@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T0801: (2014-06-02 )
MIPFNAPPVVGTELDYMQSAMGSGKLCGDGGFTRRCQQWLEQRFGSAKVLLTPSCTASLEMAALLLDIQPGDEVIMPSYTFVSTANAFVLRGAKIVFVDVRPDTMNIDETLIEAAITDKTRVIVPVHYAGVACEMDTIMALAKKHNLFVVEDAAQGVMSTYKGRALGTIGHIGCFSFHETKNYTAGGEGGATLINDKALIERAEIIREKGTNRSQFFRGQVDKYTWRDIGSSYLMSDLQAAYLWAQLEAADRINQQRLALWQNYYDALAPLAKAGRIELPSIPDGCVQNAHMFYIKLRDIDDRSALINFLKEAEIMAVFHYIPLHGCPAGEHFGEFHGEDRYTTKESERLLRLPLFYNLSPVNQRTVIATLLNYFS
Atome Classification :
(20 SA)
-------------------------------------------------------------------....-..-----..-.10-.........20......------..-30.-----.......40...----.....50........60.....--------...70-........80........90........100.......110......---.---120.......130.......140.......150.......160.......170.......180.......190.......200.......210.----......220------.......-..230.......240.......250--.......260..--.....270.....--..280.....-..290.....---------------------..----300--------.---------.-----.......310-.-..---..--..320.-.-.....-.330..--..-.------------..340.--.--......350.........-360.......370....----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------MIPF-NA-----PP-VV--G
T
E
L
D
Y
M
Q
S
A
MGSGKLC------GD-GG
F
-----
T
R
R
C
Q
Q
W
L
E
Q
RF----GS
A
K
V
L
LTPSCT
A
S
L
E
M
A
A
L
L
L
--------DIQPG-D
E
V
I
MP
S
Y
T
F
V
STA
N
A
F
V
LRG
A
K
I
V
F
V
DVRPDTM
N
I
D
E
T
L
I
E
A
AITD---K---
T
R
V
I
V
P
V
HYAGVA
C
E
M
D
T
I
M
A
L
A
KKH
N
L
F
V
V
E
D
A
A
Q
G
V
M
S
T
YKGRALGTIG
H
I
G
C
F
S
F
HETKNYTAGGEG
G
A
T
L
IN
D
K
A
L
I
E
R
A
E
I
I
R
EKGT
N
R
----
S
Q
F
FRGQ--------VDK
Y
T
W
R
-
D
I
G
S
S
Y
L
M
S
D
L
Q
A
A
Y
L
W
A
Q
L
E
A
A
D
R
--
I
N
Q
Q
R
L
A
L
W
Q
N
Y
--
Y
D
A
L
A
P
L
A
KAGRI--ELPSI
P
D
G
C
V-QN
A
H
M
F
Y
I
K
L
---------------------RD----I----------D---------
D
-----
R
S
A
L
I
N
F
L
K
E
-
A
-
E
I
---
M
A
--
V
F
H
Y-I-P-LHGCP-
A
G
E
H
F
G
--
E
F-H------------GED-RY--T--
T
K
E
S
E
R
L
--
L
RL
P
L
F
YNL-SPVN
Q
R
T
V
I
A
T
L
L
N
YFS----
35
HHSearch
91.48
31%
-107
- C1 -
3DR4
2
?
A:
[28-391]
---------------------------------------------------------------------
S
V
-
A
A
-----
P
R
-
L
D
--
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
-------
S
S
V
G
R
F
-----
I
V
E
F
E
K
A
F
A
D
Y
C
----
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
--------
G
I
G
P
G
-
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
---
R
---
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
T
-
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
-------------------
N
R
R
Y
W
F
P
-
I
V
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
--
H
L
A
A
R
E
R
V
V
G
W
Y
--
E
Q
K
L
A
R
L
--
G
N
R
V
--
T
K
P
H
V
A
L
T
G
R
-
H
V
F
W
M
Y
T
V
R
L
---------------------
G
E
----
G
----------
L
ST-------
T
-----
R
D
Q
V
I
K
D
L
D
A
-
L
-
G
I
---
E
S
--
R
P
V
F
-
H
-
P
-
M
H
I
M
P
-
P
Y
A
H
L
A
-----
T
------------
D
D
L
-
K
I
--
A
--
E
A
C
G
V
D
G
--
L
N
L
P
T
H
A
G
L
-
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
V
----
5
PsiBlast_PDB
91.45
33%
-103
- C1 -
1MDO
1
ARNB_SALTY
A:
[10-379]
-------------------------------------------------------------------
F
L
P
F
-
S
R
-----
P
A
-
M
G
--
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-----------------
T
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
--------
G
I
G
E
G
-
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
---
Q
---
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
-
T
A
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
----
D
----------------
Q
A
E
V
L
-
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
--
L
N
A
R
R
A
A
I
A
A
Q
Y
--
H
Q
A
M
A
D
L
-
P
F
Q
P
L
--
S
L
P
S
W
E
H
--
I
-
H
A
W
H
L
F
I
I
R
V
---------------------
D
E
----
A
----------
R
CGI------
T
-----
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
---
G
T
--
G
L
H
F
-
R
-
A
-
A
H
T
Q
K
Y
Y
R
E
R
F
P
--
T
L
-
T
------------
L
P
D
-----
T
--
E
W
N
S
E
R
I
--
C
S
L
P
L
F
P
D
M
-
T
E
S
D
F
D
R
V
I
T
A
L
---------
1
PsiBlast_PDB
90.76
33%
-104
- C1 -
1MDX
4
ARNB_SALTY
A:
[11-379]
--------------------------------------------------------------------
L
P
F
-
S
R
-----
P
A
-
M
G
--
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-----------------
T
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
--------
G
I
G
E
G
-
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
---
Q
---
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
-
T
A
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
-----------
G
R
--------
A
P
Q
A
E
V
L
-
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
--
L
N
A
R
R
A
A
I
A
A
Q
Y
--
H
Q
A
M
A
D
L
-
P
F
Q
P
L
--
S
L
P
S
W
E
H
--
I
-
H
A
W
H
L
F
I
I
R
V
---------------------
D
E
----
A
----------
R
CGI------
T
-----
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
---
G
T
--
G
L
H
F
-
R
-
A
-
A
H
T
Q
K
Y
Y
R
E
R
F
P
--
T
L
-
T
------------
L
P
D
-----
T
--
E
W
N
S
E
R
I
--
C
S
L
P
L
F
P
D
M
-
T
E
S
D
F
D
R
V
I
T
A
L
---------
36
HHSearch
90.09
31%
-103
- C1 -
4LC3
10
?
