@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S22AB_HUMAN: (2015-12-09 )
MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL
Atome Classification :
(20 SA)
-------------------.........10.----.......20----........30........40........50........----60.....---...70........80.-----------.......90........100.......110......--.120.......130........140.......150.--------........160.......170--....----.---...180-....------------...------------------.---------------------.190-.---------.------------------...--....200...--....----210.......220---.....-..--230.......240----------.------------......250.----.-----------------------------.-----------...-..260.......270-..--.....280--------....----....290.......300...--.-...310......--------------.320.......330-..--......340---.----......350.----......360....----..-.------370-----.---..------.--....380-----.-----.....-..--------390..-..--...400..--.-.---...--410-..-..--.....420....---------..---.430.......440...--.-...--------450-----------...-------------.---...460......--------.470.....-..----480..-..-.-..490..--------.--------....500..-.....510.......520.......530.......540.......550
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------M
A
F
S
K
L
L
E
QAGG----
V
G
L
F
Q
T
L
Q
V
----
L
T
F
I
L
P
C
L
MI
P
S
Q
M
L
L
E
N
F
S
AAIPG
H
R
C
W
T
H
MLDNGSA----VSTNMTP---
K
A
L
L
T
I
SIPPGPNQG
P
-----------
H
Q
C
R
RFRQPQ
W
Q
L
LDPNATATSWSEADTEPCVD
G
W
V
--YD
R
S
V
F
T
S
T
I
V
A
K
-
W
D
L
V
CSSQGL
K
P
L
S
Q
S
I
F
M
--
S
--------
G
I
L
V
G
S
F
I
W
G
L
L
S
Y
RFGR
K
P
---
M
L
S
W
----
C
---
C
L
Q
L
---
A
VAG------------TST------------------I---------------------F
A
---
P
---------
T
------------------
F
V
I
--
Y
C
G
L
R
F
V
A
A
F
--
G
M
A
G
----
I
F
L
S
S
L
T
L
M
V
E
W
T---TTS
R
R
-
A
V
--
T
M
T
V
V
G
CA
F
S
A
G
Q
----------
A
------------
A
L
G
G
L
A
F
A
-
L
----R-----------------------------D-----------
W
R
T
-
L
Q
L
AASV
P
F
F
A
I
S
L
I
-
S
W
--WLPESA
R
---------
W
L
I
I
----KGK
P
D
Q
A
L
Q
E
L
R
K
V
A
R
INGH--K-EAKN
L
T
I
E
V
L
M
S
--------------
S
V
K
E
E
V
A
SAK
E
P
R
--
S
V
--
L
D
L
F
C
V
P
V
L
---
R
----
W
R
S
C
A
M
L
V
V
N
----
F
S
L
L
I
S
Y
Y
G
L
V
F
D
----
L
Q
-
S
------L-G-----
R
---
D
I
------
F
--
L
L
Q
A
L
-
F
-----
G
-----
A
V
D
F
L
-
G
R
--------
A
T
T
A
L
-
L
L
--
S
F
L
G
R
R
T
I
--
Q
-
A
---
G
S
Q
--
A
---
M
A
-
G
L
--
A
I
L
A
N
MLVP
Q
D
L
---------
Q
T
---
L
R
V
V
F
A
V
LGKGCF
G
I
S
L
--
T
-
C
L
T
--------
I
Y
K-----------AEL-------------F---PTP
V
R
M
T
A
D
G
I
L
--------
H
T
V
G
R
L
G
A
M
-
M
G
----
P
L
I
L
M-SR-Q-ALPLL
P
P
--------
L
--------
L
Y
G
V
I
S
I
A
S
-
S
L
V
V
L
F
F
LPETQGLPL
P
D
T
I
Q
D
L
E
S
Q
K
S
TAAQGNR
Q
E
A
V
T
VESTSL
21
Fugue
86.67
18%
-109
- C2 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
---------------------------------------
Y
N
S
S
Y
----
I
F
S
I
T
L
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
----------------------------------------------------------------
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
G
F
C
--
V
A
----------------------------
S
A
L
--
I
--------
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
---
S
L
K
I
----
A
---
A
V
L
F
---
F
I
S
G
------------
V
G
S
A
WPELGFTSINPDNTVPV
Y
---------------------
L
A
---
G
---------
Y
------------------
V
P
E
--
F
V
I
Y
R
I
I
G
G
I
--
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
---
P
A
H
I
R
-
G
K
--
L
V
S
F
N
Q
F
A
I
I
F
G
Q
----------
L
------------
L
V
Y
C
V
N
Y
F
-
I
----
A
-----------------------------
R
S
GD
A
S
W
L
N
T
D
G
W
R
Y
-
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
Y
--
T
V
P
E
S
P
R
---------
W
L
M
S
----
R
G
K
Q
E
Q
A
E
G
I
L
R
K
I
M
---
G
N
--
T
-
L
A
T
Q
A
V
Q
E
I
K
H
S
--------------
L
D
H
G
R
K
T
G
G
R
L
L
M
--
F
----
G
V
G
V
I
V
I
G
---
V
----
M
L
S
I
F
Q
Q
F
V
G
----
I
N
V
V
L
Y
Y
A
P
E
V
F
K
----
T
L
-
G
------
A
-
S
-----
T
---
D
I
------
A
--
L
L
Q
T
I
-
I
-----
V
-----
G
V
I
N
L
-
T
F
--------
T
V
L
A
I
M
T
V
--
D
K
F
G
R
K
P
L
Q
I
I
-
G
---
A
L
G
--
M
---
A
I
-
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
---------
G
I
---
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
--
G
-
P
V
C
W
-------
V
L
L
-----------
S
E
I
-------------
F
---
P
N
A
I
R
G
K
A
L
A
I
A
--------
V
A
A
Q
W
L
A
N
Y
-
F
V
S
W
T
F
P
M
M
D
K
-
N
S
-
W
-
L
V
A
H
F
H
N
G
F
S
Y
----
W
--------
I
Y
G
C
M
G
V
L
A
-
A
L
F
M
W
K
F
V
P
E
T
K
G
----
K
T
L
E
E
L
E
A
L
W
E
------------------
2
PsiBlast_PDB
85.87
21%
-96
- C2 -
4GBZ
5
XYLE_ECOLI
A:
[26-479]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
A
V
I
S
G
T
V
E
