@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T0826: (2014-06-19 )
MIKPNLRPKLGSSALIAFLSLYSSLVLNYAFFAKVVELHPFNGTGADIFLYTMPVVLFFLSNFVFHVIALPFVHKVLIPLILVISAAVSYQEIFFNIYFNKSMLNNVLQTTAAESARLITPGYVLWIVCLGVLPALAYIAVKVKYRVWYKELLTRLVLAAVSFLCALGIAMLQYQDYASFFRNNKSVTHLIVPSNFIGAGVSKYKDWKRSNIPYTQLDMAVVQNRPAGSLRRFVVLVVGETTRAANWGLNGYSRQTTPLLAARGDEIVNFPQVRSCGTSTAHSLPCMFSTFDRTDYDEIKAEHQDNLLDIVQRAGVEVTWLENDSGCKGVCGKVPNTDVTSLNLPEYCRNGECLDNILLTKFDEVLNKNDKDAVLILHTIGSHGPTYYERYTEAERKFTPTCDTNEINKCTRATLVNTYDNTVLYVDQFIDKVIRKLENRDDLESVVHYVSDHGESLGENGMYLHAAPYAIAPSGQTHIPMVMWFSKAFRQHGGIDFQCLKQKAAENEYSHDHYFSTVLGLMDISNSQTYRKEMDILAACRRPR
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........--------10........20......----..30........40..------------......50........60.---.......70........80----------.........--90........100.......110......------.120.---......130.-------------------......140.......150.......160--------.........170-----------.......180.......190.........200.......210.--......220...----...--.230-----..----------------...---------..240......------.--------250---........---.260-.---........-270..-.-.-.-.-.280.....------------------------------------..290------------.-.-.------------.----------.-.---------------.-------------------------.300-------------.---------------........310..-...-----------------------.---.320.-----------.-------------------------------.-..-----..-----.-----------------------330------.-------.-------------------------.---------..-------.---------.-----.--------.----340---....---..-.----------..-----------------------------350-----.-........360--------.......---.-----370..--.------------------......380....-----...390....----------.-----..400----------...--------.-.-------.----------------..410......--.420.......430.......440-.-.------.....450..------------...-----.-.460-.-----...--...-..470--....--.....480.....--.----.490.......500.......--------------------------------510------------------------------.--........520.....----..530.......540..-----------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIKPNLRPK--------L
G
S
S
A
L
I
A
F
L
S
L
Y
S
S
L
V
L
----
N
Y
A
F
F
A
K
V
V
ELHPFNG------------TGA
D
I
F
L
Y
T
M
P
V
V
L
F
F
L
S
N
---
F
V
F
H
V
I
A
L
P
F
V
H
K
V
L
I
P
L
-----------
I
L
V
I
S
A
A
V
S
--
Y
Q
E
I
F
F
N
I
Y
F
N
K
S
M
L
N
N
V
L
Q
T
T
AAES
A
R
L------IT
P
G
Y
---
V
L
W
I
V
C
L
G
V
L
-------------------
P
A
L
A
Y
I
A
V
K
V
K
Y
R
V
W
Y
K
E
L
L
T
R
L
V
L
A
A
----------
V
S
F
L
C
A
L
G
I
A
M
L
-----------
Q
Y
Q
D
Y
A
S
F
F
RNNK
S
V
T
H
L
--
I
VPSNFIG
A
G
V
S
K
Y
K
DWKRSNI
P
--
Y
T
Q
L
D
M
A
V
VQNR----PAG--S
L
R
R
-----
F
V
----------------
V
L
V
---------VGETTR
A
A
NWG------L--------N-----GYSRQTT
P
---
L
L
---A---ARGDEIVN-
F
P
Q
V
R-S-C-G-T-STAHSLP
C
M
------------------------------------
F
S
TF-------------D-R-T------------
D
----------
Y
-
D
---------------
E
-------------------------
I
K
---------------
A
---------------EHQ
D
N
L
L
D
I
V
Q
RA-G
V
E
-----------------------
V
---
T
W
L-E-----------N-------------------------------D-SG-----CK-----G-----------------------V--------C-------G-------------------------K---------VP-------N---------T-----D--------V----T-----SLN
L
---
P
E
-
Y
----------CR-----------------------------N-------
G
-
E
C
L
D
N
I
L
L
T
K
---------
F
D
E
V
LNK---N-----D--K
D
--
A
------------------
V
L
I
L
H
TIGSHG
P
T
-----
Y
Y
E
R
Y
T
E
A
ER----------K-----FTPT-----------CD
T
--------
N
-
E
-------
I
----------------
N
K
C
T
R
A
T
L
V
NT--YD
N
T
V
L
Y
V
D
Q
F
I
D
K
V
I
R
K
LE
N
R
D
D
-
L
-
E
------
S
V
V
H
Y
V
S
DHG------------ESL-----G-EN---
G
-----
M
Y
L
--HAA-P
Y
A
----IAPS--GQTH
I
P
M
V
M
W
F
S
K
--
A
----
F
R
QHGGI
D
F
Q
C
L
K
Q
K
AAENEY--------------------------------S--------------------------------
H
--
D
H
Y
F
S
T
V
L
G
L
MDISN
S
----
Q
T
Y
R
K
E
M
D
I
L
A
A
CRRPR-----------------------------------------------------------------------
22
Fugue
83.32
15%
-90
- C4 -
2W62
1
GAS2_YEAST
A:
[29-489]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
E
K
T
P
A
I
K
I
V
G
N
K
F
F
DSES
G
E
Q
F
F
I
K
G
I
A
Y
Q
L
Q
R
S
------------
G
A
F
E
T
S
Y
I
D
------
A
L
A
D
---
P
K
I
C
L
R
D
I
P
F
L
K
M
L
G
V
N
T
-----------
L
R
V
-------------
Y
A
I
D
P
T
K
S
H
---------
D
I
C
M
E
A
------
L
S
A
E
G
---
M
Y
V
L
L
D
L
S
E
P
-------------------
D
I
----
S
I
N
R
E
N
P
S
W
D
V
H
I
F
E
R
Y
K
S
V
I
----------
D
A
M
S
-------------------
S
F
P
N
L
L
G
Y
F
A
G
N
E
V
T
N
D
H
TN
T
F
A
S
P
F
V
K
A
A
I
R
D
A
K
E
Y
I
S
H
S
-
N
--
H
R
K
I
P
V
G
Y
S
T
N
D
----
D
A
M
--
T
R
D
N
-----
L
A
----------------
R
Y
F
---------
V
C
G
D
V
K
A
D
F
Y
G
------
I
--------
N
MYEWC
G
Y
S
T
Y
G
T
S
---
G
Y
---
R
---
E
R
T
K
E
F
E
G
-
Y
P
-----------------
I
P
V
F
------------------------------------
F
S
E
F
G
C
NLV--------
R
-
P
-
R
------------
P
----------
F
-
T
---------------
E
-------------------------
V
S
---------------
A
---------------
L
Y
G
N
K
M
S
S
-
V
W
S
G
-
G
L
A
-----------------------
Y
---
M
Y
F
-
E
-----------
E
-------------------------------
E
-
N
E
------
Y
-----
G
-----------------------
V
--------
V
-------
K
-------------------------
I
---------
N
D
-------
N
---------
D
-----
G
--------
V
----
D
-----
I
L
P
-----------------------------------------------------------------
D
F
K
N
---------
L
K
K
E
F
A
K
---
A
-----
D
--
