@TOME V2.2
(Nov 2016)
Ref.
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T0843: (2014-07-03 )
AMIPLFKVAVSPTALDRVAEVFASGYLGQGPRVAEFESALAARLGNPRVVSVHSGTSGLCLALRLLDAPEERDEVLSTPLTFEATNWAILADGRRITWVDVDPATLTMDLDDLERKISPATRAIIVVHWTGYPVDLDRLAGILDRAEREHGFRPAVIEDCAHAWGASYRGVPLGSHGNMCVFSFQALHLTCGDGGLLTLPGDELHERAMLRRFYGIDRTADRLRGAYDVAEWGLKWHMTDLNAAIGLANLETVDEQLRLHRENAAFYDKELTGVPGLELLQRSPDREGSFYVYDVKVDDRPAFHRKMEAAGIMAGLVSRRNDEHSCVAHLRTSLPGLDSVYDRMVSLPVGWWLTEQDREHVVATIRSGW
Atome Classification :
(20 SA)
------------------------------------------------------------------.......--..10-----.--........20.......-----.--30.--.......40........50........60.....--------...70.-.......80........90........100.......110.--......120.......130.......140.......150.......160.......170.......180..--..-.-.-.-190........200-........210.......-----220.---...----...----230.......240.......250.......260.......270..------.---.-...---280....-..---..290......-------.------300.......-310.----....-----..-.-320-...--..---.---.---.-330---------------..----------.......340.......350.-......360.......-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------AMI
P
L
F
K
--
V
AV------S--
P
T
A
L
D
R
V
A
E
V
F
ASGYLG-----Q--GP
R
--
V
A
E
F
E
S
A
L
A
A
RLGN
P
R
V
V
S
VHSGTS
G
L
C
L
A
L
R
LL--------DAP
E
E
R
-
D
E
VLSTP
L
T
F
EAT
N
W
A
I
L
ADG
R
R
I
T
W
V
DVDP
A
T
L
T
M
D
L
D
D
L
--
E
R
KISPA
T
R
A
I
I
V
V
HWTGYPV
D
L
D
R
L
A
G
I
L
D
R
A
E
R
EHGFR
P
A
V
I
E
D
C
A
H
A
WGASYRGVPLGSHG
N
M
C
V
F
S
F
--
Q
A
-
L
-
H
-
L
-TC-GDG
G
L
L
TL
P
G
--
D
E
L
H
E
R
A
M
L
R
R
F
YGID
R
T
-----
A
D
R
L---RG
A
----
Y
D
V
----
A
EWG
L
K
W
H
MTDL
N
A
AIGL
A
N
L
E
T
V
D
E
Q
L
R
L
H
RENAAFYDKELTGV------P---
G
-
L
E
L
---
L
Q-RSPD-RE---G
S
F
Y
V
Y
D
V
K
VD-------D------R
P
A
F
H
R
K
M
E
A
-
A
-
G
I
----
M
A
G
L
-----
V
S-R-R-N-D
E
H
--
S
C
---
V
---
A
---
H
-
L
-----------------
R
T----------SLP
G
L
D
S
V
Y
D
R
M
V
SLPV
G
W
W
L-TEQDR
E
H
V
V
A
T
I
RSGW-----
36
HHSearch
90.44
31%
-99
- C1 -
4LC3
10
?
A:
[15-385]
------------------------------------------------------------------
P
F
L
P
F
T
R
--
P
E
I
------
D
--
E
E
T
I
Q
G
V
V
E
V
L
R
S
G
W
I
T
-----
T
--
G
P
Q
--
C
Q
K
F
E
A
A
L
S
E
Y
C
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
I
A
--------
G
V
-
G
P
G
-
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
--
E
Q
A
I
T
P
R
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
----
H
K
L
--
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
--
H
A
-
N
-
K
N
L
-
T
T
-
I
E
G
G
A
L
V
L
N
N
--
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
R
T
-----
G
F
------
D
G
----
M
D
C
----
D
V
L
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
Q
L
P
H
L
E
R
F
T
A
Q
R
R
A
L
A
R
A
Y
F
A
A
F
D
G
G
------
A
---
A
-
A
K
L
GVG
L
P
-
V
A
E
F
-
E
N
---
G
N
W
H
M
F
L
V
T
L
P
LERLTI-
T
------
R
A
E
F
M
A
Q
M
K
E
-
R
-
G
I
----
G
T
G
I
-----
H
Y
-
P
-
A
-
I
-
H
L
F
--
T
L
---
Y
R
A
R
G
---
F
-
K
-----------------
E
G
----------
M
F
P
H
A
E
R
Y
G
A
S
T
V
T
L
P
L
F
T
Q
M
-
T
E
G
D
V
R
R
V
V
D
A
V
N
Q
I
------
39
HHSearch
89.09
31%
-100
- C1 -
3DR4
2
?