S
L
-
N
T
V
F
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
--
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
---
S
L
K
I
----
A
---
A
V
L
F
---
F
I
S
G
------------
V
G
S
------------------
A
W
PELGFTSINPDNTVPVYLAG
Y
V
---
P
---------
E
------------------
F
V
I
--
Y
---
R
I
I
G
G
I
--
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
---
P
A
H
I
R
-
G
K
--
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
------------
R
S
G
D
A
S
W
L
-
N
----
T
-----------------------------
D
G
----------
W
R
Y
-
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
Y
--
T
V
P
E
S
P
R
---------
W
L
M
S
----
R
G
K
Q
E
Q
A
E
G
I
L
R
K
---
I
M
G
N
--
T
-
L
A
T
Q
A
V
Q
E
-------------------
I
K
H
S
L
D
H
G
R
K
T
G
--
G
R
--
L
L
M
F
G
V
G
V
I
V
I
G
V
----
M
L
S
I
F
Q
Q
F
V
G
----
I
N
V
V
L
Y
Y
A
P
E
V
F
K
----
T
L
-
G
------
A
-
S
-----
T
---
D
I
------
A
--
L
L
Q
T
I
-
I
V
----
G
-----
V
I
N
L
T
-
F
T
--------
V
L
A
I
M
-
T
V
--
D
K
F
G
R
K
P
L
--
Q
I
I
---
G
A
L
--
G
---
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
---------
G
I
---
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
GP
V
-
C
W
V
--------
L
L
------------
S
E
I
-------------
F
---
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
-
M
D
----
K
N
S
W
L
-
V
A
-
H
-
F
H
N
G
F
S
Y
--------
W
--------
I
Y
G
C
M
G
V
L
A
-
A
L
F
M
W
K
F
V
P
E
T
K
G
----
K
T
L
E
E
L
E
A
L
W
E
------------------
3
PsiBlast_PDB
85.78
21%
-96
- C2 -
4GC0
5
XYLE_ECOLI
A:
[26-479]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
A
V
I
S
G
T
V
E
S
L
-
N
T
V
F
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
--
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
---
S
L
K
I
----
A
---
A
V
L
F
---
F
I
S
G
------------
V
G
S
------------------
A
WPELGFTSINPDNTVPVYLAG
Y
V
---
P
---------
E
------------------
F
V
I
--
Y
---
R
I
I
G
G
I
--
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
---
P
A
H
I
R
-
G
K
--
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
------------
R
S
G
D
A
S
W
L
-
N
----
T
-----------------------------
D
G
----------
W
R
Y
-
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
Y
--
T
V
P
E
S
P
R
---------
W
L
M
S
----
R
G
K
Q
E
Q
A
E
G
I
L
R
K
---
I
M
G
N
--
T
-
L
A
T
Q
A
V
Q
E
-------------------
I
K
H
S
L
D
H
G
R
K
T
G
--
G
R
--
L
L
M
F
G
V
G
V
I
V
I
G
V
----
M
L
S
I
F
Q
Q
F
V
G
----
I
N
V
V
L
Y
Y
A
P
E
V
F
K
----
T
L
-
G
------
A
-
S
-----
T
---
D
I
------
A
--
L
L
Q
T
I
-
I
V
----
G
-----
V
I
N
L
T
-
F
T
--------
V
L
A
I
M
-
T
V
--
D
K
F
G
R
K
P
L
--
Q
I
I
---
G
A
L
--
G
---
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
---------
G
I
---
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
-
C
W
V
--------
L
L
------------
S
E
I
-------------
F
---
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
-
M
D
----
K
N
S
W
L
-
V
A
-
H
-
F
H
N
G
F
S
Y
--------
W
--------
I
Y
G
C
M
G
V
L
A
-
A
L
F
M
W
K
F
V
P
E
T
K
G
----
K
T
L
E
E
L
E
A
L
W
E
------------------
1
PsiBlast_PDB
85.73
21%
-98
- C2 -
4GBY
5
XYLE_ECOLI
A:
[26-479]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
A
V
I
S
G
T
V
E
S
L
-
N
T
V
F
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
--
G
F
C
V
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
---
S
L
K
I
----
A
---
A
V
L
F
---
F
I
S
G
------------
V
G
S
------------------
A
WPELGFTSINPDNTVPVYLAG
Y
V
---
P
---------
E
------------------
F
V
I
--
Y
---
R
I
I
G
G
I
--
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
---
P
A
H
I
R
-
G
K
--
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
------------
R
S
G
D
A
S
W
L
-
N
----
T
-----------------------------
D
G
----------
W
R
Y
-
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
Y
--
T
V
P
E
S
P
R
---------
W
L
M
S
----
R
G
K
Q
E
Q
A
E
G
I
L
R
K
---
I
M
G
N
--
T
-
L
A
T
Q
A
V
Q
E
-------------------
I
K
H
S
L
D
H
G
R
K
T
G
--
G
R
--
L
L
M
F
G
V
G
V
I
V
I
G
V
----
M
L
S
I
F
Q
Q
F
V
G
----
I
N
V
V
L
Y
Y
A
P
E
V
F
K
----
T
L
-
G
------
A
-
S
-----
T
---
D
I
------
A
--
L
L
Q
T
I
-
I
V
----
G
-----
V
I
N
L
T
-
F
T
--------
V
L
A
I
M
-
T
V
--
D
K
F
G
R
K
P
L
--
Q
I
I
---
G
A
L
--
G
---
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
---------
G
I
---
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
-
C
W
V
--------
L
L
------------
S
E
I
-------------
F
---
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
-
M
D
----
K
N
S
W
L
-
V
A
-
H
-
F
H
N
G
F
S
Y
--------
W
--------
I
Y
G
C
M
G
V
L
A
-
A
L
F
M
W
K
F
V
P
E
T
K
G
----
K
T
L
E
E
L
E
A
L
W
E
------------------
5
PsiBlast_PDB
83.44
23%
-121
- C2 -
4J05
-
?
