@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ZNT2_HUMAN: (2015-12-12 )
MEAKEKQHLLDARPAIRSYTGSLWQEGAGWIPLPRPGLDLQAIELAAQSNHHCHAQKGPDSHCDPKKGKAQRQLYVASAICLLFMIGEVVEILGALVSVLSIWVVTGVLVYLAVERLISGDYEIDGGTMLITSGCAVAVNIIMGLTLHQSGHGHSHGTTNQQEENPSVRAAFIHVIGDFMQSMGVLVAAYILYFKPEYKYVDPICTFVFSILVLGTTLTILRDVILVLMEGTPKGVDFTAVRDLLLSVEGVEALHSLHIWALTVAQPVLSVHIAIAQNTDAQAVLKTASSRLQGKFHFHTVTIQIEDYSEDMKDCQACQGPSD
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.-----....-.-..20-------.........---30........40........50........60........70........80.....--------------------...90------------------------------------------------.........-100.......110....---------...120...----....130.--------------......140.......150....-----...160.......170--------........180--------.......190..--------.------....200......------.210--....------.....220.......230..---------------------.....240..----....--.250.......260-----.------------..-....270-------------........------.280.......--290....-...-----300.----..-....310.......320.--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEA
K
E
K
Q
H
L
LDA-----
R
P
A
I
-
R
-
S
Y
T
--------
G
S
L
W
QEGAG---WIPLPRPGL
D
L
Q
A
I
E
L
A
AQSNHHCHAQKGPDSHCDPKKG
K
A
Q
R
Q
L
Y
V
A
S
A
I
C
L
L
F
M
I
--------------------
G
E
V
V
-------------------------------------------------
E
I
L
G
A
L
V
S
V
-
L
S
I
W
V
V
T
G
V
L
V
Y
L
A
V
E
R
---------
L
ISGD
Y
E
ID----G
G
T
M
L
I
TS--------------G
C
A
V
A
V
N
I
I
M
G
L
T
L
HQSGHGHSH-----GTTNQQEENP
S
V
R
A
A
---------
F
I
H
V
I
G
D
F
M
Q
S
--------
M
G
V
L
V
A
A
Y
I
L
YF--------K------PEYKYV
D
P
I
C
T
F
V
------
F
S
----
I
L
V
L
------
G
T
T
L
T
I
L
R
D
V
I
L
V
L
MEGTPK---------------------GV
D
F
T
A
V
R
D
L
----
L
L
S
V
--
E
G
V
E
A
L
H
S
L
H
I
W
A
L
-----T------------VA-Q
P
V
L
S
---------------
V
H
I
A
I
AQN------T
D
A
Q
A
V
L
K
T
A
S
--
S
RLQ
G
K
F
-
H
F
H
-----
T
V
T
I
----
Q
I-E
D
Y
S
E
D
M
K
D
C
Q
ACQGPSD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
90.15
20%
-127
- C4 -
3H90
-
FIEF_ECOLI
A:
[2-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
A
A
I
A
A
T
A
M
A
S
L
L
L
L
--------------------
I
K
I
F
A
WWYTGSVSILA
A
L
V
D
S
L
V
D
I
G
A
S
L
T
N
L
L
V
V
R
Y
S
L
QPADDNHSFGHGK
A
E
S
L
A
A
L
A
Q
S
-
M
F
I
S
G
S
A
L
F
L
F
L
T
G
I
Q
H
---------
L
I
S
P
T
P
M
T
D
----
P
G
V
G
V
I
V
T
--------------
I
V
A
L
I
C
T
I
I
L
V
