@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TPC_HUMAN: (2015-12-12 )
MVGYDPKPDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCNVFHCMNRTASQR
Atome Classification :
(20 SA)
----------------------------------------------.........10.........20---------........30........40----........-.--50...--.....60---------........70..-......80..-------.----.....90........100....-----...110-...---..------....120.----.------.....130.......140.----......----.--------150-----------..----.....160.....--..170.......180......--.190...----------..-..200.---.....-------.210..---------------------.....--.220----.......230......----.240........250.......260-------------........270.......280.----......290--........300.......310.......320---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------MVGYDPKPDG-RNN
T
K
F
Q
V
A
VA---------G
S
V
S
G
L
V
T
R
A
LISPF
D
V
I
K
-----
I
R
F
Q
L
Q
H
E
-R--LSRSD--P
S
A
K
Y
H
G
---------
I
L
Q
A
S
R
Q
I
L
Q
EE-GPT
A
F
WKGHV-------
P
----
A
Q
I
L
S
I
G
Y
G
A
V
Q
F
L
S
F
E
M
L
T
E
L
-----
V
HRG---SVY---DA------
R
E
F
S
V
H
F
V----C------G
G
L
A
A
C
M
A
T
LTVH
P
V
D
V
-
L
----
R
T
R
FAA----Q--------GE
P
-----------
K
V
----
Y
N
T
L
R
H
A
V
G
T
M
YR--SEG
P
Q
V
F
Y
KGLAP
T
L
I
A
I
FPY--AGL
Q
F
S
C
----------
Y
S
-
S
L
K
H
L
Y
---
K
WAIP-------AE-GKK---------------------NE
N
L
Q
--
N
L
LC----GS
G
A
G
V
I
S
K
TLTY
P
L
D
----
L
F
K
-
K
R
L
QVGG
F
E
H
A
R
A
A
F
G
Q
V
R
R
--------------
Y
K
G
L
M
D
C
A
K
Q
V
L
Q
KEGAL
G
F
FK----GL
S
P
S
L
L
K
---
A
A
L
ST
G
F
M
F
F
S
Y
E
F
F
C
N
V
F
H
C
M
N
R
TASQR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.02
23%
-59
- C4 -
2C3E
4
ADT1_BOVIN
A:
[12-291]
------------------------------------------------------------------
L
A
---------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
-----
L
L
L
Q
V
Q
H
A
-
S
--
K
Q
I
S
---
A
E
K
Q
Y
K
G
---------
I
I
D
C
V
V
R
I
P
K
E
Q
-
G
F
L
S
F
W
R
G
N
L
-------
A
----
N
V
I
R
Y
F
P
T
Q
A
L
N
F
-
A
F
K
D
K
Y
K
Q
-----
I
F
L
G
---
G
V
D
---
R
H
------
K
Q
F
W
R
Y
F
A
G
N
L
A
S
------
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
-
A
----
R
T
R
L
A
A
----
D
VGKG----
A
A
Q
-----------
R
E
----
F
T
G
L
G
N
C
I
T
K
I
F
K
--
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
--
R
A
A
Y
F
G
V
----------
Y
D
-
T
A
K
G
M
-------
L
P
--------
D
-
P
K
N
---------------------
V
H
I
I
V
--
S
W
M
I
----
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
----
T
V
R
-
R
R
M
M
M
---
Q
S
G
R
K
--
G
A
D
I
M
--------------
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
----
G
A
W
S
N
V
L
R
----
G
M
G
G
A
F
V
L
V
L
Y
D
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.80
23%
-56
- C4 -
1OKC
10
ADT1_BOVIN
A:
[12-291]
------------------------------------------------------------------
