@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UT1_HUMAN: (2015-12-12 )
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL
Atome Classification :
(20 SA)
------------------------------------------.........---10........20........30.-....----------...40........50--...--.....-------60........70........80........90........100-----.......110.......120.......130-------....-..--------..140..---------......------.150--.....-----------------...160-----------.......-..170....-------...180...----.-...190--.---------------..--------------....200.----...--...210.......220...-------....230.......240..---------.....250.....------------------..260.......270.---------...---...---------280....----------...290.......300----------------------........310...-------.....320--------....-------...330.......----340..-----.....350.......360..------.....370....----------...-----380.......----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------MEDSP
T
M
V
R
---VDSP
T
M
VRGENQVSPCQGRRC
F
P
-
K
A
L
G
----------
Y
VTG
D
M
K
E
L
A
N
QLKD--K
P
V
--
V
L
Q
F
I
-------
D
W
I
L
R
G
I
S
Q
V
V
F
VNNPV
S
G
I
L
I
L
V
G
L
L
VQNP
W
W
A
L
T
G
W
L
G
T
V
V
-----
S
T
L
M
A
L
L
L
SQ
D
R
S
L
I
A
S
G
LYGY
N
A
T
L
V
G
V
--------
L
M
A
V
-FS--------DKG--
D
Y
---------
F
W
W
L
L
L
------
P
V
C
---
A
M
SMT-----------------
C
P
I
F
-------------
S
S
A
L
N
S
M
-
L
S
KWDL
P
V
F
-------
T
L
P
F
N
M
A
L
S
----
M
-
Y
LSATG--H---------------YN--------------PFF
P
A
K
L
V
----
I
P
I--TTAPNISW
S
D
L
S
A
L
E
L
L
K
S-------IPV
G
V
G
Q
I
YGCDNPWT
G
G
I
---------
F
L
G
A
I
L
LSS
P
L
M
C
------------------
L
H
A
A
I
G
S
L
L
G
I
AAGLS---------LSA---
P
F
E
---------
D
I
Y
F
G
L
W----------GFNS
S
L
A
C
I
AMG
G
M
F
-----------------------
M
A
L
T
W
Q
T
H
L
-
L
A
L
G
-------
C
A
L
F
T
A
Y
L
--------
G
V
G
M
-------
A
N
F
M
A
E
VGLPAC
T
----
W
P
F
C
L
-----
A
T
L
L
F
L
I
MTTKNS
N
I
Y
KMPL------SKVTYPEE
N
R
I
F
----------
Y
L
Q
-----
A
K
K
R
M
VESPL----------------------------------
24
PsiBlast_CBE
99.22
79%
-155
- C3 -
4EZC
9
UT1_BOVIN
B:
[31-376]
---------------------------------------------------------------------------------
G
----------
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
--
K
P
Q
--
A
L
Q
F
V
-------
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
G
L
L
V
Q
N
P
W
C
A
L
N
G
C
V
G
T
V
V
-----
S
T
L
T
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
--------
L
M
A
I
-
Y
S
--------
D
K
G
--
N
Y
---------
F
W
W
L
L
F
------
P
V
S
---
A
M
S
M
T
-----------------
C
P
V
F
-------------
S
S
A
L
N
S
V
-
L
S
K
W
D
L
P
V
F
-------
T
L
P
F
N
M
A
L
S
----
M
-
Y
L
S
A
T
G
--
H
---------------
Y
N
--------------
P
F
F
P
S
T
L
I
----
T
P
V
--
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
-------
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
---------
F
L
G
A
I
L
L
S
S
P
L
M
C
------------------
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
---------
L
S
A
---
P
F
E
---------
D
I
Y
A
G
L
W
----------
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
-----------------------
M
A
L
T
W
Q
T
H
L
-
L
A
L
A
-------
C
A
L
F
T
A
Y
L
--------
G
A
S
M
-------
S
H
V
M
A
V
V
G
L
P
S
G
T
----
W
P
F
C
L
-----
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
------
S
K
V
T
Y
P
E
E
N
R
I
F
----------
Y
L
Q
-----
S
R
------------------------------------------
23
PsiBlast_CBE
99.13
79%
-153
- C3 -
4EZC
11
UT1_BOVIN
C:
[31-376]
