
L
--
F
-
A
--
F
A
M
MRDTPQ
S
C
G
L
P
P
I
----
E
-
E
--
Y
-
K
---
N
D
T
A
K
Q
I
--
F
-
M
Q
Y
V
L
-----
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
------------------
V
Y
L
L
R
Y
G
I
L
D
----
W
S
P
T
-
Y
L
-
K
-------
E
-
V
KHFA
L
---
D
K
---
S
---
S
W
A
Y
F
L
Y
E
Y
A
G
I
--
P
G
T
L
L
C
G
W
M
S
D
K
V
F
R
G
-----
N
--
R
G
A
T
G
-
V
F
F
M
T
L
V
T
I
A
T
I
-
V
Y
W
M
N
P
A
G
---
N
P
T
V
---
D
M
--
I
C
M
I
V
I
G
F
L
I
---
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
---
P
K
K
--------
A
A
G
T
A
A
G
F
T
----
G
L
F
G
Y
L
G
G
-
S
-
V
-----
A
A
S
A
I
----------------
V
----
G
Y
T
V
-
D
-
F
F
-
G
---
W
--
D
G
G
F
M
-------
V
M
I
G
----
G
S
I
L
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
---
6
Fugue
69.23
11%
-126
- C2 -
1PV6
-
LACY_ECOLI
A:
[1-417]
--------------------------------------------------------------------------------------------------
M
Y
Y
L
K
N
T
N
F
W
M
F
G
L
F
F
F
F
-----------
Y
F
F
I
M
G
A
Y
---
F
P
F
F
P
I
W
L
H
-
D
-
I
N
H-
I
S
K
S
D
T
G
---
I
I
---------
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
-----
D
--
K
L
--------------------------
G
L
R
K
Y
L
L
------
W
I
I
T
G
---
M
-------
L
V
M
F
-
A
-
P
F
F
I
F
I
F
G
P
L
L
-
Q
Y
-----------------------------
N
I
L
V
G
S
I
V
G
G
I
Y
L
-------------
G
F
----
C
F
N
A
G
A
P
A
V
E
A
F
-
I
E
K
V
S
R
R
-
S
N
F
E
F
G
R
A
R
M
F
G
-
C
V
G
---
W
A
--------------
L
G
A
S
I
V
G
I
M
F
T
I
N
N
Q
--------------------------
F
-
V
F
W
L
G
------
S
G
C
A
-----
L
I
-
L
A
----
V
L
L
F
--
F
-
A
K
--
T
-
D
--
A
P
S
------
S
A
T
V
A
N
A
----
V
-
G
--
A
-
N
---
H
S
A
F
S
L
K
--
L
-
A
L
E
L
F
-----
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
------------------
V
S
C
T
Y
D
V
F
D
Q
----
Q
F
A
N
-
F
F
-
T
-------
S
-
F
----
F
---
A
T
---
G
---
E
Q
G
T
R
V
F
G
Y
V
T
T
--
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
-----
I
--
N
R
I
G
--
G
K
N
A
L
L
L
A
G
T
I
M
-
S
V
R
I
I
G
S
S
F
A
T
S
A
L
E
---
V
V
--
I
L
K
T
L
H
M
F
E
V
---
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
V
R
--------
F
S
A
T
I
Y
L
V
C
----
F
C
F
F
K
Q
L
A
M
I
-
F
-----
M
S
V
L
A
----------------
G
----
N
M
Y
E
-
S
-
I
G
-
F
Q
G
A
Y
--
L
V
L
G
L
-------
V
A
L
G
