@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ORNT2_HUMAN: (2015-12-08 )
MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEAY
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------.........10........20...--....---.30.......---------.40--------.-----------.-----------......50...-.....-60...-.....-70-........80.-------.---.------.....90-........------.--100.......110.....--..120...-----...----.130.......140..---------....--.150.......160.......-170-------------..-------...------------------....180.......190---------------.....-....200...---....210...---....220-------...------.---..--------------.-------..230.--......240-----...----...----..------------250.-----------.---.--.....260.----..----.-----...270-......-----...-------280.......290-----------........300------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------MKSGPG
I
Q
A
A
I
D
LTAGAAG
G
T
A
C
V
--
L
TGQ---PF
D
T
I
K
V
K
M
Q
---------
T
F
P
--------
D
-----------
L
-----------
Y
K
G
L
T
D
C
F
L
K
T
-
Y
A
Q
V
G
-
L
R
G
FY-KGT
G
P
-
A
L
-
M
A
Y
VAEN
S
V
L
F
-------
M
---
C
------
Y
G
F
C
Q
Q
--
F
V
R
K
V
AGM------D--
K
Q
A
K
L
S
D
L
Q
T
A
AA
G
S
F
A
S
--
A
F
A
A
L
AL
C
-----
P
T
E
----
L
V
K
C
R
L
Q
T
M
Y
E
MEMSG---------K
I
A
K--SH
N
T
I
W
S
V
V
K
G
I
L
KKDGP
L
G
F
-
Y
---------------
H
G
-------
L
S
S
------------------
T
L
L
Q
EVP
G
Y
F
F
F
FG
G
-----------------
Y
E
L
S
R
-
S
F
F
ASGRSKD---ELG
P
V
H
L
M
LS---G
G
V
A
G
---------
I
C
L
------
W
---
L
V
--------------
V
-------
F
P
V
D
C
I
--
K
S
R
I
Q
V
L
S
------
M
Y
G----KQA----
G
F
------------
I
G
-
T
-----------
L
---
L
--
S
V
V
RNE
G
I
V
----
A
L
----
Y
-----
S
G
L
K
---
A
T
M
I
R
A
-----IPA-------N
G
A
L
F
V
A
Y
E
Y
S
R
------------
K
M
M
M
K
Q
LEAY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.62
24%
-68
- C3 -
4C9H
5
ADT2_YEAST
A:
[25-302]
--------------------------------------------------------------------------------------------------------
I
D
F
L
M
G
G
V
S
A
A
V
A
K
--
T
A
A
S
---
P
I
E
R
V
K
L
L
I
Q
N
Q
D
E
M
L
K
Q
G
T
L
D
--------
R
-----------
K
-----------
Y
A
G
I
L
D
C
F
K
R
T
-
A
T
Q
E
G
-
V
I
S
F
W
-
R
G
N
T
A
-
N
V
-
I
R
Y
F
P
T
Q
A
L
N
F
-----------------------
A
--
F
K
D
K
I
K
A
M
------
F
--
G
F
K
K
E
E
G
Y
A
K
W
F
A
G
N
L
A
S
--
G
G
A
A
G
A
L
S
L
L
FV
Y
S
L
D
----
Y
A
R
T
R
L
A
A
D
S
-----------------
A
R
--
Q
F
N
G
L
I
D
V
Y
K
K
T
L
K
S
D
G
V
A
G
L
-
Y
---------------
R
G
-------
F
L
P
------------------
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
-----------------
Y
--------------
D
---
S
L
K
--------------------------
L
A
S
F
L
L
G
W
---
V
V
--------------
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
--
R
R
R
M
M
M
T
S
------
G
Q
A
V---
K
Y
D
----
G
A
------------
F
D
-
C
-----------
L
---
R
--
K
I
V
A
A
E
G
V
G
----
S
L
----
F
-----
K
G
C
G
---
A
N
I
L
R
G
-----
V
A
G
-------
A
G
V
I
S
M
Y
D
Q
L
Q
M
------------
I
L
F
G
K
K
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.26
25%
-76
- C3 -
4C9J
4
ADT3_YEAST
A:
[35-306]
---------------------------------------------------------------------------------------------------
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
--
L
I
-
Q
---
N
Q
D
E
M
-
I
K
Q
G
---------
T
L
D
--------
K
-----------
K
-----------
Y
S
G
I
V
D
C
F
K
R
T
-
A
K
Q
E
G
-
L
I
S
F
W
-
R
G
N
T
A
-
N
V
-
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
---
M
------
F
G
F
K
K
E
EG
Y
G
K
W
F
A
G
-------------------
N
L
A
S
G
G
A
A
G
--
A
L
S
L
L
F
V
Y
-----
S
L
D
----
F
A
R
T
R
L
A
A
D
A
K
S
---------------
A
R
--
Q
F
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
-
Y
---------------
R
G
-------
F
M
P
------------------
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
-----------------
F
--------------
D
---
S
L
K
---------------------------F
L
L
G
--
W
---
V
V
--------------
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
--
R
R
R
M
M
M
T
S
------
G
Q
A
V---
K
Y
N
----
G
A
------------
I
D
-
C
-----------
L
---
K
--
K
I
V
A
S
E
G
V
G
----
S
L
----
F
-----
K
G
C
G
---
A
N
I
L
R
S
-----
V
A
G
-------
A
G
V
I
S
M
Y
D
Q
L
Q
M
------------
I
L
F
G
K
K
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
75.27
19%
-102
* C4 *
4R5O
3
?