L
A
---------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
-----
L
L
L
Q
V
Q
H
A
-
S
--
K
Q
I
S
---
A
E
K
Q
Y
K
G
---------
I
I
D
C
V
V
R
I
P
K
E
Q
-
G
F
L
S
F
W
R
G
N
L
-------
A
----
N
V
I
R
Y
F
P
T
Q
A
L
N
F
-
A
F
K
D
K
Y
K
Q
-----
I
F
L
G
---
G
V
D
---
R
H
------
K
Q
F
W
R
Y
F
A
G
N
L
A
S
------
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
-
A
----
R
T
R
L
A
A
----
D
VGKG----
A
A
Q
-----------
R
E
----
F
T
G
L
G
N
C
I
T
K
I
F
K
--
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
--
R
A
A
Y
F
G
V
----------
Y
D
-
T
A
K
G
M
-------
L
P
--------
D
-
P
K
N
---------------------
V
H
I
I
V
--
S
W
M
I
----
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
----
T
V
R
-
R
R
M
M
M
---
Q
S
G
R
K
--
G
A
D
I
M
--------------
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
----
G
A
W
S
N
V
L
R
----
G
M
G
G
A
F
V
L
V
L
Y
D
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
83.31
22%
-59
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------
D
-
Q
A
L
S
F
L
K
D
F
L
A
---------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
-----
L
L
L
Q
V
Q
H
A
-
S
--
K
Q
I
S
---
A
E
K
Q
Y
K
G
---------
I
I
D
C
V
V
R
I
P
K
E
Q
-
G
F
L
S
F
W
R
G
N
L
-------
A
----
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
-----
F
L
G
G
---
V
D
R
HKQ
F
W
------
R
Y
F
A
G
N
L
A
----
S
------
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
-
A
----
R
T
R
L
A
A
----
D
--------
V
G
K
GAAQ-------
R
E
----
F
T
G
L
G
N
C
I
T
K
I
F
K
--
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
--
R
A
A
Y
F
G
V
----------
Y
D
-
T
A
K
G
M
L
---
P
D
P
-------------
K
N
---------------------
V
H
I
I
V
--
S
W
M
I
----
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
----
T
V
R
-
R
R
M
M
M
Q
S
G
R
K
G
-----
A
D
I
M
--------------
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
----
G
A
W
S
N
V
L
R
---
G
M
G
-
G
A
F
V
L
V
L
Y
D
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Fugue
82.25
21%
-59
- C4 -
1OKC
10
ADT1_BOVIN
A:
[2-293]
-------------------------------------------------------
D
-
Q
A
L
S
F
L
K
D
F
L
A
---------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
V
K
-----
L
L
L
Q
V
Q
H
A
----
S
K
Q
I
S
--
A
E
K
Q
Y
K
G
---------
I
I
D
C
V
V
R
I
P
K
E
Q
-
G
F
L
S
F
W
R
G
N
L
-------
A
----
N
V
I
R
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
Y
K
Q
I
-----
F
L
G
G
VDR
H
K
Q
---
F
W
------
R
Y
F
A
G
N
L
A
----
S
------
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
F
-
A
----
R
T
R
L
A
A
----
D
--------
V
G
K
-----------
G
A
AQRE
F
T
G
L
G
N
C
I
T
K
I
F
K
--
S
D
G
L
R
G
L
Y
Q
G
F
N
V
S
V
Q
G
I
I
I
Y
--
R
A
A
Y
F
G
V
----------
Y
D
-
T
A
K
G
M
L
---
P
------------
D
-
P
K
N
---------------------
V
H
I
I
V
--