S
F
Q
R
W
V
V
--------------
R
R
T
Q
S
Q
A
V
R
A
D
---------
M
L
H
Y
Q
S
D
V
M
M
N
--------
G
A
I
L
L
A
L
G
L
S
W
Y
----------------
G
W
H
R
A
D
A
L
F
A
L
G
------
I
G
----
I
Y
I
L
------
Y
S
A
L
R
M
G
Y
E
A
V
Q
S
L
L
D
R
A
L
P
---------------------
D
E
E
R
Q
E
I
I
D
I
----
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
-----
G
------------
P
T
--
R
F
I
Q
---------------
I
H
L
E
M
E
D
S
LP
L
---
V
Q
A
H
M
V
A
D
Q
V
E
--
Q
A
I
L
R
R
F
-
P
G
S
-----
D
V
I
I
----
H
Q
-
D
P
C
S
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
Fugue
78.06
17%
-61
* C4 *
2QFI
-
FIEF_ECOLI
A:
[5-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y
G
R
L
V
S
R
A
A
I
A
A
T
AMASL
L
L
L
I
-
K
-
I
F
A
--------
W
W
Y
T
G
S
V
S
I
---
L
A
A
L
V
D
S
L
V
D
I
G
A
S
L
T
N
L
L
V
V
R
Y
--
S
L
Q
P
A
D
D
N
H
S
F
G
H
G
K
A
-----------------------------------------------------------------------------------------
E
S
L
A
A
L
A
Q
S
-
M
F
I
S
G
S
A
L
F
L
F
L
T
G
I
Q
H
---------
L
I
S
P
T
P
M
T
D
----
P
G
V
G
V
I
V
T
--------------
I
V
A
L
I
C
T
I
I
L
V
---------
S
F
Q
-----
R
W
V
V
R
R
T
Q
S
Q
A
V
R
A
D
---------
M
L
H
Y
Q
S
D
V
M
M
N
--------
G
A
I
L
L
A
--
L
G
L
S
--------
W
------
Y
G
W
H
R
A
D
A
L
F
A
L
G
------
I
G
----
I
Y
I
L
------
Y
S
A
L
R
M
G
Y
E
A
V
Q
S
L
L
D
R
A
L
P
---------------------
D
E
E
R
Q
E
I
I
D
I
----
V
T
S
W
--
P
G
V
S
G
A
H
D
L
R
T
R
Q
S
-----
G
-------------
P
-
T
R
F
I
Q
---------------
I
H
L
E
M
E
D
S
LPL---
V
Q
A
H
M
V
A
D
Q
V
E
--
Q
A
I
L
R
R
F
-
P
G
S
-----
D
V
I
I
----
H
Q
-
D
P
C
S
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
67.47
15%
-117
- C4 -
3J1Z
-
?
P:
[7-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
F
W
V
K
L
A
S
R
A
S
V
A
T
A
L
T
L
I
T
--------------------
I
K
L
L
AWLYSGSASMLASLTDSFADTLASIINFIAIRYAIVPADHDHRYGHGKA
E
P
L
A
A
L
A
Q
S
-
A
F
I
M
G
S
A
F
L
L
L
F
Y
G
G
E
R
---------
L
L
N
P
S
P
V
E
N
----
A
T
L
G
V
V
V
S
--------------
V
V
A
I
V
L
T
L
A
L
V
L
L
Q
K
R
A
L
--------------
A
A
T
N
S
T
V
V
E
A
D
---------
S
L
H
Y
K
S
D
L
F
L
N
--------
A
A
V
L
L
A
L
V
L
S
Q
Y
----------------
G
W
W
W
A
D
G
L
F
A
V
L
------
I
A
----
C
Y
I
G
------
Q
Q
A
F
D
L
G
Y
R
S
I
Q
A
L
L
D
R
E
L
D
---------------------
E
D
T
R
Q
R
I
K
L
I
----
A
K
E
D
--
P
R
V
L
G
L
H
D
L
R
T
R
Q
A
-----
G
-------------
K
-
T
V
F
I
Q
---------------
F
H
L
E
L
D
G
N
LSL---
N
E
A
H
S
I