A:
[2-427]
------------------------------------------------------------------DDCEDLHLGNLAH
Y
P
N
V
L
K
GTFPT
E
S
Q
V
L
E
L
G
E
T
L
E
I
T
P
E
L
L
N
P
E
G
A
T
Y
S
W
L
--
V
N
G
K
---
E
Y
S
T
E
P
T
F
S
Y
---------
K
I
D
--------
N
-----------
P
-----------
C
R
A
D
L
S
C
I
I
K
N
K
Y
G
K
V
E
M
S
T
S
F
S
-
S
N
H
N
F
-
S
K
G
F
F
Y
V
A
D
G
T
F
N
F
-------
Y
---
D
------
T
E
K
K
T
A
--
Y
Q
D
C
Y
A
S
L
------
N
AG
K
T
L
G
I
G
N
Y
D
S
A
N
I
I
H
S
N
G
--
K
F
Y
L
L
V
G
T
-----
S
T
S
NRDH
F
Y
I
V
D
A
K
T
L
Y
-
Y
E
N
S
A
---------
V
V
G
A
NL
S
G
L
T
I
L
N
E
Q
Y
G
L
V
T
G
D
G
I
R
R
I
D
L
---------------
K
S
-------
L
N
N
------------------
V
R
I
K
N
-
E
R
L
L
C
F
Y
N
S
-----------------
I
I
Y
N
G
-
K
V
L
S
N
D
T
Y
K
D
---
E
-
S
K
V
K
Y
Y
D
V
---
N
E
L
I
A
AKEGEA
P
A
V
T
E
L
------
D
---
I
I
QK
Q
K
I
N
F
V
L
A
KDG
N
V
-------
Y
T
L
E
S
A
--
D
N
G
C
N
I
V
K
I
K
NDF
T
L
E
K
----
V
F
A
----
N
F
QPAKGPYHSSPT
I
G
M
V
A
S
ETEN-----
I
---
I
--
Y
L
V
S
T
D
G
A
I
----
Y
K
----
Y
I
LGDS
D
S
L
K
---
A
P
F
I
A
A
E
S
G
V
S
I
T
A
P
L
Q
L
NQQ
S
G
E
L
Y
V
T
Y
T
E
E
R
------------
K
D
E
S
K
I
V
V
Y
S
KDGKVL
H
T
V
D
CGESVPS
Q
I
L
F
NN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
73.81
16%
-115
- C4 -
2VDU
-
TRM82_YEAST
B:
[2-436]
--------------------------------------------------------------------------------------------------
S
V
I
H
P
L
Q
N
L
L
T
S
R
D
G
S
L
V
F
A
--
I
I
K
N
---
C
I
L
S
F
K
Y
Q
S
P
N
--------
H
W
E
--------
F
-----------
A
-----------
G
K
W
S
D
D
F
P
I
Y
S
-
Y
-----
I
R
N
L
R
-
L
T
S
D
E
-
S
R
-
L
I
A
C
A
D
S
D
K
S
L
-------
L
---
V
------
F
D
V
D
K
T
--
S
-
K
N
V
L
K
L
------
R
--
K
R
F
C
F
S
K
R
P
N
A
I
S
I
A
E
D
D
--
T
T
V
I
I
A
D
K
-----
F
G
D
----
V
Y
S
I
D
I
N
S
I
P
E
E
K
F
T
Q
---------
E
P
I
L
--
G
H
V
S
M
L
T
D
V
H
L
I
K
D
S
D
G
H
Q
F
I
-
I
---------------
T
S
DRDE
H
I
K
I
S
H
Y
PQCFIVD
K
W
L
F
GHKHFV
S
S
I
C
C
G
K
D
Y
L
L
L
S
A
G
GDD
K
I
F
A
W
DWKTGKNL
S
T
F
D
Y
N
-
S
L
I
K
P
Y
L
N
D
Q
---
H
L
A
I
I
E
F
A
V
S
---
K
I
I
K
S
---------
K
N
L
------
P
---
F
V
--------------
A
-------
F
F
V
E
A
T
--
K
-
C
I
I
I
L
E
------
M
S
E
----
K
Q
K
----
G
D
------------
L
A
-
L
K
Q
I
I
T
F
P
Y
NVI
S
---
L
--
S
A
H
N
D
E
F
Q
V
----
T
L
D
N
KE
S
-----
S
G
V
Q
KNF
A
K
F
I
E
Y
-----
N
L
N
-------
E
N
S
F
V
V
N
N
E
K
S
N
------------
E
F
D
S
A
I
I
Q
S
V
Q
G
DSNLVTKKEEIYPLYNVSSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
71.67
26%
-60
- C3 -
2LCK
-
UCP2_MOUSE
A:
[20-299]
---------------------------------------------------------------------------------------------------------------
A
G