A:
[86-519]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
V
V
G
Q
V
M
F
G
V
L
G
D
S
F
G
R
K
F
---
V
Y
G
K
----
E
---
L
I
L
I
---
I
V
A
T
------------
I
F
Q
------------------
M
---------------------
S
A
---
P
SHWD
G
N
R
V
L
T
------------------
W
I
T
--
I
C
--
R
V
F
L
G
I
--
G
I
G
G
----
D
Y
P
M
S
A
T
V
V
S
D
R
A
---
N
I
H
R
R
-
G
T
--
L
L
----
C
F
I
F
A
N
Q
----------
G
W
G
S
F
V
G
S
L
V
T
I
V
T
I
S
G
F
K
H
R
-
L
----
K
-----------------------------
S
GHTHD
V
D
K
A
--
W
R
I
-
L
I
G
L
S
L
I
P
A
F
G
T
L
Y
Q
-
R
------------------------------------------------------------------------------------------------
W
Q
E
F
V
A
Y
F
S
---
T
----
W
N
H
F
R
N
L
L
G
S
M
L
G
W
F
L
V
D
I
A
F
Y
G
I
N
L
N
QSVV
L
A
-
Q
------
I
-
G
FAGKT
G
---
D
V
------
Y
D
K
L
F
Q
L
A
-
T
-----
G
N
I
I
V
T
A
L
G
F
L
P
G
Y
--------
Y
F
T
L
F
-
L
I
--
D
I
V
G
R
K
K
L
--
Q
-
F
---
M
G
F
--
I
---
M
S
-
G
L
F
L
A
I
L
A
G
E
I
D
H
I
G
K
---------
G
P
---
L
L
A
C
F
T
F
M
Q
F
F
F
N
F
G
A
N
--
T
-
T
T
F
--------
I
V
A
-----------
A
E
L
-------------
F
---
P
T
R
I
R
A
S
A
H
G
I
S
--------
A
A
A
G
K
C
G
A
I
-
L
S
----
S
L
V
F
N
-
Q
L
-
K
-
A
K
I
G
T
S
A
--------
V
--------
L
W
I
F
F
S
T
C
I
L
G
F
I
S
T
F
L
I
D
E
T
M
G
V
D
-
P
D
E
-
K
D
L
E
E
R
R
A
R
-----------------
6
PsiBlast_PDB
82.81
22%
-104
- C2 -
4ZW9
4
?
A:
[87-492]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
V
A
I
F
S
--
V
--------
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
---
S
M
L
I
----
V
---
N
L
-
L
---
A
V
T
G
G
C
F
M
G
L
CKVAKS
V
E
M
------------------
L
---------------------
I
L
---
G
---------
R
------------------
L
V
I
G
L
F
C
G
L
----
C
T
--
G
F
V
P
----
M
Y
I
G
------
E
I
S
---
P
T
A
L
R
-
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
----------
A
------------
Q
I
F
G
L
E
F
I
-
L
----
G
-----------------------------
S
EEL--------
W
P
L
-
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
--
F
C
P
E
S
P
R
---------
F
L
L
I
----
N
R
K
E
E
E
N
A
K
Q
I
L
Q
--
R
L
W
G
T
--
Q
-
D
V
S
Q
D
I
Q
E
-------------------
M
K
D
E
S
A
R
M
S
Q
E
K
QV
T
V
--
L
E
L
F
R
V
S
S
Y
---
R
----
Q
P
I
I
I
S
I
V
L
Q
----
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
----
Y
S
-
T
G
-----
I
-
F
-----
K
---
D
A
------
G
--
V
Q
E
P
I
-
Y
A
T
I
G
A
G
-----
V
V
N
T
I
-
F
T
--------
V
V
S
L
F
-
L
V
--
E
R
A
G
R
R
T
L
--
H
-
M
I
G
L
G
G
M
--
A
---
F
C
-
S
T
--
L
M
T
V
S
L
L
L
K
D
N
Y
---------
N
G
---
M
S
F
V
-------
C
I
G
A
I
L
--
V
-
F
V
A
--------
F
F
E
IGPG
P
I
P
W
F
I
V
A
E
L
-------------
F
SQG
P
R
P
A
A
M
A
V
A
G
C
S
--------
N
W
T
S
N
F
--
L
-
V
G
----
L
L
F
P
S
-
A
A
-
H
-
Y
L
G
A
Y
V
F
--------
I
--------
I
F
T
G
F
L
I
T
F
-
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
------------------
7
PsiBlast_PDB
81.81
22%
-102
- C2 -
4ZWB
1
?
A:
[87-492]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
V
A
I
F
S
--
V
--------
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
---
S
M
L
I
----
V
---
N
L
-
L
---
A
V
T
G
G
C
F
M
G
L
CKVAKS
V
E
M
------------------
L
---------------------
I
L
---
G
---------
R
------------------
L
V
I
G
L
F
C
G
L
----
C
T
--
G
F
V
P
----
M
Y
I
G
------
E
I
S
---
P
T
A
L
R
-
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
----------
A
------------
Q
I
F
G
L
E
F
I
-
L
----
G
-----------------------------
S
EEL--------
W
P
L
-
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
--
F
C
P
E
S
P
R
---------
F
L
L
I
----
N
R
K
E
E
E
N
A
K
Q
I
L
Q
--
R
L
W
G
T
--
Q
-
D
V
S
Q
D
I
Q
E
-------------------
M
K
D
E
S
A
R
M
S
Q
E
K
QV
T
V
--
L
E
L
F
R
V
S
S
Y
---
R
----
Q
P
I
I
I
S
I
V
L
Q
----
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
----
Y
S
-
T
G
-----
I
-
F
-----
K
---
D
A
------
G
--
V
Q
E
P
I
-
Y
A
T
I
G
A
G
-----
V
V
N
T
I
-
F
T
--------
V
V
S
L
F
-
L
V
--
E
R
A
G
R
R
T
L
--
H
-
M
I
G
L
G
G
M
--
A
---
F
C
-
S
T
--
L
M
T
V
S
L
L
L
K
D
N
Y
---------
N
G
---
M
S
F
V
-------
C
I
G
A
I
L
--
V
-
F
V
A
--------
F
F
E
I
GPGPIPWF
I
V
A
E
L
-------------
F
SQG
P
R
P
A
A
M
A
V
A
G
C
S
--------
N
W
T
S
N
F
--
L
-
V
G
----
L
L
F
P
S
-
A
A
-
H
-
Y
L
G
A
Y
V
F
--------
I
--------
I
F
T
G
F
L
I
T
F
-
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
------------------
22
Fugue
81.12
21%
-96
- C2 -
4QIQ
-
XYLE_ECOLI
A:
[7-470]
------------------S
Y
I
F
S
I
T
L
V
A
T
L
G
----
G
L
L
F
G
Y
D
T
A
----
V
I
S
G
T
----------
V
E
S
L
N
T
V
F
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
----
G
F
C
V