A:
[28-390]
---------------------------------------------------------------------
S
V
A
A
--
P
R
L
------
D
--
G
N
E
R
D
Y
V
L
E
C
M
D
T
T
W
I
S
-----
S
V-
G
R
F
--
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
--------
G
I
-
G
P
G
-
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
--
E
A
L
I
T
P
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
----
H
N
L
--
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
--
F
G
-
N
-
A
I
I
-
T
T
-
G
E
G
G
M
I
T
T
N
D
--
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
-------------
R
R
----
Y
W
F
----
P
I
V
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
K
L
A
R
L
------
G
---
N
R
V
T
K
---
P
H
-
V
A
L
T
-
G
R
---
H
V
F
W
M
Y
T
V
R
L
G
EGLST--
T
------
R
D
Q
V
I
K
D
L
D
A
-
L
-
G
I
----
E
S
R
P
-----
V
F
-
H
-
P
-
M
-
H
I
M
--
P
P
---
Y
---
A
---
H
L
A
-----------------
T
D
----------
D
L
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
-
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
-----
14
Fugue
87.79
24%
-100
- C1 -
4K2M
7
NTDA_BACSU
A:
[1-442]
AG
M
Q
K
Q
V
K
ISGK
S
K
E
N
M
S
L
L
K
H
L
K
GDVQGKELVIEDSIVN
E
R
W
K
Q
V
L
KEKIDIEHDLFNYQKNREI
S
K
V
P
F
L
P
--
V
D
R
LIT
N
D
E
V
--
E
D
I
L
N
T
L
T
E
V
L
P
T
G
K
F
T
-----
S
--
G
P
Y
--
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
--------
G
L
N
P
G
--
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
--
E
E
A
I
T
P
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
------
L
K
V
I
E
D
A
C
Q
G
I
G
L
T
D
----
L
G
K
Y
A
D
I
T
T
L
S
F
N-
P
Y
-
K
-
N
-
F
-
G
V
C
G
K
A
G
A
I
A
T
D
N
--
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
-----
V
K
N
-----------
K
K
V
----
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
------
Q
N
K
G
Y
-
I
E
L
---
P
E
-
L
S
E
D
-
H
V
---
W
H
L
F
P
I
K
V
R
T
E
-------
D
------
R
A
D
I
M
T
K
L
N
E
-
D
F
G
V
----
Q
T
D
V
YYPIL
S
H
-
M
-
Q
-
K
-
T
P
L
--
V
Q
---
D
---
K
---
Y
-
A
-----------------
G
L
----------
Q
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
-
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
I
G
4
PsiBlast_PDB
87.66
30%
-99
- C1 -
4LC3
10
?
A:
[16-379]
-------------------------------------------------------------------
F
L
P
F
T
R
--
P
E
I
------
D
--
E
E
T
I
Q
G
V
V
E
V
L
R
S
G
W
I
T
-----
T
--
G
P
Q
--
C
Q
K
F
E
A
A
L
S
E
Y
C
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
I
A
--------
G
V
G
P
G
--
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
--
E
Q
A
I
T
P
R
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
----
A
R
A
H
K
L
R
--
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
--
H
A
N
K
-
N
-
L
-
T
T
-
I
E
G
G
A
L
V
L
N
N
--
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
R
T
-----
G
------
F
D
G
----
M
D
C
----
D
V
L
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
Q
L
P
H
L
E
R
F
T
A
Q
R
R
A
L
A
R
A
Y
F
A
A
F
D
G
G
------
A
---
A
-
A
K
L
---
G
V
-
G
L
P
V
-
A
E
FEN
G
N
W
H
M
F
L
V
T
L
P
LERLTI-
T
------
R
A
E
F
M
A
Q
M
K
E
-
R
-
G
I
----
G
T
G
I
----------------
H
--
Y
P
---
A
---
I
---
H
-
L
-----------------
F
T
L
Y
R
A
R
G
F
K
E
G
M
F
P
H
A
E
R
Y
G
A
S
T
V
T
L
P
L
F
T
Q
M
-
T
E
G
D
V
R
R
V
V
------------
1
PsiBlast_PDB
86.59
30%
-99
- C1 -
1MDX
4
ARNB_SALTY
A:
[10-379]
-------------------------------------------------------------------
F
L
P
F
S
R
--
P
A
M
------
G
--
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-----
T
--
G
P
K
--
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
--------
G
I
-
G
E
G
-
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
--
E
A
A
I
T
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
------
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
-
A
I
F
S
F
--
H
A
-
I
K
N
-
I
-
T
C
-
A
E
G
G
I
V
V
T
D
N
--
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
-----------------
G
RAPQ
A
E
V
----
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
A
M
A
D
L
------
P
---
F
-
Q
P
L
---
S
L
-
P
S
W
E
-
H
I
---
H
A
W
H
L
F
I
I
R
V
D
-------
E
ARCGIT
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
----
G
T
G
L
----------------
H
--
F
R
---
A
---
A
---
H
-
T
-----------------
Q
K
Y
Y
R
E
R
F
PTL-
T
L
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
-
T
E
S
D
F
D
R
V
I
T
A
L
---------
3
PsiBlast_PDB
86.09
30%
-99
- C1 -
1MDO
1
ARNB_SALTY
A:
[10-379]
-------------------------------------------------------------------
F
L
P
F
S
R
--
P
A
M
------
G
--
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-----
T
--
G
P
K
--
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
--------
G
I
-
G
E
G
-
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
--
E
A
A
I
T
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
------
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
-
A
I
F
S
F
--
H
A
-
I
K
N
-
I
-
T
C
-
A
E
G
G
I
V
V
T
D
N
--
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
D
---------------Q---
A
E
V
----
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
A
M
A
D
L
------
P
---
F
-
Q
P
L
---
S
L
-
P
S
W
E
-
H
I
---
H
A
W
H
L
F
I
I
R
V
D
-------
E
ARCGIT
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
----
G
T
G
L
----------------
H
--
F
R
---
A
---
A
---
H
-
T
-----------------
Q
K
Y
Y
R
E
R
F
PTL-
T
L
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
-
T
E
S
D
F
D
R
V
I
T
A
L
---------
43
HHSearch
84.70
31%
-94
- C1 -
2OGA
5
?