----
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
------
17
HHSearch
69.19
16%
-131
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[36-421]
------------------------------------------------------------------------------------------------------------------
F
L
-----------
W
A
V
A
N
N
L
N
---
D
I
L
L
P
Q
F
Q
Q
-
A
-
F
T
--
L
T
N
F
Q
A
G
---
L
I
---------
Q
S
A
F
Y
F
G
Y
F
I
I
P
I
P
A
G
I
L
M
-----
K
--
K
L
--------------------------
S
Y
K
A
G
I
I
------
T
G
L
F
L
---
Y
-------
A
L
G
A
A
L
-
F
W
P
A
A
E
I
--
M
N
-
Y
T
-----------------------------
L
F
L
V
G
L
F
I
I
A
A
G
L
-------------
G
C
----
L
E
T
A
A
N
P
F
V
T
V
L
-------
G
-
P
E
S
S
G
H
F
R
L
N
L
A
-
Q
T
F
---
N
S
--------------
F
G
A
I
I
A
V
V
F
G
Q
S
L
I
L
SNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
-
L
S
V
Q
T
--------
P
Y
-----
M
I
I
V
A
----
I
V
L
L
--
V
-
A
L
--
L
I
M
L
T
K
F
P
------
A
L
Q
S
D
N
-----
H
-
S
--
D
-
A
---
K
Q
G
S
F
S
A
--
S
-
L
S
R
L
A
-----
R
I
R
H
W
R
W
A
V
L
A
Q
F
C
------------------
Y
-
V
G
A
Q
T
A
C
W
----
S
Y
L
I
-
R
Y
A
V
E
------
E
I
P
----
G
MT
A
G
F
---
A
---
A
N
Y
L
T
G
T
M
V
C
F
F
--
I
G
R
F
T
G
T
W
L
I
S
-
R
F
A
P
-----
H
--
K
--
V
L
-
A
A
Y
A
L
I
A
M
A
L
C
L
-
I
S
A
F
A
G
-----
G
H
V
G
----
L
--
I
A
L
T
L
C
S
A
F
M
---
S
I
Q
Y
P
T
I
F
S
L
G
I
K
N
L
---
G
Q
D
--------
T
K
-
Y
G
S
S
F
I
-----
V
M
T
I
I
G
G
-
G
-
I
-----
V
T
P
V
M
----------------
G
----
F
V
S
D
-
A
-
A
G
N
I
P
T
A
E
--
L
I
P
A
L
-------
C
F
A
V
----
I
F
I
F
A
R
F
R
S
Q
T
---------------------
19
HHSearch
68.10
12%
-141
- C2 -
2CFQ
-
LACY_ECOLI
A:
[4-398]
-------------------------------------------------------------------------------------------------
L
K
N
T
N
F
W
M
F
----
G
L
F
F
F
F
-----------
Y
F
F
I
M
G
A
Y
---
F
P
F
F
P
I
W
L
H
-
D
I
N
H
--
I
S
K
S
D
T
G
---
I
I
---------
F
A
A
I
S
L
F
S
L
L
F
Q
P
L
F
G
L
L
S
-----
D
--
K
L
--------------------------
G
L
R
K
Y
L
L
------
W
I
I
T
G
M
L
V
M
-------
F
A
P
F
F
I
-
F
I
F
G
-----
P
L
L
Q
Y
-----------------------------
N
I
L
V
G
S
I
V
G
G
I
Y
L
-------------
G
F
CFNA
G
A
P
A
V
E
A
F
I
E
K
V
-------
S
-
R
--
R
S
N
F
E
F
G
R
A
-
R
M
F
---
G
C
--------------
V
G
W
A
L
G
A
S
I
V
G
I
M
F
T