-------
A
S
A
L
I
G
C
I
I
G
G
A
L
G
G
-----------
Y
C
S
N
R
F
G
R
--------------------------------------------------
R
D
S
L
K
I
A
A
V
L
F
F
I
--
S
--------
G
V
G
S
A
W
P
E
L
G
F
T
S
I
N
P
D
N
T
V
---
P
--------------
V
---
Y
L
A
G
-------------------------------------------------------
Y
V
---
P
---------
E
------------------
F
V
I
--
Y
---
R
I
I
G
G
I
--
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
---
P
A
H
I
R
-
G
K
--
L
V
S
F
N
Q
F
A
I
I
F
G
Q
----------
L
------------
L
V
Y
C
V
N
Y
F
-
I
----
A
-----------------------------
R
SGD
A
S
W
L
N
T
D
G
W
R
Y
-
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
Y
--
T
V
P
E
S
P
R
---------
W
L
M
------
T
L
A
T
Q
A
V
Q
E
I
K
H
S
L
D
R
L
L
M
--
F
-
G
V
G
V
I
V
I
G
V
M
L
S
--------------
I
F
Q
Q
F
V
G
-------------------------------------------
I
N
V
V
L
Y
Y
A
P
E
V
F
K
----
T
L
-
G
------
A
-
S
-----
T
---
D
I
------
A
--
L
L
Q
T
I
-
I
-----
V
-----
G
V
I
N
L
-
T
F
--------
T
V
L
A
I
-
M
T
V
D
K
F
G
R
K
P
L
Q
--
I
-
I
---
G
A
L
--
G
---
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
---------
G
I
---
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
G-
P
-
V
C
W
--------
V
L
L
-----------
S
E
I
-------------
F
---
P
N
A
I
R
G
K
A
L
A
I
A
--------
V
A
A
Q
W
L
A
N
Y
-
F
V
----
S
W
T
F
P
-
M
M
-
D
-
K
N
S
W
L
V
A
--------
H
FHNGF
S
Y
W
I
Y
G
C
M
G
V
L
A
-
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
------------------------------
8
PsiBlast_PDB
80.63
22%
-104
- C2 -
4ZWC
3
?
A:
[87-492]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
V
A
I
F
S
--
V
--------
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
---
S
M
L
I
----
V
---
N
L
-
L
---
A
V
T
G
G
C
F
M
G
L
CKVAKS
V
E
M
------------------
L
---------------------
I
L
---
G
---------
R
------------------
L
V
I
G
L
F
C
G
L
----
C
T
--
G
F
V
P
----
M
Y
I
G
------
E
I
S
---
P
T
A
L
R
-
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
----------
A
------------
Q
I
F
G
L
E
F
I
-
L
----
G
-----------------------------
S
EEL--------
W
P
L
-
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
--
F
C
P
E
S
P
R
---------
F
L
L
I
----
N
R
K
E
E
E
N
A
K
Q
I
L
Q
--
R
L
W
G
T
--
Q
-
D
V
S
Q
D
I
Q
E
-------------------
M
K
D
E
S
A
R
M
S
Q
E
K
QV
T
V
--
L
E
L
F
R
V
S
S
Y
---
R
----
Q
P
I
I
I
S
I
V
L
Q
----
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
----
Y
S
-
T
G
-----
I
-
F
-----
K
---
D
A
------
G
--
V
Q
E
P
I
-
Y
A
T
I
G
A
G
-----
V
V
N
T
I
-
F
T
--------
V
V
S
L
F
-
L
V
--
E
R
A
G
R
R
T
L
--
H
-
M
I
G
L
G
G
M
--
A
---
F
C
-
S
T
--
L
M
T
V
S
L
L
L
K
D
N
Y
---------
N
G
---
M
S
F
V
-------
C
I
G
A
I
L
--
V
-
F
V
A
--------
F
F
E
I
GPGPIPWF
I
V
A
E
L
-------------
F
SQG
P
R
P
A
A
M
A
V
A
G
C
S
--------
N
W
T
S
N
F
--
L
-
V
G
----
L
L
F
P
S
-
A
A
-
H
-
Y
L
G
A
Y
V
F
--------
I
--------
I
F
T
G
F
L
I
T
F
-
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
H
------------------
4
PsiBlast_PDB
80.50
21%
-110
- C2 -
4JA4
-
XYLE_ECOLI
A:
[26-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
T
A
V
I
S
G
T
V
E
S
L
-
N
T
V
F
V
A
P
Q
N
L
S
E
S
A
A
N
S
L
L
--
G
F
C
V
A
S
A
LI
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
---
S
L
K
I
----
A
---
A
V
L
F
---
F
I
S
G
------------
V
G
S
------------------
A
W
PELGF
T
S
I
N
P
D
N
T
V
PVYLAG
Y
V
---
P
---------
E
------------------
F
V
I
--
Y
---
R
I
I
G
G
I
--
G
V
G
L
----
A
S
M
L
S
P
M
Y
I
A
E
L
A
---
P
A
H
I
R
-
G
K
--
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
------------
R
S
G
D
A
S
W
L
-
N
----
T
-----------------------------
D
G
----------
W
R
Y
-
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
-
L
Y
--
T
V
P
E
S
P
R
---------
W
L
M
--------
Q
E
Q
A
E
G
I
L
R
K
---
I
M
G
N
--
T
-
L
A
T
Q
A
V
Q
E
-------------------
I
K
H
S
L
D
H
G
------------
M
F
G
V
G
V
I
V
I
G
V
----
M
L
S
I
F
Q
Q
F
V
G
----
I
N
V
V
L
Y
Y
A
P
E
V
---------------------------------------
L
L
Q
T
I
-
I
V
----
G
-----
V
I
N
L
T
-
F
T
--------
V
L
A
I
M
-
T
V
--
D
K
F
G
R
K
P
L
--
Q
I
I
---
G
A
L
--
G
---
M
A
I
G
M
--
F
S
L
G
T
A
F
Y
T
Q
A
P
---------
G
I
---
V
A
L
L
S
M
L
F
Y
V
A
A
F
A
M
S
W
GP
V
-
C
W
V
--------
L
L
------------
S
E
I
-------------
F
---
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
W
T
F
P
M
-
M
D
----
K
N
S
W
---------
N
G
F
S
Y
--------
W
--------
I
Y
G
C
M
G
V
L
A
-
A
L
F
M
W
K
F
V
P
E
T
K
G
----
K
T
L
E
E
L
E
A
L
W
E
------------------
10
PsiBlast_PDB
80.40
22%
-105
- C2 -
5C65
8
?
