@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T0845: (2014-07-07 )
MNKLYTTLLIACLAAGFTACNDDDCEDLHLGNLAHYPNVLKGTFPTESQVLELGETLEITPELLNPEGATYSWLVNGKEYSTEPTFSYKIDNPCRADLSCIIKNKYGKVEMSTSFSSNHNFSKGFFYVADGTFNFYDTEKKTAYQDCYASLNAGKTLGIGNYDSANIIHSNGKFYLLVGTSTSNRDHFYIVDAKTLYYENSAVVGANLSGLTILNEQYGLVTGDGIRRIDLKSLNNVRIKNERLLCFYNSIIYNGKVLSNDTYKDESKVKYYDVNELIAAKEGEAPAVTELDIIQKQKINFVLAKDGNVYTLESADNGCNIVKIKNDFTLEKVFANFQPAKGPYHSSPTIGMVASETENIIYLVSTDGAIYKYILGDSDSLKAPFIAAESGVSITAPLQLNQQSGELYVTYTEERKDESKIVVYSKDGKVLHTVDCGESVPSQILFNN
Atome Classification :
(20 SA)
-----------.......-..10....--------....20........30........40-.........50.-.-......60........70........-----80........90---------------........100----........110.......120......--------.--------130..-------.....140.......150---.......160-.-......--170--.---........180.--..-..-...190..-..--.--...-200-------.---..-.-.-..210..-.-.-..-.220.---.------.-------.------....230.-...-.-..-240-..-.------.----------....250-.-......260..--..-...270..--.....280.......290--..-.---.-----.--.------...300-..---.-..-.-.310--....---------------.--------...320-....--.-...-.330-.---..-..-..-..340-.----.---.---......350---...---------.--------....360...-.-.-----------..370.-..---..--...380.--...---..-------------.-.390-----------------..-...----.---..400.......410.......420.-....-.-.-.430-.-.......------440......------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MN
K
L
Y
T
T
-
L
L
I
A
C
L
A
A
--------GFTACNDDDCEDLHLGNLAHYPNVL--KGTFP
T
E
S
Q
V
L
E-L-GETLEI
T
P
E
LLNPEG
A
T
Y
S
W
L
VNGKE-----YSTEP
T
F
S
Y
KID---------------NP
C
R
A
D
L
S
C
-
I
----IKNKYG
K
V
E
M
S
T
SFSSNHNFSK
G
F
F
Y
V
--------A--------DG
T
F
N
-------
F
YDTE
K
K
T
A
Y
Q
D
C
Y
A
SLN---AG
K
T
LGIGNY-D-S
A
N
I
I
H--S----N---G
K
F
Y
L
L
V
GTS-T--SN-R
D
-
H
F
Y
I
-
V
D
A
-
K
T
--
L
--
Y
Y
E-N
S
A
-------
V
---VG-A-N-LS
G
L
T
I
L
-N-E-QY-GL-VT---G------D-------
G
------
I
R
R
I
D
LKS-LN
N
-
V
-
R
I-KN--
E
R
-
L
------
L
----------
C
F
Y
N
S
I
I
-Y-N
G
K
VLSNDTYK--DE-S
K
V
K
Y
Y
D
V
--
N
E
L
I
AAKEGEAPAV
T
E
----
L
D
-
I
---
I
-----
Q
--K------Q
K
I
N
F
V
-
L
A---K-DG-
N
-
V
Y
T
---
L
ESA---------------D--------NG
C
N
---
I
V
K
I--K-NDF-
T
L
---
E
---
K
V
-
F
A-NF-QPA---K----G---P---YHSSPT
I
G
----
M
V
A---------S--------ETE
N
I
I
Y
L
VS-T-D-----------G
A
I
Y
-
K
-
Y
I
---LG--DSDSL-K--A
P
F
---
I
A-------------A-ES-G-----------------
V
S
-
I
T
A
----
P
---
L
Q
LNQQSG
E
L
Y
V
T
YTEERKDES
K
-
I
V
-
V
YSK-D-G-
K
V
L
--
H
-
T
VDCGES------V
P
S
Q
ILFNN------
14
Fugue
81.85
23%
-78
- C7 -
3DSM
-
?
A:
[1-327]
-------------------------
A
S
--------
G
L
F
I
T
N
E
G
N
F
Q
-
Y
S
N
A
T
L
S
Y
Y
D
P
--------------------
A
T
C
E
V
E
N
E
V
F
Y
R
A
N
-----------------------
G
F
K
L
G
---------------
D
----
V
A
Q
S
M
V
----
I
R
D
G
I
G
W
I
V
V
--------
N
N
S
H
V
I
F
A
I
--------
D
--------
I
N
T
F
K
------------------------------
E
V
G
R
I
T
G
F
-
T
-
S
P
R
Y
I
H
F
L
S
----
D
---
E
K
A
Y
V
T
Q
I
W
D
-
Y
--------
R
I
F
I
-
I
N
P
-
K
T
--
Y
--
E
I
T
-
G
Y
I
-------
E
---
C
P
-
D
M
D
M
E
S
G
S
T
E
--
Q
M
V
-
Q
Y
-
G
K
------------------------------------------------------------
Y
----------
V
Y
V
N
C
W
S
-
Y
-
Q
N
R
I
L
K
I
D
T
E
T
--
D
K
------------------------
V
V
D
----
E
L
-
T
---
I
-----
G
--
I
------
Q
P
T
S
L
V
M
D
K
---
Y
-
N
K
M
W
-
T
I
T
DGG
Y
E
G
S
---------------
P
--------
Y
G
Y
E
A
P
S
L
Y
R
I
--
D
A
E
T
F
-
T
V
---
E
---
K
Q
-
F
K
-
F
-----------------
K
---
L
G
D
W
P
S
-
E
----
V
Q
L
---------
N
--------
G
T
R
D
T
L
Y
W
I
N
-
N
-
D
-------------
I
W
-
R
M
P
V
---
E
A
--
D
R
V
P
V
-
R
---
P
F
---
L
E
-------------
F
--
R
-
D
-----------------
T
K
-
Y
Y
G
--------
L
T
V
N
P
N
N
G
E
V
Y
V
A
D
A
I
D
Y
Q
Q
Q
G
I
-
V
Y
-
R
Y
S
P
-
Q
-
G
-
K
L
I
--
D
-
E
F
Y
V
G
I
-------
I
P
G
A
F
C
W
K
L
E
H
H
H
H
H
22
HHSearch
74.90
15%
-75
- C7 -
3DSM
-
?