T
D
T
T
G
--
L
R
V
K
A
A
F
-
E
D
A
-----
E
V
I
I
----
H
Q
-
D
P
V
Q
V
E
P
T
T
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
66.84
13%
-128
* C5 *
2FV2
-
RCD1_HUMAN
A:
[2-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
-
Y
-
Q
W
I
--------
N
E
L
------------
S
S
P
E
T
R
E
N
A
L
L
E
L
S
K
K
R
E
S
V
---------------
P
D
L
A
P
M
L
W
H
-
S
F
G
T
I
A
A
L
L
--------------------
Q
E
I
V
-------------------------------------------------
N
I
Y
P
S
I
N
P
P
T
L
T
A
H
Q
S
N
R
V
C
N
A
L
A
L
L
Q
---------
C
V
A
S
H
P
E
T
------
R
S
A
F
L
A
A
--------------
H
I
P
L
F
L
Y
P
F
L
H
------------------
T
V
S
K
T
R
P
F
E
Y
L
R
L
T
---------
S
L
G
V
I
G
A
L
V
K
T
--------
D
E
Q
E
V
I
N
F
L
L
T
T
--------
E
--------------
I
I
P
L
C
------
L
R
----
I
M
E
S
------
G
S
E
L
S
K
T
V
A
T
F
I
L
Q
K
I
L
L
D
D
---------------------
T
G
L
A
Y
I
C
Q
T
Y
----
E
R
F
S
--
H
V
A
M
I
L
G
K
M
V
L
Q
L
S
K
E
PS
A
R
------------
L
L
-
K
H
V
V
R
---------------
C
Y
L
R
L
S
D
N
------
P
R
A
R
E
A
L
R
Q
C
-----
L
P
D
Q
L
-
K
D
T
-----
T
F
A
Q
----
V
L
K
D
D
T
T
T
K
R
W
L
A
Q
L
V
K
N
L
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
65.93
13%
-87
- C3 -
3AV4
-
DNMT1_MOUSE
A:
[67-1322]
PKCPECGQHLDDPN
L
K
Y
Q
Q
H
P
EDAVD
E
P
Q
M
L
T
SEKLSYED
S
P
M
H
R
F
T
S
F
S
V
Y
C
SRGHLCPVDTGLIEKN
V
E
L
Y
F
S
G
C
A
K
A
IHDENPSMEG
G
I
N
G
K
NLGPIN
Q
W
W
L
S
GFDGGEKV
L
I
G
F
S
T
AFA
E
Y
I
L
M
E
PSKEY
E
P
I
F
G
L
M
Q
E
K
I
Y
I
S
K
I
V
V
E
F
L
Q
N
N
PDAV
Y
E
D
L
I
N
K
I
E
T
T
V
P
P
STINVNRFT
E
D
S
L
L
R
H
A
Q
F
V
V
S
Q
V
E
S
Y
D
E
A
KDDDETPIFLS
P
C
M
R
A
L
I
H
L
A
GVSLGQ
R
R
A
T
RAPTKATTT
K
L
V
Y
Q
I
F
D
T
F
F
S
E
QIEKRRRCGVCEVCQQPACLKRRC
P
N
L
A
V
K
E
A
D
D
D
E
EADDEMPS
P
K
K
L
HQ
G
K
K
K
K
Q
N
KD
R
I
S
W
L
G
QPMKIER
T
Y
Y
Q
K
V
S
I
DE
E
M
L
E
VG
D
C
V
S
V
I
P
DDSSK
P
L
Y
L
A
R
VT
A
L
W
E
D
KNG
Q
M
M
F
H
A
H
W
F
C
A
GTDTVLGATSDPL
E
L
F
L
V
G
E
C
E
N
M
Q
LSYIH
S
K
V
K
V
I
Y
KAPSENWAMEGGK
T
Y
F
F
Q
LWYNQEYARFESPPK
T
Q
P
T
EDNKHKFC
L
S
C
I
R
L
A
E
L
R
Q
K
E
MPKVLEQIEEVDG
R
V
Y
C
SSITKNG
V
V
Y
R
L
G
D
S
V
Y
L
P
PEAFTFNIKVK
K
D
P
V
NETLYPEHYRKYSL
D
A
P
E
P
Y
R
I
G
R
I
KEI
H
C
G
K
K
KGKVNEAD
I
K
L
R
L
Y
K
F
Y
R
PENTHR
S
Y
N
G
S
Y
HTDIN
M
L
Y
W
S
D
E
E
A
V
V
N
F
S
D
V
Q
G
R
C
T
V
E
Y
-----
G
E
D
L
-
L
-
E
S
I
--------
Q
D
Y
S
Q
G
G
P
D
---
R
F
Y
F
L
E
A
Y
N
S
K
T
K
N
F
E
D
P
P
N
H
A
R
S
K
L
P
K
L
R
T
L
D
V
F
S
G
C
G
G
L
S
E
G