A:
[65-469]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
V
A
I
F
S
--
V
--------
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
---
S
M
L
I
----
V
---
N
L
-
L
---
A
V
T
G
G
C
F
M
G
L
C
KVAKS
V
E
M
------------------
L
---------------------
I
L
---
G
---------
R
------------------
L
V
I
G
L
F
C
G
L
----
C
T
--
G
F
V
P
----
M
Y
I
G
------
E
I
S
---
P
T
A
L
R
-
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
----------
A
------------
Q
I
F
G
L
E
F
I
-
L
----
G
-----------------------------
S
EEL--------
W
P
L
-
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
-
L
P
--
F
C
P
E
S
P
R
---------
F
L
L
I
----
N
R
K
E
E
E
N
A
K
Q
I
L
Q
--
R
L
W
G
T
--
Q
-
D
V
S
Q
D
I
Q
E
-------------------
M
K
D
E
S
A
R
M
S
Q
E
K
QV
T
V
--
L
E
L
F
R
V
S
S
Y
---
R
----
Q
P
I
I
I
S
I
V
L
Q
----
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
----
Y
S
-
T
G
-----
I
-
F
-----
K
---
D
A
------------
P
I
-
Y
A
T
I
G
A
G
-----
V
V
N
T
I
-
F
T
--------
V
V
S
L
F
-
L
V
--
E
R
A
G
R
R
T
L
--
H
-
M
I
G
L
G
G
M
--
A
---
F
C
-
S
T
--
L
M
T
V
S
L
L
L
K
D
----------------
M
S
F
V
-------
C
I
G
A
I
L
--
V
-
F
V
A
--------
F
F
E
I
GPGPIPWF
I
V
A
E
L
-------------
F
SQG
P
R
P
A
A
M
A
V
A
G
C
S
--------
N
W
T
S
N
F
--
L
-
V
G
----
L
L
F
P
S
-
A
A
-
H
-
Y
L
G
A
Y
V
F
--------
I
--------
I
F
T
G
F
L
I
T
F
-
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
A
F
E
G
Q
A
-------------------
32
HHSearch
64.00
17%
-113
- C2 -
3WDO
-
?
A:
[39-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
-
Q
G
A
S
---
E
A
L
I
G
I
A
I
G
I
Y
G
--
L
--------
T
Q
A
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
K
P
---
L
I
V
G
----
G
---
L
A
V
F
---
A
A
G
S
------------
V
I
A
------------------
A
---------------------
L
S
---
D
---------
S
------------------
I
W
G
--
I
I
L
G
R
A
L
Q
G
S
--
G
A
------
I
A
A
A
V
M
A
L
L
S
D
L
T
---
R
E
Q
N
R
-
T
K
--
A
M
A
F
I
G
V
S
F
G
I
T
F
----------
A
------------
I
A
M
V
L
G
P
I
-
I
----
T
H
K
L--------------------------
G
-----------
L
H
A
-
L
F
W
M
I
A
I
L
A
T
T
G
I
A
L
T
I
W
--
V
V
P
N
S
S
T
---------
H
V
L
N
----
R
E
S
-------------------------------------------------------
G
M
V
K
G
--
S
F
--
S
K
V
L
A
E
P
R
L
---
L
----
K
L
N
F
G
I
M
C
L
H
----
M
L
L
M
S
T
F
V
A
L
P
G
Q
----
L
A
-
D
------
A
-
G
-----
F
---
P
A
A
E
H
W
K
V
Y
--
L
A
T
M
L
-
I
-----
A
-----
F
G
S
V
V
-
P
F
--------
I
I
Y
A
E
-
V
K
--
R
K
M
K
Q
--
V
--
F
-
V
---
F
C
V
--
G
---
L
I
-
V
V
--
A
E
I
V
L
W
N
A
-
Q
T
Q
---------
F
W
---
Q
L
V
V
G
V
Q
L
F
F
V
A
F
N
L
M
E
--
A
-
L
L
P
--------
S
L
I
-----------
S
K
E
-------------
S
---
P
A
G
Y
K
G
T
A
M
G
V
Y
--------
S
T
S
Q
F
L
G
V
A
-
I
G
----
G
S
L
G
G
W
I
D
-
G
M
F
D
G
Q
G
V
F
--------
L
--------
A
G
A
M
L
A
A
V
W
-
L
A
V
A
S
T
M
K
E
P
P
Y
V
S
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
T
E
G
V
K
E
V
L
I
A
31
HHSearch
61.26
13%
-110
- C2 -
1PW4
-
GLPT_ECOLI
A:
[51-440]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
P
Y
L
-
V
E
-
Q
G
F
S
---
R
G
D
L
G
F
A
L
S
G
I
S
--
I
--------
A
Y
G
F
S
K
F
I
M
G
S
V
S
D
R
S
N
P
R
V
---
F
L
P
A
----
G
---
L
I
L
A
---
A
A
V
M
------------
L
F
M
------------------
G
---------------------
F
V
---
P
W
A
T
S
-----
S
------------------
I
A
V
--
M
F
V
L
L
F
L
C
G
W
--
F
Q
G
M
----
G
W
P
P
C
G
R
T
M
V
H
W
W
---
S
Q
K
E
R
-
G
G
--
I
V
S
V
W
N
C
A
H
N
V
G
G
----------
G
------------
I
P
P
L
L
F
L
L
-
G
M
AWF
N
-----------------------------
D
-----------
W
H
A
-
A
L
Y
M
P
A
F
C
A
I
L
V
A
L
F
A
F
A
--
M
M
R
D
T
P
Q
---------
S
C
G
L
----
P
P
I
E
E
Y
K
N
D
--------------------------------------------------
T
A
K
Q
I
-
F
M
--
Q
Y
V
L
P
N
K
L
L
---
W
----
Y
I
A
I
A
N
V
F
V
Y
----
L
L
R
Y
G
I
L
D
W
S
P
T
Y
----
L
K
-
E
------
V
K
H
FA
L
--
D
---
K
S
------
S
--
W
A
Y
F
L
-
Y
-----
E
-----
Y
A
G
I
P
-
G
T
--------
L
L
C
G
W
-
M
S
--
D
K
V
F
R
G
N
R
--
G
-
A
---
T
G
V
--
F
F
M
T
L
V
-
T
I
--
A
T
I
V
Y
W
M
N
P
A
G
N
---------
P
T
---
V
D
M
I
C
M
I
V
I
G
F
L
I
Y
G
P
V
--
M
-
L
I
G
--------
L
H
A
-----------
L
E
L
-------------
A
---
P
K
K
A
A
G
T
A
A
G
F
T
--------
G
L
F
G
Y
L
G
G
S
V
A
A
----
S
A
I
V
G
Y
T
V
-
D
F
F
G
W
D
G
G
F
--------
M
--------
V
M
I
G
G
S
I
L
A
-
V
I
L
L
I
V
V
M
I
G
E
K
R
R
H
E
Q
L
L
Q
E
L
V
P
----------------------
9
PsiBlast_PDB
60.79
23%
-101
- C2 -
4LDS
-
?