A:
[1-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
G
L
F
I
T
--------
N
--------
E
G
N
F
Q
YSN
A
T
L
S
Y
Y
D
P
A
T
C
E
V
E
N
E
V
F
Y
R
A
N
---
G
F
-
K
---
L
G
D
-
V
-
A
Q
S
M
V
I
--
R
----
D
---
G
I
G
W
I
V
V
N
N
--------
S
H
-
V
I
F
A
-
I
D
I
-
N
T
--
F
--
K
E
V
-
G
R
I
-------
T
---
G
F
-
T
-
S
-
P
R
Y
I
H
F
L
-
S
-
D
-
E
K
-
A
Y
-
V
T
Q
I
-
W
D-----
Y
-------
R
------
I
F
I
I
N
P
K
T
-
Y
E
I
-
T
-
G
Y
-
I
E
--
C
P
-
D
MDMES
G
S
----------
T
E
Q
M
V
Q
-----------------
Y
G
-
K
Y
V
Y
V
N
C
W
SY
Q
N
R
I
L
K
I
D
T
E
T
D
K
V
V
D
----
E
L
-
T
---
I
-----
G
--
I
------
Q
P
T
S
L
V
-
M
D
---
K
-
Y
N
-
K
-
M
W
T
---
I
T
D
G
---------------
G
YEGSPYGY
E
A
P
S
---
L
Y
R
I
--
D
-
A
E
T
-
F
T
---
V
---
E
K
-
Q
F
-
K
F
-
K
L
G
-------------------
D
W
P
S
E
----
V
Q
L
---------
N
--------
G
T
R
D
T
L
Y
W
I
N
---------------
N
D
I
W
-
R
-
M
P
---
V
E
--
A
D
R
V
P
-
V
--
R
P
F
---
L
E
-------------
F
----
R
-----------------
D
T
-
K
Y
Y
----
G
---
L
T
V
N
P
N
N
G
E
V
Y
V
A
D
A
I
D
Y
Q
Q
Q
G
I
-
V
Y
-
R
Y
S
P
-
Q
-
G
-
K
L
I
--
D
-
E
F
Y
V
G
I
-------
I
P
G
A
F
C
W
K
-------
23
HHSearch
74.67
13%
-58
- C7 -
3TC9
12
?
A:
[10-428]
-----------------------------------------------
G
--
D
F
D
P
N
K
P
V
V
I
--
S
E
F
S
P
K
---
E
G
G
-
L
-
G
T
R
M
L
L
Y
G
E
N
F
G
S
D
I
S
K
I
K
V
T
I
G
G
Q
D
S
K
V
VG
A
K
G
K
S
L
Y
C
V
V
P
A
---------------
K
A
Y
D
G
D
I
K
L
-
S
----
I
L
N
D
E
G
E
E
I
A
N
T
E
A
N
E
K
F
V
Y
Q
K
K
M
L
V
T
--------
T
F
L
G
T
M
Y
DG
N
T
K
Y
D
-------
L
---
K
D
G
-----
P
F
D
D
C
------
G
---
G
F
-
G
-
G
-
A
V
W
L
S
F
--
D
----
P
KNH
N
H
L
Y
L
V
G
E
---------
Q
H
-
P
T
R
L
-
I
D
F
-
E
K
--
E
--
Y
V
S
-
T
V
Y
-------
S
---
G
L
-
S
-
K
-
V
R
T
I
C
W
T
-
H
-
E
-
A
D
S
M
I
-
I
T
---
N
------
D
Q
------
N
NNDRPN
N
Y
I
L
T
R
E
S
-
G
F
K
-
V
I
T
E
-
L
T
--
K
G
-
Q
------
N
----------
C
N
G
A
E
T
H
-
P
I
N
G
E
L
Y
F
N
S
--
W
--
N
A
-
G
Q
V
F
R
Y
D
F
--
T
T
---------
Q
E
T
T
P
----
L
F
-
T
---
I
-----
Q
--
D
SG----
W
E
F
H
I
Q
-
F
H
---
P
-
S
G
-
N
Y
A
Y
I
---
V
V
V
N
---------------
Q
----------
H
Y
---
I
L
R
S
D
Y
D
-
W
K
T
-
K
R
---
L
T
T
P
Y
I
-
V
C
-
G
Q
Q
G
A
K
D
W
V
D
----
G
V
G
K
K
---
A
R
M
H
A
P
R
Q
----
G
T
F
V
K
N
PAYKGS
S
--------
D
-
E
Y
D
F
Y
F
C
D
-
R
E
N
-----------
H
C
I
R
-
I
-
L
T
---
P
---
Q
G
R
V
T
-
T
--
F
A
G
---
R
G
SNG
T
S
G
Y
N
D
G
DLR
Q
-
E
A
-
R
-----------------
F
N
-
H
P
E
----
G
---
I
V
Y
D
E
E
R
E
C
F
F
I
G
D
R
----
E
N
R
R
-
I
R
-
K
I
G
Y
----------------------------------------
15
Fugue
72.68
10%
-22
- C7 -
2J04
-
TFC6_YEAST
B:
[165-674]
SA
R
D
K
I
E
R
I
YG
L
N
K
E
K
L
L
-
L
L
A
K
V
K
E
G
F
E
TSVFDF
P
F
K
N
I
Q
P
D
S
P
Y
F
V
C
L
D
P
P
C
K
K
E
S
A
Y
--
N
K
V
I
G
D
K
N
R
T
V
Y
-
H
-
E
I
N
K
T
E
F
E
N
M
I
K
L
R
T
K
R
L
K
L
L
I
G
E
V
D
-----
A
E
V
S
T
G
D
K
I
E
F
P
VLANGK
R
R
G
F
I
Y
N
V
G
G
T
D
I
A
W
L
N
I
-
E
----
E
N
T
D
I
G
K
D
I
Q
Y
L
A
V
A
V
S
Q
S
S
C
I
Q
I
F
K
M
--------
N
--------
T
S
T
L
H
-------
C
V
K
V
Q
T
I
V
H
S
F
G
E
V
W
D
L
K
WHE
G
C
H
A
P
H
L
V
G
C
-
L
-
S
F
V
S
Q
E
--
G
----
T
---
I
N
F
L
E
I
I
D
N
A
-
T
--
D
V
-
H
V
-
F
K
M
C
-
E
K
P
S
L
T
--
L
--
S
L
A
-
D
S
L
-------
I
---
T
T
-
F
-
D
-
F
L
--------
S
-
P
T
-
T
V
-
V
C
---
G
------
F
-------
K
------
N
G
F
V
A
E
F
D
-
L
T
D
-
P
-
E
V
-
P
S
--
F
Y
-
D
------
Q
----------
V
H
D
S
Y
I
L
-
S
-
V
S
T
A
Y
S
D
F
E
D
T
--
V
V
-
S
T
V
A
V
D
G
Y
--
F
Y
I
F
N
P
K
D
I
A
T
T
K
T
T
V
----
S
R
-
F
---
R
-----
G
--
S
------
N
L
V
P
V
V
-
Y
C
---
P
-
Q
I
-
Y
-
S
Y
I
---
Y
S
D
G
---------------
A
--------
S
S
L
R
---
A
V
P
S
--
R
-
A
A
F
-
A
V
---
H
---
P
L
-
V
S
-
R
E
-
T
T
I
---
T
----
A
---
I
---
G
V
S
R
L
H
P
M
----
V
L
A
---------
G
--------
S
A
D
G
S
L
I
I
T
N
-
A
-
A
-----------
R
R
L
L
-
H
-
G
I
---
Q
K
--
S
L
R
L
W
-
K
--
W
D
Y
---
S
I
-------------
K
-
D
D
-
K
-----------------
Y
R
-
I
D
S
----
S
---
Y
E
V
Y
P
H
G
I
N
I
T
C
T
K
W
N
E
T
S
A
G
G
K
-
C
Y
-
A
F
S
N
-
S
-
A
-
G
L
L
--
T
-
L
E
Y
L
S
L
E
---------------------
17
Fugue
67.48
13%
-49
- C7 -
1RI6
-
6PGL_ECOLI
A:
[2-334]
-------------
S
L
K
Q
T
-
V
Y
I
A
S
P
E
S
--------
Q
----------
Q
I
H
V
W
N
L
N
H
-------
E
G
A
L
T
L
T
Q
V
V
D
V
-
P
-
G
Q
V
Q
P
M
V
V
---
S
P
D
K
R
Y
L
Y
V
G
V
R
P
E
F
---------
R
V
L
A
Y
R
I
A
---------------
P
D
-
D
G
A
L
T
F
-
A
----
A
E
S
A
L
P
G
S
L
T
H
I
S
T
D
H
Q
G
Q
----
F
V
F
V
--------
G
S
YN-----
A
G
N
V
S
-------
V
T
R
L
E
D
G
L
P
V
G
V
V
D
V
V
E
G
---
L
D
G
C
H
S
A
---------
N
I
S
--
P
----
D
---
N
R
T
L
W
V
P
A
L
K
-
Q
--
D
R
-
I
C
-
L
F
T
V
-
S
D
D
-
G
H
--
L
--
V
A
Q
-
D
P
A
-------
E
---
V
T
-
T
-
V
--------------------
E
---
G
------
A
-------
G
------
P
R
H
M
V
F
H
P
-
N
E
Q
-------------------------------
Y
A
Y
C
V
N
E
-
L
-
N
S
S
V
D
V
W
E
L
K
D
--
P
H
-
G
N
I
E
C
V
Q
T
--
L
D
M
M
P
E
N
F
S
D
T
R
W
A
A
D
----
I
H
-
I
---------------------------
T
---
P
-
D
G
R
H
-
L
Y
A
---
C
D
R
T
---------------
A
--------
S
L
I
T
---
V
F
S
V
--
S
-
E
D
G
-
S
V
---
L
---
S
K
-
E
G
-
F
Q
-
P
T
E
---
T
----
Q
---
P
---
R
------
G
----
F
N
V
---------
D
--------
H
S
G
K
Y
L
I
A
A
G
-
Q
-
K
-----------
S
---------------------------------------------------------------------
H
-
H
I
S
----
V
---
Y
E
I
V
G
E
Q
G
L
L
H
E
K
G
R
Y
A
V
G
Q
G
P
M
-
W
V
-
V
V
N
A
-
H
-
E
------------------------------------
18
Fugue
66.97
16%
-19
- C7 -
3B7F
17
?