T
A
A
C
I
A
D
L
I
T
F
---
P
L
D
T
A
K
V
R
L
Q
---------
I
Q
G
--------
E
SQG
L
V
R
T
A
ASA
Q
-----------
Y
R
G
V
L
G
T
I
L
T
M
-
V
R
T
E
G
-
P
R
S
L
Y
-
N
G
L
V
A
-
G
L
-
Q
R
Q
M
S
F
A
S
V
R
I
-------
G
---
L
------
Y
D
S
V
K
Q
--
F
Y
T
K
--
G
S
------
E
--
H
A
G
I
G
S
R
L
---
L
A
G
S
T
T
G
--
A
L
A
V
A
V
A
Q
-----
P
T
D
----
V
V
K
V
R
F
Q
A
----
Q
A
R
A
---------
G
G
G
R
--
R
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
-
W
---------------
K
G
-------
T
S
P
------------------
N
V
A
R
N
A
I
V
N
C
A
E
L
V
T
-----------------
Y
D
L
I
K
D
T
L
L
K
A
N
L
M
T
D
---
D
L
-
P
C
H
F
T
S
A
---
F
G
-
A
G
---------
F
C
T
------
T
---
V
I
--------------
A
-------
S
P
V
D
V
V
--
K
T
R
Y
-
M
N
S
------
A
L
G
----
Q
Y
H
----
S
A
------------
G
H
-
C
-----------
A
---
L
--
T
M
L
R
K
E
G
P
R
----
A
F
----
Y
-----
K
G
F
M
---
P
S
F
L
R
L
-----
G
S
W
-------
N
V
V
M
F
V
T
Y
E
Q
L
K
------------
R
A
L
M
A
A
Y
Q
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.59
25%
-78
- C3 -
4C9Q
5
ADT3_YEAST
A:
[35-306]
---------------------------------------------------------------------------------------------------
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
I
--
L
I
-
Q
---
N
Q
D
E
M
-
I
K
Q
G
---------
T
L
D
--------
K
-----------
K
-----------
Y
S
G
I
V
D
C
F
K
R
T
-
A
K
Q
E
G
-
L
I
S
F
W
-
R
G
N
T
A
-
N
V
-
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
---
M
------
F
G
F
K
K
E
G-
Y
G
K
W
F
A
G
-------------------
N
L
A
S
G
G
A
A
G
--
A
L
S
L
L
F
V
Y
-----
S
L
D
----
F
A
R
T
R
L
A
A
D
A
K
S
---------------
A
R
--
Q
F
N
G
L
T
D
V
Y
K
K
T
L
K
S
D
G
I
A
G
L
-
Y
---------------
R
G
-------
F
M
P
------------------
S
V
V
G
I
V
V
Y
R
G
L
Y
F
G
M
-----------------
F
--------------
D
---
S
L
K
P
--
L
---------------------
F
L
A
S
F
L
L
G
W
---
V
V
--------------
T
T
G
A
S
T
C
S
Y
P
L
D
T
V
--
R
R
R
M
M
M
T
S
------
G
Q
A
V---
K
Y
N
----
G
A
------------
I
D
-
C
-----------
L
---
K
--
K
I
V
A
S
E
G
V
G
----
S
L
----
F
-----
K
G
C
G
---
A
N
I
L
R
S
-----
V
A
G
-------
A
G
V
I
S
M
Y
D
Q
L
Q
M
------------
I
L
F
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.53
21%
-77
- C3 -
1OKC
10
ADT1_BOVIN
A:
[13-281]
---------------------------------------------------------------------------------------------------------------
A
G
G
V
A
A
A
--
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
VQHASKQI-
S
A
E
--------
K
-----------
Q
-----------
Y
K
G
I
I
D
C
V
V
R
I
-
P
K
E
Q
G
-
F
L
S
F
W
-
R
G
N
L
A
-
N
V
-
I
R
Y
F
P
T
Q
A
L
N
F
-------
A
---
F
------
K
D
K
Y
K
Q
--
I
F
--
L
G
G
V