--------------------------
I
--
N
N
Q
F
--------
V
F
-----
W
L
-
G
S
----
G
C
A
L
IL
A
-
V
L
--
L
-
F
--
F
A
K
------
T
D
A
P
S
S
A
----
T
V
A
--
N
A
V
GAN
H
S
A
F
S
L
K
--
L
-
A
L
E
L
F
-----
R
Q
P
K
L
W
F
L
S
L
Y
V
I
G
------------------
V
S
C
-
T
Y
D
V
F
D
Q
Q
F
A
N
F
F
T
S
F
F
-
A
-------
T
-
G
E
Q
G
-
T
---
R
V
---
F
---
G
Y
V
T
T
M
G
E
L
L
N
A
--
S
I
M
F
F
A
P
L
I
I
N
-
R
I
G
G
-----
K
--
N
--
A
L
-
L
L
A
G
T
I
M
S
V
R
I
I
-
G
S
S
F
A
T
-----
S
A
L
E
---
V
V
--
I
L
K
T
L
H
M
F
E
V
---
P
F
L
L
V
G
C
F
K
Y
I
T
S
Q
F
---
E
V
R
--------
F
S
A
T
I
Y
L
V
C
F---
C
F
F
K
Q
L
A
M
-
I
-
F
-----
M
S
V
L
A
----------------
G
----
N
M
Y
E
-
S
-
I
G
-
F
Q
G
A
Y
--
L
V
L
G
L
-------
V
A
L
G
----
F
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
------
13
Fugue
66.60
10%
-126
- C2 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
--------------------------------------------------------------------------------------------
L
L
L
M
L
V
L
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
-----------
D
M
A
R
D
L
N
V
---
R
-----------------
E
G
A
V
Q
---
S
V
---------
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
-----
D
--
R
V
--------------------------
G
R
R
P
V
I
L
------
V
G
M
S
I
---
F
-------
M
L
A
T
-
L
V
A
V
T
T
-----
S
S
-
L
T
-----------------------------
V
L
I
A
A
S
A
M
Q
G
M
G
T
-------------
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
-
Y
E
R
T
Q
L
-------
R
H
A
N
S
L
L
-
N
M
G
---
I
L
--------------
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
-
W
N
W
R
A
------
C
Y
L
F
-----
L
L
-
V
L
----
C
A
G
V
--
T
-
F
S
--
M
-
A
--
R
W
M
------
P
E
T
R
P
V
D
----
A
-
P
--
R
-------
T
R
L
L
T
--
S
-
Y
K
T
L
F
-----
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
------------------
G
L
A
G
I
A
A
F
E
A
----
C
S
G
V
-
L
M
-
G
-------
A
-
V
----
L
---
G
L
---
S
---
S
M
T
V
S
I
L
F
I
L
P
I
--
P
A
A
F
F
G
A
W
F
A
G
R
---------------
P
N
-
K
R
F
S
T
L
M
W
Q
S
V
I
-
C
C
L
L
A
G
L
L
M
W
I
P
D
W
F
---
G
V
--
M
N
V
W
T
L
L
V
P
A
---
A
L
F
F
F
G
A
G
M
L
F
-------
P
L
A
--------
T
S
G
A
M
E
P
F
P
----
F
L
A
G
T
A
G
A
-
L
-
V
-----
G
G
L
Q
N
----------------
I
----
G
S
G
V
-
L
-
A
S
-
L
S
A
M
L
--
P
Q