A:
[16-386]
-------------------------------------------------------------------
F
L
P
F
-
T
R
-----
P
E
-
I
D
--
E
E
T
I
Q
G
V
V
E
V
L
R
S
G
W
I
-------
T
T
-
G
P
Q
-----
C
Q
K
F
E
A
A
L
S
E
Y
C
----
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
I
A
--------
G
V
G
P
G
-
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
E
Q
A
I
T
P
---
R
---
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
H
A
N
K
N
L
-
T
T
I
E
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
R
----
T
G
F
-------------
D
G
M
D
C
D
-
V
L
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
Q
L
P
H
L
E
R
--
F
T
A
Q
R
R
A
L
A
R
A
Y
--
F
A
A
F
D
G
G
A
A
-
A
K
L
GV
G
L
P
V
-
A
E
F
E
N
-
G
N
W
H
M
F
L
V
T
L
---------------------
P
L
----
E
RLT-------
I
---------
T
-----
R
A
E
F
M
A
Q
M
K
E
-
R
-
G
I
---
G
T
--
G
I
H
Y
-
P
-
A
-
I
H
L
F
T
-
L
Y
R
A
R
G
--
F
K
-
E
------------
G
M
F
-
P
H
--
A
--
E
R
Y
G
A
S
T
--
V
T
L
P
L
F
T
Q
M
-
T
E
G
D
V
R
R
V
V
D
A
V
N
Q
I
C
-----
34
HHSearch
89.81
32%
-100
* C1 *
1MDO
1
ARNB_SALTY
A:
[10-383]
-------------------------------------------------------------------
F
L
P
F
-
S
R
-----
P
A
-
M
G
--
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-------
T
-
G
P
K
-----
N
Q
E
L
E
A
A
F
C
R
L
T
----
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
--------
G
I
G
E
G
-
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
---
Q
---
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
-
A
I
F
S
F
H
A
I
K
N
I
-
T
C
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
----
D
----------------
Q
A
E
V
L
-
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
--
L
N
A
R
R
A
A
I
A
A
Q
Y
--
H
Q
A
M
A
D
---
L
P
F
Q
--
P
L
S
L
P
S
W
E
H
I
-
H
A
W
H
L
F
I
I
R
V
---------------------
D
E
ARC-
G
----------
I
---------
T
-----
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
---
G
T
--
G
L
H
F
-
R
-
A
-
A
H
T
Q
K
-
Y
Y
R
E
R
----
F
-
P
------------
T
L
T
L
P
D
--
T
--
E
W
N
S
E
R
I
--
C
S
L
P
L
F
P
D
M
-
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
A
-----
42
HHSearch
88.98
30%
-110
- C1 -
2OGA
5
?
A:
[39-393]
-------------------------------------------------------------------------
Y
-----
E
E
-
L
R
--
A
E
T
D
A
A
I
A
R
V
L
D
S
G
R
Y
-------
L
L
-
G
P
E
-----
L
E
G
F
E
A
E
F
A
A
Y
C
----
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
G
L
--------
G
I
G
P
G
-
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
E
K
A
I
T
P
---
R
---
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
H
G
L
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y
P
G
K
N
L
G
C
F
G
D
G
G
A
V
V
T
G
D
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
R
---------------------
Q
K
Y
S
H
E
-
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
--
W
N
G
R
R
S
A
L
A
A
E
Y
--
L
S
G
L
A
G
L
P
--
G
-
I
--
G
L
P
V
T
A
P
D
T
D
-
P
V
W
H
L
F
T
V
R
T
---------------------
E
--------------------------
R
-----
R
D
E
L
R
S
H
L
D
A
-
R
-
G
I
---
D
T
--
L
T
H
Y
-
P
V
P
-
V
H
L
S
P
-
A
Y
A
G
E
A
--
P
P
---------------
E
G
-
S
L
--
P
R
A
E
S
F
A
R
Q
V
--
L
S
L
P
I
G
P
H
L
-
E
R
P
Q
A
L
R
V
I
D
A
V
R
E
W
A
-----
43
HHSearch
87.19
30%
-118
- C1 -
4K2M
6
NTDA_BACSU
A:
[87-437]
-----------------------------------------------------------------------------------------
L
N
T
L
T
E
V
L
P
T
G
K
F
-------
T
S
-
G
P
Y
-----
L
E
Q
F
E
K
V
L
S
T
Y
L
----
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
--------
G
L
N
P
G
-
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
---
Y
---
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
G
L
T
----
D
L
G
K
Y
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
---------
V
N
V
--------
K
N
-
K
K
V
I
-
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
--
N
N
F
K
R
L
F
L
A
D
R
Y
--
I
T
Q
L
A
E
L
Q
N
K
G
Y
I
--
E
L
P
E
L
S
E
--
D
-
H
V
W
H
L
F
P
I
K
V
---------------------
R
T
---------------
E
---------
D
-----
R
A
D
I
M
T
K
L
N
E
D
F
-
G
V
---
Q
T
--
D
V
Y
Y
-
P
-
I
L
S
H
M
Q
K
-
T
P
-
L
V
Q
--
D
K
-
Y
------------
A
G
L
-
Q
L
V
H
T
--
E
K
A
H
S
Q
V
--
L
H
L
P
L
Y
P
S
F
-
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
-----
2
PsiBlast_PDB
87.04
33%
-102
- C1 -
1MDZ
1
ARNB_SALTY
A:
[11-379]
--------------------------------------------------------------------
L
P
F
-
S
R
-----
P
A
-
M
G
--
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-----------------
T
G
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
--------
G
I
G
E
G
-
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
---
Q
---
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
-
T
A
I
F
S
F
H
A
I
K
N
I
T
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
----
D
----------------
Q
A
E
V
L
-
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
--
L
N
A
R
R
A
A
I
A
A
Q
Y
--
H
Q
A
M
A
D
L
-
P
F
Q
P
L
--
S
L
P
S
W
E
H
--
I
-
H
A
W
H
L
F
I
I
R
V
---------------------
D
E
----
A
----------
R
CGI------
T
-----
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
---
G
T
--
G
L
H
F
-
R
-
A
-
A
H
T
Q
K
Y
Y
R
E
R
F
P
--
T
L
-
T
------------
L
P
D
-----
T
--
E
W
N
S
E
R
I
--
C
S
L
P
L
F
P
D
M
-
T
E
S
D
F
D
R
V
I
T
A
L
---------
6
PsiBlast_PDB
86.50
31%
-101
- C1 -
4LC3
10
?