------
D
--
R
H
K
Q
---
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
--
P
L
D
----
F
A
R
T
R
L
A
A
D
V
G
---
K
G
---------
A
A
Q
R
--
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
-
Y
---------------
Q
G
-------
F
N
V
------------------
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
-----------------
Y
D
T
A
K
-
G
M
L
P
D
P
K
N
---------
V
H
I
I
V
S
---
W
M
I
A
Q
---------
T
V
T
------
A
V
A
G
L
V
--------------
S
-------
Y
P
F
D
T
V
--
R
R
R
M
M
M
Q
S
G-----
R
K
G
----
A
D
I
----
M
Y
------------
T
G
-
T
-----------
V
D
C
W
R
--
K
I
A
K
D
E
G
P
K
----
A
F
----
F
-----
K
G
A
W
---
S
N
V
L
R
G
-----
M
G
G
-------
A
F
V
L
V
L
Y
D
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
68.35
21%
-79
- C3 -
2C3E
4
ADT1_BOVIN
A:
[13-281]
---------------------------------------------------------------------------------------------------------------
A
G
G
V
A
A
A
--
I
S
K
T
A
V
A
P
I
E
R
V
K
L
L
L
Q
VQHASKQI-
S
A
E
--------
K
-----------
Q
-----------
Y
K
G
I
I
D
C
V
V
R
I
-
P
K
E
Q
G
-
F
L
S
F
W
-
R
G
N
L
A
-
N
V
-
I
R
Y
F
P
T
Q
A
L
N
F
-------
A
---
F
------
K
D
K
Y
K
Q
--
I
F
--
L
G
G
V
------
D
--
R
H
K
Q
---
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
G
A
T
S
L
C
F
V
Y
--
P
L
D
----
F
A
R
T
R
L
A
A
D
V
G
---
K
G
---------
A
A
Q
R
--
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
-
Y
---------------
Q
G
-------
F
N
V
------------------
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
-----------------
Y
D
T
A
K
-
G
M
L
P
D
P
K
N
---------
V
H
I
I
V
S
---
W
M
I
A
Q
---------
T
V
T
------
A
V
A
G
L
V
--------------
S
-------
Y
P
F
D
T
V
--
R
R
R
M
M
M
Q
S
G-----
R
K
G
----
A
D
I
----
M
Y
------------
T
G
-
T
-----------
V
D
C
W
R
--
K
I
A
K
D
E
G
P
K
----
A
F
----
F
-----
K
G
A
W
---
S
N
V
L
R
G
-----
M
G
G
-------
A
F
V
L
V
L
Y
D
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
65.63
23%
-62
- C3 -
2LCK
-
UCP2_MOUSE
A:
[14-303]
-------------------------------------------------------------------------------------------------------
T
V
K
F
L
G
A
G
T
A
A
C
I
A
D
--
L
I
T
F
---
P
L
D
T
A
K
V
R
L
Q
---------
I
Q
G
--------
E
-----------
S
QG
L
V
R
T
A
ASAQ
Y
R
G
V
L
G
T
I
L
T
M
-
V
R
T
E
G
-
P
R
S
L
Y
-
N
G
L
V
A
-
G
L
-
Q
R
Q
M
S
F
A
S
V
R
I
-------
G
---
L
------
Y
D
S
V
K
Q
--
F
Y
T
K
G
S
-------------
E
H
A
G
I
G
S
R
L
L
A
G
S
T
T
G
--
A
L
A
V
A
V
A
Q
-----
P
T
D
----
V
V
K
V
R
F
Q
A
Q
A
R
A
G
-------------
G
G
R
--
R
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
-
W
---------------
K
G
-------
T
S
P
------------------
N
V
