@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T0814: (2014-06-11 )
MKMRVYSLLFMMLFALSIGANAQVKFFTDVNSKQIKTLQVKVAGELISEPYIALGGEEQIEINFDGLGSGYTRYAYNVVHCNADWTQSQLSPIEYMNGFQGTTIDDFANSIGTTTQYSNYRLLLPNDDVQFKVSGNYAIQVYNEDTPDQIIFTACFSVVEPVVNISASVSGNTDIDTNQSHQQVSFNINNKNFPITYPQTDLKIFVYQDNRRDNAVTDLQPMSILENQISYTYNRNLIFPAGNEYRRMEFLSNKYNGMHVENISFHNPYYNVELMTDYRRDKGTYQYDQDQDGRFFIRCSDCNDPDTEADYYIVHFTLACDPLPDGSVYLNGELFNNVLDEKSKMGYNFETKQYEKAVLLKQGSYNYQYLFVPTGSSVGQTGPIEGNYYQTQNEYSIYVYYRPMGARYDRLIGVTTVRNEMQVF
Atome Classification :
(20 SA)
.........10........20........30....----..-----..40........50.......-.-60........70.......-.80.-.......90........-------100.......110...-....120.-....-..130.......140----........150.......160----........170.......180.......190.......200........210.......220.......230.......240.......250........260.......270....-...280.......290.......300.....-..310.....-..-320-.-.-.....330.---.---.---.....340----...-.-..--.--.---.350----........-.-------360.-.-..--...370.......380........390.....-------..400-.......410...-....420..----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
M
R
V
Y
S
L
L
F
M
M
L
F
A
L
SIGAN
A
Q
V
K
F
F
TDVNS
K
Q
I
----
K
T
-----
L
Q
V
K
V
A
G
E
L
ISEP
Y
I
ALGGE
E
-
Q
-
I
E
I
N
FDGLGSG
Y
T
R
Y
A
Y
N
V
-
V
HCN-ADWTQSQL
S
P
I
E
Y
MNGF-------QGT
T
I
D
D
F
A
N
SIGTTT-QYS
N
Y
R
L
L-LPND-
D
V
Q
F
K
VSG
N
Y
A
I
Q
V
-----YNEDTP
D
Q
I
I
F
T
A
C
F
S
V
V
E
P
-----
V
V
N
I
S
A
SVSGNTDIDTNQS
H
Q
Q
V
S
F
N
INNKNF
P
I
TYPQT-
D
L
K
I
F
V
Y
QDNRRDNAVTDL
Q
P
M
S
I
L
E
N
Q
I
S
Y
T
YNR
N
L
IFPAGN
E
Y
R
R
M
E
F
L
-SNKYN
G
M
H
V
E
N
I
SFHNP
Y
Y
N
V
E
L
M
T
-DYRRDKGTYQYDQDQD
G
R
F
F
I
R
CSDCNDPDT-EA
D
Y
Y
I
V
H
F
T
-
L
A-CDP-L-P-DG
S
V
Y
L-
N
G
---
E
---
L
---
F
N
N
V
L
D
------
E
K
S
-K-MG--Y--N---F
E
------
T
K
Q
Y
E
K
A
V
-
L
-------
L
KQG-S-Y
N
--
Y
Q
Y
L
F
V
PTGSSVGQ-TGPIEG
N
Y
Y
Q
T
QN
E
Y
S
I
-------
Y
V
Y
Y
R-PMGAR
Y
D
R
L
I
G
V
T
-
T
VRNEMQVF----
11
Fugue
74.81
12%
-34
- C2 -
3PV2
-
?