A:
[17-379]
--------------------------------------------------------------------
L
P
F
-
T
R
-----
P
E
-
I
D
--
E
E
T
I
Q
G
V
V
E
V
L
R
S
G
W
I
T
-------
T
-
G
P
Q
-----
C
Q
K
F
E
A
A
L
S
E
Y
C
----
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
I
A
--------
G
V
G
P
G
-
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
E
Q
A
I
T
P
---
R
---
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
H
A
N
K
N
L
T
T
-
I
E
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
R
----
T
G
F
-------------
D
G
M
D
C
D
-
V
L
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
Q
L
P
H
L
E
R
--
F
T
A
Q
R
R
A
L
A
R
A
Y
F
A
A
F
D
G
G
A
A
A
K
L
G
-
V
--
G
L
P
-
V
A
E
F
E
N
-
G
N
W
H
M
F
L
V
T
L
PLE------------------
R
L
----
T
----------
I
---------
T
-----
R
A
E
F
M
A
Q
M
K
E
-
R
-
G
I
---
G
T
--
G
I
H
Y
-
P
-
A
-
I
H
L
F
T
-
L
Y
R
A
R
G
--
F
K
-
E
------------
G
M
F
-
P
H
--
A
--
E
R
Y
G
A
S
T
--
V
T
L
P
L
F
T
Q
M
-
T
E
G
D
V
R
R
V
V
------------
32
HHSearch
86.35
31%
-101
- C1 -
3BB8
3
?
A:
[35-433]
---------------------------------------------------------------------
P
P
-
S
G
-----
K
V
-
I
G
--
T
K
E
L
Q
L
M
V
E
A
S
L
D
G
W
L
-------
T
T
-
G
R
F
-----
N
D
A
F
E
K
K
L
G
E
Y
L
----
G
V
P
Y
V
L
T
T
T
S
G
S
S
A
N
L
L
A
L
T
A
L
T
SPKLGVR
A
L
K
P
G
-
D
E
V
I
T
V
A
A
G
F
P
T
T
V
N
P
T
I
Q
N
G
L
I
P
V
F
V
D
V
D
I
P
T
Y
N
V
N
A
S
L
I
E
A
A
V
S
D
---
K
---
T
K
A
I
M
I
A
H
T
L
G
N
L
F
D
L
A
E
V
R
R
V
A
D
K
Y
N
L
W
L
I
E
D
C
C
D
A
L
G
S
T
Y
D
G
K
M
A
G
T
F
G
D
I
G
T
V
S
F
Y
P
A
K
H
I
-
T
M
G
E
G
G
A
V
F
T
Q
S
A
E
L
K
S
I
I
E
S
F
R
D
W
G
R
D
C
----------
Q
LGSLPFGY
D
H
K
Y
T
Y
S
-
H
L
G
Y
N
L
K
I
T
D
M
Q
A
A
C
G
L
A
Q
L
E
R
I
E
E
--
F
V
E
K
R
K
A
N
F
K
Y
L
--
K
D
A
L
Q
S
C
--
A
D
F
I
--
E
L
P
E
A
T
E
N
S
D
-
P
S
W
F
G
F
P
I
T
L
---------------------
K
E
----
D
----------
S
GV-------
S
-----
R
I
D
L
V
K
F
L
D
E
-
A
-
K
V
---
G
T
--
R
L
L
F
A
G
-
N
-
L
T
R
Q
P
-
Y
F
H
D
V
K
--
Y
R
V
V
------------
G
E
L
-
T
N
--
T
--
D
R
I
M
N
Q
T
--
F
W
I
G
I
Y
P
G
L
-
T
H
D
H
L
D
Y
V
V
S
K
F
E
E
F
F
-----
28
HHSearch
84.38
29%
-103
- C1 -
2C81
1
GLDSA_BACCI
A:
[8-411]
-----------------------------------------------------------------------W
P
E
-----
W
P
Q
H
S
--
D
R
T
R
R
K
I
E
E
V
F
Q
S
N
R
W
A
ISGYWT
G
E
-
E
S
M
-----
E
R
K
F
A
K
A
F
A
D
F
N
----
G
V
P
Y
C
V
P
T
T
S
G
S
T
A
L
M
L
A
L
E
A
L
--------
G
I
G
E
G
-
D
E
V
I
V
P
S
L
T
W
I
A
T
A
T
A
V
L
N
V
N
A
L
P
V
F
V
D
V
E
A
D
T
Y
C
I
D
P
Q
L
I
K
S
A
I
T
D
---
K
---
T
K
A
I
I
P
V
H
L
F
G
S
M
A
N
M
D
E
I
N
E
I
A
Q
E
H
N
L
F
V
I
E
D
C
A
Q
S
H
G
S
V
W
N
N
Q
R
A
G
T
I
G
D
I
G
A
F
S
C
Q
Q
G
K
V
L
T
-
A
G
E
G
G
I
I
V
T
K
N
P
R
L
F
E
L
I
Q
Q
L
R
A
D
S
R
V
Y
CDDS
S
E
L
M
H
G
D
--------
M
Q
L
V
K
K
G
D
I
Q
G
S
N
Y
C
L
S
E
F
Q
S
A
I
L
L
D
Q
L
Q
E
L
D
D
--
K
N
A
I
R
E
K
N
A
M
F
L
--
N
D
A
L
S
K
I
--
D
G
-
I
--
K
V
M
K
R
P
P
Q
V
S
R
Q
T
Y
Y
G
Y
V
F
R
F
---------------------
D
P
VKFG
G
----------
L
---------
N
-----
A
D
Q
F
C
E
I
L
R
E
-
K
L
N
M
GTF
Y
L
--
H
P
P
Y
-
L
-
P
-
V
H
K
N
P
-
L
F
C
P
W
T
KN
R
Y
-
L
KSVRKT
E
A
Y
W
R
G
L
H
Y
-
P
V
--
S
--
E
R
A
S
G
Q
S
--
I
V
I
H
H
A
I
L
L
A
E
P
S
H
L
S
L
L
V
D
A
V
A
E
L
A
-----
41
HHSearch
84.23
26%
-106
- C1 -
2PO3
2
?