A
R
N
A
I
V
N
C
A
E
L
V
T
-----------------
Y
D
L
I
K
-
D
T
L
L
K
A
N
L
M
----
T
D
D
L
P
C
H
F
T
S
---
A
F
G
A
G
---------
F
C
T
------
T
---
V
I
--------------
A
-------
S
P
V
D
V
V
--
K
T
R
Y
M
N
S
A
------
L
-
G
----
Q
Y
H
----
S
A
------------
G
H
-
C
-----------
A
---
L
--
T
M
L
R
K
E
G
P
R
----
A
F
----
Y
-----
K
G
F
M
---
P
S
F
L
R
L
-----
G
S
W
-------
N
V
V
M
F
V
T
Y
E
Q
L
K
------------
R
A
L
M
A
A
Y
Q
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
65.15
18%
-68
- C3 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
--
T
A
V
A
---
P
I
E
R
V
K
L
L
L
Q
---------
V
Q
H
--------
A
SKQISAEK---
Q
-----------
Y
K
G
I
I
D
C
V
V
R
I
-
P
K
E
Q
G
-
F
L
S
F
W
-
R
G
N
L
A
-
N
V
-
I
R
Y
F
P
T
Q
A
L
N
F
-------
A
---
F
------
K
D
K
Y
K
Q
--
I
F
L
G
G
V
D
R
------
H
--
K
Q
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
G
--
A
T
S
L
C
F
V
Y
-----
P
L
D
----
F
A
R
T
R
L
A
A
D
V
G
K
G
A
------------
A
Q
R
--
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
-
Y
---------------
Q
G
-------
F
N
V
------------------
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
-----------------
Y
D
T
A
K
-
G
M
L
P
D
P
K
------
N
V
H
I
I
V
S
W
M
I
---
A
Q
T
V
T
---------
A
V
A
------
G
---
L
V
--------------
S
-------
Y
P
F
D
T
V
--
R
R
R
M
M
M
Q
S
------
G
R
K
GADI
M
Y
T
----
G
T
------------
V
D
-
C
-----------
W
---
R
--
K
I
A
K
D
E
G
P
K
----
A
F
----
F
-----
K
G
A
W
---
S
N
V
L
R
G
-----
M
G
--------
G
A
F
V
L
V
L
Y
D
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
65.12
18%
-69
- C3 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------------------------------------------------
D
Q
A
L
S
F
L
K
D
F
L
A
G
G
V
A
A
A
I
S
K
--
T
A
V
A
---
P
I
E
R
V
K
L
L
L
Q
---------
V
Q
H
ASKQISAE
K
-----------
Q
-----------
Y
K
G
I
I
D
C
V
V
R
I
-
P
K
E
Q
G
-
F
L
S
F
W
-
R
G
N
L
A
-
N
V
-
I
R
Y
F
P
T
Q
A
L
N
F
-------
A
---
F
------
K
D
K
Y
K
Q
--
I
F
L
G
G
V
D
R
------
H
--
K
Q
F
W
R
Y
F
A
G
N
L
A
S
G
G
A
A
G
--
A
T
S
L
C
F
V
Y
-----
P
L
D
----
F
A
R
T
R
L
A
A
D
---
V
G
K
G
---------
A
A
Q
R
--
E
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
-
Y
---------------
Q
G
-------
F
N
V
------------------
S
V
Q
G
I
I
I
Y
R
A
A
Y
F
G
V
-----------------
Y
D
T
A
K
-
G
M
L
P
D
P
K
N
V
H
------
I
I
V
S
W
M
I
---
A
Q
T
V
T
---------
A
V
A
------
G
---
L
V
--------------
S
-------
Y
P
F
D
T
V
--
R
R
R
M
M
M
Q
S
------
G
R
K
----
G
A
D
IMYT
G
T
------------
V
D
-
C
-----------
W
---
R
--
K
I
A
K
D
E
G
P
K
----
A
F
----
F
-----
K
G
A
W
---
S
N
V
L
R
G
-----
M
G
G
-------
A
F
V
L
V