T
G
Q
-------
G
S
L
G
----
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
---------------
11
Fugue
65.28
17%
-127
- C2 -
4Z24
1
YR135_MIMIV
A:
[4-652]
NLTGD
I
V
I
I
G
AG
A
A
G
S
L
L
A
H
Y
L
A
R
F
S
N
M
K
I
I
L
L
E
AGHSHFND
P
V
V
T
D
P
-----------
M
G
F
F
G
K
Y
NPP
N
--
E
N
I
S
--
M
S
Q
N
PSYSW
Q
G
A
Q
E
P
N
T
G
A
Y
G
N
R
P
I
I
A
H
G
M
G
F
G
G
S
T
M
I
NRLNLVVGG
R
T
V
F
D
N
D
W
------
P
V
G
W
K
Y
D
D
-
V
-
K
N
--
Y
F
R
R
V
L
V
---
D
I
NPVRDNTKA
S
I
T
S
V
A
L
D
A
L
R
I
I
A
E
Q
Q
I
A
S
GEPV
D
--
F
L
LNKATGNVPNVEKTTPD
A
V
P
L
N
LNDY
E
G
V
N
S
V
V
------
A
F
S
S
F
---
Y
M
G
V
N
Q
L
S
D
G
N
Y
-
I
-
R
K
Y
A
-----
G
N
-
T
Y
LNRNYVDENGRGIGKFSG
L
R
V
V
S
D
A
V
V
D
R
I
I
F
K
G
N
R
A
V
G
V
N
Y
I
D
REG
I
M
H
Y
V
K
V
N
K
E
----
V
V
V
T
S
G
A
F
Y
T
P
T
-
I
L
Q
R
S
G
I
G
D
F
T
Y
L
S
S
I
G
V
K
N
-
L
V
Y
---
N
N
PLVGTG
L
K
N
H
Y
S
P
V
T
I
T
R
V
H
G
E
P
S
E
V
S
R
F
--------------------------
L
-
S
N
M
A
A
------
N
P
T
N
MGFKG
L
A
-
E
L
----
G
F
H
R
--
L
-
D
P
--
N
-
K
--
P
A
N
------
A
N
T
V
T
Y
R
----
K
-
Y
--
Q
-
L
---
M
M
T
A
G
V
G
IP
A
-
E
Q
Q
Y
L
S
GLSP
S
S
N
N
L
F
T
L
I
A
D
D
I
R
------------------
F
A
P
E
G
Y
I
K
I
------
G
T
P
-
N
I
---------
P
-
R
----
D
---
V
P
-------
K
I
F
F
N
T
F
V
T
Y
T
P
--
T
S
A
P
A
D
Q
Q
W
P
I
A
Q
K
T
L
-----
A
--
P
L
I
S
A
-
L
L
G
Y
D
I
I
Y
Q
T
L
M
S
M
N
Q
T
A
R
D
S
G
F
Q
V
S
L
E
---
M
V
YP
L
N
D
L
I
Y
K
L
H
N
---
G
L
A
T
Y
G
A
N
W
W
H
Y
F
V
P
---
T
L
V
GDDT
P
A
G
R
E
F
A
D
T
L
S
K
L
S
Y
Y
P
R
V
G
A
H
L
D
S
-
H
-
Q
-----
G
C
S
C
S
----------------
I
GRTV
D
S
N
L
-
K
V
I
G
-
T
Q
N
V
R
V
A
D
L
S
A
A
AFPPGGN
T
W
A
T
----
A
S
M
I
G
A
R
A
V
D
L
I
L
G
F
P
Y
L
R
D
L
P
V
N
D
V
P
I
L
N
V
N
12
Fugue
64.62
13%
-147
- C2 -
3EWE
-
NUP85_YEAST
B:
[65-555]
------------------------------------------
M
P
L
K
F
K
-----------
L
G
P
L
S
Y
Q
---
N
--
M
A
F
I
--
T
K
Y
K
-----
L
Y
P
V
R
I
P
R
L
D
T
S
K
E
---------
F
S
A
Y
V
S
-----------
G
L
F
E
I
Y
R
D
---
L
G
D
K
E
H
N
A
T
-
V
-
N
L
--
A
M
E
A
I
L
N
---
E
L
---------
E
V
F
I
G
R
V
K
--------------------------------------------------
D
V
N
R
------
F
Y
E
L
E
---
E
-------
S
L
T
V
-
L
-
N
C
L
R
-----
T
M
-
Y
F
-----------------------------
I
L
---------
N
R
-------------