A:
[22-383]
---------------------------------------------------------------------
L
V
-
G
R
-----
P
N
-
R
I
D
R
A
R
L
Y
E
R
L
D
R
A
L
D
S
Q
W
L
-------
S
N
G
G
P
L
-----
V
R
E
F
E
E
R
V
A
G
L
A
----
G
V
R
H
A
V
A
T
C
N
A
T
A
G
L
Q
L
L
A
H
A
A
--------
G
L
-
T
G
--
E
V
I
M
P
S
M
T
F
A
A
T
P
H
A
L
R
W
I
G
L
T
P
V
F
A
D
I
D
P
D
T
G
N
L
D
P
D
Q
V
A
A
A
V
T
P
---
R
---
T
S
A
V
V
G
V
H
L
W
G
R
P
C
A
A
D
Q
L
R
K
V
A
D
E
H
G
L
R
L
Y
F
D
A
A
H
A
L
G
C
A
V
D
G
R
P
A
G
S
L
G
D
A
E
V
F
S
F
H
A
T
K
A
V
N
A
F
-
E
G
G
A
V
V
T
D
D
A
D
L
A
A
R
I
R
A
L
H
N
F
G
F
D
---------------------
L
P
G
G
S
P
-
A
G
G
T
N
A
K
M
S
E
A
A
A
A
M
G
L
T
S
L
D
A
F
P
E
--
V
I
D
R
N
R
R
N
H
A
A
Y
--
R
E
H
L
A
D
L
---
P
G
V
--
L
V
A
D
H
D
R
H
G
L
-
N
N
H
Q
Y
V
I
V
E
I
---------------------
D
E
----
A
TTG-------
I
---------
H
-----
R
D
L
V
M
E
V
L
K
A
-
E
-
G
V
---
H
T
--
R
A
Y
F
-
S
-
P
G
C
H
E
L
E
-
P
Y
R
G
-------
Q
------------
P
H
A
-
P
L
P
H
T
--
E
R
L
A
A
R
V
--
L
S
L
P
T
G
T
A
I
-
G
D
D
D
I
R
R
V
A
D
L
L
R
L
C
A
-----
12
Fugue
84.10
28%
-115
- C1 -
4K2M
7
NTDA_BACSU
A:
[1-442]
AG
M
Q
K
Q
V
K
ISGK
S
K
E
N
M
S
L
L
K
H
L
K
GDVQGKELVIEDSIVN
E
R
W
K
Q
V
L
KEKIDIEHDLFNYQKNREIS
K
V
P
F
-
L
P
-----
V
D
-
R
L
--
I
T
N
D
E
V
E
D
I
L
N
T
L
T
E
V
L
------
P
T
-
G
K
F
TSG
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
----
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
--------
G
L
N
P
G
-
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
---
Y
---
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
G
L
T
D
----
L
G
K
Y
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
V
C
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
----
N
V
K
N
K
K
V
--------
I
N
F
-------
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
--
N
N
F
K
R
L
F
L
A
D
R
Y
--
I
T
Q
L
A
E
L
Q
N
K
G
Y
I
--
E
L
P
E
L
S
E
D
H
V
-
W
--
H
L
F
P
I
K
V
---------------------
R
T
----
E
----------
D
---------
R
-----
A
D
I
M
T
K
L
N
E
D
-
F
-
G
V
---
Q
T
--
D
V
Y
Y
P
I
-
L
-
S
H
M
Q
K
-
T
P
L
V
Q
D
--
K
Y
-
A
------------
G
L
Q
L
V
H
--
T
--
E
K
A
H
S
Q
V
--
L
H
L
P
L
Y
P
S
F
-
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
I
G
37
HHSearch
83.33
30%
-104
- C1 -
3NYT
1
WBPE_PSEAE
A:
[1-359]
-------------------------------------------------------------------
M
I
E
F
-
I
D
L
K
N
Q
Q
A
R
-
I
K
--
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
Y
-------
I
L
-
G
P
E
-----
V
T
E
L
E
D
R
L
A
D
F
V
----
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
--------
G
V
G
P
G
-
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
E
A
A
I
T
P
---
R
---
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
Y
G
I
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
F
P
S
A
P
L
G
C
Y
G
D
G
G
A
I
F
T
N
D
D
E
L
A
T
A
I
R
Q
I
A
R
H
G
Q
D
---------------------
R
R
Y
H
H
I
-
R
V
G
V
N
S
R
L
D
T
L
Q
A
A
I
L
L
P
K
L
E
I
F
E
E
--
E
I
A
L
R
Q
K
V
A
A
E
Y
--
D
L
S
L
K
Q
V
---
G
-
I
--
G
T
P
F
I
E
V
N
N
I
-
S
V
Y
A
Q
Y
T
V
R
M
--------------------------------------
D
---------
N
-----
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
---
P
T
--
A
V
H
Y
P
I
-
P
-
L
N
K
Q
P
-
A
V
A
D
E
------
K
------------
A
K
L
-
P
V
--
G
--
D
K
A
A
T
Q
V
--
M
S
L
P
M
H
P
Y
L
-
D
T
A
S
I
K
I
I
C
A
A
L
T
N
-------
31
HHSearch
83.29
30%
-108
- C1 -
3FRK
2
?