---------------------------------------------------------------------------------
G
----------
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
--
K
P
Q
--
A
L
Q
F
V
-------
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
G
L
L
V
Q
N
P
W
C
A
L
N
G
C
V
G
T
V
V
-----
S
T
L
T
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
--------
L
M
A
I
-
Y
S
--------
D
K
G
--
N
Y
---------
F
W
W
L
L
F
------
P
V
S
---
A
M
S
M
T
-----------------
C
P
V
F
-------------
S
S
A
L
N
S
V
-
L
S
K
W
D
L
P
V
F
-------
T
L
P
F
N
M
A
L
S
----
M
-
Y
L
S
A
T
G
--
H
---------------
Y
N
--------------
P
F
F
P
S
T
L
I
----
T
P
V
--
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
-------
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
---------
F
L
G
A
I
L
L
S
S
P
L
M
C
------------------
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
---------
L
S
A
---
P
F
E
---------
D
I
Y
A
G
L
W
----------
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
-----------------------
M
A
L
T
W
Q
T
H
L
-
L
A
L
A
-------
C
A
L
F
T
A
Y
L
--------
G
A
S
M
-------
S
H
V
M
A
V
V
G
L
P
S
G
T
----
W
P
F
C
L
-----
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
------
S
K
V
T
Y
P
E
E
N
R
I
F
----------
Y
L
Q
-----
S
R
------------------------------------------
2
PsiBlast_PDB
99.11
79%
-154
- C3 -
4EZD
10
UT1_BOVIN
A:
[31-375]
---------------------------------------------------------------------------------
G
----------
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
--
K
P
Q
--
A
L
Q
F
V
-------
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
G
L
L
V
Q
N
P
W
C
A
L
N
G
C
V
G
T
V
V
-----
S
T
L
T
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
--------
L
M
A
I
-
Y
S
--------
D
K
G
--
N
Y
---------
F
W
W
L
L
F
------
P
V
S
---
A
M
S
M
T
-----------------
C
P
V
F
-------------
S
S
A
L
N
S
V
-
L
S
K
W
D
L
P
V
F
-------
T
L
P
F
N
M
A
L
S
----
M
-
Y
L
S
A
T
G
--
H
---------------
Y
N
--------------
P
F
F
P
S
T
L
I
----
T
P
V
--
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
-------
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
---------
F
L
G
A
I
L
L
S
S
P
L
M
C
------------------
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
---------
L
S
A
---
P
F
E
---------
D
I
Y
A
G
L
W
----------
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
-----------------------
M
A
L
T
W
Q
T
H
L
-
L
A
L
A
-------
C
A
L
F
T
A
Y
L
--------
G
A
S
M
-------
S
H
V
M
A
V
V
G
L
P
S
G
T
----
W
P
F
C
L
-----
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
------
S
K
V
T
Y
P
E
E
N
R
I
F
----------
Y
L
Q
-----
S
-------------------------------------------
22
PsiBlast_CBE
99.07
79%
-153
- C3 -
4EZD
10
UT1_BOVIN
B:
[31-376]
---------------------------------------------------------------------------------
G
----------
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
--
K
P
Q
--
A
L
Q
F
V
-------
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
G
L
L
V
Q
N
P
W
C
A
L
N
G
C
V
G
T
V
V
-----
S
T
L
T
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
--------
L
M
A
I
-
Y
S
--------
D
K
G
--
N
Y
---------
F
W
W
L
L
F
------
P
V
S
---
A
M
S
M
T
-----------------
C
P
V
F
-------------
S
S
A
L
N
S
V
-
L
S
K
W
D
L
P
V
F
-------
T
L
P
F
N
M
A
L
S
----
M
-
Y
L
S
A
T
G
--
H
---------------
Y
N
--------------
P
F
F
P
S
T
L
I
----
T
P
V
--
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
-------
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
---------
F
L
G
A
I