A:
[16-393]
----------S
A
P
E
S
G
P
V
M
L
L
V
A
T
I
K
G
--------
A
W
F
L
A
S
D
P
A
R
R
T
W
E
L
R
G
P
V
F
L
G
H
T
I
--
H
H
I
V
Q
D
P
R
E
P
E
R
M
L
M
A
-
A
R
T
L
G
P
T
V
F
R
S
D
D
G
G
G
N
W
----
T
E
-----
A
T
R
P
P
A
F
N
-----------------------------------
K
A
P
G
R
V
V
D
H
V
F
W
L
T
P
G
H
A
S
E
P
G
T
W
Y
A
--------
G
--------
T
S
P
Q
G
-------
L
F
R
S
T
D
H
G
A
S
W
E
P
V
A
G
F
N
---
D
-----------------
H
--
P
M---
R
---
R
A
W
T
---
G
G
E
-
P
--
D
G
-
P
K
M
H
S
I
L
-
V
D
P
-
R
D
-------
P
-
K
H
L
-------
Y
---
I
G
M
S
----
S
G
G
V
F
E
-
S
-
T
-
D
A
-
G
T
--------------------------------
D
W
K
P
-
L
N
--------------------------------------------
R
G
C
A
A
N
F
L
P
--
D
P
-
N
V
E
F
G
H
D
P
--
H
C
V
V
Q
H
P
A
A
P
-----------
D
-
I
---
L
-----
Y
--
Q
------
Q
N
H
C
G
I
-
Y
R
M
DR
R
-
E
G
-
V
-
W
K
R
---
I
G
D
A
MPREVG---------
D
--------
I
G
F
P
---
I
V
V
H
--
Q
-
R
D
P
-
R
T
---
V
---
W
V
-
F
P
M
D
-----------------------
G
S
D
V
W
P
----
R
V
S
---------
P
--------
G
G
K
P
A
V
Y
V
T
R
-
D
-
A
-----------
G
E
S
W
-
Q
-
R
Q
D
R
G
L
P
--
T
D
Q
A
W
-
L
--
T
V
K
---
R
Q
-------------
A
M
T
A
-
D
-----------------
A
H
-
A
P
V
----
G
---
V
Y
F
G
T
T
G
G
E
I
W
A
S
-----
A
D
E
G
E
-
H
W
-
Q
C
I
A
-
S
-
H
---
L
--
P
-
H
I
Y
A
V
Q
S
------
A
R
P
------------
27
HHSearch
64.76
11%
-52
- C7 -
4HW6
2
?
A:
[14-432]
---------------------------------------------------
F
N
P
K
E
E
I
V
V
--
E
K
F
L
P
T
E
---
G
R
-
K
-
G
T
R
V
V
V
Y
G
R
N
F
G
N
D
V
S
K
V
K
V
T
I
G
G
Y
P
A
K
V
IN
V
K
G
E
S
L
L
C
I
C
P
S
---------------
K
A
Y
E
G
D
V
K
V
-
S
----
V
V
G
D
D
E
A
E
L
K
S
G
V
C
E
A
K
F
D
Y
Q
Y
N
Y
V
V
T
T
F
L
G
K
L
Y
E
N
--------
N
T
K
W
D
-------
V
---
L
A
G
P
-----
F
D
D
---------
C
G
A
F
-
D
-
N
-
I
W
R
M
M
F
--
D
PNSN
Y
---
D
D
L
Y
W
V
G
Q
R
---------
D
-
A
F
R
H
-
V
D
F
-
V
N
--
Q
--
Y
V
D
-
I
K
T
-------
T
---
N
I
-
G
-
Q
-
C
A
D
V
N
F
T
-
L
-
N
-
G
D
-
M
V
-
V
V
---
D
------
D
QSSDTNT
G
------
I
Y
L
F
T
R
A
S
-
G
F
T
-
E
-
R
L
S
L
C
--
N
A
-
R
------
G
----------
A
K
T
C
A
V
H
-
P
Q
N
G
K
I
Y
Y
T
R
--
Y
--
H
H
-
A
M
I
S
S
Y
D
P
--
A
T
G
T
L
T
--------
E
E
----
E
V
-
M
---
M
-----
D
TK
G
------
S
N
F
H
I
V
-
W
H
---
P
-
T
G
D
W
-
A
Y
I
---
I
Y
N
G
-------------------------
K
H
C
---
I
Y
R
V
D
Y
N
-
R
E
T
-
G
K
---
L
AVP
Y
I
-
V
C
-
G
Q
-
H
S
S
---
P
GW
V
D
G
---
M
G
TG
A
R
L
W
G
P
N
Q
----
G
I
F
---------
V
K
N
EAYAGE
E
D
E
Y
D
F
Y
F
C
D
-
R
D
S
-----------
H
T
V
R
-
V
-
L
T
---
P
E
---
G
R
V
T
-
T
--
Y
A
G
---
R
G
NSRE
W
G
Y
V
D
G
ELR
S
-
Q
A
-
L
-----------------
F
N
-
H
P
T
----
S
---
I
A
Y
D
M
K
R
K
C
F
Y
I
G
D
C
----
D
N
H
R
-
V
R
-
K
I
A
P
-
E
--------------------------------------
30
HHSearch
60.77
13%
-62
- C7 -
3DSM
-
?