L
Y
D
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
63.74
24%
-73
* C3 *
1OKC
8
ADT1_BOVIN
A:
[5-204]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
L
K
D
F
L
A
G
G
V
A
A
--
A
I
S
K
T
A
V
A
-----
P
I
E
----
R
V
K
L
L
L
Q
V
Q
H
A
S
K
Q
I
S
----------
A
E
K
--
Q
Y
K
G
I
I
D
C
V
V
R
I
P
K
E
Q
G
F
L
S
F
-
W
---------------
R
G
-------
N
L
A
------------------
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
-----------------
K
D
K
Y
K
-
Q
I
F
L
G
G
V
D
R
H
KQ
F
W
R
Y
F
A
G
N
L
A
S
---
G
G
A
A
G
---------
A
T
S
------
L
---
C
F
--------------
V
-------
Y
P
L
D
F
A
--
R
T
R
L
A
A
D
V
------
G
K
G
AAQR
E
F
T
----
G
L
------------
G
N
-
C
-----------
I
---
T
--
K
I
F
K
S
D
G
L
R
----
G
L
----
Y
-----
Q
G
F
N
---
V
S
V
Q
G
I
-----
I
I
Y
-------
R
A
A
Y
F
G
V
Y
D
T
A
K
------------
G
M
L
P
D
P
K
N
V
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
63.22
18%
-67
* C2 *
4UI9
-
ANC2_HUMAN
N:
[15-730]
RPGQELLVAWNTVSTEELRAAVEVLRGHVLEEWFVEVLQNDLQANISPEFWNAISQCENSACLLLLLDAFGLLESRLDPYLRSLELLEKWTRLG
L
L
M
G
T
G
A
Q
G
L
R
E
E
V
H
T
M
L
R
G
V
L
F
F
--
S
T
P
-------------
R
---------
T
F
Q
--------
E
-----------
M
-----------
I
Q
R
L
Y
G
C
F
L
R
V
-
Y
M
Q
S
K
-
R
K
G
D
P
-
E
L
E
G
E
-
L
D
-
S
R
Y
A
R
R
R
Y
Y
R
L
-------
L
--------------
Q
S
--
P
L
W
C
R
Q
A
L
------
E
--
Q
F
H
Q
L
S
Q
V
L
H
R
L
S
L
L
E
R
V
--
S
A
E
A
V
T
T
T
-----
L
H
Q
----
V
T
R
E
R
M
E
D
R
C
R
G
E
Y
E
R
---------
S
F
L
R
--
E
F
H
K
W
I
E
R
V
V
G
W
L
G
K
V
F
T
L
------------------------------
R
------------------
R
W
R
C
H
V
Q
R
F
F
Y
R
I
Y
A
-----------------
S
L
R
I
E
-
E
L
F
S
I
V
R
D
F
P
---
D
S
R
P
A
I
E
D
L
K
---
Y
C
L
E
R
------------------------------------------------------
T
D
Q
R
Q
Q
L
L
------
V
S
L
----
K
A
A
----
L
E
------------
T
R
-
L
-----------
L
---
H
--
P
G
V
N
T
C
D
I
I
----
T
L
----
Y
-----
I
S
A
I
---
K
A
L
R
V
I
-----
D
P
S
-------
M
V
I
L
E
V
A
C
E
P
I
R
------------
R
Y
L
R
T
R
E
D
T
V
RQIVAGLTDLAVELSKEPEDWVPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDNMVLI
28
Fugue
53.09
10%
-100
- C1 -
2PV0
-
DNM3L_HUMAN
A:
[34-380]
-------------------------------------------------------------------------------------------------
G
R
D
L
I
A
Y
E
V
K
A
N
Q
R
N
I
E
D
I
C
I
--
C
C
G
S
---
L
-----
Q
V
H
T
---------
Q
H
P
--------
L
-----------
F
-----------
E
G
G
I
C
A
P
C
K
D
K
-
F
L
D
A
L
-
F
L
-
Y
D
-
D
D
G
Y
Q
-
S
Y
-
C
S
I
C
C
S
G
E
T
L
L
-------
I
---
C
GNPDCT
R
C
Y
C
F
E
--
C
V
D
S
L
V
G
P
------
G
--
T
S
G
K
V
H
A
M
S
N
W
V
C
Y
L
C
L
P
--
S
S
R
S
G
L
L
Q
-----
R
R
R
----
K
W
R
S