F
H
Q
A
G
I
S
E
T
L
W
A
I
--------------------
E
M
W
D
-------------------------------------------------
P
A
A
Q
A
F
R
L
N
-
N
P
G
T
T
V
F
T
E
D
C
N
V
L
L
K
L
---------
V
M
A
G
E
V
T
N
S
----
L
G
Q
R
L
P
Q
K
--------------
G
---
D
V
E
M
L
C
G
G
P
---
P
C
Q
G
F
S
G
-----
M
N
R
F
N
S
R
T
Y
S
K
F
K
N
--------------------
S
--------
L
V
V
S
F
L
S
Y
C
D
Y
Y
--------
R
------
P
R
F
F
L
L
E
N
V
R
N
F
V
SYRRS
M
V
L
----
K
L
T
L
------
R
C
L
V
R
M
G
Y
Q
C
T
F
G
V
L
Q
A
G
Q
Y
---------------------
G
V
A
Q
T
R
R
R
A
I
----
I
L
A
A
--
A
P
G
E
K
L
P
L
F
P
E
P
L
H
-----
V
------------
F
A
-
P
R
A
C
Q
---------------
L
S
V
V
V
D
D
K
------
K
F
------
V
S
N
--
I
T
R
L
S
S
G
-
P
F
R
-----
T
I
T
------
V
-
R
D
T
M
S
D
L
P
E
I
Q
N
G
A
S
N
S
E
IPYNGEPLS
W
F
Q
R
Q
L
R
GS
H
Y
Q
P
I
LRDHICKDMS
P
L
V
A
A
R
M
R
H
IPLFPGSDWRDLPNIQVRLGDG
V
I
A
H
K
L
Q
Y
T
F
HDVKNGYSSTGALRGVCSCAEGKACDPESRQFSTLIP
W
C
L
P
H
T
GNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVS
V
R
E
C
A
R
S
Q
GFPDS
Y
R
F
F
G
N
I
L
D
R
H
R
Q
V
G
N
AVP
P
P
L
A
K
A
I
G
L
E
I
K
L
C
L
L
S
S
A
R
E
S
A
S
A
A
V
K
A
20
Fugue
64.97
15%
-90
- C5 -
4D10
-
CSN2_HUMAN
B:
[34-447]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VD
L
E
N
Q
Y
Y
N
S
K
A
L
K
EDDPKA
A
L
S
S
F
Q
K
V
L
E
LEGEKG
E
W
G
F
K
A
L
K
Q
M
I
K
I
N
F
K
L
TNF
P
E
M
M
N
R
Y
K
Q
L
L
T
Y
I
-----
R
S
A
V
T
R
-
N
Y
S
--------
E
K
S
I
N
S
I
L
D
---
Y
I
S
T
S
K
Q
M
D
L
L
Q
E
F
Y
E
T
T
L
E
A
----
L
K
D
A
K
N
D
R
L
W
F
K
T
N
T
K
L
G
K
L
Y
L
E
R
E
--
E
Y
G
K
L
--------------------
Q
K
I
L
-------------------------------------------------
R
Q
L
H
Q
S
C
Q
T
-
Q
L
L
E
I
Y
A
L
E
I
Q
M
Y
T
A
Q
K
---------
N
N
K
K
L
K
A
L
Y
----
E
Q
S
L
H
I
K
S
----------------
A
I
P
H
P
L
I
M
G
V
I
R
E
C
G
G
K
M
H
L
R
-----
E
-----
G
E
F
E
K
A
H
T
D
---------
F
F
E
A
F
K
N
Y
D
E
S
GSPR
R
T
T
C
L
K
Y
L
V
L
A
N
M
L
M
---------
K
------
S
G
I
N
P
F
D
S
Q
E
A
K
P
------
Y
K
NDPE
I
L
A
M
------
T
N
L
V
S
A
Y
Q
N
N
D
I
T
E
F
E
K
I
L
K
---------------------
T
N
H
S
N
I
M
D
D
P
----
F
I
R
E
--
H
I
E
E
L
L
R
N
I
R
T
Q
V
L
-----
I
------------
K
L
I
K
P
Y
T
R
---------------
I
H
I
P
F
I
S
K
E
L
NID
V
A
D
V
E
S
L
L
V
Q
C
I
L
D
N
T
I
H
G
R
I
-
D
Q
V
-----
N
Q
L
L
----
E
L
-
D
H
Q
K
R
G
G
A
R
Y
T
A
L
D
K
W
T
N
Q
L
N
S
L
N
Q
A
V
V
S
K
L
A------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
62.43
13%
-90
- C2 -
4FLN