S
W
M
I
----
A
Q
T
V
T
A
V
A
G
L
V
S
Y
P
F
D
----
T
V
R
-
R
R
M
M
M
-----
Q
S
G
R
K
G
A
D
I
M
--------------
Y
T
G
T
V
D
C
W
R
K
I
A
K
D
E
G
P
K
A
F
F
K
----
G
A
W
S
N
V
L
R
---
G
M
G
G
A
F
V
L
V
L
Y
D
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.40
27%
-67
- C4 -
4C9H
5
ADT2_YEAST
A:
[30-302]
-----------------------------------------------------------------------------
G
G
V
S
A
A
V
A
K
T
A
A
S
P
I
E
R
V
K
-----
L
L
I
Q
N
Q
D
E
-
M
--
L
K
Q
G
T
--
L
D
R
K
Y
A
G
---------
I
L
D
C
F
K
R
T
A
T
Q
E
-
G
V
I
S
F
W
R
G
N
T
-------
A
----
N
V
I
R
---
Y
F
P
T
Q
A
L
N
F
A
F
K
D
K
I
K
A
M
F
G
F
K
K
E
---
E
G
Y
----
A
------
K
W
F
A
G
N
L
A
----
S
------
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
Y
-
A
----
R
T
R
L
A
A
DS-------------
A
-----------
R
Q
----
F
N
G
L
I
D
V
Y
K
K
T
L
K
--
S
D
G
V
A
G
L
Y
R
G
F
L
P
S
V
V
G
I
V
V
Y
--
R
G
L
Y
F
G
M
----------
Y
D
-
S
L
K
------------------------------------------------
L
A
--
S
F
L
L
----
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
----
T
V
R
-
R
R
M
M
M
--------
T
S
G
Q
A
V
K
--------------
Y
D
G
A
F
D
C
L
R
K
I
V
A
A
E
G
V
G
S
L
F
K
----
G
C
G
A
N
I
L
R
---
G
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.29
26%
-63
- C4 -
4C9J
4
ADT3_YEAST
A:
[34-306]
-----------------------------------------------------------------------------
G
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
-----
I
L
I
Q
N
Q
D
E
-
M
--
I
K
Q
G
T
--
L
D
K
K
Y
S
G
---------
I
V
D
C
F
K
R
T
A
K
Q
E
-
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
----
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
M
F
G
F
K
K
E
E
-----
G
Y
------------
G
------
K
W
F
A
G
N
L
A
----
S
------
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
-
A
----
R
T
R
L
A
A
DAKS-----------
A
-----------
R
Q
----
F
N
G
L
T
D
V
Y
K
K
T
L
K
--
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
--
R
G
L
Y
F
G
M
----------
F
D
-
S
L
K
-----------------------------------------------------
F
L
L
----
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
----
T
V
R
-
R
R
M
M
M
--------
T
S
G
Q
A
V
K
--------------
Y
N
G
A
I
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
----
G
C
G
A
N
I
L
R
---
S
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
K
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.78
26%
-62
- C4 -
4C9Q
5
ADT3_YEAST
A:
[34-306]
-----------------------------------------------------------------------------
G
G
V
S
A
A
I
A
K
T
A
A
S
P
I
E
R
V
K
-----
I
L
I
Q
N
Q
D
E
-
M
--
I
K
Q
G
T
--
L
D
K
K
Y
S
G
---------
I
V
D
C
F
K
R
T
A
K
Q
E
-
G
L
I
S
F
W
R
G
N
T
A
N
V
I
R
Y
F
P
----
T
Q
A
L
N
F
A
F
K
D
K
I
K
L
M
F
G
F
K
K
E
------
G
Y
------------
G
------
K
W
F
A
G
N
L
A
----
S
------
G
G
A
A
G
A
L
S
L
L
F
V
Y
S
L