A:
[6-439]
M
P
S
M
A
P
V
L
K
N
I
M
P
A
I
V
N
V
A
V
Q
G
Y
L
P
N
-
R
K
F
E
S
I
G
S
----
G
V
-----
I
I
D
P
N
N
G
V
I
I
T
N
D
H
V
I
-
R
N
A
S
-
L
-
I
T
V
T
---
L
Q
D
G
R
R
L
K
A
R
L
I
----
G
-
G
D
-
S
E
T
D
L
A
V
L
K
I
----------------------------
D
A
K
N
L
K
S
L
-
V
I
G
D
-
S
D
K
L
E
V
-
G
D
F
V
V
A
I
-----
G
N
P
F
G
L
S
Q
S
A
T
F
G
I
V
S
A
L
K
N
-----
F
I
Q
T
D
A
A
I
N
-------
P
G
N
S
G
G
A
L
V
N
A
K
G
E
L
I
G
I
N
T
A
I
L
-
V
G
I
G
F
A
I
P
I
N
M
V
K
D
V
A
Q
Q
I
I
K
F
G
S
I
H
R
G
L
M
G
I
F
V
Q
H
L
----
T
P
E
L
A
Q
A
M
G
Y
-
P
E
D
F
Q
G
A
L
V
S
Q
V
N
P
N
S
P
A
E
L
A
G
L
K
A
G
D
I
I
T
Q
I
N
D
T
K
I
T
Q
A
T
Q
V
K
T
T
I
S
------
L
L
R
-
V
G
S
T
V
K
I
I
V
E
-
R
D
-
N
K
P
-
L
-
T
-
L
S
A
V
V
T
-
D
I
---
K
---
S
---
H
E
Q
K
L
Q
------
S
N
N
-
P
-
F
L
--
Y
--
G
---
L
A
------
L
R
A
F
E
Q
E
S
-
P
-------
P
H
G
N
-
V
-
I
G
--
V
Q
V
V
G
A
S
E
N
S
A
G
W
R
-
A
G
I
R
P
G
D
I
I
I
S
A
N
K
K
P
V
TD-----
V
K
S
L
Q
-
T
I
A
Q
E
K
K
K
E
L
L
V
Q
-
V
L
R
G
P
G
S
M
Y
L
L
V
I
12
Fugue
71.53
17%
-49
- C2 -
1DMU
1
T2B1_BACIU
A:
[1-299]
-----
M
Y
N
L
H
R
E
K
I
F
M
S
Y
N
Q
N
K
Q
Y
L
E
D
N
P
E
I
Q
E
K
I
----
E
L
-----
Y
G
L
N
L
L
N
E
V
I
S
D
N
E
E
E
I
R
A
D
Y
-
N
-
E
A
N
F
L
H
P
F
W
M
N
Y
P
P
L
D
R
G
----------
K
M
P
K
G
D
Q
I
P
W
I
E
V
G
-------
E
K
A
V
G
S
K
L
T
R
L
V
S
Q
R
E
-
D
I
T
V
R
E
I
G
-
L
P
T
G
P
D
E
R
Y
L
L
T
S
P
T
I
Y
S
L
-----
T
N
G
F
T
D
S
I
M
M
F
V
D
I
K
S
V
G
P
R
-----
D
S
D
Y
D
L
V
L
S
P
N
Q
-
V
S
G
N
G
D
W
A
Q
L
E
G
G
I
Q
N
N
Q
Q
T
I
Q
G
P
R
S
--
S
Q
I
F
L
----------
P
T
I
P
P
L
Y
I
L
S
D
-------------------------
G
T
I
A
P
V
V
H
L
----
F
I
K
P
I
Y
A
M
R
S
L
T
-
K
---------------------------
G
D
T
-
G
Q
S
L
Y
K
I
K
L
A
-
S
V
-------
P
-
N
G
L
G
L
F
-
C
N
---
P
--------------------------
G
--
Y
--
A
---
F
-----------------------------
D
-
S
A
--
Y
K
F
L
F
R
P
G
K
D
-----------
D
R
T
K
S
L
L
Q
K
R
V
-------
R
V
D
L
R
-
V
L
D
K
-----
I
G
P
R
-
V
M
T
I
D
M
D
K
-----
8
Fugue
69.02
12%
-38
- C3 -
1KK1
1
IF2G_PYRAB
A:
[6-410]
--
S
R