1
DEGP2_ARATH
A:
[42-509]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
A
S
F
L
N
A
V
V
K
V
-----
Y
C
T
H
-
T
-
A
P
D
YSLPWQK
Q
R
Q
F
T
S
T
G
S
A
---
F
M
I
---
G
D
G
K
L
L
T
N
A
H
C
V
E
H
D
T
Q
V
K
V
K
R
----
R
G
D
D
R
K
Y
V
A
K
V
L
V
R
G
V
D
C
D
I
A
L
L
S
V
E
S
EDFWKG
A
E
P
L
R
L
G
H
LPRL
Q
D
S
V
-------------------------------------------------
T
V
V
G
Y
P
L
G
G
-
D
T
I
S
V
T
K
G
V
V
S
R
I
E
V
T
S
Y
AHG
S
S
D
L
L
G
I
Q
I
D
A
A
I
N
PGNS
G
G
P
A
F
N
D
Q
GECI
G
V
A
F
Q
V
YEN
I
G
Y
V
I
P
T
T
V
V
S
H
F
L
T
D
Y
E
R
N
G
K
Y
T
GYPCL
G
V
L
L
Q
K
L
E
N
P
A
L
R
E
C
L
KVPTN
E
G
V
L
V
R
R
V
E
P
T
S
D
A
--------
S
K
V
L
K
E
G
D
V
I
V
S
FDD
L
H
V
G
C
E
------
G
T
V
P
F
R
S
S
E
-
R
I
A
------
F
R
----
Y
L
I
S
Q
KFAG
D
I
A
E
I
G
I
I
R
A
G
E
H
K
K
V
Q
V
V
L
R
P
RVHLVPYHIDG
G
Q
P
S
Y
I
I
VA
G
L
V
F
T
P
L
S
E
P
----
L
I
E
E
--
E
C
E
D
T
I
G
L
K
L
L
T
K
A
-----
R
YSVARFRGEQIV
I
L
-
S
Q
V
L
A
NEVNIGYEDMNN
Q
Q
V
L
K
F
N
G
I
P
I
------
R
N
I
H
H
L
A
H
L
I
D
--
M
C
K
D
K
Y
L
-
V
F
E
F
EDNY
V
A
V
L
----
E
R
-
E
A
S
N
S
A
S
L
C
I
L
K
D
Y
G
I
P
S
ERSADLLEPYVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
53.24
15%
-116
- C4 -
2ZZT
-
?
A:
[4-87]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
R
T
E
-------------------
L
D
M
Y
D
D
I
F
A
V
----
L
E
R
F
--
P
N
V
H
N
P
H
R
V
R
I
R
R
V
-----
G
------------
T
---
Y
F
I
E
---------------
M
D
I
E
V
D
G
K
MS
V
---
K
D
A
H
E
L
T
V
K
I
R
--
K
E
M
L
K
R
R
D
D
I
E
-----
D
V
T
I
----
H
V
-
E
P
L
G
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
52.18
12%
-127
- C4 -
3W61
-
?
A:
[3-82]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
---------------------
E
A
V
Q
N
R
I
V
E
A
----
A
E
R
V
--
P
G
V
R
G
V
I
H
L
R
A
R
Y
V
-----
G
------------
Q
--
D
I
W
A
D
---------------
M
I
I
G
V
D
P
E
NT
V
---
E
Q
A
H
E
I
C
E
A
V
Q
--
A
A
V
C
G
K
I
R
R
I
E
-----
S
L
A
V
----
S
A
-
E
A
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
51.45
18%
-99
- C4 -
3BYP
-
?
A:
[6-87]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
P
---------------------
P
E
E
V
E
R
I
R
A
F
----
L
Q
E
R
I
R
G
R
A
L
E
V
H
D
L
K
T
R
R
A
-----
G
------------
P
R
--
S
F
L
E
---------------
F
H
L
V
V
R
G
D
TP
V
---
E
E
A
H
R
L
C
D
E
L
E
--
R
A
L
A
Q
A
F
-
P
G
L
-----
Q
A
T
I
----
H
V
-
E
P
E
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
45.12
23%
-41
- C4 -
3BDL
-
?