L
L
S
S
P
L
M
C
------------------
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
---------
L
S
A
---
P
F
E
---------
D
I
Y
A
G
L
W
----------
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
-----------------------
M
A
L
T
W
Q
T
H
L
-
L
A
L
A
-------
C
A
L
F
T
A
Y
L
--------
G
A
S
M
-------
S
H
V
M
A
V
V
G
L
P
S
G
T
----
W
P
F
C
L
-----
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
------
S
K
V
T
Y
P
E
E
N
R
I
F
----------
Y
L
Q
-----
S
R
------------------------------------------
21
PsiBlast_CBE
99.05
79%
-154
- C3 -
4EZD
10
UT1_BOVIN
C:
[31-376]
---------------------------------------------------------------------------------
G
----------
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
--
K
P
Q
--
A
L
Q
F
V
-------
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
G
L
L
V
Q
N
P
W
C
A
L
N
G
C
V
G
T
V
V
-----
S
T
L
T
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
--------
L
M
A
I
-
Y
S
--------
D
K
G
--
N
Y
---------
F
W
W
L
L
F
------
P
V
S
---
A
M
S
M
T
-----------------
C
P
V
F
-------------
S
S
A
L
N
S
V
-
L
S
K
W
D
L
P
V
F
-------
T
L
P
F
N
M
A
L
S
----
M
-
Y
L
S
A
T
G
--
H
---------------
Y
N
--------------
P
F
F
P
S
T
L
I
----
T
P
V
--
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
-------
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
---------
F
L
G
A
I
L
L
S
S
P
L
M
C
------------------
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
---------
L
S
A
---
P
F
E
---------
D
I
Y
A
G
L
W
----------
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
-----------------------
M
A
L
T
W
Q
T
H
L
-
L
A
L
A
-------
C
A
L
F
T
A
Y
L
--------
G
A
S
M
-------
S
H
V
M
A
V
V
G
L
P
S
G
T
----
W
P
F
C
L
-----
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
------
S
K
V
T
Y
P
E
E
N
R
I
F
----------
Y
L
Q
-----
S
R
------------------------------------------
1
PsiBlast_PDB
99.00
79%
-154
- C3 -
4EZC
8
UT1_BOVIN
A:
[31-375]
---------------------------------------------------------------------------------
G
----------
Y
I
T
G
D
M
K
E
F
A
N
W
L
K
D
--
K
P
Q
--
A
L
Q
F
V
-------
D
W
V
L
R
G
I
S
Q
V
V
F
V
S
N
P
I
S
G
I
L
I
L
V
G
L
L
V
Q
N
P
W
C
A
L
N
G
C
V
G
T
V
V
-----
S
T
L
T
A
L
L
L
S
Q
D
R
S
A
I
T
A
G
L
Q
G
Y
N
A
T
L
V
G
I
--------
L
M
A
I
-
Y
S
--------
D
K
G
--
N
Y
---------
F
W
W
L
L
F
------
P
V
S
---
A
M
S
M
T
-----------------
C
P
V
F
-------------
S
S
A
L
N
S
V
-
L
S
K
W
D
L
P
V
F
-------
T
L
P
F
N
M
A
L
S
----
M
-
Y
L
S
A
T
G
--
H
---------------
Y
N
--------------
P
F
F
P
S
T
L
I
----
T
P
V
--
T
S
V
P
N
V
T
W
P
D
L
S
A
L
Q
L
L
K
S
-------
L
P
V
G
V
G
Q
I
Y
G
C
D
N
P
W
T
G
G
I
---------
F
L
G
A
I
L
L
S
S
P
L
M
C
------------------
L
H
A
A
I
G
S
L
L
G
I
I
A
G
L
S
---------
L
S
A
---
P
F
E
---------
D
I
Y
A
G
L
W
----------
G
F
N
S
S
L
A
C
I
A
I
G
G
T
F
-----------------------
M
A
L
T
W
Q
T
H
L
-
L
A
L
A
-------
C
A
L
F
T
A
Y
L
--------
G
A
S
M
-------
S
H
V
M
A
V
V
G
L
P
S
G
T
----
W
P
F
C
L
-----
A
T
L
L
F
L
L
L
T
T
K
N
P
N
I
Y
K
M
P
I
------
S
K
V
T
Y
P
E
E
N
R
I
F
----------
Y
L
Q
-----
S
-------------------------------------------
3
PsiBlast_PDB
75.70
34%
-148
- C3 -
3M6E
-
UT_DESVH
A:
[3-331]
--------------------------------------------------------------------------------------------------
R
A
F
G
E
Q
L
L
K
--
N
P
L
--
I
-
E
F
C
-------
D
S
V
C
R
G
C
G
Q
V
M
F
Q
N
N
T
V
T
G
L
L
F
F
A
G
I
F
Y
N
S
T
T
L
G
V
C
A
V
L
G
T
A
A
-----
S
T
L
T
A
Q
L
L
G
V
D
K
P
L
V
R
A
G
L
F
G