P
K
--
G
------------------
I
----
T
E
E
E
Y
L
T
E
-----
S
V
E
C
P
H
I
A
V
G
----------
V
-----
W
E
A
N
-----------
E
K
L
--------
P
-
E
-------
T
----------------
P
D
R
S
K
C
A
C
L
D
E
--
I
L
P
C
E
I
V
P
F
G
K
Y
E
E
Y
F
S
Y
L
C
S
K
V
D
-
C
-
S
------
D
I
--------------------
L
A
N
-----
G
-
K
T
---
G
-----
E
Y
-----
G
-
E
F
S
----
D
C
S
-----
V
E
Q
K
L
S
L
Q
L
S
K
--
L
----
Y
C
K
I
G
A
N
D
R
H
C
P
------------------------------------------------------------------------------------------
L
N
D
----
K
N
V
Y
F
N
L
E
S
L
Q
P
C
---------------------------------------------------------------------------
39
HHSearch
75.28
18%
-56
- C4 -
2W5Q
1
LTAS_STAAW
A:
[31-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
----------------
I
K
I
---------
H
L
E
S
F
Q
T
F
L
I
N
------
K
--------
K
-----
V
N
G
K
E
V
T
P
---
F
L
N
K
L
S
---
S
G
K
-
E
Q
F
T
Y
F
P
N
F
F
-
H
-
Q
T
G
-
Q
G
K
T
S
D
S
E
F
T
M
------------------------------------
D
N
S
L
Y------------
G
-
L
-
P
------------
Q
GS--------
A
F
S
---------------
L
-------------------------
K
G
---------------
D
---------------
N
T
Y
Q
S
L
P
A
I
L
D
Q
K
Q
G
Y
K
-----------------------
S
---
D
V
M
-
H
-----------
G
-------------------------------
D
-
Y
-------
K
-----
T
-----------------------
F
--------
W
-------
N
-------------------------
R
D
Q
-------
V
Y
K
H
F
GIDK
F
---------
Y
-----
D
--------
A
----
T
-----
Y
Y
D
M
---
S
D
K
N
----------
V
V
-----------------------------
N
-------
L
-
G
L
K
D
K
I
F
F
K
D
---------
S
A
N
Y
Q
A
K
---
M
-----
K
--
S
P
--
F
------------------
Y
S
H
L
I
T
L
T
N
H
Y
P
F
-----
T
---
L
D
E
K
D
A
----------
T
-----
I
E
K
S
-----------
N
----------------------------------------
T
G
D
A
T
V
D
G
--
Y
I
Q
T
A
R
Y
L
D
E
A
L
E
E
Y
I
N
D
L
K
K
K
G
L
Y
D
-
N
------
S
V
I
M
I
Y
G
D
H
Y
------------
G
I
S
-----
E
N
H
N
N
A
M
E
-----
K
L
L
GE
K
I
T
-
P
A
K
----
F
T
----
D
L
N
R
T
G
F
W
I
K
I
P
G
--------
K
-
S
-
G
--------
G
I
N
N
E
Y
A
--------------------------------
G
--------------------------------
Q
--
V
D
V
M
P
T
I
L
H
L
A
G
I
D
T
K
----
N
Y
L
M
F
G
T
D
L
F
S
K
----------------------------------------------------------------------------
37
HHSearch
73.78
17%
-71
- C4 -
3LXQ
-
?
A:
[84-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
K
N
------
L
----------------
V
I
L
---------
L
Q
E
S
L
G
A
Q
F
V
G
------
S
--------
L
-----
G
G
L
-
P
L
T
P
---
N
L
---
D
---
E
L
M
Q
E
G
W
Q
-
F
T
Q
M
Y
-
A
-
T
-
G
-
T
-
R
S
V
R
G
I
E
A
V
------------------------------------
T
T
G
F
-------------
P
-
P
-
S
------------
P
----------
S
-
R
AVVKL----------
S
-------------------------
K
S
---------------
Q
---------------
T
G
F
F
T
I
A
D
L
L
K
E
Q
-
G
Y
H
-----------------------
T
---
Q
F
I
Y
G
-----------
G
-------------------------------
E
-
A
N
-----
F
D
-----
N
-----------------------
M
K
T
F
F
F
G
N
G
F
-------
D
-------------------------
Q
---------
I
------------------
V
-----
E
--------
E
----
K
-----
N
Y
T
N
---
P
G
-
F
----------
V
G
-----------------------------
S
-------
W
-
G
V
S
D
E
D
L
Y
N
K
---------
A
D
E
E
F
E
R
L
S
K
G
-----
D
--
K
P
--
F
------------------
F
S
L
V
F
T
S
S
N
H
S
P
Y
-----
E
---
Y
P
E
G
K
I
----------
E
-----
Q
Y
D
S
--------------------------------------------------------
E
H
M
T
--
R
N
N
A
V
K
Y
S
D
Y
A
L
G
T
F
F
D
K
A
K
K
S
S
Y
-
W
D
D
------
T
I
F
I
V
I
A
D
H
D
------------
A
R
V
-----
F
-
G
A
---
N
---------------------
L
V
P
V
--
K
H
F
H
I
P
A
L
I
I
G
-
K
--
D
----
I
Q
P
--
R
---------
K
D
D
R
I
A
--------------------------------
N
--------------------------------
N
--
I
D
M
P
P
T
L
L
S
L
I
G
V
D
-
A
----
K
T
P
M
I
G
R
D
L
T
K
P
----------------------------------------------------------------------------
35
HHSearch
73.28
16%
-55
* C4 *
3B5Q
10
?
A:
[15-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
N
------
F
----------------
L
I
I
---------
Q
C
D
H
L
T
Q
R
V
V
G
------
A
--------
Y
-----
G
Q
T
Q
G
C
T
L
P
I
D
E
V
---
A
---
S
R
G
---
V
I
-
F
S
N
A
Y
-
V
-
G
-
C
-
P
-
L
S
Q
P
S
R
A
A
L
------------------------------------
W
S
G
M
-------------
M
P
H
-
Q
------------
T
NVRS------
N
-
S
S--------------
E
PVNT---------------------
R
L
---------------
P
---------------
E
N
V
P
T
L
G
S
L
F
S
E
S
-
G
Y
E
-----------------------
A
---
V
H
F
-
G
-----------
K
-------------------------------
T
-
H
D
------------
M
------------------------------------------------------------------
G
---------
S
L
-------
R
G--------
F
-----
K
--------
H
----
K
E
P
V
A
K
P
F
T
D
---
P
E
-
F
----------
P
V
-----------------------------
N
-------
N
D
S
F
L
D
V
G
T
C
E
D
---------
A
V
A
Y
L
S
N
---
P
P----
K
--
E
P
--
F
------------------
I
C
I
A
D
F
Q
N
P
H
N
I
C
G
F
I
G
E
N
A
G
V
H
T
D
R
P
I
----------
S
GPLPE
L
P
D
N
-----------
F
D
V
--------
E
-
D
WSNIP
T
P
V
Q
Y
I
CCSH
R
R
M
T
Q
A
A
HW
N
E
E
N
Y
R
H
Y
I
A
A
--
F
Q
H
Y
T
K
M
V
S
K
Q
V
D
S
V
L
K
A
L
Y
S
T
P
A
G
R
-
N
------
T
I
V
V
I
M
A
D
H
G
------------
D
G
M
-----
A
-
S
H
---
R
-----
M
V
T
--
K
H
I
S
F
Y
--------
D
--
E
M
T
N
V
P
F
I
F
A
G
P
G
--
I
----
K
Q
Q
----------
K
K
P
V
D
H
L
L
--------------------------------
T
--------------------------------
Q
PT
L
D
L
L
P
T
L
C
D
L
A
G
I
A
----------------------------------------------------------------------------------------------
15
Fugue
71.84
13%
-51
- C3 -
4EEI
10
?