A:
[147-427]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
------------
Y
L
V
N
Y
A
F
A
D
I
----
E
-----------------------------
G
-----------
W
R
W
-
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
-
I
Y
--
F
M
P
E
S
P
R
---------
W
L
-
L
----
E
N
R
N
E
E
A
A
R
Q
V
M
K
I
T
Y
D
D
S
E
I
D
K
-
E
L
K
E
M
K
E
I
N
A
I
S
--------------
E
S
T
W
T
V
I
K
S
P
W
L
G
--
R
I
--
L
I
V
G
C
I
F
A
I
---
F
----
Q
Q
F
I
G
I
N
A
V
I
----
F
-----
Y
S
S
S
I
F
A
----
K
A
-
G
------
L
-
G
-----
E
---
A
A
------
S
--
I
L
G
S
V
G
I
-----
G
-----
T
I
N
V
L
-
V
T
--------
I
V
A
I
F
-
V
V
--
D
K
I
D
R
K
K
L
--
L
-
V
---
G
G
N
I
G
M
---
I
A
-
S
L
--
L
I
M
A
I
L
I
W
T
I
G
I
---------
A
S
S
A
W
I
I
I
V
C
L
S
L
F
I
V
F
F
G
I
S
W
--
G
P
V
L
W
--------
V
M
L
-----------
P
E
L
-------------
F
---
P
M
R
A
R
G
A
A
T
G
I
S
--------
A
L
V
L
N
I
G
T
L
-
I
V
----
S
L
F
---------
F
P
I
L
S
D
ALSTEW
V
F
L
--------
I
F
A
F
I
G
V
L
A
-
M
I
F
V
I
K
F
L
P
E
T
R
G
---------------------------------
27
Fugue
58.69
12%
-112
- C1 -
4AEE
-
?
A:
[1-696]
MYKII
G
R
E
I
Y
GK
G
R
K
G
R
Y
I
V
K
F
T
R
H
W
P
Q
Y
A
K
NIYL
I
G
E
F
T
S
L
Y
P
GF
V
K
L
R
K
I
E
E
Q
G
I
V
Y
L
K
L
W
P
G
E
Y
G
Y
G
F
Q
I
D
N
D
F
E
N
V
L
D
P
D
N
E
E
K
K
C
V
H
T
S
F
F
P
E
Y
K
K
C
L
S
K
L
V
I
K
E
P
D
N
P
L
D
K
I
I
H
I
EESGF
I
H
K
F
N
G
E
I
I
I
R
L
I
A
P
T
E
I
N
E
P
L
I
D
L
G
N
E
I
R
E
P
L
T
K
H
V
--
V
G
D
N
I
V
Y
Q
Y
I
I
P
S
-
R
S
I
L
R
Y
R
F
I
F
N
Y
N
D
K
K
L
F
Y
G
D
E
--------
G
V
S
E
N
S
S
Y
I
V
V
N
S
K
Y
I
P
G
V
D
---
K
P
R
W
YM
G
T
V
---
Y
Y
Q
I
FID
S
F
D
N
------------
G
D
P
------------------
N
---------------------
N
D
---
P
---------
P
N
R
I
K
KTVPREYGYYGGD
L
A
G
I
--
M
K
H
I
D
H
L
E
D
L
--
G
V
E
T
----
I
Y
L
---
T
P
I
F
S
S
T
---
S
Y
H
R
Y
D
T
I
--
D
Y
K
S
I
D
K
Y
L
G
-
T
M
----------
E
------------
D
F
E
K
L
V
Q
V
-
L
----
H
-----------------------------
S
------------
R
K
-
I
K
I
V
L
D
I
T
M
H
H
T
N
P
C
-
N
E
--
L
F
V
K
A
L
R
E
GENSPYWE
M
F
S
F
----
L
S
P
P
-
P
K
E
I
V
E
L
M
L
K
Y
I
D
G
E
--
E
C
R
S
R
E
L
Y
K
L
D
Y
F
R
N
NKPFYEAFFNIWL
M
A
K
F
N
H
D
N
P
R
T
V
D
--
Y
F
--
I
D
I
T
K
F
W
I
D
---
K
GID
G
F
R
I
D
V
A
M
G
I
H
----
Y
S
W
M
K
Q
Y
Y
E
Y
I
K
N
----
T
Y
-
P
------------------
D
F
------
L
--
V
L
G
E
L
-
A
-----
E
-----
N
P
R
I
Y
-
M
D
YFDSAMN
Y
Y
L
R
K
A
-
I
L
--
E
L
L
I
Y
K
R
I
--
D
-
L
---
N
E
F
--
I
---
S
R
-
I
N
--
N
V
Y
A
Y
I
P
H
Y
K
A
L
S
LYNMLGSH
D
V
---
P
R
I
K
S
M
V
Q
N
N
K
L
L
K
L
M
Y
--
V
-
L
I
F
A
LP
G
S
P
V
I
Y
Y
G
-----------
D
E
I
G
L
E
G
G
R
DPDNRRP
M
---
I
W
D
R
G
N
W
D
L
E
L
Y
--------
E
H
I
K
K
L
I
R
I
-
Y
K
----
S
C
R
S
M
-
R
H
-
G
-
Y
F
L
V
E
N
L
GSN
L
----
L
--------
F
I
K
R
W
I
N
N
E
-
E
I
I
F
L
L
N
V
S
S
K
D
I
S
V
D
L
K
Y
S
F
D
I
Y
N
E
K
N
V
L
L
R
G
Y
G
F
L
I
L
G
S
K
P
C
N
I
28
Fugue
57.53
12%
-98
- C2 -
2GFP
-
EMRD_ECOLI
A:
[9-383]
----------------------------------------
L
L
L
M
----
L
V
L
L
V
A
V
G
Q
M
A
Q
T
I
Y
I
P
A
I
A
D
M
A
R
D
-------------------------------------------------------------------------------------------------------------
L
N
V
R
E
G
A
V
Q
S
V
M
G
A
Y
L
--
L
--------
T
Y
G
V
S
Q
L
F
Y
G
P
I
S
D
R
V
G
R
R
P
---
V
I
L
V
----
G
---
M
S
I
F
---
M
L
A
T
------------
L
V
A
------------------
V
---------------------
T
T
---
S
---------
S
------------------
L
T
V
--
L
I
A
A
S
A
M
Q
G
M
--
G
T
G
V
----
G
G
V
M
A
R
T
L
P
R
D
L
Y
E
R
T
Q
L
R
H
A
-
N
S
--
L
L
N
M
G
I
L
V
S
P
L
L
A
----------
P
------------
L
I
G
G
L
L
D
T
-
M
----
W
-----------------------------
N
-----------
W
R
A
C
Y
L
F
L
L
V
L
C
A
G
V
T
F
S
M
-
A
R
--
W
M
P
E
T
R
P
---------
V
D
A
P
----
R
T
R
L
L
T
S
Y
K
T
L
F
G
N
S
G
F
N
C
Y
--
L
-
L
M
L