S
E
----
F
I
E
S
L
L
N
W
I
N
R
S
-
D
G
E
-----
P
D
E
E
Y
I
E
Q
V
E
T
Q
-
Y
F
W
---
K
L
--------------
L
N
Q
L
V
L
R
G
L
L
S
Q
A
I
G
--------------------------
C
-
I
E
R
S
D
------
L
L
C
A
-----
V
S
-
F
D
----
A
V
S
D
--
S
-
I
E
--
L
-
L
--
T
F
R
------
E
W
K
N
L
V
L
----
K
-
L
--
S
-
Q
---
A
F
S
---
G
--
E
-
L
R
D
Y
I
-----
E
D
F
L
L
V
I
G
G
N
Q
R
K
I
L
Q
Y
SRT------------
W
Y
E
S
F
C
G
F
L
L
----
Y
Y
I
P
-
S
L
-
E
-------
L
-
S
----
A
---
E
Y
---
L
---
Q
M
S
L
E
A
N
V
V
D
I
T
ND
W
E
Q
P
C
V
D
I
I
S
G
K
I
-----------
H
S
I
L
P
-
V
M
E
S
L
D
S
C
T
A
A
F
-
T
A
M
I
C
E
A
K
G
L
F
S
Y
R
N
---
G
M
--
A
S
Y
M
L
N
S
F
A
F
---
E
L
C
S
L
G
D
K
E
L
--------------------
W
P
V
A
I
G
L
I
----
A
T
R
S
A
K
K
M
-
V
-
I
-----
A
E
L
L
P
----------------
H
----
Y
P
F
V
-------------
T
N
D
D
I
-------
E
W
M
L
----
S
I
C
V
E
W
R
L
P
E
I
A
K
E
I
Y
T
T
L
G
N
Q
M
L
S
A
H
N
I
I
E
S
16
HHSearch
63.28
8%
-145
- C2 -
1PW4
-
GLPT_ECOLI
A:
[49-434]
------------------------------------------------------------------------------------------------------------------------------------------
A
L
A
M
P
Y
-
L
V
-
E
-
Q
G
--
F
S
R
G
D
L
G
---
F
A
---------
L
S
G
I
S
I
A
Y
G
F
S
K
F
I
M
G
S
V
S
-----
D
--
R
S
--------------------------
N
P
R
V
F
L
P
------
A
G
L
I
L
---
A
-------
A
A
V
M
L
F
-
M
G
F
V
P
W
A
T
-
S
S
-
I
A
-----------------------------
V
M
F
V
L
L
F
L
C
G
W
F
Q
-------------
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
-------
W
-
S
Q
K
E
R
G
G
I
V
S
V
W
-
N
C
A
---
H
N
--------------
V
G
G
G
I
P
P
L
L
F
L
L
G
M
A
--------------------------
W
F
N
D
W
H
A
--------
A
L
-----
Y
M
-
P
A
F
---
C
A
I
L
V
A
L
-
F
A
--
F
-
A
--
M
M
R
------
D
T
P
Q
S
C
G
LPPI
E
-
E
YK
N
-
D
------
T
A
K
Q
--
I
F
M
Q
Y
V
L
-----
P
N
K
L
L
W
Y
I
A
I
A
N
V
F
------------------
V
Y
L
-
L
R
Y
G
I
L
----
D
W
S
P
-
T
Y
L
K
-------
E
V
K
----
H
FA
L
D
K
---
S
---
S
W
A
Y
F
L
Y
E
Y
A
G
I
--
P
G
T
L
L
C
G
W
M
S
D
-
K
V
F
R
-----
G
--
N
R
G
A
T
G
V
F
F
M
T
L
V
T
I
A
T
I
-
V
Y
W
M
N
P
A
---
G
N
P
T
V
---
D
M
--
I
C
M
I
V
I
G
F
L
I
---
Y
G
P
V
M
L
I
G
L
H
A
L
E
L
A
---
P
K
K
--------
A
A
G
T
A
A
G
F
T
----
G
L
F
G
Y
L
G
G
-
S
V
A
-----
A
S
A
I
V
----------------
G
----