A:
[1-433]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
R
Y
D
V
A
E
--------
I
--
S
K
I
W
A
D
E
N
K
Y
A
K
M
L
E
----
V
E
L
A
I
L
E
A
L
E
D
R
M
V
P
K
------------
G
T
A
A
E
I
R
A
R
A
Q
-------------
I
R
P
E
R
V
D
E
I
E
K
V
T
K
H
D
-----------
I
I
A
F
C
T
S
I
A
---------------------
E
Q
F
T
A
E
T
G
K
F
------
F
H
F
G
V
---
T
-------------------------------
S
S
D
I
I
D
S
A
L
S
L
Q
I
R
D
S
M
S
Y
V
I
K
D
L
----------
E
A
L
C
D
S
L
L
T
K
A
E
-----------
E
T
K
E
I
I
T
M
G
R
S
H
G
---
M
F
--
A
E
P
M
S
F
G
Q
K
F
L
G
A
Y
V
E
F
K
R
R
L
K
D
--
L
K
D
F
Q
K
D
G
L
T
V
Q
----
F
S
G
--
A
V
G
N
-----
Y
C
----------------
I
L
T
---------
T
E
D
E
K
K
A
A
D
I
L
---------------------
G
L
P
V
E
E
V
S
---
T
Q
---
V
---
I
P
R
D
R
I
A
K
-
L
I
S
I
H
-
G
-
L
-
I
-
A
-
S
A
I
E
R
L
A
V
E
------------------------------------
I
R
H
L
-------------
H
-
R
-
S
------------
D
----------
V
-
F
---------------
E
-------------------------
V
Y
---------------
E
---------------
G
F
K
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
S
T
---
E
N
-
L
----------
T
G
-----------------------------
M
-------
A
-
R
M
L
R
S
H
V
S
I
A
---------
L
E
N
C
V
L
W
---
H
-----
E
--
R
D
--
I
---------------------------------------
S
H
S
S
A
E
R
----------
F
-----
Y
L
P
-------------
D
N
--------
F
-
G
-------
I
----------------
M
V
Y
A
L
R
R
M
K
N
T
--
I
D
N
L
V
V
Q
-
R
D
I
I
E
D
R
V
R
S
T
S
A
----------------
Y
L
S
S
F
Y
L
------------
H
F
L
-----
V
-
A
N
---
T
-----
P
F
M
--
R
E
D
-
C
Y
K
----
I
V
Q
Q
--
V
E
S
---
F
S
K
K
L
Q
K
--
V
----
M
H
D
E
H
N
I
I
L
D
I
P
E
M
D
F
E
G
I
K
K
--------------------------------
T
--------------------------------
Y
--
L
----------------------
K
E
I
D
H
V
F
D
R
S
V
K
A
R
-----------------------------------------------------------------------
43
HHSearch
70.81
15%
-70
- C4 -
3ED4
3
?
A:
[27-377]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
N
------
L
----------------
V
I
I
---------
M
A
D
D
L
G
Y
G
D
L
A
------
T
--------
Y
-----
G
H
Q
I
V
K
T
P
---
N
I
D
R
L
A
---
Q
E
G
---
V
K
-
F
T
D
Y
Y
-
A
-
P
-
A
-
P
-
L
S
S
P
S
R
A
G
L
------------------------------------
L
T
G
R
-------------
M
-
P
-
F
------------
R
TGIR
S
W
I
P
S
G
K
-
D
---------------
V
-------------------------
A
L
---------------
G
---------------
R
N
E
L
T
I
A
N
L
L
K
A
Q
-
G
Y
D
-----------------------
T
---
A
M
M
-
G
-----------
K
LHLN---------------------------
A
G
G
D
-----
R
T
-----
D
-----------------------
Q
--------
P
QAQDMGF
D
YSLANTAG-----------------
F
---------
V
T
-------
D
A
T
L
D
N
AKER
P
-----
R
--------
Y
----
G
-----
M
V
Y
P
---
T
G
-
W
----------
L
R
-----------------------------
N
G
Q
P
T
P
RA
D
-
K
M
S
G
E
Y
V
S
S
E
---------
V
V
N
W
L
D
N
---
K
-----
K
DS
K
P
--
F
------------------
F
L
Y
V
A
F
T
E
V
H
S
P
L
A
S
P
K
K
Y
L
D
M
Y
S
Q
Y
M
S
A
Y
Q
-------
K
-----
Q
H
P
D
-----------
L
F
Y
--------
G
-
D
-------
W
----------------
A
-
D
K
P
W
R
G
V
G
E
--
Y
Y
A
N
I
S
Y
L
D
A
Q
V
G
K
V
L
D
K
I
K
A
M
G
E
E
D
-
N
------
T
I
V
I
F
T
S
D
N
G
PVTREARKVYEL
N
L
A
-----
G
-
E
T
---
D
-----
G
L
R
GR
K
D
N
-
L
W
--------
E
--
G
G
I
R
V
P
A
I
I
K
Y
G
K
--
H
----
L
P
Q
----------
G
M
V
S
D
T
P
V
--------------------------------
Y
--------------------------------
G
--
L
D
W
M
P
T
L
A
K
M
M
N
F
K
----------------------------------------------------------------------------------------------
33
SP3
70.79
7%
-92
- C4 -
1EQJ
1
GPMI_GEOSE
A:
[3-510]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K
K
P
V
A
L
I
I
LDG
F
A
L
R
DETYGNAVAQANK
P
N
F
D
R
Y
W
N
E
Y
P
H
T
T
L
K
ACGEAVGLPEGQMGN
S
E
V
G
H
L
N
I
G
A
GRI
V
Y
Q
S
L
T
R
I
N
--------
I
A
I
R
E
---------
G
E
F
D
----
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
------------
T
S
-----------------------------------
L
H
L
-----------
F
G
L
L
S
D
G
----------
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
K
---------------
R
V
Y
I
H
G
F
-------------------------------
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
----------
Q
E
K
I
K
E
Y
G
V
G
E
I
A
T
L
S
G
RYYSMD
R
D
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
--
E
G
P
T
Y
--
R
D
P
L
E
C
I
E
D
S
Y
K
H
G
I
Y
--
D
E
F
V
L
P
S
V
I
V
R
E
----
D
G
R
--
P
V
A
T
IQDN
D
A
I
----------------
I
F
Y
NFRPDRA
I
Q
I
S
N
T
F
T
N
E
D
F
R
------
E
--------
F
-----
D
R
G
P
K
H
P
K
---
H
L
---
F
--------
F
V
C
-
L
T
H
F
--------------------------------------------------------
S
E
T
-------------
V
-
A
-
G
------------
Y
----------
V
-
A
---------------
F
-------------------------
K
P
---------------
T
---------------
N
L
D
N
T
I
G
E
V
L
S
Q
H
-
G
L
R
-----------------------
Q
---
L
R
I
-
A
-----------
E
TEKYPHVTFFM--------------------
S
-
G
G
-----
R
E
-----
E
-----------------------
E
--------
F
-------
P
-------------------------
G
---------
E
D
-------
R
---------
I
-----
L
--------
I
----
N
-----
S
P
K
V
---
P
T
-
Y
----------
D
L
-----------------------------
K
-------
P
-
E
M
S
A
Y
E
V
T
D
A
---------
L
L
K
E
I
E
A
---
D
-----
K
--
Y
D
---------------------
A
I
I
L
N
Y
A
N
P
------------------
D
----------
M
-----
V
G
H
S
-----------
G
K
--------------------------------------------
L
E
P
--
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
K
G
G
-----------
I
A
I
I
T
A
D
H
G
------------