I
G
G
L
A
G
I
A
A
--------------
F
E
A
C
S
---------------------------------------------------------------
G
-
V
------
L
-
M
-----
G
---
A
V
------
L
--
G
L
S
S
M
-
T
-----
V
-----
S
I
L
F
I
-
L
P
--------
I
P
A
A
F
-
F
G
--
A
W
F
A
G
R
P
N
--
K
-
R
---
F
S
T
--
L
---
M
W
-
Q
S
--
V
I
C
C
L
L
--
A
G
L
L
---------
M
W
---
I
P
D
W
F
G
V
M
N
V
W
T
L
L
V
P
A
--
A
-
L
F
F
--------
F
G
A
-----------
G
M
L
-------------
F
---
P
L
A
T
S
G
A
M
E
P
F
P
--------
F
L
A
G
T
A
G
A
L
-
V
G
----
G
L
Q
N
I
-
G
S
-
G
-----
V
L
A
--------
S
--------
L
S
A
M
L
P
Q
T
G
-
Q
G
S
L
G
L
L
M
T
L
M
G
L
L
I
V
L
C
W
L
P
L
------------------------
33
HHSearch
56.75
13%
-99
- C2 -
3O7Q
1
FUCP_ECOLI
A:
[45-406]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
I
L
L
P
Q
F
Q
Q
A
-
F
T
L
T
---
N
F
Q
A
G
L
I
Q
S
A
F
Y
--
F
--------
G
Y
F
I
I
P
I
P
A
G
I
L
M
K
K
L
S
Y
K
A
---
G
I
I
T
----
G
---
L
F
L
Y
---
A
L
G
A
------------
A
L
F
------------------
W
---------------------
P
A
A
E
I
M
---------
N
------------------
Y
T
L
--
F
L
V
G
L
F
I
I
A
A
--
G
L
G
C
----
L
E
T
A
A
N
P
F
V
T
V
L
G
---
P
E
S
S
G
-
H
F
--
R
L
N
L
A
Q
T
F
N
S
F
G
A
----------
I
------------
I
A
V
V
F
G
Q
S
-
L
----
I
LSNVPHQS
Q
D
V
L
D
K
MS
P
E
Q
L
S
A
Y
K
H
S
L
V
L
S
-----------
V
Q
T
-
P
Y
M
I
I
V
A
I
V
L
L
V
A
L
L
-
I
M
L
T
K
F
P
A
L
Q
S
---------
D
--------
N
H
S
D
A
--------------------------------------------------
K
Q
G
S
F
S
A
--
S
L
--
S
R
L
A
R
I
R
H
W
---
R
----
W
A
V
L
A
Q
F
C
Y
V
----
G
A
Q
T
A
C
W
S
Y
L
I
R
Y
----
A
V
E
E
I-----
P
-
G
-----
M
T
A
G
F
A
------
A
--
N
Y
L
T
G
-
T
-----
M
-----
V
C
F
F
I
-
G
R
--------
F
T
G
T
W
-
L
I
--
S
R
F
A
P
H
K
V
--
L
-
A
---
A
Y
A
--
L
---
I
A
-
M
A
--
L
C
L
I
S
A
F
A
G
-
G
----------
H
V
---
G
-
L
I
A
L
T
L
C
S
A
F
M
S
I
Q
Y
--
P
-
T
I
F
--------
S
L
G
-----------
I
K
N
-------------
L
---
G
Q
D
T
K
-
Y
G
S
S
F
I
---------
V
M
T
I
I
G
G
G
-
I
V
----
T
P
V
M
G
F
V
S
-
D
-
A
A
G
N
I
P
T
--------
A
--------
E
L
I
P
A
L
C
F
A
-
V
I
F
I
F
A
R
F
R
S
Q
T
----------------------------------
11
PsiBlast_PDB
56.10
23%
-96
- C2 -
4PYP
1
GTR1_HUMAN
A:
[48-353]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
H
R
Y
G
E
S
I
L
P
T
T
L
T
T
L
-
W
S
L
----------
S
V
A
I
F
S
--
V
--------
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
----
L
---
A
F
V
S
---
A
V
L
M
------------
G
F
S
------------------
K
---------------------
L
G
---
K
---------
S
------------------
F
E
M
--
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
----
G
F
V
P
M
Y
V
G
E
V
S
P
T
---
A
L
R
G
A
-
L
G
--
T
L
H
Q
L
G
I
V
V
G
I
L
I
----------
A
------------
Q
V
F
G
L
D
S
I
-
M
----
G
-----------------------------
N
KDL--------
W
P
L
-
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
-
L
P
--
F
C
P
E
S
P
R
---------
F
L
L
I
NRNE
E
N
R
A
K
S
V
L
K
K
L
R
G
T
A
D
V
T
-
H
--
D
-----------
L
Q
--------------
E
M
K
E
E
S
R
Q
M
M
R
E
K
--
K
V
T
I
L
E
L
F
R
S
P
A
Y
---
R
----
Q
P
I
L
I
A
V
V
L
Q
----
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
----
Y
S
T
S
------
I
-
F
-----
E
---
K
A
------
G
--
V
Q
Q
P
V
-
Y
A
T
I
G
S
G
-----
I
V
N
T
A
-
F
T
--------
V
V
S
L
F
-
V
V
--
Q
R
A
G
R
R
T
L
--
H
L
I
---
G
L
A
--
G
---
M
A
-
G
C
--
A
I
L
M
T
I
A
L
A
L
L
E
---------
Q
L
---
P
W
M
S
Y
L
S
I
V
A
I
F
G
F
V
A
F
--
F
-
E
V
G
--------
P
G
P
-----------
I
P
W
-------------
F
---
I
V
A
E
L
F
S
Q
G
P
R
P
--------
A
A
I
A
V
A
G
F
S
-
N
W
----
T
S
N
F
I
-
V
G
-
M
-
C
F
Q
Y
V
E
Q
--------
L
--------
C
G
P
Y
V
F
I
I
F
-
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
----------------------------
24
Fugue
53.45
13%
-79
- C2 -
3JA7
-
?