A:
[13-365]
-------------------------------------------------------------------------------
D
E
-
I
E
--
Y
E
I
K
F
K
F
E
E
I
Y
K
R
N
W
F
I
-------
L
-
G
D
E
-----
D
K
K
F
E
Q
E
F
A
D
Y
C
----
N
V
N
Y
C
I
G
C
G
N
G
L
D
A
L
H
L
I
L
K
G
Y
--------
D
I
G
F
G
-
D
E
V
I
V
P
S
N
T
F
I
A
T
A
L
A
V
S
Y
T
G
A
K
P
I
F
V
E
P
D
I
R
T
Y
N
I
D
P
S
L
I
E
S
A
I
T
E
---
K
---
T
K
A
I
I
A
V
H
L
Y
G
Q
P
A
D
M
D
E
I
K
R
I
A
K
K
Y
N
L
K
L
I
E
D
A
A
Q
A
H
G
S
L
Y
K
G
M
K
V
G
S
L
G
D
A
A
G
F
S
F
Y
P
A
K
N
L
G
S
L
G
D
G
G
A
V
V
T
N
D
K
D
L
A
E
K
I
K
A
L
S
N
Y
G
S
E
---------------------
K
K
Y
H
H
I
-
Y
K
G
F
N
S
R
L
D
E
L
Q
A
G
F
L
R
V
K
L
K
Y
L
D
K
--
W
N
E
E
R
R
K
I
A
Q
K
Y
--
I
A
G
I
N
N
P
---
N
-
V
--
I
I
P
V
E
A
D
Y
A
K
-
H
V
W
Y
T
F
V
I
R
S
---------------------
E
--------------------------
K
-----
R
D
E
L
Q
K
Y
L
N
N
-
N
-
G
I
---
G
T
--
L
I
H
Y
-
P
I
P
-
I
H
L
Q
Q
-
A
Y
K
D
L
G
--
F
K
-
T
------------
G
N
F
-
P
I
--
A
--
E
K
I
A
N
E
I
--
L
S
I
P
I
W
Y
G
M
-
K
N
E
E
I
E
Y
V
I
D
K
I
N
A
W
K
-----
39
HHSearch
82.64
26%
-112
- C1 -
3UWC
3
?
A:
[14-368]
------------------------------------------------------------------------
Q
F
-----
A
D
-
I
E
---
P
Y
L
N
D
L
R
E
F
I
K
T
A
D
F
-------
T
L
-
G
A
E
-----
L
E
K
F
E
K
R
F
A
A
L
H
----
N
A
P
H
A
I
G
V
G
T
G
T
D
A
L
A
M
S
F
K
M
L
--------
N
I
G
A
G
-
D
E
V
I
T
C
A
N
T
F
I
A
S
V
G
A
I
V
Q
A
G
A
T
P
V
L
V
D
S
E
N
-
G
Y
V
I
D
P
E
K
I
E
A
A
I
T
D
---
K
---
T
K
A
I
M
P
V
H
Y
T
G
N
I
A
D
M
P
A
L
A
K
I
A
K
K
H
N
L
H
I
V
E
D
A
C
Q
T
I
L
G
R
I
N
D
K
F
V
G
S
W
G
Q
F
A
C
F
S
L
H
P
L
K
N
L
N
V
W
S
D
A
G
V
I
I
T
H
S
D
E
Y
A
E
K
L
R
L
Y
R
N
H
G
L
I
---------------------
N
R
D
V
C
V
-
E
Y
G
I
N
C
R
M
D
T
I
Q
A
V
I
A
N
R
L
M
N
Q
L
E
T
--
I
T
E
K
R
R
G
I
A
H
L
Y
--
D
Q
S
F
V
D
L
S
--
E
F
I
--
D
V
P
V
R
R
E
G
V
Y
-
H
V
F
H
I
Y
V
L
R
V
---------------------
K
--------------------------
Y
-----
R
D
Q
L
F
Q
Y
L
K
D
-
N
-
G
I
---
E
V
--
K
I
H
Y
P
I
-
A
-
M
H
L
Q
P
-
A
A
K
S
L
G
--
Y
Q
-
Q
------------
G
D
F
-
P
M
--
A
--
E
K
H
G
E
A
V
--
I
T
L
P
A
H
P
Y
L
-
T
E
E
E
I
N
Y
I
I
K
K
V
R
E
F
Y
-----
8
Fugue
82.58
25%
-111
- C1 -
1O69
3
?