N
A
-------------
D
-----
E
V
L
--
T
P
D
-
G
K
P
----
Q
T
A
H
--
T
T
N
P
V
P
V
I
V
T
K
K
G
--
I
-------------------
K
L
R
D
G
G
--------------------------------
I
--------------------------------
L
--
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
----
K
E
M
T
-
G
K
S
L
I
V
-----------------------------------------------------------------------------
16
Fugue
69.84
15%
-64
- C3 -
3W3W
-
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
VQDDLPAW
P
E
L
L
Q
A
L
I
E
S
L
K
SGN
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
VD
I
N
S
I
L
P
I
F
Q
S
G
F
T
DAS
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
LPKSEWSKLGIL
L
P
S
L
L
N
S
L
P
R
F
L
D
D
GK
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
APKLFKDM
F
D
Q
I
I
Q
F
T
D
M
V
I
K
NKDLEP
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
EVSIDDDDA
A
E
W
I
E
SDDTDDEEE
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
LGGEYL
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
STE
W
R
E
R
F
A
A
M
M
A
L
S
S
A
AEGCA
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
NDPH
P
R
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
S
P
F
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
--------
L
T
S
E
C
T
S
R
V
Q
T
H
A
A
A
A
L
V
----
N
F
S
E
F
A
S
K
D
I
L
E
P
Y
L
D
------------
S
L
L
T
N
L
L
V
L
L
Q
S
N
K
L
Y
V
Q
E
---
Q
A
L
T
T
I
A
F
-
I
A
E
A
A
K
------------------
N
K
F
I
K
--
Y
Y
D
T
L
M
P
L
L
L
N
V
L
K
V
N
S
V
L
K
G
K
C
M
E
C
A
T
L
------
I
G
F
A
V
G
K
E
K
F
H
E
H
S
Q
E
L
I
-------------------
S
I
L
V
A
L
Q
N
S
D
A
L
R
S
Y
L
E
Q
S
W
S
R
I
C
R
I
L
G---------
D
D
F
V
P
L
L
P
I
V
I
P
-----------
P
L
L
I
T
A
----
K
A
T
Q
D
V
G
L
--
I
E
E
E
E
--
A
A
N
F
Q
Q
Y
P
D
W
D
V
V
Q
V
Q
G
K
H
I
A
I
H
T
S
V
L
D
D
K
----
V
S
A
M
E
L
L
Q
S
-----
Y
A
----------------
T
L
L
---------
R
G
Q
F
A
V
Y
V
K
E
V
------
M
--------
E
-----
E
I
A
L
P
S
L
D
---
F
Y
LH
D
G
---
V
R
A
A
G
A
T
L
-
I
P
I
L
L
-
S
-
C
-
L
-
L
-
A
-
A
E
E
L
V
L
L
------------------------------------
W
H
K
A
-------------
S
-
S
-
K
------------
L
----------
I
-
G
---------------
G
-------------------------
L
M
---------------
S
---------------
E
P
M
P
E
I
T
Q
V
Y
H
N
S
-
L
V
N
-----------------------
G
---
I
K
V
-
M
-----------
G
-------------------------------
D
-
N
C
-----
L
S
-----
E
-----------------------
D
--------
Q
-------
L
-------------------------
A
---------
A
F
-------
T
---------
K
-----
G
--------
V
----
S
-----
A
N
L
T
---
D
T
-
Y
----------
E
R
-----------------------------
M
-------
Q
-
D
R
D
E
Y
N
E
D
F
T
---------
D
E
D
L
L
D
E
---
I
-----
N
--
K
S
--
I
------------------
A
A
V
L
K
T
T
N
G
H
--------
Y
L
K
N
L
E
N
I
W
P
----------
M
-----
I
N
T
F
-----------
L
L
E
--------
P
-
I
-------
L
----------------
V
I
F
A
L
V
V
I
G
D
L
I
Q
Y
E
Q
T
A
S
M
K
N
A
F
I
P
K
V
T
E
C
L
I
S
P
D
---------------------------------
A
R
I
-----
R
-
Q
A
---
A
-----
S
Y
I
--
I
G
V
-
C
A
Q
----
Y
A
P
S
TY
A
D
V
C
I
P
T
L
D
T
L
V
Q
--
I
----
V
D
----------
G
S
K
L
E
E
N
R
S
--------------------------------
S
--------------------------------
T
--
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
N
S
NIPD
T
Y
T
A
N
W
F
K
T
L
P
T
I
T
D
K
E
A
A
S
F
N
Y
Q
F
L
S
QVCAQSN
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
RSLT
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F
40
HHSearch
65.07
15%
-68
- C4 -
2W8D
2
LTAS2_BACSU
A:
[33-340]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
----------------
I
Y
V
---------
S
L
E
S
L
Q
S
F
I
I
D
------
Y
--------
K
-----
I
D
G
K
E
V
T
P
F
L
N
K
L
---
A
---
H
D
N
-
E
T
F
Y
-
F
D
N
F
F
-
H
-
Q
T
G
Q
G
-
K
T
S
D
A
E
F
M
M
------------------------------------
E
N
S
L
Y------------
P
-
L
-
A
------------
Q
GSV-------
F
-
V
---------------
N
-------------------------
K
A
---------------
Q
---------------
N
T
L
Q
S
V
P
A
I
L
K
S
K
-
N
Y
T
-----------------------
S
---
A
T
F
-
H
-----------
G
-------------------------------
N
-
T
Q
-----
T
F
W----
N
R
N
E
M
Y
K
A
E---------------
G
--------
I
-------
D
-------------------------
K
---------
F
F
-----------------------
D
--------
S
----
A
-----
Y
Y
D
M
---
N
E
E
N
----------
T
K
-----------------------------
N
-------
Y
-
G
M
K
D
K
P
F
F
K
E
---------
S
M
P
L
L
E
S
---
L
-----
P
--
Q
P
--
F
------------------
Y
T
K
F
I
T
L
S
N
H
F
P
F
-----
G
---
M
D
E
G
D
T
----------
D
-----
F
P
A
G
-----------
D
----------------------------------------
F
G
D
S
V
V
D
N
--
Y
F
Q
S
A
H
Y
L
D
Q
S
I
E
Q
F
F
N
D
L
K
K
D
G
L
Y
D
-
K
------
S
I
I
V
M
Y
G
D
H
Y
------------
G
I
S
-----
E
-
N
H
---
N
K
A
M
A
K
V
L
G
KD
E
I
T
-
D
Y
D
----
N
--
A
--
Q
L
Q
R
V
P
L
F
I
H
A
A
G
-------
V
-
K
--
G
--------
E
K
V
H
K
Y
A
--------------------------------
G
--------------------------------
D
--
V
D
V
A
P
T
I
L
H
L
L
G
V
D
T
K
----
D
Y
L
M
S
G
S
D
I
L
S
K
E
H
--------------------------------------------------------------------------
21
Fugue
64.15
11%
-79
- C1 -
3P5P
5
TASY_TAXBR
A:
[5-756]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
Y
Q
E
R
A
D
E
L
V
V
K
I
K
D
M
F
N
A
L
GD
G
D
I
S
PS
A
Y
D
T
A
W
V
A
R
L
A
T
I
S
S
D
G
S
----
E
K
P
R
F
P
Q
A
L
N
W
V
F
N
N
Q
LQDGSWGIESHF
S
L
C
D
R
L
L
N
T
T
N
S
V
I
A
L
S
V
W
KTG
H
S
Q
V
Q
Q
G
A
E
F
I
A
E
N
L
R
L
L
NEEDELSPDFQ
I
I
F
P
A
L
L
Q
K