A:
[39-392]
------------------------------------------------------------------------
Y
--
E
E
L
------
R
--
A
E
T
D
A
A
I
A
R
V
L
D
S
G
R
Y
L
-----
L
--
G
P
E
--
L
E
G
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
G
L
--------
G
I
-
G
P
G
-
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
--
E
K
A
I
T
P
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
----
H
G
L
--
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
--
Y
P
-
G
K
N
-
L
-
G
C
F
G
D
G
G
A
V
V
T
G
D
--
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
R
Q
---------------
K
----
Y
S
H
----
E
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
L
S
G
L
A
G
L
------
P
---
G
-
I
G
L
---
P
V
-
T
A
P
D
-
T
D
---
P
V
W
H
L
F
T
V
R
T
E
-------
R
------
R
D
E
L
R
S
H
L
D
A
-
R
-
G
I
----
D
T
L
T
-----
H
Y
-
P
V
P
-
V
-
H
L
S
--
P
A
YAG
E
---
A
---
P
-
P
-----------------
E
G
----------
S
L
P
R
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
L
-
E
R
P
Q
A
L
R
V
I
D
A
V
R
E
W
------
34
HHSearch
84.20
32%
-93
* C1 *
1MDO
1
ARNB_SALTY
A:
[10-382]
-------------------------------------------------------------------
F
L
P
F
S
R
--
P
A
M
------
G
--
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-----
T
--
G
P
K
--
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
--------
G
I
-
G
E
G
-
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
--
E
A
A
I
T
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
----
Y
G
I
--
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
-
A
I
F
S
F
--
H
A
-
I
K
N
-
I
-
T
C
-
A
E
G
G
I
V
V
T
D
N
--
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
D
--------------
Q
----
A
E
V
----
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
A
M
A
D
L
------
P
---
F
-
Q
P
L
---
S
L
-
P
S
W
E
-
H
I
---
H
A
W
H
L
F
I
I
R
V
D
EARCGI-
T
------
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
----
G
T
G
L
-----
H
F
-
R
-
A
-
A
-
H
T
Q
--
K
Y
---
Y
---
R
E
R
-
F
-
P
-----------------
T
L
----------
T
L
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
-
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
------
38
HHSearch
83.26
23%
-98
- C1 -
2FNU
4
PSEC_HELPY
A:
[2-368]
------------------------------------------------------------------
K
E
F
A
Y
S
E
--
P
C
L
------
D
--
K
E
D
K
K
A
V
L
E
V
L
N
S
K
Q
L
T
-----
Q
--
G
K
R
--
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
L
L
T
L
Y
R
N
F
S-------
E
F
-
S
A
D
R
N
E
I
I
T
T
P
I
S
F
V
A
T
A
N
M
L
L
E
S
G
Y
T
P
V
F
A
G
I
K
N
D
G
-
N
I
D
E
L
A
L
--
E
K
L
I
N
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
----
H
S
L
--
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
--
H
A
-
I
K
P
-
I
-
T
T
-
A
E
G
G
A
V
V
T
N
D
--
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
-----
D
F
F
------
E
----
G
E
V
----
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
D
R
I
F
K
D
N
------
P
---
Y
-
F
T
P
---
L
H
-
P
L
L
K
-
D
K
---
S
S
N
H
L
Y
P
I
L
M
H
QKFFT--
C
------
K
K
L
I
L
E
S
L
H
K
-
R
-
G
I
----
L
A
Q
V
-----
H
Y
-
K
-
P
-
I
-
Y
Q
Y
--
Q
L
---
Y
---
Q
Q
L
-
F
-
N
-----------------
T
A
----------
P
L
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
L
-
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
------
44
HHSearch
82.92
24%
-102
- C1 -
4K2M
6
NTDA_BACSU
A:
[85-436]
----------------------------------------------------------------------------------------
D
I
L
N
T
L
T
E
V
L
P
T
G
K
F
T
-----
S
--
G
P
Y
--
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
A
L
--------
G
L
-
N
P
G
-
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
--
E
E
A
I
T
P
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
----
Y
K
L
--
K
V
I
E
D
A
C
Q
G
I
G
L
T
----
D
L
G
K
Y
A
D
I
T
T
L
S
F
--
N
P
-
Y
-
K
N
F
G
V
C
-
G
K
A
G
A
I
A
T
D
N
--
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
-----
V
-------
K
N
----
K
K
V
----
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
------
Q
---
N
-
K
G
Y
---
I
E
L
P
E
L
S
-
E
D
---
H
V
W
H
L
F
P
I
K
V
R
TE-----
D
------
R
A
D
I
M
T
K
L
N
E
D
F
-
G
V
----
Q
T
D
V
-----
Y
Y
-
P
-
I
-
L
S
H
M
Q
KT
P
L
---
V
Q
D
-
K
---
Y
-
A
-----------------
G
L
----------
Q
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
-
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
------
31
HHSearch
82.54
25%
-96
- C1 -
3BB8
3
?