Q
A
E
V
N
I
G
M
V
G
H
V
D
H
G
K
T
T
L
T
K
A
L
T
G
V
W
T
D
S
E
----
E
L
RRGIT
I
K
I
G
F
A
D
A
E
I
R
R
C
P
N
C
G
R
Y
S
T
-
S
-
P
V
C
P
Y
C
G
H
E
T
E
F
V
R
R
V
S
F
I
D
A
P
G
H
-
E
A
L
M
T
T
M
L
A
G
A
S
L
M
D
G
A
I
L
V
I
A
AN
E
P
C
P
R
P
Q
T
R
E
H
L
M
A
L
Q
-
I
I
G
Q
K
N
I
I
-
I
A
Q
N
-
K
I
E
L
-
V
D
K
E
K
A
L
E
N
-----
Y
R
Q
I
K
E
F
I
E
G
T
V
A
E
N
A
---
P
-----
I
I
P
I
S
A
L
H
G
A
N
I
D
V
L
V
K
A
I
E
D
F
I
P
T
P
K
R
D
P
N
-----
K
P
P
-
K
M
L
V
L
R
S
F
D
V
N
K
P
G
K
L
V
G
G
V
L
D
G
S
I
V
Q
G
-
K
L
K
V
G
D
E
I
E
I
R
P
G
V
P
Y
E
E
H
G
R
I
-
K
Y
E
P
I
T
T
E
I
V
S
L
Q
A
------------------
G
G
Q
F
V
E
E
A
Y
P
G
G
L
V
G
V
G
T
K
L
D
P
Y
L
T
-
K
G
D
L
M
A
G
N
V
V
-
G
K
-
P
G
K
-
L
-
P
-
P
--
V
W
D
-
S
L
---
R
---
L
---
E
V
H
L
L
E
------
R
V
V
-
E
-
Q
E
--
L
--
K
---
V
E
------
P
----------------
I
K
R
K
-
E
-----
V
L
L
L
N
V
G
T
A
R
T
M
G
L
-
V
T
G
L
G
K
D
E
I
E
V
K
L
Q
I
P
V
C
A
E
PG
D
R
V
A
I
S
R
-
Q
I
G
S
R
W
-
R
L
I
G
Y
G
-
I
I
K
E
---------
3
Fugue
68.02
20%
-13
- C2 -
2W0C
-
SPIKE_BPPM2
L:
[1-335]
-----------
M
I
V
K
K
K
L
A
A
G
E
F
A
E
T
F
K
N
G
N
N
I
T
I
-------------
I
K
A
V
G
E
L
V
L
R
A
Y
G
A
D
G
G
E
G
-
L
-
R
T
I
V
R
Q
G
V
S
I
K
G
M
N
Y
T
S
V
M
-
L
H
T
E
Y
A
Q
E
I
E
Y
W
V
G
D
L
D
Y
S
F
Q
--------
E
Q
T
T
K
S
R
D
V
N
S
F
Q
I
P
L
-
R
-
D
G
V
R
E
L
-
L
P
E
D
-
A
S
R
N
R
A
S
I
K
S
P
V
D
I
-----
W
I
G
G
E
N
M
T
A
L
-------------------
N
G
I
V
D
G
G
R
K
F
E
A
G
Q
E
F
Q
I
N
T
F
G
------
S
V
N
Y
W
V
S
-
D
E
E
I
R
V
F
K
E
Y
S
A
R
A
---------------
K
Y
A
Q
N
E
G
----------
R
T
A
L
E
-
A
N
N
V
------------
P
F
F
D
I
D
V
P
P
-
E
L
D
G
V
P
F
S
L
K
A
R
V
R
H
K
S
K
G
V
D
G
L
G
D
Y
T
S
I
S
V
-
K
P
A
F
Y
I
T
E
G
D
-
E
T
-
T
D
T
-
L
-
I
-
K
Y
T
S
Y
G
-------------------
S
------
T
G
S
-
H
-
S
G
--
Y
--
D
---
F
D
------
D
N
T
L
D
V
M
V
-
T
-------
L
S
A
G
----
V
--
H
R
V
F
P
V
E
T
E
L
D
Y
D
A
-
V
Q
E
V
Q
H
D
W
Y
D
E
S
F
T
T
F
I
-------
E
V
Y
S
D
-------
D
P
L
L
T
V
K
G
Y
A
Q
I
L
M
E
R
T
----
9
Fugue
67.06
19%
-19
- C1 -
4FDW
-
?