A
N
G
T
L
A
G
I
--------
A
L
P
F
-
F
F
--------
N
-----
Y
---------
E
P
A
M
L
G
------
Y
V
A
---
L
N
G
A
F
-----------------
T
T
I
I
-------------
M
A
S
L
L
N
F
-
L
G
K
W
G
V
P
A
L
-------
T
A
P
F
V
L
A
T
W
----
L
-
L
M
F
G
V
Y
--
K
---------------
L
S
--------------
L
F
H
P
G
A
L
I
----
A
P
A
L
P
S
V
A
---
D
M
G
T
V
T
G
R
T
F
M
E
G
-------
L
F
K
G
V
G
E
V
M
F
Q
D
N
I
V
T
G
V
I
---------
F
V
V
A
I
L
V
N
S
R
I
S
A
------------------
L
F
A
V
I
G
S
L
V
G
L
C
T
A
L
I
---------
M
H
S
---
P
E
T
---------
P
V
R
L
G
L
Y
----------
G
F
N
S
V
L
C
G
I
A
M
G
G
I
F
-----------------------
F
Y
L
N
I
R
T
F
L
-
Y
A
L
G
-------
C
M
V
L
G
A
I
A
--------
T
G
A
F
-------
S
V
L
L
S
P
I
G
M
P
A
L
T
----
W
P
F
I
V
-----
V
T
W
L
F
L
F
A
G
S
M
F
R
N
I
A
Q
V
P
T
------
E
K
A
G
T
P
E
D
N
L
R
S
----------
L
A
I
-------------------------------------------------
34
Fugue
73.78
33%
-141
- C3 -
3K3F
-
UT_DESVH
A:
[2-337]
--------------------------------------------------------------------------------------------------
G
R
A
F
G
E
Q
L
L
--
K
N
P
--
L
I
E
F
C
-------
D
S
V
C
R
G
C
G
Q
V
M
F
Q
N
N
T
V
T
G
L
L
F
F
A
G
I
F
Y
N
S
T
T
L
G
V
C
A
V
L
G
T
A
A
-----
S
T
L
T
A
Q
L
L
G
V
D
K
P
L
V
R
A
G
L
F
G
F
N
G
T
L
A
G
I
--------
A
L
P
F
-
F
F
--------
N
Y
E
--
P
A
------------
M
L
G
------
Y
V
A
---
L
N
G
A
F
-----------------
T
T
I
I
-------------
M
A
S
L
L
N
F
-
L
G
K
W
G
V
P
A
L
-------
T
A
P
F
V
L
A
T
W
----
L
-
L
M
F
G
V
Y
--
K
---------------
L
S
--------------
L
F
H
P
G
A
L
I
----
A
P
----
A
L
P
S
V
D
M
G
T
V
T
G
R
T
F
M
E
G
-------
L
F
K
G
V
G
E
V
M
F
Q
D
N
I
V
T
G
V
I
---------
F
V
V
A
I
L
V
N
S
R
I
S
A
------------------
L
F
A
V
I
G
S
L
V
G
L
C
T
A
L
I
---------
M
H
S
---
P
E
T
---------
P
V
R
L
G
L
Y
----------
G
F
N
S
V
L
C
G
I
A
M
G
G
I
F
-----------------------
F
Y
L
N
I
R
T
F
L
-
Y
A
L
G
-------
C
M
V
L
G
A
I
A
--------
T
G
A
F
-------
S
V
L
L
S
P
I
G
M
P
A
L
T
----
W
P
F
I
V
-----
V
T
W
L
F
L
F
A
G
S
M
F
R
N
I
A
Q
V
P
T
------
E
K
A
G
T
P
E
D
N
L
R
S
----------
L
A
I
-------------------------------------------------
43
Fugue
50.43
18%
-115
- C1 -
2BVL
6
TOXB_PEPDI
A:
[1-543]
MSLVN
R
K
Q
L
E
K
M
A
NVRFRTQE
D
E
Y
V
A
I
L
D
A
L
E
E
Y
H
N
MSENT
V
V
E
K
Y
L
K
L
K
D
---
I
N
S
L
T
D
I
C
I
D
T
Y
K
K
S
G
R
-
N
K
A
L
K
-
K
F
K
E
----------
Y
L
V
T
E
V
L
E
L
K
N
N
-
N
L
--
T
P
V
EK
N
L
H
F
V
W
I
GGQIN
D
T
A
I
N
Y
I
N
Q
W
K
D
V
N
S
D
-----
Y
N
V
N
V
F
Y
D
S
N
A
F
L
I
N
T
L
K
K
T
V
V
-----
E
S
A
I
N
D
T
L
E
S
F
R
E
N
L
N
D
P
R
F
D
Y
N
K
-
F
F
R
K
--------
R
M
E
I
-
I
Y
--------
D
K
Q
--
K
N
---------
F
I
N
Y
Y
K
------
A
Q
R
---
E
E
N
P
E
-----------------
L
I
I
D
-------------
D
I
V
K
T
Y
L
-
S
N
E
Y
S
K
E
I
D
-------
E
L
N
T
Y
I
E
E
S
----
L
-
N
K
I
T
Q
N
--
S
---------------
G
N
DVRNF
G
E
F
K
N
GES
F
N
L
Y
E
Q
E
L
V
----
E
R
W
--
N
L
A
A
A
S
D
I
L
R
I
S
A
L
K
E
I
G
G
-------
M
Y
L
D
V
D
M
L
P
G
I
Q
P
D
L
F
E
S
I
EKPSSVT
V
D
F
W
E
M
T
K
L
E
A
I
M
K
Y
KEYIPEYTS
E
H
F
D
M
LD
E
E
V
Q
S
S
F
E
S
V
L
A
S
K
S
D
K
S
EIFSSL
G
D
M
E
A
S
---
P
L
E
V
K
I
A
F
N
SKG
I
I
N
Q
G
L
I
----------
S
V
K
D
S
Y
C
S
N
L
I
V
K
Q
I
E
N
R
Y
K
I
L
N
N
S
L
N
P
A
I
S
EDND
F
N
T
T
T
N
T
F
I
D
S
I
-
M
A
E
A
NADN
G
R
F
M
M
E
L
G
K
Y
L
--------
R
V
G
F
FPDVK
T
T
I
N
L
S
G
P
E
A
Y
A
A
A
Y
----
Q
D
L
L
M
FKEGS
M
N
I
H
L
I
E
A
D
L
R
N
F
E
I
S
K
T
N
I
------
S
Q
S
T
E
Q
E
M
A
S
L
W
SFD
D
A
R
A
K
A
Q
F
E
E
-----
Y
K
R
N
Y
F
E
G
A
L
----------------------------------
35
Fugue
47.90
15%
-111
- C5 -
4PQG
2
?