A:
[33-433]
-------------------------------------------------------------------
V
V
P
P
S
G
--
K
V
I
------
G
--
T
K
E
L
Q
L
M
V
E
A
S
L
D
G
W
L
T
-----
T
--
G
R
F
--
N
D
A
F
E
K
K
L
G
E
Y
L
G
V
P
Y
V
L
T
T
T
S
G
S
S
A
N
L
L
A
L
T
A
L
T
SPKLGVR
A
L
-
K
P
G
-
D
E
V
I
T
V
A
A
G
F
P
T
T
V
N
P
T
I
Q
N
G
L
I
P
V
F
V
D
V
D
I
P
T
Y
N
V
N
A
S
L
I
--
E
A
A
V
S
D
K
T
K
A
I
M
I
A
H
T
L
G
N
L
F
D
L
A
E
V
R
R
V
A
D
K
----
Y
N
L
--
W
L
I
E
D
C
C
D
A
L
G
S
T
Y
D
G
K
M
A
G
T
F
G
D
I
G
T
V
S
F
--
Y
P
A
K
-
H
-
I
-
T
M
-
G
E
G
G
A
V
F
T
Q
S
--
A
E
L
K
S
I
I
E
S
F
R
D
W
G
R
D
C
-QLGSL
P
F
G
Y
---
D
H
K
----
Y
T
Y
----
S
H
L
G
Y
N
L
K
I
T
D
M
Q
A
A
C
G
L
A
Q
L
E
R
I
E
E
F
V
E
K
R
K
A
N
F
K
Y
L
K
D
A
L
Q
S
C
------
A
---
D
F
I
E
L
---
P
E
-
A
T
E
N
-
S
D
---
P
S
W
F
G
F
P
I
T
L
K
EDSGV--
S
------
R
I
D
L
V
K
F
L
D
E
-
A
-
K
V
----
G
T
R
L
-----
L
F
-
A
G
N
-
L
-
T
R
Q
--
P
Y
---
F
---
H
---
D
-
V
K
Y
R
V
-------------
V
G
----------
E
L
T
N
T
D
R
I
M
N
Q
T
F
W
I
G
I
Y
P
G
L
-
T
H
D
H
L
D
Y
V
V
S
K
F
E
E
F
F
-----
2
PsiBlast_PDB
81.89
30%
-96
- C1 -
1MDZ
1
ARNB_SALTY
A:
[10-379]
-------------------------------------------------------------------
F
L
P
F
S
R
--
P
A
M
------
G
--
A
E
E
L
A
A
V
K
T
V
L
D
S
G
W
I
T
-----
T
--
G
P
K
--
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
A
L
--------
G
I
-
G
E
G
-
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
--
E
A
A
I
T
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
------
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
-
A
I
F
S
F
--
H
A
-
I
K
N
-
I
-
T
C
-
A
E
G
G
I
V
V
T
D
N
--
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
D
---------------Q---
A
E
V
----
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
H
Q
A
M
A
D
L
------
P
---
F
-
Q
P
L
---
S
L
-
P
S
W
E
-
H
I
---
H
A
W
H
L
F
I
I
R
V
D
-------
E
ARCGIT
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
----
G
T
G
L
----------------
H
--
F
R
---
A
---
A
---
H
-
T
-----------------
Q
K
Y
Y
R
E
R
F
P
TL-
T
L
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
-
T
E
S
D
F
D
R
V
I
T
A
L
---------
37
HHSearch
81.06
29%