A:
[21-401]
--
A
S
L
E
D
F
S
I
E
Q
L
P
A
K
T
I
Y
A
L
G
E
N
I
D
L
T
G
L
N
V
T
G
K
Y
DDG
K
Q
-----
R
P
V
K
V
T
S
E
Q
I
S
G
F
S
S
S
V
P
V
D
K
-
Q
E
V
T
I
T
I
E
G
----------------
K
-
Q
K
S
F
S
V
H
I
S
P
V
R
V
E
N
G
V
-------
L
T
E
I
L
K
G
Y
N
E
I
I
L
P
N
S
-
V
K
S
I
P
K
D
A
-
F
R
N
S
-
Q
I
A
-
K
V
V
L
N
E
G
L
K
S
I
G
D
MA
F
F
N
S
T
V
Q
E
I
V
F
P
S
T
L
E
Q
L
K
E
DIFYY
C
Y
N
L
K
K
A
D
L
S
K
T
K
I
T
K
L
P
A
S
T
F
V
Y
A
G
I
E
E
V
L
L
P
V
T
L
K
E
I
-
G
S
Q
A
F
L
K
--------
T
S
Q
L
K
T
I
E
I
P
E
N
V
--
S
T
I
G
Q
E
A
F
R
E
S
G
I
T
T
V
K
L
P
-------
N
G
--
V
T
N
I
A
S
R
A
F
Y
Y
C
P
E
L
--------
A
E
V
T
T
Y
G
S
T
F
N
----------
D
D
P
E
A
M
I
H
P
Y
C
L
E
G
C
P
K
L
A
-
R
F
E
-
I
-
P
-
E
S
I
R
I
L
G
Q
G
---
L
---
L
---
G
G
N
R
K
V
------
T
Q
L
-
T
-
I
---------------------
P
A
N
V
T
-
Q
-------
I
N
F
S
-
A
-
F
N
--
N
T
G
I
K
E
V
K
V
E
G
T
T
P
-
P
Q
V
F
E
K
V
W
Y
G
F
P
D
D
I
T
V
-------
I
R
V
P
A
-
E
S
V
E
K
Y
K
N
A
N
G
W
R
-
D
F
T
N
K
I
T
T
F
----
16
HHSearch
50.14
27%
-52
- C2 -
4AEE
-
?
A:
[18-73]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
V
K
F
T
-
R
H
-
W
P
Q
---
Y
-
A
K
N
I
Y
L
-
I
G
---
E
---
F
---
T
S
L
Y
P
G
-------
F
V
-
K
-
L
R
--
K
--
I
-----------
E
E
Q
G
I
V
Y
L
-
K
-------
L
W
P
G
-
E
-
Y
G
--
Y
G
F
Q
I
-------------------------------------------------------------------
27
HHSearch
50.01
16%
-48
- C2 -
1QHO
1
AMYM_GEOSE
A:
[579-659]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
Q
T
S
V
V
F
T
-
V
K
S
A
P
P
-
T
N
L
-
G
D
K
I
Y
L
-
T
G
---
N
IPE
L
---
G
N
W
S
T
D
TSGAVN
N
A
Q
G
P
-
L
L
--
A
--
P
----
N
------
Y
P
D
W
F
Y
V
F
-
S
-------
V
P
A
G
-
K
T
I
Q
--
F
K
F
F
I
K
R
A
D
G
T
-------------------------------------------------------------
26
HHSearch
48.19
19%
-46
- C2 -
2VN4
4
?