A:
[2-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
L
F
I
T
N
E
G
N
F
Q
--
Y
S
-
N
A
-
T
L
S
Y
-
Y
D
P
-
A
T
--
C
--
E
V
E
-
N
E
V
F
Y
R
A
N
GF
K
---
L
G
-
D
-
V
-
A
Q
S
M
V
I
--
R
-
D
-
G
I
-
G
W
-
I
V
---
V
NN----
S
-------
H
V
-----
I
F
A
I
D
I
N
T
-
F
K
E
-
V
-
G
R
-
I
T
--
G
F
-
T
------
S
----------
P
R
Y
I
H
F
L
-
S
-
D
E
K
A
Y
V
T
Q
--
I
--
W
D
-
Y
R
I
F
I
I
N
P
--
K
---------
T
Y
E
I
T
G
----
Y
I
-
E
---
C
-----
P
--
D
MDMES
G
S
T
E
Q
M
V
-
Q
----
Y
-
G
K
-
Y
-
V
Y
V
---
N
C
W
S
------------------------
Y
Q
N
R
---
I
L
K
I
--
D
-
T
E
T
-
D
K
---
V
---
V
D
-
E
L
-
T
I
-
G
I
--------------------
Q
-
P
T
S
----
L
V
M
---------
D
---------
K
Y
N
K
M
W
T
I
T
-
D
-
G
GYEGSPYGY
E
A
P
S
L
Y
-
R
-
I
D
---
A
E
--
T
F
T
V
E
-
K
--
Q
F
K
------------------
F
-
K
L
-------------------
G
D
-
W
P
S
----
E
---
V
Q
L
N
G
T
R
D
T
L
Y
W
I
N
-------
N
D
-
I
W
-
R
M
P
V
-
E
-
A
D
R
V
P
VR
P
-
F
L
E
F
R
D
T
------
K
Y
Y
G
L
T
V
N
-------
21
Fugue
60.76
12%
-14
- C4 -
1EYB
-
HGD_HUMAN
A:
[2-440]
-----------
A
E
L
K
Y
I
S
-------------------------
G
F
G
N
E
C
S
S
E
D
P
R
C
P
G
S
L
PE
G
Q
N
N
P
Q
V
C
P
Y
N
L
-
Y
-
A
E
Q
L
S
G
S
A
F
T
C
P
R
S
T
N
K
R
S
W
L
Y
R
I
L
P
-----
S
V
S
H
K
P
F
E
S
I
D
E
---------------
G
H
V
T
H
N
W
D
E
-
V
DPDP
N
Q
L
R
W
K
P
F
E
I
P
K
A
S
Q
K
K
V
D
F
V
S
G
L
H
T
L
--------
C
----------------------------------------------
G
A
G
D
--------
I
K
--
S
----
N
---
N
G
L
A
I
H
I
F
L
C
-
N
--
T
S
M
E
N
-
R
C
F
Y
N
S
D
G
-
D
F
--
L
--
I
V
P
-
Q
K
---------------------
G
N
L
L
I
-
Y
-
T
-
E
F
-
G
K
M
L
V
---
Q
------
P
-------
N
------
E
I
C
V
I
Q
R
G
M
R
F
S
-
I
-
D
V
-
F
E
--
E
T
-
R
------
G
----------
Y
I
L
E
V
Y
-----
G
V
H
F
E
L
P
D
L
G
--
P
I
-
G
A
N
G
L
A
N
--------
P
R
D
F
L
I
P
I
A
W
Y
----
E
D
-
R
---
Q
-----
V
--
P
------
G
G
Y
T
V
I
-
N
K
---
Y
-
Q
G
-
K
-
L
F
A
---
A
K
Q
D
---------------
V
--------
S
P
F
N
---
V
V
A
W
--
H
-
G
N
Y
-
T
P
---
Y
---
K
Y
N
L
K
-
N
F
M
V
I
N
---
S
V---
A
---
F
---
D
H
A
D
P
S
I
F
----
T
V
L
---------
T
--------
A
K
S
V
R
P
G
V
A
I
-
A
-
D
-----------
F
V
I
F
P
P
-
R
W
---
G
V
--
A
D
K
T
F
-
R
--
P
P
Y
---
Y
H
-------------
R
-
N
C
M
S
E
F
M
G
L
IRGFLPG
G
G
S
L
H
S
T
M
T
P
H
----
G
---
P
D
A
D
C
F
E
K
A
S
K
V
K
L
A
P
E
R
I
A
D
G
T
M
A
F
M
F
E
S
S
-
L
---
S
L
A
--
V
-
T
K
W
G
L
K
A
------
S
R
L
K
S
H
F
T
P
NSRN--
36
HHSearch
58.81
13%
-64
- C7 -
2QC5
-
?
A:
[22-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
G
I
T
S
--
S
E---
D
---
G
K
V
W
F
T
Q
H
K
--------
A
N
-
K
I
S
S
-
L
D
Q
-
S
G
-----
R
-
I
-
K
E
F
-------
E
V
PT
P
D
-
A
-
K
-
V
M
C
L
I
V
S
-
S
-
L
-
G
D
-
I
W
-
F
T
---
E
NGA---
N
-------
K
------
I
G
K
L
S
-
K
K
-
G
G
F
-
T
-
E
Y
-
P
L
PQ
P
D
-
S
------
G
----------
P
Y
G
I
T
E
G
-
L
-
N
G
D
I
W
F
T
Q
--
L
--
N
G
-
D
R
I
G
K
L
T
A
--
D
G
----------
T
I
Y
E
----
Y
D
-
L
PN-
K
-----
G
--
S
------
Y
P
A
F
I
T
-
L
G
---
S
-
D
N
-
A
-
L
W
F
---
T
E
N
Q
-------------------------
N
N
S
---
I
G
R
I
--
T
-
N
T
G
-
K
L
---
E
---
E
Y
-
P
L
-
P
T
-
N
--------------------
A
A
A
P
V
G
----
I
T
S
---------
G
--------
N
D
-
G
A
L
W
F
V
E
-
I
M
G
-----------
N
K
I
G
-
R
-
I
T
---
T
---
T
G
E
I
S
-
E
--
Y
------
D
-------------
I
-
P
T
-
P
-----------------
N
A
-
R
P
H
----
A
---
I
T
A
G
K
N
-
S
E
I
W
F
T
E
W
----
G
A
N
Q
-
I
G
-
R
I
T
N
-
D
-
N
-
T
I
Q
--
E
Y
Q
L
Q
T
E
N
A
------
E
P
H
G
I
T
F
--------
41
HHSearch
58.62
11%
-54
- C7 -
3U4Y
2
?