A:
[6-511]
-------------------------------------------
H
H
H
M
T
I
Y
N
---
I
N
-
L
G
I
G
W
A
S
S
G
V
E
Y
A
Q
A
Y
R
A
G
V
F
R
K
L
N
L
S
S
K
F
I
F
TDM
I
L
A
D
N
I
Q
H
L
T
A
N
I
G
F
--
D
-----
D
N
Q
V
-------
I
W
L
Y
N
H
F
T
D
I
K
I
A
P
T
S
V
T
V
D
D
V
L
A
Y
F
G
G
E
E
S
H
R
E
K
N
G
K
V
L
R
V
F
F
FDQD
K
F
V
T
C
Y
L
V
D
E
N
K
D
L
V
Q
H
A
E
Y
V
F
K
G
N
L
I
R
K
D
Y
F
S
YTRY
C
S
E
Y
-
F
A
--------
P
K
D
N
V
A
V
---------
L
Y
Q
R
T
F
Y
N
EDGT
P
V
Y
---
D
I
L
M
N
QGKEEVYHFKD
K
I
F
Y
G
K
Q
A
F
V
-------------
R
A
F
M
K
S
L
N
L
N
K
S
D
L
V
I
L
DRETGI
G
Q
V
V
F
E
E
A
Q
T
----
A
-
H
L
A
V
V
V
--
H
A
EHYSENATNED
Y
I
L
W
N
--------------
N
Y
Y
D
Y
Q
F
T
N
ADK
V
D
F
--
F
I
V
S
T
D
R
Q
N
E
V
L
Q
E
Q
F
A
K
Y
TQHQ
P
K
I
V
T
I
P
V
G
S
I
D
S
L
T
D
S
S
Q
G
R
K
---------
P
F
S
L
I
T
A
S
R
L
A
K
E
------------------
K
H
I
D
W
L
V
K
A
V
I
E
A
H
K
E
---------
L
P
E
---
L
T
F
---------
D
I
Y
G
S
G
G
----------
E
D
S
L
L
R
E
I
I
A
N
H
Q
A
E
-----------------------
D
Y
I
Q
L
K
G
H
A
E
L
S
Q
I
-------
Y
S
Q
Y
E
V
Y
L
T
ASTSEGF
G
L
T
L
-------
M
E
A
I
G
-
S
G
L
P
L
I
G
----
F
D
V
P
Y
-----
G
N
Q
T
F
I
---
E
D
G
Q
N
G
Y
L
I
P
S
------
S
S
D
H
V
E
D
Q
I
K
Q
A
----------
Y
A
A
-----
K
I
C
Q
L
Y
Q
E
N
R
L
E
A
M
R
A
Y
S
Y
Q
I
A
E
G
F
L
T
K
E
I
L
E
K
W
K
K
T
V
E
E
V
L
HD
26
HHSearch
47.82
25%
-131
* C3 *
3K3F
-
UT_DESVH
A:
[176-320]
---------------------------------------------------------------------------------------------------------------
T
--
G
R
T
F
M
-------
E
G
L
F
K
G
V
G
E
V
M
F
Q
D
N
I
V
T
G
V
I
F
V
V
A
I
L
V
N
S
R
I
S
A
L
F
A
V
I
G
S
L
V
-----
G
L
C
T
A
L
I
M
H
S
P
E
T
P
V
R
L
G
L
Y
G
F
N
S
V
L
C
G
I
--------
A
M
G
G
I
F
F
--------
Y
L
N
--------------
I
R
T
F
L
------
Y
A
L
---
G
C
M
V
L
-----------------
G
A
I
A
-------------
T
G
A
F
S
V
L
-
L
S
P
I
G
M
P
A
L
-------
T
W
P
F
I
V
V
T
W
----
L
-
F
L
F
A
G
S
--
M
---------------
F
R
--------------
N
I
A
Q
V
P
T
E
----
K
A
G
--
T
P
E
D
N
L
R
S
L
A
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
45.47
14%
-105
- C5 -
3WDO
-
?