A:
[496-569]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
A
V
T
F
H
-
E
L
-
V
S
T
-
Q
-
F
-
G
Q
T
V
K
V
-
A
G
---
N
AAA
L
---
G
N
W
S
T
S
------
A
A
V
-
A
-
L
D
--
A
--
V
NYA
D
N
------
H
P
L
W
I
G
T
V
-
N
-------
L
E
A
G
D
V
-
V
E
--
Y
K
Y
I
N
V
G
Q
D
G
S
-------------------------------------------------------------
25
HHSearch
47.89
17%
-23
- C2 -
4JCM
-
?
A:
[599-675]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
Q
E
S
V
R
F
V
-
V
D
-
N
A
H
-
T
-
N
Y
G
E
N
V
Y
L
-
V
G
NVP
E
---
L
---
G
N
W
N
P
A
------
D
A
I
-
G
P
M
F
--
N
QV
V
---
Y
S
------
Y
P
T
W
Y
Y
D
V
-
S
-------
V
P
A
D
T
A
-
L
E
--
F
K
F
I
I
V
D
G
N
G
N
-------------------------------------------------------------
20
HHSearch
46.83
21%
-47
- C2 -
4AEF
-
?
A:
[14-70]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
V
A
E
V
E
F
S
-
L
I
-
R
E
------
G
S
Y
A
Y
L
-
L
G
---
D
---
F
---
N
A
F
N
E
G
-------
S
F
-
R
-
M
E
--
Q
-------
E
------
G
K
N
W
K
I
K
I
-
A
-------
L
P
E
G
-
V
-
W
H
--
Y
A
F
S
I
-------------------------------------------------------------------
31
HHSearch
46.46
15%
-42
- C2 -
3BMV
2
CDGT_THETU
A:
[581-655]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
Q
I
C
V
R
F
V
-
V
N
-
N
A
S
-
T
V
Y
-
G
E
N
V
Y
L
-
T
G
---
N
---
V
AEL
G
N
W
D
T
S
------
K
A
I
G
P
-
M
F
--
N
QV
V
---
Y
Q
------
Y
P
T
W
Y
Y
D
V
-
S
-------
V
P
A
G
T
T
-
I
Q
--
F
K
F
I
K
K
N
G
N
---------------------------------------------------------------
23
HHSearch
46.38
15%
-42
- C2 -
1CYG
-
CDGT_GEOSE
A:
[577-666]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
Q
V
S
V
R
F
V
-
V
N
-
N
A
T
-
T
-
N
L
G
Q
N
I
Y
I
-
V
G
NVY
E
---
L
---
G
N
W
D
T
S
------
K
A
I
-
G
P
M
F
--
N
QV
V
---
Y
S
------
Y
P
T
W
Y
I
D
V
-
S
-------
V
P
E
G
K
T
-
I
E
--
F
K
F
I
K
K
D
S
Q
G
N
V
----------
T
W
E
S
G
S
N
H
V
Y
-------
T
T
-------------------------------
5
Fugue
46.01
9%
6
- C2 -
1L0Q
-
?