A:
[22-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
-------
F
F
S
T
D
T
L
E
I
L
N
Q
I
T
L
G
Y
---------------
D
-
F
V
D
T
A
I
--
T
S---
D
C--
S
N
V
V
V
T
S
D
-------
F
-
C
Q
-
T
L
V
Q
-
I
E
T
-
Q
L
E
P
P
--
K
V
V
-
A
I
--------
Q
---
E
G
-
Q
-
S
S
M
A
D
V
D
I
T
-
P
-
D
-
D
Q
-
F
A
-
V
T
---
V
T
G
LNHP
F
-------
N
------
M
Q
S
Y
S
F
L
K
-
N
K
F
-
I
-
S
T
-
I
P
--
I
P
-
Y
------
D
----------
A
V
G
I
A
I
S
-
P
-
N
G
N
G
L
I
L
I
D
-
R
--
S
S
A
N
T
V
R
R
F
K
I
--
D
--------
A
D
G
V
L
F
D
TG
Q
E
F
I
-
S
---
G
-----
G
--
T
------
R
P
F
N
I
T
-
F
T
---
P
-
D
G
-
N
F
A
F
V
---
A
N
L
I
---------------
G
----------
N
S
---
I
G
I
L
--
E
-
T
Q
N
P
E
N
I
T
L
L
---
N
A
-
V
-----
G
T
-------------------
N
N
L
P
G
T
----
I
V
V
---------
S
--------
R
D
G
S
T
V
Y
V
L
T
---
E
-----------
S
T
V
D
-
V
-
F
N
---
F
N
--
Q
L
S
G
T
-
L
--
S
F
V
---
K
S
FGHG---------
L
-
L
I
-------------------
D
P
-
R
P
L
FGAN
Q
---
M
A
L
N
K
T
E
T
K
L
F
I
S
A
N
----
I
S
R
E
-
L
K
-
V
F
T
I
-
S
-
G
-
K
V
V
--
G
-
Y
V
A
G
I
E
-------
A
N
G
G
I
A
I
C
-------
25
HHSearch
55.39
16%
-62
- C7 -
3V64
-
LRP4_RAT
C:
[55-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
Q
-
V
L
P
-
H
R
--
S
--
E
Y
T
-
L
L
L
-------
N
---
N
L
-
E
-
N
-
A
I
A
L
D
F
H
H
R
-
R
-
E
L
-
V
F
-
W
S
---
D
------
V
TLD----
R
------
I
L
R
A
N
L
N
G
-
S
N
V
-
E
-
E
V
-
V
S
--
T
G
L
E
------
S
----------
P
G
G
L
A
V
D
W
V
-
H
D
K
L
Y
W
T
D
--
S
--
G
T
-
S
R
I
E
V
A
N
L
--
D
G
A
---------
H
R
K
V
----
L
L
-
W
Q--
S
-----
L
--
E
------
K
P
R
A
I
A
-
L
H
---
P
M
E
G
-
T
-
I
Y
W
---
T
D
W
G
---------------
N
---------
T
P
R
---
I
E
A
S
--
S
-
M
D
G
-
S
G
---
R
---
R
I
-
I
A
-
D
T
---------------------
H
L
F
W
P
N
G
----
L
T
I
---------
D
--------
Y
A
G
R
R
M
Y
W
V
D
-
A
K
H
-----------
H
V
I
E
-
R
-
A
N
---
L
D
--
G
S
H
R
K
-
A
----
V
---
I
----------------
S
Q
-
G
-----------------
L
P
-
H
P
F
----
A
---
I
T
V
F
--
E
D
S
L
Y
W
T
D
W
----
H
T
K
S
-
I
N
-
S
A
N
K
F
T
-
G
-
K
N
Q
--
E
-
I
I
R
N
K
L
H
------
F
P
M
D
I
H
T
--------
31
HHSearch
55.19
15%
-60
- C7 -
3V65
-
LRP4_RAT
B:
[97-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
R
Q
-
V
L
P
-
H
R
--
S
--
E
Y
T
-
L
L
L
-------
N
---
N
L
-
E
-
N
-
A
I
A
L
D
F
H
-
H
R
R
-
E
L
-
V
F
-
W
S
---
D
------
V
TLD----
R
------
I
L
R
A
N
L
N
G
-
S
N
V
-
E
-
E
V
-
V
S
--
T
G
L
E
------
S
----------
P
G
G
L
A
V
D
W
V
-
H
D
K
L
Y
W
T
D
--
S
--
G
T
-
S
R
I
E
V
A
N
L
--
D
G
A
---------
H
R
K
V
----
L
L
-
W
Q--
S
-----
L
--
E
------
K
P
R
A
I
A
-
L
H
---
P
M
E
G
-
T
-
I
Y
W
---
T
D
W
G
---------------
N
---------
T
P
R
---
I
E
A
S
--
S
-
M
D
G
-
S
G
---
R
---
R
I
-
I
A
-
D
T
-
H
--------------------
L
F
W
P
N
G
----
L
T
I
---------
D
--------
Y
A
G
R
R
M
Y
W
V
D
-
A
-
K
H----------
H
V
I
E
-
R
-
A
N
---
L
D
--
G
S
H
R
K
-
A
----
V
---
I
----------------
S
Q
-
G
-----------------
L
P
-
H
P
F
----
A
---
I
T
V
F
E
D
--
S
L
Y
W
T
D
W
----
H
T
K
S
-
I
N
-
S
A
N
K
F
T
-
G
-
K
N
Q
--
E
-
I
I
R
N
K
L
H
------
F
P
M
D
I
H
T
L
-------
34
HHSearch
55.15
14%
-61
- C7 -
1RWI
-
B:
[26-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
G
V
A
V
--
D
S---
A
---
G
N
V
Y
V
T
S
E
G
------
M
-
Y
G
-
R
V
V
K
-
L
A
T
----------
T
V
L
P
F
-------
N
---
G
L
-
Y
-
Q
-
P
Q
G
L
A
V
D
-
G
-
A
-
G
T
-
V
Y
-
V
T
---
D
FN----
N
-------
R
------
V
V
T
L
A
A
G
S
-
N
N
Q
-
T
-
V
L
-
P
F
D-
G
L
-
N
------
Y
----------
P
E
G
L
A
V
D
-
T
-
Q
G
A
V
Y
V
A
D
--
R
--
G
N
-
N
R
V
V
K
L
A
A
--
G
S
K
T
Q
T
V
L
------------
P
F
-
T
---
G
-----
L
--
N
------
D
P
D
G
V
A
-
V
D
---
N
-
S
G
-
N
-
V
Y
V
---
T
D
T
D
-------------------------
N
N
R
---
V
V
K
L
--
E
-
A
E
S
-
N
N
---
Q
---
V
V
-
L
P
--
F
-
T
-------------------
D
I
T
A
P
W
G
----
I
A
V
---------
D
--------
E
A
-
G
T
V
Y
V
T
E
-
H
N
T
-----------
N
Q
V
V
-
K
-
L
L
---
A
G
--
S
T
T
S
T
-
V
--
L
P
F
---------------------
T
-
G
-----------------
L
N
-
T
P
L
----
A
---
V
A
V
D
S
-
D
R
T
V
Y
V
A
D
R
----
G
N
D
R
-
V
V
-
K
L
T
S
-
L
-
E
------------------------------------
32
HHSearch
54.61
13%
-60
- C7 -
2DG1
1
DRP35_STAAM
A:
[46-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