Y
T
V
D
-
F
-
F
G
-
W
D
G
G
F
--
M
V
M
I
G
-------
G
S
I
L
----
A
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
-------
18
HHSearch
61.80
11%
-110
- C2 -
2GFP
-
EMRD_ECOLI
A:
[17-360]
-----------------------------------------------------------------------------------------------------------------
V
A
V
-----------
G
Q
M
A
Q
T
I
Y
---
I
P
A
I
A
D
M
A
R
-
D
-
L
N
--
V
R
E
G
A
V
Q
---
S
V
---------
M
G
A
Y
L
L
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
-----
D
--
R
V
--------------------------
G
R
R
P
V
I
L
------
V
G
M
S
I
---
F
-------
M
L
A
T
L
V
-
A
V
T
T
-----
S
S
-
L
T
-----------------------------
V
L
I
A
A
S
A
M
Q
G
M
G
T
-------------
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
-------
Y
-
E
R
T
Q
L
R
H
A
N
S
L
L
-
N
M
G
---
I
L
--------------
V
S
P
L
L
A
P
L
I
G
G
L
L
D
T
--------------------------
M
-
W
N
W
R
A
--------
C
Y
-----
L
F
-
L
L
----
V
L
C
A
--
G
V
T
F
SM
A
-
R
--
W
M
P
------
E
T
R
P
V
D
A
----
P
-----------
R
T
R
L
L
T
--
S
-
Y
K
T
L
F
-----
G
N
S
G
F
N
C
Y
L
L
M
L
I
G
------------------
G
-
L
A
G
I
A
A
F
E
----
A
C
S
G
-
V
L
M
G
A
------
V
-
L
----
G
L
S
S
M
T
---
V
---
S
I
L
F
I
L
P
I
P
A
A
F
--
F
G
A
W
F
A
G
R
P
N
K
-
R
F
S
T
-----
L
--
M
W
-
Q
S
-
V
I
C
C
L
L
A
G
L
L
-
M
-
W
I
P
D
W
F
--
G
V
M
N
V
W
T
---
L
L
--
V
P
A
A
L
F
F
F
G
A
---
G
M
L
F
P
L
A
T
S
G
A
M
E
P
F
---
P
-
F
--------
L
A
G
T
A
G
A
L
V
----
G
G
L
Q
N
I
G
S
-
G
-
V
-----
L
A
S
L
S
----------------
A
----
M
L
P
Q
-
T
-
G
Q
-
G
S
L
G
L
--
L
M
T
L
M
-------
G
L
L
I
----
V
L
C
W
L
P
L
-------------------------
22
HHSearch
47.23
11%
-115
- C2 -
1PW4
-
GLPT_ECOLI
A:
[63-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
---
L
---
G
F
A
L
S
G
I
S
I
A
Y
G
--
F
S
K
F
I
M
G
S
V
S
D
-
R
S
N
P
-----
R
--
V
--
F
L
-
P
A
G
L
I
L
A
A
A
V
M
L
-
F
M
G
F
V
P
W
A
-
T
S
S
I
A
V
---
M
F
--
V
L
L
F
L
C
G
W
F
Q
---
G
M
G
W
P
P
C
G
R
T
M
V
H
W
W
---
S
Q
K
--------
E
R
G
G
I
V
S
V
W
----
N
C
A
H
N
V
G
G
-
G
-
I
-----
P
P
L
L
F
----------------
L
----
L
G
M
A
W
F
-
N
D
-
W
H
A
A
L
--
Y
M
P
A
F
-------
C
A
I
L
----
V
A
L
F
A
F
A
M
M
R
D
T
P
Q
S
C
G
L
P
P
I
E
E
Y
K
N
D
T
A
K
Q
I
20
HHSearch
44.71
11%
-132
- C2 -
3WDO
-
?