A:
[12-385]
--------------------------------------------------------------------------------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
A
------
P
L
-
G
E
F
-----
V
N
R
F
E
Q
S
V
K
D
Y
S
----
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
--------
G
V
K
Q
D
-
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
-
D
E
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
CEK
K
---
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
T
S
G
-
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
R
E
N
----
C
L
---------------
H
Y
E
H
L
-
D
Y
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
--
R
V
L
K
K
R
E
I
Y
E
W
Y
--
K
E
F
L
G
E
Y
-----
F
--
S
F
L
D
E
L
E
N
S
R
-
S
N
R
W
L
S
T
A
L
I
NFDKNELNA
C
Q
K
D
I
N
I
S
Q
K
N
I
T
L
----
H
----------
P
---------
K
-----
I
S
K
L
I
E
D
L
K
N
-
K
-
Q
I
---
E
T
--
R
P
L
W
-
K
-
A
-
M
H
T
Q
E
-
V
F
K
--
G
--
A
K
-
A
------------
Y
L
N
-
G
N
--
S
--
E
L
F
F
Q
K
G
--
I
C
L
P
S
G
T
A
M
-
S
K
D
D
V
Y
E
I
S
K
L
I
L
K
S
I
K
----
38
HHSearch
82.01
24%
-111
- C1 -
2FNU
4
PSEC_HELPY
A:
[3-369]
-------------------------------------------------------------------
E
F
A
Y
-
S
E
-----
P
C
-
L
D
--
K
E
D
K
K
A
V
L
E
V
L
N
S
K
Q
L
T
-------
Q
-
G
K
R
-----
S
L
L
F
E
E
A
L
C
E
F
L
----
G
V
K
H
A
L
V
F
N
S
A
T
S
A
L
L
T
L
Y
R
N
F
S-------
E
F
S
A
D
R
N
E
I
I
T
T
P
I
S
F
V
A
T
A
N
M
L
L
E
S
G
Y
T
P
V
F
A
G
I
K
N
D
G
-
N
I
D
E
L
A
L
E
K
L
I
N
E
---
R
---
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
----
K
D
F
F
E
-------------
G
E
V
K
-
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
--
L
M
Q
K
R
E
E
A
A
L
T
Y
--
D
R
I
F
K
D
N
---
P
Y
F
--
T
P
L
H
P
L
L
K
D
K
-
S
S
N
H
L
Y
P
I
L
M
---------------------
H
Q
----
K
FF--------
T
---------
C
-----
K
K
L
I
L
E
S
L
H
K
-
R
-
G
I
---
L
A
--
Q
V
H
Y
-
K
-
P
-
I
Y
Q
Y
Q
-
L
Y
Q
Q
L
------
F
------------
N
T
A
-
P
L
--
K
S
A
E
D
F
Y
H
A
E
--
I
S
L
P
C
H
A
N
L
-
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
F
-----
3
PsiBlast_PDB
81.84
31%
-107
- C1 -
3DR4
2
?
A:
[28-386]
---------------------------------------------------------------------
S
V
-
A
A
-----
P
R
-
L
D
--
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
S
------
S
V
-
G
R
F
-----
I
V
E
F
E
K
A
F
A
D
Y
C
----
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
--------
G
I
G
P
G
-
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
---
R
---
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
T
-
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
----
N
R
---------------
R
Y
W
F
P
-
I
V
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
--
Y
--
E
Q
K
L
A
R
L
G
N
--
R
V
--
T
K
P
H
V
---
A
L
-
T
G
R
H
V
F
W
M
Y
T
---------------------
V
R
----
L
----------
G
---------
E
GLSTT
R
D
Q
V
I
K
D
L
D
A
-
L
-
G
I
---
E
S
R
P
V
F
H
----
P
-
M
H
I
M
P
-
P
Y
A
H
L
-------------------
A
T
D
-
D
L
--
K
--
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
-
T
E
A
D
I
D
R