-93
- C1 -
3NYT
1
WBPE_PSEAE
A:
[11-359]
------------------------------------------------------------------------
Q
--
A
R
I
------
K
--
D
K
I
D
A
G
I
Q
R
V
L
R
H
G
Q
Y
I
-----
L
--
G
P
E
--
V
T
E
L
E
D
R
L
A
D
F
V
G
A
K
Y
C
I
S
C
A
N
G
T
D
A
L
Q
I
V
Q
M
A
L
--------
G
V
-
G
P
G
-
D
E
V
I
T
P
G
F
T
Y
V
A
T
A
E
T
V
A
L
L
G
A
K
P
V
Y
V
D
I
D
P
R
T
Y
N
L
D
P
Q
L
L
--
E
A
A
I
T
P
R
T
K
A
I
I
P
V
S
L
Y
G
Q
C
A
D
F
D
A
I
N
A
I
A
S
K
----
Y
G
I
--
P
V
I
E
D
A
A
Q
S
F
G
A
S
Y
K
G
K
R
S
C
N
L
S
T
V
A
C
T
S
F
--
F
P
-
S
-
A
P
L
-
G
C
Y
G
D
G
G
A
I
F
T
N
D
--
D
E
L
A
T
A
I
R
Q
I
A
R
H
G
Q
D
---------------
R
R
----
Y
H
H
----
I
R
V
G
V
N
S
R
L
D
T
L
Q
A
A
I
L
L
P
K
L
E
I
F
E
E
E
I
A
L
R
Q
K
V
A
A
E
Y
D
L
S
L
K
Q
V
------
G
-----
I
G
T
---
P
F
-
I
E
V
N
-
N
I
---
S
V
Y
A
Q
Y
T
V
R
M
D
-------
N
------
R
E
S
V
Q
A
S
L
K
A
-
A
-
G
V
----
P
T
A
V
-----
H
Y
-
P
I
P
-
L
-
N
K
Q
--
P
A
---
V
---
A
---
D
-
E
-----------------
K
A
----------
K
L
P
V
G
D
K
A
A
T
Q
V
M
S
L
P
M
H
P
Y
L
-
D
T
A
S
I
K
I
I
C
A
A
L
T
N
-------
5
PsiBlast_PDB
75.40
31%
-98
- C1 -
3DR4
2
?
A:
[40-386]
-------------------------------------------------------------------------------------------
D
Y
V
L
E
C
M
D
T
T
W
I
S
-----
S
V-
G
R
F
--
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
A
M
---------
G
I
G
P
G
-
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
--
E
A
L
I
T
P
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
---
I
L
E
V
A
R
R
H
N
L
L
---
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
FG
N
A
-
I
---
I
-
T
T
-
G
E
G
G
M
I
T
T
N
D
--
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
-----
R
--------
R
----
Y
W
F
----
P
I
V
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
E
Q
K
L
A
R
L
GNRVT
K
P
---
H
-
V
A
L
---
T
G
-
R
H
---------
V
F
W
M
Y
T
V
R
L
G
-------
E
GLSTT-
R
D
Q
V
I
K
D
L
D
A
-
L
-
G
I
----
E
S
R
P
-----
V
F
-
H
-
P
-
M
-
H
I
M
--
P
P
---
Y
---
A
---
H
-
L
-----------------
A
T
D---------
D
L
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
-
T
E
A
D
I
D
R
V
I
A
A
L
---------
6
PsiBlast_PDB
75.20
31%
-95
- C1 -
2OGA
5
?