A:
[46-180]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
---
I
---
G
I
A
I
G
I
Y
G
L
T
Q
A
--
V
F
Q
I
P
F
G
L
L
S
D
-
R
I
G
R
-----
K
--
P
--
L
I
-
V
G
G
L
A
V
F
A
A
G
S
V
-
I
A
A
L
S
D
-----
S
I
W
G
---
I
I
--
L
G
R
A
L
Q
G
S
G
A
-----
I
A
A
A
V
M
A
L
L
S
D
L
T
---
R
E
Q
--------
N
R
T
K
A
M
A
F
I
----
G
V
S
F
G
I
T
F
-
A
-
I
-----
A
M
V
L
G
----------------
P
----
I
I
T
H
-
K
-
L
G
-
L
H
A
L
F
--
W
M
I
A
I
-------
L
A
T
T
----
G
I
A
L
T
I
W
V
V
P
N
S
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
F
S
K
V
L
21
HHSearch
41.47
10%
-102
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[45-177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
----
I
L
L
P
-
Q
F
Q
Q
-------
A
-
F
----
T
LTN
F
Q
---
A
---
G
L
I
Q
S
A
F
Y
F
G
Y
F
--
I
I
P
I
P
A
G
I
L
M
K
-
K
L
S
Y
-----
K
--
A
--
G
I
-
I
T
G
L
F
L
Y
A
L
G
A
A
-
L
F
W
P
A
A
E
--
I
M
N
Y
T
L
---
F
L
--
V
G
L
F
I
I
A
A
G
L
---
G
C
L
E
T
A
A
N
P
F
V
T
V
L
G
---
P
E
S
--------
S
G
H
F
R
L
N
L
A
----
Q
T
F
N
S
F
G
A
-
I
-
I
-----
A
V
V
F
G
----------------
Q
----
S
L
I
L
-
S
-
N
V
-
P
H
Q
S
Q
--
D
V
L
D
K
-------
M
S
P
E
----
Q
L
S
A
Y
K
H
S
L
V
L
S
V
Q
T
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
I
M
24
HHSearch
41.34
12%
-90
- C2 -
2CFQ
-
LACY_ECOLI
A:
[255-380]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
Q
G
T
R
V
F
G
---
Y
V
---------
T
T
M
G
E
L
L
N
A
S
I
M
F
F
A
P
L
I
I
-----
N
--
R
I
--------------------------
G
G
K
N
A
L
L
------
L
A
G
T
I
---
M
-------
S
V
R
I
I
G
-
S
S
F
A
-----
T
S
-
A
L
-----------------------------
E
V
V
I
L
K
T
L
H
M
F
E
V
-------------
P
F
----
L
L
V
G
C
F
K
Y
I
T
S
Q
-------
F
-
E
V
R
F
S
A
T
I
Y
L
V
C
F
C
F
F
---
K
Q
--------------
L
A
M
I
F
M
S
V
L
A
G
N
M
Y
E
--------------------------
S
-
I
G
F
Q
G
------
A
Y
L
V
-----
L
G
-
L
V
----
A
L
G
F
--
T
-
L
I
--
S
-
V
--
F
T
L
------
S
G
P
G
P
L
S
----
L
-
L
--
R
-
R
---
Q
V
N
E
V
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
39.51
11%
-88
- C2 -
2GFP
-
EMRD_ECOLI
A:
[43-174]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
---
V
---
Q
S
V
M
G
A
Y
L
L
T
Y
G
--
V
S
Q
L
F
Y
G
P
I
S
D
-
R
V
G
R
-----
R
--
P
--
V
I
-
L
V
G
M
S
I
F
M
L
A
T
L
-
V
A
V
T
T
S
-----
S
L
T
V
---
L
I
--
A
A
S
A
M
Q
G
M
G
T
---
G
V
G
G
V
M
A
R
T
L
P
R
D