D
F
-
A
----
R
T
R
L
A
A
DAKS-----------
A
-----------
R
Q
----
F
N
G
L
T
D
V
Y
K
K
T
L
K
--
S
D
G
I
A
G
L
Y
R
G
F
M
P
S
V
V
G
I
V
V
Y
--
R
G
L
Y
F
G
M
----------
F
D
-
S
L
K
P
L
---------------------------------------------
F
L
A
--
S
F
L
L
----
G
W
V
V
T
T
G
A
S
T
C
S
Y
P
L
D
----
T
V
R
-
R
R
M
M
M
--------
T
S
G
Q
A
V
K
--------------
Y
N
G
A
I
D
C
L
K
K
I
V
A
S
E
G
V
G
S
L
F
K
----
G
C
G
A
N
I
L
R
---
S
V
A
G
A
G
V
I
S
M
Y
D
Q
L
Q
M
I
L
F
G
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
75.13
23%
-67
- C4 -
2LCK
-
UCP2_MOUSE
A:
[14-302]
--------------------------------------------------------------
T
V
K
F
L
G
---------
A
G
T
A
A
C
I
A
D
L
I
T
F
P
L
D
T
A
K
-----
V
R
L
Q
I
Q
G
E
-
S
--
Q
G
L
V
R
T
A
A
S
A
Q
Y
R
G
---------
V
L
G
T
I
L
T
M
V
R
T
E
-
G
P
R
S
L
Y
N
G
L
V
-------
A
----
G
L
Q
R
Q
M
S
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
-----
Y
T
K
G
---
S
-----
E
H
------
A
G
I
G
S
R
L
L
----
A
------
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
V
-
V
----
K
V
R
F
Q
A
----
Q
--------
A
R
A
GGG--------
R
R
----
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
--
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
--
N
C
A
E
L
V
T
----------
Y
D
-
L
I
K
D
T
L
---
L
K
A
N
L
-----------
M
T
---------------------
D
D
L
P
C
--
H
F
T
S
----
A
F
G
A
G
F
C
T
T
V
I
A
S
P
V
D
----
V
V
K
-
T
R
Y
M
N
S
A
L
G
----------
Q
--------------
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
----
G
F
M
P
S
F
L
R
---
L
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
R
E
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
72.30
14%
-77
* C3 *
2I2X
-
MTAB_METBF
A:
[3-461]
-------AKRYTSMAYANADEMTFGVSK
Y
P
V
K
A
G
LDLEIGAG
Y
T
I
P
E
I
N
Y
A
P
R
P
E
A
G
A
S
K
E
K
L
I
K
E
Y
E
---------
R
I
T
T
D
V
M
E
R
M
V
Q
V
G
F
P
A
I
I
-----
L
E
T
E
H
V
Q
Q
-
M
--
S
N
N
P
S
--
W
G
A
E
V
A
H
---------
A
Q
K
T
I
M
E
K
Y
H
D
E
Y
G
I
K
C
A
L
R
H
T
I
-------
G
DIRE
N
R
E
F
L
Q
L
R
G
D
K
Y
S
V
F
L
E
A
F
E
Q
C
-----
A
E
N
G
---
A
D
L
---
L
S
V
ESMGG
K
E
V
F
D
Y
A
V
L
R
ND
I
------
P
G
L
L
Y
S
I
G
C
L
G
S
I
D
M
E
L
-
I
----
W
T
D
I
S
K
----
I
--------
A
K
K
T
GTIS
A
G
D
T
DC
A
Q
----
A
N
T
A
M
F
I
G
G
G
L
-
L
--
N
K
N
L
A
H
T
I
A
V
I
A
R
A
I
S
A
P
R
S
L
--
V
A
Y
E
A
G
A
VGPGKDCGYE
N
I
-
I
V
K
A
I
T
---
G
M
P
M
T
-------
M
E
-
G
K
T
STCAHSDVMGNLVMQCCDCWS
N
E
S
V
E
Y
H
G
E
F
G
----
G
T
T
V
Q
C
W
S
E
T
L
A
Y
D
C
A
----
L
M
N
-
T
A
L
E
T
K
N
D
K
V
L
R
D
L
M
M
L
S
D
R
--------------
Y
R
---
D
P
Q
A
Y
M
L
A
Y
D
N
A
Y
R
V
G
Q
----
S
I
V
K
D
---------
G
D
N
I
Y
L
R
A
K
N
A
A
I
E
C
C
N
I
I
E
E
G
A
A
G
K
LELS
R
F
E
T
K
A
L
A
D
A
K
A
A
L
E
A
LPDD
M
D
K
F
M
D
D
C
L
T
K
Y
K
S
E
V
KVFKPENYGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
68.91
17%
-74
- C3 -
2Y8V
-
?