L
E
G
L
N
F
D
-
R
-
Q
-
G
Q
-
L
F
-
L
L
D
VF
E
------
G
-------
N
------
I
F
K
I
N
P
E
T
-
K
E
I
-
K
-
R
P
-
F
V
S-
H
K
-
A
------
N
----------
P
A
A
I
K
I
H
-
K
-
D
G
R
L
F
V
C
Y
L
G
D
FK
S
T
-
G
G
I
F
A
A
T
E
--
N
G
D
N
---------
L
Q
D
----
I
I
-
E
DLS
T
-----
A
--
Y
------
C
I
D
D
M
V
-
F
D
---
S
-
K
G
-
G
-
F
Y
F
---
T
D
F
R
---------------
G
YSTN----
P
L
G
G
---
V
Y
Y
V
--
S
-
P
D
F
-
R
T
---
V
---
T
P
-
I
I
-
Q
N
----------------------
I
S
V
A
N
G
----
I
A
L
---------
S
--------
T
D
E
K
V
L
W
V
T
E
-
T
T
A
-----------
N
R
L
H
-
R
-
I
A
---
L
E
D-
D
G
V
T
I
-
Q
--
P
F
G
ATI
P
Y
-------------
Y
-
F
T
-
G
-----------------
H
E
-
G
P
D
----
S
---
C
C
I
D
S
-
D
D
N
L
Y
V
A
M
Y
----
G
Q
G
R
-
V
L
-
V
F
N
K
-
R
-
G
-
Y
P
I
--
G
-
Q
I
L
I
P
G
R
DEGHML
R
S
T
H
P
Q
F
I
-------
42
HHSearch
54.45
15%
-37
- C7 -
3VGZ
-
YNCE_ECOLI
A:
[52-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
N
A
L
W
L
A
T
S
Q
S
-
R
KL
D
K
-
G
G
-
V
V
Y
R
-
L
D
P
-
V
T
--
L
--
E
V
T
-
Q
A
I
-------
H
---
N
D
-
L
-
K
-
P
F
G
A
T
I
N
-
N
-
T
T
Q
T
-
L
W
-
F
G
---
N
TVN---
S
-------
A
------
V
T
A
I
D
A
K
T
-
G
E
V
-
K
-
G
R
-
L
V
--
L
D
-
D
------
R
KRTEEVR
P
L
Q
P
R
E
L
V
A
D
-
D
-
A
T
N
T
V
Y
I
S
G
I
G
--
K
E
-
S
V
I
W
V
V
D
G
--
G
N
---------
I
K
L
K
T
----
A
I
-
Q
N--
T
-----
G
--
K
------
M
S
T
G
L
A
-
L
D
---
S
-
E
G
-
K
-
R
L
Y
---
T
T
N
A
-------------------------
D
G
E
---
L
I
T
I
--
D
-
T
A
D
-
N
K
---
I
---
L
S
-
R
K
-
K
L
-
L
D
D
---
G
----
K
---------
E
H
F
F
I
N
----
I
S
L
---------
D
--------
T
A
R
Q
R
A
F
I
T
D
S
K
-
A
-----------
A
E
V
L
-
V
-
V
D
---
T
R
--
N
G
N
I
L
-
A
--
K
V
A
------------------
A
-
P
E
-
S
----------------------
L
----
A
---
V
L
F
N
P
A
R
N
E
A
Y
V
T
H
R
----
Q
A
G
K
-
V
S
-
V
I
D
A
K
S
-
Y
-
K
V
V
--
K
-
T
F
D
T
P
T
-------
H
P
N
S
L
A
L
--------
35
HHSearch
53.92
14%
-63
* C7 *
3SOV
6
LRP6_HUMAN
A:
[13-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
D
L
R
L
-
V
D
A
-
T
N
--
G
K
E
N
A
T
-
I
V
V
-------
G
---
G
L
-
E
-
D
-
A
A
A
V
D
F
V
-
F
S
H
-
G
L
-
I
Y
-
W
S
---
D
------
V
SEE----
A
------
I
K
R
T
E
F
N
K
-
T
E
S
V
Q
-
N
V
-
V
V
S-
G
L
-
L
------
S
----------
P
D
G
L
A
C
D
-
W
L
G
E
K
L
Y
W
T
D
--
S
--
E
T
-
N
R
I
E
V
S
N
L
--
D
G
S
---------
L
R
K
V
----
L
F
W
Q
---
E
-----
L
--
D
------
Q
P
R
A
I
A
-
L
D
---
P
S
S
G
-
F
-
M
Y
W
---
T
D
W
G
------------------------
E
V
P
K
---
I
E
R
A
--
G
-
M
D
G
-
S
S
---
R
---
F
I
-
I
I
-
N
S
-
E
--------------------
I
Y
W
P
N
G
----
L
T
L
---------
D
--------
Y
E
E
Q
K
L
Y
W
A
D
-
A
K
L
-----------
N
F
I
H
-
K
-
S
N
---
L
D
--
G
T
N
R
Q
-
A
----
V
---
V
----------------
K
G
-
S
-----------------
L
P
-
H
P
F
----
A
---
L
T
L
F
--
E
D
I
L
Y
W
T
D
W
----
S
T
H
S
-
I
L
-
A
C
N
K
-
Y
T
G
-
E
G
L
--
R
-
E
I
H
S
D
I
F
------
S
P
M
D
I
H
A
--------
13
Fugue
53.07
12%
-31
- C7 -
3HXJ
-
?
A:
[12-322]
--------------------------------------------------------------
K
W
E
F
L
I
G
N
S
I
D
----------
S
S
P
I
L
A
K
N
G
T
I
Y
L
G
S
S
N
K
N
L
-----
Y
A
I
N
T
D
G
S
V
K
W
F
---------------
F
K
---------------------
S
G
E
I
I
E
C
R
P
S
I
G
K
D
G
T
I
Y
F
--------
G
--------
S
D
K
V
Y
-------
A
I
N
P
D
G
T
E
K
W
R
F
D
T
S
D
F
T
---
I
F
E
D
I
L
Y
V
T
S
M
D
G
H
L
Y
A
I
N
--
T
----
D
---
G
T
E
K
W
R
F
K
T
K
-
K
--
A
I
-
Y
A
-
T
P
I
V
-
S
E
D
-
G
T
--
I
--
Y
V
G
-
S
N
---------------------------
D
-
N
-
Y
L
-
Y
A
-
I
N
---
P
------
D
-------
G
------
T
E
K
W
R
F
K
T
-
N
D
A
-
I
-
T
------------------------------------------------------------------------
S
A
A
S
I
G
K
----
D
G
-
T
------------------------
I
-
Y
F
---
G
-
S
D
-
K
-
V
Y
A
---
I
N
P
-------------------------
D
G
T
E
---
K
W
N
F
--
Y
-------------------------
A
---
G
----
Y
---
W
---
T
V
T
R
P
A
I
S
EDG
T
I
Y
V
---------
T
--------
S
L
D
G
H
L
Y
A
I
N
-
P
-
D
-----------
G
T
E
K
-
W
-
R
F
---
K
T
--
G
K
R
I
E
-
S
--
S
P
V
---
I
G
-------------
N
-
T
D
-
T
-----------------
I
Y
-
F
G
S
----
Y
DG
H
L
Y
A
I
N
P
D
G
T
E
K
W
N
F
E
T
G
S
W
I
I
A
T
-
P
V
-
I
D
E
N
-
G
----------
T
I
Y
F
G
T
R
------
N
G
K
F
Y
A
L
F
N
------
40
HHSearch
51.98
13%
-57
- C7 -
3E5Z
-
?