L
Y
---
E
R
T
--------
Q
L
R
H
A
N
S
L
L
----
N
M
G
I
L
V
S
P
-
L
-
L
-----
A
P
L
I
G
----------------
G
----
L
L
D
T
-
M
-
W
N
-
W
R
A
C
Y
--
L
F
L
L
V
-------
L
C
A
G
----
V
T
F
S
M
A
R
W
M
P
E
T
R
P
V
D
A
P
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
2
PsiBlast_PDB
37.16
34%
-88
- C3 -
4J1O
1
HPBD_PARDP
A:
[23-91]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
E
I
H
V
Y
A
H
D
L
-
P
V
K
D
G
P
Y
T
I
A
S
S
-
T
V
W
---
S
L
--------------
Q
T
T
L
V
K
I
V
A
D
S
G
L
A
G
--------------------------
W
-
G
E
T
C
P
------
V
G
P
T
-----
Y
A
-
P
S
----
H
A
L
G
--
A
-
R
A
--
A
-
L
--
A
E
M
------
A
P
G
L
I
G
A
----
N
-
P
--
L
-
Q
---
P
L
V
L
R
R
R
--
M
-
D
G
L
L
C
-----
G
H
N
Y
A
K
A
A
I
D
I
A
A
Y
------------------
D
L
M
G
K
H
Y
G
V
R
----
V
A
D
L
-
L
G
-
G
-------
V
-
A
----
A
---
E
R
---
V
---
P
S
Y
Y
A
T
G
I
G
Q
P
D
--
E
I
A
R
I
A
A
E
K
V
A
E
G
F
P
R
-----
L
--
Q
I
K
I
G
-
G
R
P
V
E
I
D
I
E
T
V
R
-
K
V
W
E
R
I
R
G
T
G
T
R
L
A
V
---
D
G
--
N
R
S
L
P
S
R
D
A
L
---
R
L
S
R
E
C
P
E
I
P
F
V
L
E
Q
---
P
C
N
--------
T
L
E
E
I
A
A
I
R
----
G
R
V
Q
H
G
I
Y
-
L
-
D
-----
E
S
G
E
D
----------------
L
----
S
T
V
I
-
R
-
A
A
-
G
Q
G
L
C
--
D
G
F
G
M
-------
K
L
T
R
----
I
G
G
L
Q
Q
M
A
A
F
R
D
I
C
E
A
R
A
L
P
H
S
C
D
D
A
W
G
G
D
I
I
1
PsiBlast_PDB
35.09
34%
-89
- C3 -
4IZG
1
HPBD_PARDP
A:
[23-91]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
E
I
H
V
Y
A
H
D
L
-
P
V
K
D
G
P
Y
T
I
A
S
S
-
T
V
W
---
S
L
--------------
Q
T
T
L
V
K
I
V
A
D
S
G
L
A
G
--------------------------
W
-
G
E
T
C
P
------
V
G
P
T
-----
Y
A
-
P
S
----
H
A
L
G
--
A
-
R
A
--
A
-
L
--
A
E
M
------
A
P
G
L
I
G
A
----
N
-
P
--
L
-
Q
---
P
L
V
L
R
R
R
--
M
-
D
G
L
L
C
-----
G
H
N
Y
A
K
A
A
I
D
I
A
A
Y
------------------
D
L
M
G
K
H
Y
G
V
R
----
V
A
D
L
-
L
G
-
G
-------
V
-
A
----
A
---
E
R
---
V
---
P
S
Y
Y
A
T
G
I
G
Q
P
D
--
E
I
A
R
I
A
A
E
K
V
A
E
G
F
P
R
-----
L
--
Q
I
K
I
G
-
G
R
P
V
E
I
D
I
E
T
V
R
-
K
V
W
E
R
I
R
G
T
G
T
R
L
A
V
---
D
G
--
N
R
S
L
P
S
R
D
A
L
---
R
L
S
R
E
C
P
E
I
P
F
V
L
E
Q
---
P
C
N
--------
T
L
E
E
I
A
A
I
R
----
G
R
V
Q
H
G
I
Y
-
L
-
D
-----
E
S
G
E
D
----------------
L
----
S
T
V
I
-
R
-
A
A
-
G
Q
G
L
C
--
D
G
F
G
M
-------
K
L
T
R
----
I
G
G
L
Q
Q
M
A
A
F
R
D
I
C
E
A
R
A
L
P
H
S
C
D
D
A
W
G
G
D
I
I