A:
[50-390]
---------------------------------------------------------------------------------------------
I
A
R
V
L
D
S
G
R
Y
L
-----
L
--
G
P
E
--
L
E
G
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
G
L
--------
G
I
-
G
P
G
-
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
--
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
E
K
A
I
T
P
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
----
H
G
L
H
--
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y-
P
G
-
K
-
N
-
L
-
G
C
F
G
D
G
G
A
V
V
T
G
D
--
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
---------------
R
Q
K
----
Y
S
H
----
E
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
L
S
G
L
A
G
L
------
P
---
G
-
I
G
L
---
P
V
-
T
A
P
D
-
T
D
---
P
V
W
H
L
F
T
V
R
T
E
-------
R
------
R
D
E
L
R
S
H
L
D
A
-
R
-
G
I
D
T
L
T
H
Y
P
V
-----
P
V
-
H
-
L
-
S
-
P
A
Y
--
A
G
---
E
---
A
---
P
-
P
-----------------
E
G
----------
S
L
P
R
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
L
-
E
R
P
Q
A
L
R
V
I
D
A
V
R
--------
32
HHSearch
73.54
25%
-94
- C1 -
1B9H
1
RIFK_AMYMS
A:
[11-385]
-----------------------------------------------------------------------
A
W
--
P
Q
Y
------
D
--
D
A
E
R
N
G
L
V
R
A
L
E
Q
G
Q
W
W
-----
R
MG
G
D
E
--
V
N
S
F
E
R
E
F
A
A
H
H
G
A
A
H
A
L
A
V
T
N
G
T
H
A
L
E
L
A
L
Q
V
M
--------
G
V
-
G
P
G
-
T
E
V
I
V
P
A
F
T
F
I
S
S
S
Q
A
A
Q
R
L
G
A
V
T
V
P
V
D
V
D
A
A
T
Y
N
L
D
P
E
A
V
--
A
A
A
V
T
P
R
T
K
V
I
M
P
V
H
M
A
G
L
M
A
D
M
D
A
L
A
K
I
S
A
D
----
T
G
V
--
P
L
L
Q
D
A
A
H
A
H
G
A
R
W
Q
G
K
R
V
G
E
L
D
S
I
A
T
F
S
F
--
Q
N
-
G
K
L
-
M
-
T
A
-
G
E
G
G
A
V
V
F
P
D
GE
T
E
K
Y
E
T
A
F
L
R
H
S
C
G
R
P
R
D
-----
D
-------
R
R
----
Y
F
H
----
K
I
A
G
S
N
M
R
L
N
E
F
S
A
S
V
L
R
A
Q
L
A
R
L
D
E
Q
I
A
V
R
D
E
R
W
T
L
L
S
R
L
L
G
A
I
------
D
---
G
-
V
V
P
---
Q
G
-
G
D
V
R
A
D
R
---
N
S
H
Y
M
A
M
F
R
I
P
GLT
E
E
--
R
------
R
N
A
L
V
D
R
L
V
E
-
A
-
G
L
----
P
A
F
A
-----
A
F
-
R
-
A
-
I
-
Y
R
T
--
D
A
---
F
---
W
ELG
A
-
P
DES
V
D
A
I
----------
A
R
----------
R
C
P
N
T
D
A
I
S
S
D
C
V
W
L
H
H
R
V
L
L
A
G
E
P
E
L
H
A
T
A
E
I
I
A
D
A
V
-----
30
HHSearch
73.49
24%
-92
- C1 -
2C81
1
GLDSA_BACCI
A:
[10-411]
-----------------------------------------------------------------------
E
W
--
P
Q
H
------
S
--
D
R
T
R
R
K
I
E
E
V
F
Q
S
N
R
W
A
ISGYW
T
--
G
E
E
S
M
E
R
K
F
A
K
A
F
A
D
F
N
G
V
P
Y
C
V
P
T
T
S
G
S
T
A
L
M
L
A
L
E
A
L
--------
G
I
-
G
E
G
-
D
E
V
I
V
P
S
L
T
W
I
A
T
A
T
A
V
L
N
V
N
A
L
P
V
F
V
D
V
E
A
D
T
Y
C
I
D
P
Q
L
I
--
K
S
A
I
T
D
K
T
K
A
I
I
P
V
H
L
F
G
S
M
A
N
M
D
E
I
N
E
I
A
Q
E
----
H
N
L
--
F
V
I
E
D
C
A
Q
S
H
G
S
V
W
N
N
Q
R
A
G
T
I
G
D
I
G
A
F
S
C
--
Q
Q
-
G
K
V
-
L
-
T
A
-
G
E
G
G
I
I
V
T
K
N
--
P
R
L
F
E
L
I
Q
Q
L
R
A
D
S
R
V
Y
C
-----
D
D
S
S
ELM
H
G
D
----
M
Q
L
V
K
K
G
D
I
Q
G
S
N
Y
C
L
S
E
F
Q
S
A
I
L
L
D
Q
L
Q
E
L
D
D
K
N
A
I
R
E
K
N
A
M
F
L
N
D
A
L
S
K
I
------
D
---
G
-
I
K
V
---
M
K
-
R
P
P
Q
V
S
R
---
Q
T
Y
Y
G
Y
V
F
R
F
D
PVKFGGL
N
------
A
D
Q
F
C
E
I
L
R
E
-
K
L
N
M
GTF-
Y
L
H
P
-----
P
Y
-
L
-
P
-
V
-
H
K
N
--
P
L
---
F
---
C
---
P
-
W
TKNRYLKSVRKT
E
A
Y
W
R
G
L
----------
H
Y
P
V
S
E
R
A
S
G
Q
S
I
V
I
H
H
A
I
L
L
A
E
P
S
H
L
S
L
L
V
D
A
V
A
E
L
A
-----
33
HHSearch
73.48
22%
-94
- C1 -
3FRK
2
?