A:
[1-447]
-------------------
N
W
I
S
E
L
I
D
T
Y
R
N
------
L
M
N
N
Y
E
---------------
V
D
N
A
V
S
E
I
V
S
D
A
I
V
--------
Y
E
D
D
T
E
----
V
--------------
V
A
L
N
L
D
K
S
K
F
S
-----------
P
K
I
K
N
M
M
L
D
E
F
S
D
V
L
N
H
L
---
S
F
Q
R
K
G
S
D
H
F
R
R
W
Y
V
--
D
S
R
I
F
F
H
K
I
I
D
P
K
-
R
----
P
K
E
G
I
K
E
L
R
R
L
-
D
P
--
R
--------
Q
V
Q
Y
V
Y
F
I
Y
D
T
A
H
E
S
Y
A
--------------
C
---
D
G
R
M
---
Y
E
A
G
------------
T
K
I
------------------
K
---------------------
I
P
---
K
---------
A
------------------
A
V
V
--
Y
A
H
--------------------------------------------
S
G
L
V
D
C
C
---
G
K
----------
N
------------
I
I
G
Y
L
H
R
A
-
V
----
K
-----------------------------
P
-----------
A
N
Q
-
L
K
L
L
E
D
A
V
V
I
Y
R
I
T
R
-
A
-----
P
D
R
R
V
---------
W
Y
V
D
----
T
G
N
M
P
A
R
K
A
A
E
H
M
Q
H
V
M
N
T
M
--
K
-
N
------
R
V
V
Y
D
--------------
A
S
T
G
K
I
K
N
Q
Q
H
N
M
--
S
M
--
T
E
D
Y
W
L
Q
R
R
---
D
----
G
K
A
------------
V
T
E
V
D
T
L
P
G
A
D
N
----
T
G
-
N
------
M
-
E
-----
D
---
I
R
------
W
--
F
R
Q
A
L
-
Y
-----
M
-----
A
---
L
-
R
V
--------
P
L
S
R
I
-
P
Q
--
D
Q
Q
G
G
V
M
F
--
D
-
S
---
G
T
S
--
I
---
T
R
-
D
E
--
L
T
F
A
K
F
I
R
E
L
Q
H
---------
K
F
---
E
E
V
F
L
D
P
L
K
T
N
L
L
L
K
G
I
--
I
-
T
E
D
--------
E
W
N
-----------
D
E
I
-------------
N
---
N
I
K
I
E
F
H
R
D
--------------
S
Y
F
A
E
L
-
K
E
----
A
E
I
L
E
-
R
R
-
I
-
N
M
L
T
M
A
E
--------
P
--------
F
I
G
K
------------
Y
I
S
H
R
T
A
M
K
D
I
L
Q
M
T
D
E
E
I
E
Q
E
A
K
Q
I
E
E
E
S
K
E
A
R
F
Q
D
---
35
HHSearch
51.61
13%
-90
- C2 -
2CFQ
-
LACY_ECOLI
A:
[28-395]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
F
P
I
W
L
H
D
I
N
H
I
S
---
K
S
D
T
G
I
I
F
A
A
I
S
--
L
--------
F
S
L
L
F
Q
P
L
F
G
L
L
S
D
K
L
G
L
R
K
---
Y
L
L
W
----
I
I
T
G
M
L
V
M
---
F
A
P
F
------------
F
I
F
------------------
I
---------------------
F
G
---
P
---------
L
L
-----------------
Q
Y
N
--
I
L
V
G
S
I
V
G
G
I
--
Y
L
G
F
CFNA
G
A
P
A
V
E
A
F
I
E
K
V
S
---
R
--
R
S
-
N
F
--
E
F
G
R
A
R
M
F
G
C
V
G
W
----------
A
------------
L
G
A
S
I
V
G
I
-
M
----
F
T
I
---------------------------
N
-----------
N
Q
F
-
V
F
W
L
G
S
G
C
A
L
I
L
A
V
L
-
L
F
--
F
A
K
T
D
A
P
---------
S
S
------
A
T
V
--
A
N
A
V
--------------------------------------------
G
A
N
H
S
A
F
S
L
K
--
L
A
--
L
E
L
F
R
Q
P
K
L
---
W
----
F
L
S
L
Y
V
I
G
V
S
----
C
T
Y
D
V
F
D
Q
Q
F
A
N
F
----
F
T
-
S
F
FAT
G
E
Q
-
G
T
----
R
---
V
F
------
G
--
Y
V
T
T
M
-
G
-----
E
-----
L
L
N
A
S
-
I
M
--------
F
F
A
P
L
-
I
I
--
N
R
I
G
G
K
N
A
--
L
-
L
---
L
A
G
--
T
---
I
M
-
S
V
--
R
I
I
G
S
S
F
A
T
S
-----------
A
L
---
E
V
V
I
L
K
T
L
H
M
F
E
V
P
F
L
L
--
V
-
G
C
F
--------
K
Y
I
-----------
T
S
Q
-------------
F
---
E
V
R
F
S
A
T
I
Y
L
V
C
F-------
C
F
F
K
Q
L
A
M
I
-
F
M
----
S
V
L
A
G
N
M
Y
E
S
-
I
G
F
Q
G
A
Y
--------
L
--------
V
L
G
L
V
A
L
G
F
-
T
L
I
S
V
F
T
L
S
G
P
G
P
L
S
L
L
R
R
Q
V
N
E
V
A
---------------------