A:
[1-453]
---------------------DYKMT
P
G
E
R
R
A
T
W
G
L
G
T
V
F
S
L
R
M
L
G
M
F
M
V
L
P
V
L
T
T
Y
G
M
A
L
Q
G
A
S
E
A
L
I
G
I
A
I
G
I
Y
G
-
L
T
Q
A
----------
V
F
Q
I
P
F
G
L
L
S
D
R
I
G
R
--
K
P
L
--
I
V
G
G
L
-------
A
V
F
A
A
G
-
S
V
I
A
A
L
S
D
S
I
W
G
I
I
L
G
R
A
L
Q
G
S
----------
G
A
I
A
-----
A
A
V
M
A
L
L
S
D
L
T
R
E
Q
N
R
T
K
A
M
A
F
I
G
V
S
F
G
I
--------
T
F
A
I
-
A
M
--------
V
L
G
--
P
I
I
T
H
K
LG
L
H
A
L
F
W
M
I
A
------
I
L
A
---
T
T
G
I
A
-----------------
L
T
I
W
V
VPNS
S
T
H
V
L
N
R
E
S
G
M
V
K
G
S
-
F
S
K
V
L
A
E
P
R
-------
L
L
K
L
N
F
G
I
M
----
C
-
L
H
M
L
L
M
--
S
---------------
T
F
--------------
V
A
L
P
G
Q
L
A
----
D
A
G
--
F
P
A
A
E
H
W
K
V
Y
L
A
T
M
L
I
A
F
G
-------
S
V
V
P
F
I
I
Y
A
E
V
K
R
K
M
K
Q
V
F
---------
V
F
C
V
G
L
I
V
V
A
E
I
V
------------------
L
W
N
A
Q
T
Q
F
W
Q
L
V
V
G
V
Q
---------
L
F
F
---
V
A
F
---------
N
L
M
E
A
L
L
P
S
L
I
S
K
E
SPA
G
Y
K
G
T
A
M
G
V
Y
S
T
S
Q
F
-----------------------
L
G
V
A
I
G
G
S
L
-
G
G
W
I
-------
D
G
M
F
D
G
Q
G
--------
V
F
L
A
-------
G
A
M
L
A
A
V
W
L
A
V
A
S
T
MKE
P
P
Y
V
S
-----
S
L
R
I
E
I
P
A
D
I
A
A
N
E
A
L
K
V
R
L
L
E
TEGV
K
E
V
L
I
A
E
E
E
H
S
A
----------
Y
V
K
I
DSKV
T
N
R
F
E
V
E
Q
A
I
R
QAL------------------------------
42
Fugue
44.01
11%
-96
- C2 -
3SLU
-
?
A:
[8-371]
-------------------------------------------------------
G
V
Q
T
A
Y
W
V
Q
E
A
V
Q
P
G
D
S
L
A
D
V
L
-
A
R
S
G
----------
M
A
R
D
E
I
A
R
I
T
E
K
Y
R
H
LR
A
D
Q
--
S
V
H
V
L
-------
V
G
G
D
G
G
A
R
E
V
Q
F
F
T
D
E
D
G
E
R
N
L
V
A
L
E
K
K
G
G
I
W
R
R
S
A
S
E
A
D
M
K
V
-----
L
P
T
L
R
S
V
V
V
K
T
S
A
R
G
S
L
A
R
A
E
V
P
V
E
I
R
E
S
--------
L
S
G
I
-
F
A
GRFSLDGL
K
E
G
--
D
A
---------
V
R
L
I
Y
D
------
S
L
Y
F
HG
Q
Q
V
A
A
-----------------
G
D
I
L
-------------
A
A
E
V
V
K
G
-
G
T
R
H
Q
A
F
Y
Y
-------
R
S
D
K
G
---
G
----
N
-
Y
Y
D
E
D
G
--
R
---------------
V
-----------------
L
Q
G
F
N
I
----
E
P
L
--
V
Y
T
R
I
S
S
P
F
G
Y
R
M
H
P
I
L
H
T
-------
W
R
L
H
T
G
I
D
Y
A
A
P
Q
G
----------------
T
P
V
R
A
S
A
D
G
V
I
------------------
T
F
K
G
R
K
G
G
Y
G
N
A
V
M
I
R
---------
H
A
N
---
G
V
E
---------
T
L
Y
A
H
L
S
----------
A
F
S
Q
A
Q
G
N
V
R
G
G
E
--------------------------------------------------------------
V
I
G
F
-------
V
G
S
T
G
R
S
T
G
P
H
L
H
----
Y
E
A
R
I
-----
N
G
------
Q
P
V
N
P
V
S
V
A
L
P
T
------
P
E
L
T
-
Q
A
D
K
A
A
F
----------
A
A
Q
-----
K
Q
K
A
D
A
L
L
A
R
L
R--------------------------------
12
PsiBlast_PDB
44.01
22%
-122
- C4 -
4HC1
-
?