A:
[29-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-
T
E
G
P
V
Y
V
-
P
-
A
-
R
S
A
V
I
-
F
S
DVR
Q
------
N
-------
R
------
T
W
A
W
S
D
D
G
-
Q
L
S
-
P
--
E
-
M
H
--
P
S
-
H
------
H
----------
Q
N
G
H
C
L
N
-
K
-
Q
G
H
L
I
A
C
S
--
H
--
G
L
-
R
R
L
E
R
Q
R
E
--
P
G
G
E
W
E
S
I
A
D
S
F
--
E
------
G
-
K
---
K
-----
L
--
N
------
S
P
N
D
V
C
-
L
A
---
P
-
D
G
-
S
-
L
W
F
---
S
D
P
T
Y
G
I
D
K
P
EEGY
G
G
E
M
E
L
--------
P
G
R
W
---
V
F
R
L
--
A
-
P
D
G
-
T
L
---
S
---
A
P
-
I
R
-
D
-----------------------
R
V
K
P
N
G
----
L
A
F
---------
L
--------
P
S
G
N
L
L
V
S
D
T
-
G
-
D
-----------
N
A
T
H
-
R
-
Y
C
---
L
N
--
A
R
G
E
T
E
Y
QG
V
H
F
---
T
V
------------------
E
-----------------
P
G
-
K
T
D
----
G
---
L
R
V
D
A
-
G
G
L
I
W
A
S
A
------
G
D
G
-
V
H
-
V
L
T
P
-
D
-
G
-
D
E
L
--
G
-
R
V
L
T
P
Q
T
-------
T
S
N
L
C
F
--------
26
HHSearch
50.92
13%
-68
- C7 -
3G4E
-
RGN_HUMAN
A:
[14-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
-
G
E
S
P
V
W
E
-
E
V
S
-
N
S
-
L
L
-
F
V
DIP
A
------
K
-------
K
------
V
C
R
W
D
S
F
T
-
K
Q
V
-
Q
-
R
V
-
T
M
---
D
-
A
------
P
----------
V
S
S
V
A
L
R
-
Q
-
S
G
G
Y
V
A
T
------
I
G
-
T
K
F
C
A
L
N
W
--
K
E
Q
S
---------
A
V
V
----
L
A
-
T
---
V
DNDKK
N
--
N
------
R
F
N
D
G
K
-
V
D
---
P
-
A
G
-
R
-
Y
F
A
---
G
T
M
A
EETAPAVLE------
R
--------
H
Q
G
A
---
L
Y
S
L
--
F
-
P
D
H
-
H
V
---
K
---
K
Y
-
F
D
-
Q
V
-----------------------
D
I
S
N
G
----
L
D
W
---------
S
--------
L
D
H
K
I
F
Y
Y
I
D
-
S
L
S
-----------
Y
S
V
D
-
A
-
F
D
---
Y
D
LQ
T
G
Q
I
S
-
N
R-
R
S
V
---
Y
K
-------------
L
-
E
K
-
E
-----------------
E
Q
-
I
P
D
----
G
---
M
C
I
D
A
-
E
G
K
L
W
V
A
C
Y
----
N
G
G
R
-
V
I
-
R
L
D
P
-
V
T
G
-
K
R
L
--
Q
-
T
V
K
L
P
V
D
------
K
T
T
S
C
C
F
G
-------
User Run . : Multi Template Modeling Result:
(5 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
K
L
Y
T
T
L
L
I
A
C
L
A
A
GFTACNDDDCEDLHLGNLAHYPNVLKGTFP
T
E
S
Q
V
L
ELGETLEI
T
P
E
LLNPEG
A
T
Y
S
W
L
VNGKEYSTEP
T
F
S
Y
KIDNP
C
R
A
D
L
S
C
I
IKNKYG
K
V
E
M
S
T
SFSSNHNFSK
G
F
F
Y
V
ADG
T
F
N
F
YDTE
K
K
T
A
Y
Q
D
C
Y
A
SLNAG
K
T
LGIGNYDS
A
N
I
I
HSNG
K
F
Y
L
L
V
GTSTSNR
D
H
F
Y
I
V
D
A
K
T
L
Y
Y
EN
S
A
V
VGANLS
G
L
T
I
L
NEQYGLVTGD
G
I
R
R
I
D
LKSLN
N
V
R
IKN
E
R
L
L
C
F
Y
N
S
I
I
YN
G
K
VLSNDTYKDES
K
V
K
Y
Y
D
V
N
E
L
I
AAKEGEAPAV
T
E
L
D
I
I
Q
KQ
K
I
N
F
V
L
AKDG
N
V
Y
T
L
ESADNG
C
N
I
V
K
IKNDF
T
L
E
K
V
F
ANFQPAKGPYHSSPT
I
G
M
V
ASETE
N
I
I
Y
L
VSTDG
A
I
Y
K
Y
I
LGDSDSLKA
P
F
I
AAESG
V
S
I
T
A
P
L
Q
LNQQSG
E
L
Y
V
T
YTEERKDES
K
I
V
V
YSKDG
K
V
L
H
T
VDCGESV
P
S
Q
ILFNN
66
96.17
100%
-69
- C- -
M066
-
A:
[28-562]
---------------------------
L
H
L
G
N
L
A
H
Y
P
N
V
L
K
G
T
F
P
T
E
S
Q
V
L
E
L
G
E
T
L
E
I
T
P
E
L
L
N
P
E
G
A
T
Y
S
W
L
V
N
G
K
E
Y
S
T
E
P
T
F
S
Y
K
I
D
N
P
C
R
A
D
L
S
C
I
I
K
N
K
Y
G
K
V
E
M
S
T
S
F
S
S
N
H
N
F
S
K
G
F
F
Y
V
A
D
G
T
F
N
F
Y
D
T
E
K
K
T
A
Y
Q
D
C
Y
A
S
L
N
A
G
K
T
L
G
I
G
N
Y
D
S
A
N
I
I
H
S
N
G
K
F
Y
L
L
V
G
T
S
T
S
N
R
D
H
F
Y
I
V
D
A
K
T
L
Y
Y
E
N
S
A
V
V
G
A
N
L
S
G
L
T
I
L
N
E
Q
Y
G
L
V
T
G
D
G
I
R
R
I
D
L
K
S
L
N
N
V
R
I
K
N
E
R
L
L
C
F
Y
N
S
I
I
Y
N
G
K
V
L
S
N
D
T
Y
K
D
E
S
K
V
K
Y
Y
D
V
N
E
L
I
A
A
K
E
G
E
A
P
A
V
T
E
L
D
I
I
Q
K
Q
K
I
N
F
V
L
A
K
D
G
N
V
Y
T
L
E
S
A
D
N
G
C
N
I
V
K
I
K
N
D
F
T
L
E
K
V
F
A
N
F
Q
P
A
K
G
P
Y
H
S
S
P
T
I
G
M
V
A
S
E
T
E
N
I
I
Y
L
V
S
T
D
G
A
I
Y
K
Y
I
L
G
D
S
D
S
L
K
A
P
F
I
A
A
E
S
G
V
S
I
T
A
P
L
Q
L
N
Q
Q
S
G
E
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
I
V
V
Y
S
K
D
G
K
V
L
H
T
V
D
C
G
E
S
V
P
S
Q
I
L
F
N
N
61
95.03
100%
-64
- C- -
M061
-
A:
[28-531]
---------------------------
L
H
L
G
N
L
A
H
Y
P
N
V
L
K
G
T
F
P
T
E
S
Q
V
L
E
L
G
E
T
L
E
I
T
P
E