A:
[1-391]
----------
S
T
F
A
Y
I
A
N
S
E
S
D
N
I
S
V
I
D
V
T
S
N
K
V
T
----
A
T
-----
I
P
V
--------------
G
S
N
P
M
G
-
A
V
I
S
P
D
G
T
K
V
Y
V
A
N
A
H
S
N
D
-
V
S
I
I
-
D
T
A
T
N
N
V
I
A
T
V
P
A
G
S
S
P
-------
Q
G
V
A
V
S
P
D
G
K
Q
V
Y
V
T
N
M
A
S
S
T
L
S
V
I
D
T
T
S
N
-
T
V
A
G
T
V
K
T
G
K
S
P
L
G
-----
L
A
L
S
P
D
G
K
K
L
Y
V
T
N
N
G
D
K
T
V
-----
S
V
I
N
T
V
T
K
A
V
I
N
T
V
S
V
G
R
S
P
K
G
I
A
V
T
P
D
G
T
K
V
Y
V
A
N
F
D
S
M
S
I
S
V
I
D
T
V
T
N
----
S
V
I
D
T
V
K
V
E
A
A
P
S
G
I
A
V
N
P
E
G
T
K
A
Y
V
T
N
V
D
K
Y
F
N
T
V
S
M
I
D
T
G
T
N
K
I
T
A
R
I
P
V
G
P
D
P
A
G
I
A
V
T
----------------
P
D
G
K
K
V
Y
V
A
L
S
----
F
N
-
T
V
S
V
I
D
T
A
T
N
-
T
I
-
T
A
T
M
A
-
V
-
G
K
N
P
Y
A
-
S
G
---
Q
---
F
---
I
G
S
I
P
V
------
Q
P
V
-
Y
-
P
S
--
A
--
D
---
F
K
S
NITSG
Y
I
F
L
S
E
P
V
-
Q
-------
F
T
D
L
-
S
-
K
D
AT
E
W
K
W
D
F
G
D
G
S
S
S
K
K
-
Q
N
P
T
H
T
--
Y
S
E
T
G
I
Y
T
V
-------
R
L
T
V
S
N
S
N
G
T
D
S
Q
I
S
T
V
N
V
-
V
L
K
G
S
P
T
P
S
----
22
HHSearch
45.87
12%
-46
- C2 -
1VEM
-
AMYB_BACCE
A:
[419-491]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
Q
T
I
V
-
V
K
-
N
V
P
-
T
T
I
-
G
D
T
V
Y
I
-
T
G
---
N
RAE
L
---
G
S
W
D
T
K
------
Q
Y
--
P
-
I
Q
L
Y
Y
--
D
---
S
H
------
S
N
D
W
R
G
N
V
-
V
-------
L
P
A
E
-
R
N
I
E
--
F
K
A
F
I
K
S
K
D
G
T
-------------------------------------------------------------
21
HHSearch
45.64
19%
-26
- C2 -
2Z0B
-
GPCP1_HUMAN
A:
[7-75]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
S
Q
V
A
F
E
-
I
R
-
G
T
L
-
L
-
P
-
G
E
V
F
A
I
-
C
G
---
S
CDA
L
---
G
N
W
N
P
Q
------
N
A
V
-
A
-
L
L
--
P
--
E
---
N
D
TGE---
S
M
L
W
K
A
T
I
-
V
-------
L
S
R
G
V
S
-
V
Q
--
Y
R
Y
F
K
-------------------------------------------------------------------
28
HHSearch
43.54
21%
-26
- C2 -
1D3C
-
CDGT2_BACCI
A:
[584-658]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
Q
V
S
V
R
F
V
-
V
N
-
N
A
T
-
T
-
A
L
G
Q
N
V
Y
L
-
T
G
SVS
E
---
L
---
G
N
W
D
P
A
------
K
A
I
-
G
P
M
Y
--
N
QV
V
---
Y
Q
------
Y
P
N
W
Y
Y
D
V
-
S
-------
V
P
A
G
K
T
-
I
E
--
F
K
F
L
K
K
Q
G
S