--
A
K
A
L
G
I
N
L
P
Y
D
L
P
F
I
K
Y
L
S
T
T
R
E
A
R
L
T
D
V
S
A
AADN
I
P
A
N
M
---
L
N
A
L
E
G
L
E
E
V
IDWNKIMRFQSKDGSFLSS
P
A
S
T
A
C
V
L
M
N
T
G
D
E
K
C
F
T
F
L
N
N
L
L
D
K
F
GGCVPCMYSI
D
L
L
E
R
L
S
L
V
D
N
I
-----------
E
H
L
G
I
G
R
H
F
K
Q
E
I
K
G
A
L
D
--
Y
V
Y
R
H
W
S
E
R
G
I
G
W
G
R
D
S
L
V
P
D
L
N
--
T
T
A
L
G
L
R
T
L
R
M
H
GYNV
S
S
D
--
V
L
N
N
-----
F
K
DENGRFFSSAGQTHVE
L
R
S
---------
V
V
N
L
F
R
A
S
D
L
A
FPDE
R
A
M
--------
D
-----
D
A
R
K
F
A
E
P
---
Y
L
---
R
---
E
A
L
A
T
K
I
S
-
T
N
T
K
L
-
F
-
K
-
E
-
I
-
E
Y
V
V
E
Y
P
W
H
MSI
P
R
L
E
A
R
S
Y
I
D
S
YDDN
Y
V
W
Q
R
K
T
L
Y
R
MPSLSN
S
K
C
L
E
L
-------------
A
-
K
-
L
------------
D
----------
F
-
N
---------------
I
-------------------------
V
Q
---------------
S
---------------
L
H
Q
E
E
L
K
L
L
T
R
W
W
-
K
E
----------------------------
S
G
M
-
A
-----------
D
-------------------------------
I
-
N
F
-----
T
R
-----
H
-----------------------
R
--------
V
-------
A
-------------------------
E
---------
V
Y
-------
F
---------
S
-----
S
--------
A
----
T
-----
F
E
P
E
---
Y
S
-
A
----------
T
R
-----------------------------
I
-------
A
-
F
T
K
I
G
C
L
Q
V
L
---------
F
D
D
M
A
D
I
FA-
T
-----
L
--
D
E
--
L
------------------
K
S
F
T
E
G
V
K
R
W
D
T
S
-----
L
L
H
E
I
P
E
C
M
Q
----------
T
-----
C
F
K
V
-----------
W
F
---------
K
-
L
-------
M
----------------
E
E
V
N
N
D
V
V
K
V
Q
--
G
R
D
M
L
A
H
I
R
K
P
W
E
L
Y
F
N
C
Y
V
Q
E
R
E
-
W
-
L
E
A
G
Y
I
P
T
F
E
E
Y
L
K
T
Y
A
------------
I
S
V
-----
G
-
L
G
---
P
-----
C
T
L
--
Q
P
I
-
L
L
M
----
G
E
L
V
--
K
D
D
V
V
E
K
V
H
Y
P
S
N
--
M
----
F
E
L
V
S
L
S
W
R
L
T
N
D
T
K
T
Y
Q
A
E
K
--------------------------------
A
--------------------------------
R
--
G
Q
Q
A
S
G
I
A
C
Y
M
K
D
N
P
G
----
A
T
E
E
D
A
I
K
H
I
C
R
V
V
D
R
A
L
K
E
A
S
F
E
Y
F
KPSNDIP
M
G
C
K
S
F
I
F
N
L
R
L
C
V
Q
I
F
YKFNEE
I
K
D
Y
I
R
K
V
YIDPIQV-----------------
18
Fugue
54.78
10%
-65
- C4 -
3OYZ
2
?
A:
[5-432]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
D
R
E
F
V
R
T
--------
F
F
T
S
P
T
-----
A
V
E
G
E
D
D
----
S
A
K
M
L
R
R
A
A
G
L
R
G
M
Q
A
--------------
P
D
V
W
V
P
D
N
E
--------------
D
A
T
A
P
S
M
R
D
E
G
A
E
N
I
-----------
V
E
V
I
S
E
Q
G
A
EF
P
G
E
I
H
P
R
M
V
W
H
R
D
--
S
P
E
T
R
Y
Q
G
F
Q
H
M
L
D
------
I
T
D
-----------------------------------
P
E
R
G
A
V
E
H
I
H
G
F
V
I
P
E
V
G
G
I
D
D
W
K
K
A
----------
D
E
F
F
T
I
V
E
H
E
H
G
-----------
L
--------
D
E
G
S
L
A
M
S
V
--
I
I
E
S
---------------
G
E
A
E
--
L
A
M
G
D
L
R
D
E
M
G
K
----
P
T
N
--
N
L
E
R
-----
L
F
----------------
L
L
V
---------
D
G
E
V
D
Y
T
K
D
M
R
------
A
--------
M
-----
T
P
T
G
E
L
P
A
---
W
P
---
E
---
L
R
H
N
T
S
R
----
G
A
S
-
A
-
A
-
G
-
C
-
V
A
V
D
G
P
Y
D
D
------------------------------------
I
R
---------------
D
-
V
-
E
------------
G
----------
Y
-
R
---------------
E
-------------------------
R
M
---------------
T
---------------
D
N
Q
A
--------------------------------------------------------------------------------------------------
K
-----
G
-----------------------
M
--------
L
-------
G
-------------------------
I
---------
W
S
-----------------------------------------------------------------------------------------------------------
L
T
P
G
Q
V
V
E
---------
A
N
T
S
P
L
P
---
P
-----
K
--
T
G
--
S
--------------------------
W
L
L
D
A
-----
D
E
L
R
E
E
L
L
G
L
----------
T
-------------------------------------------------------------------------
S
Y
V
P
S
M
D
D
I
V
D
S
M
E
E
F
E
A
A
K
E
A
-
G
-
R
------
G
A
I
A
M
T
Q
S
A
T
------------
I
E
K
-----
D
-
R
M
---
W
-----
D
E
A
--
T
Y
Q
-
A
A
----------------
M
T
P
I
S
L
F
Q
--
D
----
V
Y
E
N
---------
R
P
D
Q
H
E
E
L
--------------------------------
E
--------------------------------
E
--
R
Y
G
A
G
V
V
E
R
A
M
E
V
G
----------------------------------------------------------------------------------------------
56
HHSearch
51.33
16%
-47
- C4 -
3Q3Q
3
ALPH_SPHSX
A:
[37-358]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
T
P
P
K
-----
L
I
----------------
V
A
I
---------
S
V
D
Q
F
S
A
D
L
F
S
------
E
--------
Y
-----
R
Q
Y
--
Y
T
G
---
G
L
---
K
R
L
T
S
E
G
---
A
V
-
F
P
R
G
Y
Q
S
H
A
-
A
-
T
-
E
T
C
P
G
H
S
T
I
------------------------------------
L
T
G
S
-------------
R
P
S
-
R
TGIIANN-----
W
----------
F
-
D
LDA------------
K
REDKNLYCAEDESQPGSSSD
K
Y
E
A
S
P
L
---------------
H
---------------
L
K
V
P
T
L
G
G
R
M
K
A
A
-
N
P
A
T
R
V
V
S
V
A
GK
D
R
A
A
I
M
M
G
GATAD
Q
V
---
W
W
L
-
G
-----------
G
-------------------------------
P
-
Q
-------------
G
-----------------------
Y
--------
V
SYKG---
V
-------------------------
A
---------
P
T
-------
P
L
V
T
Q
-----
V
N
Q
A
F
A
Q
--------
R
----
L
A
QPNP
G
F
E
L
---
P
A
-
Q
----------
C
V
SK
D
F
P
V
Q
A
GNRTVGTGRFARDAGD
Y
K
G
F
R
I
-------
S
-
P
E
Q
D
A
M
T
L
A
F
---------
A
A
A
A
I
E
N
---
M
QLGKQ
A
--
Q
T
--
D
------------------
I
I
S
I
G
L
S
A
T
D
Y
V
G
-----
H
--
T
----------------------
F
G
T
-------------
E
---------------------------------------
G
-----
T
E
--
S
C
I
Q
V
D
R
L
D
T
E
L
G
A
F
F
D
K
L
D
K
D
G
I
---
D
------
Y
V
V
V
L
T
A
D
H
G
------------
G
H
D
-----
L
-
P
E
---
R
-----
H
R
M
--
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
50.55
15%
-50
- C4 -
2GSO
-
?