H:
[11-194]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
------
P
S
Q
---
S
L
S
L
T
-----------------
C
S
V
T
-------------
G
Y
S
I
T
S
G
-
Y
-
Y
W
N
W
-
I
R
-------
Q
F
P
G
N
K
L
E
W
----
M
G
Y
I
S
Y
D
G
SN
N
---------------
Y
N
--------------
P
S
L
K
N
R
V
S
----
I
T
R
--
D
T
S
K
N
H
F
F
L
K
L
S
S
V
T
T
E
D
T
-------
A
T
Y
Y
C
A
R
A
S
D
S
D
----
G
F
A
---------
Y
W
G
Q
--------------------------------
G
T
L
V
T
V
S
A
A
K
T
---------
T
A
P
SVY
P
L
A
---------
P
V
C
G
G
T
T
----------
G
S
S
V
T
L
G
C
L
-
V
K
G
Y
F
PEP--------------------
V
T
L
T
W
N
S
G
S
-
L
S
S
G
-------
V
H
T
F
P
A
I
L
--------
Q
S
G
L
-------
Y
T
L
S
S
S
V
T
V
T
S
N
T
----
W
P
S
Q
T
-----
I
T
C
N
V
A
H
P
A
S
S
T
K
V
D
K
K
I
E
P
------
R
V
P
-----------------------------------------------------------------------
4
PsiBlast_PDB
32.04
23%
-92
- C4 -
1MCO
-
?
H:
[11-113]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
------
P
S
E
---
A
L
S
L
T
-----------------
C
T
V
S
-------------
G
D
S
I
N
T
I
-
L
Y
Y
W
S
W
--
I
-------
R
Q
P
P
G
K
G
L
E
WIGY
I
-
Y
Y
S
G
S
T
--
Y
---------------
G
N
--------------
P
S
L
K
S
R
V
T
----
I
S
V
--
N
T
S
K
N
Q
F
Y
S
K
L
S
S
V
T
A
A
D
T
-------
A
V
Y
Y
C
A
R
V
P
L
V
V
N
P
W
G
Q
G
T
---------
L
V
T
V
S
S
A
S
T
K
G
P
S
------------------
V
F
P
L
A
P
S
S
K
S
T
S
G
G
T
A
---------
A
L
G
---
C
L
V
---------
K
D
Y
F
P
Q
P
----------
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
-----------------------
T
F
P
A
V
L
Q
S
S
-
G
L
Y
S
-------
L
S
S
V
V
T
V
P
--------
S
S
S
L
-------
G
T
Q
T
Y
I
C
N
V
N
H
K
P
----
S
N
T
K
V
-----
D
K
R
V
A
P
E
L
L
G
G
P
S
V
F
L
F
P
P
K
------
P
K
D
T
L
M
I
S
R
T
P
E
----------
V
T
C
-----
V
V
V
D
V
S
H
E
D
P
----------------------------------
6
PsiBlast_PDB
31.58
23%
-112
- C4 -
3J2Z
-
?
B:
[59-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
---------------
Y
N
--------------
Q
K
F
K
D
K
A
T
----
L
T
V
--
D
K
S
S
S
T
A
Y
M
Q
L
S
S
L
T
S
E
D
S
-------
A
------
V
Y
Y
C
A
R
G
V
T
R
G
Y
---------
F
--
D
V
W
G
T
G
T
T
V
T
------------------
V
S
S
A
K
T
T
A
P
S
V
Y
-------------------
P
L
A
---------
P
V
C
G
G
T
T
----------
G
S
S
V
T
L
G
C
L
-
V
K
G
Y
F
P
E
P
--------------------
V
T
L
T
W
N
S
G
S
-
L
S
S
G
-------
V
H
T
F
P
A
L
L
--------
Q
S
G
L
-------
Y
T
L
S
S
S
V
T
V
T
S
N
T
----
W
P
S
Q
T
-----
I
T
C
N
V
A
H
P
A
S
S
T
K
V
D
K
K
I
E
P
------
R
-------------------------------------------------------------------------
5
PsiBlast_PDB
31.43
23%
-112
- C4 -
3J2Y
-
?