---------------------------------------------------------------
19
HHSearch
43.10
20%
5
- C2 -
4CFE
1
AAKB1_HUMAN
B:
[94-170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
T
V
F
R
-
W
--
T
G
----
G
-
G
K
E
V
Y
L
-
S
G
---
S
---
F
---
N
N
W
---------
S
K
L
-
P
-
L
T
--
R
--
S
-----------
H
N
N
F
V
A
I
L
-
D
-------
L
P
E
G
-
E
-
H
Q
--
Y
K
F
F
V
--
D
G
Q
W
T
H
D
P
S
E
P
I
V
T
S
Q
L
G
T
V
N
N
I
I
Q
----------------------------------------
29
HHSearch
41.95
17%
-36
- C2 -
3AML
5
GLGB_ORYSJ
A:
[66-131]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
Y
R
-
E
W
-
A
P
A
-----
A
Q
E
A
Q
L
-
I
G
---
E
---
F
---
N
N
W
N
-
G
------
A
K
H
-
K
-
M
E
--
K
------
D
K
------
F
G
I
W
S
I
K
I
-
S
H
VNGKPA
I
P
H
N
-
S
-
K
---
V
K
F
R
F
R
H
G
G
G
--------------------------------------------------------------
34
HHSearch
39.58
15%
-21
* C2 *
3K1D
-
GLGB_MYCTU
A:
[146-206]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
F
A
-
V
W
-
A
P
N
-----
A
K
G
V
S
L
-
I
G
---
E
---
F
---
N
G
W
N
G
-------
H
E
A
-
P
-
M
R
--
V
--
L
---
G
P
------
S
G
V
W
E
L
F
W
-
P
D------
F
P
C
D
-
G
--
L
--
Y
K
F
R
V
H
G
A
D
G
--------------------------------------------------------------
24
HHSearch
39.58
15%
-34
- C2 -
1M7X
-
GLGB_ECOLI
A:
[138-197]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
F
S
-
V
W
-
A
P
N
-----
A
R
R
V
S
V
-
V
G
---
Q
---
F
---
N
Y
W
D
G
-------
R
R
H
-
P
-
M
R
--
L
--
R
---
K
E
------
S
G
I
W
E
L
F
I
P
G
-------
A
H
N
G
-
Q
-
L
---
Y
K
Y
E
M
I
D
A
N
G
--------------------------------------------------------------
User Run . : Multi Template Modeling Result:
(2 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
M
R
V
Y
S
L
L
F
M
M
L
F
A
L
SIGAN
A
Q
V
K
F
F
TDVNS
K
Q
I
K
T
L
Q
V
K
V
A
G
E
L
ISEP
Y
I
ALGGE
E
Q
I
E
I
N
FDGLGSG
Y
T
R
Y
A
Y
N
V
V
HCNADWTQSQL
S
P
I
E
Y
MNGFQGT
T
I
D
D
F
A
N
SIGTTTQYS
N
Y
R
L
LLPND
D
V
Q
F
K
VSG
N
Y
A
I
Q
V
YNEDTP
D
Q
I
I
F
T
A
C
F
S
V
V
E
P
V
V
N
I
S
A
SVSGNTDIDTNQS
H
Q
Q
V
S
F
N
INNKNF
P
I
TYPQT
D
L
K
I
F
V
Y
QDNRRDNAVTDL
Q
P
M
S
I
L
E
N
Q
I
S
Y
T
YNR
N