A:
[6-225]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
-----
A
L
----------------
L
L
I
---------
S
I
D
G
L
R
A
D
M
L
D
------
R
------------------
G
I
T
P
---
N
L
S
H
L
A
---
R
E
G
---
V
R
-
A
R
W
M
A
-
P
-
S
-
Y
P
S
-
L
T
F
P
N
H
Y
T
L
------------------------------------
V
T
G
L
-------------
R
P
D
-
H
HGIVHN
S
-----
M
----------
R
-
D
---------------
P
-------------------------
T
L
GGFWLSK
S
E
A
V
G
DAR
W
---------------
W
G
G
E
P
V
W
V
G
V
E
N
T
-
G
Q
H
-----------------------
A
---
A
T
W
-
S
-----------
W
---------------------------------
P
G
-----
S
E
-----
A
-----------------------
A
--------
I
-------
K
-------------------------
G
---------
V
-----------------------------------------------
R
---
P
S
-
Q
WR--------
H
Y
-----------------------------
Q
-------
K
-
G
V
R
L
D
T
R
V
D
A
---------
V
R
G
W
L
A
T
---
D
GA---
Q
--
R
N
--
R
------------------
L
V
T
L
Y
F
E
H
V
D
E
A
G
-------
H
D
H
G
----------------------
P
E
---------------------------------------------------------
S
R
Q
--
Y
A
D
A
V
R
A
V
D
A
A
I
G
R
L
L
A
G
M
Q
R
D
G
T
R
A
-
R
------
T
N
I
I
V
V
S
D
H
G
------------
M
A
E
-----
V
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
47.65
13%
-52
- C4 -
1O98
1
GPMI_GEOSE
A:
[314-499]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
T
I
G
E
V
L
S
Q
H
-
G
L
R
-----------------------
Q
---
L
R
I
-
A
E
TEK
Y
P
H
V
T
FF
M
-------------------------------
S
-
G
G
-----
R
E
-----
E
-----------------------
E
FPG-----
E
-------
D
-------------------------
R
---------
I
L
-------
I
-----------------------------
N
-----
S
P
K
V
---
P
T
-
Y
----------
D
L
-----------------------------
K
-------
P
-
E
M
S
A
Y
E
V
T
D
A
---------
L
L
K
E
I
E
A
---
D
--------
K
Y
--
D
------------------
A
I
I
L
N
Y
A
N
P
D
M
---------------
V
G
-------------------------------------------------------------------------
H
S
G
K
L
E
P
--
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
K
G
-----------
G
I
A
I
I
T
A
D
H
G
------------
N
A
D
-----
E
-
V
L
---
T
-----
P
----
D
G
K
-
P
Q
T
------
A
H
--
T
T
N
P
V
P
V
I
V
T
K
-
K
--
G
----
I
----
K
L
----------
R
D
G
G
--------------------------------
I
--------------------------------
L
--
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
---------------------------------------------------------------------------------------------
31
SP3
47.18
5%
-34
- C4 -
1EW2
1
PPB1_HUMAN
A:
[1-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
P
V
E
E
E
N
P
D
F
W
N
R
E
A
A
E
A
L
G
----------
A
A
K
K
L
Q
----
P
A
Q
--
T
A
A
K
-----
N
L
----------------
I
I
F
---------
L
G
D
G
M
G
V
S
T
V
T
------
A
A
R
I
L
K
G
Q
K
K
-----
D
K
L
G
P
E
I
P
L--
A
M
---
D
---
R
F
P
Y
V
A
L
S
K
T
Y
N
V
D
-
K
-
H
-
V
-
P
-
D
S
G
A
T
A
T
A
Y
------------------------------------
L
C
G
V
K
G
N
F
QTIGLSAAA
R
-
F
-
N
------------
Q
----------
C
-
N
---------------
T
-------------------------
T
R
---------------
G
---------------
N
E
V
I
S
V
M
N
R
A
K
K
A
-
G
K
S
-----------------------
V
---
G
V
V
-
T
-----------
T
TRVQH
A
S
P
A
G
T
Y
A
H
T
VNRNWYSDADVP
A
S
A
R
Q
-
E
G
-----
C
Q
-----
D
I
A
T
Q
L
I
S
NMDID
V
I
L
G
G
G
R
K
Y
M
F
R
--------
M
-------
G
-------------------------
T
---------
P
D
-------
P
---------
E
-----
Y
--------
P
----
D
-----
D
Y
S
Q
---
G
G
-
T
----------
R
L
-----------------------------
D
-------
G
-
K
N
L
V
Q
E
W
L
A
K
R
QG
A
R
Y
V
WN
R
T
E
L
M
Q
A
---
S
-----
L
--
D
P
SV
T
------------------
H
L
M
G
L
F
E
P
G
D
M
K
Y
-----
E
I
H
R
D
S
T
L
D
P
S
L
M
E
M
T
E
A
A
L
R
-----
L
L
S
R
-----------
N
P
R
G
F
F
L
F
V
E
G
G
-
R
-------
I
----------------
D
H
G
H
H
E
S
R
A
Y
R
--
A
L
T
E
T
I
M
F
D
D
A
I
E
R
A
G
Q
L
---
T
S
E
-
E
-
D
------
T
L
S
L
V
T
A
D
H
S
------------
H
V
F
S
F
G
G
Y
P
-
L
R
---
G
-----
S
S
I
--
F
G
L
-
A
P
G
----
K
A
R
D
--
R
K
A
Y
T
V
L
L
Y
G
N
G
P
G
Y
V
----
L
K
D
G
A
R
P
D
V
T
E
S
E
S
G
S
P
E
Y
R
Q
QSAVPLD
E
E
T
H
A
G
E
D
V
A
V
F
A
R
G
PQAHLVHGVQ
E
--------------------------------
Q
--
T
F
I
A
H
V
M
A
F
A
A
C
L
E
P
Y
----
T
A
C
D
L
A
P
P
--------------------------------------------------------------------------------
54
HHSearch
46.70
15%
-54
- C4 -
4MY4
-
?
A:
[316-501]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
I
G
E
I
A
Q
N
N
-
N
L
T
-----------------------
Q
---
L
R
I
-
A
-----------
E
TEK
Y
P
H
V
T
YFM--------------------
S
-
G
G
------------------------------------
R
--------
N
-------
E
-------------------------
E
---------
F
K
-------
G
---------
E
-----
R
--------
R
----
R
-----
L
I
D
S
P
KV
A
T
-
Y
----------
D
L
-----------------------------
K
-------
P
-
E
M
S
A
Y
E
V
K
D
A
---------
L
L
E
E
L
N
K
---
G
-----
D
---
L
--
D
------------------
L
I
I
L
N
F
A
N
P
D
---------------
M
V
G
----------
H
----------------------
S
--------
G
---------------------------------
M
L
E
P
--
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
M
D
-----------
G
Y
A
I
I
T
A
D
H
G
------------
N
S
D
--------
Q
---
V
-----
L
T
D
--
D
D
Q
-
P
M
------
T
T
H
--
T
T
N
P
V
P
V
I
V
T
K
E
G
--
V
---------
T
----------
L
R
E
T
G
--------------------------------
R
--------------------------------
L
--
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
---------------------------------------------------------------------------------------------
32
SP3
46.69
5%
-35
- C4 -
1SHN
1
?