Q
L
K
A
F
Y
D
R
E
S
E
N
PLEMFETVP
V
W
R
R
--
Q
P
V
R
V
L
S
L
F
E
D
I
K
K
E
L
T
S
L
G
F
-
L
ESGSDPGQ
L
K
H
V
V
DV
T
D
-------
T
V
R
------------------
K
D
V
E
E
W
G
P
F
D
L
V
Y
G
A
-----------------
T
P
P
L
G
-
H
T
C
D
R
P
P
S
W
Y
---
L
F
Q
F
H
R
L
L
Q
Y
A
RP
K
P
G
S
P
---------
G
P
F
------
F
---
W
M
--------------
F
-------
V
D
N
L
V
L
N
K
E
D
L
D
V
A
S
R
------
F
L
E
----
M
E
P
----
V
T
------------
I
P
-
D
-----------
V
---
H
GG
S
L
Q
N
A
V
R
V
W
----
S
N
----
I
-----
P
A
I
R
---
S
R
H
W
A
L
-----
V
S
E
-------
E
E
L
S
L
L
A
Q
N
K
Q
S
SKLAAKWPTKLV
K
N
C
F
L
P
L
R
E
Y
F
K
Y
F
ST-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
49.75
15%
-80
- C2 -
2DVY
-
?
A:
[1-223]
----------------------------------------------------------------------------------------------
M
I
H
L
T
S
V
E
A
S
V
S
F
E
N
G
K
--------------------
I
V
V
R
L
P
---------------------------------------------------
I
T
R
P
-
T
S
K
I
R
-
V
K
K
I
E
-
N
G
V
G
I
-
P
V
-
S
T
R
------------------------------
K
K
--
S
F
P
S
D
E
N
L
------
R
--
D
Y
Y
I
E
W
Q
I
S
Y
A
R
D
G
K
Y
D
Y
--
E
L
S
R
M
V
R
L
-----
A
H
E
----
H
G
I
L
T
Y
N
D
I
Y
E
L
L
K
F
A
---------
D
D
V
K
--
S
Y
-----------
L
E
D
K
G
I
----------------------------
R
R
E
------------------
S
T
N
E
E
L
Y
G
F
N
I
Y
E
D
V
-----------------
Y
P
V
A
K
-
K
E
L
P
S
G
---
E
---
F
I
G
I
V
L
K
H
K
Q
---
R
A
V
G
Y
---------
Q
S
M
------
V
---
Y
V
--------------
C
-------
I
P
L
T
N
V
--
E
P
-----
S
------
L
A
G
----
R
V
A
----
R
R
------------
N
E
-
V
-----------
V
---
K
--
Y
E
V
P
V
D
L
M
K
----
E
L
----
L
-----
K
A
F
I
-----------------------------
I
A
S
E
T
H
K
------------
N
D
I
V
K
F
L
R
S
I
I------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
45.43
21%
-44
- C3 -
2LCK
-
UCP2_MOUSE
A:
[114-302]
----------------------------------------------------------------------------------------------------
A
G
I
G
S
R
L
L
A
G
S
T
T
G
A
L
A
V
--
A
V
A
Q
---
P
T
D
V
V
K
V
R
F
Q
---------
A
Q
A
--------
R
AGGGR------
R
-----------
Y
Q
S
T
V
E
A
Y
K
T
I
-
A
R
E
E
G
-
I
R
G
L
W
-
K
G
T
S
P
-
N
V
-
A
R
N
A
I
V
N
C
A
E
L
-------
V
---
T
------
Y
D
L
I
K
D
--
T
L
L
K
A
N
L
------------
M
T
D
D
L
P
C
H
F
T
S
A
F
G
A
G
--
F
C
T
T
V
I
A
S
-----
P
V
D
----
V
V
K
T
R
Y
M
N
S
A
L
G
-------------------
Q
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
-
Y
---------------
K
G
-------
F
M
P
------------------
S
F
L
R
L
G
S
W
N
V
V
M
F
V
T
-----------------
Y
E
Q
L
K
-
R
A
L
M
A
A
Y
Q
S
R
---
E
A
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
43.09
13%
-44
- C3 -
3F2E
1
?