A:
[5-365]
-------------------------------------------------------------------
F
A
S
F
K
P
M
H
D
E
I
------
E
--
Y
E
I
K
F
K
F
E
E
I
Y
K
R
N
W
F
I
-----
L
--
G
D
E
--
D
K
K
F
E
Q
E
F
A
D
Y
C
N
V
N
Y
C
I
G
C
G
N
G
L
D
A
L
H
L
I
L
K
G
Y
--------
D
I
-
G
F
G
-
D
E
V
I
V
P
S
N
T
F
I
A
T
A
L
A
V
S
Y
T
G
A
K
P
I
F
V
E
P
D
I
R
T
Y
N
I
D
P
S
L
I
--
E
S
A
I
T
E
K
T
K
A
I
I
A
V
H
L
Y
G
Q
P
A
D
M
D
E
I
K
R
I
A
K
K
----
Y
N
L
--
K
L
I
E
D
A
A
Q
A
H
G
S
L
Y
K
G
M
K
V
G
S
L
G
D
A
A
G
F
S
F
--
Y
P
-
A
-
K
N
L
-
G
S
L
G
D
G
G
A
V
V
T
N
D
--
K
D
L
A
E
K
I
K
A
L
S
N
Y
G
S
E
K
---------------
K
----
Y
H
H
----
I
Y
K
G
F
N
S
R
L
D
E
L
Q
A
G
F
L
R
V
K
L
K
Y
L
D
K
W
N
E
E
R
R
K
I
A
Q
K
Y
I
A
G
I
N
N
P
----------
N
-
V
I
I
---
P
V
-
E
A
D
Y
-
A
K
---
H
V
W
Y
T
F
V
I
R
S
E
-------
K
------
R
D
E
L
Q
K
Y
L
N
N
-
N
-
G
I
----
G
T
L
I
-----
H
Y
-
P
I
P
-
I
-
H
L
Q
--
Q
A
---
Y
KDL
G
---
F
-
K
-----------------
T
G
----------
N
F
P
I
A
E
K
I
A
N
E
I
L
S
I
P
I
W
Y
G
M
-
K
N
E
E
I
E
Y
V
I
D
K
I
N
A
W
K
-----
41
HHSearch
73.03
23%
-93
- C1 -
3UWC
3
?
A:
[14-367]
-----------------------------------------------------------------------
Q
F
--
A
D
I
------
E
---
P
Y
L
N
D
L
R
E
F
I
K
T
A
D
F
T
-----
L
--
G
A
E
--
L
E
K
F
E
K
R
F
A
A
L
H
N
A
P
H
A
I
G
V
G
T
G
T
D
A
L
A
M
S
F
K
M
L
--------
N
I
-
G
A
G
-
D
E
V
I
T
C
A
N
T
F
I
A
S
V
G
A
I
V
Q
A
G
A
T
P
V
L
V
D
S
E
N
-
G
Y
V
I
D
P
E
K
I
--
E
A
A
I
T
D
K
T
K
A
I
M
P
V
H
Y
T
G
N
I
A
D
M
P
A
L
A
K
I
A
K
K
----
H
N
L
--
H
I
V
E
D
A
C
Q
T
I
L
G
R
I
N
D
K
F
V
G
S
W
G
Q
F
A
C
F
S
L
--
H
P
-
L
-
K
N
L
-
N
V
W
S
D
A
G
V
I
I
T
H
S
--
D
E
Y
A
E
K
L
R
L
Y
R
N
H
G
L
I
N
---------------
R
----
D
V
C
----
V
E
Y
G
I
N
C
R
M
D
T
I
Q
A
V
I
A
N
R
L
M
N
Q
L
E
T
I
T
E
K
R
R
G
I
A
H
L
Y
D
Q
S
F
V
D
L
------
S
E--
F
-
I
D
V
---
P
V
-
R
R
E
G
-
V
Y
---
H
V
F
H
I
Y
V
L
R
V
K
-------
Y
------
R
D
Q
L
F
Q
Y
L
K
D
-
N
-
G
I
----
E
V
K
I
-----
H
Y
P
I
-
A
-
M
-
H
L
Q
--
P
A
---
A
KSL
G
---
Y
-
Q
-----------------
Q
G
----------
D
F
P
M
A
E
K
H
G
E
A
V
I
T
L
P
A
H
P
Y
L
-
T
E
E
E
I
N
Y
I
I
K
K
V
R
E
F
------
40
HHSearch
71.39
27%
-88
- C1 -
2PO3
2
?