L
L
N
P
E
G
A
T
Y
S
W
L
V
N
G
K
E
Y
S
T
E
P
T
F
S
Y
K
I
D
N
P
C
R
A
D
L
S
C
I
I
K
N
K
Y
G
K
V
E
M
S
T
S
F
S
S
N
H
N
F
S
K
G
F
F
Y
V
A
D
G
T
F
N
F
Y
D
T
E
K
K
T
A
Y
Q
D
C
Y
A
S
L
N
A
G
K
T
L
G
I
G
N
Y
D
S
A
N
I
I
H
S
N
G
K
F
Y
L
L
V
G
T
S
T
S
N
R
D
H
F
Y
I
V
D
A
K
T
L
Y
Y
E
N
S
A
V
V
G
A
N
L
S
G
L
T
I
L
N
E
Q
Y
G
L
V
T
G
D
G
I
R
R
I
D
L
K
S
L
N
N
V
R
I
K
N
E
R
L
L
C
F
Y
N
S
I
I
Y
N
G
K
V
L
S
N
D
T
Y
K
D
E
S
K
V
K
Y
Y
D
V
N
E
---------
P
A
V
T
E
L
D
I
I
Q
K
Q
K
I
N
F
V
L
A
K
D
G
N
V
Y
T
L
E
S
A
D
N
G
C
N
I
V
K
I
K
N
D
F
T
L
E
K
V
F
A
N
F
Q
P
A
K
G
P
Y
H
S
S
P
T
I
G
M
V
A
S
E
T
E
N
I
I
Y
L
V
S
T
D
G
A
I
Y
K
Y
I
L
G
D
S
D
S
L
K
A
P
F
I
A
A
E
S
G
V
S
I
T
A
P
L
Q
L
N
Q
Q
S
G
E
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
I
V
V
Y
S
K
D
G
K
V
L
H
T
V
D
C
G
E
S
V
P
S
Q
I
L
F
N
N
63
93.05
100%
-68
- C- -
M063
-
A:
[28-562]
---------------------------
L
H
L
G
N
L
A
H
Y
P
N
V
L
K
G
T
F
P
T
E
S
Q
V
L
E
L
G
E
T
L
E
I
T
P
E
L
L
N
P
E
G
A
T
Y
S
W
L
V
N
G
K
E
Y
S
T
E
P
T
F
S
Y
K
I
D
N
P
C
R
A
D
L
S
C
I
I
K
N
K
Y
G
K
V
E
M
S
T
S
F
S
S
N
H
N
F
S
K
G
F
F
Y
V
A
D
G
T
F
N
F
Y
D
T
E
K
K
T
A
Y
Q
D
C
Y
A
S
L
N
A
G
K
T
L
G
I
G
N
Y
D
S
A
N
I
I
H
S
N
G
K
F
Y
L
L
V
G
T
S
T
S
N
R
D
H
F
Y
I
V
D
A
K
T
L
Y
Y
E
N
S
A
V
V
G
A
N
L
S
G
L
T
I
L
N
E
Q
Y
G
L
V
T
G
D
G
I
R
R
I
D
L
K
S
L
N
N
V
R
I
K
N
E
R
L
L
C
F
Y
N
S
I
I
Y
N
G
K
V
L
S
N
D
T
Y
K
D
E
S
K
V
K
Y
Y
D
V
N
E
L
I
A
A
K
E
G
E
A
P
A
V
T
E
L
D
I
I
Q
K
Q
K
I
N
F
V
L
A
K
D
G
N
V
Y
T
L
E
S
A
D
N
G
C
N
I
V
K
I
K
N
D
F
T
L
E
K
V
F
A
N
F
Q
P
A
K
G
P
Y
H
S
S
P
T
I
G
M
V
A
S
E
T
E
N
I
I
Y
L
V
S
T
D
G
A
I
Y
K
Y
I
L
G
D
S
D
S
L
K
A
P
F
I
A
A
E
S
G
V
S
I
T
A
P
L
Q
L
N
Q
Q
S
G
E
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
I
V
V
Y
S
K
D
G
K
V
L
H
T
V
D
C
G
E
S
V
P
S
Q
I
L
F
N
N
62
92.99
100%
-64
- C- -
M062
-
A:
[28-552]
---------------------------
L
H
L
G
N
L
A
H
Y
P
N
V
L
K
G
T
F
P
T
E
S
Q
V
L
E
L
G
E
T
L
E
I
T
P
E
L
L
N
P
E
G
A
T
Y
S
W
L
V
N
G
K
E
Y
S
T
E
P
T
F
S
Y
K
I
D
N
P
C
R
A
D
L
S
C
I
I
K
N
K
Y
G
K
V
E
M
S
T
S
F
S
S
N
H
N
F
S
K
G
F
F
Y
V
A
D
G
T
F
N
F
Y
D
T
E
K
K
T
A
Y
Q
D
C
Y
A
S
L
N
A
G
K
T
L
G
I
G
N
Y
D
S
A
N
I
I
H
S
N
G
K
F
Y
L
L
V
G
T
S
T
S
N
R
D
H
F
Y
I
V
D
A
K
T
L
Y
Y
E
N
S
A
V
V
G
A
N
L
S
G
L
T
I
L
N
E
Q
Y
G
L
V
T
G
D
G
I
R
R
I
D
L
K
S
L
N
N
V
R
I
K
N
E
R
L
L
C
F
Y
N
S
I
I
Y
N
G
K
V
L
S
N
D
T
Y
K
D
E
S
K
V
K
Y
Y
D
V
N
E
L
I
A
A
K
E
G
E
A
P
A
V
T
E
L
D
I
I
Q
K
Q
K
I
N
F
V
L
A
K
D
G
N
V
Y
T
L
E
S
A
D
N
G
C
N
I
V
K
I
K
N
D
F
T
L
E
K
V
F
A
N
F
Q
P
A
K
G
P
Y
H
S
S
P
T
I
G
M
V
A
S
E
T
E
N
I
I
Y
L
V
S
T
D
G
A
I
Y
K
Y
I
L
G
D
S
D
S
L
K
A
P
F
I
A
A
E
S
G
V
S
I
T
A
P
L
Q
L
N
Q
Q
S
G
E
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
I
V
V
Y
S
K
D
G
K
V
L
H
T
V
D
C
G
E
S
V
P
S
Q
I
L
F
N
N
65
89.34
100%
-60
- C- -
M065
-
A:
[28-552]
---------------------------
L
H
L
G
N
L
A
H
Y
P
N
V
L
K
G
T
F
P
T
E
S
Q
V
L
E
L
G
E
T
L
E
I
T
P
E
L
L
N
P
E
G
A
T
Y
S
W
L
V
N
G
K
E
Y
S
T
E
P
T
F
S
Y
K
I
D
N
P
C
R
A
D
L
S
C
I
I
K
N
K
Y
G
K
V
E
M
S
T
S
F
S
S
N
H
N
F
S
K
G
F
F
Y
V
A
D
G
T
F
N
F
Y
D
T
E
K
K
T
A
Y
Q
D
C
Y
A
S
L
N
A
G
K
T
L
G
I
G
N
Y
D
S
A
N
I
I
H
S
N
G
K
F
Y
L
L
V
G
T
S
T
S
N
R
D
H
F
Y
I
V
D
A
K
T
L
Y
Y
E
N
S
A
V
V
G
A
N
L
S
G
L
T
I
L
N
E
Q
Y
G
L
V
T
G
D
G
I
R
R
I
D
L
K
S
L
N
N
V
R
I
K
N
E
R
L
L
C
F
Y
N
S
I
I
Y
N
G
K
V
L
S
N
D
T
Y
K
D
E
S
K
V
K
Y
Y
D
V
N
E
L
I
A
A
K
E
G
E
A
P
A
V
T
E
L
D
I
I
Q
K
Q
K
I
N
F
V
L
A
K
D
G
N
V
Y
T
L
E
S
A
D
N
G
C
N
I
V
K
I
K
N
D
F
T
L
E
K
V
F
A
N
F
Q
P
A
K
G
P
Y
H
S
S
P
T
I
G
M
V
A
S
E
T
E
N
I
I
Y
L
V
S
T
D
G
A
I
Y
K
Y
I
L
G
D
S
D
S
L
K
A
P
F
I
A
A
E
S
G
V
S
I
T
A
P
L
Q
L
N
Q
Q
S
G
E
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
I
V
V
Y
S
K
D
G
K
V
L
H
T
V
D
C
G
E
S
V
P
S
Q
I
L
F
N
N