A:
[1-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
K
A
Y
W
N
K
D
A
Q
D
A
L
D
--------
K
Q
L
G
I
K
----
L
R
E
--
K
Q
A
K
-----
N
V
----------------
I
F
F
---------
L
G
D
G
M
S
L
S
T
V
T
------
A
A
R
I
Y
K
G
G
L
T
-----
G
K
F
E
R
E
K
I
---
S
W
---
E
---
E
F
D
F
A
A
L
S
K
T
Y
N
T
D
-
K
-
Q
-
V
-
T
-
D
S
A
A
S
A
T
A
Y
------------------------------------
L
T
G
V
-------------
K
-
T
-
N
------------
Q
----------
G
-
V
IGLDANTVRTNCSYQ
L
-------------------------
D
E
---------------
S
---------------
L
F
T
Y
S
I
A
H
W
F
Q
E
A
-
G
R
S
-----------------------
T
---
G
V
V
-
T
-----------
S
TRVTH
A
T
P
A
G
T
Y
A
H
V
ADRDWEN
D
S
D
V
V
----
H
-
D
R
-----
E
D
-----
P
-----------------------
E
--------
I
-------
C
DD
I
A
E
Q
L
V
FREPGKNFK
V
I
M
G
G
GRR
G
---------
F
F
-------
P
---------
E
-----
E
--------
A
----
L
-----
D
I
E
D
---
G
I
-
P
----------
G
E
-----------------------------
R
-------
E
-
D
G
K
H
--
L
I
T
D
---------
W
L
D
D
K
A
S
---
Q
-----
G
--
A
T
--
A
S
Y
V
W
N
R
D
D
L
L
A
VDIRNTD
Y
L
M
G
L
F
S
Y
T
H
L
D
T
-----
V
L
T
R
D
A
E
M
D
P
T
L
P
E
M
T
K
V
A
I
E
-----
M
L
T
K
-----------
D
E
N
G
F
F
L
L
V
E
G
G
-
R
-------
I
----------------
D
H
M
H
H
A
N
Q
I
R
Q
--
S
L
A
E
T
L
D
M
E
E
A
V
S
M
A
L
S
M
T
D
---
P
-
E
-
E
------
T
I
I
L
V
T
A
D
H
G
------------
H
T
L
-----
T
-
I
T
---
G
-----
Y
A
D
--
R
N
T
-
D
I
L
DFAG
I
S
D
L
--
D
D
R
R
Y
T
I
L
D
Y
G
S
G
--
P
G
Y
H
I
T
E
D
G
K
R
Y
E
P
T
E
E
D
L
K
D
I
N
F
R
Y
--------------------------------
A
SAAPKH
S
V
T
H
D
G
T
D
V
G
I
W
V
N
G
PFAHLFTGVYE
E
--
N
Y
I
P
H
A
L
A
Y
A
A
C
V
G
T
G
----
R
T
F
C
D
-----------------------------------------------------------------------------------
36
HHSearch
46.13
16%
28
- C4 -
2QZU
-
?
A:
[25-372]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--
P
T
P
N
------
L
----------------
V
F
I
---------
M
A
D
Q
Y
R
G
D
A
I
G
------
C
--------
I
-----
G
K
E
P
V
K
T
P
---
H
L
D
K
L
A
---
S
E
G
---
I
N
-
F
T
N
A
I
-
S
-
S
-
Y
-
P
-
V
S
S
P
A
R
G
M
L
------------------------------------
M
T
G
M
-------------
Y
P
I
-
G
SKVTGNCNSETA
P
----------
Y
-
G
---------------
V
-------------------------
E
L
---------------
S
---------------
Q
N
A
R
C
W
S
D
V
L
K
D
Q
-
G
Y
N
-----------------------
M
---
G
Y
I
-
G
-----------
K
-------------------------------
W
H
L
D
A
P
Y
K
P
Y
V
-----
D
-----------------------
T
--------
Y
-------
N
-------------------------
N
RGKVAW
N
E
W
C
P
-------
P
ERRHG----
F
-----
D
HWIAYGT-
Y
----
D
-----
Y
H
L
K
---
P
M
-
Y
W
N
TTAPRDS
F
Y
Y
-----------------------------
V
-------
N
-
Q
W
G
P
E
Y
E
A
S
K
---------
A
I
E
Y
I
N
G
---
Q
KDQ--
K
--
Q
P
--
F
------------------
A
L
V
V
S
M
N
P
P
H
T
G
Y
-----
E
--
L
V
P
D
R
Y
K
E
---------
I
-----
Y
K
D
L
D
V
E
A
L
C
KGRPD
I
P
A
--------
K
G
T
-------
E
----------------
M
G
D
Y
F
R
N
N
I
R
N
--
Y
Y
A
C
I
T
G
V
D
E
N
V
G
R
I
I
E
A
L
K
Q
N
N
L
F
D
-
N
------
T
I
V
V
F
T
S
D
H
G
------------
I
C
M
-----
G
-
A
H
---
E
-----
N
A
G
--
K
D
I
-
F
Y
--------
E
--
E
S
M
R
I
P
M
I
L
S
W
P
D
--
Q
----
I
K
P
----------
R
K
S
D
P
L
M
I
--------------------------------
A
--------------------------------
F
--
A
D
L
Y
P
T
L
L
S
M
M
G
F
S
----------------------------------------------------------------------------------------------
59
HHSearch
45.68
15%
-27
- C4 -
3SZY
-
?
A:
[22-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
V
P
-----
A
-----------------
I
A
V
---------
C
L
D
G
C
E
P
A
Y
L
D
------
A
--------
A
-----
I
-
D
A
G
L
M
P
---
A
L
---
K
R
I
K
E
R
G
---
A
V
-
R
L
A
H
S
-
V
-
I
-
P
-
S
-
F
T
N
P
N
N
L
S
I
------------------------------------
A
T
G
S
-------------
P
-
P
-
A
VHGICGN
Y
----
L
----------
Y
-
E
---------------
P
-------------------------
S
T
G
E
E
V
M
MNDPK-----
F
---------------
L
R
A
P
T
I
F
Q
A
F
Y
D
A
-
G
A
R
-----------------------
V
---
A
V
V
-
T
-----------
A
K
D
K
L
R
A
L
L
-----------------------
G
-
K
G
-----
L
R
FDEGR
A
-----------------------
V
--------
C
-------
F
-------------------------
S
---------
S
E
-------
K
---------
S
-----
D
KATRAEHG
I
DN
A
S
A
-----
W
L
G
R
---
P
V
-
P
----------
E
V
-----------------------------
Y
-------
S
-
A
A
L
S
E
F
V
F
A
A
---------
G
V
K
L
L
R
E
---
F
-----
R
--
P
D
--
I
-------------------
M
Y
L
T
T
----
T
D
Y
-----
V
Q
H
K
Y
A
----------------------
P
-------------
G
V
--------------------------------------------