A:
[20-382]
-------------------------------------------------------------------
P
L
L
V
G
R
--
P
N
R
------
I
D
R
A
R
L
Y
E
R
L
D
R
A
L
D
S
Q
W
L
S
-----
N
G-
G
P
L
--
V
R
E
F
E
E
R
V
A
G
L
A
G
V
R
H
A
V
A
T
C
N
A
T
A
G
L
Q
L
L
A
H
A
A
--------
G
L
--
T
G
--
E
V
I
M
P
S
M
T
F
A
A
T
P
H
A
L
R
W
I
G
L
T
P
V
F
A
D
I
D
P
D
T
G
N
L
D
P
D
Q
V
--
A
A
A
V
T
P
R
T
S
A
V
V
G
V
H
L
W
G
R
P
C
A
A
D
Q
L
R
K
V
A
D
E
----
H
G
L
--
R
L
Y
F
D
A
A
H
A
L
G
C
A
V
D
G
R
P
A
G
S
L
G
D
A
E
V
F
S
F
--
H
A
-
T
-
K
A
V
-
N
A
-
F
E
G
G
A
V
V
T
D
D
--
A
D
L
A
A
R
I
R
A
L
H
N
F
G
F
D
L
---------------
P
----
G
G
S
----
P
A
G
G
T
N
A
K
M
S
E
A
A
A
A
M
G
L
T
S
L
D
A
F
P
E
V
I
D
R
N
R
R
N
H
A
A
Y
R
E
H
L
A
D
L
------
P
---
G
-
V
L
V
---
A
D
-
H
D
R
H
-
G
L
---
N
N
H
Q
Y
V
I
V
E
I
D
EATTGI-
H
------
R
D
L
V
M
E
V
L
K
A
-
E
-
G
V
----
H
T
R
A
-----
Y
F
-
S
-
P
G
C
-
H
E
L
--
E
P
---
Y
---
R
G--
Q
-
P
-----------------
H
A
----------
P
L
P
H
T
E
R
L
A
A
R
V
L
S
L
P
T
G
T
A
I
-
G
D
D
D
I
R
R
V
A
D
L
L
R
L
C
------
User Run . : Multi Template Modeling Result:
(1 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
AMI
P
L
F
K
V
AVS
P
T
A
L
D
R
V
A
E
V
F
ASGYLGQGP
R
V
A
E
F
E
S
A
L
A
A
RLGN
P
R
V
V
S
VHSGTS
G
L
C
L
A
L
R
LLDAP
E
E
R
D
E
VLSTP
L
T
F
EAT
N
W
A
I
L
ADG
R
R
I
T
W
V
DVDP
A
T
L
T
M
D
L
D
D
L
E
R
KISPA
T
R
A
I
I
V
V
HWTGYPV
D
L
D
R
L
A
G
I
L
D
R
A
E
R
EHGFR
P
A
V
I
E
D
C
A
H
A
WGASYRGVPLGSHG
N
M
C
V
F
S
F
Q
A
L
H
L
TCGDG
G
L
L
TL
P
G
D
E
L
H
E
R
A
M
L
R
R
F
YGID
R
T
A
D
R
LRG
A
Y
D
V
A
EWG
L
K
W
H
MTDL
N
A
AIGL
A
N
L
E
T
V
D
E
Q
L
R
L
H
RENAAFYDKELTGVP
G
L
E
L
L
QRSPDREG
S
F
Y
V
Y
D
V
K
VDDR
P
A
F
H
R
K
M
E
A
A
G
I
M
A
G
L
V
SRRND
E
H
S
C
V
A
H
L
R
TSLP
G
L
D
S
V
Y
D
R
M
V
SLPV
G
W
W
LTEQDR
E
H
V
V
A
T
I
RSGW
72
36.59
100%
-15
- C- -
M072
-
A:
[3-468]
A
M
I
P
L
F
K
V
A
V
S
P
T
A
L
D
R
V
A
E
V
F
A
S
G
Y
L
G
Q
G
P
R
V
A
E
F
E
S
A
L
A
A
R
L
G
N
P
R
V
V
S
V
H
S
G
T
S
G
L
C
L
A
L
R
L
L
D
A
P
E
E
R
D
E
V
L
S
T
P
L
T
F
E
A
T
N
W
A
I
L
A
D
G
R
R
I
T
W
V
D
V
D
P
A
T
L
T
M
D
L
D
D
L
E
R
K
I
S
P
A
T
R
A
I
I
V
V
H
W
T
G
Y
P
V
D
L
D
R
L
A
G
I
L
D
R
A
E
R
E
H
G
F
R
P
A
V
I
E
D
C
A
H
A
W
G
A
S
Y
R
G
V
P
L
G
S
H
G
N
M
C
V
F
S
F
Q
A
L
H
L
T
C
G
D
G
G
L
L
T
L
P
G
D
E
L
H
E
R
A
M
L
R
R
F
Y
G
I
D
R
T
A
D
R
L
R
G
A
Y
D
V
A
E
W
G
L
K
W
H
M
T
D
L
N
A
A
I
G
L
A
N
L
E
T
V
D
E
Q
L
R
L
H
R
E
N
A
A
F
Y
D
K
E
L
T
G
V
P
G
L
E
L
L
Q
R
S
P
D
R
E
G
S
F
Y
V
Y
D
V
K
V
D
D
R
P
A
F
H
R
K
M
E
A
A
G
I
M
A
G
L
V
S
R
R
N
D
E
H
S
C
V
A
H
L
R
T
S
L
P
G
L
D
S
V
Y
D
R
M
V
S
L
P
V
G
W
W
L
T
E
Q
D
R
E
H
V
V
A
T
I
R
S
G
W