A:
[8-287]
-----------------------------------------PEHR
R
V
I
C
Y
H
Q
T
L
C
P
-
N
R
G
D
Y
V
S
V
L
P
L
---------
V
K
N
N
T
G
V
T
H
I
I
I
A
A
F
H
L
N
E
--------
D
P
G
H
I
-
T
--
L
N
D
D
P
--
P
D
H
E
M
Y
N
---------
P
L
W
A
E
V
P
V
L
K
R
S
-
G
---------------------
V
K
V
M
G
M
L
G
G
A
A
Q
-
G
S
Y
R
C
L
D
G
-------------------
D
Q
------
E
K
F
E
R
Y
Y
------------
Q
P
L
L
A
M
V
R
R
H
Q
L
D
G
L
D
L
D
V
----
E
E
E
M
S
L
----
P
--------
G
I
I
-----------
R
L
----
I
D
R
L
K
L
D
L
G
----------
D
D
F
I
I
T
L
A
P
V
A
A
A
L
L
G
I
--
G
N
L
S
G
F
D
----------
Y
R
-
Q
L
E
Q
Q
R
---
G
S
K
I
-------------------------------------
S
W
Y
--
N
A
Q
F
----
Y
N
G
W
G
L
A
E
D
P
R
M
Y
A
A
I
----
V
A
Q
-------
G
W
S
P
Q
R
V
V
Y
G
L
L
T
N
--------------
P
G
N
G
S
Q
G
Y
V
P
R
E
R
I
G
P
V
L
A
V
L
V
----
E
Q
F
P
N
F
G
G
---
V
M
G
W
E
Y
F
N
S
I
P
G
E
Q
Q
S
P
W
Q
W
A
A
E
M
S
L
S
M
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
68.03
20%
-72
- C2 -
4TNW
-
?
A:
[1-342]
------------------------------------S
D
S
K
I
L
A
H
L
F
T
S
G
Y
D
F
R
V
---
R
P
P
T
D
N
G
G
P
V
V
---------
V
S
V
N
M
L
L
R
T
--
I
S
K
I
D
V
V
N
-----
M
E
Y
S
A
Q
L
T
L
R
--
E
S
W
I
D
--
K
R
L
S
Y
G
V
KGDGQPDFV
I
L
T
V
G
H
Q
I
W
M
----
P
D
T
F
F
P
N
E
K
-------
Q
----
A
Y
K
H
T
I
D
K
P
N
-------
V
L
I
R
I
-----
H
N
D
G
---
T
V
L
---
Y
S
------
V
R
I
S
L
V
L
S
----
C
------
P
------
M
Y
L
Q
Y
Y
P
M
D
V
-
Q
----
Q
C
S
I
D
L
----
A
--------
S
-------------------
Y
A
Y
T
T
K
D
I
E
Y
L
W
K
--
E
H
S
P
L
Q
L
K
V
G
L
S
S
S
L
P
S
F
Q
L
T
--
N
T
S
T
T
Y
C
----------
T
S
V
T
N
T
G
I
Y
S
C
L
R
T
T
I
Q
-------
L
K
-
R
E
F
---------------------
S
F
Y
L
L
--
Q
L
Y
I
----
P
S
C
M
L
V
I
V
S
W
V
S
F
W
F
D
RTA
I
P
A
R
-
V
T
L
G
V
T
T
L
L
T
M
T
A
Q
S
A
G
I
N
S
Q
LPPVSYIK
A
I
D
V
W
I
G
A
C
M
T
F
I
F
C
A
L
L
E
F
A
L
V
N
H
I
A
N
AGT
T
E
W
N
D
I
S
K
---
R
V
D
L
I
S
R
A
L
F
P
V
L
F
F
V
F
N
I
L
Y
W
S
R
F
G
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
64.65
26%
-63
- C4 -
2LCK
-
UCP2_MOUSE
A:
[33-292]
------------------------------------------------------------------------------------------
P
L
D
T
A
K
-----
V
R
L
Q
I
Q
G
E
-
S
QG
L
V
R
T
A
--
A
S
A
Q
Y
R
G
---------
V
L
G
T
I
L
T
M
V
R
T
E
-
G
P
R
S
L
Y
N
G
L
V
-------
A
----
G
L
Q
R
Q
M
S
F
A
S
V
R
I
G
L
Y
D
S
V
K
Q
F
-----
Y
T
K
G
---
S
E
H
---
A
G
--------
I
G
S
R
L
L
----
A
------
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
V
-
V
----
K
V
R
F
Q
A
----
Q
ARA-----
G
G
G
-----------
R
R
----
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
--
E
E
G
I
R
G
L
W
K
G
T
S
P
N
V
A
R
N
A
I
V
--
N
C
A
E
L
V
T
----------
Y