V
I
A
A
L
---------
33
HHSearch
79.03
24%
-109
- C1 -
1O69
3
?
A:
[12-384]
--------------------------------------------------------------------------------------
G
N
E
L
K
Y
I
E
E
V
F
K
S
N
Y
I
A
------
P
L
-
G
E
F
-----
V
N
R
F
E
Q
S
V
K
D
Y
S
----
K
S
E
N
A
L
A
L
N
S
A
T
A
A
L
H
L
A
L
R
V
A
--------
G
V
K
Q
D
-
D
I
V
L
A
S
S
F
T
F
I
A
S
V
A
P
I
C
Y
L
K
A
K
P
V
F
I
D
C
D
-
E
T
Y
N
I
D
V
D
L
L
K
L
A
I
K
E
---
C
EKK
P
K
A
L
I
L
T
H
L
Y
G
N
A
A
K
M
D
E
I
V
E
I
C
K
E
N
D
I
V
L
I
E
D
A
A
E
A
L
G
S
F
Y
K
N
K
A
L
G
T
F
G
E
F
G
V
Y
S
Y
N
G
N
K
I
I
T
-
T
S
G
G
G
M
L
I
G
K
N
K
E
K
I
E
K
A
R
F
Y
S
T
Q
A
R
E
N
----
C
---------------
L
H
Y
E
H
L
-
D
Y
G
Y
N
Y
R
L
S
N
V
L
G
A
I
G
V
A
Q
M
E
V
L
E
Q
--
R
V
L
K
K
R
E
I
Y
E
W
Y
--
K
E
F
L
G
E
Y
-----
F
--
S
F
L
D
E
L
E
N
S
R
-
S
N
R
W
L
S
T
A
L
I
---------------------
N
F
DK--
N
ELNA
C
Q
K
D
I
N
I
S
Q
K
N
I
T
L
H
P
K
-----
I
S
K
L
I
E
D
L
K
N
-
K
-
Q
I
---
E
T
--
R
P
L
W
-
K
-
A
-
M
H
T
Q
E
-
V
F
K
G
A
K
--
A
---------------
Y
L
N
-
G
N
--
S
--
E
L
F
F
Q
K
G
--
I
C
L
P
S
G
T
A
M
-
S
K
D
D
V
Y
E
I
S
K
L
I
L
K
S
I
-----
User Run . : Multi Template Modeling Result:
(5 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIPFNAPPVVG
T
E
L
D
Y
M
Q
S
A
MGSGKLCGDGG
F
T
R
R
C
Q
Q
W
L
E
Q
RFGS
A
K
V
L
LTPSCT
A
S
L
E
M
A
A
L
L
L
DIQPGD
E
V
I
MP
S
Y
T
F
V
STA
N
A
F
V
LRG
A
K
I
V
F
V
DVRPDTM
N
I
D
E
T
L
I
E
A
AITDK
T
R
V
I
V
P
V
HYAGVA
C
E
M
D
T
I
M
A
L
A
KKH
N
L
F
V
V
E
D
A
A
Q
G
V
M
S
T
YKGRALGTIG
H
I
G
C
F
S
F
HETKNYTAGGEG
G
A
T
L
IN
D
K
A
L
I
E
R
A
E
I
I
R
EKGT
N
R
S
Q
F
FRGQVDK
Y
T
W
R
D
I
G
S
S
Y
L
M
S
D
L
Q
A
A
Y
L
W
A
Q
L
E
A
A
D
R
I
N
Q
Q
R
L
A
L
W
Q
N
Y
Y
D
A
L
A
P
L
A
KAGRIELPSI
P
D
G
C
VQN
A
H
M
F
Y
I
K
L
RDID
D
R
S
A
L
I
N
F
L
K
E
A
E
I
M
A
V
F
H
YIPLHGCP
A
G
E
H
F
G
E
FHGEDRYT
T
K
E
S
E
R
L
L
RL
P
L
F
YNLSPVN
Q
R
T
V
I
A
T
L
L
N
YFS
57
99.96
100%
-122
- C- -
M057
-
A:
[1-454]
M
I
P
F
N
A
P
P
V
V
G
T
E
L
D
Y
M
Q
S
A
M
G
S
G
K
L
C
G
D
G
G
F
T
R
R
C
Q
Q
W
L
E
Q
R
F
G
S
A
K
V
L
L
T
P
S
C
T
A
S
L
E
M
A
A
L
L
L
D
I
Q
P
G
D
E
V
I
M
P
S
Y
T
F
V
S
T
A
N
A
F
V
L
R
G
A
K
I
V
F
V
D
V
R
P
D
T
M
N
I
D
E
T
L
I
E
A
A
I
T
D
K
T
R
V
I
V
P
V
H
Y
A
G
V
A
C
E
M
D
T
I
M
A
L
A
K
K
H
N
L
F
V
V
E
D
A
A
Q
G
V
M
S
T
Y
K
G
R
A
L
G
T
I
G
H
I
G
C
F
S
F
H
E
T
K
N
Y
T
A
G
G
E
G
G
A
T
L
I
N
D
K
A
L
I
E
R
A
E
I
I
R
E
K
G
T
N
R
S
Q
F
F
R
G
Q
V
D
K
Y
T
W
R
D
I
G
S
S
Y
L
M
S
D
L
Q
A
A
Y
L
W
A
Q
L
E
A
A
D
R
I
N
Q
Q
R
L
A
L
W
Q
N
Y
Y
D
A
L
A
P
L
A
K
A
G
R
I
E
L
P
S
I
P
D
G
C
V
Q
N
A
H
M
F
Y
I
K
L
R
D
I
D
D
R
S
A
L
I
N
F
L
K
E
A
E
I
M
A
V
F
H
Y
I
P
L
H
G
C
P
A
G
E
H
F
G
E
F
H
G
E
D
R
Y
T
T
K
E
S
E
R
L
L
R
L
P
L
F
Y
N
L
S
P
V
N
Q
R
T
V
I
A
T
L
L
N
Y
F
S
58
99.62
100%
-127
- C- -
M058
-
A:
[1-460]
M
I
P
F
N
A
P
P
V
V
G
T
E
L
D
Y
M
Q
S
A
M
G
S
G
K
L
C
G
D
G
G
F
T
R
R
C
Q
Q
W
L
E
Q
R
F
G
S
A
K
V
L
L
T
P
S
C
T
A
S
L
E
M
A
A
L
L
L
D
I
Q
P
G
D
E
V
I
M
P
S
Y
T
F
V
S
T
A
N
A
F
V
L
R
G
A
K
I
V
F
V
D
V
R
P
D
T
M
N
I
D
E
T
L
I
E
A
A
I
T
D
K
T
R
V
I
V
P