A:
[8-90]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
A
V
A
E
Q
V
S
A
V
-
L
S
Q
Y
G
-
I
T
G
P
N
-
R
A
I
Y
Q
-
G
F
-
G
L
K
V
A
R
A
L
N
R
L
-------
G
---
G
------
G
P
A
L
V
N
--
M
I
N
G
L
K
A
Y
Y
I
S
AFN
A
--
N
P
T
V
L
D
A
V
T
D
I
I
T
G
S
P
T
G
--
Y
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
41.20
26%
-55
- C3 -
1MMF
1
?
A:
[250-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
R
G
-
L
K
M
R
Y
T
S
G
T
G
S
E
A
L
-
M
G
Y
S
E
S
K
S
M
L
Y
-------
L
E
S
R
C
------
I
-------
F
I
T
K
G
A
G
--------------
V
Q
G
L
Q
N
G
A
V
S
C
I
G
M
--
T
G
A
V
P
S
G
I
-----
R
A
V
----
L
A
E
N
L
I
A
S
M
L
D
L
E
V
A
S
---------
A
N
D
Q
TF
S
H
S
D
I
R
R
T
A
R
----------------------------------------------------------
T
L
M
Q
M
L
P
G
T
D
F
I
F
S
G
-----------------
Y
S
A
V
P
-
N
Y
D
N
M
F
A
G
S
N
---
F
D
A
E
D
F
D
D
Y
N
---
I
L
Q
R
D
---------
L
M
V
------
D
---
G
G
--------------
L
-------
R
P
V
T
E
A
--
E
T
I
A
I
R
Q
K
------
A
A
R
----
A
I
Q
----
A
V
------------
F
R
-
E
-----------
L
---
G
--
L
P
P
I
A
D
E
E
V
----
E
A
----
A
-----
T
Y
A
H
---
G
S
N
E
M
P
-----
P
R
N
-------
V
V
E
D
L
S
A
V
E
E
M
M
------------
K
R
N
I
T
G
L
D
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
40.92
26%
-59
- C3 -
1IWP
2
?
A:
[250-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
R
G
-
L
K
M
R
Y
T
S
G
T
G
S
E
A
L
-
M
G
Y
S
E
S
K
S
M
L
Y
-------
L
E
S
R
C
------
I
-------
F
I
T
K
G
A
G
--------------
V
Q
G
L
Q
N
G
A
V
S
C
I
G
M
--
T
G
A
V
P
S
G
I
-----
R
A
V
----
L
A
E
N
L
I
A
S
M
L
D
L
E
V
A
S
---------
A
N
D
Q
TF
S
H
S
D
I
R
R
T
A
R
----------------------------------------------------------
T
L
M
Q
M
L
P
G
T
D
F
I
F
S
G
-----------------
Y
S
A
V
P
-
N
Y
D
N
M
F
A
G
S
N
---
F
D
A
E
D
F
D
D
Y
N
---
I
L
Q
R
D
---------
L
M
V
------
D
---
G
G
--------------
L
-------
R
P
V
T
E
A
--
E
T
I
A
I
R
Q
K
------
A
A
R
----
A
I
Q
----
A
V
------------
F
R
-
E
-----------
L
---
G
--
L
P
P
I
A
D
E
E
V
----
E
A
----
A
-----
T
Y
A
H
---
G
S
N
E
M
P
-----
P
R
N
-------
V
V
E
D
L
S
A
V
E
E
M
M
------------
K
R
N
I
T
G
L
D
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
32.50
11%
-13
- C3 -
3FBL
-
A:
[7-37]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------
I
---
K
--
E
I
C
K
T
D
G
I
P
NIK
W
G
M
----
Y
-----
I
A
F
G
---
E
K
L
L
K
S
-----
Y
L
K
-------
M
K
A
G
S
A
S
S
D
M
I
A
------------
E
Y
I
N
N
A
I
S
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------