P
E
--
A
N
S
F
Y
E
M
F
D
R
Y
L
A
E
L
D
G
-----
L
----
G
------
A
A
I
V
V
T
A
D
H
G
------------
M
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
45.68
16%
-47
- C4 -
3NKQ
6
ENPP2_MOUSE
A:
[125-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
V
R
P
P
-----
L
-----------------
I
I
F
---------
S
V
D
G
F
R
A
S
Y
M
K
------
K
--------
G
-----
S
K
---
V
M
P
---
N
I
E
K
L
R
---
S
C
G
---
T
H
-
A
P
Y
M
R
-
P
-
V
-
Y
P
T
-
K
T
F
P
N
L
Y
T
L
------------------------------------
A
T
G
L
-------------
Y
-
P
E
S
HGIVGN
S
-----
M
----------
Y
-
D
---------------
P
-------------------------
V
F
---------------
D
A
T
F
H
LRGREKFNHRW
W
G
G
Q
P
L
W
I
T
A
T
K
Q
-
G
V
R
-----------------------
A
G
T
F
F
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
S
-
I
P
-
H
E
R
R
I
L
T
---------
I
L
Q
W
L
S
L
---
P
DN---
E
--
R
P
--
S
------------------
V
Y
A
F
Y
S
E
Q
P
D
F
S
G
-------
H
K
Y
----------------------
G
P
F
-------------
G
--------------------------------------------
P
E
--
M
T
N
P
L
R
E
I
D
K
T
V
G
Q
L
M
D
G
L
K
Q
L
K
L
-
H
R
C
------
V
N
V
I
F
V
G
D
H
G
------------
M
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
User Run . : Multi Template Modeling Result:
(2 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIKPNLRPKL
G
S
S
A
L
I
A
F
L
S
L
Y
S
S
L
V
L
N
Y
A
F
F
A
K
V
V
ELHPFNGTGA
D
I
F
L
Y
T
M
P
V
V
L
F
F
L
S
N
F
V
F
H
V
I
A
L
P
F
V
H
K
V
L
I
P
L
I
L
V
I
S
A
A
V
S
Y
Q
E
I
F
F
N
I
Y
F
N
K
S
M
L
N
N
V
L
Q
T
T
AAES
A
R
LIT
P
G
Y
V
L
W
I
V
C
L
G
V
L
P
A
L
A
Y
I
A
V
K
V
K
Y
R
V
W
Y
K
E
L
L
T
R
L
V
L
A
A
V
S
F
L
C
A
L
G
I
A
M
L
Q
Y
Q
D
Y
A
S
F
F
RNNK
S
V
T
H
L
I
VPSNFIG
A
G
V
S
K
Y
K
DWKRSNI
P
Y
T
Q
L
D
M
A
V
VQNRPAGS
L
R
R
F
V
V
L
V
VGETTR
A
A
NWGLNGYSRQTT
P
L
L
AARGDEIVN
F
P
Q
V
RSCGTSTAHSLP
C
M
F
S
TFDRT
D
Y
D
E
I
K
A
EHQ
D
N
L
L
D
I
V
Q
RAG
V
E
V
T
W
LENDSGCKGVCGKVPNTDVTSLN
L
P
E
Y
CRN
G
E
C
L
D
N
I
L
L
T
K
F
D
E
V
LNKNDK
D
A
V
L
I
L
H
TIGSHG
P
T
Y
Y
E
R
Y
T
E
A
ERKFTPTCD
T
N
E
I
N
K
C
T
R
A
T
L
V
NTYD
N
T
V
L
Y
V
D
Q
F
I
D
K
V
I
R
K
LE
N
R
D
D
L
E
S
V
V
H
Y
V
S
DHGESLGEN
G
M
Y
L
HAAP
Y
A
IAPSGQTH
I
P
M
V
M
W
F
S
K
A
F
R
QHGGI
D
F
Q
C
L
K
Q
K
AAENEYS
H
D
H
Y
F
S
T
V
L
G
L
MDISN
S
Q
T
Y
R
K
E
M
D
I
L
A
A
CRRPR
68
52.99
100%
-6
- C- -
M068
-
A:
[10-768]
M
I
K
P
N
L
R
P
K
L
G
S
S
A
---------
S
L
V
L
N
Y
A
F
F
A
K
V
V
E
L
H
P
F
N
G
T
G
--------------------------------
I
P
L
I
L
V
I
S
A
A
--------
N
I
Y
F
N
K
S
M
L
N
N
V
L
Q
T
T
A
A
E
S
A
R
L
I
T
P
G
Y
V
L
W
I
V
C
L
------------
V
K
Y
R
V
W
Y
K
E
L
L
T
R
L
V
L
A
A
V
S
F
L
C
A
L
G
I
A
M
L
Q
Y
Q
D
Y
A
S
F
F
R
N
N
K
S
V
T
H
L
I
V
P
S
N
F
I
G
A
G
V
S
K
Y
K
D
W
K
R
S
N
I
P
Y
T
Q
L
D
M
A
V
V
Q
N
R
P
A
G
S
L
R
R
F
V
V
L
V
V
G
E
T
T
R
A
A
N
W
G
L
N
G
Y
S
R
Q
T
T
P
L
L
A
A
R
G
D
E
I
V
N
F
P
Q
V
R
S
C
G
T
S
T
A
H
S
L
P
C
M
F
S
T
F
D
R
T
D
Y
D
E
I
K
A
E
H
Q
D
N
L
L
D
I
V
Q
R
A
G
V
E
V
T
W
L
E
N
D
S
G
C
K
G
V
C
G
K
V
P
N
T
D
V
T
S
L
N
L
P
E
Y
C
R
N
G
E
C
L
D
N
I
L
L
T
K
F
D
E
V
L
N
K
N
D
K
D
A
V
L
I
L
H
T
I
G
S
H
G
P
T
Y
Y
E
R
Y
T
E
A
E
R
K
F
T
P
T
C
D
-------
T
R
A
T
L
V
N
T
Y
D
N
T
V
L
Y
V
D
Q
F
I
D
K
V
I
R
K
L
E
N
R
D
D
L
E
S
V
V
H
Y
V
S
D
H
G
E
S
L
G
E
N
G
M
Y
L
H
A
A
P
Y
A
I
A
P
S
G
Q
T
H
I
P
M
V
M
W
F
S
K
A
---------------
A
A
E
N
E
Y
S
H
D
H
Y
F
S
T
V
L
G
L
M
D
I
S
N
S
Q
T
Y
R
K
E
M
D
I
L
A
A
C
R
R
P
R
69
45.54
100%
-7
- C- -
M069
-
A:
[10-792]
M
I
K
P
N
L
R
P
K
L
G
S
S
A
---------
S
L
V
L
N
Y
A
F
F
A
K
V
V
E
L
H
P
F
N
G
T
G
--------------------------------
I
P
L
I
L
V
I
S
A
A
--------
N
I
Y
F
N
K
S
M
L
N
N
V
L
Q
T
T
A
A
E
S
A
R
L
I
T
P
G
Y
V
L
W
I
V
C
L
------------
V
K
Y
R
V
W
Y
K
E
L
L
T
R
L
V
L
A
A
V
S
F
L
C
A
L
G
I
A
M
L
Q
Y
Q
D
Y
A
S
F
F
R
N
N
K
S
V
T
H
L
I
V
P
S
N
F
I
G
A
G
V
S
K
Y
K
D
W
K
R
S
N
I
P
Y
T
Q
L
D
M
A
V
V
Q
N
R
P
A
G
S
L
R
R
F
V
V
L
V
V
G
E
T
T
R
A
A
N
W
G
L
N
G
Y
S
R
Q
T
T
P
L
L
A
A
R
G
D
E
I
V
N
F
P
Q
V
R
S
C
G
T
S
T
A
H
S
L
P
C
M
F
S
T
F
D
R
T
D
Y
D
E
I
K
A
E
H
Q
D
N
L
L
D
I
V
Q
R
A
G
V
E
V
T
W
L
E
N
D
S
G
C
K
G
V
C
G
K
V
P
N
T
D
V
T
S
L
N
L
P
E
Y
C
R
N
G
E
C
L
D
N
I
L
L
T
K
F
D
E
V
L
N
K
N
D
K
D
A
V
L
I
L
H
T
I
G
S
H
G
P
T
Y
Y
E
R
Y
T
E
A
E
R
K
F
T
P
T
C
D
T
N
E
I
N
K
C
T
R
A
T
L
V
N
T
Y
D
N
T
V
L
Y
V
D
Q
F
I
D
K
V
I
R
K
L
E
N
R
D
D
L
E
S
V
V
H
Y
V
S
D
H
G
E
S
L
G
E
N
G
M
Y
L
H
A
A
P
Y
A
I
A
P
S
G
Q
T
H
I
P
M
V
M
W
F
S
K
A
---------------
A
A
E
N
E
Y
S
H
D
H
Y
F
S
T
V
L
G
L
M
D
I
S
N
S
Q
T
Y
R
K
E
M
D
I
L
A
A
C
R
R
P
R