A:
[279-405]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
E
S
M
D
K
A
G
N
F
I
------
G
W
----
L
H
I
D
------
G
A
N
L
S
V
L
------
L
V
E
H
A
L
S
---------------------
K
V
H
F
T
A
E
R
S
S
Y
Y
K
S
L
L
S
A
--
E
E
A
A
K
Q
K
K
E
K
V
W
A
-------------------------------------------
M
P
V
L
E
E
K
------
E
R
S
A
S
Y
K
P
V
F
V
--
T
E
I
T
D
D
L
-
H
F
Y
-----
V
Q
D
V
ET
G
T
Q
L
-
E
K
L
M
E
N
M
R
N
D
I
A
S
H
P
P
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
40.14
30%
81
- C6 -
3OG6
2
INLR1_HUMAN
B:
[135-193]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
-
L
-
K
Y
E
--------
V
A
F
W
K
E
G
A
G
N
K
T
L
F
P
V
T
P
H
G
Q
P
V
Q
I
T
L
Q
P
A
A
S
E
H
H
C
L
S
A
R
T
I
Y
T
F
S
V
P
K
Y
S
K
F
S
K
P
T
C
F
L
L
E
V
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
39.07
30%
83
- C6 -
3OG4
1
INLR1_HUMAN
B:
[135-193]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
D
-
L
-
K
Y
E
--------
V
A
F
W
K
E
G
A
G
N
K
T
L
F
P
V
T
P
H
G
Q
P
V
Q
I
T
L
Q
P
A
--
E
H
H
C
L
S
A
R
T
I
Y
T
F
S
V
P
K
Y
S
K
F
S
K
P
T
C
F
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
37.99
18%
-75
- C4 -
3H90
-
FIEF_ECOLI
A:
[27-104]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
S
V
S
I
L
A
A
---------
L
V
D
S
L
V
D
I
G
A
S
--------
L
T
N
L
L
V
V
R
Y
S
L
Q
--------
P
ADDNHS
F
G
H
G
K
A
E
S
L
A
A
L
A
------
Q
S
----
M
F
I
S
------
G
S
A
L
F
L
F
L
T
G
I
Q
H
L
I
S
P
T
P
M
---------------------
T
D
P
G
V
G
V
I
V
T
----
I
V
A
L
--
I
C
T
I
I
L
V
S
F
Q
R
W
V
V
-----
R
------------
R
T
-
Q
S
Q
A
V
---------------
R
A
D
M
L
H
Y
Q
------
S
D
V
M
M
N
G
A
I
L
L
--
A
L
G
L
S
W
Y
-
G
W
H
-----
R
A
D
A
----
L
F
-
A
L
G
I
G
I
Y
I
L
Y
S
A
L
R
M
G
Y
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
37.67
15%
-80
- C4 -
3J1Z
-
?
P:
[36-112]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
A
S
M
L
A
S
---------
L
T
D
S
F
A
D
T
L
A
S
--------
I
I
N
F
I
A
I
R
Y
A
I
V
--------
P
ADHDHR
Y
G
H
G
K
A
E
P
L
A
A
L
A
------
Q
S
----
A
F
I
M
------
G
S
A
F
L
L
L
F
Y
G
G
E
R
L
L
N
P
S
P
V
---------------------
E
N
A
T
L
G
V
V
V
S
----
V
V
A
I
--
V
L
T
L
A
L
V
L
L
Q
K
R
A
L
-----
A
------------
A
T
-
N
S
T
V
V
---------------
E
A
D
S
L
H
Y
K
------
S
D
L
F
L
N
A
A
V
L
L
--
A
L
V
L
S
Q
Y
-
G
W
W
-----
W
A
D
G
----
L
F
-
A
V
L
I
A
C
Y
I
G
Q
Q
A
F
D
L
G
Y
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
32.12
13%
44
* C6 *
2L92
-
?
A:
[71-114]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
T
-----
V
P
K
Y
-
R
D
P
A
T
--------
G
K
T
W
S
G
R
G
R
---
Q
P
A
W
L
G
N
D
P
A
A
F
L
I
Q
P
D
L
P
A
I
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
29.95
14%
217
- C4 -
1QLO
-
ICP47_HHV11
A:
[1-34]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
W
A
L
E
M
A
D
T
F
L
D
N
M
R
V
G
P
R
T
Y
A
D
V
R
D
E
I
N
K
R
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
26.45
20%
66
- C4 -
2KGS
-
ARFA_MYCTU
A:
[92-128]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
I
G
D
F
P
D
---------------------
E
A
A
K
A
A
L
M
T
A
----
L
N
G
L
LA
P
G
V
N
V
I
D
Q
I
H
V
D
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
24.95
25%
125
- C4 -
2LX0
-
?
A:
[7-26]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
A
G
L
V
A
L
-
L
T
F
L
A
F
G
F
W
L
F
K
Y
L
Q
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
Fugue
24.17
28%
600
- C1 -
1D7Q
-
?
B:
[1-14]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
G
S
H
H
H
H
H
-----
H
T
D
P
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------