L
IFPAGN
E
Y
R
R
M
E
F
L
SNKYN
G
M
H
V
E
N
I
SFHNP
Y
Y
N
V
E
L
M
T
DYRRDKGTYQYDQDQD
G
R
F
F
I
R
CSDCNDPDTEA
D
Y
Y
I
V
H
F
T
L
ACDPLPDG
S
V
Y
L
N
G
E
L
F
N
N
V
L
D
E
K
S
KMGYNF
E
T
K
Q
Y
E
K
A
V
L
L
KQGSY
N
Y
Q
Y
L
F
V
PTGSSVGQTGPIEG
N
Y
Y
Q
T
QN
E
Y
S
I
Y
V
Y
Y
RPMGAR
Y
D
R
L
I
G
V
T
T
VRNEMQVF
55
59.57
100%
3
- C- -
M055
-
A:
[2-448]
M
K
M
R
V
Y
S
L
L
F
M
M
L
F
A
L
S
I
G
A
N
A
Q
V
K
F
F
T
D
V
N
S
K
Q
I
K
T
L
Q
V
K
V
A
G
E
L
I
S
E
P
Y
I
A
L
G
G
E
E
Q
I
E
I
N
F
D
G
L
G
S
G
Y
T
R
Y
A
Y
N
V
V
H
C
N
A
D
W
T
Q
S
Q
L
S
P
I
E
Y
--------------------
Q
Y
S
N
Y
R
L
L
L
P
N
D
D
V
Q
F
K
V
S
G
N
Y
A
I
Q
V
Y
N
E
D
T
P
D
Q
I
I
F
T
A
C
F
S
V
V
E
P
V
V
N
I
S
A
S
V
S
-------
N
Q
S
H
Q
Q
V
S
F
N
I
N
N
K
N
F
P
I
T
Y
P
Q
T
D
L
K
I
F
V
Y
Q
D
N
R
R
D
N
A
V
T
D
L
Q
P
M
S
I
L
E
N
Q
I
S
Y
T
Y
N
R
N
L
I
F
P
A
G
N
E
Y
R
R
M
E
F
L
S
N
K
Y
N
G
M
H
V
E
N
I
S
F
H
N
P
Y
Y
N
V
E
L
M
T
D
Y
R
R
D
K
G
T
Y
Q
Y
D
Q
D
Q
D
G
R
F
F
I
R
C
S
D
C
N
D
P
D
T
E
A
D
Y
Y
I
V
H
F
T
L
A
C
D
P
L
P
D
G
S
V
Y
L
N
G
E
L
F
N
N
V
L
D
E
K
S
K
M
G
Y
N
F
E
T
K
Q
Y
E
K
A
V
L
L
K
Q
G
S
Y
N
Y
Q
Y
L
F
V
P
T
G
S
S
V
G
Q
T
G
P
I
E
G
N
Y
Y
Q
T
Q
N
E
Y
S
I
Y
V
Y
Y
R
P
M
G
A
R
Y
D
R
L
I
G
V
T
T
V
R
N
E
M
Q
V
F
54
57.11
100%
8
- C- -
M054
-
A:
[2-435]
M
K
M
R
V
Y
S
L
L
F
M
M
L
F
A
L
S
I
G
A
N
A
Q
V
K
F
F
T
D
V
N
S
K
Q
I
K
T
L
Q
V
K
V
A
G
E
L
I
S
E
P
Y
I
A
L
G
G
E
E
Q
I
E
I
N
F
D
G
L
G
S
G
Y
T
R
Y
A
Y
N
V
V
H
C
N
A
D
W
T
Q
S
Q
L
S
P
I
E
Y
--------------------
Q
Y
S
N
Y
R
L
L
L
P
N
D
D
V
Q
F
K
V
S
G
N
Y
A
I
Q
V
Y
N
E
D
T
P
D
Q
I
I
F
T
A
C
F
S
V
V
E
P
V
V
N
I
S
A
S
V
S
-------
N
Q
S
H
Q
Q
V
S
F
N
I
N
N
K
N
F
P
I
T
Y
P
Q
T
D
L
K
I
F
V
Y
Q
D
N
R
R
D
N
A
V
T
D
L
Q
P
M
S
I
L
E
N
Q
I
S
Y
T
Y
N
R
N
L
I
F
P
A
G
N
E
Y
R
R
M
E
F
L
S
N
K
Y
N
G
M
H
V
E
N
I
S
F
H
N
P
Y
Y
N
V
E
L
M
T
D
Y
R
R
D
K
G
T
Y
Q
Y
D
Q
D
Q
D
G
R
F
F
I
R
C
S
D
C
N
D
P
D
T
E
A
D
Y
Y
I
V
H
F
T
L
A
C
D
P
L
P
D
G
S
V
Y
L
N
G
E
L
F
N
N
V
L
D
E
K
S
K
M
G
Y
N
F
E
T
K
Q
Y
E
K
A
V
L
L
K
Q
G
S
Y
N
Y
Q
Y
L
F
V
P
T
G
S
S
V
G
Q
T
G
P
I
E
G
N
Y
Y
Q
T
Q
N
E
Y
S
I
Y
V
Y
Y
R
P
M
G
A
R
Y
D
R
L
I
G
V
T
T
V
R
N
E
M
Q
V
F