D
-
L
I
K
D
T
L
---
L
---------------
K
A
---------------------
N
L
M
T
D
--
D
L
P
C
H
F
T
S
A
F
G
A
G
F
C
T
T
V
I
A
S
P
V
D
----
V
V
K
-
T
R
-------
Y
M
N
S
A
L
G
Q
-----------------
Y
H
S
A
G
H
C
A
L
T
M
L
R
K
E
G
P
R
A
F
Y
K
----
G
F
M
P
S
F
L
R
---
L
G
S
W
N
V
V
M
F
V
T
Y
E
Q
L
K
R
A
L
M
A
A
Y
Q
S
R
E
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
61.75
11%
-79
* C5 *
4QYX
-
HSP31_YEAST
A:
[2-236]
----------------------------------------------------------
A
P
K
K
V
L
L
A
L
T
SYNDVFYSD
G
A
K
T
G
V
F
V
V
E
A
L
H
P
F
N
T
F
R
K
E
G
F
E
V
D
F
V
S
E
T
G
-
K
--
F
G
W
D
E
--
H
S
L
A
K
D
F
---------
L
N
G
Q
D
E
T
D
F
K
N
K
-
D
S
----------------------------------
D
F
N
K
T
L
A
K
-----
I
K
T
P
---
K
E
V
---
N
A
------
D
D
Y
Q
I
F
F
A
----
S
------
A
G
H
G
T
L
F
D
Y
P
K
A
K
D
L
Q
D
-
I
----
A
S
E
I
Y
A
----
N
--------
G
-------------
G
V
----
V
A
A
V
C
H
G
P
A
I
F
D
G
--
L
T
D
K
K
T
G
R
P
L
I
E
G
K
S
I
T
G
F
T
D
--
V
G
E
T
I
L
-----------------------
G
V
D
S
I
-------
L
K
-
A
K
N
---------------------
L
A
T
V
E
--
D
V
A
K
----
K
Y
G
A
-----
K
Y
L
A
P
V
G
----
P
W
D
-
D
Y
S
I
T
D
G
---------------------------------------------
R
L
V
T
----
G
V
N
P
A
S
A
H
---
S
T
A
V
R
S
I
V
A
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
60.00
23%
-60
- C4 -
1OKC
8
ADT1_BOVIN
A:
[6-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
L
K
D
F
L
----
A
------
G
G
V
A
A
A
I
S
K
T
A
V
A
P
I
E
R
-
V
----
K
L
L
L
Q
V
----
Q
--------
H
A
S
KQISAE-----
K
Q
----
Y
K
G
I
I
D
C
V
V
R
I
P
K
--
E
Q
G
F
L
S
F
W
R
G
N
L
A
N
V
I
R
Y
F
P
T
--
Q
A
L
N
F
A
F
----------
K
D
-
K
Y
K
Q
I
F
---
L
G
G
V
D
-------
R
H
K
Q
F
W
---------------------
R
Y
F
A
G
--
N
L
A
S
----
G
G
A
A
G
A
T
S
L
C
F
V
Y
P
L
D
----
F
A
R
-
T
R
L
A
A
D
V
G
K
G
A
-----
A
Q
R
E
--------------
F
T
G
L
G
N
C
I
T
K
I
F
K
S
D
G
L
R
G
L
Y
Q
----
G
F
N
V
S
V
Q
G
---
I
I
I
Y
R
A
A
Y
F
G
V
Y
D
T
A
K
G
M
L
P
D
P
K
N
V
H
I
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
59.01
13%
-70
- C3 -
2IVN
2
KAE1_PYRAB
A:
[1-325]
-------------------------------------------------------------
M
L
A
L
G
I
E
---------
G
T
A
H
T
L
G
I
G
I
V
S
E
D
K
V
L
A
N
-----
V
F
D
T
L
T
T
E
-
K
--
G
G
I
H
P
--
K
E
A
A
E
H
H
---------
A
R
L
M
K
P
L
L
R
K
A
L
-
S
E
A
G
V
S
L
D
D
I
-------
D
----
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
-
R
V
V
A
T
A
A
-----
R
A
L
A
---
V
K
Y
---
R
K
------
P
I
V
G
V
N
H
C
----
I
------
A
H
V
E
I
T
K
M
F
G
V
K
D
P
V
G
L
-
Y
V
S
GG
N
T
Q
V
L
A
----
L
E
GGRYRVF
G
E
T
LDIG
I
G
-----
N
A
----
I
D
V
F
A
R
E
L
G
L
G
F
---
P
G
G
P
K
V
E
K
L
A
E
K
G
E
K
Y