B:
[59-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
---------------
Y
N
--------------
Q
K
F
K
D
K
A
T
----
L
T
V
--
D
K
S
S
S
T
A
Y
M
Q
L
S
S
L
T
S
E
D
S
-------
A
------
V
Y
Y
C
A
R
G
V
T
R
G
Y
---------
F
--
D
V
W
G
T
G
T
T
V
T
------------------
V
S
S
A
K
T
T
A
P
S
V
Y
-------------------
P
L
A
---------
P
V
C
G
G
T
T
----------
G
S
S
V
T
L
G
C
L
-
V
K
G
Y
F
P
E
P
--------------------
V
T
L
T
W
N
S
G
S
-
L
S
S
G
-------
V
H
T
F
P
A
L
L
--------
Q
S
G
L
-------
Y
T
L
S
S
S
V
T
V
T
S
N
T
----
W
P
S
Q
T
-----
I
T
C
N
V
A
H
P
A
S
S
T
K
V
D
K
K
I
E
P
------
R
-------------------------------------------------------------------------
7
PsiBlast_PDB
30.92
23%
-113
- C4 -
4GQ9
-
?
H:
[59-194]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
---------------
Y
N
--------------
Q
K
F
K
D
K
A
T
----
L
T
V
--
D
K
S
S
S
T
A
Y
M
Q
L
S
S
L
T
S
E
D
S
-------
A
------
V
Y
Y
C
A
R
G
V
T
R
G
Y
---------
F
--
D
V
W
G
T
G
T
T
V
T
------------------
V
S
S
A
K
T
T
A
P
S
V
Y
-------------------
P
L
A
---------
P
V
C
G
G
T
T
----------
G
S
S
V
T
L
G
C
L
-
V
K
G
Y
F
PEP--------------------
V
T
L
T
W
N
S
G
S
-
L
S
S
G
-------
V
H
T
F
P
A
L
L
--------
Q
S
G
L
-------
Y
T
L
S
S
S
V
T
V
T
S
N
T
----
W
P
S
Q
T
-----
I
T
C
N
V
A
H
P
A
S
S
T
K
V
D
K
K
I
E
P
------
R
-------------------------------------------------------------------------
16
PsiBlast_PDB
30.87
22%
-93
* C4 *
2G2R
1
HVM63_MOUSE
H:
[60-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
--------------
Q
K
F
K
G
K
A
T
----
L
T
V
--
D
K
S
S
N
T
A
Y
M
D
L
N
S
L
T
S
E
D
S
A------
V
Y
Y
C
V
P
Y
D
Y
A
A
D
R
-----
V
---------
Y
W
G
H
--------------------------------
G
T
L
V
T
V
S
T
A
K
T
---------
T
A
P
SVY
P
L
A
---------
P
V
C
G
G
T
T
----------
G
S
S
V
T
L
G
C
L
-
V
K
G
Y
F
PEP--------------------
V
T
L
T
W
N
S
G
S
-
L
S
S
G
-------
V
H
T
F
P
A
L
L
--------
Q
S
G
L
-------
Y
T
L
S
S
S
V
T
V
T
S
N
T
----
W
P
S
Q
T
-----
I
T
C
N
V
A
H
P
A
S
S
T
K
V
D
K
K
I
E
P
------
R
G
------------------------------------------------------------------------
17
PsiBlast_PDB
30.68
27%
-100
- C4 -
4X8J
-
?
H:
[108-191]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
L
V
T
V
S
A
A
K
T
---------
T
A
P
SVY
P
L
A
---------
P
V
C
G
G
T
T
----------
G
S
S
V
T
L
G
C
L
-
V
K
G
Y
F
PEP--------------------
V
T
L
T
W
N
S
G
S
-
L
S
S
G
-------
V
H
T
F
P
A
L
L
--------
Q
S
G
L
-------
Y
T
L
S
S
S
V
T
V
T
S
N
T
----
W
P
S
Q
T
-----
I
T
C
N
V
A
H
P
A
S
S
T
K
V
D
K
K
I
E
P
------
R
D
P
I
----------------------------------------------------------------------