V
H
Y
A
G
V
A
C
E
M
D
T
I
M
A
L
A
K
K
H
N
L
F
V
V
E
D
A
A
Q
G
V
M
S
T
Y
K
G
R
A
L
G
T
I
G
H
I
G
C
F
S
F
H
E
T
K
N
Y
T
A
G
G
E
G
G
A
T
L
I
N
D
K
A
L
I
E
R
A
E
I
I
R
E
K
G
T
N
R
S
Q
F
F
R
G
Q
V
D
K
Y
T
W
R
D
I
G
S
S
Y
L
M
S
D
L
Q
A
A
Y
L
W
A
Q
L
E
A
A
D
R
I
N
Q
Q
R
L
A
L
W
Q
N
Y
Y
D
A
L
A
P
L
A
K
A
G
R
I
E
L
P
S
I
P
D
G
C
V
Q
N
A
H
M
F
Y
I
K
L
R
D
I
D
D
R
S
A
L
I
N
F
L
K
E
A
E
I
M
A
V
F
H
Y
I
P
L
H
G
C
P
A
G
E
H
F
G
E
F
H
G
E
D
R
Y
T
T
K
E
S
E
R
L
L
R
L
P
L
F
Y
N
L
S
P
V
N
Q
R
T
V
I
A
T
L
L
N
Y
F
S
61
99.11
100%
-130
- C- -
M061
-
A:
[1-460]
M
I
P
F
N
A
P
P
V
V
G
T
E
L
D
Y
M
Q
S
A
M
G
S
G
K
L
C
G
D
G
G
F
T
R
R
C
Q
Q
W
L
E
Q
R
F
G
S
A
K
V
L
L
T
P
S
C
T
A
S
L
E
M
A
A
L
L
L
D
I
Q
P
G
D
E
V
I
M
P
S
Y
T
F
V
S
T
A
N
A
F
V
L
R
G
A
K
I
V
F
V
D
V
R
P
D
T
M
N
I
D
E
T
L
I
E
A
A
I
T
D
K
T
R
V
I
V
P
V
H
Y
A
G
V
A
C
E
M
D
T
I
M
A
L
A
K
K
H
N
L
F
V
V
E
D
A
A
Q
G
V
M
S
T
Y
K
G
R
A
L
G
T
I
G
H
I
G
C
F
S
F
H
E
T
K
N
Y
T
A
G
G
E
G
G
A
T
L
I
N
D
K
A
L
I
E
R
A
E
I
I
R
E
K
G
T
N
R
S
Q
F
F
R
G
Q
V
D
K
Y
T
W
R
D
I
G
S
S
Y
L
M
S
D
L
Q
A
A
Y
L
W
A
Q
L
E
A
A
D
R
I
N
Q
Q
R
L
A
L
W
Q
N
Y
Y
D
A
L
A
P
L
A
K
A
G
R
I
E
L
P
S
I
P
D
G
C
V
Q
N
A
H
M
F
Y
I
K
L
R
D
I
D
D
R
S
A
L
I
N
F
L
K
E
A
E
I
M
A
V
F
H
Y
I
P
L
H
G
C
P
A
G
E
H
F
G
E
F
H
G
E
D
R
Y
T
T
K
E
S
E
R
L
L
R
L
P
L
F
Y
N
L
S
P
V
N
Q
R
T
V
I
A
T
L
L
N
Y
F
S
63
97.22
100%
-120
- C- -
M063
-
A:
[1-460]
M
I
P
F
N
A
P
P
V
V
G
T
E
L
D
Y
M
Q
S
A
M
G
S
G
K
L
C
G
D
G
G
F
T
R
R
C
Q
Q
W
L
E
Q
R
F
G
S
A
K
V
L
L
T
P
S
C
T
A
S
L
E
M
A
A
L
L
L
D
I
Q
P
G
D
E
V
I
M
P
S
Y
T
F
V
S
T
A
N
A
F
V
L
R
G
A
K
I
V
F
V
D
V
R
P
D
T
M
N
I
D
E
T
L
I
E
A
A
I
T
D
K
T
R
V
I
V
P
V
H
Y
A
G
V
A
C
E
M
D
T
I
M
A
L
A
K
K
H
N
L
F
V
V
E
D
A
A
Q
G
V
M
S
T
Y
K
G
R
A
L
G
T
I
G
H
I
G
C
F
S
F
H
E
T
K
N
Y
T
A
G
G
E
G
G
A
T
L
I
N
D
K
A
L
I
E
R
A
E
I
I
R
E
K
G
T
N
R
S
Q
F
F
R
G
Q
V
D
K
Y
T
W
R
D
I
G
S
S
Y
L
M
S
D
L
Q
A
A
Y
L
W
A
Q
L
E
A
A
D
R
I
N
Q
Q
R
L
A
L
W
Q
N
Y
Y
D
A
L
A
P
L
A
K
A
G
R
I
E
L
P
S
I
P
D
G
C
V
Q
N
A
H
M
F
Y
I
K
L
R
D
I
D
D
R
S
A
L
I
N
F
L
K
E
A
E
I
M
A
V
F
H
Y
I
P
L
H
G
C
P
A
G
E
H
F
G
E
F
H
G
E
D
R
Y
T
T
K
E
S
E
R
L
L
R
L
P
L
F
Y
N
L
S
P
V
N
Q
R
T
V
I
A
T
L
L
N
Y
F
S
51
29.06
100%
-37
- C- -
M051
-
A:
[2-385]
M
I
P
F
N
A
P
P
V
V
G
T
E
L
D
Y
M
Q
S
A
M
G
S
G
K
L
C
G
D
G
G
F
T
R
R
C
Q
Q
W
L
E
Q
R
F
G
S
A
K
V
L
L
T
P
S
C
T
A
S
L
E
M
A
A
L
L
L
D
I
Q
P
G
D
E
V
I
M
P
S
Y
T
F
V
S
T
A
N
A
F
V
L
R
G
A
K
I
V
F
V
D
V
R
P
D
T
M
N
I
D
E
T
L
I
E
A
A
I
T
D
K
T
R
V
I
V
P
V
H
Y
A
G
V
A
C
E
M
D
T
I
M
A
L
A
K
K
H
N
L
F
V
V
E
D
A
A
Q
G
V
M
S
T
Y
K
G
R
A
L
G
T
I
G
H
I
G
C
F
S
F
H
E
T
K
N
Y
T
A
G
G
E
G
G
A
T
L
I
N
D
K
A
L
I
E
R
A
E
I
I
R
E
K
G
T
N
R
S
Q
F
F
R
G
Q
V
D
K
Y
T
W
R
D
I
G
S
S
Y
L
M
S
D
L
Q
A
A
Y
L
W
A
Q
L
E
A
A
D
R
I
N
Q
Q
R
L
A
L
W
Q
N
Y
Y
D
A
L
A
P
L
A
K
A
G
R
I
E
L
P
S
I
P
D
G
C
V
Q
N
A
H
M
F
Y
I
K
L
R
D
I
D
D
R
S
A
L
I
N
F
L
K
E
A
E
I
M
A
V
F
H
Y
I
P
L
H
G
C
P
A
G
E
H
F
G
E
F
H
G
E
D
R
Y
T
T
K
E
S
E
R
L
L
R
L
P
L
F
Y
N
L
S
P
V
N
Q
R
T
V
I
A
T
L
L
N
Y
F
S