I
E
L
P
Y
AV
K
G
M
D
L
S
-----------
F
S
-
G
L
L
T
E
A
---
I
R
K
Y
R
-------
S
G
-
K
Y
R
---------------------
V
E
D
L
A
--
Y
S
F
Q
----
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
----
H
T
E
-
K
D
--------
E
V
V
L
V
G
G
V
A
A
--------------
N
N
R
L
R
E
M
L
R
I
M
T
E
D
R
G
I
K
F
F
V
------
P
P
Y
D
L
C
R
DN
G
A
M
I
A
Y
T
G
L
R
M
Y
K
A
G
I
S
F
R
L
E
E
T
I
V
K
Q
K
F
R
TDEVEIVWH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
56.36
29%
-57
- C4 -
2LCK
-
UCP2_MOUSE
A:
[15-208]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
F
L
----
G
------
A
G
T
A
A
C
I
A
D
L
I
T
F
P
L
D
T
-
A
----
K
V
R
L
Q
I
----
Q
--------
G
E
S
QG
L
V
R
T
A
AS--
A
Q
----
Y
R
G
V
L
G
T
I
L
T
M
V
R
--
T
E
G
P
R
S
L
Y
N
G
L
V
A
G
L
Q
R
Q
M
S
F
--
A
S
V
R
I
G
L
----------
Y
D
-
S
V
K
Q
F
Y
---
T
K
G
S
------------
E
H
---------------------
A
G
I
G
S
--
R
L
L
A
----
G
S
T
T
G
A
L
A
V
A
V
A
Q
P
T
D
----
V
V
K
-
V
R
F
Q
A
Q
A
R
A
G
G
------
G
R
R
--------------
Y
Q
S
T
V
E
A
Y
K
T
I
A
R
E
E
G
I
R
G
L
W
K
----
G
T
S
P
N
V
A
R
---
N
A
I
V
N
C
A
E
L
V
T
Y
D
L
I
K
D
T
L
L
K
A
N
L
M
T
D
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
50.23
10%
-60
- C3 -
4JAW
2
?
A:
[11-643]
SSGLVPRGSHMGYSATAPVNLTRPATVPSMDG
W
T
D
G
T
G
A
W
T
L
G
EGT
R
V
V
S
S
D
A
L
---
A
A
R
A
Q
S
L
A
S
E
L
---------
T
K
F
T
D
V
D
I
K
A
A
T
G
S
A
T
G
K
D
-----
I
S
L
T
L
D
A
S
-
K
--
K
A
E
L
G
--
D
E
G
F
K
L
N
---------
I
G
S
K
G
L
E
V
I
G
A
T
-
D
I
G
V
F
Y
G
T
R
S
-------
V
----
S
Q
M
L
R
Q
G
Q
L
T
L
P
A
G
T
V
A
T
K
P
K
Y
-----
K
E
R
G
---
A
T
L
---
C
A
------
C
Q
I
--
N
I
S
----
T
------
D
W
I
D
R
F
L
S
D
M
A
D
L
R
L
N
Y
-
V
----
L
L
E
M
K
L
----
K
--------
P
E
E
-----------
D
N
----
T
K
K
A
A
T
--
W
S
Y
Y
T
--
R
D
D
V
K
K
F
V
K
K
A
N
N
Y
G
I
D
V
I
P
E
--
I
N
S
P
G
H
M
----------
N
V
-
W
L
E
N
Y
P
---
E
Y
Q
L
A
----------
D
N
S
---------------------
G
R
K
D
P
--
N
K
L
D
ISN-
P
E
A
V
K
F
Y
K
T
L
I
D
E
Y
D
G
----
V
F
T
T
K
Y
W
H
M
G
A
D
E
Y
M
I
G
-----
T
S
--------------
F
D
N
Y
S
K
L
K
T
F
A
E
K
Q
Y
G
-------------
A
G
A
T
P
---
N
D
A
F
T
G
F
I
N
D
I
D
K
Y
V
K
A
--------
K
G
K
Q
L
R
I
W
NDGIVNTKNVSLNKDIVIEYWYGAGRK
P
Q
E
L
V
Q
D
G
Y
T
L
M
N
ATQALYWSRSAQVYKVN
A
A
R
L
Y
N
N
NWNVGTFDGGRQIDKNYDKLT
G
A
K
V
S
I
W
PDSSYFQT
E
N
E
V
E
K
E
I
F
D
G
M
R
F
I
S
Q
M
T
W
SDSRPWAT
W
N
D
M
K
A
D
I
D
K
I
GYP
L
D
I
R
E
YDYTPV
D
A
G
I
Y
D
I
PQLKSISKGP
W
E
L
I
T
T
PDG
Y
Y
Q
M
K
D
TVSG
K
C
L
A
LFTGSKHLDVVTQVG
A
R
P
E
L
R
NCADVSVGQDQRNT
A
N
E
R
N
T
Q
K
W
Q
I
R
A
D
KDG
K
Y
T
I
S
PALTQ
Q
R
L
A
IATGNEQN
I
D
L
E
T
HRPAAG
T
V
A
Q
F
PADLVS
8
PsiBlast_PDB
46.34
26%
-56
- C6 -
3ZXK
1
?
A:
[246-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-----
A
H
Q
G
---
G
I
V
---
D
A
------
P
D
G
T
W
H
Y
V
----
A
F
M
DAYP
G
G
R
I
P
V
V
A
P
L
---------------
R
W
T
A
----
D
--------
G
W
P
-----------
E
V
----
V
T
D
S
Q
G
R
W
G
T
S
Y
P
IP
V
R
G
A
K
N
A
T
E
G
L
A
S
T
D
L
D
E
F
----
R
G
T
R
F
S
E
----------
H
W
-
E
W
N
H
---------------------
N
P
---------------------
D
T
S
K
F
--
T
L
L
G
----
G
N
E
G
G
L
I
L
R
T
A
T
V
T
G
D
----
L
F
A
-
A
R
N
T
L
T
R
R
I
A
G
P
K
A
S
G
I
F
R
L
--------------
D
V
R
G
M
R
D
G
D
R
A
G
A
V
L
F
R
D
R
A
A
Y
----
I
G
V
W
K
Q
G
N
---
E
A
R
I
V
M
V
D
D
L
R
L
N
E
D
G
W
R
T
A
S
T
G
R
V
A
A
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
44.96
12%
-55
- C4 -
3F2E
1
?
A:
[8-90]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
A
V
A
E
Q
V
S
A
V
L
S
--
Q
Y
G
I
T
G
P
N
R
A
I
Y
Q
G
F
G
L
K
V
A
R
--
A
L
N
R
L
G
G
----------
G
P
-
A
L
V
N
M
I
---
N
G
L
K
A
Y
Y
I
S
AFN
A
N
-
P
T
V
---------------------
L
D
A
V
T
--
D
I
I
T
----
G
S
P
T
G
Y
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
44.80
26%
-56
* C6 *
3ZXJ
3
?
A:
[246-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-----
A
H
Q
G
---
G
I
V
---
D
A
------
P
D
G
T
W
H
Y
V
----
A
F
M
DAYP
G
G
R
I
P
V
V
A
P
L
---------------
R
W
T
A
----
D
--------
G
W
P
-----------
E
V
----
V
T
D
S
Q
G
R
W
G
T
S
Y
P
IP
V
R
G
A
K
N
A
T
E
G
L
A
S
T
D
L
D
E
F
----
R
G
T
R
F
S
E
----------
H
W
-
E
W
N
H
---------------------
N
P
---------------------
D
T
S
K
F
--
T
L
L
G
----
G
N
E
G
G
L
I
L
R
T
A
T
V
T
G
D
----
L
F
A
-
A
R
N
T
L
T
R
R
I
A
G
P
K
A
S
G
I
F
R
L
--------------
D
V
R
G
M
R
D
G
D
R
A
G
A
V
L
F
R
D
R
A
A
Y
----
I
G
V
W
K
Q
G
N
---
E
A
R
I
V
M
V
D
D
L
R
L
N
E
D
G
W
R
T
A
S
T
G
R
V
A
A
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------